Materiały źródłowe

• #1 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #2 Paranasal sinus cancer – UpToDate

  https://www.uptodate.com/contents/paranasal-sinus-cancer

  Paranasal sinus cancer […] INTRODUCTION […] A range of malignancies can develop in the paranasal (maxillary, ethmoid, sphenoid, frontal) sinuses. Adenocarcinoma and squamous cell carcinoma of the maxillary sinus and ethmoid sinus are the most common of these tumors. […] The epidemiology, clinical presentation, diagnosis, and management of these tumors are discussed here. Tumors arising in the nasal cavity are discussed separately. […] EPIDEMIOLOGY AND RISK FACTORS […] Cancers arising in the paranasal sinuses are rare, constituting approximately 3 percent of head and neck malignancies. The majority of these tumors arise in the maxillary sinuses, and most of the remainder start in the ethmoid sinuses. Cancers of the sphenoid and frontal sinuses are extremely rare. Paranasal sinus cancers are more frequent in males than in females. […] Factors associated with paranasal sinus cancers include: Occupational exposures – Including leather, textile, wood dust, and formaldehyde.

• #3 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Rare, < 1% of all human malignancies (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420, J Clin Med 2017;6:116) [...] Sinonasal cancers comprise 3% of all head and neck cancers (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420, J Clin Med 2017;6:116) [...] Affects 1 in 100,000 people per year worldwide (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Average age of presentation is between 50 - 70 years (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Epithelial tumors are the most common (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Sinonasal carcinomas occur more commonly in men (Nat Rev Clin Oncol 2014;11:460) [...] Male predominance is thought to be a result of occupational exposure (Nat Rev Clin Oncol 2014;11:460) [...] Woodworkers have 500 - 900 times and 20 times the risk of developing intestinal type adenocarcinoma and squamous cell carcinoma, respectively (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420)

• #4 Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data – PubMed

  https://pubmed.ncbi.nlm.nih.gov/22127982/

  The present study uses population-based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors. […] Data for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time-dependent trends in incidence and survival were analyzed by linear regression. […] The overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. […] The incidence of sinonasal cancer remained relatively stable during the study period. […] No significant changes in overall relative survival were noted. […] The prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades.

• #5 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #6

  https://biomedres.us/fulltexts/BJSTR.MS.ID.004298.php

  Carcinoma of the nasal cavity and paranasal sinuses is a rare malignancy. Due to non-specific symptoms, up to 75% of patients with paranasal sinus cancer present with advanced disease, when the tumor affects different vital structures. This circumstance determines a poor prognosis and low survival rate. […] The incidence ranges between 0.2% and 1.4% of all neoplasms and about 3% among tumors of the upper respiratory tract. In Russia in 2018 the incidence rate was 0.67 per 100.000 people. Notably, over the past 10 years there has been an increase in the incidence of almost 8%. […] Currently, up to 75% of these patients present with advanced stages, when the tumor affects different vital structures such as the orbit, zygomatic bone, pterygopalatine and temporal fossa, cranial cavity or extends to the opposite side.

• #7 Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data – PubMed

  https://pubmed.ncbi.nlm.nih.gov/22127982/

  The present study uses population-based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors. […] Data for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time-dependent trends in incidence and survival were analyzed by linear regression. […] The overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. […] The incidence of sinonasal cancer remained relatively stable during the study period. […] No significant changes in overall relative survival were noted. […] The prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades.

• #8 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #9 How Common is Nose & Sinus Cancer? | Is Nose & Sinus Cancer Rare? | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/about/key-statistics.html

  Cancers of the nasal cavity and paranasal sinuses are rare, and make up about 3% to 5% of all head and neck cancers in the United States. […] About 4 out of 5 cases occur in people who are 55 years old or older. […] In the US, White people are much more likely to develop these cancers than Black people, and men are about twice more likely than women to get these cancers. These cancers occur much more often in certain areas of the world such as Denmark. […] Most cancers of the nasal cavity and paranasal sinuses occur in the maxillary sinuses or in the nasal cavity. They are less common in the ethmoid sinuses, and are rare in the frontal and sphenoid sinuses.

• #10 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #11 Malignant Tumors of the Nasal Cavity: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/846995-overview

  A study by Gerth et al reported the overall incidence of malignant pediatric sinonasal tumors in the United States to be 0.052 per 100,000. The study, which utilized the Surveillance, Epidemiology, and End Results (SEER) database, found that rhabdomyosarcoma was the most frequently occurring malignancy among patients below age 20 years.

• #12 How Common is Nose & Sinus Cancer? | Is Nose & Sinus Cancer Rare? | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/about/key-statistics.html

  Cancers of the nasal cavity and paranasal sinuses are rare, and make up about 3% to 5% of all head and neck cancers in the United States. […] About 4 out of 5 cases occur in people who are 55 years old or older. […] In the US, White people are much more likely to develop these cancers than Black people, and men are about twice more likely than women to get these cancers. These cancers occur much more often in certain areas of the world such as Denmark. […] Most cancers of the nasal cavity and paranasal sinuses occur in the maxillary sinuses or in the nasal cavity. They are less common in the ethmoid sinuses, and are rare in the frontal and sphenoid sinuses.

• #13 How Common is Nose & Sinus Cancer? | Is Nose & Sinus Cancer Rare? | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/about/key-statistics.html

  Cancers of the nasal cavity and paranasal sinuses are rare, and make up about 3% to 5% of all head and neck cancers in the United States. […] About 4 out of 5 cases occur in people who are 55 years old or older. […] In the US, White people are much more likely to develop these cancers than Black people, and men are about twice more likely than women to get these cancers. These cancers occur much more often in certain areas of the world such as Denmark. […] Most cancers of the nasal cavity and paranasal sinuses occur in the maxillary sinuses or in the nasal cavity. They are less common in the ethmoid sinuses, and are rare in the frontal and sphenoid sinuses.

• #14 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #15 How Common is Nose & Sinus Cancer? | Is Nose & Sinus Cancer Rare? | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/about/key-statistics.html

  Cancers of the nasal cavity and paranasal sinuses are rare, and make up about 3% to 5% of all head and neck cancers in the United States. […] About 4 out of 5 cases occur in people who are 55 years old or older. […] In the US, White people are much more likely to develop these cancers than Black people, and men are about twice more likely than women to get these cancers. These cancers occur much more often in certain areas of the world such as Denmark. […] Most cancers of the nasal cavity and paranasal sinuses occur in the maxillary sinuses or in the nasal cavity. They are less common in the ethmoid sinuses, and are rare in the frontal and sphenoid sinuses.

• #16 Malignant Tumors of the Nasal Cavity: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/846995-overview

  Sinonasal malignant neoplasms are rare tumors that constitute about 3% of tumors in the upper respiratory tract. Only a fraction arises at the nasal cavity. […] The annual incidence of nasal tumors in the United States is estimated to be less than 1 in 100,000 people per year. These tumors occur most commonly in whites, and the incidence in males is twice that of females. […] Although tumors of the nasal cavities are equally divided between benign and malignant types, most tumors of the paranasal sinuses are malignant. Approximately 55% of sinonasal tumors originate from the maxillary sinuses, 35% from the nasal cavities, 9% from the ethmoid sinuses, and the remainder from the frontal and sphenoid sinuses. Squamous cell carcinoma is the most common malignant histologic type (approximately 70-80%) followed by adenoid cystic carcinoma and adenocarcinoma (approximately 10% each).

• #17 Paranasal sinus cancer – UpToDate

  https://www.uptodate.com/contents/paranasal-sinus-cancer

  Paranasal sinus cancer […] INTRODUCTION […] A range of malignancies can develop in the paranasal (maxillary, ethmoid, sphenoid, frontal) sinuses. Adenocarcinoma and squamous cell carcinoma of the maxillary sinus and ethmoid sinus are the most common of these tumors. […] The epidemiology, clinical presentation, diagnosis, and management of these tumors are discussed here. Tumors arising in the nasal cavity are discussed separately. […] EPIDEMIOLOGY AND RISK FACTORS […] Cancers arising in the paranasal sinuses are rare, constituting approximately 3 percent of head and neck malignancies. The majority of these tumors arise in the maxillary sinuses, and most of the remainder start in the ethmoid sinuses. Cancers of the sphenoid and frontal sinuses are extremely rare. Paranasal sinus cancers are more frequent in males than in females. […] Factors associated with paranasal sinus cancers include: Occupational exposures – Including leather, textile, wood dust, and formaldehyde.

• #18 Paranasal sinus cancer – UpToDate

  https://www.uptodate.com/contents/paranasal-sinus-cancer/print

  Paranasal sinus cancer […] Cancers arising in the paranasal sinuses are rare, constituting approximately 3 percent of head and neck malignancies. The majority of these tumors arise in the maxillary sinuses, and most of the remainder start in the ethmoid sinuses. Cancers of the sphenoid and frontal sinuses are extremely rare. Paranasal sinus cancers are more frequent in males than in females. […] Factors associated with paranasal sinus cancers include: Occupational exposures – Including leather, textile, wood dust, and formaldehyde.

• #19 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  The findings demonstrated that the variable „T stage” showed the strongest association, as indicated by its importance score of 0.3094. […] In the dataset adjusted with propensity score matching (PSM), the analysis revealed that chemotherapy showed no statistically significant association with overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] Delving into specific subgroups, we found that the following cohorts benefited significantly from chemotherapy: Grade IV (HR=0.59, 95% CI (0.440.79), p0.001), N1 (HR=0.55, 95% CI (0.340.90), P=0.016), N2 (HR=0.54, 95% CI (0.370.79), P=0.002), patients with primary site at the Sphenoid Sinus (HR=0.41, 95% CI (0.200.85), P=0.017), patients with histologic type as epithelial neoplasms (HR=0.61, 95% CI (0.430.88), P=0.008), and patients who had not undergone surgery or radiotherapy (HR=0.71, 95% CI (0.590.86), p0.001). […] This study presents a comprehensive examination of the occurrence and prognostic determinants of nasal cavity and paranasal sinus cancers over a period of 45 years.

• #20 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Both CT and MRI should be performed to determine anatomic details on tumor localization and extension […] Critical in determining operability or planning radiotherapy […] MRI is standard imaging modality for postoperative surveillance (Nat Rev Clin Oncol 2014;11:460) […] Role of PET CT is important in staging of squamous cell carcinoma, allowing the identification of regional and distant metastases (Cancers (Basel) 2021;13:2835, Nat Rev Clin Oncol 2014;11:460) […] Prognostic factors include age, performance status, tumor location and local extension, the histologic subtype and whether perineural invasion is present […] Carcinomas originating from the nasal cavity have a better prognosis than those from the paranasal sinuses […] This is attributed to nasal carcinomas producing symptoms that require earlier clinical attention

• #21 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Among carcinomas arising from the maxillary sinuses, those originating from the anterior inferior portion have a better prognosis than those from the superior posterior portion […] This is attributed to superior posterior tumors having accessible structures such as the orbit or skull base […] In T1 disease, 5 year survival is 80%; 30% in T4 disease […] Extensive local disease increases both surgical morbidity and local recurrence within 2 years; for example, maxillary sinus tumors have a 30 – 70% 5 year survival with resection but this drops to 10 – 20% in unresectable cases […] Intestinal type adenocarcinoma have a 50% 5 year survival after surgery and chemoradiation […] They usually grow locally, rarely involve regional lymph nodes and even more rarely give rise to distant metastases

• #22 Locally advanced paranasal sinus carcinoma: A study of 30 patients

  https://www.spandidos-publications.com/10.3892/ol.2017.5598

  Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. […] Although these tumours have a heterogeneous histology, they are commonly diagnosed as a locally advanced disease and are associated with a poor prognosis. […] Patients with SNcs are often asymptomatic in early stages and are therefore commonly diagnosed at an advanced stage (T3-4), presenting with a large primary tumour that invades the surrounding bone structures and is associated with a high frequency of poor outcome and local failure. […] Due to their rarity, there is a lack of randomized clinical trials assessing the standard treatment options for SNcs, with no clear guidelines concerning their treatment. […] Generally, surgery, whenever possible, represents the cornerstone of therapy in early (T1-2) and advanced stage (T3-4) patients, and should always be followed by adjuvant radiation therapy, except in cases of T1 low-risk disease (absence of involved surgical margins).

• #23 Malignant Tumors of the Nasal Cavity: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/846995-overview

  Sinonasal malignant neoplasms are rare tumors that constitute about 3% of tumors in the upper respiratory tract. Only a fraction arises at the nasal cavity. […] The annual incidence of nasal tumors in the United States is estimated to be less than 1 in 100,000 people per year. These tumors occur most commonly in whites, and the incidence in males is twice that of females. […] Although tumors of the nasal cavities are equally divided between benign and malignant types, most tumors of the paranasal sinuses are malignant. Approximately 55% of sinonasal tumors originate from the maxillary sinuses, 35% from the nasal cavities, 9% from the ethmoid sinuses, and the remainder from the frontal and sphenoid sinuses. Squamous cell carcinoma is the most common malignant histologic type (approximately 70-80%) followed by adenoid cystic carcinoma and adenocarcinoma (approximately 10% each).

• #24 Malignant Tumors of the Nasal Cavity: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/846995-overview

  Sinonasal malignant neoplasms are rare tumors that constitute about 3% of tumors in the upper respiratory tract. Only a fraction arises at the nasal cavity. […] The annual incidence of nasal tumors in the United States is estimated to be less than 1 in 100,000 people per year. These tumors occur most commonly in whites, and the incidence in males is twice that of females. […] Although tumors of the nasal cavities are equally divided between benign and malignant types, most tumors of the paranasal sinuses are malignant. Approximately 55% of sinonasal tumors originate from the maxillary sinuses, 35% from the nasal cavities, 9% from the ethmoid sinuses, and the remainder from the frontal and sphenoid sinuses. Squamous cell carcinoma is the most common malignant histologic type (approximately 70-80%) followed by adenoid cystic carcinoma and adenocarcinoma (approximately 10% each).

• #25 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #26 Epidemiology and clinical characteristics of the sinon…

  https://otolaryngologypl.com/seo/article/01.3001.0000.6314/en

  Epidemiology and clinical characteristics of the sinonasal malignancies […] Introduction. Sinonasal malignances (SNM) usually present as a difficult diagnostic and therapeutic problem. In the paper presented, the epidemiological and clinical characteristics of SNM, diagnosed in Holy Cross Cancer Center in Kielce (Dept. of Otolaryngology, Head and Neck Surgery), from 2001 to 2007, as well as a calculated survival rates are discussed. […] Results. In the analyzed group of 87 cases, ranging from 8 to 82 years of age (average 62,3 years), there was 48 male, and 39 female patients (M : F = 1,2 : 1). 59,8% of all group was in the age above 60 years, with the most common age group 71-80 years (33,3%). The most common defined localization was a maxillary sinus (33,3%), but due to very advanced stage at time of diagnosis in 37,9% of cases, the precise localization within the region was not possible to define. The primary epithelial tumors were diagnosed in 52,9% (n = 46), of all SNM, the non epithelial malignant tumors in 42,5% (n = 37), and metastatic tumors to the nose and paranasal sinuses in 4,6% (n = 4). In the group of epithelial SNM the Squamous cell carcinoma dominated (26/46–56,5%), and in the non epithelial SNM the most common group was a malignant lymphoma (10/37–27,0%). At time of diagnosis the majority of patients with epithelial SNM (80,4%) presented with advanced local stage of the disease (T3+T4a+T4b). The combined modality treatment was applied in the most of patients in the analyzed group (79,3%). The probability of 3 years disease free survival, calculated with Kaplan-Meier method was 64,0%, and 5-years survival – 45,0%.

• #27 Epidemiology and clinical characteristics of the sinon…

  https://otolaryngologypl.com/seo/article/01.3001.0000.6314/en

  Epidemiology and clinical characteristics of the sinonasal malignancies […] Introduction. Sinonasal malignances (SNM) usually present as a difficult diagnostic and therapeutic problem. In the paper presented, the epidemiological and clinical characteristics of SNM, diagnosed in Holy Cross Cancer Center in Kielce (Dept. of Otolaryngology, Head and Neck Surgery), from 2001 to 2007, as well as a calculated survival rates are discussed. […] Results. In the analyzed group of 87 cases, ranging from 8 to 82 years of age (average 62,3 years), there was 48 male, and 39 female patients (M : F = 1,2 : 1). 59,8% of all group was in the age above 60 years, with the most common age group 71-80 years (33,3%). The most common defined localization was a maxillary sinus (33,3%), but due to very advanced stage at time of diagnosis in 37,9% of cases, the precise localization within the region was not possible to define. The primary epithelial tumors were diagnosed in 52,9% (n = 46), of all SNM, the non epithelial malignant tumors in 42,5% (n = 37), and metastatic tumors to the nose and paranasal sinuses in 4,6% (n = 4). In the group of epithelial SNM the Squamous cell carcinoma dominated (26/46–56,5%), and in the non epithelial SNM the most common group was a malignant lymphoma (10/37–27,0%). At time of diagnosis the majority of patients with epithelial SNM (80,4%) presented with advanced local stage of the disease (T3+T4a+T4b). The combined modality treatment was applied in the most of patients in the analyzed group (79,3%). The probability of 3 years disease free survival, calculated with Kaplan-Meier method was 64,0%, and 5-years survival – 45,0%.

• #28 Sinonasal adenocarcinoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sinonasal-adenocarcinoma?lang=us

  Sinonasal adenocarcinomas are the third most common sinonasal malignancy, accounting for 5-10% of all sinonasal malignancies. Males are most affected (75-90%) between 55-60 years of age. […] Intestinal type adenocarcinomas are strongly associated with wood dust exposure, with wood-workers having a 900-1000x increased risk in comparison to the normal population. These exposure-related sinonasal adenocarcinomas tend to appear in the ethmoidal sinuses and nasal cavity (which has a higher presence of inhaled promoters), whilst non-exposure-related adenocarcinomas arise more frequently in the maxillary sinus, similar to other non-glandular sinonasal carcinomas.

• #29 Sinonasal adenocarcinoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sinonasal-adenocarcinoma?lang=us

  Sinonasal adenocarcinomas are the third most common sinonasal malignancy, accounting for 5-10% of all sinonasal malignancies. Males are most affected (75-90%) between 55-60 years of age. […] Intestinal type adenocarcinomas are strongly associated with wood dust exposure, with wood-workers having a 900-1000x increased risk in comparison to the normal population. These exposure-related sinonasal adenocarcinomas tend to appear in the ethmoidal sinuses and nasal cavity (which has a higher presence of inhaled promoters), whilst non-exposure-related adenocarcinomas arise more frequently in the maxillary sinus, similar to other non-glandular sinonasal carcinomas.

• #30 Sinonasal adenocarcinoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sinonasal-adenocarcinoma?lang=us

  Sinonasal adenocarcinomas are the third most common sinonasal malignancy, accounting for 5-10% of all sinonasal malignancies. Males are most affected (75-90%) between 55-60 years of age. […] Intestinal type adenocarcinomas are strongly associated with wood dust exposure, with wood-workers having a 900-1000x increased risk in comparison to the normal population. These exposure-related sinonasal adenocarcinomas tend to appear in the ethmoidal sinuses and nasal cavity (which has a higher presence of inhaled promoters), whilst non-exposure-related adenocarcinomas arise more frequently in the maxillary sinus, similar to other non-glandular sinonasal carcinomas.

• #31 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #32 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  Studies on the epidemiological characteristics, treatment strategies and prognosis of nasal and paranasal sinus cancer are still relatively limited. […] This study analyzed the age-adjusted incidence rates of nasal and paranasal sinus cancer from 1975 to 2020 using SEER database data. […] The annual percent change (APC) in incidence rates per 100 000 person-years was 0.36 until 2012, subsequently decreasing to 1.79. […] Chemotherapy did not significantly influence overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] This study revealed a declining trend in incidence rates beginning in 2012. […] The gradient boosting model demonstrated robust performance, playing a crucial role in predicting patient prognosis and the significance of chemotherapy. […] The incidence of nasal cavity and paranasal sinus cancers is about 5% of all head and neck cancers, and about 1% of all malignancies.

• #33

  https://link.springer.com/article/10.1007/BF00497467

  Canadian patterns of morbidity and mortality from malignancies of the nasal cavities, the paranasal sinuses and the middle ear for the periods 19701980 and 19701984 have been examined. […] Age-standardized morbidity rates have not changed significantly during 19701980 for either males (P=0.65) or females (P=0.96). […] For females, rates of change for seven of eight age groups examined also failed to achieve statistical significance (P=0.30). […] However, rates for females aged 4554 have shown an increase of 0.35 additional new cases per 1,000,000 population per year. This finding is of borderline significance (P=0.051). […] In contrast, age-standardized mortality rates have declined significantly during 19701984 by, on average, 0.08 and 0.07 fewer deaths per 1,000,000 population per year in males and females respectively.

• #34

  https://link.springer.com/article/10.1007/BF00497467

  Canadian patterns of morbidity and mortality from malignancies of the nasal cavities, the paranasal sinuses and the middle ear for the periods 19701980 and 19701984 have been examined. […] Age-standardized morbidity rates have not changed significantly during 19701980 for either males (P=0.65) or females (P=0.96). […] For females, rates of change for seven of eight age groups examined also failed to achieve statistical significance (P=0.30). […] However, rates for females aged 4554 have shown an increase of 0.35 additional new cases per 1,000,000 population per year. This finding is of borderline significance (P=0.051). […] In contrast, age-standardized mortality rates have declined significantly during 19701984 by, on average, 0.08 and 0.07 fewer deaths per 1,000,000 population per year in males and females respectively.

• #35 Risk factors for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/risks

  A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. Being exposed to wood dust is the most important risk factor for cancer of the nasal cavity or a paranasal sinus. […] Cancer of the nasal cavity or a paranasal sinus is rare, so it can be hard to figure out what increases the risk for this type of cancer. It is found more often in people older than 40 years of age. More men develop this type of cancer than women, probably because men are more likely to work in the industries that expose them to the risk factors. […] There is convincing evidence that the following factors increase your risk for cancer of the nasal cavity or a paranasal sinus. […] Being exposed to large amounts of wood dust is an important risk factor for developing cancer of the nasal cavity or a paranasal sinus, especially adenocarcinoma. The risk is high in industries like furniture and cabinet making, sawmill works and carpentry.

• #36 Cancer of the Nasal Cavity and Nasopharynx

  https://www.health.ny.gov/statistics/cancer/registry/abouts/nasal.htm

  At this time, the causes of cancer of the nasal cavity and nasopharynx are not well understood. However, scientists agree that certain factors increase a person’s risk of developing this disease. […] Risk factors for both cancers include: Smoking. People who smoke have an increased risk of getting nasal cavity cancer and cancer of the nasopharynx. […] Risk factors for nasal cavity cancer include: Workplace exposures. Workplace exposures to high levels of certain types of dusts, including wood dust, nickel dust, leather dust and textile dust, have been associated with increased risk of nasal cavity cancer. […] Risk factors for cancer of the nasopharynx include: Salted fish and other preserved foods. The higher rates of cancer of the nasopharynx among people from China and southeast Asia have been linked with eating salted preserved fish, a part of the traditional diet in this region of the world.

• #37 Paranasal sinus cancer – UpToDate

  https://www.uptodate.com/contents/paranasal-sinus-cancer

  Paranasal sinus cancer […] INTRODUCTION […] A range of malignancies can develop in the paranasal (maxillary, ethmoid, sphenoid, frontal) sinuses. Adenocarcinoma and squamous cell carcinoma of the maxillary sinus and ethmoid sinus are the most common of these tumors. […] The epidemiology, clinical presentation, diagnosis, and management of these tumors are discussed here. Tumors arising in the nasal cavity are discussed separately. […] EPIDEMIOLOGY AND RISK FACTORS […] Cancers arising in the paranasal sinuses are rare, constituting approximately 3 percent of head and neck malignancies. The majority of these tumors arise in the maxillary sinuses, and most of the remainder start in the ethmoid sinuses. Cancers of the sphenoid and frontal sinuses are extremely rare. Paranasal sinus cancers are more frequent in males than in females. […] Factors associated with paranasal sinus cancers include: Occupational exposures – Including leather, textile, wood dust, and formaldehyde.

• #38 Risk factors for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/risks

  People working in shoe and boot manufacturing have a higher risk of developing cancer of the nasal cavity or a paranasal sinus, especially when they are exposed to leather dust. […] Smoking tobacco increases the risk of developing cancer of the nasal cavity or a paranasal sinus. […] Being exposed to dust or chemicals from certain nickel compounds (nickel sulphides and oxides) in the nickel-refining industry increases the risk for cancer of the nasal cavity or a paranasal sinus. […] Retinoblastoma is an eye cancer that develops in children. Children with the hereditary form of retinoblastoma have a higher risk of developing second cancers. Treating retinoblastoma with radiation therapy increases the risk of developing cancer of the nasal cavity or a paranasal sinus later on.

• #39 Cancer of the Nasal Cavity and Nasopharynx

  https://www.health.ny.gov/statistics/cancer/registry/abouts/nasal.htm

  At this time, the causes of cancer of the nasal cavity and nasopharynx are not well understood. However, scientists agree that certain factors increase a person’s risk of developing this disease. […] Risk factors for both cancers include: Smoking. People who smoke have an increased risk of getting nasal cavity cancer and cancer of the nasopharynx. […] Risk factors for nasal cavity cancer include: Workplace exposures. Workplace exposures to high levels of certain types of dusts, including wood dust, nickel dust, leather dust and textile dust, have been associated with increased risk of nasal cavity cancer. […] Risk factors for cancer of the nasopharynx include: Salted fish and other preserved foods. The higher rates of cancer of the nasopharynx among people from China and southeast Asia have been linked with eating salted preserved fish, a part of the traditional diet in this region of the world.

• #40 Risk factors for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/risks

  People working in shoe and boot manufacturing have a higher risk of developing cancer of the nasal cavity or a paranasal sinus, especially when they are exposed to leather dust. […] Smoking tobacco increases the risk of developing cancer of the nasal cavity or a paranasal sinus. […] Being exposed to dust or chemicals from certain nickel compounds (nickel sulphides and oxides) in the nickel-refining industry increases the risk for cancer of the nasal cavity or a paranasal sinus. […] Retinoblastoma is an eye cancer that develops in children. Children with the hereditary form of retinoblastoma have a higher risk of developing second cancers. Treating retinoblastoma with radiation therapy increases the risk of developing cancer of the nasal cavity or a paranasal sinus later on.

• #41 Cancer of the Nasal Cavity and Nasopharynx

  https://www.health.ny.gov/statistics/cancer/registry/abouts/nasal.htm

  Epstein-Barr virus. Infection with the Epstein-Barr virus (EBV) has been linked to increased risk for cancer of the nasopharynx. […] The nasal cavity and nasopharynx are located next to each other, so they both might be affected by the same inhaled substances. […] Additional research is needed to determine the role, if any, these factors may have in the development of cancers of the nasal cavity and nasopharynx. […] To help reduce the risk of getting cancer of the nasal cavity and nasopharynx: Do not smoke. If you currently smoke, quit. Avoid exposure to secondhand smoke. […] Limit your consumption of salted, preserved fish. It is especially important not to give these foods to very young children.

• #42 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Leather dust, glues, formaldehyde, chrome, nickel, flour, textiles and organic solvents have also been associated with sinonasal carcinomas, mostly squamous cell carcinoma (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] Smoking is also a risk factor, although not as strongly associated as other head and neck cancers (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] HPV 16 and 18 are associated with squamous cell carcinoma (~30% of cases) (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] Other lower risk factors include nasal polyposis, inverted sinonasal papilloma, chronic sinusitis and radiotherapy used in the treatment of retinoblastoma (Curr Oncol 2021;28:2420) […] Rigid nasal endoscopy […] Noninvasive imaging is essential in establishing the extent of the tumor (Nat Rev Clin Oncol 2014;11:460)

• #43 Risk factors for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/risks

  People working in shoe and boot manufacturing have a higher risk of developing cancer of the nasal cavity or a paranasal sinus, especially when they are exposed to leather dust. […] Smoking tobacco increases the risk of developing cancer of the nasal cavity or a paranasal sinus. […] Being exposed to dust or chemicals from certain nickel compounds (nickel sulphides and oxides) in the nickel-refining industry increases the risk for cancer of the nasal cavity or a paranasal sinus. […] Retinoblastoma is an eye cancer that develops in children. Children with the hereditary form of retinoblastoma have a higher risk of developing second cancers. Treating retinoblastoma with radiation therapy increases the risk of developing cancer of the nasal cavity or a paranasal sinus later on.

• #44 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Leather dust, glues, formaldehyde, chrome, nickel, flour, textiles and organic solvents have also been associated with sinonasal carcinomas, mostly squamous cell carcinoma (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] Smoking is also a risk factor, although not as strongly associated as other head and neck cancers (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] HPV 16 and 18 are associated with squamous cell carcinoma (~30% of cases) (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) […] Other lower risk factors include nasal polyposis, inverted sinonasal papilloma, chronic sinusitis and radiotherapy used in the treatment of retinoblastoma (Curr Oncol 2021;28:2420) […] Rigid nasal endoscopy […] Noninvasive imaging is essential in establishing the extent of the tumor (Nat Rev Clin Oncol 2014;11:460)

• #45 Chronic Sinusitis Linked to Head and Neck Cancers in Elderly

  https://www.cancernetwork.com/view/chronic-sinusitis-linked-head-and-neck-cancers-elderly

  Chronic sinusitis is associated with three rare types of head and neck cancer, including nasopharyngeal cancer, HPV-related oropharyngeal cancer, and nasal cavity and paranasal sinus cancers. […] Chronic sinusitis was associated with a risk of developing head and neck cancer (adjusted hazard ratio [aHR], 1.37). The risk was highest for nasopharyngeal cancer (aHR, 3.71), HPV-related oropharyngeal cancer (aHR, 1.33), and nasal cavity and paranasal sinus cancer (aHR, 5.49). […] The authors conducted a case-cohort study using the Surveillance, Epidemiology, and End Results (SEER) Medicare database to assess this link among elderly individuals in the United States. […] Overall, the risk of any cancer type was 8% higher among individuals diagnosed with chronic sinusitis compared to those with no chronic sinusitis (aHR, 1.08). […] Future studies are necessary to consider whether inflammation in patients with sinusitis contributes to tumorigenesis, especially in middle-aged adults, concluded the editorial authors.

• #46 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Rare, < 1% of all human malignancies (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420, J Clin Med 2017;6:116) [...] Sinonasal cancers comprise 3% of all head and neck cancers (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420, J Clin Med 2017;6:116) [...] Affects 1 in 100,000 people per year worldwide (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Average age of presentation is between 50 - 70 years (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Epithelial tumors are the most common (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420) [...] Sinonasal carcinomas occur more commonly in men (Nat Rev Clin Oncol 2014;11:460) [...] Male predominance is thought to be a result of occupational exposure (Nat Rev Clin Oncol 2014;11:460) [...] Woodworkers have 500 - 900 times and 20 times the risk of developing intestinal type adenocarcinoma and squamous cell carcinoma, respectively (Nat Rev Clin Oncol 2014;11:460, Curr Oncol 2021;28:2420)

• #47 Paranasal sinus and nasal cavity cancer – Wikipedia

  https://en.wikipedia.org/wiki/Paranasal_sinus_and_nasal_cavity_cancer

  Paranasal sinus and nasal cavity cancer is a type of cancer that is caused by the appearance and spread of malignant cells into the paranasal sinus and nasal cavity. The cancer most commonly occurs in people between 50 and 70 years old, and occurs twice as often in males as in females. […] People with early stage nasal cavity or paranasal sinus cancer often do not show any symptoms, therefore, these types of cancer are usually diagnosed in the later stages. Nasal cavity or paranasal sinus cancer is often discovered when a person is being treated for a seemingly benign, inflammatory disease of the sinuses, such as sinusitis. […] Environmental factors are likely one of the main causes of paranasal sinus and nasal cavity cancer. Exposure to wood dust and nickel dust may cause paranasal sinus and nasal cavity tumors. Exposure to radium fumes, formaldehyde fumes and other substances used in the production of leather and other textiles may also increase the risk. Exposure to air pollution may also increase the risk of getting the cancer. […] Various treatments can be implemented to treat paranasal sinus and nasal cavity cancer. Generally, treatment uses methods such as surgery, radiation therapy, chemotherapy and proton therapy.

• #48 Paranasal Sinus and Nasal Cavity Cancer Overview | AACR

  https://www.aacr.org/patients-caregivers/cancer/paranasal-sinus-and-nasal-cavity-cancer/

  Paranasal sinus and nasal cavity cancer is a type of head and neck cancer. […] Risk factors for paranasal sinus and nasal cavity cancer include smoking and human papillomavirus (HPV) infection as well as exposure to certain chemicals or dust during furniture making, sawmill work, woodworking, shoemaking, and flour mill or bakery work. […] The majority of these tumors are discovered at advanced stages when cure rates are generally poor.

• #49 Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data – PubMed

  https://pubmed.ncbi.nlm.nih.gov/22127982/

  The present study uses population-based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors. […] Data for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time-dependent trends in incidence and survival were analyzed by linear regression. […] The overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. […] The incidence of sinonasal cancer remained relatively stable during the study period. […] No significant changes in overall relative survival were noted. […] The prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades.

• #50 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #51 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #52 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  Current research indicates inconsistent survival rates for nasal cavity and paranasal sinus cancer prognosis, with overall 5-year survival rates ranging from 20 to 60%. […] This uncertainty stems from the lack of targeted randomized trials in this patient cohort, highlighting a critical gap in current understanding of treatment strategies for these cancers. […] The integration of machine learning, epidemiological methods, and database applications can enhance disease understanding and model development. […] The study documented patient survival rates as follows: the one-year survival rate was 77% (95% CI 7679%), the 3-year survival rate was 58% (95% CI 5760%), and the 5-year survival rate was 49% (95% CI 4851%). […] The impact of treatment strategies exhibited variability, with radiation therapy (HR=0.872) and surgery (HR=0.658) being significant factors in improving survival. However, the effect of chemotherapy (HR=0.820) was relatively ambiguous.

• #53 Survival For Nasal And Paranasal Sinus Cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/survival

  For people diagnosed with nasal cavity or paranasal sinus cancer in the UK and Ireland: more than 70 out of 100 people (more than 70%) will survive their cancer for 1 year or more after diagnosis; around 50 out of 100 people (around 50%) will survive their cancer for 5 years or more after they are diagnosed. […] These statistics are for relative survival. Relative survival takes into account that some people will die of causes other than cancer. This gives a more accurate picture of cancer survival.

• #54 Survival For Nasal And Paranasal Sinus Cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/survival

  There are no UK wide statistics available for nasal and paranasal sinus cancer survival by stage. […] The statistics below come from America. They come from the National Cancer Institute’s SEER programme. They are for people diagnosed with nasal and paranasal sinus cancer between 2012 and 2018. […] The American statistics are split into 3 stage groups localised, regional and distant cancers. […] The statistics cover both nasal and paranasal sinus cancers. […] Around 85 out of 100 people (around 85%) survive their cancer for 5 years or more after diagnosis. […] More than 50 out of 100 people (more than 50%) survive their cancer for 5 years or more after diagnosis. […] Almost 45 out of 100 people (almost 45%) survive their cancer for 5 years or more after diagnosis. […] There are no UK wide statistics for nasal cavity or paranasal sinus cancer survival.

• #55

• #56 Sinus Cancer: Symptoms, Treatment, Prognosis

  https://www.verywellhealth.com/sinus-cancer-5197527

  Sinus cancer is a malignancy that develops in the open spaces behind your nose, called sinuses. It makes up about 3 to 5% of all head and neck cancers and can have long-lasting and devastating effects if not treated early. […] Each year, about 2,000 people are diagnosed with nasal cavity or paranasal sinus cancer in the United States. […] The SEER (Surveillance, Epidemiology, and End Results) database, maintained by the National Cancer Institute (NCI) found that the five-year survival of those with sinus cancer from 2010-2016 was 82% if the cancer was captured locally, 52% if it was found regionally, and 43% if it was found in a distant phase, underscoring the importance of early diagnosis and treatment. […] Early detection and treatment increases the likelihood of complete removal of the tumor and decreases the chances of the cancer returning.

• #57 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Among carcinomas arising from the maxillary sinuses, those originating from the anterior inferior portion have a better prognosis than those from the superior posterior portion […] This is attributed to superior posterior tumors having accessible structures such as the orbit or skull base […] In T1 disease, 5 year survival is 80%; 30% in T4 disease […] Extensive local disease increases both surgical morbidity and local recurrence within 2 years; for example, maxillary sinus tumors have a 30 – 70% 5 year survival with resection but this drops to 10 – 20% in unresectable cases […] Intestinal type adenocarcinoma have a 50% 5 year survival after surgery and chemoradiation […] They usually grow locally, rarely involve regional lymph nodes and even more rarely give rise to distant metastases

• #58 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Among carcinomas arising from the maxillary sinuses, those originating from the anterior inferior portion have a better prognosis than those from the superior posterior portion […] This is attributed to superior posterior tumors having accessible structures such as the orbit or skull base […] In T1 disease, 5 year survival is 80%; 30% in T4 disease […] Extensive local disease increases both surgical morbidity and local recurrence within 2 years; for example, maxillary sinus tumors have a 30 – 70% 5 year survival with resection but this drops to 10 – 20% in unresectable cases […] Intestinal type adenocarcinoma have a 50% 5 year survival after surgery and chemoradiation […] They usually grow locally, rarely involve regional lymph nodes and even more rarely give rise to distant metastases

• #59 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Among carcinomas arising from the maxillary sinuses, those originating from the anterior inferior portion have a better prognosis than those from the superior posterior portion […] This is attributed to superior posterior tumors having accessible structures such as the orbit or skull base […] In T1 disease, 5 year survival is 80%; 30% in T4 disease […] Extensive local disease increases both surgical morbidity and local recurrence within 2 years; for example, maxillary sinus tumors have a 30 – 70% 5 year survival with resection but this drops to 10 – 20% in unresectable cases […] Intestinal type adenocarcinoma have a 50% 5 year survival after surgery and chemoradiation […] They usually grow locally, rarely involve regional lymph nodes and even more rarely give rise to distant metastases

• #60 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Papillary type and colonic type tumors have a better prognosis than solid or mucinous subtypes […] p53 and nuclear expression of beta catenin is associated with worse prognosis […] Histologic grade does not have prognostic value in sinonasal squamous cell carcinoma but molecular markers do […] EGFR overexpression and HPV negativity in squamous cell carcinoma is associated with worse prognosis […] p16 overexpression with EGFR negativity has a better prognosis.

• #61 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Papillary type and colonic type tumors have a better prognosis than solid or mucinous subtypes […] p53 and nuclear expression of beta catenin is associated with worse prognosis […] Histologic grade does not have prognostic value in sinonasal squamous cell carcinoma but molecular markers do […] EGFR overexpression and HPV negativity in squamous cell carcinoma is associated with worse prognosis […] p16 overexpression with EGFR negativity has a better prognosis.

• #62 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Papillary type and colonic type tumors have a better prognosis than solid or mucinous subtypes […] p53 and nuclear expression of beta catenin is associated with worse prognosis […] Histologic grade does not have prognostic value in sinonasal squamous cell carcinoma but molecular markers do […] EGFR overexpression and HPV negativity in squamous cell carcinoma is associated with worse prognosis […] p16 overexpression with EGFR negativity has a better prognosis.

• #63 Pathology Outlines – Sinonasal carcinoma-general

  https://www.pathologyoutlines.com/topic/nasalcarcinomageneral.html

  Papillary type and colonic type tumors have a better prognosis than solid or mucinous subtypes […] p53 and nuclear expression of beta catenin is associated with worse prognosis […] Histologic grade does not have prognostic value in sinonasal squamous cell carcinoma but molecular markers do […] EGFR overexpression and HPV negativity in squamous cell carcinoma is associated with worse prognosis […] p16 overexpression with EGFR negativity has a better prognosis.

• #64 Locally advanced paranasal sinus carcinoma: A study of 30 patients

  https://www.spandidos-publications.com/10.3892/ol.2017.5598

  The outcome of patients with SNc also depends on histological type, and prognosis is poorer in patients with squamous cell carcinoma compared with adenocarcinoma. […] Advanced disease is often treated with exclusive chemotherapy even if SNCs are poorly chemosensitive. […] The current study also discusses the best therapy choice for locally advanced disease. […] Advanced stage at diagnosis is acknowledged to have a strong impact on prognosis and, in particular, on the probability of recurrence. […] In clinical trials, it has been observed that locally advanced diseases, namely those with intracranial extension and/or orbital apex involvement, are characterized by a poor prognosis and shorter disease-free survival, OS and PFS. […] Patients require accurate selection of treatment in order to maximise response to therapy and survival.

• #65 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  The findings demonstrated that the variable „T stage” showed the strongest association, as indicated by its importance score of 0.3094. […] In the dataset adjusted with propensity score matching (PSM), the analysis revealed that chemotherapy showed no statistically significant association with overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] Delving into specific subgroups, we found that the following cohorts benefited significantly from chemotherapy: Grade IV (HR=0.59, 95% CI (0.440.79), p0.001), N1 (HR=0.55, 95% CI (0.340.90), P=0.016), N2 (HR=0.54, 95% CI (0.370.79), P=0.002), patients with primary site at the Sphenoid Sinus (HR=0.41, 95% CI (0.200.85), P=0.017), patients with histologic type as epithelial neoplasms (HR=0.61, 95% CI (0.430.88), P=0.008), and patients who had not undergone surgery or radiotherapy (HR=0.71, 95% CI (0.590.86), p0.001). […] This study presents a comprehensive examination of the occurrence and prognostic determinants of nasal cavity and paranasal sinus cancers over a period of 45 years.

• #66 Paranasal sinus and nasal cavity cancer – Wikipedia

  https://en.wikipedia.org/wiki/Paranasal_sinus_and_nasal_cavity_cancer

  Paranasal sinus and nasal cavity cancer is a type of cancer that is caused by the appearance and spread of malignant cells into the paranasal sinus and nasal cavity. The cancer most commonly occurs in people between 50 and 70 years old, and occurs twice as often in males as in females. […] People with early stage nasal cavity or paranasal sinus cancer often do not show any symptoms, therefore, these types of cancer are usually diagnosed in the later stages. Nasal cavity or paranasal sinus cancer is often discovered when a person is being treated for a seemingly benign, inflammatory disease of the sinuses, such as sinusitis. […] Environmental factors are likely one of the main causes of paranasal sinus and nasal cavity cancer. Exposure to wood dust and nickel dust may cause paranasal sinus and nasal cavity tumors. Exposure to radium fumes, formaldehyde fumes and other substances used in the production of leather and other textiles may also increase the risk. Exposure to air pollution may also increase the risk of getting the cancer. […] Various treatments can be implemented to treat paranasal sinus and nasal cavity cancer. Generally, treatment uses methods such as surgery, radiation therapy, chemotherapy and proton therapy.

• #67 Paranasal sinus and nasal cavity cancer – Wikipedia

  https://en.wikipedia.org/wiki/Paranasal_sinus_and_nasal_cavity_cancer

  Paranasal sinus and nasal cavity cancer is a type of cancer that is caused by the appearance and spread of malignant cells into the paranasal sinus and nasal cavity. The cancer most commonly occurs in people between 50 and 70 years old, and occurs twice as often in males as in females. […] People with early stage nasal cavity or paranasal sinus cancer often do not show any symptoms, therefore, these types of cancer are usually diagnosed in the later stages. Nasal cavity or paranasal sinus cancer is often discovered when a person is being treated for a seemingly benign, inflammatory disease of the sinuses, such as sinusitis. […] Environmental factors are likely one of the main causes of paranasal sinus and nasal cavity cancer. Exposure to wood dust and nickel dust may cause paranasal sinus and nasal cavity tumors. Exposure to radium fumes, formaldehyde fumes and other substances used in the production of leather and other textiles may also increase the risk. Exposure to air pollution may also increase the risk of getting the cancer. […] Various treatments can be implemented to treat paranasal sinus and nasal cavity cancer. Generally, treatment uses methods such as surgery, radiation therapy, chemotherapy and proton therapy.

• #68 Epidemiology and clinical characteristics of the sinon…

  https://otolaryngologypl.com/seo/article/01.3001.0000.6314/en

  Epidemiology and clinical characteristics of the sinonasal malignancies […] Introduction. Sinonasal malignances (SNM) usually present as a difficult diagnostic and therapeutic problem. In the paper presented, the epidemiological and clinical characteristics of SNM, diagnosed in Holy Cross Cancer Center in Kielce (Dept. of Otolaryngology, Head and Neck Surgery), from 2001 to 2007, as well as a calculated survival rates are discussed. […] Results. In the analyzed group of 87 cases, ranging from 8 to 82 years of age (average 62,3 years), there was 48 male, and 39 female patients (M : F = 1,2 : 1). 59,8% of all group was in the age above 60 years, with the most common age group 71-80 years (33,3%). The most common defined localization was a maxillary sinus (33,3%), but due to very advanced stage at time of diagnosis in 37,9% of cases, the precise localization within the region was not possible to define. The primary epithelial tumors were diagnosed in 52,9% (n = 46), of all SNM, the non epithelial malignant tumors in 42,5% (n = 37), and metastatic tumors to the nose and paranasal sinuses in 4,6% (n = 4). In the group of epithelial SNM the Squamous cell carcinoma dominated (26/46–56,5%), and in the non epithelial SNM the most common group was a malignant lymphoma (10/37–27,0%). At time of diagnosis the majority of patients with epithelial SNM (80,4%) presented with advanced local stage of the disease (T3+T4a+T4b). The combined modality treatment was applied in the most of patients in the analyzed group (79,3%). The probability of 3 years disease free survival, calculated with Kaplan-Meier method was 64,0%, and 5-years survival – 45,0%.

• #69 Nose Cancer: Nasal and Paranasal Sinus Cancers

  https://www.verywellhealth.com/nasal-cavity-and-paranasal-sinus-cancers-3999634

  Nose cancer, or cancer in the nasal cavity or the four paranasal sinuses that surround it, is a relatively rare type of cancer. It accounts for between 3% and 5% of all head and neck cancer cases in the United States each year. […] Nasal cancers affect older people most, with 80% of cases seen in those aged 55 and older, and are seen more often in people assigned male at birth. […] Most of the nasal cancer and paranasal sinus cancers are diagnosed as squamous cell carcinoma. Adenocarcinomas, which arise from gland structures and systems in your body, like your salivary glands, are the next most common type. […] In fact, a 2021 study of 184 of these cancer cases in Pakistan found more than 70% were initially diagnosed with stage IV disease. […] Cancers of the nasal cavity and paranasal sinuses are caused by several factors. Among them are genetic changes, or mutations, you may have inherited.

• #70

  https://biomedres.us/fulltexts/BJSTR.MS.ID.004298.php

  Carcinoma of the nasal cavity and paranasal sinuses is a rare malignancy. Due to non-specific symptoms, up to 75% of patients with paranasal sinus cancer present with advanced disease, when the tumor affects different vital structures. This circumstance determines a poor prognosis and low survival rate. […] The incidence ranges between 0.2% and 1.4% of all neoplasms and about 3% among tumors of the upper respiratory tract. In Russia in 2018 the incidence rate was 0.67 per 100.000 people. Notably, over the past 10 years there has been an increase in the incidence of almost 8%. […] Currently, up to 75% of these patients present with advanced stages, when the tumor affects different vital structures such as the orbit, zygomatic bone, pterygopalatine and temporal fossa, cranial cavity or extends to the opposite side.

• #71 Sinonasal Undifferentiated Carcinoma – EyeWiki

  https://eyewiki.org/Sinonasal_Undifferentiated_Carcinoma

  Sinonasal undifferentiated carcinoma (SNUC) is an extremely rare and highly aggressive malignant neoplasm of the nasal cavity and/or paranasal sinuses. […] SNUC is clinicopathologically distinctive from other tumors but is difficult to study due to its low incidence, which is estimated to be 0.02 per 100,000. […] In a study by Chambers et al. with 318 cases of SNUC in the United States, the majority of patients were male (62%) and identified as white (82.7%). […] The age-adjusted incidence rate was estimated to be 0.02 per 100,000. There are no clear risk factors.

• #72 Sinonasal Undifferentiated Carcinoma – EyeWiki

  https://eyewiki.org/Sinonasal_Undifferentiated_Carcinoma

  Sinonasal undifferentiated carcinoma (SNUC) is an extremely rare and highly aggressive malignant neoplasm of the nasal cavity and/or paranasal sinuses. […] SNUC is clinicopathologically distinctive from other tumors but is difficult to study due to its low incidence, which is estimated to be 0.02 per 100,000. […] In a study by Chambers et al. with 318 cases of SNUC in the United States, the majority of patients were male (62%) and identified as white (82.7%). […] The age-adjusted incidence rate was estimated to be 0.02 per 100,000. There are no clear risk factors.

• #73 Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data – PubMed

  https://pubmed.ncbi.nlm.nih.gov/22127982/

  The present study uses population-based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors. […] Data for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time-dependent trends in incidence and survival were analyzed by linear regression. […] The overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. […] The incidence of sinonasal cancer remained relatively stable during the study period. […] No significant changes in overall relative survival were noted. […] The prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades.

• #74 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #75 Locally advanced paranasal sinus carcinoma: A study of 30 patients

  https://www.spandidos-publications.com/10.3892/ol.2017.5598

  Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. […] Although these tumours have a heterogeneous histology, they are commonly diagnosed as a locally advanced disease and are associated with a poor prognosis. […] Patients with SNcs are often asymptomatic in early stages and are therefore commonly diagnosed at an advanced stage (T3-4), presenting with a large primary tumour that invades the surrounding bone structures and is associated with a high frequency of poor outcome and local failure. […] Due to their rarity, there is a lack of randomized clinical trials assessing the standard treatment options for SNcs, with no clear guidelines concerning their treatment. […] Generally, surgery, whenever possible, represents the cornerstone of therapy in early (T1-2) and advanced stage (T3-4) patients, and should always be followed by adjuvant radiation therapy, except in cases of T1 low-risk disease (absence of involved surgical margins).

• #76 Understanding and Treating Rare Nasal and Paranasal Sinus Cancers | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/58628/understanding-and-treating-rare-nasal-and-paranasal-sinus-cancersundefined

  Research on the epidemiology, diagnosis, and treatment of nasal cavity and paranasal sinus cancers requires greater investigation. These rare cancers account for 3-5% of head and neck neoplasms and less than 1% of all human malignancies. They are characterized by significant histological heterogeneity, diverse aetiology, biology, and clinical features, and different prognoses. Risk factors include occupational exposure to substances like wood and leather dust, textiles, and organic solvents, as well as non-occupational factors such as tobacco use, nasal polyposis, inverted sinusal papilloma, and radiation exposure. The WHO classification of these neoplasms was updated in 2022, introducing several new molecular entities. However, due to the rarity of these cancers, evidence-based therapeutic strategies are lacking, and the outcome is usually poor.

• #77 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  Current research indicates inconsistent survival rates for nasal cavity and paranasal sinus cancer prognosis, with overall 5-year survival rates ranging from 20 to 60%. […] This uncertainty stems from the lack of targeted randomized trials in this patient cohort, highlighting a critical gap in current understanding of treatment strategies for these cancers. […] The integration of machine learning, epidemiological methods, and database applications can enhance disease understanding and model development. […] The study documented patient survival rates as follows: the one-year survival rate was 77% (95% CI 7679%), the 3-year survival rate was 58% (95% CI 5760%), and the 5-year survival rate was 49% (95% CI 4851%). […] The impact of treatment strategies exhibited variability, with radiation therapy (HR=0.872) and surgery (HR=0.658) being significant factors in improving survival. However, the effect of chemotherapy (HR=0.820) was relatively ambiguous.

• #78 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  The findings demonstrated that the variable „T stage” showed the strongest association, as indicated by its importance score of 0.3094. […] In the dataset adjusted with propensity score matching (PSM), the analysis revealed that chemotherapy showed no statistically significant association with overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] Delving into specific subgroups, we found that the following cohorts benefited significantly from chemotherapy: Grade IV (HR=0.59, 95% CI (0.440.79), p0.001), N1 (HR=0.55, 95% CI (0.340.90), P=0.016), N2 (HR=0.54, 95% CI (0.370.79), P=0.002), patients with primary site at the Sphenoid Sinus (HR=0.41, 95% CI (0.200.85), P=0.017), patients with histologic type as epithelial neoplasms (HR=0.61, 95% CI (0.430.88), P=0.008), and patients who had not undergone surgery or radiotherapy (HR=0.71, 95% CI (0.590.86), p0.001). […] This study presents a comprehensive examination of the occurrence and prognostic determinants of nasal cavity and paranasal sinus cancers over a period of 45 years.

• #79

  https://biomedres.us/fulltexts/BJSTR.MS.ID.004298.php

  The main method of treatment for this disease is surgery, followed by radiotherapy. Such treatment allows for an overall 5-year survival of more than 60% of patients with a localized tumor, decreasing to 35% in stage IV disease. […] Due to the advanced stages at which paranasal sinus malignancies are presented a lot of patients are subjected to palliative treatment with use of chemotherapy. […] Thus, considering unsatisfactory cosmetic results after surgical treatment, relatively low survival rates, and difficulties in performing radiotherapy, the use of induction chemotherapy seems to be a reasonable area for investigation.

• #80 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  Current research indicates inconsistent survival rates for nasal cavity and paranasal sinus cancer prognosis, with overall 5-year survival rates ranging from 20 to 60%. […] This uncertainty stems from the lack of targeted randomized trials in this patient cohort, highlighting a critical gap in current understanding of treatment strategies for these cancers. […] The integration of machine learning, epidemiological methods, and database applications can enhance disease understanding and model development. […] The study documented patient survival rates as follows: the one-year survival rate was 77% (95% CI 7679%), the 3-year survival rate was 58% (95% CI 5760%), and the 5-year survival rate was 49% (95% CI 4851%). […] The impact of treatment strategies exhibited variability, with radiation therapy (HR=0.872) and surgery (HR=0.658) being significant factors in improving survival. However, the effect of chemotherapy (HR=0.820) was relatively ambiguous.

• #81 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  The findings demonstrated that the variable „T stage” showed the strongest association, as indicated by its importance score of 0.3094. […] In the dataset adjusted with propensity score matching (PSM), the analysis revealed that chemotherapy showed no statistically significant association with overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] Delving into specific subgroups, we found that the following cohorts benefited significantly from chemotherapy: Grade IV (HR=0.59, 95% CI (0.440.79), p0.001), N1 (HR=0.55, 95% CI (0.340.90), P=0.016), N2 (HR=0.54, 95% CI (0.370.79), P=0.002), patients with primary site at the Sphenoid Sinus (HR=0.41, 95% CI (0.200.85), P=0.017), patients with histologic type as epithelial neoplasms (HR=0.61, 95% CI (0.430.88), P=0.008), and patients who had not undergone surgery or radiotherapy (HR=0.71, 95% CI (0.590.86), p0.001). […] This study presents a comprehensive examination of the occurrence and prognostic determinants of nasal cavity and paranasal sinus cancers over a period of 45 years.

• #82 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  The findings demonstrated that the variable „T stage” showed the strongest association, as indicated by its importance score of 0.3094. […] In the dataset adjusted with propensity score matching (PSM), the analysis revealed that chemotherapy showed no statistically significant association with overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] Delving into specific subgroups, we found that the following cohorts benefited significantly from chemotherapy: Grade IV (HR=0.59, 95% CI (0.440.79), p0.001), N1 (HR=0.55, 95% CI (0.340.90), P=0.016), N2 (HR=0.54, 95% CI (0.370.79), P=0.002), patients with primary site at the Sphenoid Sinus (HR=0.41, 95% CI (0.200.85), P=0.017), patients with histologic type as epithelial neoplasms (HR=0.61, 95% CI (0.430.88), P=0.008), and patients who had not undergone surgery or radiotherapy (HR=0.71, 95% CI (0.590.86), p0.001). […] This study presents a comprehensive examination of the occurrence and prognostic determinants of nasal cavity and paranasal sinus cancers over a period of 45 years.

• #83 Press Release: Chemotherapy before surgery helps patients with nose and sinus cancer avoid debilitating eye and bone removal – ECOG-ACRIN Cancer Research Group

  https://ecog-acrin.org/chemotherapy-before-surgery-helps-patients-with-nose-and-sinus-cancer-avoid-debilitating-eye-and-bone-removal/

  Results from a clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) show a striking improvement for patients who received chemotherapy before surgery to remove advanced squamous cell-type cancer of the nose or sinus. […] These results support chemotherapy before surgery as an effective intervention to improve the preservation of vital organs, bone, and tissue in patients with nasal and paranasal sinus squamous cell carcinoma, said lead investigator Nabil F. Saba, MD. […] Despite being unable to complete the planned accrual and reach a definitive answer, the study results are striking and support the use of neoadjuvant chemotherapy as an intervention that could improve the chance of organ preservation for these patients. […] Nose and sinus cancer is a rare disease that affects about 2,000 people in the United States each year, mostly in people aged 55 and older (American Cancer Society). […] Through study EA3163, Dr. Saba and colleagues aimed to reduce morbidity for these patients. They also hope to improve the current 5-year survival rate, which is below 50%.

• #84 Locally advanced paranasal sinus carcinoma: A study of 30 patients

  https://www.spandidos-publications.com/10.3892/ol.2017.5598

  The outcome of patients with SNc also depends on histological type, and prognosis is poorer in patients with squamous cell carcinoma compared with adenocarcinoma. […] Advanced disease is often treated with exclusive chemotherapy even if SNCs are poorly chemosensitive. […] The current study also discusses the best therapy choice for locally advanced disease. […] Advanced stage at diagnosis is acknowledged to have a strong impact on prognosis and, in particular, on the probability of recurrence. […] In clinical trials, it has been observed that locally advanced diseases, namely those with intracranial extension and/or orbital apex involvement, are characterized by a poor prognosis and shorter disease-free survival, OS and PFS. […] Patients require accurate selection of treatment in order to maximise response to therapy and survival.

• #85

  https://biomedres.us/fulltexts/BJSTR.MS.ID.004298.php

  The main method of treatment for this disease is surgery, followed by radiotherapy. Such treatment allows for an overall 5-year survival of more than 60% of patients with a localized tumor, decreasing to 35% in stage IV disease. […] Due to the advanced stages at which paranasal sinus malignancies are presented a lot of patients are subjected to palliative treatment with use of chemotherapy. […] Thus, considering unsatisfactory cosmetic results after surgical treatment, relatively low survival rates, and difficulties in performing radiotherapy, the use of induction chemotherapy seems to be a reasonable area for investigation.

• #86 Epidemiology of sinonasal squamous cell carcinoma: a comprehensive analysis of 4994 patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/23775607/

  Objectives/hypothesis: To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database. […] Results: A total of 4,994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and „others” (P .05). Overall 5-, 10-, and 20-year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. […] Conclusions: The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

• #87 Identifying chemotherapy beneficiaries in nasal and paranasal sinus cancers: epidemiological trends and machine learning insights | European Journal of Medical Research | Full Text

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02425-6

  Studies on the epidemiological characteristics, treatment strategies and prognosis of nasal and paranasal sinus cancer are still relatively limited. […] This study analyzed the age-adjusted incidence rates of nasal and paranasal sinus cancer from 1975 to 2020 using SEER database data. […] The annual percent change (APC) in incidence rates per 100 000 person-years was 0.36 until 2012, subsequently decreasing to 1.79. […] Chemotherapy did not significantly influence overall mortality risk (HR=0.93, 95% CI 0.821.05, P=0.27). […] This study revealed a declining trend in incidence rates beginning in 2012. […] The gradient boosting model demonstrated robust performance, playing a crucial role in predicting patient prognosis and the significance of chemotherapy. […] The incidence of nasal cavity and paranasal sinus cancers is about 5% of all head and neck cancers, and about 1% of all malignancies.

• #88 Understanding and Treating Rare Nasal and Paranasal Sinus Cancers | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/58628/understanding-and-treating-rare-nasal-and-paranasal-sinus-cancersundefined

  Research on the epidemiology, diagnosis, and treatment of nasal cavity and paranasal sinus cancers requires greater investigation. These rare cancers account for 3-5% of head and neck neoplasms and less than 1% of all human malignancies. They are characterized by significant histological heterogeneity, diverse aetiology, biology, and clinical features, and different prognoses. Risk factors include occupational exposure to substances like wood and leather dust, textiles, and organic solvents, as well as non-occupational factors such as tobacco use, nasal polyposis, inverted sinusal papilloma, and radiation exposure. The WHO classification of these neoplasms was updated in 2022, introducing several new molecular entities. However, due to the rarity of these cancers, evidence-based therapeutic strategies are lacking, and the outcome is usually poor.

• #89 Sinus Cancer: Symptoms, Treatment, Prognosis

  https://www.verywellhealth.com/sinus-cancer-5197527

  Sinus cancer is a malignancy that develops in the open spaces behind your nose, called sinuses. It makes up about 3 to 5% of all head and neck cancers and can have long-lasting and devastating effects if not treated early. […] Each year, about 2,000 people are diagnosed with nasal cavity or paranasal sinus cancer in the United States. […] The SEER (Surveillance, Epidemiology, and End Results) database, maintained by the National Cancer Institute (NCI) found that the five-year survival of those with sinus cancer from 2010-2016 was 82% if the cancer was captured locally, 52% if it was found regionally, and 43% if it was found in a distant phase, underscoring the importance of early diagnosis and treatment. […] Early detection and treatment increases the likelihood of complete removal of the tumor and decreases the chances of the cancer returning.

• #90 Understanding and Treating Rare Nasal and Paranasal Sinus Cancers | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/58628/understanding-and-treating-rare-nasal-and-paranasal-sinus-cancersundefined

  The goal of this Research Topic is to provide a comprehensive overview of these rare cancers, from epidemiology to treatment. […] Themes pertinent to this Research Topic include, but are not limited to: – Epidemiology of nasal cavity and paranasal sinus cancers – Risk factors and aetiology – Diagnosis and histopathologic classification – Treatment strategies and outcomes – Molecular profiling and actionable alterations – Multidisciplinary management of these cancers.

• #91 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  Sinonasal malignancies (SNMs) are rare, making up 3-5% of head and neck cancers and less than 0.5% of all cancers. They are more common in Asia and Africa than in the United States. In parts of Asia, SNMs are the second most common head and neck cancer behind nasopharyngeal carcinoma. In a study that looked at SNMs reported by the SEER (Surveillance, Epidemiology, and End Results) database from 1973 to 2006, it was found that the incidence of sinonasal cancer was 0.556 cases per 100,000 population per year in the United States. Men are affected 1.8 times more often than women, and about 80% of these tumors occur in people aged 55 years or older. […] Treatment of SNM is best accomplished through a multidisciplinary team. Optimally, this includes a head and neck oncologic surgeon, reconstructive surgeon, maxillofacial prosthodontist, radiation oncologist, medical oncologist, neuroradiologist, pathologist, and neurosurgeon.

• #92 Malignant Tumors of the Sinuses: Practice Essentials, Epidemiology, Etiology

  https://emedicine.medscape.com/article/847189-overview

  As with other types of cancers, a multimodality approach in consultation with a tumor board is recommended in sinonasal malignancies (SNMs), including a head and neck surgeon and a neurosurgeon when indicated and a neuroradiologist, pathologist, radiation oncologist, and medical oncologist as active members.

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