Wirus zika
Objawy

Wirus Zika (ZIKV), należący do rodziny Flaviviridae, jest przenoszony głównie przez komary Aedes aegypti i Aedes albopictus. Okres inkubacji wynosi 3-14 dni. U około 60-80% zakażonych przebieg jest bezobjawowy, a u 20% pojawiają się objawy takie jak łagodna gorączka (<38,9°C), plamisto-grudkowa wysypka (występująca u ~90% chorych), bóle stawów i mięśni, zapalenie spojówek oraz ból głowy. Objawy utrzymują się zwykle 2-7 dni i mają łagodny przebieg, rzadko wymagając hospitalizacji. Powikłania neurologiczne, takie jak zespół Guillaina-Barrégo (2/10 000 zakażonych), zapalenie mózgu, opon mózgowych czy rdzenia, są rzadkie, ale mogą prowadzić do ciężkich następstw, w tym paraliżu i konieczności wsparcia oddechowego. Zakażenie może także wywoływać zaburzenia krzepnięcia i małopłytkowość.

Charakterystyka wirusa zika

Wirus zika (Zika virus, ZIKV) należy do rodziny Flaviviridae i rodzaju Flavivirus. Jest to wirus RNA, który jest blisko spokrewniony z wirusami dengi, żółtej gorączki, japońskiego zapalenia mózgu i wirusem Zachodniego Nilu. Wirus zika jest przenoszony głównie przez ukąszenia komarów z rodzaju Aedes, w szczególności Aedes aegypti i Aedes albopictus, znanych również jako komar tygrysi. Okres inkubacji wirusa zika wynosi zazwyczaj od 3 do 14 dni po ukąszeniu przez zakażonego komara, choć może być krótszy lub dłuższy u niektórych osób.12

Objawy kliniczne zakażenia wirusem zika

Większość osób (około 60-80%) zakażonych wirusem zika nie rozwija żadnych objawów lub są one tak łagodne, że pozostają niezauważone. Oszacowano, że tylko około 1 na 5 osób (20%) rozwija objawy kliniczne po zakażeniu.123 Brak objawów u większości zakażonych osób stanowi wyzwanie dla właściwej diagnostyki i monitorowania rozprzestrzeniania się wirusa w populacji.4

Typowe objawy zakażenia

U osób, które rozwijają objawy, choroba jest zazwyczaj łagodna, a symptomy utrzymują się od kilku dni do tygodnia. Najczęstsze objawy zakażenia wirusem zika obejmują:12

  • Gorączkę (zwykle łagodną, poniżej 38,9°C)1
  • Wysypkę skórną (głównie plamisto-grudkową/maculopapular), często swędzącą12
  • Bóle stawów (arthralgia), szczególnie małych stawów dłoni i stóp1
  • Zapalenie spojówek (nie-ropne zapalenie, czerwone oczy)1
  • Bóle mięśni (myalgia)1
  • Ból głowy, często za oczami (ból zaoczodołowy)1

Rzadziej występujące objawy mogą obejmować:12

  • Obrzęk okołostawowy1
  • Dolegliwości żołądkowo-jelitowe (ból brzucha, nudności, wymioty, biegunka)1
  • Ból gardła1
  • Zawroty głowy1
  • Zmęczenie i obniżenie energii1

Charakterystyka wysypki

Wysypka jest jednym z najbardziej charakterystycznych objawów zakażenia wirusem zika, występującym u około 90% pacjentów z objawami.1 Może mieć charakter plamisto-grudkowy (papules) lub szkarlatynopodobny (micropapules). Zazwyczaj zaczyna się na twarzy w pierwszym dniu choroby i rozprzestrzenia się na tułów i kończyny. Może obejmować dłonie i podeszwy stóp, które mogą być obrzęknięte. Wysypka zaczyna blaknąć po 2-3 dniach i całkowicie zanika w ciągu tygodnia.1

Czas trwania objawów

Objawy zakażenia wirusem zika są zwykle łagodne i ustępują samoistnie. Typowo trwają od 2 do 7 dni. U większości osób choroba nie jest na tyle poważna, aby wymagać hospitalizacji.123 Śmiertelność w przebiegu zakażenia wirusem zika jest bardzo rzadka, występująca w mniej niż 1% przypadków.1

Progresja choroby i potencjalne powikłania

Chociaż większość zakażeń wirusem zika ma przebieg łagodny i samoograniczający się, w niektórych przypadkach mogą wystąpić poważne powikłania neurologiczne lub inne, zwłaszcza u określonych grup ryzyka.12

Zespół Guillaina-Barrégo

Rzadkim, ale poważnym powikłaniem zakażenia wirusem zika jest zespół Guillaina-Barrégo (GBS). Jest to zaburzenie autoimmunologiczne, w którym układ odpornościowy pacjenta atakuje własne komórki nerwowe, powodując osłabienie mięśni, a w niektórych przypadkach nawet paraliż.12 Szacuje się, że zespół Guillaina-Barrégo występuje u około 2 na 10 000 osób zakażonych wirusem zika.1

Objawy GBS mogą się utrzymywać od kilku tygodni do kilku miesięcy i obejmują:12

  • Osłabienie mięśni
  • Parestezje (mrowienie, drętwienie)
  • W ciężkich przypadkach – paraliż
  • Może wymagać hospitalizacji i wsparcia oddechowego

Większość osób w pełni wraca do zdrowia po przebytym zespole Guillaina-Barrégo, chociaż niektórzy pacjenci mogą mieć trwałe uszkodzenia.1 Objawy neurologiczne GBS pojawiają się zwykle około 6 dni po wystąpieniu objawów zakażenia wirusem zika.1

Inne powikłania neurologiczne

W rzadkich przypadkach wirus zika może powodować również inne poważne choroby neurologiczne, takie jak:12

  • Zapalenie mózgu (encephalitis) – obrzęk mózgu
  • Zapalenie opon mózgowych (meningitis) – zapalenie tkanek otaczających mózg
  • Zapalenie rdzenia kręgowego (myelitis)
  • Neuropatia
  • Zapalenie błony naczyniowej oka (uveitis)

Objawy zapalenia mózgu związanego z wirusem zika mogą obejmować zaburzenia świadomości, drażliwość, zmiany osobowości i drgawki, a w ciężkich przypadkach głęboką śpiączkę i śmierć.1

Zaburzenia krzepnięcia krwi

W rzadkich przypadkach wirus zika może wywoływać zaburzenia krzepnięcia krwi, które mogą prowadzić do krwawień, powstawania siniaków lub spowolnienia krzepnięcia krwi. Może również wystąpić ciężka małopłytkowość.12

Wirus zika w czasie ciąży

Szczególne znaczenie ma zakażenie wirusem zika u kobiet w ciąży, gdyż może ono prowadzić do poważnych wad wrodzonych u rozwijającego się płodu.12

Zespół wrodzonego zakażenia wirusem zika

Zakażenie wirusem zika podczas ciąży może spowodować zakażenie wrodzone z poważnymi wadami mózgu i oczu, w tym:123

  • Małogłowie (microcephaly) – nieprawidłowo mała głowa i mózg dziecka
  • Zwapnienia wewnątrzczaszkowe (intracranial calcifications)
  • Zanik mózgu lub kory mózgowej (cerebral/cortical atrophy)
  • Nieprawidłowości siatkówkowo-naczyniówkowe (chorioretinal abnormalities)
  • Nieprawidłowości nerwu wzrokowego (optic nerve abnormalities)
  • Przykurcze kończyn (limb contractures)
  • Zwiększone napięcie mięśniowe (high muscle tone)
  • Utrata słuchu (hearing loss)
  • Problemy ze wzrokiem (vision loss)

Te cechy kliniczne są wspólnie określane jako wrodzony zespół wirusa zika (congenital Zika syndrome).1 Dzieci z tym zespołem mogą doświadczać opóźnień rozwojowych, w tym problemów z mową, siedzeniem, staniem i chodzeniem. Mogą mieć również trudności z karmieniem, takie jak problemy z połykaniem.1

Powikłania ciąży

Zakażenie wirusem zika podczas ciąży wiąże się również z innymi powikłaniami ciąży, w tym:12

  • Utrata płodu
  • Poród martwego dziecka (stillbirth)
  • Poród przedwczesny (preterm birth)

Ryzyko wad wrodzonych

Nie każde dziecko, którego matka została zakażona wirusem zika podczas ciąży, rodzi się z małogłowiem lub innymi wadami wrodzonymi. Badania wskazują, że odsetek zakażeń płodu może wynosić od 1% do 13% w przypadku zakażenia matki w pierwszym trymestrze ciąży.1 Uważa się, że zakażenie we wczesnych etapach ciąży, gdy organy płodu dopiero się formują, wiąże się z najgorszymi następstwami.1

Ogólnie szacuje się, że około 5% (1 na 20) dzieci urodzonych przez osoby zakażone wirusem zika ma wady wrodzone.1 Badania sugerują, że ryzyko zakażenia płodu jest mniejsze w drugim i trzecim trymestrze, ale potrzebne są dalsze badania, aby to potwierdzić.1

Diagnostyka wad wrodzonych

Warto zauważyć, że niemowlęta z wrodzonym zakażeniem wirusem zika mogą nie wykazywać żadnych objawów przy urodzeniu, ale mogą mieć nieprawidłowości w badaniach neuroobrazowych lub następstwa kliniczne (np. utratę wzroku), które są wykrywane dopiero po urodzeniu.1 Małogłowie najłatwiej wykryć w badaniach ultrasonograficznych w późnym drugim/wczesnym trzecim trymestrze ciąży, ale może być zauważone już w 18-20 tygodniu ciąży.1

Leczenie i rokowanie

Nie istnieje specyficzne leczenie zakażenia wirusem zika ani szczepionka zapobiegająca zakażeniu. Leczenie jest głównie objawowe i wspierające.12

Leczenie objawowe

Zalecenia dotyczące leczenia objawowego obejmują:12

  • Odpoczynek
  • Nawodnienie (przyjmowanie dużej ilości płynów)
  • Leki przeciwbólowe i przeciwgorączkowe, takie jak paracetamol (np. Tylenol)
  • Unikanie aspiryny i niesteroidowych leków przeciwzapalnych do czasu wykluczenia dengi ze względu na ryzyko krwawienia

Rokowanie

Rokowanie dla większości osób zakażonych wirusem zika jest dobre. Większość zakażeń przebiega bezobjawowo lub powoduje tylko łagodne objawy, które ustępują samoistnie w ciągu tygodnia.12 Ciężka choroba wymagająca hospitalizacji jest rzadka, a zgony związane z wirusem zika zdarzają się bardzo rzadko.1

Jednak zakażenie wirusem zika podczas ciąży może mieć poważne konsekwencje dla rozwijającego się płodu, prowadząc do wad wrodzonych, które są trwałe.1 Podobnie, w przypadku rozwoju zespołu Guillaina-Barrégo jako powikłania zakażenia wirusem zika, chociaż większość osób w pełni wraca do zdrowia, niektórzy pacjenci mogą mieć trwałe uszkodzenia neurologiczne.1

Nie ma lekarstwa na wirusa zika ani na powikłania, które może powodować. Leczenie jest ukierunkowane na łagodzenie objawów, a w przypadku ciężkich powikłań neurologicznych lub wad wrodzonych – na zapewnienie odpowiedniej opieki wspierającej i rehabilitacyjnej.1

Kolejne rozdziały

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  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Infographics
    https://www.who.int/health-topics/zika-virus-disease
    Zika virus disease is primarily transmitted by the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti, in tropical and subtropical regions. The incubation period (the time from exposure to symptoms) of Zika virus disease is estimated to be 3 to 14 days. The majority of people infected with Zika virus do not develop symptoms. Symptoms are generally mild including fever, rash, conjunctivitis, muscle and joint pain, malaise, and headache, and usually last for 2 to 7 days. […] Zika virus infection during pregnancy is a cause of microcephaly and other congenital abnormalities in the developing fetus and newborn. Zika infection in pregnancy also results in pregnancy complications such as fetal loss, stillbirth, and preterm birth. […] Zika virus infection is also a trigger of Guillain-Barr syndrome, neuropathy and myelitis, particularly in adults and older children.
  • #1 Clinical Signs and Symptoms of Zika Virus Disease | Zika Virus | CDC
    https://www.cdc.gov/zika/hcp/clinical-signs/index.html
    Approximately 80% of people infected with Zika virus are asymptomatic. […] Clinical illness is typically mild, characterized by fever, arthralgia, conjunctivitis, and maculopapular rash. […] Characteristic clinical findings associated with Zika virus disease are acute onset of fever with maculopapular rash, arthralgia, or nonpurulent conjunctivitis. Other commonly reported symptoms include myalgia and headache. Clinical illness is usually mild with symptoms lasting for several days to a week. […] Severe disease requiring hospitalization is uncommon and case fatality occurs in 1% of cases. However, cases of Guillain-Barr syndrome have occurred in patients following Zika virus infection. Rarely, encephalopathy, meningoencephalitis, myelitis, uveitis, and severe thrombocytopenia can occur.
  • #1 Zika Symptoms and Complications | Zika Virus | CDC
    https://www.cdc.gov/zika/signs-symptoms/index.html
    Many people infected with Zika virus will not have symptoms or will only have mild symptoms. […] The most common symptoms of Zika virus disease (Zika) are: Fever, Rash, Headache, Joint pain, Conjunctivitis (red eyes), Muscle pain. […] Zika symptoms usually last for several days to a week. People usually do not get sick enough to go to the hospital. For this reason, many people might not realize they have been infected. […] People very rarely die of Zika. […] Zika infection during pregnancy can cause serious birth defects and is associated with other pregnancy problems, including fetal loss, stillbirth and preterm birth. […] Rarely, Zika infection may cause Guillain-Barr syndrome (GBS). GBS is a sickness in which a persons own immune system damages their nerve cells causing muscle weakness and sometimes, paralysis. These symptoms can last a few weeks or several months. Most people fully recover from GBS, though some people have permanent damage. Very few people die from GBS caused by Zika infection. […] In rare cases, Zika may cause severe disease affecting the brain, causing swelling of the brain (encephalitis), tissues around the brain (meningitis) or spinal cord (myelitis). Zika may also cause a blood disorder which can result in bleeding, bruising, or slow blood clotting.
  • #1 Zika virus cases rising: Here’s how it spreads, symptoms, prevention, and treatment – The Economic Times
    https://m.economictimes.com/news/new-updates/zika-virus-cases-rising-heres-how-it-spreads-symptoms-prevention-and-treatment/articleshow/112377544.cms
    Since June, Pune has seen 73 Zika virus cases, with four deaths among patients who had pre-existing health conditions. Symptoms include fever, conjunctivitis, and muscle pain. […] The World Health Organization (WHO) notes that Zika virus symptoms generally include rash, fever, joint pain, and headache, usually lasting for a short period. Pregnant women infected with Zika face an increased risk of complications like pregnancy loss and congenital disabilities in newborns. […] Fever: Typically low-grade, usually below 102F (38.9C), and often one of the first symptoms. Rash: A maculopapular rash with red spots and bumps, starting on the face and spreading. It is often itchy. Joint Pain: Swelling and pain in smaller joints, sometimes with muscle pain. Conjunctivitis (Red Eyes): Red, irritated eyes, similar to pink eye but without discharge. Muscle Pain: General aches and pains, similar to those from other viral infections. Headache: Mild to moderate headaches, often accompanying other symptoms. Fatigue: General tiredness and low energy, which can persist after other symptoms subside. Abdominal Pain: Less common, but some experience discomfort in the abdomen. Vomiting: Nausea and occasional vomiting, which can lead to dehydration. Eye Pain: Deep, aching pain behind the eyes, worsening with movement.
  • #1 Zika Virus – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK430981/
    Zika virus is a single-stranded RNA virus of the family and the genus Flavivirus. In the majority of people, infection by the Zika virus is mild and self-limiting. […] In most cases, Zika infection is a mild self-limited illness. Today, zika virus infection is a reportable illness. […] Most patients with acute Zika virus infections are either asymptomatic (60% to 80%) or have only mild symptoms. For Zika disease due to a mosquito bite, the estimated incubation phase between bite and symptoms is two to 14 days. In symptomatic infections, the most common symptoms/signs include: rash (90% or more), conjunctivitis (55% to 82%), fever (65% to 80%), and headache (45% to 80%). The rash is typically maculopapular, and the fever is often low grade, and short-lived. Other common symptoms and signs include arthralgia (65% to 70%, myalgia (48% to 65%), and retro-orbital pain (39% to 48%). Less commonly seen are edema, vomiting, and abdominal pain.
  • #1 Zika virus infection – including symptoms, treatment and prevention | SA Health
    https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/conditions/infectious+diseases/zika+virus+infection/zika+virus+infection+-+including+symptoms+treatment+and+prevention
    Zika virus infection is an infection in humans caused by the Zika virus. The first human cases were identified in 1952 in Uganda and Tanzania. […] Most people (80%) with Zika virus do not have any symptoms. If illness occurs, it usually lasts 4 to 7 days. Symptoms include: mild fever, rash (maculopapular), sore joints and possibly swollen joints (usually small joints of the hands and feet), muscle pain, conjunctivitis inflamed (red) eyes, usually without any discharge, headache, usually behind the eyes. […] Some people may experience fatigue and low energy levels after the initial symptoms resolve. Zika virus has been linked to: rare neurological diseases including Guillain-Barr syndrome, rare birth defects, including microcephaly (an underdeveloped brain), in babies born to mothers with Zika virus infection during pregnancy. […] Usually 3 to 12 days. […] There is no specific treatment available. General recommendations include the use of supportive treatments such as rest, fluids and medications for pain relief. […] There is no vaccine to prevent human infection by this virus.
  • #1 Zika: : Symptoms, Prevention and Treatments – PAHO/WHO
    https://www.paho.org/en/topics/zika
    Zika fever is an infectious disease caused by the Zika virus (ZIKV) and transmitted through the bite of Aedes mosquitoes infected with ZIKV. The disease is mainly characterized by a rash (mainly maculopapular and cephalocaudal distribution), pruritus, non-purulent conjunctivitis, arthralgia, myalgia, periarticular edema, and fever. […] One in four infected people may develop symptoms, but in those who are affected the disease is usually mild, with symptoms lasting between 2 and 7 days. The clinical appearance is often similar to dengue or chikungunya, also a mosquito-borne illness. […] Most people infected with ZIKV are asymptomatic. Those who develop the disease usually present a mild picture that includes rash (mainly maculopapular and cephalocaudal distribution), pruritus, non-purulent conjunctivitis, arthralgia, myalgia, periarticular edema and fever. These symptoms usually last 2 to 7 days.
  • #1 What happens when you get Zika Virus?
    https://www.vdci.net/blog/zika-virus-fact-brochure-aedes-mosquitoes-control/
    Symptoms of Zika infection: Typically, people with ZIKV infection begin showing symptoms with a mild headache. Within a day or two, a maculopapular rash may appear and can cover many parts of the body (arms, hands, face, and chest). Following the rash, people generally report continued fever, malaise, and body aches. Other symptoms can include diarrhea, constipation, abdominal pain, and dizziness. […] Concerns with Pregnancy and Perinatal Infections: If a pregnant woman is infected with the Zika virus, it may result in microcephaly, a birth defect causing underdevelopment of the head and brain in newborn children. However, the link between ZIKV and infant microcephaly is poorly understood at this time.
  • #1 Zika Virus | Health | Province of Manitoba
    https://www.gov.mb.ca/health/publichealth/diseases/zika.html
    Most people do not develop symptoms and for those who do they are typically mild and may include fever, joint pain, rash and conjunctivitis (red eyes). Symptoms usually last from several days to a week. Severe symptoms requiring hospitalization are uncommon and fatalities are rare. […] Only 20% of infected individuals develop symptoms and these usually appear between 3 12 days after the bite of an infected mosquito. Common symptoms may include a low-grade fever, rash, muscle pain, short term joint pain, conjunctivitis (red eyes), eye pain, chills and headache. Less common non-specific symptoms may include weakness, lack of energy, sore throat, diarrhea and nausea/ vomiting. Symptoms are typically mild and last between 2 7 days. Severe disease requiring hospitalization is uncommon and deaths are rare. Most people recover fully from Zika virus infection. There is increasing evidence to support the observation that Zika virus infection is associated with neurological complications (i.e. Guillain-Barre syndrome) and birth defects (i.e. microcephaly).
  • #1
    https://dermnetnz.org/topics/zika-virus
    Zika virus causes an infection that is mainly spread by the bite of tropical zika virus-carrying mosquitoes. It presents as a flu-like illness rather similar to dengue fever, but not as severe. An itchy rash is a prominent feature. It also causes neurological symptoms due to small fibre neuropathy. […] Zika virus infection arises about 10 days after a bite from an infected mosquito. It results in headache, mild fever, chills, conjunctivitis (red eyes), joint and muscle aches and an itchy rash. Other non-specific symptoms may include headache, fatigue, malaise, abdominal pain and vomiting. […] Zika virus infection usually recovers within a week. […] The rash associated with zika virus is either morbilliform (papules) or scarlatiniform (micropapules). It starts on the face on the first day of illness and spreads to trunk and limbs. The rash may affect palms and soles, which may be swollen. It begins to fade within 2-3 days and is gone completely within a week. […] Dysaesthesia (numbness, tingling) may occur, as well as autonomic symptoms such as dry mouth, dry skin, dry eyes and bladder incontinence.
  • #1 Zika Virus: Causes, Symptoms, Treatment & Prevention
    https://my.clevelandclinic.org/health/diseases/16077-zika-virus
    Only about 1 in 5 people with Zika have symptoms, which include: Fever. Headache. Joint pain. Redness in the whites of your eyes (pink eye/conjunctivitis). Rash that’s a mix of raised and flat red areas of skin (maculopapular), which can be itchy. […] Zika is very serious for pregnant women because it can interfere with the fetus’s development. Zika is usually mild for most other adults and children. […] Symptoms usually last a few days to a week. […] If you’re pregnant and have Zika, it can cause congenital (present at birth) conditions in your baby, such as vision loss or improper brain development. These conditions are permanent. […] A small number of people with Zika (about 2 in 10,000) develop Guillain-Barr syndrome (GBS), an autoimmune disorder that can cause weakness and paralysis. Most people recover from GBS in a few weeks to a few months.
  • #1 Zika virus: An overview
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5290753/
    ZIKV infection in pregnant mothers can occur in any trimester and is reported to cause microcephaly in infants with many confirmed reports coming from Brazil showing the association of the virus infection with microcephaly in the newborn and even infant death (mostly if the infection is acquired during the first trimester). […] ZIKV infection acquired during pregnancy is associated with poor outcomes of the fetus, which includes central nervous system injury, placental insufficiency, in vitro fetal growth restriction (with or without microcephaly), and also fetal death. […] Few cases have been reported showing the association of ZIKV infection with the Guillain-Barr syndrome. […] About 90% of the patients had reported to have symptoms of ZIKV infection about 6 days prior to neurological symptoms.
  • #1 Zika Virus Infection | Encephalitis International
    https://www.encephalitis.info/types-of-encephalitis/infectious-encephalitis/zika-virus-infection/
    In most people, ZIKV infection causes a mild illness or may not cause any symptoms at all. The most common signs and symptoms of ZIKV infection are skin rash (mostly maculopapular- red bumps on a flat and red skin patch), fever, arthralgia (joints pain), myalgia (muscle pain), headache and conjunctivitis. Other symptoms such as articular oedema (joint swelling), sore throat, cough, and vomiting are also reported. […] ZIKV encephalitis symptoms range from disturbed level of consciousness, irritability, personality change and seizures to deep coma and death. […] The diagnosis can be made by clinical history, symptoms and laboratory tests looking for the virus or the antibody response to the virus in the blood and spinal fluid (which is collected from the lower back using a fine needle via a lumbar puncture). The virus can sometimes be detected in urine and saliva.
  • #1 Clinical Signs and Symptoms of Zika Virus Disease | Zika Virus | CDC
    https://www.cdc.gov/zika/hcp/clinical-signs/index.html
    Zika virus during pregnancy can cause a congenital infection with serious birth defects of the brain and eyes, including severe microcephaly, intracranial calcifications, cerebral or cortical atrophy, chorioretinal abnormalities, and optic nerve abnormalities. […] Infants with congenital Zika virus infection may appear asymptomatic at birth but have neuroimaging findings or clinical sequelae (e.g., vision loss) that is only detected after birth.
  • #1
    https://www.who.int/news-room/fact-sheets/detail/zika-virus
    Most people with Zika virus infection do not develop symptoms; those who do typically have symptoms including rash, fever, conjunctivitis, muscle and joint pain, malaise and headache that last for 27 days. […] Most people infected with Zika virus do not develop symptoms. Among those who do, they typically start 3-14 days after infection, are generally mild including rash, fever, conjunctivitis, muscle and joint pain, malaise and headache, and usually last for 27 days. These symptoms are common to other arboviral and non-arboviral diseases; thus, the diagnosis of Zika virus infection requires laboratory confirmation. […] Zika virus infection during pregnancy is a cause of microcephaly and other congenital malformations in the infant, including limb contractures, high muscle tone, eye abnormalities and hearing loss. These clinical features are collectively referred to as congenital Zika syndrome. […] Zika virus infection can also cause Guillain-Barr syndrome, neuropathy and myelitis, particularly in adults and older children.
  • #1 What is Zika? | Children’s National Hospital
    https://www.childrensnational.org/get-care/departments/zika-program/what-is-zika
    Zika virus infection is most commonly spread by mosquitoes and is circulating in such locations as South and Central America and Puerto Rico. Most people who are infected with Zika virus have no symptoms or, if they do have symptoms, they are very mild and can include the following: Fever, Rash, Red eyes, Muscle pains or joint pains. […] People usually do not get sick enough to be hospitalized and they very rarely die. A small number of people who are infected with Zika virus may later develop nerve weakness or paralysis called Guillain-Barre Syndrome. Again, most people with Guillain-Barre recover. […] Zika is especially problematic for women who are pregnant or who might become pregnant. There has been an association between Zika and microcephaly, a severe birth defect in which the size of the babys head and the brain volume is smaller than expected for their age. Zika infection also has been linked to birth defects that have long-term associated issues, including developmental delays such as: Delayed speech and motor milestones (sitting, standing, walking), Problems with movement and balance, Feeding problems, such as difficulty swallowing, Hearing loss, Vision problems.
  • #1 Frequently Asked Questions About Zika Virus | UCSF Health
    https://www.ucsfhealth.org/education/frequently-asked-questions-about-zika-virus
    The most recent research suggests that the rate of infection for a fetus may be between 1 and 13 percent if a pregnant woman is infected in the first trimester. Researchers currently believe it is less likely a fetus will become infected in the second and third trimesters, but more research is needed before this can be determined.
  • #1 Zika Virus Symptoms, Countries, Risk, and Prevention
    https://www.webmd.com/a-to-z-guides/zika-virus-symptoms-prevention
    Zika causes microcephaly in babies born to infected pregnant women, the CDC says. Microcephaly stunts a babys head growth, causing devastating, sometimes fatal brain damage, and it can result in miscarriage or stillbirth. […] Although there are many causes of microcephaly in babies, including infections during pregnancy, genetic problems, and exposure to toxic substances during pregnancy, the CDC says research has provided enough evidence to show that Zika is among those causes. […] Research has suggested that infection during the earliest stages of pregnancy, when a babys organs are still forming, seems to be linked to the worst outcomes. […] However, some studies are showing that fetuses can be harmed by infection later in pregnancy, and evidence is emerging that microcephaly isnt the only birth defect linked to Zika.
  • #1 Zika Virus: Causes, Symptoms, Treatment & Prevention
    https://my.clevelandclinic.org/health/diseases/16077-zika-virus
    If you’re pregnant and infected with Zika, the virus can also infect the fetus and interfere with its development. About 5% (1 in 20) of babies born to someone infected with Zika have congenital conditions, including: A smaller-than-average head (microcephaly). Microcephaly can mean your child’s brain didn’t develop properly. […] Theres no cure for Zika or the complications it can cause. Most people have mild symptoms and recover on their own.
  • #1 Zika Patient FAQ | Obstetrics, Gynecology & Reproductive Sciences
    https://obgyn.ucsf.edu/maternal-fetal-medicine/zika-virus-frequently-asked-questions-our-patients
    Adults who become infected with Zika may develop a rare neurological complication called Guillain-Barr syndrome. This is a condition that can cause temporary paralysis and may be severe enough to require extended time in the hospital with breathing support. Most people recover, but it can take several months for muscle function to be restored. […] If I test positive for Zika, what are the chances my fetus is infected and when will I know? There is a lot we do not know about why a fetus becomes infected with Zika virus and why others do not become infected. The most recent research suggests that the rate of infection for a fetus may be between 1% and 13 % if a pregnant woman is infected in the first trimester. It is believed it is less likely a fetus will become infected in the 2nd and 3rd trimesters, but more research is needed before this can be determined. There is not a specific gestational age at which a fetus shows Zika-related abnormalities. Sometimes the signs of infection do not appear until late in the 2nd trimester or 3rd trimester. Not all fetal abnormalities associated with Zika virus can be detected with an ultrasound examination.
  • #1 Open Search
    https://www.plannedparenthood.org/learn/pregnancy/zika
    Most people who get Zika have no symptoms or very mild symptoms. Symptoms may include fever, rash, joint/muscle pain, red eyes, or headache. Symptoms may last several days to a week. […] If you have Zika while you’re pregnant, it can cause: Miscarriage or stillbirth. Microcephaly or postnatal microcephaly, which is when a baby is born with, or within 6-12 months has, a very small head and brain. Developmental problems with vision, hearing, or growth, as well as brain development issues. […] You may or may not have any of these problems. There’s no way to know in advance whether Zika will affect your pregnancy or not. If you test positive for Zika during pregnancy, your doctor or nurse will check the pregnancy to look for any problems. Microcephaly is most easily found during ultrasounds in the late second/early third trimester of pregnancy, but could be found as early as 18-20 weeks.
  • #1 Symptoms | Zika in Texas
    https://www.texaszika.org/symptoms.htm
    Most people infected with Zika virus have few or no symptoms. If a person does have symptoms, they are usually mild and last several days to a week. Severe disease requiring hospitalization is uncommon, and fatalities are rare. […] Common symptoms include: Joint pain, Conjunctivitis (red eyes), Fever, Rash (often itchy). […] Zika virus may also cause Guillain-Barr syndrome, a condition in which your immune system attacks part of your nervous system.
  • #2
    https://www.gov.uk/guidance/zika-virus-symptoms-and-complications
    After an infected mosquito bites a human, the first symptoms of Zika can develop in 3 to 12 days but it can be shorter or longer in some people. […] The majority of people infected with Zika virus have no symptoms. For those with symptoms, Zika virus tends to cause a mild, short-lived (2 to 7 days) illness. […] Signs and symptoms suggestive of Zika virus infection may include a combination of the following: rash, itching or pruritus, fever, headache, arthralgia or arthritis, myalgia, conjunctivitis, lower back pain, retro-orbital pain. […] The symptoms of Zika are similar to dengue (caused by a related flavivirus) or chikungunya (an alphavirus), which are often co-circulating in areas where Zika virus is present. Laboratory testing is essential for the correct diagnosis.
  • #2 Zika Virus: Causes, Symptoms, Treatment & Prevention
    https://my.clevelandclinic.org/health/diseases/16077-zika-virus
    Only about 1 in 5 people with Zika have symptoms, which include: Fever. Headache. Joint pain. Redness in the whites of your eyes (pink eye/conjunctivitis). Rash that’s a mix of raised and flat red areas of skin (maculopapular), which can be itchy. […] Zika is very serious for pregnant women because it can interfere with the fetus’s development. Zika is usually mild for most other adults and children. […] Symptoms usually last a few days to a week. […] If you’re pregnant and have Zika, it can cause congenital (present at birth) conditions in your baby, such as vision loss or improper brain development. These conditions are permanent. […] A small number of people with Zika (about 2 in 10,000) develop Guillain-Barr syndrome (GBS), an autoimmune disorder that can cause weakness and paralysis. Most people recover from GBS in a few weeks to a few months.
  • #2 Clinical Signs and Symptoms of Zika Virus Disease | Zika Virus | CDC
    https://www.cdc.gov/zika/hcp/clinical-signs/index.html
    Approximately 80% of people infected with Zika virus are asymptomatic. […] Clinical illness is typically mild, characterized by fever, arthralgia, conjunctivitis, and maculopapular rash. […] Characteristic clinical findings associated with Zika virus disease are acute onset of fever with maculopapular rash, arthralgia, or nonpurulent conjunctivitis. Other commonly reported symptoms include myalgia and headache. Clinical illness is usually mild with symptoms lasting for several days to a week. […] Severe disease requiring hospitalization is uncommon and case fatality occurs in 1% of cases. However, cases of Guillain-Barr syndrome have occurred in patients following Zika virus infection. Rarely, encephalopathy, meningoencephalitis, myelitis, uveitis, and severe thrombocytopenia can occur.
  • #2 Zika virus: An overview
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5290753/
    Symptoms and signs of ZIKV infection occur only in about 20% cases infected with the majority of the patients being asymptomatic. […] The common symptoms are similar to those of DENV and chikungunya virus infections and include the acute onset of low-grade fever with maculopapular rash, arthralgia (involves the small joints of hands and feet), and conjunctivitis (non-purulent). […] Other symptoms include headache, retro-orbital pain, myalgia, asthenia, peripheral edema, and gastrointestinal disturbance (abdominal pain, nausea, diarrhea). […] Symptoms and signs typically occur approximately 2-12 days after the Aedes mosquito bite and usually resolve within 2-7 days. […] Postnatal ZIKV infection in infants and children present with similar signs and symptoms as that of adults. […] ZIKV infection has been associated with various complications, including congenital microcephaly, Guillain-Barr syndrome, and even fetal losses in women infected during pregnancy.
  • #2 Zika Virus – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK430981/
    An increase in cases of the acute Guillain-Barre syndrome (a type of acute paralytic neuropathy) was observed during the French Polynesia outbreak. Although not proven to be the cause, it is suspected that Zika virus infection is likely a trigger of Guillain-Barre syndrome. Cases of acute myelitis and meningoencephalitis have also been reported following Zika virus infection. […] Zika virus infection during pregnancy is the cause of a variety of congenital disabilities, including microcephaly and other brain abnormalities. […] Most cases of Zika virus infection are mild and resolve on their own. However, serious neurological disease has been reported including Guillain barre syndrome. In addition, there is great concern that the virus can induce congenital brain and eye malformations if acquired during pregnancy.
  • #2 Zika Virus: Signs, Symptoms, and Complications
    https://www.verywellhealth.com/zika-virus-symptoms-4047460
    The symptoms of GBS can persist for weeks and even months. […] While the Zika virus rarely causes serious illness in adults or children, the consequences of an infection can be far worse if transmitted during pregnancy. […] Particularly during the early stages of gestation, infection with Zika may cause a birth defect known as microcephaly, in which the baby is born with an abnormally small head and brain. […] Microcephaly can cause a cascade of physical, neurological, and developmental symptoms, including: Epilepsy, Developmental delays, including problems with speech and other developmental milestones such as sitting, standing, or walking, Intellectual disability, Cerebral palsy, Feeding problems, including difficulty swallowing (dysphagia), Hearing loss, Vision problems, including glaucoma, Impaired growth.
  • #2 Clinical Signs and Symptoms of Zika Virus Disease | Zika Virus | CDC
    https://www.cdc.gov/zika/hcp/clinical-signs/index.html
    Zika virus during pregnancy can cause a congenital infection with serious birth defects of the brain and eyes, including severe microcephaly, intracranial calcifications, cerebral or cortical atrophy, chorioretinal abnormalities, and optic nerve abnormalities. […] Infants with congenital Zika virus infection may appear asymptomatic at birth but have neuroimaging findings or clinical sequelae (e.g., vision loss) that is only detected after birth.
  • #2 Zika Virus: Causes, Symptoms, Treatment & Prevention
    https://my.clevelandclinic.org/health/diseases/16077-zika-virus
    If you’re pregnant and infected with Zika, the virus can also infect the fetus and interfere with its development. About 5% (1 in 20) of babies born to someone infected with Zika have congenital conditions, including: A smaller-than-average head (microcephaly). Microcephaly can mean your child’s brain didn’t develop properly. […] Theres no cure for Zika or the complications it can cause. Most people have mild symptoms and recover on their own.
  • #2 Infographics
    https://www.who.int/health-topics/zika-virus-disease
    Zika virus disease is primarily transmitted by the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti, in tropical and subtropical regions. The incubation period (the time from exposure to symptoms) of Zika virus disease is estimated to be 3 to 14 days. The majority of people infected with Zika virus do not develop symptoms. Symptoms are generally mild including fever, rash, conjunctivitis, muscle and joint pain, malaise, and headache, and usually last for 2 to 7 days. […] Zika virus infection during pregnancy is a cause of microcephaly and other congenital abnormalities in the developing fetus and newborn. Zika infection in pregnancy also results in pregnancy complications such as fetal loss, stillbirth, and preterm birth. […] Zika virus infection is also a trigger of Guillain-Barr syndrome, neuropathy and myelitis, particularly in adults and older children.
  • #2 Zika: : Symptoms, Prevention and Treatments – PAHO/WHO
    https://www.paho.org/en/topics/zika
    Diagnosis is based on clinical symptoms and epidemiological circumstances (such as Zika outbreak in the patient’s area or trips to areas where the virus is circulating). […] Zika does not have clearly characteristic features, but most patients have skin rashes and some have conjunctivitis. […] Treatment consists of relieving pain, fever, and any other symptom that inconveniences the patient. To prevent dehydration, it is recommended to control the fever, rest, and drink plenty of water. There is no vaccine or specific drug for this virus. […] In the past, Zika had very limited geographical and demographic distribution, and there was no evidence that it caused death. However, in the current outbreak in the Region of the Americas, cases have been reported of more serious manifestations and complications that have sometimes resulted in death.
  • #2 Zika virus – Canada.ca
    https://www.canada.ca/en/public-health/services/diseases/zika-virus.html
    Only 1 in 4 people infected with Zika virus develop symptoms. Symptoms often include: fever, headache, conjunctivitis (pink eye), skin rash, joint and muscle pain. It usually takes between 3 to 14 days for symptoms to appear after infection. The symptoms are usually mild and last for 2 to 7 days. […] Although most people recover with no complications, Zika virus infection in a pregnant woman can pose significant risks to the unborn baby, even if the woman does not develop any symptoms. Zika virus can cause serious birth defects including microcephaly (an abnormally small head), brain abnormalities, vision and hearing loss, and more. […] Symptoms are often mild and most people recover fully with no complications. […] Currently, there is no vaccine to prevent or medication to treat infection with Zika virus. Symptoms, when present, will typically resolve on their own within a few days. Treatment aims to relieve symptoms. You can relieve Zika virus symptoms by drinking fluids, getting rest, and taking acetaminophen (e.g. Tylenol) for fever and pain.
  • #3 Zika Virus – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK430981/
    Zika virus is a single-stranded RNA virus of the family and the genus Flavivirus. In the majority of people, infection by the Zika virus is mild and self-limiting. […] In most cases, Zika infection is a mild self-limited illness. Today, zika virus infection is a reportable illness. […] Most patients with acute Zika virus infections are either asymptomatic (60% to 80%) or have only mild symptoms. For Zika disease due to a mosquito bite, the estimated incubation phase between bite and symptoms is two to 14 days. In symptomatic infections, the most common symptoms/signs include: rash (90% or more), conjunctivitis (55% to 82%), fever (65% to 80%), and headache (45% to 80%). The rash is typically maculopapular, and the fever is often low grade, and short-lived. Other common symptoms and signs include arthralgia (65% to 70%, myalgia (48% to 65%), and retro-orbital pain (39% to 48%). Less commonly seen are edema, vomiting, and abdominal pain.
  • #3 Zika Virus: Causes, Symptoms, Treatment & Prevention
    https://my.clevelandclinic.org/health/diseases/16077-zika-virus
    Only about 1 in 5 people with Zika have symptoms, which include: Fever. Headache. Joint pain. Redness in the whites of your eyes (pink eye/conjunctivitis). Rash that’s a mix of raised and flat red areas of skin (maculopapular), which can be itchy. […] Zika is very serious for pregnant women because it can interfere with the fetus’s development. Zika is usually mild for most other adults and children. […] Symptoms usually last a few days to a week. […] If you’re pregnant and have Zika, it can cause congenital (present at birth) conditions in your baby, such as vision loss or improper brain development. These conditions are permanent. […] A small number of people with Zika (about 2 in 10,000) develop Guillain-Barr syndrome (GBS), an autoimmune disorder that can cause weakness and paralysis. Most people recover from GBS in a few weeks to a few months.
  • #3
    https://www.who.int/news-room/fact-sheets/detail/zika-virus
    Most people with Zika virus infection do not develop symptoms; those who do typically have symptoms including rash, fever, conjunctivitis, muscle and joint pain, malaise and headache that last for 27 days. […] Most people infected with Zika virus do not develop symptoms. Among those who do, they typically start 3-14 days after infection, are generally mild including rash, fever, conjunctivitis, muscle and joint pain, malaise and headache, and usually last for 27 days. These symptoms are common to other arboviral and non-arboviral diseases; thus, the diagnosis of Zika virus infection requires laboratory confirmation. […] Zika virus infection during pregnancy is a cause of microcephaly and other congenital malformations in the infant, including limb contractures, high muscle tone, eye abnormalities and hearing loss. These clinical features are collectively referred to as congenital Zika syndrome. […] Zika virus infection can also cause Guillain-Barr syndrome, neuropathy and myelitis, particularly in adults and older children.
  • #4 Zika virus – Wikipedia
    https://en.wikipedia.org/wiki/Zika_virus
    Zika fever (also known as Zika virus disease) is an illness caused by Zika virus. Around 80% of cases are estimated to be asymptomatic, though the accuracy of this figure is hindered by the wide variance in data quality, and figures from different outbreaks can vary significantly. Symptomatic cases are usually mild and can resemble dengue fever. Symptoms may include fever, red eyes, joint pain, headache, and a maculopapular rash. Symptoms generally last less than seven days. It has not caused any reported deaths during the initial infection. Infection during pregnancy causes microcephaly and other brain malformations in some babies. Infection in adults has been linked to GuillainBarr syndrome (GBS) and Zika virus has been shown to infect human Schwann cells. […] The infection, known as Zika fever or Zika virus disease, often causes no or only mild symptoms, similar to a very mild form of dengue fever.