Materiały źródłowe

• #1 Zika Virus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430981/

  Zika virus is a single-stranded RNA virus of the family and the genus Flavivirus. In the majority of people, infection by the Zika virus is mild and self-limiting. […] This activity reviews the evaluation and management of Zika virus and highlights the role of the interprofessional team in the recognition and management of this condition. […] Describe the recommended treatment of Zika virus. […] Treatment is supportive, encouraging rest, maintaining adequate hydration and the use of analgesics and antipyretics. If dengue fever is a possible etiology of the patients symptoms, aspirin and other nonsteroidal anti-inflammatory drugs should be avoided due to the hypothetical risk of hemorrhage and Reye syndrome. Individuals with Zika infection should be protected from mosquito exposure to reduce the risk of local transmission.

• #2 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #3 Treatment of Zika | Zika Virus | CDC

  https://www.cdc.gov/zika/treatment/index.html

  There are no medicines to treat Zika. […] However, the symptoms of Zika can be treated. […] Treating symptoms can include: […] Taking an over-the-counter medicine such as acetaminophen (Tylenol) to reduce fever and pain. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until dengue can be ruled out to reduce the risk of bleeding.

• #4 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #5 Treatment of Zika | Zika Virus | CDC

  https://www.cdc.gov/zika/treatment/index.html

  There are no medicines to treat Zika. […] However, the symptoms of Zika can be treated. […] Treating symptoms can include: […] Taking an over-the-counter medicine such as acetaminophen (Tylenol) to reduce fever and pain. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until dengue can be ruled out to reduce the risk of bleeding.

• #6

  https://www.who.int/news-room/fact-sheets/detail/zika-virus

  There is no specific treatment available for Zika virus infection or disease. […] People with symptoms such as rash, fever or joint pain should get plenty of rest, drink fluids, and treat symptoms with antipyretics and/or analgesics. Nonsteroidal anti-inflammatory drugs should be avoided until dengue virus infections are ruled out because of bleeding risk. If symptoms worsen, patients should seek medical care and advice. […] Pregnant women living in areas with Zika transmission or who develop symptoms of Zika virus infection should seek medical attention for laboratory testing, information, counselling and other clinical care.

• #7 Treatment of Zika | Zika Virus | CDC

  https://www.cdc.gov/zika/treatment/index.html

  There are no medicines to treat Zika. […] However, the symptoms of Zika can be treated. […] Treating symptoms can include: […] Taking an over-the-counter medicine such as acetaminophen (Tylenol) to reduce fever and pain. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until dengue can be ruled out to reduce the risk of bleeding.

• #8 Zika Virus Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/arboviruses-arenaviruses-filoviruses/zika-virus-infection

  There is no specific treatment for Zika virus infection, but rest, plenty of fluids, and acetaminophen to relieve fever and pain can help. […] Treatment of Zika virus infection is supportive. It includes the following: Rest, Fluids to prevent dehydration, Acetaminophen to relieve fever and pain. […] People who may have Zika virus infection should not take aspirin and or other nonsteroidal anti-inflammatory drugs (NSAIDs) until dengue has been ruled out. If people have dengue and take aspirin or another NSAID, the risk of excessive bleeding (hemorrhage) is increased. […] If the Zika virus is detected in pregnant women, doctors may recommend that ultrasonography be done every 3 to 4 weeks to monitor how the fetus is developing.

• #9 Treatment of Zika | Zika Virus | CDC

  https://www.cdc.gov/zika/treatment/index.html

  There are no medicines to treat Zika. […] However, the symptoms of Zika can be treated. […] Treating symptoms can include: […] Taking an over-the-counter medicine such as acetaminophen (Tylenol) to reduce fever and pain. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until dengue can be ruled out to reduce the risk of bleeding.

• #10 Zika Virus | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/z/zika-virus.html

  There is no medicine to cure the Zika virus. Treatment is aimed at easing symptoms. Rest and drinking plenty of fluids are helpful. Acetaminophen can help ease fever and pain. […] A pregnant person can pass the virus on to the unborn child, even without symptoms. The virus can cause a birth defect called microcephaly. […] There is no medicine to cure the Zika virus. Treatment is aimed at easing symptoms.

• #11 Zika Virus: Causes, Symptoms, Treatment, Vaccine, Pregnancy Risks

  https://www.medicinenet.com/zika_virus/article.htm

  Are there home remedies for Zika virus? Home remedies can help reduce the symptoms of the disease and are as follows: Fluids to prevent dehydration, Over-the-counter medications such as acetaminophen (Tylenol) can help reduce fever and pain, Rest, Diphenhydramine (Benadryl) or other antihistamines for itching, Avoid aspirin and nonsteroidal anti-inflammatory medications (NSAIDs) until dengue fever can be ruled out to reduce the chance of bleeding problems (do not use aspirin to treat children).

• #12 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Zika-treatment.aspx

  There is currently no specific vaccine to protect people against the Zika virus or any specific antiviral drug treatment for people who are infected with the virus already. Patients are advised to use medications that can help to alleviate the symptoms that they have. […] Patients who are suffering from fever may benefit from taking paracetamol to relieve the fever, headaches, joint pain or muscle pain that develops. Aspirin or non-steroidal anti-inflammatory drugs are not recommended for the condition. […] Patients should increase their intake of water, fruit juice or rehydration solutions to replace lost fluids. […] Artificial tear drops can help with any dryness that the patient feels in their eyes. The condition tends to improve when the virus clears the patients system.

• #13 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #14 Treatment of Zika | Zika Virus | CDC

  https://www.cdc.gov/zika/treatment/index.html

  There are no medicines to treat Zika. […] However, the symptoms of Zika can be treated. […] Treating symptoms can include: […] Taking an over-the-counter medicine such as acetaminophen (Tylenol) to reduce fever and pain. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until dengue can be ruled out to reduce the risk of bleeding.

• #15 Zika virus: Symptoms and treatment

  https://www.medicalnewstoday.com/articles/305163

  At present, there is no treatment for the virus. […] Currently, there is no treatment for Zika. […] A person with symptoms should: rest, increase fluid intake to prevent dehydration, take over-the-counter (OTC) pain killers to relieve pain and fever. […] The CDC advise against using aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until a diagnosis of dengue has been ruled out in those at risk due to the risk of hemorrhage. […] The CDC also advise that pregnant women who are diagnosed with Zika should be considered for the monitoring of fetal growth and anatomy program every 3 to 4 weeks. […] They also recommend seeing a doctor who specializes in pregnancy management and either infectious disease or maternal-fetal medicine.

• #16 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Zika virus (ZIKV) infection usually is mild and self-limited. There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. […] Supportive care with rest and adequate fluid hydration is advised. Symptoms such as fever and pain can be controlled with acetaminophen and pruritic rash with antihistamines. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. […] The WHO recommends optimal supportive care in patients with Guillain-Barr syndrome, including frequent neurologic examinations, testing of vital signs, and respiratory function monitoring to decrease the likelihood of complications (eg, blood clots, respiratory failure). Patients whose symptoms are escalating rapidly or who are unable to walk should receive intravenous immunoglobulin therapy or therapeutic plasma exchange.

• #17 Zika virus infection – including symptoms, treatment and prevention | SA Health

  https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/conditions/infectious+diseases/zika+virus+infection/zika+virus+infection+-+including+symptoms+treatment+and+prevention

  Zika virus infection is a notifiable condition1 […] Treatment for Zika virus infection […] There is no specific treatment available. General recommendations include the use of supportive treatments such as rest, fluids and medications for pain relief. […] Do not use aspirin or other non-steroidal anti-inflammatory medications until dengue fever is excluded. These medications can cause severe bleeding in people with dengue fever. […] Aspirin should not be given to children under 12 years of age unless specifically recommended by a doctor.

• #18 Zika virus treatment

  https://www.mymed.com/diseases-conditions/zika-virus/zika-virus-treatment

  Currently, there is no specific antiviral treatment plan for Zika virus infections, nor has a vaccine yet been developed. Doctors thus typically treat the set of active virus symptoms presented during consultation and testing. […] As the symptoms are typically flu-like in nature, doctors will recommend the following: Plenty of rest, Plenty of fluid-intake (water, broths and juices will help to prevent dehydration), The taking of over-the-counter medications, such as acetaminophen or ibuprofen to reduce fever, aches and pains. […] Treatment recommendations will take into consideration any other medications and supplements (including herbal products) already being taken, so as to avoid adverse drug interactions. If it is determined during the initial consultation that aspirin or NSAIDS (non-steroidal anti-inflammatory medications) were used to treat symptoms before a specific viral infection was diagnosed, a doctor will have requested immediate discontinuation. Until dengue fever is ruled out, none of these medication types will be safe to take as they can lead to internal bleeding (haemorrhage). […] Symptoms of Zika virus should clear within a week (approximately 7 days).

• #19 Zika virus | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/zika-virus

  Zika virus disease is usually relatively mild. […] Currently, there is no cure or specific treatment for Zika virus. Treatment aims to ease symptoms and reduce the risk of complications while the person recovers. […] People diagnosed with Zika virus infection should: get plenty of rest, drink enough fluids, treat pain and fever with common medicines such as paracetamol. […] Do not take aspirin or other non-steroidal anti-inflammatory drugs (such as ibuprofen) unless advised by your doctor. […] If you have visited a country with active Zika virus transmission and have symptoms that could be caused by Zika infection, you should seek medical care and advice, especially as there could be other causes of your symptoms. […] If symptoms worsen, seek further medical care and advice.

• #20 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #21

  https://www.who.int/news-room/fact-sheets/detail/zika-virus

  There is no specific treatment available for Zika virus infection or disease. […] People with symptoms such as rash, fever or joint pain should get plenty of rest, drink fluids, and treat symptoms with antipyretics and/or analgesics. Nonsteroidal anti-inflammatory drugs should be avoided until dengue virus infections are ruled out because of bleeding risk. If symptoms worsen, patients should seek medical care and advice. […] Pregnant women living in areas with Zika transmission or who develop symptoms of Zika virus infection should seek medical attention for laboratory testing, information, counselling and other clinical care.

• #22 Zika Virus Prevention and Treatment Recommendations – Canada.ca

  https://www.canada.ca/en/public-health/services/publications/diseases-conditions/zika-virus-prevention-treatment-recommendations.html

  Currently there is no specific therapy for the treatment of ZIKV infection. Treatment is supportive with antipyretics (acetaminophen in pregnancy), hydration and rest. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. Symptomatic disease typically lasts for up to 7 days. Urgent medical care is recommended for any symptoms associated with GBS, and treating health care providers should be made aware of recent travel to area with ZIKV circulation and/or symptoms of ZIKV infection. […] If ZIKV infection is confirmed in the setting of pregnancy, referral to a Maternal Fetal Medicine Specialist or specialist familiar with Reproductive Infectious Diseases should be made. If microcephaly, intracranial calcifications or other abnormalities are identified, appropriate counselling by a Neonatologist and Pediatric Infectious Diseases Specialist on potential neurodevelopmental outcome should be offered to parents.

• #23 Zika virus: Symptoms and treatment

  https://www.medicalnewstoday.com/articles/305163

  At present, there is no treatment for the virus. […] Currently, there is no treatment for Zika. […] A person with symptoms should: rest, increase fluid intake to prevent dehydration, take over-the-counter (OTC) pain killers to relieve pain and fever. […] The CDC advise against using aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until a diagnosis of dengue has been ruled out in those at risk due to the risk of hemorrhage. […] The CDC also advise that pregnant women who are diagnosed with Zika should be considered for the monitoring of fetal growth and anatomy program every 3 to 4 weeks. […] They also recommend seeing a doctor who specializes in pregnancy management and either infectious disease or maternal-fetal medicine.

• #24 Zika virus

  https://www.nhs.uk/conditions/zika/

  There are no specific treatments for Zika virus. […] If you have symptoms, you should: get plenty of rest, drink lots of fluids, take pain relief, such as paracetamol. […] If you’re pregnant and have Zika virus, your midwife or hospital doctor will talk about the risk with you and may arrange an ultrasound scan to check your baby’s growth. […] You may also be referred to a specialist for more monitoring.

• #25 Zika Virus Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/arboviruses-arenaviruses-filoviruses/zika-virus-infection

  There is no specific treatment for Zika virus infection, but rest, plenty of fluids, and acetaminophen to relieve fever and pain can help. […] Treatment of Zika virus infection is supportive. It includes the following: Rest, Fluids to prevent dehydration, Acetaminophen to relieve fever and pain. […] People who may have Zika virus infection should not take aspirin and or other nonsteroidal anti-inflammatory drugs (NSAIDs) until dengue has been ruled out. If people have dengue and take aspirin or another NSAID, the risk of excessive bleeding (hemorrhage) is increased. […] If the Zika virus is detected in pregnant women, doctors may recommend that ultrasonography be done every 3 to 4 weeks to monitor how the fetus is developing.

• #26 Zika virus: Symptoms and treatment

  https://www.medicalnewstoday.com/articles/305163

  At present, there is no treatment for the virus. […] Currently, there is no treatment for Zika. […] A person with symptoms should: rest, increase fluid intake to prevent dehydration, take over-the-counter (OTC) pain killers to relieve pain and fever. […] The CDC advise against using aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) until a diagnosis of dengue has been ruled out in those at risk due to the risk of hemorrhage. […] The CDC also advise that pregnant women who are diagnosed with Zika should be considered for the monitoring of fetal growth and anatomy program every 3 to 4 weeks. […] They also recommend seeing a doctor who specializes in pregnancy management and either infectious disease or maternal-fetal medicine.

• #27 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #28 Zika Virus Prevention and Treatment Recommendations – Canada.ca

  https://www.canada.ca/en/public-health/services/publications/diseases-conditions/zika-virus-prevention-treatment-recommendations.html

  Currently there is no specific therapy for the treatment of ZIKV infection. Treatment is supportive with antipyretics (acetaminophen in pregnancy), hydration and rest. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. Symptomatic disease typically lasts for up to 7 days. Urgent medical care is recommended for any symptoms associated with GBS, and treating health care providers should be made aware of recent travel to area with ZIKV circulation and/or symptoms of ZIKV infection. […] If ZIKV infection is confirmed in the setting of pregnancy, referral to a Maternal Fetal Medicine Specialist or specialist familiar with Reproductive Infectious Diseases should be made. If microcephaly, intracranial calcifications or other abnormalities are identified, appropriate counselling by a Neonatologist and Pediatric Infectious Diseases Specialist on potential neurodevelopmental outcome should be offered to parents.

• #29 Zika Virus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430981/

  Currently, there is no treatment for Zika virus complicating pregnancy. Prevention is key. Pregnant women should avoid mosquito exposure, and avoid travel to known Zika virus areas, if possible. If unable to avoid exposure, testing, as described above, is recommended. If planning to become pregnant, the woman should avoid conception (abstinence or use of condoms) for at least 8 weeks after exposure or the start of symptoms. Men should avoid the risk of their partner conceiving (abstinence or use of condoms) for at least six months after exposure or initial symptoms. […] The Zika virus has recently emerged as a new mosquito-borne viral infection. While in most people the virus causes a harmless infection, there are many reports indicating that the virus can cause both neurological and eye problems. In addition, Pregnant women are at very high risk for delivering an infant with microcephaly. The virus is also known to be transmitted sexually. There is no cure for the Zika virus, and thus prevention is the key.

• #30 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Zika virus (ZIKV) infection usually is mild and self-limited. There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. […] Supportive care with rest and adequate fluid hydration is advised. Symptoms such as fever and pain can be controlled with acetaminophen and pruritic rash with antihistamines. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. […] The WHO recommends optimal supportive care in patients with Guillain-Barr syndrome, including frequent neurologic examinations, testing of vital signs, and respiratory function monitoring to decrease the likelihood of complications (eg, blood clots, respiratory failure). Patients whose symptoms are escalating rapidly or who are unable to walk should receive intravenous immunoglobulin therapy or therapeutic plasma exchange.

• #31 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Zika virus (ZIKV) infection usually is mild and self-limited. There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. […] Supportive care with rest and adequate fluid hydration is advised. Symptoms such as fever and pain can be controlled with acetaminophen and pruritic rash with antihistamines. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. […] The WHO recommends optimal supportive care in patients with Guillain-Barr syndrome, including frequent neurologic examinations, testing of vital signs, and respiratory function monitoring to decrease the likelihood of complications (eg, blood clots, respiratory failure). Patients whose symptoms are escalating rapidly or who are unable to walk should receive intravenous immunoglobulin therapy or therapeutic plasma exchange.

• #32 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Zika virus (ZIKV) infection usually is mild and self-limited. There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. […] Supportive care with rest and adequate fluid hydration is advised. Symptoms such as fever and pain can be controlled with acetaminophen and pruritic rash with antihistamines. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. […] The WHO recommends optimal supportive care in patients with Guillain-Barr syndrome, including frequent neurologic examinations, testing of vital signs, and respiratory function monitoring to decrease the likelihood of complications (eg, blood clots, respiratory failure). Patients whose symptoms are escalating rapidly or who are unable to walk should receive intravenous immunoglobulin therapy or therapeutic plasma exchange.

• #33 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Zika virus (ZIKV) infection usually is mild and self-limited. There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. […] Supportive care with rest and adequate fluid hydration is advised. Symptoms such as fever and pain can be controlled with acetaminophen and pruritic rash with antihistamines. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. […] The WHO recommends optimal supportive care in patients with Guillain-Barr syndrome, including frequent neurologic examinations, testing of vital signs, and respiratory function monitoring to decrease the likelihood of complications (eg, blood clots, respiratory failure). Patients whose symptoms are escalating rapidly or who are unable to walk should receive intravenous immunoglobulin therapy or therapeutic plasma exchange.

• #34 Zika Virus Infection | Encephalitis International

  https://www.encephalitis.info/types-of-encephalitis/infectious-encephalitis/zika-virus-infection/

  At the moment there is no specific treatment for ZIKV infection. Treatment is symptomatic, including antipyretic (to reduce fever), analgesic (to reduce pain), anti-inflammatory drugs (to reduce joint and muscle pain), lubricating eye drops if required, anti-allergy drugs (for itching), among others. […] There is no specific treatment for ZIKV encephalitis. Usually, it consists of treating the complications of encephalitis such as aches, seizures or raised pressure within the skull. […] The outcome is extremely variable: people can recover completely or remain with deficits. The outcome of ZIKV encephalitis is difficult to assess as only a few cases have been reported. In children who had been infected during pregnancy, the prognosis is usually poor, with cognitive deficits and a psychomotor development delay.

• #35 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #36 A screen of FDA-approved drugs for inhibitors of Zika virus infection

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4993926/

  Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus (ZIKV) infection. […] To address the immediate need for anti-ZIKV therapy we interrogated a library of FDA-approved drugs for the ability to block ZIKV infection. Our work identified more than 20 therapeutics that decreased ZIKV infection in HuH-7 cells. […] This study identifies drugs that could be immediately tested by clinical experts for ZIKV infection during pregnancy or in the context of severe ZIKV. […] Here we identified FDA-approved drugs that can inhibit ZIKV infection in several human cells, including those of genitourinary and neural origin and suggest that these drugs be carefully considered for expedited trials among Zika patients. […] It is critically important to note that many of the drugs shown to have anti-ZIKV activity could have untoward effects, particularly in the context of pregnancy, and therefore their use should be only in the hands of clinical experts, preferably under research protocols.

• #37 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #38 A treatment for Zika virus infection and neuroprotection efficacy – CIRM

  https://www.cirm.ca.gov/our-progress/awards/treatment-zika-virus-infection-and-neuroprotection-efficacy/

  We have successfully found approved drugs to block Zika virus replication and infection. […] We propose to determine the impact of the Zika virus during human neurodevelopment and to test a FDA-approved therapeutic candidate to treat Zika infection. […] A drug to treat/cure Zika infection and for neuroprotection. […] To re-purpose a therapeutic drug to treat Zika infection and for neuroprotection using in vivo models. […] This proposal will test a FDA-approved drug repurposed to neutralize the virus deleterious consequences in human brain cells. […] Sci Rep (2017): Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.

• #39 Malaria drug protects fetuses from Zika infection – WashU Medicine

  https://medicine.washu.edu/news/malaria-drug-protects-fetuses-from-zika-infection/

  Treatment prevents virus from crossing placenta to infect fetus, mouse study shows […] Moreover, they showed that a malaria drug that interferes with this process protects the fetus from viral infection. […] We found that the malaria drug hydroxychloroquine effectively blocks viral transmission to the fetus, said senior author Indira Mysorekar, PhD, an associate professor of obstetrics and gynecology, and of pathology and immunology. […] This drug already is used in pregnant women to treat malaria, and we suggest that it warrants evaluation in primates and women to diminish the risks of Zika infection and disease in developing fetuses. […] Following treatment, the researchers found significantly less virus in the fetuses and placentas from the mice that had received hydroxychloroquine. […] Our study suggests that an autophagy-based therapeutic intervention against Zika may be warranted in pregnant women infected with Zika virus.

• #40 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #41

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  Further investigation into the mechanism of action and efficacy in a Zika animal model appears warranted; niclosamide displayed no risk to fetuses in animal studies, is orally available, causes minimal side effects in humans, and is recommended by the World Health Organization for treatment of pregnant women with intestinal tapeworm infections. […] Collectively, the reported data may suggest that sofosbuvir should be investigated in additional animal models and potentially in a clinical trial; however, the price of sofosbuvir could be prohibitive.

• #42 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #43 A Review of the Ongoing Research on Zika Virus Treatment

  https://www.mdpi.com/1999-4915/10/5/255

  In the search for effective antivirals, research centers have screened compounds which previously demonstrated to possess antiviral activity against other pathogens for their therapeutical potential against ZIKV infection. […] Some molecules, such as niclosamide, emricasan, ivermectin, MPA, and daptomycin, have shown to be effective on ZIKV infection in vitro by inhibiting viral entry into the cells and/or replication, or by decreasing cell death induced by infection. Natural compounds, synthetic compounds, and nucleoside analogs have been the subject of research in the search for new molecules that inhibit the infection caused by ZIKV, and some studies have demonstrated the therapeutic potential of these different approaches.

• #44 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #45

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  Although antigenic variability between different strains, and even within the same strain, of ZIKV may pose as a drug design hurdle, some noteworthy inhibitors of viral attachment, entry, and fusion have surfaced. […] Antiviral activity against ZIKV was explored in vitro and in vivo for natural oxysterol, 25-hydroxycholesterol (25HC). […] Suramin is an FDA-approved antiparasitic with antiviral activity against flaviviruses. […] The NS2BNS3 protease is well conserved across the genus and no mutations have been acquired in the ZIKV protease sequence since 1967, making it a prime viral target. […] Several studies aimed at identifying inhibitors of the ZIKV protease have been initiated with moderate success. […] The potential for confounding effects introduced by the artificial linker has spurred the study of alternative constructs.

• #46 Researchers discover HIV drug is effective against Zika virus | Temple Now

  https://news.temple.edu/news/2019-11-01/researchers-discover-hiv-drug-effective-against-zika-virus

  A research team at Temple’s Lewis Katz School of Medicine has discovered that a drug used to treat HIV is effective in suppressing Zika virus, suggesting potential global implications for treating mosquito-borne viral diseases. […] A team of Temple researchers has discovered that a drug used for HIV treatment is also effective in suppressing Zika virus. […] In a new study published in the journal Molecular Therapy, the research team—led by Laura H. Carnell Professor and Department of Neuroscience Chair Kamel Khalili, director of the Center for Neurovirology and the Comprehensive NeuroAIDS Center at the Lewis Katz School of Medicine—describes a study that demonstrated in cell and animal models that the drug, rilpivirine, stops Zika virus by targeting enzymes that both Zika and HIV depend on for replication.

• #47 Researchers discover HIV drug is effective against Zika virus | Temple Now

  https://news.temple.edu/news/2019-11-01/researchers-discover-hiv-drug-effective-against-zika-virus

  This research breakthrough and other tests showing that other NNRTIs are effective in Zika-infected cells have significant implications for their use in treating other flavivirus infections. […] The researchers plan to soon step up their studies to develop ways to improve the effectiveness of these drugs in blocking viral infections. […] “We now have a clear path forward,” Khalili said. “We have a starting point from which we can find ways to make these drugs even more potent and more effective against flaviviruses.”

• #48

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  The rational design of RdRp active site and allosteric inhibitors is possible now that several crystal structures of the ZIKV NS5 protein have been reported. […] The most potent flavivirus helicase inhibitor, the benzoxazole ST-610, was not identified using an assay for helicase activity. […] The addition of a cap structure to the 5 end of most ssRNA is essential for its stability, splicing, transport, and translation. […] Prior to the publication of crystal structures of the ZIKV methyltransferase domain, an effort to identify inhibitors was undertaken using molecular modeling. […] Owing to the urgent need for therapies that can be quickly translated to the clinic, several laboratories have investigated repurposing existing drugs or drug candidates. […] The most promising compound identified from this screen, for potential use in pregnant patients, was niclosamide.

• #49

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  Although antigenic variability between different strains, and even within the same strain, of ZIKV may pose as a drug design hurdle, some noteworthy inhibitors of viral attachment, entry, and fusion have surfaced. […] Antiviral activity against ZIKV was explored in vitro and in vivo for natural oxysterol, 25-hydroxycholesterol (25HC). […] Suramin is an FDA-approved antiparasitic with antiviral activity against flaviviruses. […] The NS2BNS3 protease is well conserved across the genus and no mutations have been acquired in the ZIKV protease sequence since 1967, making it a prime viral target. […] Several studies aimed at identifying inhibitors of the ZIKV protease have been initiated with moderate success. […] The potential for confounding effects introduced by the artificial linker has spurred the study of alternative constructs.

• #50

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  The rational design of RdRp active site and allosteric inhibitors is possible now that several crystal structures of the ZIKV NS5 protein have been reported. […] The most potent flavivirus helicase inhibitor, the benzoxazole ST-610, was not identified using an assay for helicase activity. […] The addition of a cap structure to the 5 end of most ssRNA is essential for its stability, splicing, transport, and translation. […] Prior to the publication of crystal structures of the ZIKV methyltransferase domain, an effort to identify inhibitors was undertaken using molecular modeling. […] Owing to the urgent need for therapies that can be quickly translated to the clinic, several laboratories have investigated repurposing existing drugs or drug candidates. […] The most promising compound identified from this screen, for potential use in pregnant patients, was niclosamide.

• #51

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  The rational design of RdRp active site and allosteric inhibitors is possible now that several crystal structures of the ZIKV NS5 protein have been reported. […] The most potent flavivirus helicase inhibitor, the benzoxazole ST-610, was not identified using an assay for helicase activity. […] The addition of a cap structure to the 5 end of most ssRNA is essential for its stability, splicing, transport, and translation. […] Prior to the publication of crystal structures of the ZIKV methyltransferase domain, an effort to identify inhibitors was undertaken using molecular modeling. […] Owing to the urgent need for therapies that can be quickly translated to the clinic, several laboratories have investigated repurposing existing drugs or drug candidates. […] The most promising compound identified from this screen, for potential use in pregnant patients, was niclosamide.

• #52

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  The rational design of RdRp active site and allosteric inhibitors is possible now that several crystal structures of the ZIKV NS5 protein have been reported. […] The most potent flavivirus helicase inhibitor, the benzoxazole ST-610, was not identified using an assay for helicase activity. […] The addition of a cap structure to the 5 end of most ssRNA is essential for its stability, splicing, transport, and translation. […] Prior to the publication of crystal structures of the ZIKV methyltransferase domain, an effort to identify inhibitors was undertaken using molecular modeling. […] Owing to the urgent need for therapies that can be quickly translated to the clinic, several laboratories have investigated repurposing existing drugs or drug candidates. […] The most promising compound identified from this screen, for potential use in pregnant patients, was niclosamide.

• #53 Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide | Nature Materials

  https://www.nature.com/articles/s41563-018-0194-2

  Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including GuillainBarr syndrome and congenital Zika syndrome. As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. We evaluated the therapeutic efficacy of the peptide in a lethal Zika virus mouse model exhibiting systemic and brain infection. Therapeutic treatment protected against mortality and markedly reduced clinical symptoms, viral loads and neuroinflammation, as well as mitigated microgliosis, neurodegeneration and brain damage. […] In addition to controlling systemic infection, the peptide crossed the bloodbrain barrier to reduce viral loads in the brain and protected against Zika-virus-induced bloodbrain barrier injury. Our findings demonstrate how engineering strategies can be applied to develop peptide therapeutics and support the potential of a brain-penetrating peptide to treat neurotropic viral infections.

• #54

  https://research.wayne.edu/news/wayne-state-university-researchers-uncover-potential-treatment-targets-for-zika-virus-related-eye-abnormalities-61920

  Wayne State University researchers uncover potential treatment targets for Zika virus-related eye abnormalities. Groundbreaking research led by Professor Ashok Kumar and Postdoctoral Fellow Sneha Singh is offering promising opportunities for therapeutic interventions for Zika virus-related eye abnormalities. A groundbreaking study published in the journal iScience presents crucial insights into the ocular effects of Zika virus infection during pregnancy and offers promising avenues for therapeutic intervention. Despite the ZIKV infection causing severe neurological and ocular abnormalities in infants, no specific vaccines or antiviral treatments are available. Our study aimed to uncover the molecular mechanisms underlying ZIKV-related eye abnormalities, with a focus on cellular metabolism. By elucidating the roles of key players in cholesterol metabolism, we sought to identify potential targets for therapeutic intervention. In vivo studies using mouse models of ZIKV-induced chorioretinal lesions revealed that treatment with an LXR agonist or SREBP-2 inhibitor mitigated ocular abnormalities associated with ZIKV infection. Our findings suggest that targeting cholesterol pathway components, such as ABCG1 and SREBP-2, could offer promising therapeutic strategies for mitigating ZIKV-induced ocular complications. Through the innovative research team that Dr. Kumar has established, they are at the forefront of developing breakthroughs that will play a vital role in therapeutic interventions in eye abnormalities caused by the Zika virus.

• #55 Researchers uncover potential treatment targets for Zika virus–related eye abnormalities

  https://medicalxpress.com/news/2024-03-uncover-potential-treatment-zika-virusrelated.html

  A study published in the journal iScience presents crucial insights into the ocular effects of Zika virus infection during pregnancy and offers promising avenues for therapeutic intervention. […] Despite the ZIKV infection causing severe neurological and ocular abnormalities in infants, no specific vaccines or antiviral treatments are available. […] By elucidating the roles of key players in cholesterol metabolism, we sought to identify potential targets for therapeutic intervention. […] In vivo studies using mouse models of ZIKV-induced chorioretinal lesions revealed that treatment with an LXR agonist or SREBP-2 inhibitor mitigated ocular abnormalities associated with ZIKV infection. […] Our findings suggest that targeting cholesterol pathway components, such as ABCG1 and SREBP-2, could offer promising therapeutic strategies for mitigating ZIKV-induced ocular complications.

• #56 Zika Virus | FDA

  https://www.fda.gov/emergency-preparedness-and-response/mcm-issues/zika-virus

  There are no FDA-approved vaccines for Zika virus. Several investigational vaccines are under development, including early human clinical trials. […] There are no FDA-approved treatments for Zika virus, nor is the FDA aware of treatments in advanced development for Zika at this time.

• #57 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  While no specific treatment exists, paracetamol (acetaminophen) and rest may help with the symptoms. […] Treatment of Zika includes getting plenty of rest, drinking a lot of fluids to stay hydrated, and over-the-counter medicines such as acetaminophen to relieve fever and pain. It is not recommended to take aspirin or other non-steroidal anti-inflammatory drugs until after dengue infection is ruled out. […] The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines, which are safe to use in pregnant women. […] As of March 2016, 18 companies and institutions were developing vaccines against Zika, but they state a vaccine is unlikely to be widely available for about 10 years. […] In June 2016, the FDA granted the first approval for a human clinical trial for a Zika vaccine.

• #58 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  While no specific treatment exists, paracetamol (acetaminophen) and rest may help with the symptoms. […] Treatment of Zika includes getting plenty of rest, drinking a lot of fluids to stay hydrated, and over-the-counter medicines such as acetaminophen to relieve fever and pain. It is not recommended to take aspirin or other non-steroidal anti-inflammatory drugs until after dengue infection is ruled out. […] The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines, which are safe to use in pregnant women. […] As of March 2016, 18 companies and institutions were developing vaccines against Zika, but they state a vaccine is unlikely to be widely available for about 10 years. […] In June 2016, the FDA granted the first approval for a human clinical trial for a Zika vaccine.

• #59 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection. […] As of April 2017, both subunit and inactivated vaccines have entered clinical trials. However, like vaccines for other arboviruses, it is difficult to counteract an epidemic of this virus due to how it can appear sporadically and unpredictably.

• #60 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection. […] As of April 2017, both subunit and inactivated vaccines have entered clinical trials. However, like vaccines for other arboviruses, it is difficult to counteract an epidemic of this virus due to how it can appear sporadically and unpredictably.

• #61 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection. […] As of April 2017, both subunit and inactivated vaccines have entered clinical trials. However, like vaccines for other arboviruses, it is difficult to counteract an epidemic of this virus due to how it can appear sporadically and unpredictably.

• #62 Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04930-4

  Zika virus (ZIKV), a member of the flavivirus virus family, is one such virus candidate that is in the stage of early experimental development. […] ZIKV-LAV strains productively infected and lysed human GBM cells but not primary endothelia and terminally differentiated neurons. […] ZIKV-LAV infection in human GBM cells leads to both apoptotic and lytic cell death pathwaysparticularly pyroptosisduring late infection. […] ZIKV-LAV strains, particularly DN-1, exhibited potent oncolytic activity in human glioblastoma multiforme (GBM) cells without productively infecting non-cancer cells, such as terminally differentiated human neurons and primary endothelia. […] The reduced neurotropism also enhances cancer selectivity of ZIKV-LAV and, consequently, affords wider therapeutic window compared to wild-type ZIKV.

• #63 Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04930-4

  Zika virus (ZIKV), a member of the flavivirus virus family, is one such virus candidate that is in the stage of early experimental development. […] ZIKV-LAV strains productively infected and lysed human GBM cells but not primary endothelia and terminally differentiated neurons. […] ZIKV-LAV infection in human GBM cells leads to both apoptotic and lytic cell death pathwaysparticularly pyroptosisduring late infection. […] ZIKV-LAV strains, particularly DN-1, exhibited potent oncolytic activity in human glioblastoma multiforme (GBM) cells without productively infecting non-cancer cells, such as terminally differentiated human neurons and primary endothelia. […] The reduced neurotropism also enhances cancer selectivity of ZIKV-LAV and, consequently, affords wider therapeutic window compared to wild-type ZIKV.

• #64 Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04930-4

  Zika virus (ZIKV), a member of the flavivirus virus family, is one such virus candidate that is in the stage of early experimental development. […] ZIKV-LAV strains productively infected and lysed human GBM cells but not primary endothelia and terminally differentiated neurons. […] ZIKV-LAV infection in human GBM cells leads to both apoptotic and lytic cell death pathwaysparticularly pyroptosisduring late infection. […] ZIKV-LAV strains, particularly DN-1, exhibited potent oncolytic activity in human glioblastoma multiforme (GBM) cells without productively infecting non-cancer cells, such as terminally differentiated human neurons and primary endothelia. […] The reduced neurotropism also enhances cancer selectivity of ZIKV-LAV and, consequently, affords wider therapeutic window compared to wild-type ZIKV.

• #65 Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04930-4

  Zika virus (ZIKV), a member of the flavivirus virus family, is one such virus candidate that is in the stage of early experimental development. […] ZIKV-LAV strains productively infected and lysed human GBM cells but not primary endothelia and terminally differentiated neurons. […] ZIKV-LAV infection in human GBM cells leads to both apoptotic and lytic cell death pathwaysparticularly pyroptosisduring late infection. […] ZIKV-LAV strains, particularly DN-1, exhibited potent oncolytic activity in human glioblastoma multiforme (GBM) cells without productively infecting non-cancer cells, such as terminally differentiated human neurons and primary endothelia. […] The reduced neurotropism also enhances cancer selectivity of ZIKV-LAV and, consequently, affords wider therapeutic window compared to wild-type ZIKV.

• #66 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumours with Zika virus shrank or eliminated those tumours in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumour size. […] The highest dosage tested resulted in complete elimination of the tumour.

• #67 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice

  https://medicalxpress.com/news/2024-01-zika-virus-effective-childhood-cancer.html

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumors with Zika virus shrank or eliminated those tumors in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy, according to a study led by Nemours Children’s Health researchers and published in Cancer Research Communications. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumor size.

• #68 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumours with Zika virus shrank or eliminated those tumours in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumour size. […] The highest dosage tested resulted in complete elimination of the tumour.

• #69 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice

  https://medicalxpress.com/news/2024-01-zika-virus-effective-childhood-cancer.html

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumors with Zika virus shrank or eliminated those tumors in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy, according to a study led by Nemours Children’s Health researchers and published in Cancer Research Communications. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumor size.

• #70 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumours with Zika virus shrank or eliminated those tumours in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumour size. […] The highest dosage tested resulted in complete elimination of the tumour.

• #71 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  After four additional weeks, no further tumour growth was detected, suggesting that patients treated with Zika virus would be more likely to survive. […] The researchers cautioned that the use of Zika virus as a cancer therapy will require extensive additional studies encompassing safety and efficacy. […] With further validation, Zika virus could be an extremely effective bridge therapy for patients with high-risk neuroblastoma. […] We also see potential for Zika virus to be used to treat children and adults with other cancers that express high levels of CD24.

• #72 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice

  https://medicalxpress.com/news/2024-01-zika-virus-effective-childhood-cancer.html

  Furthermore, the mice did not develop any symptoms of Zika virus infection or any side effects. […] The researchers cautioned that the use of Zika virus as a cancer therapy will require extensive additional studies encompassing safety and efficacy. […] „With further validation, Zika virus could be an extremely effective bridge therapy for patients with high-risk neuroblastoma,” said Mazar. […] „Neuroblastoma is often a very challenging diagnosis, especially for the patients who are unlikely to respond well to chemotherapy,” said Matthew M. Davis, MD, MAPP, Executive Vice-President, Enterprise Physician-in-Chief and Chief Scientific Officer of Nemours.

• #73 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumours with Zika virus shrank or eliminated those tumours in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumour size. […] The highest dosage tested resulted in complete elimination of the tumour.

• #74 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice

  https://medicalxpress.com/news/2024-01-zika-virus-effective-childhood-cancer.html

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumors with Zika virus shrank or eliminated those tumors in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy, according to a study led by Nemours Children’s Health researchers and published in Cancer Research Communications. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumor size.

• #75 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  After four additional weeks, no further tumour growth was detected, suggesting that patients treated with Zika virus would be more likely to survive. […] The researchers cautioned that the use of Zika virus as a cancer therapy will require extensive additional studies encompassing safety and efficacy. […] With further validation, Zika virus could be an extremely effective bridge therapy for patients with high-risk neuroblastoma. […] We also see potential for Zika virus to be used to treat children and adults with other cancers that express high levels of CD24.

• #76 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice

  https://medicalxpress.com/news/2024-01-zika-virus-effective-childhood-cancer.html

  Furthermore, the mice did not develop any symptoms of Zika virus infection or any side effects. […] The researchers cautioned that the use of Zika virus as a cancer therapy will require extensive additional studies encompassing safety and efficacy. […] „With further validation, Zika virus could be an extremely effective bridge therapy for patients with high-risk neuroblastoma,” said Mazar. […] „Neuroblastoma is often a very challenging diagnosis, especially for the patients who are unlikely to respond well to chemotherapy,” said Matthew M. Davis, MD, MAPP, Executive Vice-President, Enterprise Physician-in-Chief and Chief Scientific Officer of Nemours.

• #77 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Overall, there have been multiple challenges associated with development of anti-Zika drugs as these drugs should be able to cross blood-brain barrier and placental barrier in pregnant people and should be safe for consumption during pregnancy. […] Moreover, any approved anti-Zika drug should be reasonably-priced as the majority of the ZIKV circulation occurs in tropical and sub-tropical countries with limited resources.

• #78 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Overall, there have been multiple challenges associated with development of anti-Zika drugs as these drugs should be able to cross blood-brain barrier and placental barrier in pregnant people and should be safe for consumption during pregnancy. […] Moreover, any approved anti-Zika drug should be reasonably-priced as the majority of the ZIKV circulation occurs in tropical and sub-tropical countries with limited resources.

• #79 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Overall, there have been multiple challenges associated with development of anti-Zika drugs as these drugs should be able to cross blood-brain barrier and placental barrier in pregnant people and should be safe for consumption during pregnancy. […] Moreover, any approved anti-Zika drug should be reasonably-priced as the majority of the ZIKV circulation occurs in tropical and sub-tropical countries with limited resources.

• #80 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  Overall, there have been multiple challenges associated with development of anti-Zika drugs as these drugs should be able to cross blood-brain barrier and placental barrier in pregnant people and should be safe for consumption during pregnancy. […] Moreover, any approved anti-Zika drug should be reasonably-priced as the majority of the ZIKV circulation occurs in tropical and sub-tropical countries with limited resources.

• #81

  https://link.springer.com/article/10.1007/s13311-017-0575-2

  Although antigenic variability between different strains, and even within the same strain, of ZIKV may pose as a drug design hurdle, some noteworthy inhibitors of viral attachment, entry, and fusion have surfaced. […] Antiviral activity against ZIKV was explored in vitro and in vivo for natural oxysterol, 25-hydroxycholesterol (25HC). […] Suramin is an FDA-approved antiparasitic with antiviral activity against flaviviruses. […] The NS2BNS3 protease is well conserved across the genus and no mutations have been acquired in the ZIKV protease sequence since 1967, making it a prime viral target. […] Several studies aimed at identifying inhibitors of the ZIKV protease have been initiated with moderate success. […] The potential for confounding effects introduced by the artificial linker has spurred the study of alternative constructs.

• #82 Zika Virus | Baltimore City Health Department

  https://health.baltimorecity.gov/zika-virus

  There is no anti-viral treatment and no vaccine to prevent from getting Zika at this time, though researchers are working hard to develop a vaccine against Zika. […] The Centers for Disease Control and Prevention is asking all pregnant women to consider postponing travel to areas with Zika transmission. If you must travel, talk to your doctor and strictly follow steps to prevent mosquito bites. Women trying to become pregnant should speak with their doctors before traveling. […] Without an existing cure or vaccine, prevention and preparedness are key to combating the spread of Zika.

• #83 I want to know about the Zika virus. Please guide.

  https://www.icliniq.com/qa/zika-virus/what-is-the-treatment-for-the-zika-virus

  To protect yourself from the Zika virus while traveling to India, particularly in places where it has been detected, use the same precautions as for dengue illness, but with some added considerations. Precautions for Zika virus include the following: Mosquito protection you can apply N, N-diethyl-meta-toluamide, picaridin, and lemon eucalyptus oil to exposed skin. Wear long-sleeved shirts, long pants, socks, and hats to protect your skin as much as possible. […] Additional steps for Zika are to use condoms or abstain from sex, as Zika can be transmitted sexually. Women who are pregnant or planning to become pregnant should avoid travel to areas with Zika outbreaks, as the virus can cause severe birth defects. […] Symptoms of Zika infection include fever, rash, joint pain, conjunctivitis, and other general symptoms like headache, muscle pain, and malaise. Potential risks include birth defects and neurological complications.

• #84 I want to know about the Zika virus. Please guide.

  https://www.icliniq.com/qa/zika-virus/what-is-the-treatment-for-the-zika-virus

  To protect yourself from the Zika virus while traveling to India, particularly in places where it has been detected, use the same precautions as for dengue illness, but with some added considerations. Precautions for Zika virus include the following: Mosquito protection you can apply N, N-diethyl-meta-toluamide, picaridin, and lemon eucalyptus oil to exposed skin. Wear long-sleeved shirts, long pants, socks, and hats to protect your skin as much as possible. […] Additional steps for Zika are to use condoms or abstain from sex, as Zika can be transmitted sexually. Women who are pregnant or planning to become pregnant should avoid travel to areas with Zika outbreaks, as the virus can cause severe birth defects. […] Symptoms of Zika infection include fever, rash, joint pain, conjunctivitis, and other general symptoms like headache, muscle pain, and malaise. Potential risks include birth defects and neurological complications.

• #85 Zika Virus Infection | Encephalitis International

  https://www.encephalitis.info/types-of-encephalitis/infectious-encephalitis/zika-virus-infection/

  There is currently no vaccine against ZIKV. Although several vaccine candidates have been studied, there is concern that immunization of individuals against ZIKV may exacerbate subsequent Dengue Virus (DENV) infection symptoms. In ZIKV endemic regions this question should be observed since there are multiple flaviviruses coexisting. Preventive measures include simple measures involving mosquito bite prevention (wearing trousers and long sleeves along with repellents use, bed nets).

• #86 I want to know about the Zika virus. Please guide.

  https://www.icliniq.com/qa/zika-virus/what-is-the-treatment-for-the-zika-virus

  To protect yourself from the Zika virus while traveling to India, particularly in places where it has been detected, use the same precautions as for dengue illness, but with some added considerations. Precautions for Zika virus include the following: Mosquito protection you can apply N, N-diethyl-meta-toluamide, picaridin, and lemon eucalyptus oil to exposed skin. Wear long-sleeved shirts, long pants, socks, and hats to protect your skin as much as possible. […] Additional steps for Zika are to use condoms or abstain from sex, as Zika can be transmitted sexually. Women who are pregnant or planning to become pregnant should avoid travel to areas with Zika outbreaks, as the virus can cause severe birth defects. […] Symptoms of Zika infection include fever, rash, joint pain, conjunctivitis, and other general symptoms like headache, muscle pain, and malaise. Potential risks include birth defects and neurological complications.

• #87 Zika Virus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430981/

  Currently, there is no treatment for Zika virus complicating pregnancy. Prevention is key. Pregnant women should avoid mosquito exposure, and avoid travel to known Zika virus areas, if possible. If unable to avoid exposure, testing, as described above, is recommended. If planning to become pregnant, the woman should avoid conception (abstinence or use of condoms) for at least 8 weeks after exposure or the start of symptoms. Men should avoid the risk of their partner conceiving (abstinence or use of condoms) for at least six months after exposure or initial symptoms. […] The Zika virus has recently emerged as a new mosquito-borne viral infection. While in most people the virus causes a harmless infection, there are many reports indicating that the virus can cause both neurological and eye problems. In addition, Pregnant women are at very high risk for delivering an infant with microcephaly. The virus is also known to be transmitted sexually. There is no cure for the Zika virus, and thus prevention is the key.

• #88 Zika Virus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430981/

  Currently, there is no treatment for Zika virus complicating pregnancy. Prevention is key. Pregnant women should avoid mosquito exposure, and avoid travel to known Zika virus areas, if possible. If unable to avoid exposure, testing, as described above, is recommended. If planning to become pregnant, the woman should avoid conception (abstinence or use of condoms) for at least 8 weeks after exposure or the start of symptoms. Men should avoid the risk of their partner conceiving (abstinence or use of condoms) for at least six months after exposure or initial symptoms. […] The Zika virus has recently emerged as a new mosquito-borne viral infection. While in most people the virus causes a harmless infection, there are many reports indicating that the virus can cause both neurological and eye problems. In addition, Pregnant women are at very high risk for delivering an infant with microcephaly. The virus is also known to be transmitted sexually. There is no cure for the Zika virus, and thus prevention is the key.

• #89 I want to know about the Zika virus. Please guide.

  https://www.icliniq.com/qa/zika-virus/what-is-the-treatment-for-the-zika-virus

  To protect yourself from the Zika virus while traveling to India, particularly in places where it has been detected, use the same precautions as for dengue illness, but with some added considerations. Precautions for Zika virus include the following: Mosquito protection you can apply N, N-diethyl-meta-toluamide, picaridin, and lemon eucalyptus oil to exposed skin. Wear long-sleeved shirts, long pants, socks, and hats to protect your skin as much as possible. […] Additional steps for Zika are to use condoms or abstain from sex, as Zika can be transmitted sexually. Women who are pregnant or planning to become pregnant should avoid travel to areas with Zika outbreaks, as the virus can cause severe birth defects. […] Symptoms of Zika infection include fever, rash, joint pain, conjunctivitis, and other general symptoms like headache, muscle pain, and malaise. Potential risks include birth defects and neurological complications.

• #90 Zika Virus | Baltimore City Health Department

  https://health.baltimorecity.gov/zika-virus

  There is no anti-viral treatment and no vaccine to prevent from getting Zika at this time, though researchers are working hard to develop a vaccine against Zika. […] The Centers for Disease Control and Prevention is asking all pregnant women to consider postponing travel to areas with Zika transmission. If you must travel, talk to your doctor and strictly follow steps to prevent mosquito bites. Women trying to become pregnant should speak with their doctors before traveling. […] Without an existing cure or vaccine, prevention and preparedness are key to combating the spread of Zika.

• #91 Treatment and Prevention of Zika Virus Disease | Zika Virus | CDC

  https://www.cdc.gov/zika/hcp/clinical-care/index.html

  There are no vaccines to prevent or medicines to treat Zika virus infection. […] There are no antiviral treatments available for Zika virus disease. Treatment is generally supportive and can include rest, fluids, and use of analgesics and antipyretics. […] Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided until dengue can be ruled out to reduce the risk of hemorrhage. […] Carefully monitor pregnant women with laboratory evidence of Zika virus infection. Closely manage these patients during pregnancy and carefully evaluate live-born infants for clinical features associated with intrauterine infection.

• #92 Zika Virus | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/z/zika-virus.html

  There is no medicine to cure the Zika virus. Treatment is aimed at easing symptoms. Rest and drinking plenty of fluids are helpful. Acetaminophen can help ease fever and pain. […] A pregnant person can pass the virus on to the unborn child, even without symptoms. The virus can cause a birth defect called microcephaly. […] There is no medicine to cure the Zika virus. Treatment is aimed at easing symptoms.

• #93 Zika Virus Treatment & Management: Approach Considerations, Medical Care, Complications

  https://emedicine.medscape.com/article/2500035-treatment

  There are no FDA-approved treatment options for Zika. Multiple antiviral drugs are under investigation for treatment of ZIKV infection. […] The anti-Zika drugs under investigation target various stages of viral life cycle with direct antiviral activity (nucleoside analogs, polymerase inhibitors, RNA-dependent RNA polymerase inhibitors such as sofosbuvir, galidesivir) or activity against host cell mechanisms (purine or pyrimidine synthesis inhibitors, entry inhibitors). […] Some of the anti-Zika drugs have shown promising efficacy in in-vivo and in-vitro studies. […] Few FDA-approved drugs for other non-Zika indications such as interferon (in-vitro antiviral activity), antimalarials like chloroquine and mefloquine (in-vitro anti-Zika activity and safe in all trimesters), anti-helminthics such as ivermectin (antiviral activity), and antibiotics like azithromycin (reduce infectivity) have potential anti-Zika activity but are still under investigation to establish efficacy and safety for use.

• #94 A Review of the Ongoing Research on Zika Virus Treatment

  https://www.mdpi.com/1999-4915/10/5/255

  In the search for effective antivirals, research centers have screened compounds which previously demonstrated to possess antiviral activity against other pathogens for their therapeutical potential against ZIKV infection. […] Some molecules, such as niclosamide, emricasan, ivermectin, MPA, and daptomycin, have shown to be effective on ZIKV infection in vitro by inhibiting viral entry into the cells and/or replication, or by decreasing cell death induced by infection. Natural compounds, synthetic compounds, and nucleoside analogs have been the subject of research in the search for new molecules that inhibit the infection caused by ZIKV, and some studies have demonstrated the therapeutic potential of these different approaches.

• #95 Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice – ecancer

  https://ecancer.org/en/news/24042-researchers-find-zika-virus-is-effective-when-used-to-treat-a-type-of-childhood-cancer-in-mice

  Researchers find Zika virus is effective when used to treat a type of childhood cancer in mice. […] Injecting neuroblastoma tumours with Zika virus shrank or eliminated those tumours in studies with mice, suggesting that the virus could someday serve as an effective cancer therapy. […] In recent years, researchers have discovered that Zika virus, which is carried by mosquitoes, can potentially be used to kill cancer cells. […] Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. […] The study showed that all mice injected with the Zika virus experienced a nearly total loss of tumour size. […] The highest dosage tested resulted in complete elimination of the tumour.

• #96 Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-024-04930-4

  Zika virus (ZIKV), a member of the flavivirus virus family, is one such virus candidate that is in the stage of early experimental development. […] ZIKV-LAV strains productively infected and lysed human GBM cells but not primary endothelia and terminally differentiated neurons. […] ZIKV-LAV infection in human GBM cells leads to both apoptotic and lytic cell death pathwaysparticularly pyroptosisduring late infection. […] ZIKV-LAV strains, particularly DN-1, exhibited potent oncolytic activity in human glioblastoma multiforme (GBM) cells without productively infecting non-cancer cells, such as terminally differentiated human neurons and primary endothelia. […] The reduced neurotropism also enhances cancer selectivity of ZIKV-LAV and, consequently, affords wider therapeutic window compared to wild-type ZIKV.

• #97 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  While no specific treatment exists, paracetamol (acetaminophen) and rest may help with the symptoms. […] Treatment of Zika includes getting plenty of rest, drinking a lot of fluids to stay hydrated, and over-the-counter medicines such as acetaminophen to relieve fever and pain. It is not recommended to take aspirin or other non-steroidal anti-inflammatory drugs until after dengue infection is ruled out. […] The World Health Organization has suggested that priority should be to develop inactivated vaccines and other nonlive vaccines, which are safe to use in pregnant women. […] As of March 2016, 18 companies and institutions were developing vaccines against Zika, but they state a vaccine is unlikely to be widely available for about 10 years. […] In June 2016, the FDA granted the first approval for a human clinical trial for a Zika vaccine.

• #98 Zika virus – Wikipedia

  https://en.wikipedia.org/wiki/Zika_virus

  In March 2017, a DNA vaccine was approved for phase-2 clinical trials. This vaccine consists of a small, circular piece of DNA, known as a plasmid, that expresses the genes for the Zika virus envelope proteins. As the vaccine does not contain the full sequence of the virus, it cannot cause infection. […] As of April 2017, both subunit and inactivated vaccines have entered clinical trials. However, like vaccines for other arboviruses, it is difficult to counteract an epidemic of this virus due to how it can appear sporadically and unpredictably.

• #99 Zika Virus | Baltimore City Health Department

  https://health.baltimorecity.gov/zika-virus

  There is no anti-viral treatment and no vaccine to prevent from getting Zika at this time, though researchers are working hard to develop a vaccine against Zika. […] The Centers for Disease Control and Prevention is asking all pregnant women to consider postponing travel to areas with Zika transmission. If you must travel, talk to your doctor and strictly follow steps to prevent mosquito bites. Women trying to become pregnant should speak with their doctors before traveling. […] Without an existing cure or vaccine, prevention and preparedness are key to combating the spread of Zika.

• #100 I want to know about the Zika virus. Please guide.

  https://www.icliniq.com/qa/zika-virus/what-is-the-treatment-for-the-zika-virus

  To protect yourself from the Zika virus while traveling to India, particularly in places where it has been detected, use the same precautions as for dengue illness, but with some added considerations. Precautions for Zika virus include the following: Mosquito protection you can apply N, N-diethyl-meta-toluamide, picaridin, and lemon eucalyptus oil to exposed skin. Wear long-sleeved shirts, long pants, socks, and hats to protect your skin as much as possible. […] Additional steps for Zika are to use condoms or abstain from sex, as Zika can be transmitted sexually. Women who are pregnant or planning to become pregnant should avoid travel to areas with Zika outbreaks, as the virus can cause severe birth defects. […] Symptoms of Zika infection include fever, rash, joint pain, conjunctivitis, and other general symptoms like headache, muscle pain, and malaise. Potential risks include birth defects and neurological complications.

Zobacz więcej