Materiały źródłowe

• #1

  https://www.amerikanhastanesi.org/mayo-clinic-care-network/mayo-clinic-health-information-library/diseases-conditions/angiosarcoma

  Angiosarcoma signs and symptoms may vary based on where the cancer occurs. […] Most often, angiosarcoma occurs in the skin on the head and neck. It often happens on the scalp. Symptoms of this form of angiosarcoma include: A raised area of skin that looks like a bruise, A bruise-like lesion that grows larger over time, A lesion that may bleed when scratched or bumped, Swelling in the skin around the lesion. […] When angiosarcoma affects organs, such as the liver or the heart, it often causes pain. Other symptoms depend on the location of the angiosarcoma.

• #2 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma symptoms vary depending on the area of your body affected. For example, angiosarcoma of your skin (including your scalp, face, neck and breast) may look like: […] You may not notice symptoms when angiosarcoma is in an organ, like your liver, until the tumor grows big enough to impact how the organ works. Or the angiosarcoma may create pressure on nearby structures. Symptoms of angiosarcoma in an organ may include: […] An angiosarcoma may or may not cause pain. For example, angiosarcomas in your liver and spleen may cause pain in your upper abdomen, but usually not until theyve gotten big and become more advanced. Angiosarcomas on your skin may not hurt at all. Instead, they may look like a bruise that doesnt fade or spreads. […] Angiosarcomas can spread fast because they start in your blood vessels. Once its spread, angiosarcoma is very difficult to treat. Even in those cases where it goes away after treatment, it often comes back (recurs). […] About 35% of people diagnosed with angiosarcoma are alive five years after diagnosis.

• #3 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #4 Angiosarcoma – SFA

  https://curesarcoma.org/sarcoma-subtypes/angiosarcoma/

  Angiosarcoma is an aggressive, malignant vascular tumor that mimics the features of endothelial cells, affecting various body sites. […] Soft tissue angiosarcomas present as poorly defined, rapidly growing, often painful masses, occasionally associated with acute hemorrhage. Approximately one third of patients have other symptoms, such as anemia, coagulopathy, and persistent hematoma. […] Angiosarcomas of soft tissue are highly aggressive. More than half of patients die of disease within 1 year, with a local recurrence rate of 20% and distant metastases in approximately half. The most frequent site of distant metastasis is the lungs, followed by the lymph nodes, soft tissues, bone, liver, and other sites (including the brain). Older patient age, retroperitoneal location, and large size are associated with poor outcome. Factors such as epithelioid change, necrosis, and margin status, which have been shown to be prognostically significant for angiosarcomas in general, require specific validation for angiosarcomas of soft tissue. Standard sarcoma grading systems have been applied to angiosarcoma, although the correlation between histological grade and prognosis has been debated, and well-differentiated tumors often behave aggressively.

• #5

  https://www.amerikanhastanesi.org/mayo-clinic-care-network/mayo-clinic-health-information-library/diseases-conditions/angiosarcoma

  Angiosarcoma signs and symptoms may vary based on where the cancer occurs. […] Most often, angiosarcoma occurs in the skin on the head and neck. It often happens on the scalp. Symptoms of this form of angiosarcoma include: A raised area of skin that looks like a bruise, A bruise-like lesion that grows larger over time, A lesion that may bleed when scratched or bumped, Swelling in the skin around the lesion. […] When angiosarcoma affects organs, such as the liver or the heart, it often causes pain. Other symptoms depend on the location of the angiosarcoma.

• #6 Angiosarcoma | Cause, Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/a/angiosarcoma

  A common sign of angiosarcoma is a painless lump or mass in soft tissue of the body. This mass can be large or small, and can grow in size over time. The mass may be found under the skin, or deep in the muscles or other tissues. Cutaneous angiosarcoma may first appear like a bruise and can bleed easily if scratched or bumped. Very rarely, infants with angiosarcoma may have many tumors of the skin and liver at the same time. […] Angiosarcoma can be present in the body for months or even years before a patient notices a lump. […] Staging of angiosarcoma is based on the size of the tumor and whether it has spread to lymph nodes or distant sites in the body. If the tumor has not spread, it is considered to be localized. Metastatic angiosarcoma means the tumor has spread past nearby tissues to lungs or other organs. […] Many patients with angiosarcoma can be cured with surgery alone. However, angiosarcoma that has spread (metastasized) is hard to cure. Researchers are working to better understand angiosarcoma and find more effective treatment options.

• #7 Angiosarcoma: Symptoms, Causes, and Treatment Options

  https://www.tgh.org/institutes-and-services/conditions/angiosarcoma

  The symptoms of angiosarcoma can vary depending on the location of the tumor, such as: […] Most often, angiosarcoma develops on the skin of the head or neck. The most common sign is a raised patch that resembles a bruise and may be tender. The lesion may grow larger over time and cause swelling in the surrounding area. When scratched or bumped, it may bleed easily. […] Primary angiosarcoma of the breast affects people who have never been treated for breast cancer. The symptoms can include: A thickened area of breast skin, A breast lump, A rash or bruise-like lesion on the skin of the breast or upper arm. […] Secondary angiosarcoma of the breast has been linked to prior radiation treatment and lymphedema in the breast or arm. The symptoms can include: Swelling in the breast or arm, A painful lump in the breast, A rash or bruise-like lesion on the skin of the breast or upper arm.

• #8 Angiosarcoma – NCI

  https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-vascular-tumors/angiosarcoma

  Angiosarcomas often look like a bruised, purple-ish area on the skin. These areas may bleed easily when they are scratched or bumped. They grow larger over time and the skin around the bruised area can swell. […] You may have pain in the area where the tumor is growing. If the angiosarcoma is growing deeper in your body (such as in the liver), and not towards the skin’s surface, you may not notice as many symptoms. It is sometimes possible to feel the lump. […] Angiosarcoma is a fast-growing cancer, so your doctors will treat it aggressively. […] Many people with angiosarcoma aren’t diagnosed until their cancer has already spread to other parts of the body, which often results in a worse prognosis.

• #9 Angiosarcoma

  https://dermnetnz.org/topics/angiosarcoma

  Symptoms present on the skin include: Enlarging bruise, a blueblack nodule, or unhealed ulceration, Lesions may bleed and be painful, Angiosarcomas occurring on the head and neck in elderly people are one of the most common forms of cutaneous angiosarcoma. […] Angiosarcoma can also go on to affect the bones as well. Tumours may grow on multiple bones of the same extremity. Pain and tenderness of the affected area is common. Swelling and increased size of the affected limb may be present. […] Hepatic symptoms of angiosarcoma can vary and are nonspecific, and can include fatigue, weight loss and pain in the right upper quadrant. Angiosarcoma in the lungs can cause chest pain, bloody sputum, weight loss, cough, and difficulty with breathing. […] In the early stages of disease, lesions may be singular or multifocal, slow spreading patches of livid or dusky red colour, somewhat like an ill-defined bruise. Lesions may develop into elevated nodules or plaques that may bleed and ulcerate. Lesions grow rapidly and spread, making margins difficult to define. […] Despite aggressive treatment, prognosis is often poor.

• #10 Clinicopathological features and prognostic factors in angiosarcoma: A retrospective analysis of 200 patients from a single Chinese medical institute

  https://www.spandidos-publications.com/10.3892/ol.2017.6892

  Angiosarcoma is a rare type of soft tissue sarcoma with the morphological and immunohistochemical features of endothelial cells. It accounts for 14% of all soft tissue sarcoma cases. Angiosarcomas are a heterogeneous group of tumors. The primary sites of angiosarcoma include the skin, soft tissue and viscera. Clinical presentation varies considerably depending on the primary site; the majority of cutaneous angiosarcomas present as bruise-like patches, violaceous nodules or plaques, whereas angiosarcomas of soft tissue present as an enlarged painful mass. The clinical presentation of angiosarcoma of the viscera is variable, including abdominal pain, hepatosplenomegaly or anemia. […] The vast majority of head and neck angiosarcoma presented as bruise-like patches, violaceous nodules or plaques on the scalp in the present study. On progression, the lesions ulcerated and bled; patients complained of bleeding upon combing their hair. Satellite lesions were observed in certain patients. It has been reported that angiosarcoma of the head and neck in the elderly usually progresses slowly. In the present study, the interval between cutaneous lesion detection and tumor diagnosis was 1 month-40 years, with a median interval of 4.5 months. The most common symptom of angiosarcoma in soft tissue was an enlarged painful mass. Patients with primary breast angiosarcoma usually presented with a palpable mass, with rapid growth resulting in prominent enlargement of the involved breast and a bluish discoloration of the overlying skin. Patients with cardiac angiosarcoma or pulmonary angiosarcoma presented with dyspnea, cough or hemoptysis. The clinical presentation of angiosarcoma of viscera was rather variable, including abdominal pain, hepatosplenomegaly, anemia and even life-threatening hemorrhage. Pain was the most common clinical symptom of primary angiosarcoma of the bone.

• #11 Angiosarcoma: Symptoms, Causes, and Treatment Options

  https://www.tgh.org/institutes-and-services/conditions/angiosarcoma

  The symptoms of angiosarcoma can vary depending on the location of the tumor, such as: […] Most often, angiosarcoma develops on the skin of the head or neck. The most common sign is a raised patch that resembles a bruise and may be tender. The lesion may grow larger over time and cause swelling in the surrounding area. When scratched or bumped, it may bleed easily. […] Primary angiosarcoma of the breast affects people who have never been treated for breast cancer. The symptoms can include: A thickened area of breast skin, A breast lump, A rash or bruise-like lesion on the skin of the breast or upper arm. […] Secondary angiosarcoma of the breast has been linked to prior radiation treatment and lymphedema in the breast or arm. The symptoms can include: Swelling in the breast or arm, A painful lump in the breast, A rash or bruise-like lesion on the skin of the breast or upper arm.

• #12 Angiosarcoma of the breast: Symptoms and outlook

  https://www.medicalnewstoday.com/articles/angiosarcoma-of-the-breast

  Angiosarcoma of the breast is a rare, aggressive form of breast cancer. It grows rapidly and often has an unfavorable outlook due to its rarity. […] Symptoms of angiosarcoma of the breast depend on the type and whether it spreads to other body areas. […] The symptoms of primary angiosarcoma include: a feeling of fullness in the breast, discolored rash or bruise-like appearance on the skin, purple-colored nodules, which are abnormal growths in the skin, swelling of the breast, a rapidly growing breast. […] The symptoms of secondary angiosarcoma include: painful lump in the breast, eczema-like rash, discolored rash or bruise-like appearance on the skin, swelling in the breast or arm. […] The outlook for both primary and secondary angiosarcoma of the breast is often unfavorable. According to a 2017 study involving 472 participants living with angiosarcoma of the breast, the 5-year survival rate for primary angiosarcoma is 44.5%. For secondary angiosarcoma, the 5-year survival rate is much lower, at 22.5%. […] The timing of finding the cancer is also a factor, in that the earlier the tumor discovery, then the better the outlook. […] These results suggest the secondary type of this cancer has more aggressive characteristics and spreads faster.

• #13 Angiosarcoma – Rare Cancers Australia

  https://www.rarecancers.org.au/knowledgebase/cancer-types/angiosarcoma/

  Symptoms of angiosarcoma of the breast may include: A painless lump in the breast, Unexplained breast enlargement, Blue-ish skin discolouration of the breast, Change in size or shape of the breast, A change in size or shape of the nipple, A rash or bruising of the nipple, Swelling around the armpit. […] Symptoms of angiosarcoma in deep soft tissue will often vary with location. […] General symptoms of an angiosarcoma in deep soft tissue may include: A rapidly growing lump in the limbs or abdomen, Internal bleeding, Anaemia, with symptoms potentially including: Fatigue, Dizziness, Weakness, Dyspnea, Paleness, Haematomas, Lymphadenopathy. […] In addition to the symptoms above, people with an angiosarcoma in the liver may also experience: Fatigue, Unexplained weight loss/loss of appetite, Pain in the upper right abdomen.

• #14 Angiosarcoma of the Breast | Signs and Symptoms | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/angiosarcoma-of-the-breast.html

  Angiosarcoma can cause skin changes like purple colored nodules and/or a lump in the breast. […] Angiosarcomas tend to grow and spread quickly.

• #15 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  Angiosarcomas are rare endovascular-origin tumors found in all organs of the body. Approximately 8 percent of angiosarcomas arise in the breast. Primary breast angiosarcomas occur most commonly in women aged 20-40 years and typically present as an ill-defined breast mass. Secondary angiosarcomas usually occur in older women years after breast cancer treatment. They can develop in the lymphedematous upper extremity years following radical mastectomy and irradiation, a condition first described by Stewart and Treves in 1947. Secondary angiosarcomas can also arise in the chest wall following mastectomy and irradiation or in the breast after breast-conserving therapy. […] Angiosarcoma following breast conservation usually presents with skin changes that are often confused with post-irradiation skin changes or other benign conditions such as infection or trauma. Diagnostic delays are common, which may contribute to their extremely poor prognosis. Recurrence rates approach 70 percent, and the 2-year disease-free survival ranges from zero to 35 percent in various reported series.

• #16 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  Angiosarcomas are rare endovascular-origin tumors found in all organs of the body. Approximately 8 percent of angiosarcomas arise in the breast. Primary breast angiosarcomas occur most commonly in women aged 20-40 years and typically present as an ill-defined breast mass. Secondary angiosarcomas usually occur in older women years after breast cancer treatment. They can develop in the lymphedematous upper extremity years following radical mastectomy and irradiation, a condition first described by Stewart and Treves in 1947. Secondary angiosarcomas can also arise in the chest wall following mastectomy and irradiation or in the breast after breast-conserving therapy. […] Angiosarcoma following breast conservation usually presents with skin changes that are often confused with post-irradiation skin changes or other benign conditions such as infection or trauma. Diagnostic delays are common, which may contribute to their extremely poor prognosis. Recurrence rates approach 70 percent, and the 2-year disease-free survival ranges from zero to 35 percent in various reported series.

• #17 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma symptoms vary depending on the area of your body affected. For example, angiosarcoma of your skin (including your scalp, face, neck and breast) may look like: […] You may not notice symptoms when angiosarcoma is in an organ, like your liver, until the tumor grows big enough to impact how the organ works. Or the angiosarcoma may create pressure on nearby structures. Symptoms of angiosarcoma in an organ may include: […] An angiosarcoma may or may not cause pain. For example, angiosarcomas in your liver and spleen may cause pain in your upper abdomen, but usually not until theyve gotten big and become more advanced. Angiosarcomas on your skin may not hurt at all. Instead, they may look like a bruise that doesnt fade or spreads. […] Angiosarcomas can spread fast because they start in your blood vessels. Once its spread, angiosarcoma is very difficult to treat. Even in those cases where it goes away after treatment, it often comes back (recurs). […] About 35% of people diagnosed with angiosarcoma are alive five years after diagnosis.

• #18 Angiosarcoma | Cause, Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/a/angiosarcoma

  A common sign of angiosarcoma is a painless lump or mass in soft tissue of the body. This mass can be large or small, and can grow in size over time. The mass may be found under the skin, or deep in the muscles or other tissues. Cutaneous angiosarcoma may first appear like a bruise and can bleed easily if scratched or bumped. Very rarely, infants with angiosarcoma may have many tumors of the skin and liver at the same time. […] Angiosarcoma can be present in the body for months or even years before a patient notices a lump. […] Staging of angiosarcoma is based on the size of the tumor and whether it has spread to lymph nodes or distant sites in the body. If the tumor has not spread, it is considered to be localized. Metastatic angiosarcoma means the tumor has spread past nearby tissues to lungs or other organs. […] Many patients with angiosarcoma can be cured with surgery alone. However, angiosarcoma that has spread (metastasized) is hard to cure. Researchers are working to better understand angiosarcoma and find more effective treatment options.

• #19 Angiosarcoma: Symptoms, Causes, and Treatment Options

  https://www.tgh.org/institutes-and-services/conditions/angiosarcoma

  The symptoms of hepatic angiosarcoma are usually nonspecific. Some patients experience: Pain in the upper right quadrant of the abdomen, Distention of the abdomen, Jaundice, Fatigue, Unintended weight loss. […] If angiosarcoma occurs in the heart, the tumor usually forms in the upper right chamber (atrium), where it can obstruct the inflow or outflow of blood. The blockage may cause noticeable symptoms, such as swelling in the abdomen, leg, ankle or foot and distended veins in the neck.

• #20 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Regardless the controversy with respect to its side effect, conventional cytotoxic chemotherapy has been frequently used in treating inoperable and metastatic tumors. […] The prognosis of STS is disappointing, with survival rate approximately of 10 months. […] The cutaneous angiosarcoma makes up two-thirds of all cases. Due to its aggressive nature with the tendency to distant organ metastasize, the lung and brain are the most common sites of metastasize with a poor prognosis. […] Diagnosing angiosarcoma remains a challenge due to the non-specificity of presentations. Common clinical presentations include abdominal discomfort, nausea, vomiting and altered bowel habits. […] Hepatic angiosarcoma usually presents with right upper quadrant abdominal pain, jaundice and fatigue. […] As the most common sites for metastases, lung and other visceral angiosarcoma may manifest as pleural disease, pleural effusion or dyspnea.

• #21 Liver Angiosarcoma: Symptoms, Causes, Treatment, Outlook

  https://www.healthline.com/health/cancer/angiocarcinoma-liver

  Angiosarcoma of the liver is a rare and aggressive liver tumor type. It often causes no symptoms in the early stages and can be difficult to diagnose. As a result, angiosarcoma of the liver is often diagnosed in later stages, when treatment is difficult and outcomes are poor. […] Angiosarcoma of the liver causes symptoms that are easy to mistake for symptoms of many other conditions. The symptoms are nonspecific and can be very mild for some people. […] In the early stages of angiosarcoma of the liver, some people have no symptoms at all, and their cancer is discovered during tests for a different condition. […] Symptoms of angiosarcoma of the liver can include: unintentional weight loss, abdomen pain, stomach swelling, jaundice, a general feeling of being unwell, fatigue, liver swelling.

• #22 Angiosarcoma of the liver: Symptoms, treatment, and outlook

  https://www.medicalnewstoday.com/articles/angiosarcoma-liver

  Symptoms of liver angiosarcoma can vary. They are also nonspecific, meaning that other conditions have similar symptoms. A person may experience: fatigue, pain in the upper right part of the abdomen, jaundice, weight loss, bloating. […] In some cases, a person may have no symptoms, and a doctor may discover it during another exam. […] Life expectancy is not high for people diagnosed with angiosarcoma of the liver. Without treatment, most people die within 6 months. With treatment, only about 3% of people with liver angiosarcoma live more than 2 years from the date of initial diagnosis. […] A person should talk with a doctor if they notice that their skin or eyes have a yellow tint. This can indicate an issue with the liver. A person should also consider consulting a doctor if they experience pain in the upper right part of their abdomen. This can also indicate an issue with the liver. […] Liver angiosarcoma is rare, so experiencing symptoms is more likely due to another condition.

• #23 Liver Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538224/

  Angiosarcoma is described as a high-grade, malignant neoplasm of endothelial cells of blood or lymphatic vessels. Primary hepatic angiosarcoma is a rare but aggressive malignancy and the most common primary malignant mesenchymal tumor of the liver in adults. […] Hepatic angiosarcoma usually presents with nonspecific symptoms, including right upper quadrant abdominal pain, weight loss, distention, jaundice, and fatigue. The physical examination can reveal jaundice, ascites, and hepatomegaly. They can also be asymptomatic and found incidentally on imaging. […] Diagnosing hepatic angiosarcoma remains a challenge due to the nonspecificity of symptoms. […] Hepatic angiosarcoma is a rapidly growing and fatal tumor. The majority of patients die within six months of diagnosis from liver failure or hemorrhage, and most die within a year, even after surgical resection. Patients with tumor rupture often die within one month.

• #24 Cardiac Angiosarcoma: Symptoms & Outlook

  https://my.clevelandclinic.org/health/diseases/cardiac-angiosarcoma

  Cardiac angiosarcoma symptoms vary depending on the location of the tumor. […] Symptoms may include: Shortness of breath (dyspnea). Chest pain. Fatigue. Syncope (passing out). Heart palpitations. […] If the tumor spreads beyond your heart, you may have other symptoms, like anemia or weight loss. […] A tumor can return after treatment. Its common for cardiac angiosarcoma to spread to your liver, lungs and brain before you get a diagnosis. It can also spread to your bones and adrenal glands. This is what makes it a difficult cancer to treat and survive. […] The cardiac angiosarcoma prognosis is very poor. The disease aggressively invades the areas around it. The average survival time for a person with a cardiac sarcoma is about 10 to 16 months. Without surgery, most people live 9 to 12 months (even if theyve tried other kinds of treatment). […] Other estimates say survival time can be as short as 5 months or less. […] About 14% of people with a cardiac angiosarcoma diagnosis are alive five years later. Cardiac angiosarcoma that spreads (metastasizes) to other body parts is often fatal.

• #25 Cardiac Sarcoma | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cardiac-sarcoma.html

  The symptoms of heart tumors vary, depending on where the tumor is. […] Cardiac sarcomas are most often a type of sarcoma called angiosarcoma. Most angiosarcomas occur in the right upper chamber (atrium) of the heart, but they can also be found in the left atrium. The tumor blocks blood flow in and out of the chamber. This blockage may cause symptoms like chest pain and swelling of the feet, legs, ankles, or belly (abdomen). It may cause the veins in your neck to stand out (distend). This is because the blood coming back to the heart after traveling through the body cant easily go into or be pumped out of the right atrium. […] Cardiac angiosarcomas that occur on the thin sac that surrounds the heart (pericardium) can cause fluid to collect in the sac. If enough fluid builds up, it affects how well the heart can pump blood. Some signs of this buildup may include chest pain, shortness of breath, fatigue, and fluttering heartbeat (palpitations).

• #26 Angiosarcoma of the heart | Types of soft tissue sarcoma | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/soft-tissue-sarcoma/types/angiosarcoma-heart

  Symptoms can vary depending on where in the heart the cancer is. Many people dont have any symptoms until the cancer has spread to other parts of the body (advanced disease). […] Symptoms can include: breathlessness, chest pain, feeling like you want to faint or fainting, tiredness. […] When symptoms do happen, they can be similar to those caused by heart failure. They may include breathlessness, chest pain, or fluid on the lung (pleural effusion). […] Sadly, angiosarcoma of the heart often grows quickly. In most people diagnosed, the sarcoma has already spread to other parts of the body. The most common place for it to spread is the lungs. In this situation, surgery will not cure it.

• #27 Primary Cardiac Angiosarcoma – Symptoms, Treatment & Support – Without a Ribbon

  https://withoutaribbon.org/primary-cardiac-angiosarcoma-symptoms-treatment-support/

  Signs and symptoms depend on the location or part of the origination heart sarcoma. Common signs and symptoms in patients with cardiac sarcoma are […] Difficulty in breathing on exertion or any physical activity, or during sleep […] Syncope (Sudden loss of consciousness) […] Lightheadedness […] Palpitations (sensation of feeling your heartbeat) […] Cough […] Coughing up blood or blood-stained mucous […] Fever […] Night sweats […] Weight loss […] Pain in joints […] The feeling of constant tiredness […] Swelling of neck veins, legs, abdomen and ankles […] Sudden death due to cardiac arrest.

• #28 Cardiac Sarcoma | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cardiac-sarcoma.html

  The symptoms of heart tumors vary, depending on where the tumor is. […] Cardiac sarcomas are most often a type of sarcoma called angiosarcoma. Most angiosarcomas occur in the right upper chamber (atrium) of the heart, but they can also be found in the left atrium. The tumor blocks blood flow in and out of the chamber. This blockage may cause symptoms like chest pain and swelling of the feet, legs, ankles, or belly (abdomen). It may cause the veins in your neck to stand out (distend). This is because the blood coming back to the heart after traveling through the body cant easily go into or be pumped out of the right atrium. […] Cardiac angiosarcomas that occur on the thin sac that surrounds the heart (pericardium) can cause fluid to collect in the sac. If enough fluid builds up, it affects how well the heart can pump blood. Some signs of this buildup may include chest pain, shortness of breath, fatigue, and fluttering heartbeat (palpitations).

• #29 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  Cardiac angiosarcoma symptoms mirror other heart or lung problems. […] Symptoms of cardiac angiosarcoma are typical of someone with a heart or lung problem. Most patients have some degree of chest pain and shortness of breath. People note that they’re quick to get winded when doing routine activities, Ravi says. […] When experiencing these symptoms, patients often go to an emergency room and typically receive an electrocardiogram to check their hearts. However, an electrocardiogram can’t detect a mass, and because cardiac sarcomas are so rare, patients symptoms are often misdiagnosed. A 30- or 40-year-old patient will have their symptoms written off as anxiety, Ravi says. […] A mass in the heart can also be detected with an echocardiogram, but it requires a trained eye and further testing to differentiate it from more common things like a blood clot, Ravi says.

• #30 Angiosarcoma – Rare Cancers Australia

  https://www.rarecancers.org.au/knowledgebase/cancer-types/angiosarcoma/

  In addition to the symptoms above, people with an angiosarcoma in the spleen may also experience: Fever, Fatigue, Unexplained weight loss/loss of appetite, Pain in the upper right abdomen, Pain on the left side of the abdomen, Chest pain. […] In addition to the symptoms above, people with an angiosarcoma in the lungs may also experience: Chest pain, Blood in sputum, Unexplained weight loss/loss of appetite, Cough, Dyspnea. […] Symptoms of radiation-induced angiosarcoma vary by location. […] Not everyone with the symptoms above will have cancer, but see your GP if you are concerned.

• #31 Angiosarcoma

  https://dermnetnz.org/topics/angiosarcoma

  Symptoms present on the skin include: Enlarging bruise, a blueblack nodule, or unhealed ulceration, Lesions may bleed and be painful, Angiosarcomas occurring on the head and neck in elderly people are one of the most common forms of cutaneous angiosarcoma. […] Angiosarcoma can also go on to affect the bones as well. Tumours may grow on multiple bones of the same extremity. Pain and tenderness of the affected area is common. Swelling and increased size of the affected limb may be present. […] Hepatic symptoms of angiosarcoma can vary and are nonspecific, and can include fatigue, weight loss and pain in the right upper quadrant. Angiosarcoma in the lungs can cause chest pain, bloody sputum, weight loss, cough, and difficulty with breathing. […] In the early stages of disease, lesions may be singular or multifocal, slow spreading patches of livid or dusky red colour, somewhat like an ill-defined bruise. Lesions may develop into elevated nodules or plaques that may bleed and ulcerate. Lesions grow rapidly and spread, making margins difficult to define. […] Despite aggressive treatment, prognosis is often poor.

• #32 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Regardless the controversy with respect to its side effect, conventional cytotoxic chemotherapy has been frequently used in treating inoperable and metastatic tumors. […] The prognosis of STS is disappointing, with survival rate approximately of 10 months. […] The cutaneous angiosarcoma makes up two-thirds of all cases. Due to its aggressive nature with the tendency to distant organ metastasize, the lung and brain are the most common sites of metastasize with a poor prognosis. […] Diagnosing angiosarcoma remains a challenge due to the non-specificity of presentations. Common clinical presentations include abdominal discomfort, nausea, vomiting and altered bowel habits. […] Hepatic angiosarcoma usually presents with right upper quadrant abdominal pain, jaundice and fatigue. […] As the most common sites for metastases, lung and other visceral angiosarcoma may manifest as pleural disease, pleural effusion or dyspnea.

• #33 Angiosarcoma Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/276512-clinical

  Angiosarcomas are insidious, and they may not produce symptoms until the disease is well advanced. […] Angiosarcomas arising at different sites and in different organs have some distinct features, but the clinical manifestations they cause are associated with the amount of organ tissue replaced, as follows: Pathologic fractures, anemia, or hepatic dysfunction. […] Approximately 33% of patients have evidence of recent hemorrhage or coagulopathy, including anemia, persistent hematoma, hemothorax, hemorrhagic ascites, and gastrointestinal bleeding. […] Patients with soft tissue angiosarcomas usually present with a moderately paced growing mass in the extremities; the rapid progression of the disease is sometimes the clue to the diagnosis. […] Angiosarcoma of bone can affect any portion of the skeleton, although 33% of these tumors occur in the axial skeleton, 33% in long tubular bones, and the rest in the small bones of the hands and feet.

• #34 Angiosarcoma – Rare Cancers Australia

  https://www.rarecancers.org.au/knowledgebase/cancer-types/angiosarcoma/

  Symptoms of angiosarcoma of the breast may include: A painless lump in the breast, Unexplained breast enlargement, Blue-ish skin discolouration of the breast, Change in size or shape of the breast, A change in size or shape of the nipple, A rash or bruising of the nipple, Swelling around the armpit. […] Symptoms of angiosarcoma in deep soft tissue will often vary with location. […] General symptoms of an angiosarcoma in deep soft tissue may include: A rapidly growing lump in the limbs or abdomen, Internal bleeding, Anaemia, with symptoms potentially including: Fatigue, Dizziness, Weakness, Dyspnea, Paleness, Haematomas, Lymphadenopathy. […] In addition to the symptoms above, people with an angiosarcoma in the liver may also experience: Fatigue, Unexplained weight loss/loss of appetite, Pain in the upper right abdomen.

• #35 Angiosarcoma – SFA

  https://curesarcoma.org/sarcoma-subtypes/angiosarcoma/

  Angiosarcoma is an aggressive, malignant vascular tumor that mimics the features of endothelial cells, affecting various body sites. […] Soft tissue angiosarcomas present as poorly defined, rapidly growing, often painful masses, occasionally associated with acute hemorrhage. Approximately one third of patients have other symptoms, such as anemia, coagulopathy, and persistent hematoma. […] Angiosarcomas of soft tissue are highly aggressive. More than half of patients die of disease within 1 year, with a local recurrence rate of 20% and distant metastases in approximately half. The most frequent site of distant metastasis is the lungs, followed by the lymph nodes, soft tissues, bone, liver, and other sites (including the brain). Older patient age, retroperitoneal location, and large size are associated with poor outcome. Factors such as epithelioid change, necrosis, and margin status, which have been shown to be prognostically significant for angiosarcomas in general, require specific validation for angiosarcomas of soft tissue. Standard sarcoma grading systems have been applied to angiosarcoma, although the correlation between histological grade and prognosis has been debated, and well-differentiated tumors often behave aggressively.

• #36 Angiosarcoma Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/276512-clinical

  Patients do not present with specific symptoms, although pain is common and the area is frequently tender. […] Sometimes, swelling and increased size of the affected limb due to involvement of a superficial bone or to soft tissue extension characterize the presentation. […] Pathologic fractures occur in 10% of patients. […] Most patients present with an enlarging bruise, a blue-black nodule, or an unhealed ulceration. […] The rapid growth of soft tissue angiosarcomas explains why they are often misdiagnosed as abscesses and tentatively treated with drainage.

• #37 Angiosarcoma

  https://dermnetnz.org/topics/angiosarcoma

  Symptoms present on the skin include: Enlarging bruise, a blueblack nodule, or unhealed ulceration, Lesions may bleed and be painful, Angiosarcomas occurring on the head and neck in elderly people are one of the most common forms of cutaneous angiosarcoma. […] Angiosarcoma can also go on to affect the bones as well. Tumours may grow on multiple bones of the same extremity. Pain and tenderness of the affected area is common. Swelling and increased size of the affected limb may be present. […] Hepatic symptoms of angiosarcoma can vary and are nonspecific, and can include fatigue, weight loss and pain in the right upper quadrant. Angiosarcoma in the lungs can cause chest pain, bloody sputum, weight loss, cough, and difficulty with breathing. […] In the early stages of disease, lesions may be singular or multifocal, slow spreading patches of livid or dusky red colour, somewhat like an ill-defined bruise. Lesions may develop into elevated nodules or plaques that may bleed and ulcerate. Lesions grow rapidly and spread, making margins difficult to define. […] Despite aggressive treatment, prognosis is often poor.

• #38 Angiosarcoma: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/276512-overview

  More than 50% of patients develop metastatic disease, with the lung the primary organ involved. […] Angiosarcoma of the viscera (particularly liver and heart) and retroperitoneal disease are especially associated with poor outcome. […] Older patient age, retroperitoneum location, and larger tumor size are unfavorable prognostic factors. Approximately 66% of retroperitoneal angiosarcomas recur locally in the tumor bed and can recur diffusely throughout the peritoneal cavity (angiosarcomatosis). […] Despite aggressive treatment, prognosis is poor. The median survival ranges from 15-24 months, with a 5-year survival rate of 12-33%. Local failure and metastases to local cervical lymph nodes are common. The lung is the most common site of distant metastasis, followed by the liver and bone, although these tend to occur late. […] Unresectable lesions and metastatic disease at diagnosis suggest a dismal prognosis. Death can occur either from local extension or metastasis. Delayed diagnosis and treatment explain, in part, the poor prognosis of cutaneous angiosarcomas.

• #39 Angiosarcoma – Wikipedia

  https://en.wikipedia.org/wiki/Angiosarcoma

  Angiosarcoma is a rare and aggressive cancer that starts in the endothelial cells that line the walls of blood vessels or lymphatic vessels. […] Since angiosarcoma is an umbrella term for many types of tumor that vary greatly in origin and location, many symptoms may occur, from completely asymptomatic to non-specific symptoms like skin lesions, ulceration, shortness of breath and abdominal pain. […] Multiple-organ involvement at time of diagnosis is common and makes it difficult to ascertain origin and how to treat it. […] Cardiac angiosarcoma may present with shortness of breath, chest pain (46%), weight loss, anemia-like symptoms, low blood pressure and syncope. […] Angiosarcomas principally metastasises through the blood with the most common site for metastasis being the lungs; this may present as pleural effusion, pneumothorax or other pleural disease. […] Prognosis is generally very poor with a mean survival rate of three months to four years following diagnosis. […] Metastasis at time of diagnosis is common.

• #40 Cardiac Angiosarcoma: Symptoms & Outlook

  https://my.clevelandclinic.org/health/diseases/cardiac-angiosarcoma

  Cardiac angiosarcoma symptoms vary depending on the location of the tumor. […] Symptoms may include: Shortness of breath (dyspnea). Chest pain. Fatigue. Syncope (passing out). Heart palpitations. […] If the tumor spreads beyond your heart, you may have other symptoms, like anemia or weight loss. […] A tumor can return after treatment. Its common for cardiac angiosarcoma to spread to your liver, lungs and brain before you get a diagnosis. It can also spread to your bones and adrenal glands. This is what makes it a difficult cancer to treat and survive. […] The cardiac angiosarcoma prognosis is very poor. The disease aggressively invades the areas around it. The average survival time for a person with a cardiac sarcoma is about 10 to 16 months. Without surgery, most people live 9 to 12 months (even if theyve tried other kinds of treatment). […] Other estimates say survival time can be as short as 5 months or less. […] About 14% of people with a cardiac angiosarcoma diagnosis are alive five years later. Cardiac angiosarcoma that spreads (metastasizes) to other body parts is often fatal.

• #41 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  He advises patients to push their care providers to dig deeper to find explanations for the symptoms. If you aren’t seeing anything with an echocardiogram, ask for a cardiac MRI. It can be very useful in diagnosing this condition, Ravi says. […] Because the heart is the source of our blood flow, cancer cells from cardiac tumors can move throughout the body. So, at the time of diagnosis, cancer has often already spread. Most commonly, cardiac angiosarcoma spreads to the lungs, bones, liver and brain. […] Unfortunately, one in four patients sees cancer spread to the brain, so that has to be addressed first, Ravi says. […] If cancer hasn’t spread to the brain, treatment typically starts with a combination of the chemotherapy drugs doxorubicin and ifosfamide. […] The goal is to have chemotherapy shrink the primary heart tumor as well as treat sites of metastasis throughout the body.

• #42 Angiosarcoma of the Bone | Bone Cancer Research Trust

  https://www.bcrt.org.uk/information/information-by-type/angiosarcoma/

  Angiosarcomas of the Bone often grow rapidly and can sometimes present as an incidental finding, with no symptoms at all in the early stages. When a disease presents without any symptoms it is known as ‘asymptomatic’. […] When symptoms do present, they depend on the size of the tumour and the location of the tumour in the body. Pain and swelling, the most common symptoms, can often be present for months or even years before a diagnosis is made. […] The most commonly reported symptoms of an angiosarcoma of the bone are: Bone pain – this pain may be a dull ache or a stabbing sensation, Tiredness – also known as fatigue, Swelling or a lump, On rare occasions (around 10%) the tumour can cause the bone to fracture – known as a pathological fracture. […] If the tumour is located near the spine, as well causing back pain, the tumour can put pressure on the spinal cord or nerves, leading to neurological symptoms. These symptoms may include numbness or weakness when using the arms or legs and a sensation of pins and needles.

• #43 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #44 Angiosarcoma | Sarcoma UK

  https://sarcoma.org.uk/about-sarcoma/what-is-sarcoma/types-of-sarcoma/angiosarcoma/

  Angiosarcoma is an aggressive sarcoma type and can quickly spread to other parts of the body. […] Symptoms of angiosarcoma can vary depending on the size and location of your tumour. You may experience all, some or none of these symptoms before you are diagnosed with angiosarcoma: A lesion that looks like a bruise but doesnt go away and grows larger, A lesion that bleeds when disturbed, A lump or swelling in the soft tissue of the body under the skin, This lump is often fast-growing and painful.

• #45 Angiosarcoma | Cause, Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/a/angiosarcoma

  A common sign of angiosarcoma is a painless lump or mass in soft tissue of the body. This mass can be large or small, and can grow in size over time. The mass may be found under the skin, or deep in the muscles or other tissues. Cutaneous angiosarcoma may first appear like a bruise and can bleed easily if scratched or bumped. Very rarely, infants with angiosarcoma may have many tumors of the skin and liver at the same time. […] Angiosarcoma can be present in the body for months or even years before a patient notices a lump. […] Staging of angiosarcoma is based on the size of the tumor and whether it has spread to lymph nodes or distant sites in the body. If the tumor has not spread, it is considered to be localized. Metastatic angiosarcoma means the tumor has spread past nearby tissues to lungs or other organs. […] Many patients with angiosarcoma can be cured with surgery alone. However, angiosarcoma that has spread (metastasized) is hard to cure. Researchers are working to better understand angiosarcoma and find more effective treatment options.

• #46 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma symptoms vary depending on the area of your body affected. For example, angiosarcoma of your skin (including your scalp, face, neck and breast) may look like: […] You may not notice symptoms when angiosarcoma is in an organ, like your liver, until the tumor grows big enough to impact how the organ works. Or the angiosarcoma may create pressure on nearby structures. Symptoms of angiosarcoma in an organ may include: […] An angiosarcoma may or may not cause pain. For example, angiosarcomas in your liver and spleen may cause pain in your upper abdomen, but usually not until theyve gotten big and become more advanced. Angiosarcomas on your skin may not hurt at all. Instead, they may look like a bruise that doesnt fade or spreads. […] Angiosarcomas can spread fast because they start in your blood vessels. Once its spread, angiosarcoma is very difficult to treat. Even in those cases where it goes away after treatment, it often comes back (recurs). […] About 35% of people diagnosed with angiosarcoma are alive five years after diagnosis.

• #47

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/angiosarcoma

  Angiosarcoma can be aggressive and may spread to other parts of your body. […] An early sign of either type of angiosarcoma is a lump or mass in the breast that grows rapidly a common sign with other types of breast cancer. However, angiosarcoma is often diagnosed at a more advanced stage due to its rarity and similar symptoms with other breast cancers. This stresses the importance of early detection and screenings. […] Angiosarcoma can be aggressive. Your prognosis depends on several factors, including the stage of the cancer, the size and location of the tumor, whether it’s primary or secondary and the response to treatment. […] Angiosarcoma tends to have a poorer prognosis compared to more common types of breast cancer, such as invasive ductal carcinoma (IDC). […] Cancer tumors can grow quickly and may invade surrounding tissues, making them more difficult to treat. Angiosarcoma also has a high risk of recurrence, even after aggressive treatment with surgery, radiation therapy and chemotherapy.

• #48 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma symptoms vary depending on the area of your body affected. For example, angiosarcoma of your skin (including your scalp, face, neck and breast) may look like: […] You may not notice symptoms when angiosarcoma is in an organ, like your liver, until the tumor grows big enough to impact how the organ works. Or the angiosarcoma may create pressure on nearby structures. Symptoms of angiosarcoma in an organ may include: […] An angiosarcoma may or may not cause pain. For example, angiosarcomas in your liver and spleen may cause pain in your upper abdomen, but usually not until theyve gotten big and become more advanced. Angiosarcomas on your skin may not hurt at all. Instead, they may look like a bruise that doesnt fade or spreads. […] Angiosarcomas can spread fast because they start in your blood vessels. Once its spread, angiosarcoma is very difficult to treat. Even in those cases where it goes away after treatment, it often comes back (recurs). […] About 35% of people diagnosed with angiosarcoma are alive five years after diagnosis.

• #49 Angiosarcoma Cancer: Symptoms, Treatment, Outlook, and More

  https://www.healthline.com/health/cancer/angiosarcoma-cancer

  Angiosarcoma that affects your skin may have the following symptoms: a bruise or lesion that doesnt heal, a raised area of skin that grows larger over time, a lesion that bleeds when scratched or bumped, a soft lump surrounding a lesion. […] Angiosarcoma that affects other organs, like the heart or liver, may not cause any symptoms. When it grows large enough, it can start causing pain in these organs. […] Angiosarcoma is a very aggressive, fast-growing tumor. Because it starts in your blood or lymph vessels, it can spread very quickly to other tissues and organs. Once its spread, angiosarcoma is very difficult to treat. […] Angiosarcomas of the skin may look like a lesion or bruise that doesnt heal with time. […] This cancer can spread quickly into other organs and tissues, which reduces survival rates.

• #50 Angiosarcoma | Cause, Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/a/angiosarcoma

  A common sign of angiosarcoma is a painless lump or mass in soft tissue of the body. This mass can be large or small, and can grow in size over time. The mass may be found under the skin, or deep in the muscles or other tissues. Cutaneous angiosarcoma may first appear like a bruise and can bleed easily if scratched or bumped. Very rarely, infants with angiosarcoma may have many tumors of the skin and liver at the same time. […] Angiosarcoma can be present in the body for months or even years before a patient notices a lump. […] Staging of angiosarcoma is based on the size of the tumor and whether it has spread to lymph nodes or distant sites in the body. If the tumor has not spread, it is considered to be localized. Metastatic angiosarcoma means the tumor has spread past nearby tissues to lungs or other organs. […] Many patients with angiosarcoma can be cured with surgery alone. However, angiosarcoma that has spread (metastasized) is hard to cure. Researchers are working to better understand angiosarcoma and find more effective treatment options.

• #51 Angiosarcoma | Cause, Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/a/angiosarcoma

  A common sign of angiosarcoma is a painless lump or mass in soft tissue of the body. This mass can be large or small, and can grow in size over time. The mass may be found under the skin, or deep in the muscles or other tissues. Cutaneous angiosarcoma may first appear like a bruise and can bleed easily if scratched or bumped. Very rarely, infants with angiosarcoma may have many tumors of the skin and liver at the same time. […] Angiosarcoma can be present in the body for months or even years before a patient notices a lump. […] Staging of angiosarcoma is based on the size of the tumor and whether it has spread to lymph nodes or distant sites in the body. If the tumor has not spread, it is considered to be localized. Metastatic angiosarcoma means the tumor has spread past nearby tissues to lungs or other organs. […] Many patients with angiosarcoma can be cured with surgery alone. However, angiosarcoma that has spread (metastasized) is hard to cure. Researchers are working to better understand angiosarcoma and find more effective treatment options.

• #52 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #53 Angiosarcoma – Wikipedia

  https://en.wikipedia.org/wiki/Angiosarcoma

  Angiosarcoma is a rare and aggressive cancer that starts in the endothelial cells that line the walls of blood vessels or lymphatic vessels. […] Since angiosarcoma is an umbrella term for many types of tumor that vary greatly in origin and location, many symptoms may occur, from completely asymptomatic to non-specific symptoms like skin lesions, ulceration, shortness of breath and abdominal pain. […] Multiple-organ involvement at time of diagnosis is common and makes it difficult to ascertain origin and how to treat it. […] Cardiac angiosarcoma may present with shortness of breath, chest pain (46%), weight loss, anemia-like symptoms, low blood pressure and syncope. […] Angiosarcomas principally metastasises through the blood with the most common site for metastasis being the lungs; this may present as pleural effusion, pneumothorax or other pleural disease. […] Prognosis is generally very poor with a mean survival rate of three months to four years following diagnosis. […] Metastasis at time of diagnosis is common.

• #54 Angiosarcoma: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/276512-overview

  More than 50% of patients develop metastatic disease, with the lung the primary organ involved. […] Angiosarcoma of the viscera (particularly liver and heart) and retroperitoneal disease are especially associated with poor outcome. […] Older patient age, retroperitoneum location, and larger tumor size are unfavorable prognostic factors. Approximately 66% of retroperitoneal angiosarcomas recur locally in the tumor bed and can recur diffusely throughout the peritoneal cavity (angiosarcomatosis). […] Despite aggressive treatment, prognosis is poor. The median survival ranges from 15-24 months, with a 5-year survival rate of 12-33%. Local failure and metastases to local cervical lymph nodes are common. The lung is the most common site of distant metastasis, followed by the liver and bone, although these tend to occur late. […] Unresectable lesions and metastatic disease at diagnosis suggest a dismal prognosis. Death can occur either from local extension or metastasis. Delayed diagnosis and treatment explain, in part, the poor prognosis of cutaneous angiosarcomas.

• #55 Cardiac Angiosarcoma: Symptoms & Outlook

  https://my.clevelandclinic.org/health/diseases/cardiac-angiosarcoma

  Cardiac angiosarcoma symptoms vary depending on the location of the tumor. […] Symptoms may include: Shortness of breath (dyspnea). Chest pain. Fatigue. Syncope (passing out). Heart palpitations. […] If the tumor spreads beyond your heart, you may have other symptoms, like anemia or weight loss. […] A tumor can return after treatment. Its common for cardiac angiosarcoma to spread to your liver, lungs and brain before you get a diagnosis. It can also spread to your bones and adrenal glands. This is what makes it a difficult cancer to treat and survive. […] The cardiac angiosarcoma prognosis is very poor. The disease aggressively invades the areas around it. The average survival time for a person with a cardiac sarcoma is about 10 to 16 months. Without surgery, most people live 9 to 12 months (even if theyve tried other kinds of treatment). […] Other estimates say survival time can be as short as 5 months or less. […] About 14% of people with a cardiac angiosarcoma diagnosis are alive five years later. Cardiac angiosarcoma that spreads (metastasizes) to other body parts is often fatal.

• #56 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  He advises patients to push their care providers to dig deeper to find explanations for the symptoms. If you aren’t seeing anything with an echocardiogram, ask for a cardiac MRI. It can be very useful in diagnosing this condition, Ravi says. […] Because the heart is the source of our blood flow, cancer cells from cardiac tumors can move throughout the body. So, at the time of diagnosis, cancer has often already spread. Most commonly, cardiac angiosarcoma spreads to the lungs, bones, liver and brain. […] Unfortunately, one in four patients sees cancer spread to the brain, so that has to be addressed first, Ravi says. […] If cancer hasn’t spread to the brain, treatment typically starts with a combination of the chemotherapy drugs doxorubicin and ifosfamide. […] The goal is to have chemotherapy shrink the primary heart tumor as well as treat sites of metastasis throughout the body.

• #57 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  He advises patients to push their care providers to dig deeper to find explanations for the symptoms. If you aren’t seeing anything with an echocardiogram, ask for a cardiac MRI. It can be very useful in diagnosing this condition, Ravi says. […] Because the heart is the source of our blood flow, cancer cells from cardiac tumors can move throughout the body. So, at the time of diagnosis, cancer has often already spread. Most commonly, cardiac angiosarcoma spreads to the lungs, bones, liver and brain. […] Unfortunately, one in four patients sees cancer spread to the brain, so that has to be addressed first, Ravi says. […] If cancer hasn’t spread to the brain, treatment typically starts with a combination of the chemotherapy drugs doxorubicin and ifosfamide. […] The goal is to have chemotherapy shrink the primary heart tumor as well as treat sites of metastasis throughout the body.

• #58 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Overall negative surgical margins tend to improve patient survival and predict better outcome. […] Despite this limitation, overall negative surgical margins tend to improve patient survival and predict better outcome. […] Due to the aggressive nature of angiosarcomas, about 50% of patients with localized disease will develop local recrudescence and distant metastases.

• #59 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  Angiosarcomas are rare endovascular-origin tumors found in all organs of the body. Approximately 8 percent of angiosarcomas arise in the breast. Primary breast angiosarcomas occur most commonly in women aged 20-40 years and typically present as an ill-defined breast mass. Secondary angiosarcomas usually occur in older women years after breast cancer treatment. They can develop in the lymphedematous upper extremity years following radical mastectomy and irradiation, a condition first described by Stewart and Treves in 1947. Secondary angiosarcomas can also arise in the chest wall following mastectomy and irradiation or in the breast after breast-conserving therapy. […] Angiosarcoma following breast conservation usually presents with skin changes that are often confused with post-irradiation skin changes or other benign conditions such as infection or trauma. Diagnostic delays are common, which may contribute to their extremely poor prognosis. Recurrence rates approach 70 percent, and the 2-year disease-free survival ranges from zero to 35 percent in various reported series.

• #60 Angiosarcoma: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/276512-overview

  An angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces. Angiosarcomas are aggressive and tend to recur locally, spread widely, and have a high rate of lymph node and systemic metastases. The rate of tumor-related death is high. […] All angiosarcomas tend to be aggressive and are often multicentric. These tumors have high rates of local recurrence and metastasis because of their intrinsic biologic properties and because they are often misdiagnosed, leading to a poor prognosis and a high mortality rate. Malignant vascular tumors are clinically aggressive, difficult to treat, and have a reported 5-year survival rate around 20-35%. […] Advanced stage at presentation and lack of radical or wide excision are associated with higher recurrence rates, higher distant metastasis rates, and worsened survival.

• #61 Angiosarcoma: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/276512-overview

  More than 50% of patients develop metastatic disease, with the lung the primary organ involved. […] Angiosarcoma of the viscera (particularly liver and heart) and retroperitoneal disease are especially associated with poor outcome. […] Older patient age, retroperitoneum location, and larger tumor size are unfavorable prognostic factors. Approximately 66% of retroperitoneal angiosarcomas recur locally in the tumor bed and can recur diffusely throughout the peritoneal cavity (angiosarcomatosis). […] Despite aggressive treatment, prognosis is poor. The median survival ranges from 15-24 months, with a 5-year survival rate of 12-33%. Local failure and metastases to local cervical lymph nodes are common. The lung is the most common site of distant metastasis, followed by the liver and bone, although these tend to occur late. […] Unresectable lesions and metastatic disease at diagnosis suggest a dismal prognosis. Death can occur either from local extension or metastasis. Delayed diagnosis and treatment explain, in part, the poor prognosis of cutaneous angiosarcomas.

• #62 Angiosarcoma: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/276512-overview

  More than 50% of patients develop metastatic disease, with the lung the primary organ involved. […] Angiosarcoma of the viscera (particularly liver and heart) and retroperitoneal disease are especially associated with poor outcome. […] Older patient age, retroperitoneum location, and larger tumor size are unfavorable prognostic factors. Approximately 66% of retroperitoneal angiosarcomas recur locally in the tumor bed and can recur diffusely throughout the peritoneal cavity (angiosarcomatosis). […] Despite aggressive treatment, prognosis is poor. The median survival ranges from 15-24 months, with a 5-year survival rate of 12-33%. Local failure and metastases to local cervical lymph nodes are common. The lung is the most common site of distant metastasis, followed by the liver and bone, although these tend to occur late. […] Unresectable lesions and metastatic disease at diagnosis suggest a dismal prognosis. Death can occur either from local extension or metastasis. Delayed diagnosis and treatment explain, in part, the poor prognosis of cutaneous angiosarcomas.

• #63 A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival

  https://www.spandidos-publications.com/10.3892/mco.2020.2055

  Angiosarcoma is a subset of soft-tissue sarcomas with poor 5year survival rate. […] Angiosarcoma represents an aggressive subtype of sarcoma, with 12% survival at 5 years for unresectable or metastatic disease. […] The median OS for best supportive care was 2.2 months. Median OS for localized, unresectable non-metastatic and metastatic patients was 47, 5 and 3.0 months, respectively. […] Median OS for patients whose first treatment was radiation was 9 months. […] The majority of patients underwent an R0 resection (42/71). A total of 18/71 patients underwent an R1, 5/71 R2 and 6/71 were unknown. Median OS by extent of resection was 93.3, 16 and 3.4 months for R0, R1, R2 resections respectively. […] Median OS of patients treated with first line chemotherapy was 13.2 months. […] OS was significantly improved for female patients, who had resectable disease (HR=0.22, P0.01) and surgery with no residual disease (R0 vs. R1, HR=0.26, P0.01, R0 vs. R2 HR=0.07, P0.01).

• #64 Angiosarcoma Survival Rate: Everything You Need to Know

  https://my.klarity.health/angiosarcoma-survival-rate/

  Therefore, it can be said that tumors of the skin carry a better prognostic factor and vice versa for tumors affecting inner organs. […] Furthermore, the staging of the cancer can determine the prognosis. […] It is understood that late stage AS is less response to treatment especially to the taxane group of chemotherapy drugs. […] However, chemotherapy was found to be most useful when a patient presents with metastasis compared to it having less effect for patients with localized disease. […] Due to the metastatic nature of the disease the average life expectancy of patients with AS is 6 months to a year and 4 months. […] One study found that the survival rate (SR) for deep tumors was 5 months whilst for superficial ones it was 60 months. […] Moreover, it was found that patients with tumors smaller than 5cm had a SR of 60 months whilst those with tumors larger than 5cm had 10 months in comparison.

• #65 Angiosarcoma Survival Rate: Everything You Need to Know

  https://my.klarity.health/angiosarcoma-survival-rate/

  In addition, it was found that some of the patients reported an inability to raise their extremities due to the blood supply being blocked. […] For hepatic AS the symptoms can be non-specific such as tiredness or weight loss. […] On the other hand, the main presenting symptom of breast AS is a painless mass in the breast region. […] Though the symptoms for GIT AS are rare, they include abdominal pain, bleeding, and anaemia due to the blood loss. […] When talking about neoplasia it is generally considered that benign tumors carry a better prognosis than malignant ones. […] Therefore, diagnosing AS before metastasis can be incredibly beneficial. […] However, due to the rarity and non-specific early signs of this tumor it makes early diagnosis very difficult. […] A study has found that the survival time changes depending on the depth of the tumor in the body.

• #66 Angiosarcoma Survival Rate: Everything You Need to Know

  https://my.klarity.health/angiosarcoma-survival-rate/

  Therefore, it can be said that tumors of the skin carry a better prognostic factor and vice versa for tumors affecting inner organs. […] Furthermore, the staging of the cancer can determine the prognosis. […] It is understood that late stage AS is less response to treatment especially to the taxane group of chemotherapy drugs. […] However, chemotherapy was found to be most useful when a patient presents with metastasis compared to it having less effect for patients with localized disease. […] Due to the metastatic nature of the disease the average life expectancy of patients with AS is 6 months to a year and 4 months. […] One study found that the survival rate (SR) for deep tumors was 5 months whilst for superficial ones it was 60 months. […] Moreover, it was found that patients with tumors smaller than 5cm had a SR of 60 months whilst those with tumors larger than 5cm had 10 months in comparison.

• #67 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #68 Angiosarcoma of the breast: Symptoms and outlook

  https://www.medicalnewstoday.com/articles/angiosarcoma-of-the-breast

  Angiosarcoma of the breast is a rare, aggressive form of breast cancer. It grows rapidly and often has an unfavorable outlook due to its rarity. […] Symptoms of angiosarcoma of the breast depend on the type and whether it spreads to other body areas. […] The symptoms of primary angiosarcoma include: a feeling of fullness in the breast, discolored rash or bruise-like appearance on the skin, purple-colored nodules, which are abnormal growths in the skin, swelling of the breast, a rapidly growing breast. […] The symptoms of secondary angiosarcoma include: painful lump in the breast, eczema-like rash, discolored rash or bruise-like appearance on the skin, swelling in the breast or arm. […] The outlook for both primary and secondary angiosarcoma of the breast is often unfavorable. According to a 2017 study involving 472 participants living with angiosarcoma of the breast, the 5-year survival rate for primary angiosarcoma is 44.5%. For secondary angiosarcoma, the 5-year survival rate is much lower, at 22.5%. […] The timing of finding the cancer is also a factor, in that the earlier the tumor discovery, then the better the outlook. […] These results suggest the secondary type of this cancer has more aggressive characteristics and spreads faster.

• #69 Cardiac Angiosarcoma: Symptoms & Outlook

  https://my.clevelandclinic.org/health/diseases/cardiac-angiosarcoma

  Cardiac angiosarcoma symptoms vary depending on the location of the tumor. […] Symptoms may include: Shortness of breath (dyspnea). Chest pain. Fatigue. Syncope (passing out). Heart palpitations. […] If the tumor spreads beyond your heart, you may have other symptoms, like anemia or weight loss. […] A tumor can return after treatment. Its common for cardiac angiosarcoma to spread to your liver, lungs and brain before you get a diagnosis. It can also spread to your bones and adrenal glands. This is what makes it a difficult cancer to treat and survive. […] The cardiac angiosarcoma prognosis is very poor. The disease aggressively invades the areas around it. The average survival time for a person with a cardiac sarcoma is about 10 to 16 months. Without surgery, most people live 9 to 12 months (even if theyve tried other kinds of treatment). […] Other estimates say survival time can be as short as 5 months or less. […] About 14% of people with a cardiac angiosarcoma diagnosis are alive five years later. Cardiac angiosarcoma that spreads (metastasizes) to other body parts is often fatal.

• #70 Angiosarcoma of the breast: Symptoms and outlook

  https://www.medicalnewstoday.com/articles/angiosarcoma-of-the-breast

  Angiosarcoma of the breast is a rare, aggressive form of breast cancer. It grows rapidly and often has an unfavorable outlook due to its rarity. […] Symptoms of angiosarcoma of the breast depend on the type and whether it spreads to other body areas. […] The symptoms of primary angiosarcoma include: a feeling of fullness in the breast, discolored rash or bruise-like appearance on the skin, purple-colored nodules, which are abnormal growths in the skin, swelling of the breast, a rapidly growing breast. […] The symptoms of secondary angiosarcoma include: painful lump in the breast, eczema-like rash, discolored rash or bruise-like appearance on the skin, swelling in the breast or arm. […] The outlook for both primary and secondary angiosarcoma of the breast is often unfavorable. According to a 2017 study involving 472 participants living with angiosarcoma of the breast, the 5-year survival rate for primary angiosarcoma is 44.5%. For secondary angiosarcoma, the 5-year survival rate is much lower, at 22.5%. […] The timing of finding the cancer is also a factor, in that the earlier the tumor discovery, then the better the outlook. […] These results suggest the secondary type of this cancer has more aggressive characteristics and spreads faster.

• #71 Liver Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538224/

  Angiosarcoma is described as a high-grade, malignant neoplasm of endothelial cells of blood or lymphatic vessels. Primary hepatic angiosarcoma is a rare but aggressive malignancy and the most common primary malignant mesenchymal tumor of the liver in adults. […] Hepatic angiosarcoma usually presents with nonspecific symptoms, including right upper quadrant abdominal pain, weight loss, distention, jaundice, and fatigue. The physical examination can reveal jaundice, ascites, and hepatomegaly. They can also be asymptomatic and found incidentally on imaging. […] Diagnosing hepatic angiosarcoma remains a challenge due to the nonspecificity of symptoms. […] Hepatic angiosarcoma is a rapidly growing and fatal tumor. The majority of patients die within six months of diagnosis from liver failure or hemorrhage, and most die within a year, even after surgical resection. Patients with tumor rupture often die within one month.

• #72 Liver Angiosarcoma: Symptoms, Causes, Treatment, Outlook

  https://www.healthline.com/health/cancer/angiocarcinoma-liver

  Its a good idea to see a doctor or healthcare professional if you have any symptoms that might be angiosarcoma of the liver, especially if youve had them for longer than 1 or 2 weeks. […] Angiosarcoma of the liver is an aggressive and fast-growing tumor. The outlook for people with it is traditionally poor. […] Most data suggests that average survival rates are less than a year. But there is reason to think this might be changing. Recent improvements in treatments could be helping to increase the survival odds for people with angiosarcoma of the liver.

• #73 Angiosarcoma – Overview of Information and Clinical Research

  https://clinicaltrials.eu/disease/angiosarcoma/

  Angiosarcoma, a rare and aggressive cancer originating in the blood vessels, presents significant treatment challenges due to its rapid progression and complex nature. […] Angiosarcoma is a rare and aggressive cancer that poses significant challenges in treatment due to its rapid progression and complex nature. […] The prognosis for angiosarcoma is influenced by several factors, including the stage and location of the cancer, the patient’s overall health, and the type of treatment received. […] Living with angiosarcoma can be challenging due to its aggressive nature and the uncertainty surrounding its progression. […] The five-year survival rate for angiosarcoma is generally low, ranging from 30% to 38%. […] The prognosis can be particularly dire for angiosarcomas located in the heart or liver, where survival may be as short as three months.

• #74 Cardiac Angiosarcoma: Symptoms & Outlook

  https://my.clevelandclinic.org/health/diseases/cardiac-angiosarcoma

  Cardiac angiosarcoma symptoms vary depending on the location of the tumor. […] Symptoms may include: Shortness of breath (dyspnea). Chest pain. Fatigue. Syncope (passing out). Heart palpitations. […] If the tumor spreads beyond your heart, you may have other symptoms, like anemia or weight loss. […] A tumor can return after treatment. Its common for cardiac angiosarcoma to spread to your liver, lungs and brain before you get a diagnosis. It can also spread to your bones and adrenal glands. This is what makes it a difficult cancer to treat and survive. […] The cardiac angiosarcoma prognosis is very poor. The disease aggressively invades the areas around it. The average survival time for a person with a cardiac sarcoma is about 10 to 16 months. Without surgery, most people live 9 to 12 months (even if theyve tried other kinds of treatment). […] Other estimates say survival time can be as short as 5 months or less. […] About 14% of people with a cardiac angiosarcoma diagnosis are alive five years later. Cardiac angiosarcoma that spreads (metastasizes) to other body parts is often fatal.

• #75 Liver Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538224/

  It is a rapidly fatal tumor with mortality within six months from liver failure or hemorrhage. Tumor rupture may occur and result in hemoperitoneum. […] The diagnosis of hepatic angiosarcoma remains difficult during the early stages due to unspecific symptoms. Prognosis is poor due to its rapid progression, high recurrence rate, and resistance to traditional chemotherapy and radiotherapy.

• #76

  https://www.oncoscience.us/article/413/text/

  Patients with metastatic angiosarcoma undergoing chemotherapy, radiation, and/or surgery experience a median progression free survival of less than 6 months and a median overall survival of less than 12 months. […] Metastatic angiosarcoma patients face a dismal median progression free survival (PFS) of 3 to 6 months and median overall survival (OS) of 3 to 12 months. […] A prospective analysis of non-selective -AR antagonists in a single arm clinical study of metastatic angiosarcoma patients revealed that incorporation of either propranolol or carvedilol into patients treatment regimens leads to a median progression free and overall survival of 9 and 36 months, respectively. […] Patients treated with non-selective -AR antagonists were chosen for this study based on the stronger efficacy observed in our preclinical models of angiosarcoma.

• #77

  https://www.oncoscience.us/article/413/text/

  PFS and OS rates were improved in patients taking -AR antagonists relative to the historical controls. Specifically, administration of AR antagonists in combination with anti-cancer therapies resulted in a median PFS of 9 months verses previous reports of 3 to 6 months, and a median OS of 36 months verses documented reports of 12 months. […] The data presented in this study demonstrate that non-selective -AR antagonists effectively inhibit tumor cell viability and mitogenic signaling in angiosarcomas. Furthermore, incorporation of non-selective -AR antagonists into the standard treatment of patients with metastatic angiosarcoma substantially increased PFS and OS compared to historical controls.

• #78 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #79 Liver Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538224/

  Angiosarcoma is described as a high-grade, malignant neoplasm of endothelial cells of blood or lymphatic vessels. Primary hepatic angiosarcoma is a rare but aggressive malignancy and the most common primary malignant mesenchymal tumor of the liver in adults. […] Hepatic angiosarcoma usually presents with nonspecific symptoms, including right upper quadrant abdominal pain, weight loss, distention, jaundice, and fatigue. The physical examination can reveal jaundice, ascites, and hepatomegaly. They can also be asymptomatic and found incidentally on imaging. […] Diagnosing hepatic angiosarcoma remains a challenge due to the nonspecificity of symptoms. […] Hepatic angiosarcoma is a rapidly growing and fatal tumor. The majority of patients die within six months of diagnosis from liver failure or hemorrhage, and most die within a year, even after surgical resection. Patients with tumor rupture often die within one month.

• #80 Angiosarcoma – Cancer Diagnosis & Treatment Options

  https://www.leiomyosarcoma.org/angiosarcoma/

  Angiosarcoma is a malignant tumor, or cancer, of the inner lining of blood vessels. […] Angiosarcoma is usually diagnosed via X-ray, CT scan or MRI. […] There are various ways to identify angiosarcoma, including: A bruise, lesion or appearance of skin infection that does not heal; A violet colored rash that appears in area that was previously exposed to radiation (including radiation therapy); A soft lump. […] Sometimes angiosarcoma presents as deep tumors that unfortunately tend to go undetected, until they begin to affect other tissues and organs. […] Prognosis for angiosarcoma patients is poor because it is typically not diagnosed until after the disease has spread throughout the body. The late diagnosis is the primary reason that the prognosis is poor. […] Patients who have early-discovered, small tumors that are removed with large surgical margins have much better results.

• #81 Angiosarcoma: Symptoms And Current Treatment

  https://www.drrobertogarcia.com/en/angiosarcoma-symptoms-and-current-treatment/

  In internal organs, symptoms are less obvious. Pain is common, but varies depending on the organ affected. In the liver, it can cause jaundice or abdominal pain. […] Visit your doctor if you notice lesions that grow or bleed. Also if you feel unexplained pain in internal organs. Early diagnosis is key to effective treatment. Angiosarcoma accounts for 1% of cancers in adults. In children, it is more common, with 15% of cases. Early detection improves the prognosis and treatment of this aggressive cancer. […] Diagnosing angiosarcoma requires a thorough medical evaluation. Your doctor will do a physical exam and order imaging tests. X-ray helps to see masses, while CT scans locate vascular neoplasms. The MRI shows the extent and location of the vascular cancer. Ultrasound differentiates cysts from solid tumors. Positron emission tomography (PET) scans detect glucose in cancer cells. To confirm the diagnosis, a biopsy is performed.

• #82 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  Cardiac angiosarcoma symptoms mirror other heart or lung problems. […] Symptoms of cardiac angiosarcoma are typical of someone with a heart or lung problem. Most patients have some degree of chest pain and shortness of breath. People note that they’re quick to get winded when doing routine activities, Ravi says. […] When experiencing these symptoms, patients often go to an emergency room and typically receive an electrocardiogram to check their hearts. However, an electrocardiogram can’t detect a mass, and because cardiac sarcomas are so rare, patients symptoms are often misdiagnosed. A 30- or 40-year-old patient will have their symptoms written off as anxiety, Ravi says. […] A mass in the heart can also be detected with an echocardiogram, but it requires a trained eye and further testing to differentiate it from more common things like a blood clot, Ravi says.

• #83 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  He advises patients to push their care providers to dig deeper to find explanations for the symptoms. If you aren’t seeing anything with an echocardiogram, ask for a cardiac MRI. It can be very useful in diagnosing this condition, Ravi says. […] Because the heart is the source of our blood flow, cancer cells from cardiac tumors can move throughout the body. So, at the time of diagnosis, cancer has often already spread. Most commonly, cardiac angiosarcoma spreads to the lungs, bones, liver and brain. […] Unfortunately, one in four patients sees cancer spread to the brain, so that has to be addressed first, Ravi says. […] If cancer hasn’t spread to the brain, treatment typically starts with a combination of the chemotherapy drugs doxorubicin and ifosfamide. […] The goal is to have chemotherapy shrink the primary heart tumor as well as treat sites of metastasis throughout the body.

• #84 Angiosarcoma: Symptoms And Current Treatment

  https://www.drrobertogarcia.com/en/angiosarcoma-symptoms-and-current-treatment/

  In internal organs, symptoms are less obvious. Pain is common, but varies depending on the organ affected. In the liver, it can cause jaundice or abdominal pain. […] Visit your doctor if you notice lesions that grow or bleed. Also if you feel unexplained pain in internal organs. Early diagnosis is key to effective treatment. Angiosarcoma accounts for 1% of cancers in adults. In children, it is more common, with 15% of cases. Early detection improves the prognosis and treatment of this aggressive cancer. […] Diagnosing angiosarcoma requires a thorough medical evaluation. Your doctor will do a physical exam and order imaging tests. X-ray helps to see masses, while CT scans locate vascular neoplasms. The MRI shows the extent and location of the vascular cancer. Ultrasound differentiates cysts from solid tumors. Positron emission tomography (PET) scans detect glucose in cancer cells. To confirm the diagnosis, a biopsy is performed.

• #85 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #86 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Angiosarcoma is a highly malignancy of endothelial tumor and represents 1-2% of all soft tissue sarcomas in humans. […] Angiosarcoma is an easily infiltrative tumor with high rate of local recurrence and metastasis. The reported rates of advanced/metastatic disease at presentation vary from 16 to 44%, and the overall survival (OS) ranging from 6 to 16 months. […] The diagnosis of angiosarcoma remains a challenge. Due to its non-specificity of symptoms, it is difficult to discern angiosarcoma from other malignant neoplasms like anaplastic melanoma and epithelial carcinomas etc. […] Delayed diagnosis and the rarity of these tumors contribute to the difficulties in regarding best treatment and prognostic factors, radical surgery followed by adjuvant radiotherapy is thought the current optimal modality.

• #87 Angiosarcoma of the breast, the unknown—a review of the current literature – Esposito – Translational Cancer Research

  https://tcr.amegroups.org/article/view/30432/html

  Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. The lesions of primary angiosarcoma usually arise in the parenchyma of non-irradiated breast. Patient with primary angiosarcoma usually presents a rapidly growing painless and palpable mass (4 cm), rarely associated with purple blue skin discolouration. The prognosis in primary breast angiosarcoma is poor with a high risk of recurrence and metastasis. In contrast to primary breast angiosarcoma that generally affects young women, secondary breast angiosarcoma arises in older women (from 46 to 87 years), with a median of 70 years. Secondary angiosarcoma arises in the dermal and subcutaneous layers of the skin of radiated fields and may not necessarily involve the parenchyma. It is frequently associated with purple blue skin discolouration and occurs 710 years after radiation therapy. Clinically secondary angiosarcoma, especially radiation-induced angiosarcoma, affects the dermis of the breast and only occasionally develops within the breast parenchyma. This is in contrast with primary angiosarcomas, which arise within the breast parenchyma and only after involve the skin. Secondary angiosarcoma often appears as a rash, ecchymosis, or skin thickening nearby the previous cancer or surgical site. The prognosis is poor with a median overall survival (OS) of 37 months. Tumor resectability plays a central role in terms of survival. Overall survival of patients with irresectable localised disease is significantly shorter than those with resectable disease (median OS 18 vs. 37 months, P0.001, log-rank test). The diagnosis may be difficult because of easy misunderstanding with either radiodermatitis or several cutaneous diseases.

• #88 Angiosarcoma of the breast, the unknown—a review of the current literature – Esposito – Translational Cancer Research

  https://tcr.amegroups.org/article/view/30432/html

  Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. The lesions of primary angiosarcoma usually arise in the parenchyma of non-irradiated breast. Patient with primary angiosarcoma usually presents a rapidly growing painless and palpable mass (4 cm), rarely associated with purple blue skin discolouration. The prognosis in primary breast angiosarcoma is poor with a high risk of recurrence and metastasis. In contrast to primary breast angiosarcoma that generally affects young women, secondary breast angiosarcoma arises in older women (from 46 to 87 years), with a median of 70 years. Secondary angiosarcoma arises in the dermal and subcutaneous layers of the skin of radiated fields and may not necessarily involve the parenchyma. It is frequently associated with purple blue skin discolouration and occurs 710 years after radiation therapy. Clinically secondary angiosarcoma, especially radiation-induced angiosarcoma, affects the dermis of the breast and only occasionally develops within the breast parenchyma. This is in contrast with primary angiosarcomas, which arise within the breast parenchyma and only after involve the skin. Secondary angiosarcoma often appears as a rash, ecchymosis, or skin thickening nearby the previous cancer or surgical site. The prognosis is poor with a median overall survival (OS) of 37 months. Tumor resectability plays a central role in terms of survival. Overall survival of patients with irresectable localised disease is significantly shorter than those with resectable disease (median OS 18 vs. 37 months, P0.001, log-rank test). The diagnosis may be difficult because of easy misunderstanding with either radiodermatitis or several cutaneous diseases.

• #89 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  By far the most common presenting finding of post-irradiation angiosarcoma are skin changes. They can appear as focal, macular lesions or as ill-defined patches of skin discoloration ranging in color from red to blue to purple. Focal, elevated skin nodules, papules and vesicles are also common. They can be single or multiple, and can be associated with an explosive growth pattern. Another common presenting finding is skin hemorrhage which is often attributed to minor trauma. Skin erythema, another common early finding, is often confused with infection. The initial presenting findings can also be confused with post-irradiation changes. Less common presenting findings include eczematoid changes, ulcerations, bloody nipple discharge and non-pigmented macules. Most patients present with a combination of the above-described features. In approximately 10 percent of the cases a mass lesion is the dominant presenting clinical feature, but in most of these cases skin changes will be obvious. Although pain is not commonly reported in the literature, 3 of our 5 patients presented with pain prior to the onset of skin changes.

• #90 Liver Angiosarcoma: Symptoms, Causes, Treatment, Outlook

  https://www.healthline.com/health/cancer/angiocarcinoma-liver

  Angiosarcoma of the liver is a rare and aggressive liver tumor type. It often causes no symptoms in the early stages and can be difficult to diagnose. As a result, angiosarcoma of the liver is often diagnosed in later stages, when treatment is difficult and outcomes are poor. […] Angiosarcoma of the liver causes symptoms that are easy to mistake for symptoms of many other conditions. The symptoms are nonspecific and can be very mild for some people. […] In the early stages of angiosarcoma of the liver, some people have no symptoms at all, and their cancer is discovered during tests for a different condition. […] Symptoms of angiosarcoma of the liver can include: unintentional weight loss, abdomen pain, stomach swelling, jaundice, a general feeling of being unwell, fatigue, liver swelling.

• #91 Angiosarcoma of the liver: Symptoms, treatment, and outlook

  https://www.medicalnewstoday.com/articles/angiosarcoma-liver

  Symptoms of liver angiosarcoma can vary. They are also nonspecific, meaning that other conditions have similar symptoms. A person may experience: fatigue, pain in the upper right part of the abdomen, jaundice, weight loss, bloating. […] In some cases, a person may have no symptoms, and a doctor may discover it during another exam. […] Life expectancy is not high for people diagnosed with angiosarcoma of the liver. Without treatment, most people die within 6 months. With treatment, only about 3% of people with liver angiosarcoma live more than 2 years from the date of initial diagnosis. […] A person should talk with a doctor if they notice that their skin or eyes have a yellow tint. This can indicate an issue with the liver. A person should also consider consulting a doctor if they experience pain in the upper right part of their abdomen. This can also indicate an issue with the liver. […] Liver angiosarcoma is rare, so experiencing symptoms is more likely due to another condition.

• #92

  https://www.amerikanhastanesi.org/mayo-clinic-care-network/mayo-clinic-health-information-library/diseases-conditions/angiosarcoma

  Angiosarcoma signs and symptoms may vary based on where the cancer occurs. […] Most often, angiosarcoma occurs in the skin on the head and neck. It often happens on the scalp. Symptoms of this form of angiosarcoma include: A raised area of skin that looks like a bruise, A bruise-like lesion that grows larger over time, A lesion that may bleed when scratched or bumped, Swelling in the skin around the lesion. […] When angiosarcoma affects organs, such as the liver or the heart, it often causes pain. Other symptoms depend on the location of the angiosarcoma.

• #93 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma symptoms vary depending on the area of your body affected. For example, angiosarcoma of your skin (including your scalp, face, neck and breast) may look like: […] You may not notice symptoms when angiosarcoma is in an organ, like your liver, until the tumor grows big enough to impact how the organ works. Or the angiosarcoma may create pressure on nearby structures. Symptoms of angiosarcoma in an organ may include: […] An angiosarcoma may or may not cause pain. For example, angiosarcomas in your liver and spleen may cause pain in your upper abdomen, but usually not until theyve gotten big and become more advanced. Angiosarcomas on your skin may not hurt at all. Instead, they may look like a bruise that doesnt fade or spreads. […] Angiosarcomas can spread fast because they start in your blood vessels. Once its spread, angiosarcoma is very difficult to treat. Even in those cases where it goes away after treatment, it often comes back (recurs). […] About 35% of people diagnosed with angiosarcoma are alive five years after diagnosis.

• #94 Angiosarcoma – NCI

  https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-vascular-tumors/angiosarcoma

  Angiosarcomas often look like a bruised, purple-ish area on the skin. These areas may bleed easily when they are scratched or bumped. They grow larger over time and the skin around the bruised area can swell. […] You may have pain in the area where the tumor is growing. If the angiosarcoma is growing deeper in your body (such as in the liver), and not towards the skin’s surface, you may not notice as many symptoms. It is sometimes possible to feel the lump. […] Angiosarcoma is a fast-growing cancer, so your doctors will treat it aggressively. […] Many people with angiosarcoma aren’t diagnosed until their cancer has already spread to other parts of the body, which often results in a worse prognosis.

• #95 Angiosarcoma – Wikipedia

  https://en.wikipedia.org/wiki/Angiosarcoma

  Angiosarcoma is a rare and aggressive cancer that starts in the endothelial cells that line the walls of blood vessels or lymphatic vessels. […] Since angiosarcoma is an umbrella term for many types of tumor that vary greatly in origin and location, many symptoms may occur, from completely asymptomatic to non-specific symptoms like skin lesions, ulceration, shortness of breath and abdominal pain. […] Multiple-organ involvement at time of diagnosis is common and makes it difficult to ascertain origin and how to treat it. […] Cardiac angiosarcoma may present with shortness of breath, chest pain (46%), weight loss, anemia-like symptoms, low blood pressure and syncope. […] Angiosarcomas principally metastasises through the blood with the most common site for metastasis being the lungs; this may present as pleural effusion, pneumothorax or other pleural disease. […] Prognosis is generally very poor with a mean survival rate of three months to four years following diagnosis. […] Metastasis at time of diagnosis is common.

• #96 Angiosarcoma: a review of diagnosis and current treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6895451/

  Overall negative surgical margins tend to improve patient survival and predict better outcome. […] Despite this limitation, overall negative surgical margins tend to improve patient survival and predict better outcome. […] Due to the aggressive nature of angiosarcomas, about 50% of patients with localized disease will develop local recrudescence and distant metastases.

• #97 Liver Angiosarcoma: Symptoms, Causes, Treatment, Outlook

  https://www.healthline.com/health/cancer/angiocarcinoma-liver

  Angiosarcoma of the liver is a rare and aggressive liver tumor type. It often causes no symptoms in the early stages and can be difficult to diagnose. As a result, angiosarcoma of the liver is often diagnosed in later stages, when treatment is difficult and outcomes are poor. […] Angiosarcoma of the liver causes symptoms that are easy to mistake for symptoms of many other conditions. The symptoms are nonspecific and can be very mild for some people. […] In the early stages of angiosarcoma of the liver, some people have no symptoms at all, and their cancer is discovered during tests for a different condition. […] Symptoms of angiosarcoma of the liver can include: unintentional weight loss, abdomen pain, stomach swelling, jaundice, a general feeling of being unwell, fatigue, liver swelling.

• #98 A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival

  https://www.spandidos-publications.com/10.3892/mco.2020.2055

  Unresectable and metastatic angiosarcoma remains a subtype of soft tissue sarcoma with poor prognosis. […] For those with incurable disease, systemic therapy or radiation therapy offer a meaningful improvement in survival compared to best supportive care. […] Our study identified lower rates of chemotherapy usage (26%) in the incurable setting compared to most other published cohorts. […] In conclusion, this study identified that upfront surgical resection remains the most important predictor of OS in patients affected by angiosarcoma.

• #99 Angiosarcoma: Symptoms And Current Treatment

  https://www.drrobertogarcia.com/en/angiosarcoma-symptoms-and-current-treatment/

  Treatment of angiosarcoma requires a multidisciplinary approach. For stage I tumors, surgery is the primary option. Postoperative radiation therapy reduces the chances of recurrence. In stages II and III, surgery is combined with radiation therapy. For more advanced tumors, chemotherapy is crucial. Medications such as doxorubicin and ifosfamide are common options. The prognosis for metastatic angiosarcomas is reserved. Median survival is 6 to 16 months. New targeted therapies and immunotherapy are under investigation. Angiosarcoma accounts for only 1-2% of all soft tissue sarcomas. This makes it challenging to manage. The 5-year survival rate varies between 30-40%.

• #100 What is cardiac angiosarcoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/heart-cancer-cardiac-tumors-insights-on-diagnosis–treatment-and-research.h00-159543690.html

  After surgery, patients continue chemotherapy to help keep cancer from recurring. […] A recent study led by Ravi investigated the immune checkpoint inhibitor pembrolizumab in patients with cardiac angiosarcoma. We saw that pembrolizumab pushes cancer to a more chronic disease state, Ravi says. Even without curative benefit, the drug appears to slow cancers progression substantially.

Zobacz więcej