Materiały źródłowe

• #1 Vitamin C deficiency – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/632

  Vitamin C deficiency can lead to scurvy, a potentially life-threatening condition. […] If not treated promptly, scurvy can be fatal. […] Complete recovery is anticipated in most patients. […] Rapid resolution occurs after vitamin C treatment.

• #2 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Scurvy is a rare and reversible condition that requires early diagnosis and treatment. […] This activity reviews the historical background, clinical manifestations, diagnosis, treatment, and preventive measures concerning vitamin C deficiency. […] The appropriate dosage of vitamin C for scurvy treatment varies based on the severity of the condition and the individual’s particular requirements. Prompt vitamin C supplementation can quickly and efficiently replenish depleted vitamin levels in patients, with dosages up to 300 mg/d for children and 500 to 1000 mg/d for adults. […] Treating scurvy involves consuming sufficient fruits and vegetables to prevent recurrences and addressing the underlying causes of malnutrition that lead to vitamin C deficiency. […] Supplements are readily available for individuals unwilling or unable to obtain adequate vitamin C solely from their diet, including standard over-the-counter multivitamin preparations.

• #3 Scurvy: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24318-scurvy

  Scurvy treatment is essential to avoid further complications. The condition is easily treatable by consuming more vitamin C. You should try to maintain a nutritious diet that includes one to two times your daily recommended amount of vitamin C. You can do so by adding fresh fruits and vegetables to every meal. […] Your healthcare provider may also recommend taking a vitamin C supplement until you feel better. Children with scurvy can take a supplement of up to 300 milligrams (mg) daily. Adults can take between 500 mg and 1000 mg. […] Most people feel better within 48 hours of treatment. You should be able to make a full recovery within two weeks. Some symptoms may take longer to fully clear up. Depending on the cause of your condition, your provider may refer you to a specialist for further treatment.

• #4 Scurvy: Symptoms, causes, treatment, and prevention

  https://www.medicalnewstoday.com/articles/155758

  Scurvy is treatable with oral or intravenous vitamin C supplements. […] Treatment involves administering vitamin C supplements by mouth or by injection. […] The recommended dosage for adults is: 1,000 milligrams (mg) per day for at least 1 week; 300-500 mg for 1 week. […] Within 24-72 hours, people can expect to see an improvement in fatigue, lethargy, pain, anorexia, and confusion. […] After 3 months, a complete recovery is possible. Long-term effects are unlikely, except in the case of severe dental damage. […] The treatment is to consume vitamin C through either diet or supplements.

• #5 Scurvy? Symptoms, Causes and Treatments

  https://www.webmd.com/skin-problems-and-treatments/what-to-know-scurvy

  Scurvy Treatment […] Modern treatment of scurvy is quite simple. You’ll want to talk to your doctor, but they’ll likely suggest adding more fresh fruits and vegetables to your diet, as well as a vitamin C supplement. Most people feel better within 48 hours and are completely cured within two weeks. […] Your doctor may also suggest that you see a specialist for treatment, support, or advice, depending on the reason why you developed scurvy in the first place. They may also test for other vitamin deficiencies. […] You’ll want to make sure to address the underlying cause of scurvy, so you don’t have a relapse. […] Treatment for scurvy involves boosting vitamin C through supplements or foods.

• #6 Scurvy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2567249/

  The treatment for scurvy is vitamin C supplementation. Recommendations are that 1 to 2 grams of vitamin C be administered daily for the first 2 to 3 days followed by 500 mg per day for the next week. Afterward, a daily intake of 100 mg of vitamin C should be given for 1 to 3 months. Symptoms of fatigue, lethargy, pain, anorexia, and confusion improve within 24 hours of supplementation. Bruising, perifollicular hemorrhages, gingival bleeding, and weakness usually improve within 1 to 2 weeks. Corkscrew hairs regain normal appearance by 4 weeks. Complete recovery should be anticipated after approximately 3 months of regular vitamin C supplementation. […] Treatment consists of a regimen of vitamin C supplementation. Complete recovery usually occurs after 3 months of regular supplementation.

• #7 Scurvy (Vitamin C Deficiency) Treatment & Management: Approach Considerations, Ascorbic Acid, Diet

  https://emedicine.medscape.com/article/125350-treatment

  Because sudden death may occur in patients with scurvy, ensuring adequate vitamin C replenishment in patients with vitamin C deficiency is the hallmark of therapy. Restoration of body stores of vitamin C is essential to achieve complete resolution of symptoms. In most adult patients, provision of 250 mg of vitamin C four times a day for 1 week aids in achieving this goal. […] Identifying and treating comorbid nutritional deficiencies (eg, iron deficiency anemia, folate deficiency, other vitamin deficiencies) are integral parts of management. Provision of a balanced and liberal diet to meet the nutritional needs of the patient aids in recovery. […] Patients should take oral ascorbic acid at 100 mg 3-5 times a day until a total of 4 g is reached, and then they should decrease intake to 100 mg daily. Alternatively, ascorbic acid may be taken at 1 g/day for the first 3-5 days, followed by 300-500 mg/day for 1 week. Then, the recommended daily allowance is resumed.

• #8 Scurvy: Rediscovering a Forgotten Disease

  https://www.mdpi.com/2079-9721/11/2/78

  Scurvy has been an unusual cause of gastrointestinal (GI) bleeding among other GI manifestations. It can be adequately treated and prevented via vitamin C supplementation. […] The treatment for scurvy is vitamin C supplementation and the reversal of the conditions that led to the deficiency. A wide range of replacement doses have been used successfully. For children, recommended doses are 100 mg of ascorbic acid given three times daily (orally, intramuscularly, or intravenously) for one week, then once daily for several weeks until the patient is fully recovered. Adults are usually treated with 300 to 1000 mg/day for one month. […] If scurvy is suspected, it can be effectively treated with high doses of Vitamin C. It has been reported that after just one replacement dose, gastrointestinal bleeding related to vitamin C deficiency will stop, and capillary stability will be established within 24 h. However, it can take up to 2–3 weeks for other symptoms of scurvy, such as skin lesions, to heal. The treatment of scurvy begins with high doses of Vitamin C: replacement is needed to replace the deficit in body stores. A recommended treatment course is an initial dosing of 1000 mg of intravenous ascorbic acid daily for 3 days, followed by further supplementation as needed with a dose of 250 to 500 mg twice daily for 1 month after discharge or longer if vitamin C cannot be obtained via diet.

• #9 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  The recommended daily intake of Vitamin C in Australia and New Zealand is 45 mg/d. Pregnant and lactating women need 55-85 mg/d. Smokers also require a higher Vitamin C intake due to increased metabolic turnover. A well-balanced diet including fresh fruit and vegetables provides sufficient Vitamin C for most people. […] Adults: Oral Vitamin C 1000 mg/d in divided doses for at least one week, then 300-500 mg/d for a further week, followed by the recommended daily allowance. […] Children: The American Academy of Paediatrics recommends children receive 100 mg 3 times daily for at least 1 week, followed by 100 mg daily until symptoms have resolved. […] Vitamin C can also be given intravenously, intramuscularly, or per rectum. […] Transfusion is sometimes required for severe anaemia, especially if acute related to haemorrhage.

• #10 Food Fighting and Curing Disease Series: Scurvy —

  https://foodmedcenter.org/food-fighting-and-curing-disease-series-scurvy/

  Scurvy is a disease that results from a vitamin C deficiency. It can lead to anemia, exhaustion, spontaneous bleeding, limb pain, swelling, and sometimes ulceration of the gums and loss of teeth. […] Treatment involves administering vitamin C supplements. […] The recommended dosages are: Adults: 1 to 2 grams of vitamin C be administered daily for the first 2 to 3 days, followed by 500 mg per day for the next week. Afterward, a daily intake of 100 mg of vitamin C should be given for 1 to 3 months. […] Within 24-72 hours, people can expect to see an improvement in fatigue, lethargy, pain, anorexia, and confusion. Meanwhile, full recovery can be expected in 1-3 months.

• #11

  https://www.orthobullets.com/basic-science/9034/scurvy

  Scurvy is disease caused by severe Vitamin C deficiency which presents with joint effusions, swelling over long bones, bleeding gums, loosening of teeth, hematuria, and susceptibility to hemorrhage. […] Diagnosis is made based on history, clinical and radiological picture, and resolution of symptoms following vitamin C administration. Lab tests are usually not helpful. […] Treatment is prompt administration of Vitamin C. […] Nonoperative vitamin C replacement is indicated for signs and symptoms of scurvy and chronic malnutrition. […] Oral vitamin C at 250mg qid x 1 week in adults is a recommended technique. […] Excellent prognosis if treated early.

• #12 Vitamin C Deficiency – Nutritional Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-c-deficiency

  Treatment of vitamin C deficiency consists of oral vitamin C. […] For scurvy in adults, ascorbic acid is given. One reasonable regimen is 500 to 1000 mg orally once a day for 1 to 2 weeks, until signs disappear, followed by a nutritious diet supplying 1 to 2 times the daily recommended intake. […] In scurvy, therapeutic doses of ascorbic acid restore the functions of vitamin C in a few days. The symptoms and signs usually disappear over 1 to 2 weeks. Chronic gingivitis with extensive subcutaneous hemorrhage persists longer. […] Treat with supplemental ascorbic acid and a nutritious diet.

• #13 Effective Scurvy Treatments: Vitamin C Dosage& Recovery Insights

  https://www.medicoverhospitals.in/articles/scurvy-treatment

  The dosage of vitamin C for treating scurvy depends on the severity of the deficiency and the patient’s age. For adults, the typical dosage for treating scurvy ranges from 100 to 300 milligrams of vitamin C daily. In severe cases, higher doses may be necessary under medical supervision. It’s essential to continue the treatment until symptoms resolve and vitamin C levels normalize. […] Children with scurvy require lower doses of vitamin C. The recommended dosage is typically around 50 to 100 milligrams daily, adjusted based on the child’s age and severity of the deficiency. As with adults, treatment should continue until symptoms improve and vitamin C levels are restored. […] The recovery process from scurvy is gradual and can vary depending on the severity of the condition and the individual’s overall health. Within a few days of starting vitamin C therapy, patients often experience an improvement in symptoms such as fatigue and gum bleeding. This initial phase is crucial for confirming the diagnosis and ensuring the treatment is effective.

• #14 Scurvy (Vitamin C Deficiency) Treatment & Management: Approach Considerations, Ascorbic Acid, Diet

  https://emedicine.medscape.com/article/125350-treatment

  In October 2017, the Food and Drug Administration (FDA) approved Ascor (ascorbic acid) for the short-term (1 wk) treatment of scurvy in adults and children aged 5 months or older for whom oral administration is not possible, is insufficient, or is contraindicated. The exact mechanism of action of ascorbic acid for the treatment of scurvy is unknown. It is believed that the administration restores the body pool of ascorbic acid. […] The recommended adult dose is 200 mg IV daily, and treatment should not exceed 7 days. If there is no improvement in scorbutic symptoms, re-treat until resolution of scorbutic symptoms is observed.

• #15 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

• #16 Scurvy | nidirect

  https://www.nidirect.gov.uk/conditions/scurvy

  Scurvy is easily treated by adding some vitamin C to your diet, such as fresh fruit and vegetables. […] Your GP may also recommend taking vitamin C supplements until you feel better. […] Most people treated for scurvy feel better within 48 hours and make a full recovery within two weeks. […] Your GP may refer you to a specialist for treatment, support or advice. This depends on what’s causing your scurvy.

• #17 What Is Scurvy? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/scurvy/

  All management of severe vitamin C deficiency should be under the direction of your healthcare team. […] The only medication to treat scurvy is vitamin Crich foods and vitamin C supplementation (pill form, intravenous, or injected). […] To prevent scurvy, make sure youre getting enough vitamin C. […] Springer suggests shooting for five servings of a variety of fruits and vegetables each day. Thatll put you at around 200 mg of vitamin C, she says, which gives you a little more than the recommended daily intake, to make sure youre covered.

• #18 Vitamin C Deficiency: Symptoms and Treatment

  https://patient.info/healthy-living/vitamin-c-deficiency-leaflet

  Persistent lack of dietary vitamin C in can lead to a condition called scurvy. […] Vitamin C deficiency can be treated with supplements of vitamin C and a diet rich in vitamin C. […] The treatment for vitamin C deficiency is to replace the vitamin C that is lacking in the diet. This can be achieved by taking vitamin C supplements and by eating a diet rich in vitamin C. […] After a period of time, vitamin C supplements can usually be stopped. However, it is important to continue to eat a diet rich in vitamin C after the supplements are stopped. This will help to avoid becoming deficient in vitamin C again. […] People with vitamin C deficiency usually make a full recovery. Once treatment to replace vitamin C is started, symptoms usually quickly improve within days or weeks.

• #19 Scurvy: Symptoms, Causes and Treatment | U.S. NewsCalifornia Consumer Privacy Act (CCPA) Opt-Out Icon

  https://health.usnews.com/wellness/articles/scurvy-symptoms-and-causes

  Scurvy Treatments […] The good news is treating scurvy early is exceedingly easy and inexpensive with vitamin C supplements. Pediatric patients are often treated with 100 to 300 milligrams daily and adults with 500 to 1,000 milligrams daily for one month or until symptoms resolve. […] Pediatric patients can experience relief from scurvy very quickly once treated. Most patients show improvement within 48 hours, according to Gilley. […] Once scurvy has resolved, it’s important to maintain a healthy, vitamin C-rich diet to prevent it from returning.

• #20 Scurvy (Vitamin C Deficiency) Medication: Vitamins

  https://emedicine.medscape.com/article/125350-medication

  The only effective therapy for scurvy is vitamin C replacement. Thus, the goal of treatment is to saturate the body rapidly with ascorbic acid; at maximum doses, body stores become saturated in a few days. With proper treatment, bleeding stops within 24 hours, and perifollicular petechiae resolve in 2 weeks. […] Ascorbic acid (vitamin C) administered orally or parenterally effectively cures infantile and adult scurvy. This vitamin is used by the body for collagen synthesis and tissue repair.

• #21 Scurvy | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/scurvy/

  Scurvy can simply be treated by consumption of vitamin C supplements, which can help patients recover from its symptoms in a couple of days. […] Once this condition improves, consumption of fresh vegetables and fruits is recommended to maintain the level of vitamin C. […] Generally it takes two weeks to fully recover from the disease.

• #22 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Children with bone disease may require surgery if symptoms do not resolve with supplements. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities.

• #23 Scurvy: A Comprehensive Guide to Vitamin C Deficiency

  https://www.amritahospitals.org/kochi/blog/scurvy-what-you-need-to-know-to-identify-and-prevent-the-vitamin-c-deficiency

  Scurvy can lead to various complications, which require additional medical attention: Treatment for swollen and bleeding gums may involve professional dental cleaning and mouth rinses. […] Special wound care is needed for ulcers or slow-healing injuries. […] Nonsteroidal anti-inflammatory drugs (NSAIDs) or other pain management strategies may be employed for joint and muscle pain. […] In cases where anaemia develops, iron supplementation or transfusions may be necessary. […] Early diagnosis and treatment are crucial to prevent complications and promote a full recovery.

• #24 Vitamin C deficiency (Scurvy) – Cancer Therapy Advisor

  https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/pediatrics/vitamin-c-deficiency-scurvy/

  Treatment of scurvy is simple, with vitamin C supplementation generally in the range of 100-300 mg per day. Treatment is well tolerated, with diarrhea being the most commonly reported side effect if excessive vitamin C is taken, but this is unusual. […] Other micronutrients (i.e., iron and vitamin D) may also be necessary. […] Recovery is usually prompt with constitutional symptoms, with bleeding and gum disease improving within days. Depending on the duration of symptoms prior to treatment and whether muscle atrophy is present, bone disease and musculoskeletal function may take weeks for recovery.

• #25 Scurvy: Symptoms, Causes, Vitamin C Intake, and Treatment

  https://resources.healthgrades.com/right-care/food-nutrition-and-diet/scurvy

  In some cases, medical professionals may prescribe very high doses of vitamin C to help resolve scurvy in a few days. […] Your medical team may also recommend treatments to help soothe any scurvy symptoms or complications. For instance, they may refer you to a periodontist to address gum and tooth damage. […] The main treatment for scurvy is increasing your dietary intake of vitamin C or trying supplements.

• #26 Effective Scurvy Treatments: Vitamin C Dosage& Recovery Insights

  https://www.medicoverhospitals.in/articles/scurvy-treatment

  Adults, particularly those with restrictive diets or limited access to fresh produce, are at risk of developing scurvy. Treatment involves dietary changes and supplements to restore vitamin C levels. Regular medical check-ups can monitor progress and ensure ongoing health. […] Children are particularly vulnerable to scurvy if their diets lack sufficient fruits and vegetables. Parents and caregivers should ensure that children receive a balanced diet with adequate vitamin C. Pediatricians can guide appropriate dosages for supplements if needed. […] Scurvy treatment in children often involves higher doses of vitamin C relative to body weight and more frequent monitoring, while adults generally receive standard doses and dietary adjustments. Both groups benefit from a vitamin C-rich diet and supplements if necessary.

• #27 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal

  https://amj.amegroups.org/article/view/9986/html

  Scurvy is a multi-organ syndrome caused by a deficiency of vitamin C. […] This report aims to highlight the diversity of risk factors for vitamin C deficiency and the challenges of treating patients facing barriers to adequate nutrition and healthcare access. […] A diagnosis of scurvy was confirmed with undetectable serum vitamin C (0.1 mg/dL; reference range, 0.42.0 mg/dL), and a subsequent dietary history revealed recent food insecurity. Vitamin C 500 mg was supplemented twice daily for 14 days. […] Treatment includes high-dose vitamin C supplementation, but careful patient education and interdisciplinary support may be necessary to prevent recurrence in high-risk populations. […] Despite its perception as a historical disease, scurvy occurs in the modern era. […] Adequate supplementation and dietary education are essential to prevent recurrence, and interdisciplinary support is necessary to improve nutrition access to patients experiencing barriers to care.

• #28 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal

  https://amj.amegroups.org/article/view/9986/html

  The treatment of scurvy involves prompt vitamin C supplementation, and the appropriate dosing varies based on the severity of the condition and the individuals requirements. […] Although our patient received 14 days of appropriate high-dose supplementation, he subsequently underwent a self-directed discharge and continued dialysis without regular access to nutrition which may explain his improved but persistently low serum vitamin C level at follow-up. […] Healthcare providers should maintain a high index of suspicion for nutrient deficiencies and consider a detailed dietary history, clinical nutritionist engagement, and selective laboratory testing when treating high-risk populations presenting with unexplained bleeding, new neuropsychiatric symptoms, or skin and body hair changes. Adequate supplementation with vitamin C should be initiated promptly in suspected cases of scurvy, and nutrition education should be provided to prevent recurrence.

• #29 Scurvy: A Comprehensive Guide to Vitamin C Deficiency

  https://www.amritahospitals.org/kochi/blog/scurvy-what-you-need-to-know-to-identify-and-prevent-the-vitamin-c-deficiency

  Scurvy is a completely treatable condition when diagnosed early and managed appropriately. The focus of the treatment is replenishing the body’s vitamin C levels and addressing any complications caused by the deficiency. […] The primary treatment for scurvy is vitamin C replacement therapy. […] Oral Supplements: Adults typically require 300-1000 mg of vitamin C per day for 1-2 weeks until symptoms improve. […] Maintenance doses of 75-90 mg daily will help prevent recurrence. […] Intravenous Vitamin C is administered in severe cases where oral supplementation is not possible due to malabsorption or gastrointestinal issues. […] Improving the diet to include vitamin C-rich foods is essential for long-term recovery and prevention. […] An expert dietician can help develop a balanced meal plan tailored to the patient’s needs and preferences.

• #30 Scurvy: Symptoms and Treatment – Terapia Online Presencial Madrid | Mentes Abiertas

  https://mentesabiertaspsicologia.com/blog-psicologia/scurvy-symptoms-and-treatment

  The treatment of scurvy is based on supplementation with vitamin C and in improving the intake of foods rich in this vitamin. In severe cases, intravenous administration of vitamin C may be necessary to restore adequate levels in the body. […] Vitamin C supplements are available in the form of tablets, capsules, or liquid solutions. These help restore optimal levels of vitamin C in the body and reverse the symptoms of scurvy. […] It is essential to include foods rich in vitamin C in the daily diet to prevent and treat scurvy. Eating fruits such as oranges, lemons, strawberries and kiwis, as well as vegetables such as peppers, broccoli and spinach, is essential to maintain adequate levels of this vitamin. […] It is important to carry out adequate medical follow-up to monitor the evolution of scurvy and ensure that the treatment is being effective. In severe cases, supervision by a specialized medical team may be required.

• #31 Case Report: Scurvy in an Incarcerated Man – Clinical Advisor

  https://www.clinicaladvisor.com/features/case-report-scurvy-incarcerated-man/2/

  Upon return to the correctional facility, a follow-up history and physical examination are performed by the patients primary care provider and include discussion of why the patient is on a restrictive diet. He explains that his goal is to stay attractive. He is counseled on proper diet and nutrition and treated with 500-mg vitamin C twice a day. […] The treatment of scurvy is vitamin C supplementation. Mild cases of scurvy may be optimally treated with oral vitamin C. Dosage for adults is between 500 to 1000 mg per day for 1 month. For children, dosage begins at 100 mg 3 times per day for 1 week, followed by 100 mg per day until symptoms resolve. Patient education on a healthy diet is important, especially in patients with special needs. More extreme cases may require intravenous treatment, hospitalization, treatment of underlying conditions, and supportive care.

• #32 Scurvy – Don’t Forget the Bubbles

  https://dontforgetthebubbles.com/scurvy/

  Scurvy is rare in higher income countries and therefore often forgotten as a potential differential diagnosis. […] The diagnosis is, in the main, a clinical one. When signs and symptoms respond to dietary changes or supplementation with Vitamin C, you know you are on the right track. […] Vitamin C supplementation orally for children with 100-300mg for one month or until full recovery. […] Referral to a dietician for dietary education is imperative. […] Resolution of symptoms can start within 24 hours but may require a few weeks of treatment to fully resolve. […] Scurvy is a preventable, easily treatable disease that, due to its non-specific symptoms, is often misdiagnosed or carries a delay in diagnosis, with patients presenting to healthcare professionals on multiple occasions. An excellent nutritional history is critical to diagnosis.

• #33 shropshireguineapiggery – Scurvy & Vit C

  https://www.shropshireguineapiggery.co.uk/caring-for-your-guinea-pig/scurvy-vit-c/

  Seriously consider whether additional supplementation is necessary. Adequate Vitamin C should be achieved easily through a varied diet and they should not need any extra added to water etc. We do not give Vitamin drops in water bottles. They don’t need it as too much Vit C can also be harmful. […] If your guinea pig is poorly or has a condition where additional supplementation is required, this should always be under the advice of a good exotic vet. […] Did you know? […] Young Guinea pigs under 6 months are at greater risk because of rapidly developing bone and increased use of vitamin C. […] Although guinea pig pelleted diets are fortified with vitamin C, the content is reduced by storage, light, heat, and moisture. As much as 50% of vitamin C activity can be lost within 6 weeks of storage; therefore, it is recommended to feed product within 90 days of production. […] Vitamin C activity is diminished by water, so supplementation of drinking water may be ineffective anyway by as much as 50% of activity is lost within 24 hours.

• #34 Intravenous High-Dose Vitamin C in Cancer Therapy – NCI

  https://www.cancer.gov/research/key-initiatives/ras/news-events/dialogue-blog/2020/yun-cantley-vitamin-c

  However, it is worth noting that a significant number of people even in developed countries are still vitamin C deficient. […] For example, approximately 7% of the US population has a plasma vitamin C concentration of less than 11 M, that is considered scurvy. […] Vitamin C has many essential functions in our body in addition to its well-known role as an antioxidant. […] Thus, prolonged periods of sub-optimal vitamin C exposure could have adverse health effects, including an increased susceptibility to a plethora of diseases. […] Vitamin C cancer therapy has a long history of controversy. […] Although many preclinical studies showed high dose vitamin C could kill cancer cells or retard tumor growth in vivo, vitamin Cs mechanisms of action have not been clear, making it hard to predict the pharmacodynamics, the rational design of combinational therapy, and biomarkers for patient stratification.

• #35

  https://journals.lww.com/onlinejets/fulltext/2024/17020/scurvy__a_rare_disease_or_a_rare_diagnosis_.2.aspx

  Scurvy is a disease state caused by a deficiency of Vitamin C, or ascorbic acid. The therapy is simple: Ascorbic acid, 100 mg, by oral or intravenous routes, several times a day. Signs and symptoms usually resolve rapidly with ascorbic acid administration. […] Each patient had a known risk factor for inadequate Vitamin C intake. All had clinical findings suggestive of scurvy and all but one had a subnormal serum Vitamin C level detected on serum samples sent from the ED. […] All patients, except one who left against medical advice (AMA), were admitted to the hospital and responded to the repletion of Vitamin C with resolution of the clinical symptoms of scurvy. […] We recommend obtaining Vitamin C levels in patients at risk for scurvy who present with equivocal symptoms including severe fatigue, nonspecific rashes, and joint pain.

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