Materiały źródłowe

• #1 Prognosis and survival for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/prognosis-and-survival

  If you have nasal cavity or paranasal sinus cancer, you may have questions about your prognosis. A prognosis is the doctor’s best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. Only a doctor familiar with your medical history, the type, stage and other features of the cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis. […] Stage is the most important prognostic factor for cancers of the nasal cavity and paranasal sinuses. The earlier a tumour in the nasal cavity or paranasal sinuses is found, the better the prognosis. Unfortunately, many tumours in the nasal cavity or paranasal sinuses are found at a later stage.

• #2 Survival statistics for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/prognosis-and-survival/survival-statistics

  Survival statistics for nasal cavity and paranasal sinus cancer are very general estimates and must be interpreted very carefully. Because these statistics are based on the experience of groups of people, they cannot be used to predict a particular person’s chances of survival. […] Survival varies with each stage of cancer. Generally, the earlier that cancer in the nasal cavity or paranasal sinuses is diagnosed and treated, the better the outcome. This type of cancer usually is not found until it is at an advanced stage, which can make it more difficult to treat. […] The 5-year relative survival rate for localized disease is 85%. […] The 5-year relative survival for regional disease is 50%. […] The 5-year relative survival for distant disease is 44%. […] Talk to your doctor about your prognosis. A prognosis depends on many factors, including: your medical history, the type of cancer, the stage, characteristics of the cancer, the treatments chosen, how the cancer responds to treatment. Only a doctor familiar with these factors can put all of this information together with survival statistics to arrive at a prognosis.

• #3 Prognosis and survival for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/prognosis-and-survival

  Tumours that have grown into the brain or the outer membrane of the brain have a poor prognosis. […] The more lymph nodes that contain cancer and the larger these lymph nodes are, the poorer the prognosis. […] Low-grade esthesioneuroblastomas, adenocarcinomas and chondrosarcomas tend to have the best prognosis. […] Squamous cell carcinomas (SCCs) tend to have a better prognosis if the cancer started in the ethmoid sinus rather than the nasal cavity or other paranasal sinuses. […] Melanoma and sinonasal undifferentiated carcinomas (SNUC) have a poor prognosis. […] Younger people tend to have a better prognosis than older people. […] Women may have a better prognosis than men. […] People who have higher performance status scores may survive longer and cope with the effects of treatment better than those who have lower scores.

• #4 Prognosis and survival for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/prognosis-and-survival

  A tumour that started in the nasal cavity or paranasal sinuses and has grown into the nasopharynx and base of the skull has a poor prognosis because it is harder to completely remove with surgery. […] If there are cancer cells in the surgical margin, it is called a positive surgical margin. Surgical margins that don’t have cancer cells are called negative surgical margins and have a better prognosis than positive surgical margins. […] People who don’t smoke or drink alcohol tend to have a better prognosis than those who smoke and drink alcohol.

• #5 Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7296471/

  We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis. […] Nodal metastasis at presentation was seen in 13.2% of patients, with the sinus subsite (19.3%) being a significant risk factor for nodal metastasis at presentation when compared to the nasal cavity (7.9%). […] In sinonasal SCC, the sinus subsite has a significantly increased risk of nodal metastasis compared to the nasal cavity. Black race, uninsured and Medicaid patients are more likely to have nodal metastasis at presentation. […] Clinical evidence of nodal metastasis was seen in 854 patients (13.2%) overall. […] For all sinus subsites (maxillary, ethmoid, sphenoid, frontal), nodal metastasis was seen in 583 patients (19.3%).

• #6 Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10148547/

  To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. […] The prognosis depends on initial tumor stage and histological subtype. Sinonasal MM in particular have a poor prognosis with 5-year overall survival (OS) rates not exceeding 42%. Other entities have a better 5-year OS with up to 92% for SCC. […] Regional involvement and regional recurrence are scarce. […] Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival. […] The oncologic outcome (initially palliatively treated cases excluded) was: no evidence of disease (n=85, 65.4%), alive with disease (n=8, 6.2%), dead without disease (n=7, 5.4%), dead of disease (n=30, 23.1%). Five-year OS of the whole cohort was 75.5%, 10-year OS was 52.1%.

• #7 Nose & Sinus Cancer ‣ Prognosis

  https://thancguide.org/cancer-types/nose-sinus/prognosis/

  A prognosis is a prediction of the outcome of ones disease. How likely is survival? Will the cancer come back? These are the big questions on most peoples minds after receiving a diagnosis of sinonasal cancer. In general, there are several characteristics of the tumor that can inform a patient about their chances of being cured. […] While each of these factors contributes to ones outcome, patients should have a discussion with their doctor to determine their overall prognosis. Giving a percentage of survival is challenging because cancer research often looks at multiple types of cancer and may include a large range of patients who underwent a variety of treatments. […] Specifically for mucosal melanoma of the nasal and sinus cavities, a few studies have looked at prognosis and found it to be quite poor. In one recent study based on SEER data, it was found that the disease-specific survival was 32% at 5 years and 19% at 10 years. This study also found that tumors of the oral cavity and nasal cavity had slightly better survival as compared with mucosal melanoma tumors in the nasopharynx and paranasal sinuses.

• #8 Survival For Nasal And Paranasal Sinus Cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/survival

  Survival depends on different factors. So no one can tell you exactly how long you will live. […] Doctors usually work out the outlook for a certain disease by looking at large groups of people. Because this cancer is less common, survival is harder to estimate than for other, more common cancers. […] Your outlook (prognosis) depends on the stage of your cancer at diagnosis. […] Around 85 out of 100 people (around 85%) survive their cancer for 5 years or more after diagnosis. […] More than 50 out of 100 people (more than 50%) survive their cancer for 5 years or more after diagnosis. […] Almost 45 out of 100 people (almost 45%) survive their cancer for 5 years or more after diagnosis. […] For people diagnosed with nasal cavity or paranasal sinus cancer in the UK and Ireland: more than 70 out of 100 people (more than 70%) will survive their cancer for 1 year or more after diagnosis; around 50 out of 100 people (around 50%) will survive their cancer for 5 years or more after they are diagnosed.

• #9 Paranasal Sinus Cancer – Ear, Nose, and Throat Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/ear-nose-and-throat-disorders/mouth-nose-and-throat-cancers/paranasal-sinus-cancer

  The earlier paranasal sinus cancer is treated, the better the prognosis. However, survival is generally poor. Overall, about 60% of people with paranasal sinus cancer live more than 5 years.

• #10 Evaluation of the Prognostic Capacity of a Novel Survival Marker in Patients with Sinonasal Squamous Cell Carcinoma

  https://www.mdpi.com/2072-6643/14/20/4337

  Evaluation of the Prognostic Capacity of a Novel Survival Marker in Patients with Sinonasal Squamous Cell Carcinoma […] Sinonasal squamous cell carcinoma (SNSCC) is a malignant tumor associated with poor survival, and easily obtainable prognostic markers are of high interest. Therefore, we aimed to assess the prognostic value of a novel survival index (SI) combining prognostic values of clinical (T and N classifications and invasion across Ohngren’s line), inflammatory (neutrophil-to-lymphocyte ratio), and nutritional (albumin and body-mass index) markers. Overall survival (OS) and disease-free survival (DFS) were compared between patients with low- and high-risk SI. The log-rank test was used to test for statistical significance. Overall, the mortality rate was 41.2% (n = 21), and the recurrence rate was 43.1% (n = 22). We observed significantly better OS in patients with low-risk SI (n = 24/51, 47.1%, mean OS: 7.9 years, 95% confidence interval (CI): 6.3–9.6 years) than in high-risk SI (n = 27/51, 52.9%, mean OS: 3.4 years, 95% CI: 2.2–4.5 years; p = 0.013). Moreover, we also showed that patients with low-risk SI had a longer DFS than patients with high-risk SI (mean DFS: 6.4, 95% CI: 4.8–8.0 vs. mean DFS: 2.4 years, 95% CI 1.3–3.5, p = 0.012). The SI combines the prognostic capacity of well-established clinical, radiologic, inflammatory, and nutritional prognosticators and showed prognostic potential in our cohort of SNSCC patients.

• #11 Evaluation of the Prognostic Capacity of a Novel Survival Marker in Patients with Sinonasal Squamous Cell Carcinoma

  https://www.mdpi.com/2072-6643/14/20/4337

  Patients with SNSCC generally have poor survival outcomes, which have not significantly improved in recent years. The reported 5-year overall survival (OS) ranges from 30% to 50%. Predicting patient outcome is still hard for this disease due to the lack of established prognostic markers. […] The overall mortality and recurrence rates were 41.2% (n = 21) and 43.1% (n = 22), respectively. The mean calculated OS and DFS for the whole cohort were 2.8 ± 2.1 years and 2.1 ± 2.0 years, respectively. When stratified into low-risk (SI 0–2, n = 24, 47.1%) and high-risk (SI 3–6, n = 27, 52.9%) status according to the SI, the log-rank test revealed significantly different survival times. Indeed, the OS was significantly longer for the low-risk group (mean OS: 7.9 years, 95% CI 6.3–9.6 years vs. mean OS: 3.4 years, 95% CI 2.2–4.5 years; p = 0.013). Similarly, the DFS was prolonged in patients with low SI (mean DFS: 6.4 years, 95% CI 4.8–8.0 vs. mean DFS: 2.4 years, 95% CI 1.3–3.5; p = 0.012). […] The present study provides evidence of the prognostic value of the newly proposed SI in patients with SNSCC. As the expected survival outcome in SNSCC patients remains poor, identifying high-risk patients is crucial in order to accordingly adapt therapy and follow-up regimes.

• #12 Survival For Nasal And Paranasal Sinus Cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/survival

  Your outlook depends on the stage of the cancer when it was diagnosed. This means how big it is and whether it has spread. […] The type of cancer and grade of the cancer cells can also affect your survival. […] Your general health and fitness also affect survival. The fitter you are, the better you may be able to cope with your cancer and treatment.

• #13 Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7296471/

  A relationship between insurance status and nodal metastasis has been shown for parotid malignancy where uninsured and Medicaid patients were more likely to present with nodal metastasis compared to private insurance. […] Our findings also showed that race was a risk factor for nodal metastasis, with black patients more likely to present with nodal metastasis compared to white patients. […] This study of 6448 patients with sinonasal SCC represents the largest study on predictors of nodal metastasis. Patient factors associated with nodal metastasis at presentation included black race, uninsured and Medicaid. Tumors factors include sinus primary site.

• #14 Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10148547/

  For the PFS of all entities, cT2 (HR 2.1, 95% CI 1.33.6; p=0.004) and cN+status (HR 2.2 (1.14.0); p=0.034) were independent adverse risk factors in the multivariate model after backwards elimination. For OS, patient age over 60 years remained in the final model as well (HR 2.4 (1.25.1), p=0.01; cT2: HR 4.4 (1.911.8), p0.001; cN+: HR 3.9 (1.78.2); p0.001). […] Long-term overall survival and incidence of the five most frequent entities. […] This study gives a comprehensive overview on sinonasal malignancies including a broad variety of histopathological and clinical entities. Regional involvement and recurrence are uncommon. A structured follow-up of the cervical lymph nodes is critical to detecting regional recurrences, especially in patients with previously untreated necks.

• #15 Survival Rates for Nasal Cavity and Paranasal Sinus Cancers | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/detection-diagnosis-staging/survival-rates.html

  Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed. […] Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they cant predict what will happen in any particular persons case. […] A relative survival rate compares people with the same type and stage of cancer to people in the overall population. […] The SEER database tracks 5-year relative survival rates for nasal cavity and paranasal sinus cancer in the United States, based on how far the cancer has spread. […] These numbers apply only to the stage of the cancer when it is first diagnosed. […] These numbers dont take everything into account. […] People now being diagnosed with nasal cavity or paranasal sinus cancer may have a better outlook than these numbers show.

• #16 Nasal and Sinus Cancers – Barrow Neurological Institutephone iconphone iconGroup 9Group 49Group 49

  https://www.barrowneuro.org/condition/nasal-and-sinus-cancer/

  The five-year survival rate can be higher for localized cancers detected early. […] The survival rates tend to be lower for cancers that have spread to nearby tissues, lymph nodes, or other body parts. […] While statistics can provide a general picture, they don’t tell the whole story. Advances in cancer treatment, including surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy, have improved outcomes for many people with nasal and sinus cancers. Additionally, factors like the cancer’s specific characteristics and the patient’s overall health are crucial in determining prognosis. […] The best source of information about your prognosis is your medical team. They will consider the abovementioned factors to tailor treatment to your situation. They also consider your quality of life, preferences, and values when recommending treatment options. […] Remember, every person’s journey with cancer is unique, and there is always hope. Ongoing research and clinical trials continue to seek out new and better ways to treat nasal and sinus cancers, aiming to improve survival rates and the quality of life for those affected.

Zobacz więcej