Materiały źródłowe

• #1 Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK441983/

  Angiosarcoma is a tumor of endothelial cell-origin that comprises 1% of all soft tissue sarcomas. […] This activity describes the evaluation, diagnosis, and management of angiosarcoma and highlights the role of team-based interprofessional care for affected patients. […] The best approach to patients with AS is offered in a multidisciplinary tumor board setting. […] Any patient diagnosed with STS benefits from a multidisciplinary approach. The same applies to AS. […] A multimodality approach combining surgery, radiotherapy, and chemotherapy must be used. […] Multidisciplinary tumor board discussion is a must for any patient diagnosed with angiosarcoma. […] R0 resection with perioperative RT is the best approach for local control of the disease. […] Weekly paclitaxel as a first-line treatment for AS has comparative efficacy to anthracycline-based regimens in patients with AS.

• #2 Angiosarcoma | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/17581

  Angiosarcoma (AS) comprises 1% of all soft-tissue sarcoma (STS), which are themselves a rare malignancy. […] The treatment is very challenging, and the prognosis is poor, especially if AS is diagnosed in the metastatic stage. The best approach to patients with AS is offered in a multidisciplinary tumor board setting. […] Like any other STS, surgical resection with a negative margin affords the best outcomes in terms of overall survival. […] Combining radiation therapy (RT) with weekly paclitaxel has been demonstrated to bear durable responses for cutaneous angiosarcoma. […] Doxorubicin and paclitaxel are recommended regimens for advanced or metastatic disease. […] Any patient diagnosed with STS benefits from a multidisciplinary approach. The same applies to AS. The treatment for AS can be divided based on the stage of presentation (metastatic versus non-metastatic).

• #3 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma is a very rare soft tissue tumor that forms in the inner lining of your blood or lymphatic vessels. You can develop an angiosarcoma almost anywhere in your body, but most form on your skin (especially on your head and neck or breast). Rarely, angiosarcomas form in organs. Theyre aggressive tumors that often come back after treatment. […] Learning you have angiosarcoma can feel unsettling because it can be an aggressive cancer thats hard to treat. But that doesnt mean you dont have options. Your healthcare provider can advise you on treatments based on your diagnosis. […] Surgery to remove the tumor is the most common treatment for angiosarcoma. Healthcare providers may recommend radiation therapy or chemotherapy before or after surgery to shrink tumors or kill additional cancer cells.

• #4 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Support-for-Angiosarcoma.aspx

  Angiosarcoma is a rare and aggressive disease. It is a tumor of the interior lining of the blood vessels and may occur in any part of the body. Normally, it can be found in the head and neck region, as well as in vital organs such as liver, spleen, breast, bone, and skin. Of the sarcomas listed in the surgical database Angiosarcoma constitutes about 1-2%. The disease stages decide on the relapse. […] There are different support groups available to provide valuable help and information to the people who are affected by angiosarcoma. Also their family members or neighborhood can help a lot. […] Generally, angiosarcoma patients feel lonely. Members of the family are the main support for such patients. So, they need to help the patients feel comfortable by encouraging them, changing their thinking, staying with them for a longer time, providing valuable advice for their future, and creating a supportive environment with calm.

• #5 Angiosarcoma Cancer: Symptoms, Treatment, Outlook, and More

  https://www.healthline.com/health/cancer/angiosarcoma-cancer

  Angiosarcoma is a very aggressive, fast-growing tumor. Because it starts in your blood or lymph vessels, it can spread very quickly to other tissues and organs. […] This cancer can spread quickly into other organs and tissues, which reduces survival rates. But newer treatments for angiosarcoma, such as targeted medications and immunotherapy, are promising and may extend people’s outlook.

• #6 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  Angiosarcomas are rare endovascular-origin tumors found in all organs of the body. Approximately 8 percent of angiosarcomas arise in the breast. Primary breast angiosarcomas occur most commonly in women aged 20-40 years and typically present as an ill-defined breast mass. Secondary angiosarcomas usually occur in older women years after breast cancer treatment. They can develop in the lymphedematous upper extremity years following radical mastectomy and irradiation, a condition first described by Stewart and Treves in 1947. Secondary angiosarcomas can also arise in the chest wall following mastectomy and irradiation or in the breast after breast-conserving therapy. […] Angiosarcoma following breast conservation usually presents with skin changes that are often confused with post-irradiation skin changes or other benign conditions such as infection or trauma. Diagnostic delays are common, which may contribute to their extremely poor prognosis. Recurrence rates approach 70 percent, and the 2-year disease-free survival ranges from zero to 35 percent in various reported series.

• #7 Angiosarcoma rates are rising. A new study reveals implications for breast cancer care and research.

  https://blog.swedish.org/swedish-blog/as-angiosarcoma-rates-rise-new-research-reveals-implications-for-breast-cancer-care-and-research

  The largest study of angiosarcoma published to date describes the incidence and presentation patterns of angiosarcoma, a rare but potentially deadly cancer. […] The study, published in April 2024 in JAMA, found a marked increase in angiosarcoma among women previously treated for cancer, suggesting breast cancer treatment, especially radiation, was causing many of these angiosarcomas. […] These findings suggest that breast cancer treatment (especially radiation) was causing many of these angiosarcomas. […] According to Dr. Paulson, these findings illustrate the need for further studies into the benefits and risks of regional radiation therapy. […] The hope of this ongoing research is to reduce the number of women who need radiation as part of their treatment, and, ultimately, to reduce the risk of short-term and long-term side effects including secondary cancers like angiosarcoma.

• #8 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  By far the most common presenting finding of post-irradiation angiosarcoma are skin changes. They can appear as focal, macular lesions or as ill-defined patches of skin discoloration ranging in color from red to blue to purple. Focal, elevated skin nodules, papules and vesicles are also common. They can be single or multiple, and can be associated with an explosive growth pattern. Another common presenting finding is skin hemorrhage which is often attributed to minor trauma. Skin erythema, another common early finding, is often confused with infection. The initial presenting findings can also be confused with post-irradiation changes. […] The natural history of post-irradiation angiosarcoma is dismal. The Dutch report the best results with a two-year disease free survival of 35 percent. Their favourable results may in part be related to their aggressive approach to early detection and diagnosis. Two-thirds of their patients presented to the clinic early because of skin changes or palpable masses, and in 15 of 21 patients the diagnosis was made within one month of presentation.

• #9 Angiosarcoma of the Breast | Signs and Symptoms | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/angiosarcoma-of-the-breast.html

  Angiosarcoma is a rare cancer that starts in the cells that line blood vessels or lymph vessels. It is often a complication of previous radiation treatment to the breast. It can happen 8-10 years after getting radiation treatment to the breast. […] Angiosarcoma can cause skin changes like purple colored nodules and/or a lump in the breast. It can also occur in the affected arms of women with lymphedema, but this is not common. […] Angiosarcoma is diagnosed by a biopsy, removing a small piece of the breast tissue and looking at it closely in the lab. Only a biopsy can tell for sure that it is cancer. […] Angiosarcomas tend to grow and spread quickly. Treatment usually includes surgery to remove the breast (mastectomy). The axillary lymph nodes are typically not removed. Radiation might be given in certain cases of angiosarcomas that are not related to prior breast radiation.

• #10 angiosarcoma in children | Norton Children’s

  https://nortonchildrens.com/services/cancer/conditions/sarcoma/angiosarcoma/

  Angiosarcoma in children is rare. This malignant soft tissue sarcoma most often is diagnosed in adults over age 70, but it can occur at any age. Angiosarcoma develops in the blood vessels and the vessels that carry lymphatic fluids away from lymph nodes. It is most common in the skin, breast, liver, head, neck and spleen, but can occur anywhere in the body. […] Symptoms of angiosarcoma in children depend on where the cancer is growing. If near the surface of the skin, there can be a bruised area that may bleed easily. The bruised area will get larger and can swell. Angiosarcoma growing in an organ deeper in the body may not have many symptoms, though sometimes there will be pain in the area of the tumor and you may be able to feel a lump. […] Angiosarcoma has the best chance of being cured when it’s treated by pediatric cancer specialists. Young adults may benefit from treatment at a children’s hospital instead of an adult-service hospital because of the care team’s expertise specifically in treating childhood diseases.

• #11 Putting the Extremely Rare Cardiac Angiosarcoma in the Spotlight

  https://www.onclive.com/view/putting-the-extremely-rare-cardiac-angiosarcoma-in-the-spotlight

  Angiosarcomas develop in vascular endothelial cells and can grow along preexisting vascular channels. They can also form poorly organized vessels, solid masses, or nodules. An estimated 90% of cardiac angiosarcomas appear as a multicentric mass in the right atrium of the heart. […] The difficulty with angiosarcomas, as with other cancers, is that they can hide relatively well and do not necessarily produce symptoms until they’re advanced in terms of their size, and sometimes their spread, Meyer said. Because of that, the average survival for somebody with a cardio angiosarcoma is typically not longer than a year. […] Meyer said the most common complaint associated with cardiac angiosarcoma is shortness of breath, a symptom associated with many diseases. The treating physician must be careful to rule out more common conditions, and a CT scan does not always detect masses near the heart. Electrocardiogram is a more effective tool for spotting cardiac angiosarcoma.

• #12 Angiosarcoma – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/angiosarcoma/symptoms-causes/syc-20350244

  Angiosarcoma is a rare type of cancer that forms in the lining of the blood vessels and lymph vessels. […] Treatment depends on where the cancer is located. Treatments may include surgery, radiation therapy and chemotherapy. […] Make an appointment with your health care provider if you have any persistent symptoms that worry you. […] Factors that may increase the risk of angiosarcoma include: Radiation therapy. Treatment with radiation for cancer or other conditions may increase the risk of angiosarcoma. Angiosarcoma is a rare side effect of radiation therapy. […] Swelling caused by lymph vessel damage. Swelling caused by a backup of lymph fluid is called lymphedema. It happens when the lymphatic system gets blocked or damaged. Lymphedema can happen when lymph nodes are removed during surgery. This is often done during surgery to treat cancer. Lymphedema can also happen when there is an infection or other conditions.

• #13 Angiosarcoma – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/angiosarcoma/symptoms-causes/syc-20350244

  Chemicals. Liver angiosarcoma is linked to exposure to several chemicals. Examples of these chemicals include vinyl chloride and arsenic. […] Genetic syndromes. Certain gene changes that people can be born with can raise the risk of having angiosarcoma. Examples include the gene changes that cause neurofibromatosis, Maffucci syndrome, or Klippel-Trenaunay syndrome, and the BRCA1 and BRCA2 genes.

• #14 Angiosarcoma: Symptoms, Causes, and Treatment Options

  https://www.tgh.org/institutes-and-services/conditions/angiosarcoma

  Angiosarcoma is a relatively uncommon type of tumor that originates in the lining of blood vessels and lymph vessels. Most often, this cancer develops on the surface of the skin, although it can potentially affect any part of the body, including deep tissues and organs. […] A rare and highly nuanced cancer, angiosarcoma can be challenging to diagnose and treat, so it is important to seek specialized care. […] The optimal treatment plan for angiosarcoma can vary depending on several factors, including the location and size of the tumor and whether it has spread to other areas of the body. Common options include: […] TGH’s innovative, multidisciplinary sarcoma treatment center offers personalized angiosarcoma care that is accessible to everyone.

• #15 Angiosarcoma | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/angiosarcoma

  Angiosarcoma is a type of cancer that begins in the cells that line the blood vessels or lymph vessels. […] All angiosarcomas need aggressive evaluation and treatment. […] The tumor behaves differently in each person. Usually it is very aggressive, but some tumors are low-grade (do not appear as aggressive under the microscope). All angiosarcomas need aggressive evaluation and treatment. […] Your child’s treatment team will determine a specific course of angiosarcoma treatment based on several factors, including your child’s age, overall health and medical history and the type, location, and size of the angiosarcoma. Angiosarcoma treatment options include: Surgery, Chemotherapy, Radiation therapy. […] Because angiosarcoma is so rare, very few doctors have experience diagnosing and treating it.

• #16 angiosarcoma in children | Norton Children’s

  https://nortonchildrens.com/services/cancer/conditions/sarcoma/angiosarcoma/

  Once a sarcoma is suspected, the specialists at Norton Children’s Cancer Institute may use scans such as MRI, CT scan or positron emission tomography (PET) to get information about the tumor’s size and location. […] Because angiosarcoma in children grows fast, the physician team will quickly make a plan to treat it. […] Depending on the tumor location, surgeons will remove as much of the angiosarcoma as possible. Whether the child has surgery or not, the oncologist likely will use radiation to pinpoint and destroy the tumor or any diseased cells that couldn’t be removed surgically. […] The oncologist also may use chemotherapy to attack the angiosarcoma if it metastasized to other parts of the body. Chemotherapy in conjunction with radiation therapy are often part of a treatment plan for inoperable angiosarcoma.

• #17

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/angiosarcoma

  Cancer tumors can grow quickly and may invade surrounding tissues, making them more difficult to treat. […] Angiosarcoma also has a high risk of recurrence, even after aggressive treatment with surgery, radiation therapy and chemotherapy. […] Treatment for angiosarcoma depends on various factors, including the tumor’s location, its size, grade, stage and your overall health. […] Surgery is the primary treatment for angiosarcoma. […] Your care team at Aurora Health will use a collaborative approach to provide the best treatment possible. […] Supportive care services such as counseling, nutrition therapy, palliative care and physical therapy may also be offered to help you manage the physical and emotional challenges of cancer treatment. […] Angiosarcoma of the breast can be challenging to cure due to its aggressive nature and tendency for recurrence. […] Even with aggressive treatment, the risk of local recurrence or distant spreading remains relatively high.

• #18 Angiosarcoma | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/17581

  Local surgery with R0 resection is the treatment of choice. […] AS is a high-grade malignancy. Hence peri-operative RT is always recommended. […] In patients with locally advanced cutaneous-AS, small retrospective studies have shown benefit of adding weekly paclitaxel to RT to improve local control rates and prolong survival. […] A multimodality approach combining surgery, radiotherapy, and chemotherapy must be used. […] Metastatic disease is treated with chemotherapy. […] Cytotoxic agents, targeted therapy, and Immune checkpoint inhibitors are being explored in treating metastatic disease. […] Weekly paclitaxel as a first-line treatment for AS has comparative efficacy to anthracycline-based regimens in patients with AS. […] Multidisciplinary tumor board discussion is a must for any patient diagnosed with angiosarcoma. […] R0 resection with perioperative RT is the best approach for local control of the disease. […] Despite of good local control measures, recurrence rates are high, and a close follow up with frequent imaging is mandatory.

• #19 Angiosarcoma: Symptoms, Causes, Diagnosis, Treatment

  https://www.webmd.com/cancer/what-is-angiosarcoma

  The right option for you will depend on where your cancer is located, its size, and if it has spread in your body. Treatment can be a mix of surgery, chemotherapy, and radiation. Sometimes targeted therapy and immunotherapy are given. […] Surgery is often the main treatment. The goal is to remove all of the cancer, as well as some of the healthy tissue around it. It may not be an option if the cancer is too big or has spread to other parts of your body. […] Radiation uses X-rays or other high-energy beams to kill cancer cells or stop them from growing. It’s often used after surgery to kill any leftover cancer cells. It could be an option if you can’t have surgery. […] Chemotherapy uses drugs or chemicals that are taken by mouth or injected into a vein to kill cancer cells or stop them from dividing. It may be a choice if you can’t have surgery. You sometimes get it along with radiation.

• #20 Angiosarcoma Patient Celebrates 7-Year Remission with Pioneering Use of PD-1 Inhibitor: Every Cure Unleashes AI to Ensure No Treatment is Left Overlooked – Every CureArrowShapeFacebookInstagramTwitterYoutubePlayArrow Left

  https://everycure.org/angiosarcoma-patient-celebrates-7-year-remission-with-pioneering-use-of-pd-1-inhibitor-every-cure-unleashes-ai-to-ensure-no-treatment-is-left-overlooked/

  Michael was confronted with a diagnosis of metastatic angiosarcoma and given a prognosis of just three months. […] Michael became the first patient that we were aware of at the time to be treated with a PD-1 inhibitor for angiosarcoma. It’s now been used so many times in other patients and been so effective, that it is considered standard of care, and it’s recommended by the National Comprehensive Cancer Network. […] Every Cure is committed to ensuring no potential cure remains overlooked in the vast number of medical studies performed each year. […] Our aim is to develop a new algorithm that prioritizes the potential of every drug to treat every disease. We’re ensuring that no paper containing potentially life-saving insights will ever be overlooked again and no patient is told ‘we’ve tried everything’ when a life-saving drug is sitting on the pharmacy shelf.

• #21 Advanced Angiosarcoma Care: Cabozantinib Plus Nivolumab Promise – OncologyTube

  https://oncologytube.com/advanced-angiosarcoma/

  The results have shown promising effectiveness and tolerability. […] In fact, extended follow-up data support using Nivolumab and Cabozantinib as a first-line treatment for patients with advanced angiosarcoma. […] The combination of Cabozantinib plus Nivolumab demonstrated significant anti-tumor activity in taxane-pretreated angiosarcoma patients. […] The study reported that primary disease sites were diverse, including cutaneous (scalp/face), liver, breast, among others. […] Remarkably, the combination therapy was effective across these different angiosarcoma subtypes, reinforcing its potential as a first-line treatment for advanced angiosarcoma. […] These figures, taken together, underline the promising potential of this joint treatment approach in managing advanced angiosarcoma.

• #22 High Blood Pressure Drug to Treat Angiosarcoma

  https://www.contemporaryclinic.com/view/high-blood-pressure-drug-to-treat-angiosarcoma

  Propranolol granted Orphan Drug Designation by the European Commission. […] A drug commonly used to reduce high blood pressure received Orphan Drug Designation by the European Commission (EC) to treat soft tissue sarcoma. […] The ability of propranolol to treat angiosarcoma, a lethal form of soft tissue sarcoma, was first discovered by Brad Bryan, PhD, in a study that used cell lines and animal models. […] In another study published in JAMA Dermatology in 2015, Bryan treated a patient with terminal angiosarcoma, and found that propranolol brought the tumor down to undetectable levels. […] Furthermore, there were little to no adverse events. […] Since then, some scientists around the world have tested propranolol on their own patients with angiosarcoma, and they have reported similar results.

• #23 High Blood Pressure Drug to Treat Angiosarcoma

  https://www.contemporaryclinic.com/view/high-blood-pressure-drug-to-treat-angiosarcoma

  In a study conducted by Dr Shripad Banavali, MD, and investigator Eddy Pasquier, PhD, a patient with metastatic angiosarcoma was treated with propranolol and made a full recovery. […] A year later, in a study published in EBioMedicine, investigators successfully treated 7 patients with inoperable angiosarcoma. […] What surprised us the most about this new treatment is the fact that we got 100% clinical response, which is defined as either tumor regression or stabilization of the disease, Pasquier said. […] Our ultimate objective is to have propranolol, if proven effective, fully licensed as a standard of care treatment for angiosarcoma, said Pan Pantziarka, PhD, oncology research at the Anticancer Fund. […] These 2 elements were important in making the case for the clinical potential of propranolol in this rare and hard-to-treat cancer.

• #24 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Support-for-Angiosarcoma.aspx

  A nurse, physician, or social worker is considered to be a caregiver. They should provide support to the patient by way of talking while diagnosing or treating them. They would be able to clear all the doubts that the patient may have and always stay in touch with them. […] Often giving counseling to the patients helps them to identify a safe confidential area to speak about their concerns. The caregivers should be ready with practical tips for providing care. […] Support from friends provides better and positive physical changes in patients of all age groups, which helps to improve their confidence level, and they feel more comfortable and relaxed. […] The adult support groups provide opportunity to patients to meet and share their thoughts and provide moral support. The experienced compassionate team members make the process of guiding patient discussion easier.

• #25 Effective Angiosarcoma Treatment – Options

  https://www.drrobertogarcia.com/en/effective-angiosarcoma-treatment-options/

  Treatment of angiosarcoma may include therapies such as supportive therapy and rehabilitation. These are key to improving the patient’s quality of life. It’s vital to work with a health team to find the best treatment for each one. […] Pain and symptom management is crucial. This may include medications and alternative therapies. In addition, nutritional support is essential to maintain the patient’s strength and energy. […] Rehabilitation therapies may include physical therapy, occupational therapy, and speech therapy. These help improve the patient’s mobility, strength, and function. This is how independence and quality of life are maintained. […] Treatment for angiosarcoma can be long and difficult. But it’s key to stay positive and seek support. Working with a health team is critical to a personalized treatment plan.

• #26 Angiosarcoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/22778-angiosarcoma

  Angiosarcoma is a fast-moving cancer. You can take care of yourself by slowing down. Try to give yourself time to understand whats happening to your body. Talk to your healthcare provider about steps you can take to support your treatment. […] Schedule a visit with a healthcare provider if you notice any changes to your skin. This includes nodules or sores on your scalp, face or neck that arent getting better. Reach out if youre noticing new bruising in an area where you had prior radiation therapy. […] Angiosarcoma is a very rare cancer that spreads fast. This means that if you have angiosarcoma, you may be dealing with advanced cancer. You may feel stressed about whatll happen next. Its natural to feel uncertain about the future, but you dont have to navigate this diagnosis alone. Share your concerns with your healthcare provider so they can talk you through your treatment options and prognosis.

• #27 Angiosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK441983/

  The rarity of angiosarcoma has prevented clinicians from conducting large randomized clinical trials. This is the precise reason for discussing all patients with AS in a multidisciplinary tumor board to offer them the best approach. […] Nurses, chemotherapy suites, and social workers must come together to provide comprehensive care to the patient.

• #28 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Support-for-Angiosarcoma.aspx

  There are different services available to support the cancer patients and their families financially. They can help with the payment of bills and also provision of resources for patients in essential status. […] Several cancer nutrition services are acquirable; they provide a scheduled diet plan depending on the stage of the cancer, and the diet plan has the power to deal with the side effects that arise from the treatment. The service providers also answer patients questions regarding recent findings in the field of cancer and also about the nutrition. […] Resource centers provide books, videos, brochures, Internet facilities, and CDs; satellite resource centers are staffed by professionals to aid patients to get more information regarding angiosarcoma.

• #29 Surgical Treatment of a Primary Angiosarcoma of the Breast | ACS

  https://www.facs.org/for-medical-professionals/news-publications/journals/case-reviews/issues/v4n2/14-plichta-primary-angiosarcoma-of-breast/

  Angiosarcoma is a malignant vascular neoplasm and the most common sarcoma of the breast. Primary angiosarcomas of the breast are rare tumors with a uniformly poor prognosis and ill-defined treatment guidelines. […] The management of primary breast angiosarcoma is poorly defined and largely based on retrospective case studies. Among the treatment modalities evaluated, only wide surgical resection has been shown to significantly prolong survival in localized angiosarcoma. A total mastectomy is often recommended to obtain the necessary wide margins (3 cm). […] Despite surgery, angiosarcoma of the breast has a poor prognosis with an estimated five-year overall survival of 30% to 40%. […] Primary angiosarcoma of the breast is a rare disease with a generally poor prognosis, in which surgery plays a critical role in treating localized disease. […] Upfront surgical resection with wide margins is the only potentially curative treatment for localized disease. However, patients remain at high risk of local and distant recurrence necessitating close surveillance with imaging and clinical exams.

• #30 Angiosarcomas | Breast Cancer 101 | Breastlink

  http://breastlink.com/breast-cancer-101/rare-breast-cancer-types/angiosarcomas

  Standard treatment for post-irradiation angiosarcoma is total mastectomy which is usually followed by latissimus flap closure. Regional lymph node metastasis are rare. In the absence of clinically evident metastatic disease routine axillary dissection is not indicated. Even with what appear to be adequate margins, rates of recurrence and mortality are high. Thus, in addition to wide excision, consideration should be given to adjuvant treatments. A recent report from Florida suggests that hyperfractionated irradiation may decrease rates of local recurrence. […] As the number of patients receiving breast conservation increase, it is inevitable that more cases of post-irradiation angiosarcoma will be diagnosed. Our review of the literature suggests that early detection and aggressive treatment could lead to improved outcomes.

• #31 Metronomic Chemotherapy for Advanced Cutaneous Angiosarcoma – Hematology & Oncology

  https://www.hematologyandoncology.net/archives/june-2011/metronomic-chemotherapy-for-advanced-cutaneous-angiosarcoma/

  A Novel Effective Therapy for Refractory Angiosarcoma of the Face and Scalp […] The patient was initially treated with paclitaxel 90 mg/m2 weekly. […] Weekly paclitaxel was well tolerated and effective. […] This treatment program provides an economical, effective, and nontoxic therapy in the disease relapse setting, and may warrant further testing in the frontline treatment of this challenging malignancy. […] Metronomic chemotherapy is a promising treatment modality, and larger scale prospective studies are necessary.

• #32 Advanced Angiosarcoma Care: Cabozantinib Plus Nivolumab Promise – OncologyTube

  https://oncologytube.com/advanced-angiosarcoma/

  Equally important to the effectiveness of a treatment is its safety profile. […] These findings support the tolerability of this combination therapy in the long-term treatment of advanced angiosarcoma patients. […] The absence of any Grade 4/5 treatment-related adverse events reaffirms the tolerability of the combination therapy. […] The combination of cabozantinib plus nivolumab presents a promising treatment that might not only prolong survival but also improve the quality of life of angiosarcoma patients. […] The joint use of nivolumab and Cabozantinib has shown surprisingly positive results in clinical trials. […] Achieving a response rate of 59% in the Taxol refractory population, this combination therapy far exceeded initial expectations. […] The nivolumab-Cabozantinib combination represents a significant step forward in angiosarcoma treatment. […] The treatments were well-tolerated, with toxicities similar to what you would get with these drugs by themselves. […] The promising results of the nivolumab and Cabozantinib combination therapy offer hope for patients with angiosarcoma.

• #33

  https://scholarlycommons.gbmc.org/geriatrics/1/

  Cutaneous angiosarcoma (CA) is a rare form of cancer with limited treatment options and has a very severe prognosis. […] The continuous pursuit of a diagnosis and treatment plan had to be tailored in accordance with patient goals of care. […] Careful anticipation of disease progression and complications was required following the diagnosis of CA and involved careful transition from palliation to hospice care. […] Given the aggressive nature of CA, the radical treatment required, and poor prognosis, clinical providers face a difficult task of balancing diagnostic and therapeutic steps with patient goals of care.

• #34 Malignancy Unmasked: Cutaneous Angiosarcoma Arising From Scald Burn: A Case Report – European Medical Journal

  https://www.emjreviews.com/dermatology/article/malignancy-unmasked-cutaneous-angiosarcoma-arising-from-scald-burn-a-case-report/

  Despite detailed counseling on the aggressive nature of angiosarcoma and the potential benefits of treatment, the patient chose not to proceed with the proposed management plan. […] Palliative care plays a critical role in enhancing the patients quality of life, as the prognosis for advanced cutaneous angiosarcoma remains poor. […] A multidisciplinary approach, combining surgery, radiation, chemotherapy (e.g., paclitaxel), and immuno-oncology agents, is essential for optimal treatment. […] The overall prognosis for scalp angiosarcoma is generally unfavorable, primarily due to its aggressive nature, high likelihood of local recurrence, and metastasis. […] These factors underscore the challenges in managing cutaneous angiosarcoma and emphasize the critical importance of early detection to improve survival outcomes. […] A comprehensive, patient-centered approach that integrates oncologic care with financial assistance and psychosocial support is crucial to improving treatment adherence and overall outcomes.

• #35 Childhood Angiosarcoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-angiosarcoma

  Children treated for angiosarcoma require ongoing, specialized cancer survivorship care. Patients visit a survivorship clinic annually to manage disease complications, screen for early recurrence of cancer, and manage late effects of treatment. Our pediatric cancer survivorship programs also include patient and family education, psychosocial assessment, and genetic counseling. […] The prognosis for children with localized (stage 1) angiosarcoma that can be completely surgically removed is good. However, for children with advanced angiosarcoma, the prognosis remains poor. As physician-scientists learn more about the genetic underpinnings of angiosarcoma and seek to develop drugs that target specific mutations, we hope the prognosis will improve.

• #36 Angiosarcoma – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/angiosarcoma/diagnosis-treatment/drc-20350248

  Your health care team considers the cancer’s location, its size and whether it has spread to other areas of the body. […] The goal of surgery is to remove all of the angiosarcoma. Your surgeon will remove the cancer and some of the healthy tissue that surrounds it. […] Radiation therapy uses high-energy beams, such as X-rays and protons, to kill cancer cells. […] Chemotherapy is a treatment that uses drugs or chemicals to kill cancer cells. […] Targeted drug treatments attack specific chemicals present within the cancer cells. […] Immunotherapy uses the immune system to fight cancer. […] If your provider suspects that you may have angiosarcoma, you may be referred to a specialist. […] For angiosarcoma, some basic questions to ask your provider include: How advanced is my angiosarcoma? […] Your provider is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to talk about in-depth.

• #37

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/angiosarcoma

  Angiosarcoma is a rare type of cancer that forms in the inner walls of your blood vessels or lymphatic vessels. […] Angiosarcoma cancer can be aggressive and may spread to other parts of your body. […] If you have an angiosarcoma diagnosis, our breast cancer specialists at Aurora Breast Centers are here for you every step of the way. […] We provide the latest diagnostic tests, including genetic testing, and treatments for angiosarcoma. […] Angiosarcoma can be aggressive. Your prognosis depends on several factors, including the stage of the cancer, the size and location of the tumor, whether it’s primary or secondary and the response to treatment. […] Angiosarcoma tends to have a poorer prognosis compared to more common types of breast cancer, such as invasive ductal carcinoma (IDC).

• #38 A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival

  https://www.spandidos-publications.com/10.3892/mco.2020.2055

  Angiosarcoma is a subset of soft-tissue sarcomas with poor 5-year survival rate. […] A total of 145 patients with angiosarcoma were identified, of which 68 were metastatic/unresectable at presentation. […] Of the resectable patients, 71 had first line surgery and 38 had curative intent radiation during their treatment. […] In terms of local therapy, complete oncologic resection has been shown to improve overall survival (OS). […] The effect of radiation therapy is less clear. […] OS was significantly improved for female patients, who had resectable disease and surgery with no residual disease. […] Patients who received any of chemotherapy, radiation or surgery versus best supportive care had significantly improved OS. […] Unresectable and metastatic angiosarcoma remains a subtype of soft tissue sarcoma with poor prognosis.

• #39 A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival

  https://www.spandidos-publications.com/10.3892/mco.2020.2055

  For those with incurable disease, systemic therapy or radiation therapy offer a meaningful improvement in survival compared to best supportive care. […] Local therapies such as surgery and radiation continue to impact survival. […] Appropriate upfront resection remains the most significant predictor of OS in our study and others. […] Radiation therapy use in this cohort is higher than previously published reports. […] Our study identified lower rates of chemotherapy usage in the incurable setting compared to most other published cohorts. […] Importantly, in our cohort, OS was significantly improved if any chemotherapy was used versus best supportive care. […] This study identified that upfront surgical resection remains the most important predictor of OS in patients affected by angiosarcoma. […] Unlike other published cohorts, both radiotherapy and chemotherapy statistically improved OS compared to best supportive care.

• #40 Advanced Angiosarcoma Care: Cabozantinib Plus Nivolumab Promise – OncologyTube

  https://oncologytube.com/advanced-angiosarcoma/

  Advanced Angiosarcoma (AS) is a rare and aggressive form of cancer that forms in the lining of blood vessels and lymph vessels. […] The journey of treating advanced angiosarcoma remains full of obstacles. […] One of this obstacles is the limited amount of treatment options, especially after taxane chemotherapy. […] However, the disease often returns, leading to a scenario where alternative treatment options are sorely needed. […] Furthermore, while there have been significant strides in cancer treatment over the years, sarcomas, including angiosarcoma, have demonstrated less benefit from immunotherapy than many other cancers. […] This is primarily due to the diverse nature of sarcomas, requiring more personalized treatment approaches. […] The treatment of advanced angiosarcoma with Nivolumab plus Cabozantinib has been subject to such scrutiny.

• #41 Dr. Wagner on the Standard of Care in Angiosarcoma

  https://www.onclive.com/view/dr-wagner-on-the-standard-of-care-in-angiosarcoma

  Michael J. Wagner, MD, discusses the standard of care for patients with angiosarcoma. […] There is no established standard of care for angiosarcoma, according to Wagner. Part of the problem is that it is difficult to conduct large clinical trials with such a small patient population, Wagner says. […] If the patient is eligible for surgery, angiosarcoma should be removed, Wagner adds. Chemoradiation is often administered, especially for patients with localized disease. Chemotherapy or targeted agents may be an option for those with metastatic angiosarcoma, Wagner concludes.

• #42 High Blood Pressure Drug to Treat Angiosarcoma

  https://www.contemporaryclinic.com/view/high-blood-pressure-drug-to-treat-angiosarcoma

  As the high cost of drugs continues to stir criticism, propranolol could potentially offer a cheaper treatment option for patients with angiosarcoma. […] Propranolol is a generic drug that costs approximately $4 per month. […] While propranolol will certainly not replace these treatments, our data show it improves the ability of the treatments to work—all at the cost of a generic copay. […] Recently, the Anticancer Fund formed the Propranolol for Angiosarcoma Task Force to bring together scientists and clinicians who are interested in further developing propranolol treatment options.

• #43 Clinical implications of systemic and local immune responses in human angiosarcoma | npj Precision Oncology

  https://www.nature.com/articles/s41698-021-00150-x

  Consistent with the observation that palliative chemotherapy improves survival outcomes, responses to first-line palliative chemotherapy were correlated with improved OS. […] A deeper understanding of the immune and oncogenic signaling pathways involved in their pathobiology may provide clues to overcome chemoresistance and improve patient outcomes in this devastating disease.

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