Materiały źródłowe

• #1 Arteriosclerosis / atherosclerosis // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/arteriosclerosis/atherosclerosis

  Mild atherosclerosis usually doesn’t cause symptoms. […] Atherosclerosis symptoms usually don’t happen until an artery is so narrowed or clogged that it can’t send enough blood to organs and tissues. Sometimes a blood clot completely blocks blood flow. The clot may break apart. If this happens, it may cause a heart attack or stroke. […] Symptoms of moderate to severe atherosclerosis depend on which arteries are affected. For example, if you have atherosclerosis: In your heart arteries, you may have chest pain or pressure, called angina. […] In the arteries leading to your brain, you may have sudden numbness or weakness in your arms or legs, trouble speaking, slurred speech, sudden or temporary loss of vision in one eye, or drooping muscles in your face. These are symptoms of a transient ischemic attack (TIA). Untreated, a TIA can lead to a stroke.

• #1

  https://www.advocatehealth.com/health-services/advocate-heart-institute/conditions/vascular-disease/atherosclerosis

  Atherosclerosis symptoms can begin as early as childhood and usually progress more rapidly between ages 40 and 50. […] By age 60 about 75% of people have some degree of atherosclerosis. […] As atherosclerosis progresses, the signs depend on which arteries in your body are clogged. […] If atherosclerosis is in the arteries leading to your brain, you may feel symptoms of atherosclerosis that are similar to stroke, such as a sudden numbness or weakness in your arms or legs; difficulty speaking or slurred speech; sudden changes in eyesight, dizziness, sudden and severe headache; or drooping muscles in your face. […] If atherosclerosis is in your coronary (heart) arteries, you may experience atherosclerosis symptoms such as chest pain, shortness of breath or heart attack. […] If atherosclerosis is in your intestinal arteries, you may have severe abdominal pain and weight loss. […] If atherosclerosis is in your leg arteries, atherosclerosis symptoms may include pain when walking.

• #1 Atherosclerosis – Wikipedia

  https://en.wikipedia.org/wiki/Atherosclerosis

  Atherosclerosis is typically asymptomatic for decades because the arteries enlarge at all plaque locations, thus there is no effect on blood flow. […] At the onset there are usually no symptoms, but if they develop, symptoms generally begin around middle age. […] Signs and symptoms only happen after severe narrowing or closure impedes blood flow to different organs enough to induce symptoms. […] Marked narrowing in the coronary arteries, which are responsible for bringing oxygenated blood to the heart, can produce symptoms such as chest pain of angina and shortness of breath, sweating, nausea, dizziness or lightheadedness, breathlessness or palpitations. […] Marked narrowing of the carotid arteries can present with symptoms such as a feeling of weakness; being unable to think straight; difficulty speaking; dizziness; difficulty in walking or standing up straight; blurred vision; numbness of the face, arms and legs; severe headache; and loss of consciousness.

• #1 Atherosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16753-atherosclerosis-arterial-disease

  Atherosclerosis symptoms often dont start until an artery is very narrow or blocked. Many people dont know they have plaque buildup until they have a medical emergency like a heart attack or stroke. […] You may notice symptoms of atherosclerosis if your artery is more than 70% blocked. You can have symptoms in different parts of your body, depending on the location of the blockage. […] Coronary artery disease (CAD, which can lead to a heart attack) happens in the arteries that supply blood to your heart. […] You may experience: Shortness of breath (dyspnea) during light physical activity. Chest pain or discomfort (angina). Pain in your back, shoulders, neck, arms or belly. Feeling dizzy or lightheaded. Heart palpitations. Fatigue. Nausea or vomiting that may feel like indigestion. […] Mesenteric ischemia happens when you dont have enough blood flow in parts of your digestive system. You may experience: Pain or cramping in your belly (abdomen) after eating. Bloating, nausea and vomiting. Diarrhea. Unintentional weight loss due to food fear (fear of pain after eating).

• #1 Atherosclerosis – Symptoms | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis/symptoms

  Early stages of atherosclerosis often do not cause symptoms. […] Symptoms may first appear when you are under physical or emotional stress times when the body needs more oxygen. […] Some people may not notice symptoms until plaque buildup causes serious problems. […] Atherosclerosis reduces the supply of oxygen-rich blood to the tissues and organs of the body. Symptoms can lower your quality of life or lead to death. […] Symptoms depend on which arteries are affected and how much blood flow is blocked. You may not notice symptoms until plaque buildup causes severe problems. […] Some conditions caused by atherosclerosis and their symptoms include the following: […] Coronary heart disease includes symptoms of chest pain (angina), heart palpitations (feeling that your heart is racing), shortness of breath, cold sweats, dizziness, extreme tiredness and weakness, and nausea.

• #1 Stages of Atherosclerosis | CMS Fitness Courses

  https://www.cmsfitnesscourses.co.uk/blog/stages-of-atherosclerosis/

  Atherosclerosis develops in several stages: Endothelial Injury, Fatty Streak Formation, Plaque Formation, Fibrous Cap Formation, and Plaque Rupture and Blood Clot Formation. […] The fibrous cap is a layer of connective tissue (collagen) that forms over the fatty plaque, helping to stabilise it and prevent it from rupturing.

• #1 What is Atherosclerosis? | American Heart Association

  https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/atherosclerosis

  Plaque buildup, or fatty deposits, in your arteries is called atherosclerosis. These deposits are made up of cholesterol, fatty substances, cellular waste products, calcium and fibrin, a clotting material in the blood. Atherosclerosis is a type of arteriosclerosis. Arteriosclerosis means hardening of the arteries. […] As plaque builds up, the wall of the blood vessel thickens. This narrows the channel within the artery – reducing blood flow. That lessens the amount of oxygen and other nutrients reaching the body. […] Atherosclerosis is a slow, lifelong progression of changes in the blood vessels that may start in childhood and get worse faster as you age. […] Many scientists believe plaque begins when an artery’s inner lining becomes damaged. Four possible causes of such damage are: Elevated levels of cholesterol and triglycerides in the blood, High blood pressure, Tobacco smoking, such as cigarettes, Diabetes. […] Smoking plays a big role in the progression of atherosclerosis in the aorta (the body’s main artery), coronary arteries and arteries in the legs. Smoking makes fatty deposits more likely to form, and it speeds up the growth of plaque.

• #1 Atherosclerosis Symptoms and Causes

  https://www.verywellhealth.com/what-is-atherosclerosis-1745908

  Atherosclerosis is a chronic, progressive disease in which fatty deposits, called plaque, build up in the walls of arteries. […] Atherosclerosis begins as a gradual, progressive disease that commonly will have develops over decades before it ever begins to produce symptoms. […] First, plaques can protrude into the artery, eventually causing a partial or complete obstruction of blood flow. Stable angina is an example of a medical condition produced by a gradually worsening plaque. […] Second, plaques can cause arterial thrombosis. Arterial thrombosis occurs when a plaque suddenly ruptures, causing a thrombus (blood clot) to form. The thrombosis can lead to a sudden occlusion of the artery. One medical problem produced by plaque rupture is acute coronary syndrome (ACS). […] Third, plaques can weaken the wall of the artery causing a ballooning out of the artery to form what is called an aneurysm. The rupturing of an aneurysm often produces severe internal bleeding. A ruptured aortic aneurysm is an example of such an event.

• #1 Atherosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16753-atherosclerosis-arterial-disease

  You may experience: Dizziness. Drooping on one side of your face. Loss of feeling, loss of muscle strength or weakness on one side of your body. Severe headache. Slurred speech or difficulty forming words. Vision loss in one eye. You may notice a dark shade coming down over your field of sight. […] Early diagnosis and treatment of atherosclerosis can help you avoid or delay complications.

• #1 Arteriosclerosis / atherosclerosis // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/arteriosclerosis/atherosclerosis

  In the arteries in your arms and legs, you may have leg pain when walking, called claudication. This is a symptom of peripheral artery disease (PAD). You also might have lower blood pressure in the affected arm or leg. […] In the arteries leading to your kidneys, you may get high blood pressure or kidney failure.

• #1 Atherosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16753-atherosclerosis-arterial-disease

  Peripheral artery disease (PAD) refers to poor blood flow in the arteries in your limbs. […] You may experience: Muscle pain (intermittent claudication). Burning or aching pain in your feet and toes when you rest, especially when lying flat. Changes in skin color (like redness). Cool skin on your feet. Frequent skin and soft tissue infections, often in your legs or feet. Sores on your feet or toes that dont heal. […] With renal artery stenosis (narrowing of the arteries that take blood to your kidneys), you may experience: Markedly elevated blood pressure that doesnt respond to multiple medications. Changes in how often you pee. Swelling (edema). Feeling drowsy or tired. Skin that feels dry, itchy or numb. Headaches. Unexplained weight loss. Nausea, vomiting or loss of appetite. […] With carotid artery disease, the first symptoms are usually a transient ischemic attack (TIA) or stroke.

• #1 Recognizing the Signs of Artery Disease in Your Arms: Vascular Institute of New York: Board Certified Vascular and Endovascular Surgeons

  https://www.vascularnyc.com/blog/recognizing-the-signs-of-artery-disease-in-your-arms

  Atherosclerosis can affect any artery in your body, including the main artery in your neck that supplies your brain with oxygen-rich blood (carotid artery disease) as well as the large arteries of your heart (coronary artery disease). […] PAD is the form of atherosclerosis that affects your peripheral arteries, or the arteries in your arms, pelvis, or legs. More than 10 million people in the United States live with PAD, and most experience its symptoms in their lower extremities (leg artery disease). […] In its earliest stages, PAD-related arm artery disease is a relatively silent, or hidden, disorder that doesnt cause noticeable symptoms. One of the first symptoms you may experience as it gradually progresses is intermittent claudication (IC). […] As arm artery disease continues to progress, your fingers may begin to feel uncomfortable or even painful when theyre resting. You may also experience noticeable skin changes on your fingers or hands your fingers may turn pale white or even blue, and your entire hand may become more sensitive to cold temperatures.

• #1 Arthrosclerotic renovascular disease: treatment and symptoms

  https://www.kidneyresearchuk.org/conditions-symptoms/atherosclerotic-renovascular-disease/

  The most common symptom is that of high blood pressure (hypertension). Some people with ARVD may have already developed mild to moderate chronic kidney disease, which often has no noticeable symptoms. Others may have some of the symptoms of more advanced kidney disease. […] People can also have: […] High blood pressure that does not respond to common drug treatments or needs multiple blood pressure medications to bring it under control […] Sudden attacks of fluid on the lungs, called ‘flash pulmonary oedema’ […] ARVD may also be suspected if you experience a drop of more than 20 per cent in your kidney function with certain blood pressure medication. […] Recent studies have also shown that medication without angioplasty is preferable for most people with clinically stable ARVD.

• #1 Atherosclerosis Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/atherosclerosis.html

  Atherosclerosis usually doesn’t cause any symptoms until blood supply to an organ is reduced. When this happens, symptoms vary, depending on the specific organ involved: […] Symptoms include the chest pain of angina and shortness of breath, sweating, nausea, dizziness or light-headedness, breathlessness or palpitations. […] When atherosclerosis narrows brain arteries, it can cause dizziness or confusion; weakness or paralysis on one side of the body; sudden, severe numbness in any part of the body; visual disturbance, including sudden loss of vision; difficulty walking, including staggering or veering; coordination problems in the arms and hands; and slurred speech or inability to speak. […] When atherosclerosis narrows the arteries to the intestines, there may be dull or cramping pain in the middle of the abdomen, usually beginning 15 to 30 minutes after a meal. Sudden complete blockage of an intestinal artery often causes severe abdominal pain, sometimes with vomiting, bloody stool and abdominal swelling.

• #1 Arteriosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24870-arteriosclerosis

  Arteriosclerosis usually doesn’t cause symptoms until it leads to complications. Symptoms vary widely depending on the problem and can include: […] Arteriosclerosis is a gradual process that occurs over many years. It can be dangerous because it develops silently. You may have no symptoms for a long time until the hardening of your arteries leads to complications. […] Arteriosclerosis disrupts normal blood flow through your body. When your arteries are too stiff, it’s harder for oxygen and nutrients to reach your organs and tissues. Therefore, hardening of the arteries can lead to complications, including: […] It’s possible to have more than one type of arteriosclerosis, and their combined effects can make problems occur sooner than usual. […] Arteriosclerosis can lead to life-threatening complications. But with early diagnosis and treatment, it’s possible to manage your condition and live a long, healthy life.

• #1 Atherosclerosis (arteriosclerosis): Causes, symptoms, and more

  https://www.medicalnewstoday.com/articles/247837

  If blood cannot circulate effectively, a person may experience numbness and pain in their limbs. In severe cases, tissue death and gangrene can occur. […] Atherosclerosis can be life threatening, but treatment is available. […] Receiving treatment early can reduce the risk of severe complications. […] The complications of atherosclerosis include: heart disease, heart attack, or heart failure, peripheral artery disease, kidney failure, aneurysm, stroke, irregular heart rhythms and palpitations, embolism when a piece of the clot breaks off and travels to another part of the bloodstream. […] Atherosclerosis is a serious condition that can have life threatening consequences. It can affect people of any age, but symptoms are most likely to appear as people get older.

• #1 Atherosclerosis – Wikipedia

  https://en.wikipedia.org/wiki/Atherosclerosis

  Symptoms of the narrowing are pain and numbness within the arms or legs. […] In 2004, US data indicated that in ~66% of men and ~47% of women, the first symptom of atherosclerotic cardiovascular disease was a heart attack or sudden cardiac death. […] Autopsy studies have shown that the prevalence of coronary artery atherosclerosis in males from the United States, with an average age of 22.1 years old, who died in war, ranges from 45% to 77.3%.

• #1 Arteriosclerosis – Wikipedia

  https://en.wikipedia.org/wiki/Arteriosclerosis

  In 2008, the US had an estimate of 16 million cases of atherosclerotic heart disease and 5.8 million strokes. Cardiovascular diseases that were caused by arteriosclerosis also caused almost 812,000 deaths in 2008, more than any other cause, including cancer. About 1.2 million Americans are predicted to have a heart attack each year.

• #1 Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol | BMC Medicine | Full Text

  https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02733-w

  Arteriosclerosis and atherosclerosis are closely related with cardiovascular disease (CVD) risk. […] This study aims to evaluate the association of RC with joint arteriosclerosis and atherosclerosis progression trajectories in the general population. […] A total of 3186 participants were included, with three clusters following distinct arteriosclerosis and atherosclerosis progression patterns identified using a multi-trajectory model. […] In the multivariable-adjusted ordinal logistics analyses, RC was significantly associated with baPWV and ABI progression (OR: 1.20; 95% CI: 1.131.28, per 10 mg/dL). […] People with a high RC level were at an increased risk of joint arteriosclerosis and atherosclerosis progression, even with optimal LDL-C. […] RC is independently associated with joint arteriosclerosis and atherosclerosis progression beyond LDL-C.

• #1 Arteriosclerosis / atherosclerosis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/diagnosis-treatment/drc-20350575

  To diagnose atherosclerosis, your healthcare professional examines you and listens to your heart. You usually are asked questions about your symptoms and your family health history. […] Your healthcare professional may hear a whooshing sound when listening to your heart with a stethoscope. […] Tests may be done to check the health of your heart and arteries. Tests can help diagnose atherosclerosis and find the cause. […] A coronary calcium scan may show coronary artery disease before you have symptoms. Results of the test are given as a score. The higher the calcium score, the higher the risk of heart attacks. […] Treatment of atherosclerosis may include: Lifestyle changes, such as eating a healthy diet and getting more exercise. […] For some people, lifestyle changes may be the only treatment needed for atherosclerosis.

• #1 Arteriosclerosis / atherosclerosis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/diagnosis-treatment/drc-20350575

  Many different medicines can slow or even reverse the effects of atherosclerosis. […] If atherosclerosis causes a severe blockage in an artery, you may need a procedure or surgery to treat it. […] It’s never too early to make healthy lifestyle changes. Eat healthy, be active, get more exercise and don’t smoke or vape. These are simple ways to protect yourself against atherosclerosis and its complications, including heart attack and stroke.

• #1 Atherosclerosis > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/atherosclerosis

  Atherosclerosis in the arteries that transport blood to the arms, legs, and pelvis can cause pain, numbness, and a tingling sensation. […] Atherosclerosis in the arteries that supply the kidneys with blood can cause high blood pressure, loss of appetite, fatigue, nausea, confusion, and swelling of the feet or legs. […] Fortunately, by making lifestyle changes, you can lower your risk of developing atherosclerosis and, if you already have atherosclerosis, stop or slow its progression. […] Studies show that lifestyle changes and getting blood pressure, cholesterol, and blood sugar levels under control can help prevent heart disease, heart attacks, and stroke.

• #1 About Peripheral Arterial Disease (PAD) | Heart Disease | CDC

  https://www.cdc.gov/heart-disease/about/peripheral-arterial-disease.html

  The classic symptom of PAD is pain in the legs with physical activity, such as walking, that gets better after rest. However, up to 4 in 10 people with PAD have no leg pain. Symptoms of pain, aches, or cramps with walking (claudication) can happen in the buttock, hip, thigh, or calf. […] Physical signs in the leg that may indicate PAD include: Muscle atrophy (weakness). Hair loss. Smooth, shiny skin. Skin that is cool to the touch, especially if there is pain while walking (that is relieved by stopping walking). Decreased or absent pulses in the feet. Sores or ulcers in the legs or feet that don’t heal. Cold or numb toes. […] If you have PAD, you are at risk for developing coronary artery disease and cerebrovascular disease, which could lead to a heart attack or stroke. […] Your doctor may recommend that you take aspirin or other similar antiplatelet medicines. These medicines could prevent serious complications from PAD and associated atherosclerosis. You may also need to take medicine to reduce your blood cholesterol. […] A supervised exercise program is recommended for people with pain caused by too little blood flow to muscles. Such a program could improve quality of life, and reduce leg symptoms.

• #1 Mayo Clinic Health Library – Arteriosclerosis / atherosclerosis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20155124

  In the arteries in your arms and legs, you may have leg pain when walking, called claudication. This is a symptom of peripheral artery disease (PAD). You also might have lower blood pressure in the affected arm or leg. […] In the arteries leading to your kidneys, you may get high blood pressure or kidney failure. […] If you think you have atherosclerosis, make an appointment for a health checkup. Early diagnosis and treatment can stop atherosclerosis from getting worse. Treatment may prevent a heart attack, stroke or another medical emergency. […] The complications of atherosclerosis depend on which arteries are narrowed or blocked. For example: Atherosclerosis in the arteries close to the heart can lead to coronary artery disease. This may cause chest pain, a heart attack or heart failure.

• #1 Atherosclerosis Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/atherosclerosis.html

  Narrowing of the leg arteries from atherosclerosis is known as peripheral artery disease. It can cause cramping pain in the leg muscles, especially during exercise. If narrowing is severe, there may be pain at rest, cold toes and feet, pale or bluish skin and hair loss on the legs. […] Atherosclerosis is a long-term condition that continues to worsen over many decades without changes in lifestyle and medication if necessary. […] Atherosclerosis leads to the number one cause of death in the United States and many other countries: cardiovascular disease. However, people with atherosclerosis are living longer with better quality of life than ever before. For many, this disease can be prevented. Even those people genetically programmed for atherosclerosis can delay the beginning and worsening of the disease with a healthy lifestyle, the right foods, and medication to lower LDL cholesterol.

• #1 New Staging System for Coronary Artery Disease

  https://cleerlyhealth.com/blog/new-staging-system-for-coronary-artery-disease

  New research proposes a four-stage system for measuring the progression of cardiovascular disease (CAD) based on atherosclerotic plaque – not secondary symptoms of heart disease. […] The staging system describes patients based on either the total plaque volume or percent atheroma volume, which is the proportion of arterial walls occupied by plaque. Stages are defined as normal (no plaque), mild, moderate, and severe plaque. […] The lack of a staging system for CAD to date has stemmed from the lack of a reliable way to measure and treat heart disease risk given the current standard of cardiovascular care. […] The next step is developing a personalized and optimal treatment plan based on the disease burden. As with cancer and common chronic conditions, this plan varies based on the stage of disease progression further emphasizing the importance of a staging system for CAD.

• #1 New Staging System for Coronary Artery Disease

  https://cleerlyhealth.com/blog/new-staging-system-for-coronary-artery-disease

  „The goal of the staging system is to be able to stage disease progression based on the primary cause of CAD – plaque – and not the secondary causes, which has been the case for decades.” […] For example, a doctor may decide to address early-stage CAD through lifestyle interventions or statin medication, as plaque buildup at that stage has not progressed enough to require a stent.

• #1 Inflammation and atherosclerosis: signaling pathways and therapeutic intervention | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-022-00955-7

  Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. […] The plaques in symptomatic patients exhibited the characterization of a distinct CD4+ T-cell subset and T cells to be activated and differentiated, whereas in the plaques from asymptomatic patients, T cells and macrophages were also activated and raised interleukin-1 (IL-1) signaling. […] Given the relationship between inflammation and atherosclerosis, treatment of atherosclerosis from an inflammatory perspective appears to be a more effective anti-atherosclerotic modality. […] Although no direct evidence supports that selectively intervention of inflammation can improve outcomes in atherosclerosis patients, clinical trials have unequivocally shown that modulation of inflammation can forestall atherosclerosis and its complications.

• #1 Inflammation and atherosclerosis: signaling pathways and therapeutic intervention | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-022-00955-7

  The detrimental effects of these macrophage-like VSMCs have been supported by the specific deletion of KLF4 (transcription factor krueppel-like factor 4) in VSMCs. […] The macrophage-like or foam-like VSMCs are pro-inflammatory and contribute to plaque vulnerability. […] The NLRP3 inflammasome is highly expressed in a variety of cell types, including innate immune cells and non-immune cells involved in the pathogenesis of the atherosclerotic cardiovascular disease. […] Previous clinical and experimental studies have demonstrated that IL-1, as a pro-atherogenic cytokine, is involved in atherosclerosis progression, suggesting that NLRP3 inflammasome is presumably a key element in atherosclerotic pathogenesis. […] The expression of NLRP3 inflammasome is increased in the plaques and peripheral blood mononuclear cells of atherosclerosis patients, which possibly reflected the severity of atherosclerosis. […] Most studies showed that monocytes promote phenotypic switching of VSMCs through activation of NLRP3 inflammasome, which exerted a likely detrimental role in the plaque stability in humans.

• #2 Arteriosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24870-arteriosclerosis

  Arteriosclerosis usually doesn’t cause symptoms until it leads to complications. Symptoms vary widely depending on the problem and can include: […] Arteriosclerosis is a gradual process that occurs over many years. It can be dangerous because it develops silently. You may have no symptoms for a long time until the hardening of your arteries leads to complications. […] Arteriosclerosis disrupts normal blood flow through your body. When your arteries are too stiff, it’s harder for oxygen and nutrients to reach your organs and tissues. Therefore, hardening of the arteries can lead to complications, including: […] It’s possible to have more than one type of arteriosclerosis, and their combined effects can make problems occur sooner than usual. […] Arteriosclerosis can lead to life-threatening complications. But with early diagnosis and treatment, it’s possible to manage your condition and live a long, healthy life.

• #2

  https://www.aurorahealthcare.org/services/heart-vascular/conditions/atherosclerosis

  Atherosclerosis can begin as early as childhood, and usually progresses more rapidly between ages 40 and 50. By age 60 about 75% of people have some degree of atherosclerosis. […] Recognizing atherosclerosis symptoms is crucial for early intervention and prevention of complications. […] Because plaque and blockages usually build up gradually and painlessly, there usually are no signs of atherosclerosis in the beginning. As atherosclerosis progresses, your signs and symptoms of hardening of the arteries depend on which arteries in your body are affected. […] If atherosclerosis is in the arteries leading to your brain, you may experience a sudden numbness or weakness in your arms or legs, difficulty speaking or slurred speech, or drooping muscles in your face, which are common atherosclerosis symptoms. […] If atherosclerosis is in your coronary (heart) arteries, you may experience chest pain, shortness of breath or heart attack. […] If atherosclerosis is in your leg arteries, you may feel pain when walking.

• #2 Atherosclerosis Vs. Arteriosclerosis: What’s The Difference?

  https://www.healthline.com/health/atherosclerosis-vs-arteriosclerosis

  Arteriosclerosis also causes no symptoms, especially in the early stages. […] Even if it progresses into hypertension, or high blood pressure, it will cause no symptoms. The only way to know if you have hypertension is to get your blood pressure measured. […] Atherosclerosis and arteriosclerosis usually cause no symptoms until they’ve led to other health conditions. […] Both conditions cause no symptoms until they progress into serious conditions.

• #2 Atherosclerosis – Heart and Blood Vessel Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/heart-and-blood-vessel-disorders/atherosclerosis/atherosclerosis

  Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or blocked blood flow. […] Often, the first symptom is pain or cramps at times when blood flow cannot keep up with the tissues’ need for oxygen. […] Progression of atherosclerosis to such life-threatening complications as a heart attack or stroke requires emergency treatment. […] With gradual narrowing, atherosclerosis usually does not cause symptoms until the interior of an artery is narrowed by more than 70%. […] The first symptom of a narrowed artery may be pain or cramps at times when blood flow cannot keep up with the tissues need for oxygen. […] If the arteries supplying the heart (coronary arteries) are blocked suddenly, a heart attack can result. Blockage in the arteries supplying the brain can cause a stroke. Blockage of the arteries in the legs can cause gangrene of a toe, foot, or leg.

• #2 Atherosclerosis Vs. Arteriosclerosis: What’s The Difference?

  https://www.healthline.com/health/atherosclerosis-vs-arteriosclerosis

  Atherosclerosis happens when these arteries become narrow due to a buildup of plaque. This can make it difficult for oxygen to reach your organs. […] Atherosclerosis is a chronic inflammatory condition that involves buildup of plaque in your arteries. This plaque is made of substances such as cholesterol and fat. […] As the plaque accumulates, it makes your arteries narrow. This lowers the flow of oxygen-rich blood to your vital organs. […] In the early stages, atherosclerosis typically causes no symptoms. […] If you do have symptoms, it usually appears when you’re physically or emotionally stressed. That’s because your body needs more oxygen during these times. […] Possible symptoms of atherosclerosis include: chest pain (angina), cold sweats, dizziness, fatigue, fast heart rate, shortness of breath, nausea, weakness, cramping in buttocks while walking, confusion (if blockage affects brain circulation), muscle weakness in legs (due to lack of circulation), pain in legs or arms.

• #2 Hardening of the arteries Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/hardening-of-the-arteries

  Atherosclerosis, sometimes called „hardening of the arteries,” occurs when fat, cholesterol, and other substances build up in the walls of arteries. These deposits are called plaques. Over time, these plaques can narrow or completely block the arteries and cause problems throughout the body. […] Atherosclerosis does not cause symptoms until blood flow to part of the body becomes slowed or blocked. If the arteries supplying the heart become narrow, blood flow can slow down or stop. This can cause chest pain (stable angina), shortness of breath, and other symptoms. […] Narrowed or blocked arteries may also cause problems in the intestines, kidneys, legs, and brain. […] Atherosclerosis cannot be reversed once it has occurred. However, lifestyle changes and treating high cholesterol levels can prevent or slow the process from becoming worse. This can help reduce the chances of having a heart attack and stroke as a result of atherosclerosis.

• #2 Atherosclerosis: Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/heart/atherosclerosis

  Atherosclerosis, the narrowing of your arteries from plaque development, happens gradually over many years, often without symptoms. […] Early stages of atherosclerosis usually do not cause any symptoms. The plaque develops slowly, and often there may be no symptoms, even at a more advanced stage. […] Symptoms of atherosclerosis depend on the affected artery or arteries and the level of their blockage. […] Atherosclerosis of the heart arteries – chest pain or pressure (angina). […] Atherosclerosis of the arteries leading to the brain – sudden numbness or weakness in your arms or legs, drooping muscles in your face, temporary loss of vision in one eye, difficulty speaking or slurred speech. […] Atherosclerosis in the arms and legs arteries – leg pain or decreased blood pressure in an affected limb. […] Atherosclerosis in the arteries leading to the kidneys – high blood pressure or kidney failure.

• #2 Atherosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16753-atherosclerosis-arterial-disease

  Atherosclerosis symptoms often dont start until an artery is very narrow or blocked. Many people dont know they have plaque buildup until they have a medical emergency like a heart attack or stroke. […] You may notice symptoms of atherosclerosis if your artery is more than 70% blocked. You can have symptoms in different parts of your body, depending on the location of the blockage. […] Coronary artery disease (CAD, which can lead to a heart attack) happens in the arteries that supply blood to your heart. […] You may experience: Shortness of breath (dyspnea) during light physical activity. Chest pain or discomfort (angina). Pain in your back, shoulders, neck, arms or belly. Feeling dizzy or lightheaded. Heart palpitations. Fatigue. Nausea or vomiting that may feel like indigestion. […] Mesenteric ischemia happens when you dont have enough blood flow in parts of your digestive system. You may experience: Pain or cramping in your belly (abdomen) after eating. Bloating, nausea and vomiting. Diarrhea. Unintentional weight loss due to food fear (fear of pain after eating).

• #2 Atherosclerosis: Symptoms, Causes, Diagnosis, and Treatment

  https://www.webmd.com/heart-disease/what-is-atherosclerosis

  Atherosclerosis usually doesn’t cause symptoms until you’re middle-aged or older. […] You might not have symptoms until your artery is nearly closed or until you have a heart attack or stroke. Symptoms can also depend on which artery is narrowed or blocked. […] Symptoms related to your coronary arteries include: Arrhythmia, an unusual heartbeat; Pain or pressure in your upper body, including your chest, arms, neck, or jaw. This is known as angina; Shortness of breath. […] Symptoms related to the arteries that deliver blood to your brain include: Numbness or weakness in your arms or legs; A hard time speaking or understanding someone who’s talking; Drooping facial muscles; Paralysis; Severe headache; Trouble seeing in one or both eyes. […] Symptoms related to the arteries of your arms, legs, and pelvis include: Leg pain when walking, called intermittent claudication; Numbness; Cold feet; Aching or burning in your toes and feet when you’re at rest; Frequent sores or infections on your feet that won’t heal. […] Symptoms related to your kidneys include: High blood pressure; Kidney failure. […] It takes years for atherosclerosis to develop into noticeable symptoms like leg and chest pain, high blood pressure, and kidney failure.

• #2 Atherosclerosis: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16753-atherosclerosis-arterial-disease

  Peripheral artery disease (PAD) refers to poor blood flow in the arteries in your limbs. […] You may experience: Muscle pain (intermittent claudication). Burning or aching pain in your feet and toes when you rest, especially when lying flat. Changes in skin color (like redness). Cool skin on your feet. Frequent skin and soft tissue infections, often in your legs or feet. Sores on your feet or toes that dont heal. […] With renal artery stenosis (narrowing of the arteries that take blood to your kidneys), you may experience: Markedly elevated blood pressure that doesnt respond to multiple medications. Changes in how often you pee. Swelling (edema). Feeling drowsy or tired. Skin that feels dry, itchy or numb. Headaches. Unexplained weight loss. Nausea, vomiting or loss of appetite. […] With carotid artery disease, the first symptoms are usually a transient ischemic attack (TIA) or stroke.

• #2 About Peripheral Arterial Disease (PAD) | Heart Disease | CDC

  https://www.cdc.gov/heart-disease/about/peripheral-arterial-disease.html

  The classic symptom of PAD is pain in the legs with physical activity, such as walking, that gets better after rest. However, up to 4 in 10 people with PAD have no leg pain. Symptoms of pain, aches, or cramps with walking (claudication) can happen in the buttock, hip, thigh, or calf. […] Physical signs in the leg that may indicate PAD include: Muscle atrophy (weakness). Hair loss. Smooth, shiny skin. Skin that is cool to the touch, especially if there is pain while walking (that is relieved by stopping walking). Decreased or absent pulses in the feet. Sores or ulcers in the legs or feet that don’t heal. Cold or numb toes. […] If you have PAD, you are at risk for developing coronary artery disease and cerebrovascular disease, which could lead to a heart attack or stroke. […] Your doctor may recommend that you take aspirin or other similar antiplatelet medicines. These medicines could prevent serious complications from PAD and associated atherosclerosis. You may also need to take medicine to reduce your blood cholesterol. […] A supervised exercise program is recommended for people with pain caused by too little blood flow to muscles. Such a program could improve quality of life, and reduce leg symptoms.

• #2 Recognizing the Signs of Artery Disease in Your Arms: Vascular Institute of New York: Board Certified Vascular and Endovascular Surgeons

  https://www.vascularnyc.com/blog/recognizing-the-signs-of-artery-disease-in-your-arms

  If the problem is allowed to continue unchecked, your muscles may begin to atrophy, or die, and your skin and nails wont be as healthy. […] This helps explain why many people with advanced arm artery disease experience persistent arm weakness or heaviness, slow-growing arm hair and fingernails, or even slow-healing sores on their hands or fingers. Some people can no longer detect a pulse on their wrist. […] At its most severe, arm artery disease can give rise to gangrene, or total tissue death. Because gangrene thats infected with bacteria can be fatal, the affected body part is usually removed, or amputated.

• #2 Atherosclerosis – Symptoms | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis/symptoms

  Peripheral artery disease includes symptoms of pain, aching, heaviness, or cramps in your legs while walking or climbing stairs. […] Vertebral artery disease includes problems with thinking and memory, weakness or numbness on one side of the body or face, and vision trouble. […] Mesenteric artery ischemia of the intestines includes severe belly pain following meals, weight loss, and diarrhea. […] Erectile dysfunction (ED) is an early warning sign that a man may be at higher risk for atherosclerosis and its complications. […] You may not notice other symptoms until plaque buildup causes serious problems. […] Carotid artery disease: Plaque builds up in the arteries of the neck. […] In early stages, you may not have any symptoms. […] Renal artery stenosis: Using a stethoscope, your provider may hear an abnormal sound, or bruit, in your belly, which is an early sign of renal artery stenosis. […] As the disease worsens, it can cause pressure, extreme tiredness, loss of appetite, nausea, feeling sick to the stomach, swelling in the hands or feet, changes in how often you need to urinate, and itchiness or numbness.

• #2 Atherosclerosis Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/atherosclerosis.html

  Atherosclerosis usually doesn’t cause any symptoms until blood supply to an organ is reduced. When this happens, symptoms vary, depending on the specific organ involved: […] Symptoms include the chest pain of angina and shortness of breath, sweating, nausea, dizziness or light-headedness, breathlessness or palpitations. […] When atherosclerosis narrows brain arteries, it can cause dizziness or confusion; weakness or paralysis on one side of the body; sudden, severe numbness in any part of the body; visual disturbance, including sudden loss of vision; difficulty walking, including staggering or veering; coordination problems in the arms and hands; and slurred speech or inability to speak. […] When atherosclerosis narrows the arteries to the intestines, there may be dull or cramping pain in the middle of the abdomen, usually beginning 15 to 30 minutes after a meal. Sudden complete blockage of an intestinal artery often causes severe abdominal pain, sometimes with vomiting, bloody stool and abdominal swelling.

• #2 Atherosclerosis (arteriosclerosis): Causes, symptoms, and more

  https://www.medicalnewstoday.com/articles/247837

  If blood cannot circulate effectively, a person may experience numbness and pain in their limbs. In severe cases, tissue death and gangrene can occur. […] Atherosclerosis can be life threatening, but treatment is available. […] Receiving treatment early can reduce the risk of severe complications. […] The complications of atherosclerosis include: heart disease, heart attack, or heart failure, peripheral artery disease, kidney failure, aneurysm, stroke, irregular heart rhythms and palpitations, embolism when a piece of the clot breaks off and travels to another part of the bloodstream. […] Atherosclerosis is a serious condition that can have life threatening consequences. It can affect people of any age, but symptoms are most likely to appear as people get older.

• #2 What is Arteriosclerosis? – Maryland Vascular Specialists

  https://mvsdoctors.com/arteriosclerosis-and-atherosclerosis-are-not-just-about-heart-disease/

  The complications of atherosclerosis depend on which arteries are blocked. For example: […] When atherosclerosis narrows the arteries close to your heart, you may develop coronary artery disease, which can cause chest pain (angina), a heart attack or heart […] When atherosclerosis narrows the arteries close to your brain, you may develop carotid artery disease, which can cause a transient ischemic attack (TIA) or […] When atherosclerosis narrows the arteries in your arms or legs, you may develop circulation problems in your arms and legs called peripheral artery disease. This can make you less sensitive to heat and cold, increasing your risk of burns or frostbite. In rare cases, poor circulation in your arms or legs can cause tissue death (gangrene). […] Atherosclerosis can also cause aneurysms, a serious complication that can occur anywhere in your body. An aneurysm is a bulge in the wall of your artery. Most people with aneurysms have no symptoms. Pain and throbbing in the area of an aneurysm may occur and is a medical emergency. If an aneurysm bursts, you may face life-threatening internal bleeding. Although this is usually a sudden, catastrophic event, a slow leak is possible. If a blood clot within an aneurysm dislodges, it may block an artery at some distant point.

• #2 Atherosclerosis (Hardening of the Arteries): Symptoms & Treatment

  https://www.emedicinehealth.com/hardening_of_the_arteries/article_em.htm

  When the arteries of the heart (coronary arteries) are affected by arteriosclerosis, the person can develop angina, heart attack, congestive heart failure, or abnormal cardiac rhythms (because of coronary artery disease). When the arteries of the brain (cerebral arteries) are affected by arteriosclerosis, the person can develop a threatened stroke, called transient ischemic attack, or actual death of brain tissue, called stroke. […] Hardening of the arteries is a progressive condition that may begin in childhood. Fatty streaks can develop in the aorta (the largest blood vessel supplying blood to both the upper and lower part of the body) shortly after birth. In those people with a familial history of high cholesterol, the condition may worsen rapidly in the early 20s and progressively become more severe in the 40s and 50s.

• #2 Atherosclerosis

  https://menomartha.com/health-topic/atherosclerosis/

  Atherosclerosis is the build-up of fatty material (atheroma) inside your arteries. Its a potentially serious condition that causes most heart attacks and strokes. […] Atherosclerosis is a common disease that develops when a sticky plaque called plaque builds up in your arteries. […] Atherosclerosis is a slow, lifelong progression of changes in the blood vessels that may start in childhood and get worse faster as you age. […] Smoking plays a big role in the progression of atherosclerosis in the aorta (the bodys main artery), coronary arteries and arteries in the legs. Smoking makes fatty deposits more likely to form, and it speeds up the growth of plaque. […] Early diagnosis and treatment can stop atherosclerosis from worsening and prevent a heart attack, stroke or another medical emergency.

• #2 Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol | BMC Medicine | Full Text

  https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02733-w

  Our findings are consistent with most previous studies. […] Our study supplemented the evidence about RC and subclinical indicators of CVD risk in the general population. […] We revealed the relationship between RC and the joint progression of baPWV and ABI for the first time from the perspective of early primary prevention of CVD. […] Our results revealed that RC plays a key role in the pathological arteriosclerosis and atherosclerosis progression, even in patients with optimal LDL-C levels. […] Our conclusions extended these prior findings and confirmed the association of RC with joint arteriosclerosis and atherosclerosis progression. […] This longitudinal study indicated that RC is an early risk factor of the joint arteriosclerosis and atherosclerosis progressions independent of LDL-C in the general population, providing new evidence on the necessity of monitoring RC for promoting cardiovascular health.

• #2 Arteriosclerosis – Wikipedia

  https://en.wikipedia.org/wiki/Arteriosclerosis

  The signs and symptoms of arteriosclerosis depend on the vessel affected by the disease. If affecting cerebral or ophthalmic vessels, as in cerebrovascular accidents or transient ischemic attacks, signs and symptoms may include sudden weakness, facial or lower limb numbness, confusion, difficulty understanding speech, and problems seeing. If affecting coronary vessels, as in coronary artery disease (including acute myocardial ischemia or a „heart attack”), signs and symptoms may include chest pain. […] Diagnosis of an individual suspected of having arteriosclerosis can be based on a physical exam, blood test, EKG and the results of these tests (among other exams). […] Treatment is often in the form of preventive measures of prophylaxis. Medical therapy is often prescribed to help prevent arteriosclerosis for underlying conditions, such as medications for the treatment of high cholesterol (e.g., statins, cholesterol absorption inhibitors), medications to treat high blood pressure (e.g., ACE inhibitors, angiotensin II receptor blockers), and antiplatelet medications. Lifestyle changes are also advised, such as increasing exercise, stopping smoking, and moderating alcohol intake.

• #2 Atherosclerosis Causes, Symptoms, and Treatment

  https://www.upmc.com/services/heart-vascular/conditions/atherosclerosis

  Atherosclerosis is a cardiovascular (heart) disease with no visible symptoms. It often remains undetected until the arteries leading to a vital organ are blocked. […] When a blockage occurs, symptoms vary depending on the location of affected arteries and may include: Chest pain (angina). Heart attack. Stroke symptoms, such as weakness or dizziness. Leg, arm, or pelvic pain (peripheral arterial disease). […] If left untreated, atherosclerosis can lead to potentially life-threatening health problems, such as heart attack and stroke. However, with proper treatment and lifestyle changes, you may be able to reduce your risk of complications from atherosclerosis and keep your condition from getting worse.

• #3 Atherosclerosis (arteriosclerosis): Causes, symptoms, and more

  https://www.medicalnewstoday.com/articles/247837

  Atherosclerosis usually affects older people, but it can start to develop during adolescence. […] Often, there are no symptoms until a bit of plaque ruptures, or the blood flow becomes restricted. This may take many years to occur. […] The symptoms of atherosclerosis depend on which arteries are affected. […] Symptoms of stroke can appear suddenly and include: weakness, difficulty breathing, headache, facial numbness, paralysis. […] When the blood supply to the heart falls, it can cause angina and heart attack. […] A person may experience: chest pain, vomiting, extreme anxiety, coughing, faintness. […] If the blood supply becomes limited, chronic kidney disease may develop. […] Someone with renal artery blockage significant enough to cause chronic kidney disease may experience: loss of appetite, swelling of the hands and feet, difficulty concentrating.

• #3 Atherosclerosis – Wikipedia

  https://en.wikipedia.org/wiki/Atherosclerosis

  Atherosclerosis is typically asymptomatic for decades because the arteries enlarge at all plaque locations, thus there is no effect on blood flow. […] At the onset there are usually no symptoms, but if they develop, symptoms generally begin around middle age. […] Signs and symptoms only happen after severe narrowing or closure impedes blood flow to different organs enough to induce symptoms. […] Marked narrowing in the coronary arteries, which are responsible for bringing oxygenated blood to the heart, can produce symptoms such as chest pain of angina and shortness of breath, sweating, nausea, dizziness or lightheadedness, breathlessness or palpitations. […] Marked narrowing of the carotid arteries can present with symptoms such as a feeling of weakness; being unable to think straight; difficulty speaking; dizziness; difficulty in walking or standing up straight; blurred vision; numbness of the face, arms and legs; severe headache; and loss of consciousness.

• #3 Atherosclerosis – Symptoms | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis/symptoms

  Early stages of atherosclerosis often do not cause symptoms. […] Symptoms may first appear when you are under physical or emotional stress times when the body needs more oxygen. […] Some people may not notice symptoms until plaque buildup causes serious problems. […] Atherosclerosis reduces the supply of oxygen-rich blood to the tissues and organs of the body. Symptoms can lower your quality of life or lead to death. […] Symptoms depend on which arteries are affected and how much blood flow is blocked. You may not notice symptoms until plaque buildup causes severe problems. […] Some conditions caused by atherosclerosis and their symptoms include the following: […] Coronary heart disease includes symptoms of chest pain (angina), heart palpitations (feeling that your heart is racing), shortness of breath, cold sweats, dizziness, extreme tiredness and weakness, and nausea.

• #3 Intracranial Atherosclerotic Disease | University of Michigan Health

  https://www.uofmhealth.org/conditions-treatments/neurointerventional-radiology/intracranial-atherosclerotic-disease

  Unfortunately, unlike atherosclerosis of the carotid arteries, which often causes transient ischemic attacks (TIA or ministrokes), intracranial atherosclerosis often is only found when a major stroke occurs. Common signs and symptoms of a stroke or TIA may include sudden: […] The patient may also experience sudden loss of consciousness and seizures. […] If you or anyone you know experiences these symptoms, emergency medical care should be sought. It is imperative for the patient to reach the hospital as quickly as possible for certain types of treatments to be successful.

• #3 Atherosclerosis – Symptoms | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis/symptoms

  Peripheral artery disease includes symptoms of pain, aching, heaviness, or cramps in your legs while walking or climbing stairs. […] Vertebral artery disease includes problems with thinking and memory, weakness or numbness on one side of the body or face, and vision trouble. […] Mesenteric artery ischemia of the intestines includes severe belly pain following meals, weight loss, and diarrhea. […] Erectile dysfunction (ED) is an early warning sign that a man may be at higher risk for atherosclerosis and its complications. […] You may not notice other symptoms until plaque buildup causes serious problems. […] Carotid artery disease: Plaque builds up in the arteries of the neck. […] In early stages, you may not have any symptoms. […] Renal artery stenosis: Using a stethoscope, your provider may hear an abnormal sound, or bruit, in your belly, which is an early sign of renal artery stenosis. […] As the disease worsens, it can cause pressure, extreme tiredness, loss of appetite, nausea, feeling sick to the stomach, swelling in the hands or feet, changes in how often you need to urinate, and itchiness or numbness.

• #3 Recognizing the Signs of Artery Disease in Your Arms: Vascular Institute of New York: Board Certified Vascular and Endovascular Surgeons

  https://www.vascularnyc.com/blog/recognizing-the-signs-of-artery-disease-in-your-arms

  Atherosclerosis can affect any artery in your body, including the main artery in your neck that supplies your brain with oxygen-rich blood (carotid artery disease) as well as the large arteries of your heart (coronary artery disease). […] PAD is the form of atherosclerosis that affects your peripheral arteries, or the arteries in your arms, pelvis, or legs. More than 10 million people in the United States live with PAD, and most experience its symptoms in their lower extremities (leg artery disease). […] In its earliest stages, PAD-related arm artery disease is a relatively silent, or hidden, disorder that doesnt cause noticeable symptoms. One of the first symptoms you may experience as it gradually progresses is intermittent claudication (IC). […] As arm artery disease continues to progress, your fingers may begin to feel uncomfortable or even painful when theyre resting. You may also experience noticeable skin changes on your fingers or hands your fingers may turn pale white or even blue, and your entire hand may become more sensitive to cold temperatures.

• #3 Atherosclerosis Symptoms | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/blood-heart-circulation/atherosclerosis/symptoms.html

  Symptoms of atherosclerosis, a heart condition where a substance called plaque builds up in the arteries, may develop gradually. As the plaque builds up, the symptoms begin to develop. Your symptoms may vary, depending on which artery is affected. If a major artery is blocked, you may experience severe symptoms, similar to those of a heart attack or stroke. […] Symptoms of a blockage in these arteries are similar to symptoms of a stroke: Weakness, Paralysis or numbness in the face, arms or legs, Confusion, Breathing problems, Dizziness, Sudden and severe headache. […] Symptoms of a blockage include numbness and pain in those areas. […] Plaque buildup can lead to chronic kidney disease. As kidney disease progresses, symptoms include: Fatigue, Changes in how often you urinate, Loss of appetite, Nausea, Itchiness or numbness.

• #3 Atherosclerosis – What Is Atherosclerosis? | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis

  A decrease in blood flow can lead to symptoms like angina. […] Full or partial blockages can cause heart attack, stroke, vascular dementia, erectile dysfunction, heart failure, or limb loss. […] Atherosclerosis can cause disability and death.

• #4 Intracranial Atherosclerotic Disease | University of Michigan Health

  https://www.uofmhealth.org/conditions-treatments/neurointerventional-radiology/intracranial-atherosclerotic-disease

  Unfortunately, unlike atherosclerosis of the carotid arteries, which often causes transient ischemic attacks (TIA or ministrokes), intracranial atherosclerosis often is only found when a major stroke occurs. Common signs and symptoms of a stroke or TIA may include sudden: […] The patient may also experience sudden loss of consciousness and seizures. […] If you or anyone you know experiences these symptoms, emergency medical care should be sought. It is imperative for the patient to reach the hospital as quickly as possible for certain types of treatments to be successful.

• #4 Atherosclerosis – Symptoms | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/atherosclerosis/symptoms

  Peripheral artery disease includes symptoms of pain, aching, heaviness, or cramps in your legs while walking or climbing stairs. […] Vertebral artery disease includes problems with thinking and memory, weakness or numbness on one side of the body or face, and vision trouble. […] Mesenteric artery ischemia of the intestines includes severe belly pain following meals, weight loss, and diarrhea. […] Erectile dysfunction (ED) is an early warning sign that a man may be at higher risk for atherosclerosis and its complications. […] You may not notice other symptoms until plaque buildup causes serious problems. […] Carotid artery disease: Plaque builds up in the arteries of the neck. […] In early stages, you may not have any symptoms. […] Renal artery stenosis: Using a stethoscope, your provider may hear an abnormal sound, or bruit, in your belly, which is an early sign of renal artery stenosis. […] As the disease worsens, it can cause pressure, extreme tiredness, loss of appetite, nausea, feeling sick to the stomach, swelling in the hands or feet, changes in how often you need to urinate, and itchiness or numbness.

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