Materiały źródłowe

• #1 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Vitamin C deficiency, commonly called scurvy, is a well-documented nutritional disorder with historical significance that continues to impact global health today. Classic signs of vitamin C deficiency include corkscrew hairs, perifollicular hemorrhages, and gingival bleeding. Scurvy is a clinical syndrome resulting from vitamin C deficiency. Symptoms of scurvy appear within 4 to 12 weeks of insufficient vitamin C intake. Initially, nonspecific symptoms of scurvy emerge after 4 to 12 weeks of insufficient intake of vitamin C. Patients might present with fatigue, malaise, lethargy, and anorexia. Subsequently, patients with scurvy experience oral and skin symptoms such as bleeding gums, easy bruising, skin rashes, fragility, delayed wound healing, and bone and joint aches. Corkscrew strands, characterized by twisted or coiled hair shafts, result from impaired collagen synthesis and are considered pathognomonic for scurvy. As scurvy progresses, its symptoms become increasingly severe and life-threatening. If left untreated, severe scurvy can induce profound weakness, dyspnea, anasarca, hemolysis, jaundice, seizures, organ failure, and ultimately, death. Typically, symptoms of fatigue, body aches, and anorexia improve within 24 hours of treatment. Additional symptoms such as bruising, gingival bleeding, perifollicular hemorrhage, and weakness tend to respond within 1 to 2 weeks following treatment initiation. Corkscrew hairs usually return to their normal appearance within 1 month, and most symptoms tend to resolve completely within 3 months.

• #1 Scurvy: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24318-scurvy

  The first symptoms of scurvy may develop after a few months of vitamin C deficiency. Symptoms of scurvy range from fatigue to bleeding gums. […] Scurvy symptoms may start to develop after a few months of not getting enough vitamin C in your diet. The first symptoms may include general weakness, fatigue, irritability and joint pain. […] If left untreated, more severe symptoms may start to develop. These may include: Anemia. Swollen, bleeding gums that may become purple and spongy. Loosened teeth that may fall out. Bleeding under your skin (skin hemorrhages). You may develop a scurvy rash that shows up as red or blue spots on your skin. Easily bruised skin. Rough, scaly skin. Swollen legs. Opening of previously healed wounds and new wounds that dont heal. Dry, brittle hair that coils like a corkscrew.

• #1 Scurvy – Wikipedia

  https://en.wikipedia.org/wiki/Scurvy

  Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. […] Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding from the skin may occur. […] As scurvy worsens, there can be poor wound healing, personality changes, and finally death from infection or bleeding. […] Early symptoms are malaise and lethargy. After one to three months, patients develop shortness of breath and bone pain. […] Other symptoms include skin changes with roughness, easy bruising, and petechiae, gum disease, loosening of teeth, poor wound healing, and emotional changes (which may appear before any physical changes). […] In the late stages, jaundice, generalised edema, oliguria, neuropathy, fever, convulsions, and eventual death are frequently seen.

• #1 Scurvy (Vitamin C Deficiency) Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/125350-clinical

  Symptoms and signs of scurvy may be remembered by the 4 Hs: hemorrhage, hyperkeratosis, hypochondriasis, and hematologic abnormalities. […] The initial symptoms of scurvy are nonspecific and include the following: malaise, lethargy, loss of appetite, peevishness (ill-tempered), poor weight gain, diarrhea, tachypnea, and fever. […] After 1-3 months of severe or total vitamin C deficiency, patients develop shortness of breath and bone pain. Myalgias may occur because of reduced carnitine production. Skin changes with roughness, easy bruising and petechiae, gum disease, loosening of teeth, poor wound healing, and emotional changes occur. […] In the late stages, jaundice, generalized edema, oliguria, neuropathy, fever, and convulsions can be seen. Left untreated, scurvy progresses, with potentially fatal complications, including cerebral hemorrhage or hemopericardium.

• #1 Scurvy: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24318-scurvy

  In babies and children, symptoms of scurvy may include: Irritability. Pain when they move. No appetite. Failure to gain weight. Anemia. […] A severe lack of vitamin C in your diet for at least three months can cause scurvy. […] With immediate treatment, the symptoms of scurvy should start to pass within 24 to 48 hours. Some symptoms may take longer to go away. Dental and gum issues as well as corkscrew hairs may take weeks to months to disappear. Severe gum disease may cause permanent damage.

• #1 Scurvy? Symptoms, Causes and Treatments

  https://www.webmd.com/skin-problems-and-treatments/what-to-know-scurvy

  Scurvy is a progressive disease; the longer it’s left untreated, the more symptoms you’ll have. Some of the most common symptoms include: […] Lethargy, along with body weakness, can be so intense that you’re unable to get out of bed. It’s usually the first symptom to appear. This led to the common belief that scurvy was actually caused by laziness. […] Aches are felt primarily in the joints, but they aren’t limited there. It may feel similar to body aches from the flu. […] Noticeable swelling happens mostly in your arms and legs. […] The slightest touch will cause bruising. Internal bleeding will cause your skin to look splotchy. […] Your gums turn spongy and porous. Your breath will smell rotten, and your teeth may start to loosen in their sockets. […] There isn’t enough collagen left in your body to continue creating scar tissue, so old wounds may start opening. Mucous membranes (which include your lips, mouth, nasal passages, and middle ear) may also bleed.

• #1 Scurvy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2567249/

  A 47-year-old male presented to the emergency department with a progressive onset of confusion, lethargy, anorexia, fatigue, weakness, and a diffuse nonpruritic perifollicular rash. […] Clinical manifestations of scurvy can be seen within 8 to 12 weeks of irregular or inadequate intake. Presentation can vary by individual. Early stages are often characterized by malaise, fatigue, and lethargy. One to 3 months of inadequate intake can lead to anemia, myalgia, bone pain, easy bruising, swelling, petechiae, perifollicular hemorrhages, corkscrew hairs, gum disease, poor wound healing, mood changes, and depression. […] Late stages of scurvy are more severe and life threatening; common manifestations include generalized edema, severe jaundice, hemolysis, acute spontaneous bleeding, neuropathy, fever, convulsions, and death.

• #1 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  My patient came to me in agony. His hands and feet hurt, and had for many years, and his gums were swollen. […] I thought about his other symptomsfrequent bruising, severe dental disease, and poor wound healing. This was a textbook presentation of vitamin C deficiency. My patient had one of the oldest recorded ailments in human history: scurvy. […] Scurvy is a disease resulting from inadequate vitamin C intake for at least three months. While vitamin C deficiency can cause mild symptoms like fatigue, weakness, or irritability, scurvy occurs when a person does not consume adequate amounts of vitamin C necessary for metabolic function. Vitamin C, or ascorbic acid, is also essential for producing collagen, a protein crucial for repairing and maintaining skin, blood vessels, bones, and connective tissues. Without sufficient collagen, individuals with scurvy may experience symptoms such as loose teeth, joint pain, bruising, anemia, and slow wound-healing.

• #1 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

  If left untreated, scurvy can cause life threatening conditions. […] Untreated scurvy can be a life threatening condition and cause death. […] Most people begin to recover from scurvy fairly quickly after starting treatment. You should see an improvement in some symptoms within 1 to 2 days of treatment, including: pain, exhaustion, confusion, headache, mood swings. […] Other symptoms may take a few weeks to improve following treatment, including: weakness, bleeding, bruising, jaundice. […] If left untreated, chronic scurvy can cause serious health complications.

• #1 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/125350-overview

  Scurvy is a state of dietary deficiency of vitamin C (ascorbic acid). The body’s pool of vitamin C can be depleted in 1-3 months. Signs and symptoms include fatigue, malaise, anemia, myalgia, bone pain, easy bruising, swelling, petechiae, gingivitis, perifollicular hemorrhages, corkscrew hairs, and poor wound healing. If left untreated, the disease can progress to jaundice, neuropathy, hemolysis, seizures, and death. […] The only effective therapy for scurvy is vitamin C replacement. Thus, the goal of treatment is to saturate the body rapidly with ascorbic acid; at maximum doses, body stores become saturated in a few days. With proper treatment, bleeding stops within 24 hours, and perifollicular petechiae resolve in 2 weeks. […] In advanced scurvy, serum bilirubin normalizes in less than 1 week, and anemia is corrected in less than a month.

• #1 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Splinter haemorrhages in the nails. […] Red, swollen gums in patients with teeth (particularly around the upper incisors) which may later become purple or black. […] Bleeding from the gums. […] Loosening and loss of teeth. […] Painful haemarthosis. […] Subperiosteal haemorrhage, particularly femur and proximal tibia. […] Costochondral junction beading scorbutic rosary. […] Intramuscular bleeding leading to woody oedema. […] Severe pain of arms and legs (the major feature of scurvy in infants) and reluctance to walk. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #1 How Would You Know If a Person Has Scurvy?

  https://www.medicinenet.com/how_would_you_know_if_a_person_has_scurvy/article.htm

  All of these symptoms are byproducts of the lack of vitamin C, which reduces the amount of collagen in your connective tissues. Collagen is a protein that the body uses to repair and strengthen connective tissues. […] Without vitamin C to produce collagen, your connective tissues break down in your skin, bones, blood vessels, tendons, and muscles. This leads to the pain and weakness associated with the disease.

• #1 15 Signs and Symptoms of Vitamin C Deficiency

  https://www.healthline.com/nutrition/vitamin-c-deficiency-symptoms

  Vitamin C deficiency is associated with poor immunity and a higher risk of infection, including serious illnesses like pneumonia. […] Signs of fatigue and poor mood can appear even with low-to-normal levels of vitamin C, but they quickly turn around with adequate vitamin C intake. […] As the deficiency progresses, bones may become brittle, nail and hair deformities can develop, wounds may take longer to heal and the immune system suffers.

• #1 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  Scurvy now primarily affects populations with limited access to nutritious food, such as people experiencing food insecurity, smokers, those with certain eating disorders, and individuals with malabsorption disorders or severe dietary restrictions. […] Even though my patient had all the signs and symptoms of scurvy, no one in the health care system recognized that he had been struggling with malnutrition for more than 30 years. […] The disease first showed itself in heaviness and weariness in all our limbs, such that we were all the time wanting to sleep and, having once sat down, were most reluctant to rise again. […] Although scurvy was mostly eradicated centuries ago, its simple cure is once again neglected today, in a system focused on making money with more complicated and costly diagnoses. […] This lack of nutrition testing creates a vicious cycle, where physicians do not recognize these conditions because they are not seeing the data in their patient populations, thus reinforcing the knowledge gap.

• #2 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

  Vitamin C plays many different roles in your body. A deficiency in the vitamin causes widespread symptoms. […] Typically, signs of scurvy begin after at least 4 weeks of severe, continual vitamin C deficiency. Generally, however, it takes 3 months or more for symptoms to develop. […] Early warning signs and symptoms of scurvy include: weakness, unexplained exhaustion, reduced appetite, irritability, aching legs. […] Common symptoms of untreated scurvy after 1 to 3 months include: anemia, when your blood lacks enough red blood cells or hemoglobin, gingivitis, which causes red, soft, and tender gums that bleed easily, skin hemorrhages, or bleeding under your skin, bruise-like raised bumps at your hair follicles often on your shins with central hairs that appear corkscrewed (twisted) and break easily, large areas of reddish-blue to black bruising, often on your legs and feet, tooth decay, tender, swollen joints, shortness of breath, chest pain, eye dryness, irritation, and hemorrhaging in the whites of your eyes (conjunctiva) or optic nerve, reduced wound healing and immune health, light sensitivity, blurred vision, mood swings often irritability and depression, gastrointestinal bleeding, headache.

• #2 Scurvy – Wikipedia

  https://en.wikipedia.org/wiki/Scurvy

  Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. […] Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding from the skin may occur. […] As scurvy worsens, there can be poor wound healing, personality changes, and finally death from infection or bleeding. […] Early symptoms are malaise and lethargy. After one to three months, patients develop shortness of breath and bone pain. […] Other symptoms include skin changes with roughness, easy bruising, and petechiae, gum disease, loosening of teeth, poor wound healing, and emotional changes (which may appear before any physical changes). […] In the late stages, jaundice, generalised edema, oliguria, neuropathy, fever, convulsions, and eventual death are frequently seen.

• #2 Scurvy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2567249/

  A 47-year-old male presented to the emergency department with a progressive onset of confusion, lethargy, anorexia, fatigue, weakness, and a diffuse nonpruritic perifollicular rash. […] Clinical manifestations of scurvy can be seen within 8 to 12 weeks of irregular or inadequate intake. Presentation can vary by individual. Early stages are often characterized by malaise, fatigue, and lethargy. One to 3 months of inadequate intake can lead to anemia, myalgia, bone pain, easy bruising, swelling, petechiae, perifollicular hemorrhages, corkscrew hairs, gum disease, poor wound healing, mood changes, and depression. […] Late stages of scurvy are more severe and life threatening; common manifestations include generalized edema, severe jaundice, hemolysis, acute spontaneous bleeding, neuropathy, fever, convulsions, and death.

• #2 How Would You Know If a Person Has Scurvy?

  https://www.medicinenet.com/how_would_you_know_if_a_person_has_scurvy/article.htm

  Scurvy is a severe vitamin C deficiency. Vitamin C is essential to maintaining connective tissue health. Without it, everything from your skin to your blood vessels can become weaker. […] Without treatment, scurvy can cause skin and joint problems, loss of teeth, and heart and lung issues. […] The early signs of scurvy might be mistaken for other health problems. Some early symptoms of scurvy include: Fatigue, Persistent irritability, Severe pain in your arms and legs, Swollen, bleeding gums, Unexplained bruising and skin discoloration. […] When scurvy goes untreated, the disease progresses. Advanced scurvy can cause serious problems, including: Bleeding in the joints, causing pain and difficulty walking, Persistent dry eyes, including stickiness and blurred vision, which can lead to bleeding from the optic nerve or conjunctiva, Anemia, Tooth loss due to gum damage, Heart and lung problems, such as low blood pressure or shortness of breath, which can lead to shock and death.

• #2 Vitamin C Deficiency – Nutritional Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-c-deficiency

  Symptoms of scurvy (related to defects in connective tissues) develop after a few months of deficiency. Follicular hyperkeratosis, coiled hair, and perifollicular hemorrhages may develop. Gums may become swollen, purple, spongy, and friable; they bleed easily in severe deficiency. Eventually, teeth become loose and avulsed. Secondary infections may develop. Wounds heal poorly and tear easily, and spontaneous hemorrhages may occur, especially as ecchymoses in the skin of the lower limbs or as bulbar conjunctival hemorrhage. […] In infants, symptoms include irritability, pain during movement, anorexia, and slowed growth. In infants and children, bone growth is impaired, and bleeding and anemia may occur. […] After weeks or months, the deficiency causes nonspecific symptoms (eg, weakness, lassitude, irritability, arthralgias, myalgias); later, connective tissue is affected, causing follicular hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages.

• #2 Scurvy: A Comprehensive Guide to Vitamin C Deficiency

  https://www.amritahospitals.org/kochi/blog/scurvy-what-you-need-to-know-to-identify-and-prevent-the-vitamin-c-deficiency

  Scurvy progresses gradually, with early signs often overlooked until the condition worsens. Symptoms can be divided into early-stage or primary-stage and advanced-stage manifestations. […] When the body lacks vitamin C for an extended period, typically 3 months or more, the symptoms of scurvy begin to appear. […] Primary Symptoms: Fatigue and weakness, swollen, bleeding gums, painful joints and muscles, easy bruising, slow wound healing, dry, rough skin, red spots on the skin or petechiae, corkscrew-shaped body hair. […] Advanced Symptoms: Depression and anxiety, severe joint pain, tooth loss, internal bleeding, poor wound healing, jaundice, fever, convulsions, anaemia. […] Scurvy is directly linked to a vitamin C deficiency, due to insufficient dietary intake or other factors affecting its absorption and utilisation.

• #2 Scurvy: Symptoms, Causes, Vitamin C Intake, and Treatment

  https://resources.healthgrades.com/right-care/food-nutrition-and-diet/scurvy

  Scurvy symptoms tend to develop a few weeks to months after having very low vitamin C levels. […] Initial symptoms of scurvy can include: tiredness, weakness, irritability or sadness, weight loss, joint or muscle aches or pain, leg pain. […] After a few months of low vitamin C, further symptoms may include: gums that are swollen, purple, spongy, or easily broken; bleeding gums and teeth falling out; hair becoming drier, brittle, and coiled when it wasn’t before; wounds that reopen or are slow to heal; random bleeding and easy bruising; pin-size spots on your skin that are red, purple, brown, or darkened; swelling in your legs or feet; decreased appetite; anemia, causing symptoms like shortness of breath, headache, and lightheadedness. […] Scurvy in infants and children may also cause: slowed growth, impaired bone growth, pain during movement. […] Scurvy is a group of symptoms that develop due to severe or prolonged vitamin C deficiency. It can cause symptoms like fatigue or weakness, slow wound healing, gum inflammation, and body pains.

• #2 Scurvy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2567249/

  Symptoms of fatigue, lethargy, pain, anorexia, and confusion improve within 24 hours of supplementation. Bruising, perifollicular hemorrhages, gingival bleeding, and weakness usually improve within 1 to 2 weeks. Corkscrew hairs regain normal appearance by 4 weeks. Complete recovery should be anticipated after approximately 3 months of regular vitamin C supplementation.

• #2 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  My patient came to me in agony. His hands and feet hurt, and had for many years, and his gums were swollen. […] I thought about his other symptomsfrequent bruising, severe dental disease, and poor wound healing. This was a textbook presentation of vitamin C deficiency. My patient had one of the oldest recorded ailments in human history: scurvy. […] Scurvy is a disease resulting from inadequate vitamin C intake for at least three months. While vitamin C deficiency can cause mild symptoms like fatigue, weakness, or irritability, scurvy occurs when a person does not consume adequate amounts of vitamin C necessary for metabolic function. Vitamin C, or ascorbic acid, is also essential for producing collagen, a protein crucial for repairing and maintaining skin, blood vessels, bones, and connective tissues. Without sufficient collagen, individuals with scurvy may experience symptoms such as loose teeth, joint pain, bruising, anemia, and slow wound-healing.

• #2 Vitamin C Deficiency: Signs and Symptoms

  https://www.health.com/vitamin-c-deficiency-symptoms-7568100

  Vitamin C deficiency can cause capillary (blood vessel) fragility, which contributes to the skin and hair symptoms mentioned above. […] Additionally, one of the roles of vitamin C is to repair and maintain bones and cartilage. Having scurvy means that your bones and cartilage are not getting enough vitamin C to grow and develop. […] Fatigue is an early sign of vitamin C deficiency; although, it is also an early sign of a variety of conditions and deficiencies. […] Vitamin C deficiency can also cause inflammation of the gums, called gingivitis. Gingivitis may cause your gums to bleed, swell, or appear red or purple. Bleeding gums are one of the most common symptoms of a vitamin C deficiency. […] Late-stage vitamin C deficiency can be life-threatening. If you are experiencing symptoms of scurvy, contact your healthcare provider.

• #2 Scurvy Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/scurvy

  Scurvy is a disease that occurs when you have a severe lack of vitamin C (ascorbic acid) in your diet. Scurvy causes general weakness, anemia, gum disease, poor wound healing, and skin hemorrhages. […] Scurvy is rare in the United States. Older adults who are not getting proper nutrition are most affected by scurvy.

• #2 Ahoy, Scurvy Awareness! – UF Health

  https://ufhealth.org/stories/2019/ahoy-scurvy-awareness

  Scurvy is caused by a vitamin C deficiency. […] The symptoms of scurvy including fatigue, loss of appetite and muscle pain are vague and can be associated with many other conditions. […] Some symptoms, like fatigue, can go away within the first day or so, but others can last longer.

• #3 Scurvy: Symptoms, causes, treatment, and prevention

  https://www.medicalnewstoday.com/articles/155758

  Scurvy symptoms and signs can include anemia, exhaustion, spontaneous bleeding, limb pain, swelling, and sometimes ulceration of the gums and loss of teeth. […] Symptoms of scurvy result from severe vitamin C deficiency. […] They include bleeding sores, tooth loss, anemia, and a reduced rate of healing for injuries. […] Vitamin C deficiency symptoms can appear after 8-12 weeks. Early signs include a loss of appetite, weight loss, fatigue, irritability, and lethargy. […] Within 1-3 months, there may be signs of anemia, myalgia, or pain, including bone pain, swelling, or edema, petechiae, or small red spots resulting from bleeding under the skin, corkscrew hairs, gum disease and loss of teeth, poor wound healing, shortness of breath, mood changes, and depression. […] In time, the person will show signs of generalized edema, severe jaundice, destruction of red blood cells, known as hemolysis, sudden and spontaneous bleeding, neuropathy, fever, and convulsions. It can be fatal. […] The symptoms of scurvy include anemia, fatigue, pain in the legs, swelling, and more.

• #3 Scurvy: Symptoms, Causes, Vitamin C Intake, and Treatment

  https://resources.healthgrades.com/right-care/food-nutrition-and-diet/scurvy

  Scurvy symptoms tend to develop a few weeks to months after having very low vitamin C levels. […] Initial symptoms of scurvy can include: tiredness, weakness, irritability or sadness, weight loss, joint or muscle aches or pain, leg pain. […] After a few months of low vitamin C, further symptoms may include: gums that are swollen, purple, spongy, or easily broken; bleeding gums and teeth falling out; hair becoming drier, brittle, and coiled when it wasn’t before; wounds that reopen or are slow to heal; random bleeding and easy bruising; pin-size spots on your skin that are red, purple, brown, or darkened; swelling in your legs or feet; decreased appetite; anemia, causing symptoms like shortness of breath, headache, and lightheadedness. […] Scurvy in infants and children may also cause: slowed growth, impaired bone growth, pain during movement. […] Scurvy is a group of symptoms that develop due to severe or prolonged vitamin C deficiency. It can cause symptoms like fatigue or weakness, slow wound healing, gum inflammation, and body pains.

• #3 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/125350-overview

  Scurvy is a state of dietary deficiency of vitamin C (ascorbic acid). The body’s pool of vitamin C can be depleted in 1-3 months. Signs and symptoms include fatigue, malaise, anemia, myalgia, bone pain, easy bruising, swelling, petechiae, gingivitis, perifollicular hemorrhages, corkscrew hairs, and poor wound healing. If left untreated, the disease can progress to jaundice, neuropathy, hemolysis, seizures, and death. […] The only effective therapy for scurvy is vitamin C replacement. Thus, the goal of treatment is to saturate the body rapidly with ascorbic acid; at maximum doses, body stores become saturated in a few days. With proper treatment, bleeding stops within 24 hours, and perifollicular petechiae resolve in 2 weeks. […] In advanced scurvy, serum bilirubin normalizes in less than 1 week, and anemia is corrected in less than a month.

• #3 Vitamin C Deficiency: Symptoms and Treatment

  https://patient.info/healthy-living/vitamin-c-deficiency-leaflet

  Persistent lack of dietary vitamin C in can lead to a condition called scurvy. Symptoms of scurvy include easy bruising, easy bleeding and joint and muscle pains. […] The first symptoms of vitamin C deficiency tend to be: Tiredness and weakness. Muscle and joint pains. Easy bruising. Spots that look like tiny, red-blue bruises on the skin. […] If not diagnosed and treated, vitamin C deficiency can also lead to shortness of breath, nerve problems, high temperature (fever) and fits (convulsions). Bleeding inside the brain and around the heart can cause death in some people with untreated vitamin C deficiency. However, this is extremely rare. […] People with vitamin C deficiency usually make a full recovery. Once treatment to replace vitamin C is started, symptoms usually quickly improve within days or weeks.

• #3 Scurvy | Pediatric Orthopaedic Society of North America (POSNA)

  https://posna.org/physician-education/study-guide/scurvy

  Patients may have petechiae, ecchymosis, bone pain, weakness, poor wound healing, and radiographic changes […] Children with scurvy are irritable, may have petechiae, ecchymosis, bone pain, weakness, and poor wound healing. Loss of appetite, irritability, and failure to thrive may be present. The gums become bluish and swollen and may hemorrhage. Because Vitamin C is essential to the structure of collagen, all body parts are affected. Vascular fragility is a major concern in these patients. Overall bone formation is reduced, and any bone that is formed lacks tensile strength. The limbs may be swollen, bruised and tender. In infants, pseudoparalysis may be present due to bone pain whereas older children may refuse to walk. […] Untreated, scurvy may result in failure to thrive, anemia, hypertension, and poor wound healing.

• #3 Vitamin C deficiency – Symptoms, diagnosis and treatment | BMJ Best Practice

  https://bestpractice.bmj.com/topics/en-gb/632

  Vitamin C deficiency can lead to scurvy, a potentially life-threatening condition. Though rare, scurvy has historically affected populations subject to famine or displacement, particularly during times of war. […] Most key clinical manifestations are related to impaired collagen synthesis. These include bleeding complications (spontaneous petechiae and ecchymoses), friable gingiva and loose teeth, bone pain, and joint effusions. […] Other complications of scurvy include heart failure, encephalopathy, and entrapment neuropathies. […] If not treated promptly, scurvy can be fatal. […] Cardinal features include spontaneous bleeding from gums or poor wound healing, perifollicular ecchymoses, haemarthroses, and joint pain. […] Diagnosis is often delayed because of slow identification of disease or incomplete review of dietary history. Rapid resolution occurs after vitamin C treatment.

• #3 What Is Scurvy? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/scurvy/

  Though the symptoms are unpleasant, scurvy is easily treated, and those who are treated recover quickly. […] Scurvy doesnt last long after vitamin C levels begin to bounce back. Most people will start feeling better within a day or two and will fully recover within a week, although some symptoms may take longer to clear up and should be monitored by your doctor.

• #3 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

  If left untreated, scurvy can cause life threatening conditions. […] Untreated scurvy can be a life threatening condition and cause death. […] Most people begin to recover from scurvy fairly quickly after starting treatment. You should see an improvement in some symptoms within 1 to 2 days of treatment, including: pain, exhaustion, confusion, headache, mood swings. […] Other symptoms may take a few weeks to improve following treatment, including: weakness, bleeding, bruising, jaundice. […] If left untreated, chronic scurvy can cause serious health complications.

• #3 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency

  Severe deficiency, called scurvy, causes bruising, gum and dental problems, dry hair and skin, and anemia. […] The symptoms of scurvy develop after a few months of deficiency. Bleeding may occur under the skin (particularly around hair follicles or as bruises), around the gums, and into the joints. The gums become swollen, purple, and spongy. The teeth eventually loosen. The hair becomes dry, brittle, and coiled (like a corkscrew), and the skin becomes dry, rough, and scaly. Fluid may accumulate in the legs. Anemia may develop. Infections may develop, and wounds do not heal. […] Scurvy is treated with high doses of daily vitamin C (ascorbic acid) supplements, followed by a nutritious diet that supplies 1 to 2 times the daily recommended amount of vitamin C. Most symptoms disappear after 1 to 2 weeks. Gum problems may last longer.

• #3 SCURVY (VITAMIN C DEFICIENCY) – Symptoms, Causes, Risk Factors and Treatment – Ecosh

  https://ecosh.com/scurvy-vitamin-c-deficiency-symptoms-causes-risk-factors-and-treatment/

  Scurvy is a disease, which is caused by a long-term deficiency of vitamin C (ascorbic acid). […] Symptoms of Scurvy may start to appear after 8 to 12 weeks. […] Early stages have often symptoms such as: Malaise, Fatigue, Lethargy. […] One to three months of insufficient intake of vitamin C can lead to health conditions such as: Anemia, Myalgia, Bone pain, Easy bruising, Swelling, Petechiae, Easy bruising and perifollicular hemorrhages, Corkscrew hairs, Gum disease, Poor wound healing, Mood changes, Depression. […] Late stages of scurvy are more serious and life threatening, general signs include: Generalized edema, Severe jaundice, Hemolysis, Acute spontaneous bleeding, Neuropathy, Fever, Convulsions, Death. […] Some symptoms such as fatigue, lethargy, pain, anorexia, and confusion should improve within 24 hours of supplementation. Other symptoms like bruising, perifollicular hemorrhages, gingival bleeding, and weakness usually take 1 to 2 weeks to improve. […] However, complete recovery is generally anticipated after about 3 months of regular ascorbic acid supplementation.

• #3

  https://journals.lww.com/acgcr/fulltext/2020/07000/vitamin_c_deficiency__an_under_recognized.6.aspx

  Scurvy manifests clinically because vitamin C is a reducing agent or cofactor, playing a central role in collagen synthesis, prostaglandin and prostacyclin metabolism, reduction of free radicals, and iron absorption. […] Scurvy is ultimately a clinical diagnosis. However, serum vitamin C levels below 20 mol/L—less than 11.4 in the case of severe deficiency, as was seen in our patient—can support the diagnosis. […] Notably, treatment with supplementation results in rapid resolution of symptoms within weeks. […] Because CD carries marked morbidity and complications, identifying vitamin C deficiency is low-hanging fruit that can lead to rapid resolution of symptoms.

• #3 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  Scurvy now primarily affects populations with limited access to nutritious food, such as people experiencing food insecurity, smokers, those with certain eating disorders, and individuals with malabsorption disorders or severe dietary restrictions. […] Even though my patient had all the signs and symptoms of scurvy, no one in the health care system recognized that he had been struggling with malnutrition for more than 30 years. […] The disease first showed itself in heaviness and weariness in all our limbs, such that we were all the time wanting to sleep and, having once sat down, were most reluctant to rise again. […] Although scurvy was mostly eradicated centuries ago, its simple cure is once again neglected today, in a system focused on making money with more complicated and costly diagnoses. […] This lack of nutrition testing creates a vicious cycle, where physicians do not recognize these conditions because they are not seeing the data in their patient populations, thus reinforcing the knowledge gap.

• #4 Scurvy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2567249/

  A 47-year-old male presented to the emergency department with a progressive onset of confusion, lethargy, anorexia, fatigue, weakness, and a diffuse nonpruritic perifollicular rash. […] Clinical manifestations of scurvy can be seen within 8 to 12 weeks of irregular or inadequate intake. Presentation can vary by individual. Early stages are often characterized by malaise, fatigue, and lethargy. One to 3 months of inadequate intake can lead to anemia, myalgia, bone pain, easy bruising, swelling, petechiae, perifollicular hemorrhages, corkscrew hairs, gum disease, poor wound healing, mood changes, and depression. […] Late stages of scurvy are more severe and life threatening; common manifestations include generalized edema, severe jaundice, hemolysis, acute spontaneous bleeding, neuropathy, fever, convulsions, and death.

• #4 Scurvy: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24318-scurvy

  The first symptoms of scurvy may develop after a few months of vitamin C deficiency. Symptoms of scurvy range from fatigue to bleeding gums. […] Scurvy symptoms may start to develop after a few months of not getting enough vitamin C in your diet. The first symptoms may include general weakness, fatigue, irritability and joint pain. […] If left untreated, more severe symptoms may start to develop. These may include: Anemia. Swollen, bleeding gums that may become purple and spongy. Loosened teeth that may fall out. Bleeding under your skin (skin hemorrhages). You may develop a scurvy rash that shows up as red or blue spots on your skin. Easily bruised skin. Rough, scaly skin. Swollen legs. Opening of previously healed wounds and new wounds that dont heal. Dry, brittle hair that coils like a corkscrew.

• #4 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Splinter haemorrhages in the nails. […] Red, swollen gums in patients with teeth (particularly around the upper incisors) which may later become purple or black. […] Bleeding from the gums. […] Loosening and loss of teeth. […] Painful haemarthosis. […] Subperiosteal haemorrhage, particularly femur and proximal tibia. […] Costochondral junction beading scorbutic rosary. […] Intramuscular bleeding leading to woody oedema. […] Severe pain of arms and legs (the major feature of scurvy in infants) and reluctance to walk. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #4 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

  Vitamin C plays many different roles in your body. A deficiency in the vitamin causes widespread symptoms. […] Typically, signs of scurvy begin after at least 4 weeks of severe, continual vitamin C deficiency. Generally, however, it takes 3 months or more for symptoms to develop. […] Early warning signs and symptoms of scurvy include: weakness, unexplained exhaustion, reduced appetite, irritability, aching legs. […] Common symptoms of untreated scurvy after 1 to 3 months include: anemia, when your blood lacks enough red blood cells or hemoglobin, gingivitis, which causes red, soft, and tender gums that bleed easily, skin hemorrhages, or bleeding under your skin, bruise-like raised bumps at your hair follicles often on your shins with central hairs that appear corkscrewed (twisted) and break easily, large areas of reddish-blue to black bruising, often on your legs and feet, tooth decay, tender, swollen joints, shortness of breath, chest pain, eye dryness, irritation, and hemorrhaging in the whites of your eyes (conjunctiva) or optic nerve, reduced wound healing and immune health, light sensitivity, blurred vision, mood swings often irritability and depression, gastrointestinal bleeding, headache.

• #4 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More

  https://www.healthline.com/health/scurvy

  If left untreated, scurvy can cause life threatening conditions. […] Untreated scurvy can be a life threatening condition and cause death. […] Most people begin to recover from scurvy fairly quickly after starting treatment. You should see an improvement in some symptoms within 1 to 2 days of treatment, including: pain, exhaustion, confusion, headache, mood swings. […] Other symptoms may take a few weeks to improve following treatment, including: weakness, bleeding, bruising, jaundice. […] If left untreated, chronic scurvy can cause serious health complications.

• #4 Scurvy | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/scurvy/

  Even though the number of people suffering from Scurvy has largely come down, poor diet or eating habits can lead to Scurvy. In an adult generally, the symptoms of scurvy include: […] Joint pain, particularly in legs […] Weakness or fatigue […] Red spots on skin […] Swelling in wounds […] In infants, there might be different symptoms that could help in detection of the disease, such as: […] High fever […] Diarrhea […] Irritability […] Loss of appetite.

• #4 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  My patient came to me in agony. His hands and feet hurt, and had for many years, and his gums were swollen. […] I thought about his other symptomsfrequent bruising, severe dental disease, and poor wound healing. This was a textbook presentation of vitamin C deficiency. My patient had one of the oldest recorded ailments in human history: scurvy. […] Scurvy is a disease resulting from inadequate vitamin C intake for at least three months. While vitamin C deficiency can cause mild symptoms like fatigue, weakness, or irritability, scurvy occurs when a person does not consume adequate amounts of vitamin C necessary for metabolic function. Vitamin C, or ascorbic acid, is also essential for producing collagen, a protein crucial for repairing and maintaining skin, blood vessels, bones, and connective tissues. Without sufficient collagen, individuals with scurvy may experience symptoms such as loose teeth, joint pain, bruising, anemia, and slow wound-healing.

• #4 The British 'Limeys’ Were Right: A Short History of Scurvy | Health.mil

  https://health.mil/News/Articles/2022/01/10/The-British-Limeys-Were-Right-A-Short-History-of-Scurvy

  Scurvy is a dietary deficiency caused by a lack of vitamin C. The symptoms of scurvy are dramatic and terrible. In his 1820 textbook on nautical medicine, Navy surgeon Usher Parsons unflinchingly described the signs: […] „The gums become soft, livid and swollen, are apt to bleed from the slightest cause, and separate from the teeth, leaving them loose. About the same time the legs swell, are glossy, and soon exhibit foul ulcers. The same appearances follow, on other depending parts of the body. At first the ulcers resemble black blisters which spread and discharge a dark colored matter. These ulcers increase. Emaciation ensues. Bleeding occurs at the nose and mouth. All the evacuations from the body become intolerably fetid. Death closes the scene.” […] Today, scurvy still occurs in developed countries despite the widespread availability of multiple enriched and fortified foods.

• #5 Scurvy (Vitamin C Deficiency) Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/125350-clinical

  Symptoms and signs of scurvy may be remembered by the 4 Hs: hemorrhage, hyperkeratosis, hypochondriasis, and hematologic abnormalities. […] The initial symptoms of scurvy are nonspecific and include the following: malaise, lethargy, loss of appetite, peevishness (ill-tempered), poor weight gain, diarrhea, tachypnea, and fever. […] After 1-3 months of severe or total vitamin C deficiency, patients develop shortness of breath and bone pain. Myalgias may occur because of reduced carnitine production. Skin changes with roughness, easy bruising and petechiae, gum disease, loosening of teeth, poor wound healing, and emotional changes occur. […] In the late stages, jaundice, generalized edema, oliguria, neuropathy, fever, and convulsions can be seen. Left untreated, scurvy progresses, with potentially fatal complications, including cerebral hemorrhage or hemopericardium.

• #5 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Scurvy (scorbutus) is the clinical disease caused by Vitamin C (ascorbic acid) deficiency with characteristic mucocutaneous and musculoskeletal manifestations. […] The initial clinical features of scurvy are non-specific and include: General malaise and lethargy, Poor appetite and failure to thrive, Ill temper, Fever and tachypnoea. […] As the condition progresses, shortness of breath, wasting, anaemia, oedema, mucocutaneous changes, ocular and musculoskeletal symptoms develop. […] Follicular hyperkeratotic papules appear first on the upper arms, often spreading to the legs and buttocks. […] Perifollicular haemorrhages, purpura (which can be palpable), and ecchymoses on the legs. […] Hairs are often twisted and fragile (corkscrew hairs, swan-neck hairs). […] Poor wound healing and re-opening of old healed scars.

• #5 Scurvy? Symptoms, Causes and Treatments

  https://www.webmd.com/skin-problems-and-treatments/what-to-know-scurvy

  Scurvy is a progressive disease; the longer it’s left untreated, the more symptoms you’ll have. Some of the most common symptoms include: […] Lethargy, along with body weakness, can be so intense that you’re unable to get out of bed. It’s usually the first symptom to appear. This led to the common belief that scurvy was actually caused by laziness. […] Aches are felt primarily in the joints, but they aren’t limited there. It may feel similar to body aches from the flu. […] Noticeable swelling happens mostly in your arms and legs. […] The slightest touch will cause bruising. Internal bleeding will cause your skin to look splotchy. […] Your gums turn spongy and porous. Your breath will smell rotten, and your teeth may start to loosen in their sockets. […] There isn’t enough collagen left in your body to continue creating scar tissue, so old wounds may start opening. Mucous membranes (which include your lips, mouth, nasal passages, and middle ear) may also bleed.

• #5 Scurvy: Symptoms, causes, treatment, and prevention

  https://www.medicalnewstoday.com/articles/155758

  Scurvy symptoms and signs can include anemia, exhaustion, spontaneous bleeding, limb pain, swelling, and sometimes ulceration of the gums and loss of teeth. […] Symptoms of scurvy result from severe vitamin C deficiency. […] They include bleeding sores, tooth loss, anemia, and a reduced rate of healing for injuries. […] Vitamin C deficiency symptoms can appear after 8-12 weeks. Early signs include a loss of appetite, weight loss, fatigue, irritability, and lethargy. […] Within 1-3 months, there may be signs of anemia, myalgia, or pain, including bone pain, swelling, or edema, petechiae, or small red spots resulting from bleeding under the skin, corkscrew hairs, gum disease and loss of teeth, poor wound healing, shortness of breath, mood changes, and depression. […] In time, the person will show signs of generalized edema, severe jaundice, destruction of red blood cells, known as hemolysis, sudden and spontaneous bleeding, neuropathy, fever, and convulsions. It can be fatal. […] The symptoms of scurvy include anemia, fatigue, pain in the legs, swelling, and more.

• #5 Scurvy: Symptoms, Causes, Vitamin C Intake, and Treatment

  https://resources.healthgrades.com/right-care/food-nutrition-and-diet/scurvy

  Scurvy symptoms tend to develop a few weeks to months after having very low vitamin C levels. […] Initial symptoms of scurvy can include: tiredness, weakness, irritability or sadness, weight loss, joint or muscle aches or pain, leg pain. […] After a few months of low vitamin C, further symptoms may include: gums that are swollen, purple, spongy, or easily broken; bleeding gums and teeth falling out; hair becoming drier, brittle, and coiled when it wasn’t before; wounds that reopen or are slow to heal; random bleeding and easy bruising; pin-size spots on your skin that are red, purple, brown, or darkened; swelling in your legs or feet; decreased appetite; anemia, causing symptoms like shortness of breath, headache, and lightheadedness. […] Scurvy in infants and children may also cause: slowed growth, impaired bone growth, pain during movement. […] Scurvy is a group of symptoms that develop due to severe or prolonged vitamin C deficiency. It can cause symptoms like fatigue or weakness, slow wound healing, gum inflammation, and body pains.

• #5

  https://journals.lww.com/acgcr/fulltext/2020/07000/vitamin_c_deficiency__an_under_recognized.6.aspx

  Scurvy manifests clinically because vitamin C is a reducing agent or cofactor, playing a central role in collagen synthesis, prostaglandin and prostacyclin metabolism, reduction of free radicals, and iron absorption. […] Scurvy is ultimately a clinical diagnosis. However, serum vitamin C levels below 20 mol/L—less than 11.4 in the case of severe deficiency, as was seen in our patient—can support the diagnosis. […] Notably, treatment with supplementation results in rapid resolution of symptoms within weeks. […] Because CD carries marked morbidity and complications, identifying vitamin C deficiency is low-hanging fruit that can lead to rapid resolution of symptoms.

• #5

  https://journals.lww.com/acgcr/fulltext/2020/07000/vitamin_c_deficiency__an_under_recognized.6.aspx

  Although many nutritional deficiencies are associated with Crohn’s disease (CD), vitamin C deficiency is less frequently diagnosed and reported despite its prevalence. […] Identification of the deficiency is vital, however, because treatment can lead to swift, marked resolution of symptoms. […] A few small studies have reported the prevalence of inadequate vitamin C intake and low serum vitamin C levels in patients with CD. […] In CD, scurvy is believed to arise primarily from insufficient consumption and malabsorption of vitamin C. […] The sequelae of vitamin C deficiency can masquerade as active CD itself and include arthralgias, anemia, fatigue, edema, oral ulcers, bleeding, and poor wound healing. […] More specific symptoms include follicular hyperkeratosis, perifollicular hemorrhage, and gingivitis, which was seen in our patient.

• #6 Scurvy

  https://www.nhs.uk/conditions/scurvy/

  Symptoms of scurvy may include: […] feel very tired and weak all the time […] feel irritable and sad all the time […] have joint, muscle or leg pain […] have wounds that reopen or are not healing well […] skin that bruises easily […] swollen, bleeding gums (sometimes teeth can fall out) […] developing red or blue spots on the skin, usually on the legs and feet, although this may be less noticeable on brown or black skin. […] It’s important that scurvy is treated quickly. Without treatment, scurvy can cause serious problems and may even be life-threatening.

• #6 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Splinter haemorrhages in the nails. […] Red, swollen gums in patients with teeth (particularly around the upper incisors) which may later become purple or black. […] Bleeding from the gums. […] Loosening and loss of teeth. […] Painful haemarthosis. […] Subperiosteal haemorrhage, particularly femur and proximal tibia. […] Costochondral junction beading scorbutic rosary. […] Intramuscular bleeding leading to woody oedema. […] Severe pain of arms and legs (the major feature of scurvy in infants) and reluctance to walk. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #6 Vitamin C Deficiency – Nutritional Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-c-deficiency

  Symptoms of scurvy (related to defects in connective tissues) develop after a few months of deficiency. Follicular hyperkeratosis, coiled hair, and perifollicular hemorrhages may develop. Gums may become swollen, purple, spongy, and friable; they bleed easily in severe deficiency. Eventually, teeth become loose and avulsed. Secondary infections may develop. Wounds heal poorly and tear easily, and spontaneous hemorrhages may occur, especially as ecchymoses in the skin of the lower limbs or as bulbar conjunctival hemorrhage. […] In infants, symptoms include irritability, pain during movement, anorexia, and slowed growth. In infants and children, bone growth is impaired, and bleeding and anemia may occur. […] After weeks or months, the deficiency causes nonspecific symptoms (eg, weakness, lassitude, irritability, arthralgias, myalgias); later, connective tissue is affected, causing follicular hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages.

• #6

  https://www.orthobullets.com/basic-science/9034/scurvy

  Scurvy is disease caused by severe Vitamin C deficiency which presents with joint effusions, swelling over long bones, bleeding gums, loosening of teeth, hematuria, and susceptibility to hemorrhage. […] Symptoms include malaise and fatigue, bone pain, myalgia, gum bleeding and loosening of teeth, hematuria, hematemesis, hemorrhage, and iron deficiency. […] Physical exam may reveal petechiae and ecchymosis, joint effusions, swelling over long bones because of subperiosteal hemorrhage, and scorbutic rosary (costochondral separation). […] The diagnosis is usually made based on history, clinical and radiological picture, and resolution of symptoms following vitamin C administration. Lab tests are usually not helpful. […] Excellent prognosis if treated early.

• #6 Vitamin C Deficiency: Symptoms and Treatment

  https://patient.info/healthy-living/vitamin-c-deficiency-leaflet

  Persistent lack of dietary vitamin C in can lead to a condition called scurvy. Symptoms of scurvy include easy bruising, easy bleeding and joint and muscle pains. […] The first symptoms of vitamin C deficiency tend to be: Tiredness and weakness. Muscle and joint pains. Easy bruising. Spots that look like tiny, red-blue bruises on the skin. […] If not diagnosed and treated, vitamin C deficiency can also lead to shortness of breath, nerve problems, high temperature (fever) and fits (convulsions). Bleeding inside the brain and around the heart can cause death in some people with untreated vitamin C deficiency. However, this is extremely rare. […] People with vitamin C deficiency usually make a full recovery. Once treatment to replace vitamin C is started, symptoms usually quickly improve within days or weeks.

• #6 How Would You Know If a Person Has Scurvy?

  https://www.medicinenet.com/how_would_you_know_if_a_person_has_scurvy/article.htm

  Scurvy is a severe vitamin C deficiency. Vitamin C is essential to maintaining connective tissue health. Without it, everything from your skin to your blood vessels can become weaker. […] Without treatment, scurvy can cause skin and joint problems, loss of teeth, and heart and lung issues. […] The early signs of scurvy might be mistaken for other health problems. Some early symptoms of scurvy include: Fatigue, Persistent irritability, Severe pain in your arms and legs, Swollen, bleeding gums, Unexplained bruising and skin discoloration. […] When scurvy goes untreated, the disease progresses. Advanced scurvy can cause serious problems, including: Bleeding in the joints, causing pain and difficulty walking, Persistent dry eyes, including stickiness and blurred vision, which can lead to bleeding from the optic nerve or conjunctiva, Anemia, Tooth loss due to gum damage, Heart and lung problems, such as low blood pressure or shortness of breath, which can lead to shock and death.

• #6 Vitamin C (Ascorbic Acid) Deficiency and Excess Mnemonic for USMLE

  https://pixorize.com/view/3745

  SummaryVitamin C (Ascorbic Acid) imbalances can occur as either deficiency or excess. Deficiency of Vitamin C results in the clinical syndrome of scurvy. Symptoms include easy bleeding, swollen gums, weakened immune response, anemia, and coiled or “corkscrew” hairs. The bleeding abnormalities can manifest as bruising, petechiae, hemarthrosis, subperiosteal and perifollicular hemorrhages. […] Clinical syndrome of scurvy […] impaired collagen synthesis weakens vascular beds […] subperiosteal hemorrhages […] hemarthrosis(bleeding into joint spaces) […] swollen, painful gums […] bruising, petechiae, and perifollicular hemorrhages […] poor wound healing […] weakened immune response […] anemia, coiled “corkscrew” hair also seen.

• #7 Vitamin C Deficiency – Nutritional Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-c-deficiency

  Symptoms of scurvy (related to defects in connective tissues) develop after a few months of deficiency. Follicular hyperkeratosis, coiled hair, and perifollicular hemorrhages may develop. Gums may become swollen, purple, spongy, and friable; they bleed easily in severe deficiency. Eventually, teeth become loose and avulsed. Secondary infections may develop. Wounds heal poorly and tear easily, and spontaneous hemorrhages may occur, especially as ecchymoses in the skin of the lower limbs or as bulbar conjunctival hemorrhage. […] In infants, symptoms include irritability, pain during movement, anorexia, and slowed growth. In infants and children, bone growth is impaired, and bleeding and anemia may occur. […] After weeks or months, the deficiency causes nonspecific symptoms (eg, weakness, lassitude, irritability, arthralgias, myalgias); later, connective tissue is affected, causing follicular hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages.

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