Materiały źródłowe

• #1 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists.

• #2

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #3 Salivary gland cancer — epidemiology | Kordzińska-Cisek | Nowotwory. Journal of Oncology

  https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/58955

  Salivary gland tumors represent 311% of all head and neck cancers and 0.2% of all neoplasms. Among Poles, malignancies involving the large salivary glands constituted 0.3% of all malignancies in Poland and 9.7% of head and neck neoplasms. In 2014, the morbidity rate was higher among women, but over the past 15 years there has been a slight prevalence among men. […] Salivary gland neoplasms are usually located in the parotid gland, then in the sub-mandibular gland. The best prognosis is for women whose cancers are located in the parotid gland and those with lobular carcinoma. Figures have been on the rise lately, however. Deaths have been on a stable level.

• #4 Salivary Gland Neoplasms: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/852373-overview

  Salivary gland neoplasms make up 6% of all head and neck tumors. The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. Mortality from malignant salivary gland neoplasms varies by stage and pathology, but the overall 5-year survival rate is 72%. […] Salivary gland neoplasms most commonly appear in the sixth decade of life. Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. […] Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. […] Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands.

• #5 Epidemiology of Benign Salivary Gland Neoplasms | Pocket Dentistry

  https://pocketdentistry.com/epidemiology-of-benign-salivary-gland-neoplasms/

  Benign tumors of the salivary glands represent the majority of salivary gland diseases. […] Determining the true incidence of benign salivary gland tumors in populations is made difficult by the fact that there is no indication for establishing registries such as those available for malignant disease. […] The true incidence of benign tumors of the salivary glands will most likely continue to elude us. […] The true incidence of benign salivary gland tumors is unknown, as no epidemiological registries for this tumor entity have been established anywhere in the world. […] The annual incidence of all salivary gland neoplasms is reported to be in the range of 0.4-13.5 cases per 100,000 population throughout the world, and it has been reported that 21.0%-36.8% of these are diagnosed as malignant.

• #6

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The majority (68%) of the SGT presented in major and 32% in the minor glands. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists. […] Fortunately, they are rare, with an annual estimated incidence of approximately 2.5-3.0 per 100,000 people in the Western world. […] Most SGT are benign with ~70% arising in major glands and ~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers with 15-35% of parotid gland, 41-45% of submandibular and 70-90% of sublingual glands tumour being malignant.

• #7 Parotid Tumor Medical Statistics, Parotid Tumor Benign, Parotid Cancer

  https://parotidpatientproject.org/parotid-education/medical-statistics.html

  Salivary gland tumors comprise approximately 6% of all head and neck tumors. […] Approximately 6 people per 100,000 are diagnosed with a parotid tumor. […] Approximately, 20,000 new cases of parotid tumors are diagnosed per year in the United States. […] Parotid tumors occur in all ages, races, and sexes. […] 80% of salivary gland tumors are located in the parotid gland. […] 80% of parotid tumors are benign; 20% are malignant. […] Parotid tumors account for 1% of malignancies in children. […] 75% percent of parotid tumors are benign; 25% are malignant. […] Glandular parotid tumors, which are more common in adults, have a 50% chance of being malignant in children.

• #8 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Most salivary gland tumors are benign. […] Salivary gland tumors account for about 5% of all neoplasms of the head and neck. Most (75%) occur in the parotid glands, which are the largest among the three sets of major salivary glands. […] Only about 20% of parotid gland tumors are malignant. […] The five-year relative survival rate for salivary gland cancer depends on the stage the cancer. From Stage I to IV, the rates are 96%, 77%, 73%, and 37%, respectively. […] Although most parotid gland tumors grow slowly and are noncancerous, they might continue to grow and can eventually become cancerous. […] Surgery with the complete removal the parotid gland (parotidectomy) and of the tumor, including a cuff of histologically normal tissue for adequate margins, is the mainstay treatment for parotid gland tumors.

• #9 Parotid Tumor Medical Statistics, Parotid Tumor Benign, Parotid Cancer

  https://parotidpatientproject.org/parotid-education/medical-statistics.html

  Salivary gland tumors comprise approximately 6% of all head and neck tumors. […] Approximately 6 people per 100,000 are diagnosed with a parotid tumor. […] Approximately, 20,000 new cases of parotid tumors are diagnosed per year in the United States. […] Parotid tumors occur in all ages, races, and sexes. […] 80% of salivary gland tumors are located in the parotid gland. […] 80% of parotid tumors are benign; 20% are malignant. […] Parotid tumors account for 1% of malignancies in children. […] 75% percent of parotid tumors are benign; 25% are malignant. […] Glandular parotid tumors, which are more common in adults, have a 50% chance of being malignant in children.

• #10 Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis

  https://www.mdpi.com/2077-0383/10/8/1663

  Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. […] The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. […] The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors. […] The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. […] This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. […] Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.

• #11 Parotid Tumor Medical Statistics, Parotid Tumor Benign, Parotid Cancer

  https://parotidpatientproject.org/parotid-education/medical-statistics.html

  Salivary gland tumors comprise approximately 6% of all head and neck tumors. […] Approximately 6 people per 100,000 are diagnosed with a parotid tumor. […] Approximately, 20,000 new cases of parotid tumors are diagnosed per year in the United States. […] Parotid tumors occur in all ages, races, and sexes. […] 80% of salivary gland tumors are located in the parotid gland. […] 80% of parotid tumors are benign; 20% are malignant. […] Parotid tumors account for 1% of malignancies in children. […] 75% percent of parotid tumors are benign; 25% are malignant. […] Glandular parotid tumors, which are more common in adults, have a 50% chance of being malignant in children.

• #12 Salivary Gland Tumors – Ear, Nose, and Throat Disorders – MSD Manual Professional Edition

  https://www.msdmanuals.com/professional/ear-nose-and-throat-disorders/tumors-of-the-head-and-neck/salivary-gland-tumors

  Most salivary gland tumors are benign and occur in the parotid glands. […] About 85% of salivary gland tumors occur in the parotid glands, followed by the submandibular and minor salivary glands, and about 1% occur in the sublingual glands. […] Only about 20 to 25% of salivary gland tumors are malignant; the parotid gland is most commonly affected. […] Cancers are firm, nodular, and can be fixed to adjacent tissue; pain and nerve involvement (causing numbness and/or weakness) are common. […] Perform biopsy and CT and MRI if cancer is confirmed. […] Treat using surgery, sometimes plus radiation therapy for certain cancers.

• #13 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Most salivary gland tumors are benign. […] Salivary gland tumors account for about 5% of all neoplasms of the head and neck. Most (75%) occur in the parotid glands, which are the largest among the three sets of major salivary glands. […] Only about 20% of parotid gland tumors are malignant. […] The five-year relative survival rate for salivary gland cancer depends on the stage the cancer. From Stage I to IV, the rates are 96%, 77%, 73%, and 37%, respectively. […] Although most parotid gland tumors grow slowly and are noncancerous, they might continue to grow and can eventually become cancerous. […] Surgery with the complete removal the parotid gland (parotidectomy) and of the tumor, including a cuff of histologically normal tissue for adequate margins, is the mainstay treatment for parotid gland tumors.

• #14

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #15

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The aim of this multicentre international study was to analyse SGT data from numerous tertiary hospitals across the world with a view to obtaining up to date frequency and distribution of SGT. […] The total number of SGT was 5,739. […] Of these, 65% were benign tumours, and 35% were malignant. […] Overall, the parotid gland was the most common location for SGTs accounting for 59% followed by minor (32%) and submandibular (8%) salivary glands. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] Salivary gland tumours are rare, but show a gradual increasing incidence over the last decade and a half. […] We report the largest multicentre investigation of SGT to date showing that the majority are benign (65%), with a slight predilection for females (54%).

• #16 Epidemiology of salivary gland tumours (Doctor Faris Alabeedi MSc, MMedSc, PgDip, BDS.) | PPT

  https://www.slideshare.net/slideshow/epidemiology-of-salivary-gland-tumours/124146795

  6) Most tumour in the: 1- Parotid = benign 2- Lips = are in the upper lip and benign 3- Submandibular = 50% benign + 50% malignant 4- Sublingual = malignant 5- tongue = Malignant. […] 7) Major salivary gland tumours Malignant tumours comprise 15-32% of parotid tumours, 41-45% of submandibular tumours and 70-90% of sublingual tumours. […] 8) About one half of the tumours that arise in these glands are malignant. […] 9) The incidence of malignancy depends on the site of occurrence. […] 10) The findings indicate that benign neoplasia were more common than malignant ones, while pleomorphic adenoma was the most frequent type. […] 11) Concerning patients gender, women were more frequently affected. […] 12) Peak incidence relative to age was respectively the third and seventh decades for benign and malignant neoplasia. […] 13) Remember the rule of nines! Nine out of ten tumours affect the parotid. […] 14) Nine out of ten tumours are benign. […] 15) Nine out of ten tumours are PSAs.

• #17 Salivary gland tumors: Treatment of locoregional disease – UpToDate

  https://www.uptodate.com/contents/salivary-gland-tumors-treatment-of-locoregional-disease

  Salivary gland tumors include a wide range of tumor types, which can be either benign or malignant (table 1). Approximately 85 percent arise in the parotid; the remainder originate in the submandibular, sublingual, and minor salivary glands, which are located throughout the submucosa of the mouth and upper aerodigestive tract (figure 1) [1]. Approximately 25 percent of parotid tumors are malignant, compared with 40 to 45 percent of submandibular gland tumors, 70 to 90 percent of sublingual gland tumors, and 50 to 75 percent of minor salivary gland tumors. […] Treatment recommendations are based upon retrospective reviews of clinical experience, and there are almost no data from randomized trials to guide treatment decisions. The published literature predominately focuses on the parotid gland, reflecting the relative frequency of parotid gland tumors compared with tumors at other sites. The treatment of locoregional disease, which includes stages I through IVB (table 2A-B), will be discussed here.

• #18 Parotid Tumor Medical Statistics, Parotid Tumor Benign, Parotid Cancer

  https://parotidpatientproject.org/parotid-education/medical-statistics.html

  Salivary gland tumors comprise approximately 6% of all head and neck tumors. […] Approximately 6 people per 100,000 are diagnosed with a parotid tumor. […] Approximately, 20,000 new cases of parotid tumors are diagnosed per year in the United States. […] Parotid tumors occur in all ages, races, and sexes. […] 80% of salivary gland tumors are located in the parotid gland. […] 80% of parotid tumors are benign; 20% are malignant. […] Parotid tumors account for 1% of malignancies in children. […] 75% percent of parotid tumors are benign; 25% are malignant. […] Glandular parotid tumors, which are more common in adults, have a 50% chance of being malignant in children.

• #19 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists.

• #20

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #21

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Approximately 69% of SGT occur in patients between the fourth to seventh decade of life with a significant difference between the average age for benign and malignant tumours. […] The majority of SGT presented in the major glands (68%), with the parotid gland being the most common location (70%) for benign and minor glands (47%) for malignant tumours.

• #22 Salivary Gland Neoplasms: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/852373-overview

  Salivary gland neoplasms make up 6% of all head and neck tumors. The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. Mortality from malignant salivary gland neoplasms varies by stage and pathology, but the overall 5-year survival rate is 72%. […] Salivary gland neoplasms most commonly appear in the sixth decade of life. Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. […] Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. […] Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands.

• #23 Epidemiological and clinical characteristics of 407 sa…

  https://otolaryngologypl.com/seo/article/01.3001.0015.9816/en

  Among patients with malignant tumors, those aged above 60 constituted more than 50% of the total number of patients treated for salivary gland tumors. […] The average age of patients at the diagnosis of salivary gland malignancy was 60.1 years. […] Malignant tumors accounted for 17.4% of all salivary gland tumors. The most common types of malignancies included adenoid cystic carcinoma (28.2%), mucoepidermoid carcinoma (12.7%), and acinic cell carcinoma (9.9%). […] Salivary gland tumors were most commonly detected within the parotid glands (92%). […] The risk of malignancy was higher in tumors located within the submandibular gland (42% of all tumors in that location) than in the tumors located within the parotid glands (15% of all tumors in that location).

• #24 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists.

• #25

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #26

  https://www.ijmedicine.com/index.php/ijam/article/view/581

  Salivary gland tumors constitute a highly heterogeneous histopathologic group. […] There are few epidemiological studies of large series of benign and malignant epithelial tumors of major salivary glands in South India. […] Patients with benign and malignant tumors presented with a mean age of 52.3 and 55.9 years respectively. […] The frequency of benign tumors was 80.6% (n = 145) and of malignant tumors was 19.4% (n = 35). […] There was a higher prevalence of tumors in males 60.6% (n = 109) than in females 39.4% (n = 71). […] 91.9% (n = 164) of the tumors were localized in the parotid gland, 8.3% (n = 15) in the submandibular gland and 0.6% (n = 1) in the sublingual gland. […] Parotid gland was the most common site of both benign and malignant tumours.

• #27

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The majority (68%) of the SGT presented in major and 32% in the minor glands. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists. […] Fortunately, they are rare, with an annual estimated incidence of approximately 2.5-3.0 per 100,000 people in the Western world. […] Most SGT are benign with ~70% arising in major glands and ~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers with 15-35% of parotid gland, 41-45% of submandibular and 70-90% of sublingual glands tumour being malignant.

• #28 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Most SGT are benign with~70% arising in major glands and~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers. […] The majority of the SGT involved the major glands 68% (n=3,910) with 32% (n=1,829) involving the minor glands. […] Overall, the parotid gland was the most common location for SGTs accounting for (59%) followed by minor (32%) and submandibular (8%) salivary glands similar to older and similarly large SGT demographical studies. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] It would also be useful to establish international datasets of these tumours for use by other researchers (whole slide image or research repositories) including histological reassessment and classification according to the most recent WHO criteria.

• #29

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The majority (68%) of the SGT presented in major and 32% in the minor glands. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists. […] Fortunately, they are rare, with an annual estimated incidence of approximately 2.5-3.0 per 100,000 people in the Western world. […] Most SGT are benign with ~70% arising in major glands and ~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers with 15-35% of parotid gland, 41-45% of submandibular and 70-90% of sublingual glands tumour being malignant.

• #30

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The aim of this multicentre international study was to analyse SGT data from numerous tertiary hospitals across the world with a view to obtaining up to date frequency and distribution of SGT. […] The total number of SGT was 5,739. […] Of these, 65% were benign tumours, and 35% were malignant. […] Overall, the parotid gland was the most common location for SGTs accounting for 59% followed by minor (32%) and submandibular (8%) salivary glands. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] Salivary gland tumours are rare, but show a gradual increasing incidence over the last decade and a half. […] We report the largest multicentre investigation of SGT to date showing that the majority are benign (65%), with a slight predilection for females (54%).

• #31

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The majority (68%) of the SGT presented in major and 32% in the minor glands. […] The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. […] This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. […] Salivary gland tumours (SGT) are a heterogeneous group of neoplasms with a wide range of histological subtypes making diagnosis challenging for pathologists. […] Fortunately, they are rare, with an annual estimated incidence of approximately 2.5-3.0 per 100,000 people in the Western world. […] Most SGT are benign with ~70% arising in major glands and ~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers with 15-35% of parotid gland, 41-45% of submandibular and 70-90% of sublingual glands tumour being malignant.

• #32

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Approximately 69% of SGT occur in patients between the fourth to seventh decade of life with a significant difference between the average age for benign and malignant tumours. […] The majority of SGT presented in the major glands (68%), with the parotid gland being the most common location (70%) for benign and minor glands (47%) for malignant tumours.

• #33 Epidemiology of salivary gland tumours (Doctor Faris Alabeedi MSc, MMedSc, PgDip, BDS.) | PPT

  https://www.slideshare.net/slideshow/epidemiology-of-salivary-gland-tumours/124146795

  1) The most common salivary gland tumor is the pleomorphic adenoma, which comprises about half of all tumors and 65% of parotid gland tumors. […] 2) The most frequent malignant salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all tumors and 35% of malignant tumors. […] 3) Benign tumors are more common than malignant tumors, and the majority (about 70%) of salivary gland tumors occur in the parotid gland. […] 4) Relevant series published in literature showed that: salivary neoplasms, either benign or malignant, are usually present in greater salivary glands, specially the parotid (64-80%). […] 5) The parotid gland: Is the single most common site for any salivary neoplasm, with about 70% of all tumours arising at this site of which about 85% are benign.

• #34 SciELO Brazil – Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

  https://www.scielo.br/j/rhc/a/KpMbZ7SFmkjCcgLYCWHGTrL/

  Pleomorphic adenoma was the most common tumor (67.7%) of all salivary glands in the present study and corresponded to 84.8% of all benign tumors. […] The parotid gland is the main site affected by pleomorphic adenomas followed by the submandibular and minor salivary glands. […] The frequency observed in the literature of Warthin’s tumor ranged from 9% to 28%. […] Mucoepidermoid carcinomas (MEC) were more common in major salivary glands (8% of salivary gland tumors) than in minor salivary glands (2.4%). When we evaluated only malignant tumors, MEC was the most common tumor (52%). […] Adenoid cystic carcinoma (ACC) occurred in 5 cases of the total sample, 4 cases (16% of malignant salivary gland tumors) in the submandibular gland, and 1 case in a minor salivary gland (4%). […] Carcinoma ex pleomorphic adenoma formed 12% of malignant salivary gland tumors and affected only the parotid gland in our study population.

• #35 The role of immune surveillance in malignant transformation of benign salivary gland tumors | Oncotarget

  https://www.oncotarget.com/article/27900/text/

  Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). […] We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. […] Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior. […] In conclusion, adaptive immune surveillance may constrain the evolution of pleomorphic adenomas to malignancy. CA ex PA tumors have immunologically cold microenvironments compared with their de novo counterparts which may, in part, explain their more aggressive clinical behavior.

• #36 Warthin tumor | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/warthin-tumour?lang=us

  Warthin tumors are the 2nd most common benign parotid gland tumor (after pleomorphic adenoma) and represent up to 10% of all parotid tumors. […] They are the most common bilateral or multifocal benign parotid tumors. […] They typically occur in older age (6th decade) and are twice as common in men (2.2:1).

• #37 SciELO Brazil – Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

  https://www.scielo.br/j/rhc/a/KpMbZ7SFmkjCcgLYCWHGTrL/

  Pleomorphic adenoma was the most common tumor (67.7%) of all salivary glands in the present study and corresponded to 84.8% of all benign tumors. […] The parotid gland is the main site affected by pleomorphic adenomas followed by the submandibular and minor salivary glands. […] The frequency observed in the literature of Warthin’s tumor ranged from 9% to 28%. […] Mucoepidermoid carcinomas (MEC) were more common in major salivary glands (8% of salivary gland tumors) than in minor salivary glands (2.4%). When we evaluated only malignant tumors, MEC was the most common tumor (52%). […] Adenoid cystic carcinoma (ACC) occurred in 5 cases of the total sample, 4 cases (16% of malignant salivary gland tumors) in the submandibular gland, and 1 case in a minor salivary gland (4%). […] Carcinoma ex pleomorphic adenoma formed 12% of malignant salivary gland tumors and affected only the parotid gland in our study population.

• #38 Warthin tumor | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/warthin-tumour?lang=us

  Warthin tumors are the 2nd most common benign parotid gland tumor (after pleomorphic adenoma) and represent up to 10% of all parotid tumors. […] They are the most common bilateral or multifocal benign parotid tumors. […] They typically occur in older age (6th decade) and are twice as common in men (2.2:1).

• #39 Epidemiology of salivary gland tumours (Doctor Faris Alabeedi MSc, MMedSc, PgDip, BDS.) | PPT

  https://www.slideshare.net/slideshow/epidemiology-of-salivary-gland-tumours/124146795

  1) The most common salivary gland tumor is the pleomorphic adenoma, which comprises about half of all tumors and 65% of parotid gland tumors. […] 2) The most frequent malignant salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all tumors and 35% of malignant tumors. […] 3) Benign tumors are more common than malignant tumors, and the majority (about 70%) of salivary gland tumors occur in the parotid gland. […] 4) Relevant series published in literature showed that: salivary neoplasms, either benign or malignant, are usually present in greater salivary glands, specially the parotid (64-80%). […] 5) The parotid gland: Is the single most common site for any salivary neoplasm, with about 70% of all tumours arising at this site of which about 85% are benign.

• #40 SciELO Brazil – Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

  https://www.scielo.br/j/rhc/a/KpMbZ7SFmkjCcgLYCWHGTrL/

  Pleomorphic adenoma was the most common tumor (67.7%) of all salivary glands in the present study and corresponded to 84.8% of all benign tumors. […] The parotid gland is the main site affected by pleomorphic adenomas followed by the submandibular and minor salivary glands. […] The frequency observed in the literature of Warthin’s tumor ranged from 9% to 28%. […] Mucoepidermoid carcinomas (MEC) were more common in major salivary glands (8% of salivary gland tumors) than in minor salivary glands (2.4%). When we evaluated only malignant tumors, MEC was the most common tumor (52%). […] Adenoid cystic carcinoma (ACC) occurred in 5 cases of the total sample, 4 cases (16% of malignant salivary gland tumors) in the submandibular gland, and 1 case in a minor salivary gland (4%). […] Carcinoma ex pleomorphic adenoma formed 12% of malignant salivary gland tumors and affected only the parotid gland in our study population.

• #41 SciELO Brazil – Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

  https://www.scielo.br/j/rhc/a/KpMbZ7SFmkjCcgLYCWHGTrL/

  Pleomorphic adenoma was the most common tumor (67.7%) of all salivary glands in the present study and corresponded to 84.8% of all benign tumors. […] The parotid gland is the main site affected by pleomorphic adenomas followed by the submandibular and minor salivary glands. […] The frequency observed in the literature of Warthin’s tumor ranged from 9% to 28%. […] Mucoepidermoid carcinomas (MEC) were more common in major salivary glands (8% of salivary gland tumors) than in minor salivary glands (2.4%). When we evaluated only malignant tumors, MEC was the most common tumor (52%). […] Adenoid cystic carcinoma (ACC) occurred in 5 cases of the total sample, 4 cases (16% of malignant salivary gland tumors) in the submandibular gland, and 1 case in a minor salivary gland (4%). […] Carcinoma ex pleomorphic adenoma formed 12% of malignant salivary gland tumors and affected only the parotid gland in our study population.

• #42 What Is Salivary Gland Cancer? | Types of Salivary Gland Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/about/what-is-salivary-gland-cancer.html

  Salivary gland cancer starts in one of the salivary glands. Compared to other types of head and neck cancers, salivary gland cancers are rare. Most salivary gland tumors start here. Most of these tumors are benign (not cancer), but the parotid glands are still where most malignant (cancer) salivary gland tumors start. […] Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Most start in the parotid glands. […] Adenoid cystic carcinoma is the second most common type of salivary gland cancer. […] Most acinic cell carcinomas start in the parotid gland. […] These tumors tend to start in the minor salivary glands. […] When seen in the lab, these cancers have enough features to show that they are adenocarcinomas, but not enough detail to classify them further. They are most commonly found in the parotid glands and the minor salivary glands.

• #43 Salivary gland tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/symptoms-causes/syc-20354151

  Salivary gland tumors are rare. […] Most salivary gland tumors occur in the parotid gland. Of these, most aren’t cancer. For every five parotid gland tumors, on average, only one is found to be cancerous. […] The cause of many salivary gland tumors isn’t known. Healthcare professionals have identified some things that raise the risk of salivary gland tumors. These include smoking and radiation therapy for cancer. […] Factors that may increase the risk of salivary gland tumors include older age, radiation exposure, smoking tobacco, viral infections, and workplace exposure to certain substances.

• #44 Parotid tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parotid-tumor/symptoms-causes/syc-20578986

  Parotid tumors are growths of cells that start in the parotid glands. […] The parotid glands are the most common place that salivary gland tumors happen. […] Most parotid tumors aren’t cancerous. These are called noncancerous or benign parotid tumors. Sometimes the tumors are cancers. These are called malignant parotid tumors or parotid gland cancers. […] Diagnosis and treatment for parotid tumors is often done by doctors who specialize in problems that affect the ear, nose and throat. […] Factors that increase the risk of parotid tumors include increasing age. Parotid tumors can happen at any age. However, they are more common in older adults. […] Previous radiation therapy treatments. People who have had radiation therapy to the head and neck area in the past are at a higher risk of parotid tumors. […] Exposure to harmful substances. People who work with certain substances may have an increased risk of salivary gland tumors, including parotid tumors.

• #45 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #46 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. […] Compared to other cancers, salivary gland malignancies are relatively rare in the United States. In 2008, they comprised only about 12% of oral pharyngeal cancers or 0 3% of cancers at all sites combined. […] During the 2000-2008 period, salivary gland malignancies occurred more often in men at an average annual incidence rate of 1 41 cases per 100,000 males than in women at 1 00. […] Through the past few years, its incidence has also slowly increased among men at about 1 2% per year. […] Although it is possible for salivary gland cancer to occur in people of all ages, 2 out of 3 cancers are found in people 55 and older. […] On average, people are diagnosed at age of 64.

• #47

  https://journals.lww.com/epidem/fulltext/2012/09000/incidence_trends_of_malignant_parotid_gland_tumors.21.aspx

  Salivary gland tumors are relatively rare, accounting for 25% of all head and neck tumors in various countries, with the most common subtype (75%) being parotid gland tumors. Ionizing radiation exposure is the only established risk factor to date. Recent studies have reported an increased incidence of malignant parotid gland tumors during the last decades, especially in Israel, but also in England. This has been speculated to reflect the increased prevalence of mobile phone use since the 1990s, from virtually 0 to close to 100%, considering the high exposure of parotid gland during mobile phone use. […] In Sweden, 3604 salivary gland tumor cases in adults 20 years or older were identified during the period 1970-2009, of whom 2624 (73%) were malignant neoplasms of the parotid gland. The incidence of parotid gland tumors in Sweden decreased slightly during the early study period, and then remained stable for both sexes. The age-standardized rate of salivary gland tumors in the whole Nordic population during the period 1970-2009 was 1.1/100,000 for men and 0.9/100,000 for women. No increase in incidence was observed; the annual percent change was 0.1% for men and 0.2% for women.

• #48 Parotid tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parotid-tumor/symptoms-causes/syc-20578986

  Parotid tumors are growths of cells that start in the parotid glands. […] The parotid glands are the most common place that salivary gland tumors happen. […] Most parotid tumors aren’t cancerous. These are called noncancerous or benign parotid tumors. Sometimes the tumors are cancers. These are called malignant parotid tumors or parotid gland cancers. […] Diagnosis and treatment for parotid tumors is often done by doctors who specialize in problems that affect the ear, nose and throat. […] Factors that increase the risk of parotid tumors include increasing age. Parotid tumors can happen at any age. However, they are more common in older adults. […] Previous radiation therapy treatments. People who have had radiation therapy to the head and neck area in the past are at a higher risk of parotid tumors. […] Exposure to harmful substances. People who work with certain substances may have an increased risk of salivary gland tumors, including parotid tumors.

• #49 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #50 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #51 Parotid tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parotid-tumor/symptoms-causes/syc-20578986

  Parotid tumors are growths of cells that start in the parotid glands. […] The parotid glands are the most common place that salivary gland tumors happen. […] Most parotid tumors aren’t cancerous. These are called noncancerous or benign parotid tumors. Sometimes the tumors are cancers. These are called malignant parotid tumors or parotid gland cancers. […] Diagnosis and treatment for parotid tumors is often done by doctors who specialize in problems that affect the ear, nose and throat. […] Factors that increase the risk of parotid tumors include increasing age. Parotid tumors can happen at any age. However, they are more common in older adults. […] Previous radiation therapy treatments. People who have had radiation therapy to the head and neck area in the past are at a higher risk of parotid tumors. […] Exposure to harmful substances. People who work with certain substances may have an increased risk of salivary gland tumors, including parotid tumors.

• #52 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #53 May 2016 | Case of the Month Question for Residency Program | UC Davis Department of Pathology

  https://health.ucdavis.edu/pathology/education/residency_program/caseofthemonth/201605/final.html

  Salivary gland tumors are uncommon, comprising 2000-2500 cases in the United States each year. […] About 25% of parotid gland tumors are malignant, the most frequent of which is mucoepidermoid carcinoma, followed by adenoid cystic carcinoma. […] Risk factors for this cancer are not well-established. However some studies have demonstrated that it may be caused by human cytomegalovirus (CMV), a highly prevalent and usually asymptomatic infection that has tropism for salivary glands.

• #54 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #55 Epidemiological and clinical characteristics of 407 sa…

  https://otolaryngologypl.com/seo/article/01.3001.0015.9816/en

  Tumors of the salivary glands account for approximately 3 to 4% of all head and neck neoplasms. It is estimated that 10–15% of them are malignant. […] The identified risk factors for tumors of the salivary glands are: ultraviolet radiation, ionizing radiation, viral infections, nicotine and alcohol. […] The material contained 407 neoplasms of the salivary glands over a 11-year period, of which malignant neoplasms accounted for 17.4%. […] Tumors of the salivary gland the most often affected the parotid gland (92%). […] According to the literature, about 9–20% of all primary epithelial tumors develop in minor salivary glands, and 50% of these are malignant tumors. […] The percentage of malignant tumors increases with patients’ age, regardless of their location. […] It should also be noted that the peak incidence of benign tumors within the study material was usually observed between the 5th and 6th decade of life, with an evident drop in the prevalence after that age.

• #56 What Are the Risk Factors for Salivary Gland Cancer? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/causes-risks-prevention/risk-factors.html

  A few risk factors are known to make a person more likely to develop salivary gland cancer, but most salivary gland cancers start without any clear cause. […] The risk of salivary gland cancer goes up as people get older. […] Radiation treatment to the head and neck area for other medical reasons increases your risk of salivary gland cancer, especially if your salivary glands were not protected during the radiation. […] Some studies have suggested that people who work with certain metals (nickel alloy dust) or minerals (silica dust), and people who work in asbestos mining, plumbing, rubber products manufacturing, and some types of woodworking may be at increased risk for salivary gland cancer, but these links are not certain. […] Some viral infections might be associated with certain salivary gland tumors. […] People with human immunodeficiency virus (HIV) are also at risk for salivary gland cancers. […] One study has suggested an increased risk of parotid gland tumors among heavy cell phone users.

• #57

  https://journals.lww.com/epidem/fulltext/2012/09000/incidence_trends_of_malignant_parotid_gland_tumors.21.aspx

  Previous reports of an increased incidence of parotid gland tumors possibly due to exposure to mobile phone use were not supported by our results. We found a stable or declining trend in the incidence of salivary gland tumors during the last 40 years, during which there was relatively early and full adaptation of mobile phone use in Nordic countries. However, none of these incidence-trend studies had information on individual mobile phone use and therefore cannot directly link mobile phone use to parotid gland tumor risk. Data from case-control studies with individual self-reported information on mobile phone use do not generally support the hypothesis that mobile phone use increases parotid gland tumor risk. […] If mobile phone use were a noticeable risk factor for parotid gland tumors, some increase would have been seen in the Nordic countries unless the latency period exceeds 15-20 years. Our results suggest other explanations for increases in the registered incidence of parotid gland tumors observed in Israel and United Kingdom.

• #58 Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis

  https://www.mdpi.com/2077-0383/10/8/1663

  Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. […] The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. […] The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors. […] The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. […] This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. […] Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.

• #59

  https://journals.lww.com/10.1097/EDE.0b013e3181feb9f0

  Comparing the parotid gland tumors with all other salivary gland locations, there were no important differences in risk by sex, age, or ethnicity. […] Trends for parotid gland cancers have seldom been reported, and have not been compared with other types of salivary gland tumors. […] The total number of parotid gland cancers in Israel increased 4-fold from 1970 to 2006 (from 16 to 64 cases per year), whereas other major salivary gland cancers remained stable. […] The steepest increase occurred after 2001, with an average of 37 cases of parotid gland cancer annually before that date and 61 cases per year subsequently. […] The distribution of cases by age, sex, or tumor type did not change substantially during this time. […] The population of Israel increased 2.1-fold from 1970 to 2001, but only 1.1-fold from 2001 to 2006.

• #60

  https://journals.lww.com/10.1097/EDE.0b013e3181feb9f0

  Comparing the parotid gland tumors with all other salivary gland locations, there were no important differences in risk by sex, age, or ethnicity. […] Trends for parotid gland cancers have seldom been reported, and have not been compared with other types of salivary gland tumors. […] The total number of parotid gland cancers in Israel increased 4-fold from 1970 to 2006 (from 16 to 64 cases per year), whereas other major salivary gland cancers remained stable. […] The steepest increase occurred after 2001, with an average of 37 cases of parotid gland cancer annually before that date and 61 cases per year subsequently. […] The distribution of cases by age, sex, or tumor type did not change substantially during this time. […] The population of Israel increased 2.1-fold from 1970 to 2001, but only 1.1-fold from 2001 to 2006.

• #61

  https://journals.lww.com/10.1097/EDE.0b013e3181feb9f0

  Comparing the parotid gland tumors with all other salivary gland locations, there were no important differences in risk by sex, age, or ethnicity. […] Trends for parotid gland cancers have seldom been reported, and have not been compared with other types of salivary gland tumors. […] The total number of parotid gland cancers in Israel increased 4-fold from 1970 to 2006 (from 16 to 64 cases per year), whereas other major salivary gland cancers remained stable. […] The steepest increase occurred after 2001, with an average of 37 cases of parotid gland cancer annually before that date and 61 cases per year subsequently. […] The distribution of cases by age, sex, or tumor type did not change substantially during this time. […] The population of Israel increased 2.1-fold from 1970 to 2001, but only 1.1-fold from 2001 to 2006.

• #62

  https://journals.lww.com/epidem/fulltext/2012/09000/incidence_trends_of_malignant_parotid_gland_tumors.21.aspx

  Salivary gland tumors are relatively rare, accounting for 25% of all head and neck tumors in various countries, with the most common subtype (75%) being parotid gland tumors. Ionizing radiation exposure is the only established risk factor to date. Recent studies have reported an increased incidence of malignant parotid gland tumors during the last decades, especially in Israel, but also in England. This has been speculated to reflect the increased prevalence of mobile phone use since the 1990s, from virtually 0 to close to 100%, considering the high exposure of parotid gland during mobile phone use. […] In Sweden, 3604 salivary gland tumor cases in adults 20 years or older were identified during the period 1970-2009, of whom 2624 (73%) were malignant neoplasms of the parotid gland. The incidence of parotid gland tumors in Sweden decreased slightly during the early study period, and then remained stable for both sexes. The age-standardized rate of salivary gland tumors in the whole Nordic population during the period 1970-2009 was 1.1/100,000 for men and 0.9/100,000 for women. No increase in incidence was observed; the annual percent change was 0.1% for men and 0.2% for women.

• #63

  https://journals.lww.com/epidem/fulltext/2012/09000/incidence_trends_of_malignant_parotid_gland_tumors.21.aspx

  Previous reports of an increased incidence of parotid gland tumors possibly due to exposure to mobile phone use were not supported by our results. We found a stable or declining trend in the incidence of salivary gland tumors during the last 40 years, during which there was relatively early and full adaptation of mobile phone use in Nordic countries. However, none of these incidence-trend studies had information on individual mobile phone use and therefore cannot directly link mobile phone use to parotid gland tumor risk. Data from case-control studies with individual self-reported information on mobile phone use do not generally support the hypothesis that mobile phone use increases parotid gland tumor risk. […] If mobile phone use were a noticeable risk factor for parotid gland tumors, some increase would have been seen in the Nordic countries unless the latency period exceeds 15-20 years. Our results suggest other explanations for increases in the registered incidence of parotid gland tumors observed in Israel and United Kingdom.

• #64

  https://journals.lww.com/epidem/fulltext/2012/09000/incidence_trends_of_malignant_parotid_gland_tumors.21.aspx

  Salivary gland tumors are relatively rare, accounting for 25% of all head and neck tumors in various countries, with the most common subtype (75%) being parotid gland tumors. Ionizing radiation exposure is the only established risk factor to date. Recent studies have reported an increased incidence of malignant parotid gland tumors during the last decades, especially in Israel, but also in England. This has been speculated to reflect the increased prevalence of mobile phone use since the 1990s, from virtually 0 to close to 100%, considering the high exposure of parotid gland during mobile phone use. […] In Sweden, 3604 salivary gland tumor cases in adults 20 years or older were identified during the period 1970-2009, of whom 2624 (73%) were malignant neoplasms of the parotid gland. The incidence of parotid gland tumors in Sweden decreased slightly during the early study period, and then remained stable for both sexes. The age-standardized rate of salivary gland tumors in the whole Nordic population during the period 1970-2009 was 1.1/100,000 for men and 0.9/100,000 for women. No increase in incidence was observed; the annual percent change was 0.1% for men and 0.2% for women.

• #65 Increase in the incidence of parotid gland tumors in t…

  https://otolaryngologypl.com/seo/article/01.3001.0009.8412/en

  Increase in the incidence of parotid gland tumors in the years 2005–2014 […] The aim of the study was to assess whether there is an upward trend in cancer incidence within the parotid glands, with particular emphasis on cancers. […] A significant increase in the incidence of benign tumours, especially mixed and Warthin tumours, was demonstrated. There was no significant increase in the number of malignant tumours over the analysed period of time. […] The present study recorded and confirmed statistically an overall increase in the incidence of parotid gland tumours over the analysed years. […] An increase in the number of removed cancers failed to prove unequivocally a statistically significant rise in the number of malignant parotid gland tumours. […] The data do not permit to conclude that there is a statistically significant upward trend in the incidence of malignant parotid gland tumours over the analysed period of time.

• #66 Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis

  https://www.mdpi.com/2077-0383/10/8/1663

  Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. […] The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. […] The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors. […] The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. […] This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. […] Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.

• #67

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The aim of this multicentre international study was to analyse SGT data from numerous tertiary hospitals across the world with a view to obtaining up to date frequency and distribution of SGT. […] The total number of SGT was 5,739. […] Of these, 65% were benign tumours, and 35% were malignant. […] Overall, the parotid gland was the most common location for SGTs accounting for 59% followed by minor (32%) and submandibular (8%) salivary glands. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] Salivary gland tumours are rare, but show a gradual increasing incidence over the last decade and a half. […] We report the largest multicentre investigation of SGT to date showing that the majority are benign (65%), with a slight predilection for females (54%).

• #68 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. […] Compared to other cancers, salivary gland malignancies are relatively rare in the United States. In 2008, they comprised only about 12% of oral pharyngeal cancers or 0 3% of cancers at all sites combined. […] During the 2000-2008 period, salivary gland malignancies occurred more often in men at an average annual incidence rate of 1 41 cases per 100,000 males than in women at 1 00. […] Through the past few years, its incidence has also slowly increased among men at about 1 2% per year. […] Although it is possible for salivary gland cancer to occur in people of all ages, 2 out of 3 cancers are found in people 55 and older. […] On average, people are diagnosed at age of 64.

• #69 Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis

  https://www.mdpi.com/2077-0383/10/8/1663

  Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. […] The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. […] The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors. […] The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. […] This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. […] Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.

• #70

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #71 Epidemiology of Benign Salivary Gland Neoplasms | Pocket Dentistry

  https://pocketdentistry.com/epidemiology-of-benign-salivary-gland-neoplasms/

  Benign tumors of the salivary glands represent the majority of salivary gland diseases. […] Determining the true incidence of benign salivary gland tumors in populations is made difficult by the fact that there is no indication for establishing registries such as those available for malignant disease. […] The true incidence of benign tumors of the salivary glands will most likely continue to elude us. […] The true incidence of benign salivary gland tumors is unknown, as no epidemiological registries for this tumor entity have been established anywhere in the world. […] The annual incidence of all salivary gland neoplasms is reported to be in the range of 0.4-13.5 cases per 100,000 population throughout the world, and it has been reported that 21.0%-36.8% of these are diagnosed as malignant.

• #72 Epidemiology of Benign Salivary Gland Neoplasms | Pocket Dentistry

  https://pocketdentistry.com/epidemiology-of-benign-salivary-gland-neoplasms/

  Benign tumors of the salivary glands represent the majority of salivary gland diseases. […] Determining the true incidence of benign salivary gland tumors in populations is made difficult by the fact that there is no indication for establishing registries such as those available for malignant disease. […] The true incidence of benign tumors of the salivary glands will most likely continue to elude us. […] The true incidence of benign salivary gland tumors is unknown, as no epidemiological registries for this tumor entity have been established anywhere in the world. […] The annual incidence of all salivary gland neoplasms is reported to be in the range of 0.4-13.5 cases per 100,000 population throughout the world, and it has been reported that 21.0%-36.8% of these are diagnosed as malignant.

• #73 Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis

  https://www.mdpi.com/2077-0383/10/8/1663

  Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. […] The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. […] The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors. […] The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. […] This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. […] Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.

• #74

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. […] To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. […] This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. […] A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. […] A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed.

• #75 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Most SGT are benign with~70% arising in major glands and~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers. […] The majority of the SGT involved the major glands 68% (n=3,910) with 32% (n=1,829) involving the minor glands. […] Overall, the parotid gland was the most common location for SGTs accounting for (59%) followed by minor (32%) and submandibular (8%) salivary glands similar to older and similarly large SGT demographical studies. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] It would also be useful to establish international datasets of these tumours for use by other researchers (whole slide image or research repositories) including histological reassessment and classification according to the most recent WHO criteria.

• #76

  https://link.springer.com/article/10.1007/s12105-022-01459-0

  The aim of this multicentre international study was to analyse SGT data from numerous tertiary hospitals across the world with a view to obtaining up to date frequency and distribution of SGT. […] The total number of SGT was 5,739. […] Of these, 65% were benign tumours, and 35% were malignant. […] Overall, the parotid gland was the most common location for SGTs accounting for 59% followed by minor (32%) and submandibular (8%) salivary glands. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] Salivary gland tumours are rare, but show a gradual increasing incidence over the last decade and a half. […] We report the largest multicentre investigation of SGT to date showing that the majority are benign (65%), with a slight predilection for females (54%).

• #77 Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9729635/

  Most SGT are benign with~70% arising in major glands and~25% are from the minor glands. […] Malignant SGT comprise approximately 26% of all head and neck cancers. […] The majority of the SGT involved the major glands 68% (n=3,910) with 32% (n=1,829) involving the minor glands. […] Overall, the parotid gland was the most common location for SGTs accounting for (59%) followed by minor (32%) and submandibular (8%) salivary glands similar to older and similarly large SGT demographical studies. […] Understanding the epidemiological landscape and distribution of histological subtypes of salivary gland tumours is crucial for a better diagnosis of this diverse and complex group of tumours. […] It would also be useful to establish international datasets of these tumours for use by other researchers (whole slide image or research repositories) including histological reassessment and classification according to the most recent WHO criteria.

• #78 The role of immune surveillance in malignant transformation of benign salivary gland tumors | Oncotarget

  https://www.oncotarget.com/article/27900/text/

  Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). […] We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. […] Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior. […] In conclusion, adaptive immune surveillance may constrain the evolution of pleomorphic adenomas to malignancy. CA ex PA tumors have immunologically cold microenvironments compared with their de novo counterparts which may, in part, explain their more aggressive clinical behavior.

• #79 The role of immune surveillance in malignant transformation of benign salivary gland tumors | Oncotarget

  https://www.oncotarget.com/article/27900/

  Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). […] We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. […] Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior.

• #80 The role of immune surveillance in malignant transformation of benign salivary gland tumors | Oncotarget

  https://www.oncotarget.com/article/27900/text/

  Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). […] We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. […] Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior. […] In conclusion, adaptive immune surveillance may constrain the evolution of pleomorphic adenomas to malignancy. CA ex PA tumors have immunologically cold microenvironments compared with their de novo counterparts which may, in part, explain their more aggressive clinical behavior.

• #81 The role of immune surveillance in malignant transformation of benign salivary gland tumors | Oncotarget

  https://www.oncotarget.com/article/27900/

  Pleomorphic adenoma (PA), the most common salivary gland tumor, is a benign tumor that carries a risk of malignant transformation to various histologies of carcinoma ex pleomorphic adenoma (CA exPA). […] We found that increasing levels of immune infiltration and activation were associated with a generally lower probability of cancer developing ex-PA, suggesting that immune surveillance may constrain the malignant transformation of benign salivary tumors. […] Taken together, these data suggest a role for tumor escape from immune surveillance in the development of CA exPA. The immune-cold microenvironments of CA ex PA tumors may in part explain their more aggressive clinical behavior.

• #82 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Among the clinical N0 (with no regional lymph node metastasis) tumors, parotidectomy with complete excision of tumor with or without neck dissection for high-grade and high-stage tumors is suggested, while the clinical N+ (positive regional lymph node metastasis) require parotidectomy and neck dissection. […] One of the reported side effects of radiation as treatment for parotid gland cancer is hearing loss. […] Although parotid gland cancer is relatively rare, it still constitutes as a serious health hazard burdening our population because of its poor prognosis.

• #83 Parotid Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538340/

  Salivary glands are a common source of benign pathology; malignant tumors are rare. Approximately 300 cases per year of primary salivary gland malignancy are registered in the United Kingdom, of which fewer than ten occur in children. Patients with malignant lesions typically present in their sixth decade. The worldwide incidence is estimated at 0.5 to 3.0 per 100,000 per year, accounting for about 5% of all head and neck malignancies. The overall 5-year survival of malignant salivary disease depends on the stage of the disease but has been reported around 70%. […] The overall 5-year survival rate for salivary gland cancer is 72%.

• #84 Salivary Gland Neoplasms: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/852373-overview

  Salivary gland neoplasms make up 6% of all head and neck tumors. The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. Mortality from malignant salivary gland neoplasms varies by stage and pathology, but the overall 5-year survival rate is 72%. […] Salivary gland neoplasms most commonly appear in the sixth decade of life. Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. […] Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. […] Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands.

• #85 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Most salivary gland tumors are benign. […] Salivary gland tumors account for about 5% of all neoplasms of the head and neck. Most (75%) occur in the parotid glands, which are the largest among the three sets of major salivary glands. […] Only about 20% of parotid gland tumors are malignant. […] The five-year relative survival rate for salivary gland cancer depends on the stage the cancer. From Stage I to IV, the rates are 96%, 77%, 73%, and 37%, respectively. […] Although most parotid gland tumors grow slowly and are noncancerous, they might continue to grow and can eventually become cancerous. […] Surgery with the complete removal the parotid gland (parotidectomy) and of the tumor, including a cuff of histologically normal tissue for adequate margins, is the mainstay treatment for parotid gland tumors.

• #86 An overview of the rare parotid gland cancer | Head & Neck Oncology | Full Text

  https://headandneckoncology.biomedcentral.com/articles/10.1186/1758-3284-3-40

  Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. […] Compared to other cancers, salivary gland malignancies are relatively rare in the United States. In 2008, they comprised only about 12% of oral pharyngeal cancers or 0 3% of cancers at all sites combined. […] During the 2000-2008 period, salivary gland malignancies occurred more often in men at an average annual incidence rate of 1 41 cases per 100,000 males than in women at 1 00. […] Through the past few years, its incidence has also slowly increased among men at about 1 2% per year. […] Although it is possible for salivary gland cancer to occur in people of all ages, 2 out of 3 cancers are found in people 55 and older. […] On average, people are diagnosed at age of 64.

• #87 Salivary gland cancer — epidemiology | Kordzińska-Cisek | Nowotwory. Journal of Oncology

  https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/58955

  Salivary gland tumors represent 311% of all head and neck cancers and 0.2% of all neoplasms. Among Poles, malignancies involving the large salivary glands constituted 0.3% of all malignancies in Poland and 9.7% of head and neck neoplasms. In 2014, the morbidity rate was higher among women, but over the past 15 years there has been a slight prevalence among men. […] Salivary gland neoplasms are usually located in the parotid gland, then in the sub-mandibular gland. The best prognosis is for women whose cancers are located in the parotid gland and those with lobular carcinoma. Figures have been on the rise lately, however. Deaths have been on a stable level.

• #88 Salivary Gland Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq

  Most patients with benign tumors of the major or minor salivary glands present with painless swelling of the parotid, submandibular, or sublingual glands. Neurological signs, such as numbness or weakness caused by nerve involvement, typically indicate a malignancy. […] Approximately 10% to 15% of malignant parotid neoplasms present with pain. However, most parotid tumors, both benign and malignant, present as an asymptomatic mass in the gland. […] Early-stage, low-grade, malignant salivary gland tumors are usually curable by adequate surgical resection alone. The prognosis is more favorable when the tumor is in a major salivary gland. The parotid gland is most favorable followed by the submandibular gland. […] Overall, clinical stage, particularly tumor size, may be the crucial factor that determines the outcome of salivary gland cancer and may be more important than histological grade.

• #89 Epidemiological and clinical characteristics of 407 sa…

  https://otolaryngologypl.com/seo/article/01.3001.0015.9816/en

  Among patients with malignant tumors, those aged above 60 constituted more than 50% of the total number of patients treated for salivary gland tumors. […] The average age of patients at the diagnosis of salivary gland malignancy was 60.1 years. […] Malignant tumors accounted for 17.4% of all salivary gland tumors. The most common types of malignancies included adenoid cystic carcinoma (28.2%), mucoepidermoid carcinoma (12.7%), and acinic cell carcinoma (9.9%). […] Salivary gland tumors were most commonly detected within the parotid glands (92%). […] The risk of malignancy was higher in tumors located within the submandibular gland (42% of all tumors in that location) than in the tumors located within the parotid glands (15% of all tumors in that location).

• #90 Salivary Gland Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq

  Most patients with benign tumors of the major or minor salivary glands present with painless swelling of the parotid, submandibular, or sublingual glands. Neurological signs, such as numbness or weakness caused by nerve involvement, typically indicate a malignancy. […] Approximately 10% to 15% of malignant parotid neoplasms present with pain. However, most parotid tumors, both benign and malignant, present as an asymptomatic mass in the gland. […] Early-stage, low-grade, malignant salivary gland tumors are usually curable by adequate surgical resection alone. The prognosis is more favorable when the tumor is in a major salivary gland. The parotid gland is most favorable followed by the submandibular gland. […] Overall, clinical stage, particularly tumor size, may be the crucial factor that determines the outcome of salivary gland cancer and may be more important than histological grade.

• #91 Parotid gland tumors: a review of the epidemiology and the cito-histological correlation | Pocket Dentistry

  https://pocketdentistry.com/parotid-gland-tumors-a-review-of-the-epidemiology-and-the-cito-histological-correlation/

  Parotid gland tumors are a frequent to establish the sensitivity, specificity, and accuracy of fine-needle aspiration (FNA), for distinguishing benign from malignant lesions in the parotid gland we carried out this study. […] Moreover we studied the epidemiological facts of the parotid masses. […] Sex and age distribution of the parotid gland tumors varies in relation to the histological results. […] A 25% were malignant and a 75% benign. […] The global accuracy of the parotid gland FNA is above 70% in our study. So we do recommend the FNA as a part of the diagnostic protocol in parotid gland masses.

• #92 Active Surveillance for Pleomorphic Adenomas of the Parotid-Tumor Growth Rate, Potential Malignancy, and Surgical Sequalae.

  https://vivo.weill.cornell.edu/display/pubid39523918

  OBJECTIVE: The outcomes of active surveillance (AS) for pleomorphic adenomas (PA) as an alternative to upfront parotidectomy have not been previously documented in the literature. […] This cohort study aims to assess the safety and feasibility of AS for parotid gland PA. […] The median growth rate was 0.58 mm/year (IQR 0.04, 3.8, range -5.01 to 4.98 mm/year). […] In this selected cohort of patients with PA, the tumor growth rate was lower than traditionally believed. […] Patients who eventually underwent surgery did not suffer from serious complications and there was no evidence of clinical or pathological malignancy.

Zobacz więcej