Szkorbut
Etiologia i przyczyny

Szkorbut jest chorobą wynikającą z istotnego niedoboru witaminy C (kwasu askorbinowego), której zapasy w organizmie mogą wyczerpać się po 1-3 miesiącach braku odpowiedniej podaży. Witamina C jest niezbędna do syntezy kolagenu, kluczowego białka tkanki łącznej, a jej deficyt prowadzi do zaburzeń strukturalnych skóry, naczyń krwionośnych, kości i innych tkanek. Objawy kliniczne pojawiają się zwykle po 4-12 tygodniach niedoboru i obejmują m.in. osłabienie, krwawienia, anemię wynikającą z upośledzonego wchłaniania żelaza oraz zaburzenia gojenia ran. Czynniki ryzyka to m.in. diety ubogie w świeże owoce i warzywa, choroby przewodu pokarmowego (np. choroba Leśniowskiego-Crohna), uzależnienia, palenie tytoniu (obniżające poziom witaminy C o 33%), dializy, stany zapalne, ciąża, laktacja oraz stany zwiększonego zapotrzebowania metabolicznego. Warto podkreślić, że witamina C ulega degradacji podczas obróbki termicznej, co może dodatkowo obniżać jej dostępność w diecie.

Etiologia szkorbutu (gnilca)

Szkorbut (gnilec) jest chorobą spowodowaną znacznym niedoborem witaminy C (kwasu askorbinowego) w organizmie. Główną przyczyną tej choroby jest niedostateczne spożycie witaminy C w diecie przez dłuższy okres, zazwyczaj od 1 do 3 miesięcy.123 Zdrowy organizm nie jest w stanie samodzielnie syntetyzować witaminy C, co sprawia, że podaż tego składnika odżywczego musi pochodzić wyłącznie z pożywienia lub suplementów.45

Przyczyny pierwotne

Niedobór witaminy C jest pierwotną przyczyną szkorbutu, najczęściej wynikającą z nieprawidłowej diety. Witamina C występuje głównie w świeżych owocach i warzywach, dlatego dieta uboga w te produkty znacząco zwiększa ryzyko rozwoju choroby.67 Całkowity zapas witaminy C w organizmie może ulec wyczerpaniu w ciągu 1-3 miesięcy przy braku odpowiedniego spożycia.8 Objawy szkorbutu pojawiają się zazwyczaj po 4-12 tygodniach niewystarczającego przyjmowania witaminy C.9

Istotnym czynnikiem jest również fakt, że witamina C ulega zniszczeniu podczas obróbki termicznej i konserwowania żywności. Gotowanie, szczególnie długotrwałe, niszczy znaczną część witaminy C zawartej w produktach spożywczych, co może prowadzić do niewystarczającej podaży tego składnika, nawet przy pozornie zbilansowanej diecie.1011

Rola fizjologiczna witaminy C

Witamina C pełni kluczową rolę w syntezie kolagenu, podstawowego białka strukturalnego w organizmie. Kolagen jest głównym składnikiem tkanki łącznej, skóry, naczyń krwionośnych, ścięgien, więzadeł, kości i chrząstek, stanowiąc około 30% białek w ludzkim ciele.1213 Niedobór witaminy C prowadzi do upośledzenia syntezy kolagenu, co skutkuje zaburzeniami w formowaniu i utrzymaniu struktury tkanek łącznych.14

Witamina C odgrywa również istotną rolę w procesach antyoksydacyjnych, redukcji wolnych rodników, metabolizmie lipidów, a także wpływa na zdrowie układu sercowo-naczyniowego. Ponadto jest niezbędna do prawidłowego wchłaniania żelaza w proksymalnym odcinku jelita cienkiego, co tłumaczy często występującą anemię u pacjentów ze szkorbutem.1516

Grupy ryzyka

Istnieje kilka grup szczególnie narażonych na rozwój szkorbutu:

  • Osoby starsze, zwłaszcza mężczyźni żyjący samotnie, u których dieta może być niewystarczająco zróżnicowana1718
  • Osoby z chorobami przewodu pokarmowego, takimi jak choroba Leśniowskiego-Crohna, wrzodziejące zapalenie jelita grubego, zespół jelita drażliwego, które mogą upośledzać wchłanianie witaminy C1920
  • Osoby z uzależnieniem od alkoholu lub narkotyków, które często mają niedobory żywieniowe2122
  • Osoby stosujące diety restrykcyjne, w tym diety ketogeniczne, oraz osoby z alergiami pokarmowymi2324
  • Osoby palące papierosy – palenie zmniejsza poziom witaminy C we krwi nawet o 33%2526
  • Osoby poddawane dializom, chemioterapii lub radioterapii2728
  • Dzieci z zaburzeniami odżywiania, takimi jak ARFID (avoidant/restrictive food intake disorder) czy anoreksja2930
  • Osoby z nadczynnością tarczycy3132
  • Kobiety w ciąży i karmiące piersią, ze względu na zwiększone zapotrzebowanie na witaminę C3334
  • Osoby z niskim statusem socjoekonomicznym, mające ograniczony dostęp do świeżych owoców i warzyw3536
  • Dzieci z zaburzeniami ze spektrum autyzmu, które mogą mieć bardzo wybiórczą dietę3738
  • Osoby z nadmiarem żelaza wtórnym do chorób hematologicznych, takich jak talasemia czy anemia sierpowata39

Czynniki genetyczne

Interesującym aspektem etiologii szkorbutu jest podłoże genetyczne. W przeciwieństwie do większości ssaków, ludzie nie są w stanie syntetyzować witaminy C z powodu braku lub defektu genu kontrolującego syntezę enzymu L-gulonolaktonooksydazy. Ten defekt genetyczny pojawił się w toku ewolucji na skutek mutacji warunkowej letalnej.4041 Z tego powodu ludzie, podobnie jak niektóre inne ssaki (np. świnki morskie, nietoperze owocożerne i niektóre naczelne), są całkowicie zależni od dostarczania witaminy C z zewnątrz.42

Stany zwiększonego zapotrzebowania na witaminę C

Niektóre stany fizjologiczne i patologiczne znacząco zwiększają zapotrzebowanie organizmu na witaminę C, podnosząc ryzyko rozwoju szkorbutu nawet przy pozornie wystarczającej podaży tego składnika w diecie:

  • Ciąża i laktacja – zwiększone zapotrzebowanie na składniki odżywcze43
  • Choroby przebiegające z wysoką gorączką i stanami zapalnymi4445
  • Nadczynność tarczycy46
  • Przewlekła biegunka47
  • Stan po zabiegach chirurgicznych i oparzeniach4849
  • Nowotwory – mogą zwiększać wykorzystanie witaminy C do neutralizacji nadtlenków lipidów lub sekwestracji witaminy C przez komórki nowotworowe50

Zaburzenia wchłaniania

Oprócz niedostatecznej podaży z dietą, szkorbut może wynikać z zaburzeń wchłaniania witaminy C. Badania wykazały, że żelazo jest istotne w absorpcji witaminy C, a niedobór żelaza może obniżać ekspresję transportera witaminy C zależnego od sodu w komórkach jelitowych, prowadząc do jej niedoboru.51 Ponadto, choroby zapalne jelit, takie jak choroba Leśniowskiego-Crohna czy wrzodziejące zapalenie jelita grubego, mogą znacząco upośledzać wchłanianie składników odżywczych, w tym witaminy C.5253

Osoby poddawane dializom również są narażone na niedobór witaminy C ze względu na jej zwiększone usuwanie z organizmu podczas zabiegu filtracji.54 Podobnie, stosowanie inhibitorów pompy protonowej lub glikokortykosteroidów przez dłuższy czas może wpływać na wchłanianie witaminy C, prowadząc do jej niedoboru.55

Aspekty socjoekonomiczne szkorbutu

Mimo że szkorbut jest obecnie rzadki w krajach rozwiniętych, nadal występuje w pewnych populacjach. W ostatnich latach odnotowano nawet wzrost liczby przypadków szkorbutu w niektórych regionach, co wiąże się głównie z czynnikami socjoekonomicznymi.5657

Badanie przeprowadzone we Francji wykazało znaczący wzrost liczby przypadków szkorbutu i ciężkiego niedożywienia wśród dzieci, powiązany ze wzrostem cen żywności. Inflacja cen żywności osiągnęła 15% w styczniu 2023 roku, co było ponad dwukrotnie wyższe niż ogólna stopa inflacji. Rodziny o niskich dochodach nie mogły sobie pozwolić na zakup produktów bogatych w witaminę C, takich jak świeże owoce i warzywa.58

Szkorbut dotyka również populacje uchodźców całkowicie zależnych od pomocy żywnościowej oraz osób w regionach dotkniętych klęskami żywiołowymi czy konfliktami, gdzie dostęp do świeżej żywności jest ograniczony.5960

Podsumowanie etiologii szkorbutu

Szkorbut jest chorobą spowodowaną niedoborem witaminy C, której główną przyczyną jest niedostateczne spożycie świeżych owoców i warzyw. Z powodu niezdolności organizmu ludzkiego do samodzielnej syntezy witaminy C, jesteśmy całkowicie zależni od jej dostarczania z dietą. Niedobór witaminy C prowadzi do upośledzenia syntezy kolagenu, co skutkuje szeregiem objawów klinicznych charakterystycznych dla szkorbutu.6162

Choć w przeszłości szkorbut był kojarzony głównie z długimi podróżami morskimi, obecnie występuje przede wszystkim u osób niedożywionych, stosujących restrykcyjne diety, uzależnionych od alkoholu i narkotyków, a także u osób z chorobami przewodu pokarmowego upośledzającymi wchłanianie składników odżywczych. Warto podkreślić, że szkorbut można skutecznie leczyć poprzez suplementację witaminy C oraz wprowadzenie zbilansowanej diety bogatej w świeże owoce i warzywa.6364

Wzrost liczby przypadków szkorbutu w niektórych populacjach, zwłaszcza wśród dzieci z rodzin o niskich dochodach, wskazuje na potrzebę intensyfikacji programów pomocy żywnościowej i społecznej w celu zmniejszenia niedożywienia i braku bezpieczeństwa żywnościowego.65

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  1. 12.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Scurvy: Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/24318-scurvy
    Scurvy is a disease caused by a serious vitamin C deficiency. Not eating enough fruits and vegetables is the main cause of the disease. […] Scurvy is a disease caused by a significant lack of vitamin C in your diet. The medical definition of scurvy is severe vitamin C (ascorbic acid) deficiency. […] Vitamin C deficiency can occur due to a diet low in vitamin C. But a deficiency severe enough to cause scurvy is rare in the U.S. because most people get enough of the nutrient in their diet. […] A severe lack of vitamin C in your diet for at least three months can cause scurvy. Reasons for this deficiency include not eating enough fresh fruits and vegetables. Also, cooking destroys some of the vitamin C found in food. […] Scurvy treatment is essential to avoid further complications. The condition is easily treatable by consuming more vitamin C.
  • #2 Vitamin C Deficiency – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK493187/
    Scurvy is a clinical syndrome resulting from vitamin C deficiency. […] The primary cause of vitamin C deficiency is due to inadequate nutritional intake. […] Vitamin C is naturally present in various fruits and vegetables, such as citrus fruits, potatoes, spinach, broccoli, red peppers, strawberries, and tomatoes. […] Symptoms of scurvy appear within 4 to 12 weeks of insufficient vitamin C intake. […] Several factors can contribute to an increased risk of vitamin C deficiency, some of which are listed below. […] In summary, a range of factors can significantly heighten the risk of vitamin C deficiency. […] Vitamin C deficiency affects millions of individuals globally. […] Scurvy arises due to inadequate vitamin C intake, which is critical in synthesizing collagen. […] Vitamin C deficiency compromises immune function, rendering individuals more susceptible to infections and causing delays in wound healing. […] The complications associated with vitamin C treatment for scurvy are relatively infrequent, generally mild, and often associated with dosage.
  • #3 Scurvy: Symptoms, Causes, Diagnosis, Treatment, and Prevention
    https://www.verywellhealth.com/what-is-scurvy-401331
    Scurvy, a potentially fatal medical condition caused by vitamin C deficiency, is not common. […] Historically, scurvy was considered to be a disease that affected sailors. This is because fruits, which are rich in vitamin C, were inaccessible on long voyages. The vitamin C stored in your body becomes depleted over the course of one to three months. […] Scurvy is most common in developing countries where malnutrition is endemic, but it may occur in developed countries as well. There are several predisposing factors that are associated with an increased risk of scurvy. […] Vitamin C is needed for the formation of collagen, a protein that makes up connective tissues in your body like skin, blood vessels, tendons, ligaments, bones, and cartilage. […] A diet that is lacking in fresh fruits and vegetables can increase your chances of developing scurvy. […] If your diet seems to include an adequate amount of these foods, then your medical team may look to other causes of low vitamin C, such as gastrointestinal conditions that result in malabsorption.
  • #4 Scurvy (vitamin C deficiency)
    https://dermnetnz.org/topics/scurvy
    Scurvy develops when sustained dietary deficiency of Vitamin C for several months reduces total body stores from 1500mg to less than 300mg. […] Unlike nearly all other animals, humans are unable to synthesise Vitamin C which must be obtained from the diet. […] Vitamin C is required for maintaining the triple helix structure of collagen, an essential component of connective tissue including support of blood vessels. […] Vitamin C is required for anti-oxidant effect reducing free radicals, with effects on lipid metabolism, atherosclerosis and cardiovascular disease. […] Vitamin C is required for iron absorption from the proximal small intestine.
  • #5 Scurvy – Causes | Symptoms | Diagnosis | Treatment
    https://www.icliniq.com/articles/diseases-and-disorders-common-medical-conditions/scurvy
    Scurvy refers to a condition that occurs when you lack vitamin C in your diet. […] Scurvy is referred to as a severe vitamin C deficiency. This can affect the immune system, absorption of iron, metabolism of cholesterol, and other bodily functions. […] Vitamin C deficiency results from a poor diet that lacks fresh fruits and vegetables. […] The major risk factors or people who are prone to develop vitamin C deficiency include: People above the age of 65, People who consume excessive amounts of alcohol, Use of any illegal drugs, Restrictive diets due to allergies to certain kinds of foods, Reduced access to nutritious food due to low income, Residing in areas where there is poor access to fresh fruits and vegetables, People with eating disorders or psychiatric conditions that involve fear of food, Digestive or any metabolic disorders, People having irritable bowel syndrome, Crohns disease, or ulcerative colitis, Individuals having chronic diarrhea, Dehydration, People on chemotherapy or radiation therapy, Kidney failure. […] Human bodies cannot synthesize vitamin C, and so it has to come from external sources.
  • #6 Scurvy | healthdirect
    https://www.healthdirect.gov.au/scurvy
    Scurvy is a disease caused by low levels of vitamin C over a period for 2 to 3 months. […] You can develop scurvy if you dont have enough vitamin C in your diet for at least 2 to 3 months. […] Vitamin C, which is also known as ascorbic acid, is found mainly in fruit and vegetables. […] You are more at risk of getting scurvy if you: eat a diet without many fruit and vegetables. […] You can even develop scurvy if you live with overweight.
  • #7 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #8 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology
    https://emedicine.medscape.com/article/125350-overview
    Scurvy is caused by a prolonged dietary deficiency of vitamin C. […] The body’s pool of vitamin C can be depleted in 1-3 months. […] Risk factors for vitamin C deficiency include the following: Babies who are fed only cow’s milk or plant-based beverages (almond milk) during the first year of life. […] Other factors that may lead to vitamin C deficiency include ignorance (eg, boiling of fruit juices), restrictive diets imposed by food allergies, and neurodevelopmental disabilities associated with compromised oral intake of foods. […] Studies have shown that iron is important in the absorption of vitamin C, and iron deficiency may lower the expression of the sodium-dependent vitamin C transporter in intestinal cells, leading to vitamin C deficiency. […] In a study of cancer patients with adequate daily intake but low serum vitamin C levels, authors proposed increased use of vitamin C possibly to scavenge lipid peroxides or vitamin C sequestration by tumor cells.
  • #9 Vitamin C Deficiency – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK493187/
    Scurvy is a clinical syndrome resulting from vitamin C deficiency. […] The primary cause of vitamin C deficiency is due to inadequate nutritional intake. […] Vitamin C is naturally present in various fruits and vegetables, such as citrus fruits, potatoes, spinach, broccoli, red peppers, strawberries, and tomatoes. […] Symptoms of scurvy appear within 4 to 12 weeks of insufficient vitamin C intake. […] Several factors can contribute to an increased risk of vitamin C deficiency, some of which are listed below. […] In summary, a range of factors can significantly heighten the risk of vitamin C deficiency. […] Vitamin C deficiency affects millions of individuals globally. […] Scurvy arises due to inadequate vitamin C intake, which is critical in synthesizing collagen. […] Vitamin C deficiency compromises immune function, rendering individuals more susceptible to infections and causing delays in wound healing. […] The complications associated with vitamin C treatment for scurvy are relatively infrequent, generally mild, and often associated with dosage.
  • #10 Scurvy – Causes, Symptoms, Diagnosis, Treatment & Prevention
    https://www.medindia.net/health/conditions/scurvy.htm
    Scurvy is a nutritional disease caused by a diet that lacks vitamin C [Ascorbic acid]. […] The main cause is an insufficient intake of vitamin C. This can be due to: […] Low income families or famine conditions where the diet may be lacking in fresh fruits and vegetables. […] Excessive consumption of alcohol associated with an improper diet. […] Abnormal eating patterns as in anorexia nervosa, or bulimia (serious eating disorders). […] Elderly or widowers who may be careless about their eating habits. […] People who follow diet fads or peculiar diets to lose weight. […] Smoking. […] Difficulty in ingesting foods or those who follow restrictive diets due to allergies and other health problems. […] Crohns disease a chronic inflammatory bowel disease that affects the lining of the digestive tract. […] Ulcerative colitis a condition that results in inflammation and ulcers of the colon and rectum where the bodys ability to absorb nutrients is impaired. […] Populations that subsist mainly on cereal grains. […] Late weaning of infants. […] Eating only cooked or frozen food.
  • #11 Scurvy: Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/24318-scurvy
    Scurvy is a disease caused by a serious vitamin C deficiency. Not eating enough fruits and vegetables is the main cause of the disease. […] Scurvy is a disease caused by a significant lack of vitamin C in your diet. The medical definition of scurvy is severe vitamin C (ascorbic acid) deficiency. […] Vitamin C deficiency can occur due to a diet low in vitamin C. But a deficiency severe enough to cause scurvy is rare in the U.S. because most people get enough of the nutrient in their diet. […] A severe lack of vitamin C in your diet for at least three months can cause scurvy. Reasons for this deficiency include not eating enough fresh fruits and vegetables. Also, cooking destroys some of the vitamin C found in food. […] Scurvy treatment is essential to avoid further complications. The condition is easily treatable by consuming more vitamin C.
  • #12 The Age of Scurvy | Science History Institute
    https://www.sciencehistory.org/stories/magazine/the-age-of-scurvy/
    Scurvy killed more than two million sailors between the time of Columbuss transatlantic voyage and the rise of steam engines in the mid-19th century. […] According to historian Stephen Bown scurvy was responsible for more deaths at sea than storms, shipwrecks, combat, and all other diseases combined. […] Scurvy was responsible for more deaths at sea than storms, shipwrecks, combat, and all other diseases combined. […] This disease so frequently attending long voyages, and so particularly destructive to us, is surely the most singular and unaccountable of any that afflicts the human body, Walter later wrote. […] In the case of scurvy the issue is collagen, a primary structural protein in our muscle, skin, bones, blood vessels, cartilage, scars, and other connective tissues that makes up some 30% of the protein in the human body.
  • #13 Scurvy? Symptoms, Causes and Treatments
    https://www.webmd.com/skin-problems-and-treatments/what-to-know-scurvy
    Scurvy is a sign of serious malnutrition, specifically a lack of vitamin C. […] Scurvy is a serious vitamin C deficiency. The human body needs vitamin C to make collagen (the tissue that connects your muscles and bones and makes up your skin), heal wounds, support your immune system, and help with many other internal processes. […] Scurvy may form if you: […] A lack of vitamin C causes scurvy, which leads to symptoms such as fatigue, bleeding gums, bruising, and slow wound healing.
  • #14
    https://www.orthobullets.com/basic-science/9034/scurvy
    Scurvy is disease caused by severe Vitamin C deficiency which presents with joint effusions, swelling over long bones, bleeding gums, loosening of teeth, hematuria, and susceptibility to hemorrhage. […] Vitamin C deficiency leads to decrease in chondroitin sulfate and collagen synthesis and repair. […] impaired intracellular hydroxylation of collagen peptides. […] net effect is altered bone formation with the greatest effect occurring in the metaphysis. […] defect in spongiosa of the metaphysis at the growth plate. […] because the demand for type I collagen is greatest during new bone formation. […] 8% of men and 6% of women in the US have vitamin C deficiency. […] elderly, especially men who live alone, chronic malnutrition, overcooking destroys vitamin C, alcoholic, smokers, malabsorptive conditions (Whipple’s disease, inflammatory bowel disease, cancer chemotherapy). […] humans are unable to synthesize L-ascorbic acid because the enzyme L-gluconolactone oxidase is nonfunctional.
  • #15 Scurvy (vitamin C deficiency)
    https://dermnetnz.org/topics/scurvy
    Scurvy develops when sustained dietary deficiency of Vitamin C for several months reduces total body stores from 1500mg to less than 300mg. […] Unlike nearly all other animals, humans are unable to synthesise Vitamin C which must be obtained from the diet. […] Vitamin C is required for maintaining the triple helix structure of collagen, an essential component of connective tissue including support of blood vessels. […] Vitamin C is required for anti-oxidant effect reducing free radicals, with effects on lipid metabolism, atherosclerosis and cardiovascular disease. […] Vitamin C is required for iron absorption from the proximal small intestine.
  • #16
    https://byjus.com/biology/scurvy/
    Scurvy is a disease caused by a severe deficiency of vitamin C, hence it is also called chronic vitamin C deficiency disorder. […] The main cause of Scurvy is an insufficient intake of vitamin C or ascorbic acid in our diet. […] Vitamin C is required for the production of collagen which is an important component in the connective tissue. […] Lack of vitamin C leads to the underproduction of collagen which results in the breakdown of body tissues. […] Vitamin C also helps in iron absorption. A deficiency of vitamin C leads to anaemia. […] There are a few medical conditions and certain lifestyle changes that result in the deficiency of vitamin C. These include- age factors, consumption of alcohol, use of tobacco products, addiction to drugs, living alone, malnutrition, disabilities, patients suffering from kidney disorders, intake of more carbohydrates, etc.
  • #17 Scurvy Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/scurvy
    Scurvy is a disease that occurs when you have a severe lack of vitamin C (ascorbic acid) in your diet. […] Scurvy causes general weakness, anemia, gum disease, poor wound healing, and skin hemorrhages. […] Scurvy is rare in the United States. Older adults who are not getting proper nutrition are most affected by scurvy.
  • #18 FloridaHealthFinder | Scurvy | Health Encyclopedia | FloridaHealthFinder
    https://quality.healthfinder.fl.gov/health-encyclopedia/HIE/1/000355
    Scurvy is a disease that occurs when you have a severe lack of vitamin C (ascorbic acid) in your diet. Scurvy causes general weakness, anemia, gum disease, poor wound healing, and skin hemorrhages. […] Scurvy is rare in the United States. Older adults who are not getting proper nutrition are most affected by scurvy.
  • #19 dentist Lakewood CA – Causes of Scurvy | Lakewood Dental Arts
    https://lakewooddentalarts.com/p/BLOG-83332-2021.6.21-Causes-of-Scurvy-p.asp
    Scurvy is caused by a severe deficiency of Vitamin C. […] Some of these causes are: […] A Diet That Lacks Citrus Fruits and Vegetables […] People who regularly eat unhealthy foods like fast food and meaty meals and do not include fresh fruits and vegetables in their diet develop scurvy because their body becomes deficient in Vitamin C. […] Malnourishment can also cause scurvy. […] Eating disorders like anorexia and bulimia can also result in a deficiency of Vitamin C. […] The severe deficiency of Vitamin C in their bodies makes them susceptible to scurvy. […] Certain kinds of intestinal infections and bowel diseases like inflammatory bowel disease, Crohn’s disease, irritable bowel syndrome, and ulcerative colitis can affect the absorption of Vitamin C from foods. […] If these digestive disorders and intestinal infections are left untreated, over time, our body can become deficient in vitamin C, and we can develop scurvy.
  • #20 Scurvy | nidirect
    https://www.nidirect.gov.uk/conditions/scurvy
    Scurvy is caused by not having enough vitamin C in your diet for at least three months. […] Other groups who may be more at risk of scurvy include: people with a severe digestive condition, such as Crohn’s disease or ulcerative colitis. […] Scurvy is easily treated by adding some vitamin C to your diet, such as fresh fruit and vegetables. […] Your GP may refer you to a specialist for treatment, support or advice. This depends on what’s causing your scurvy.
  • #21 Scurvy: Rediscovering a Forgotten Disease
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10296835/
    Scurvy is a nutritional deficiency caused by low vitamin C levels that has been described since ancient times. […] Although there has been a dramatic reduction in the prevalence of scurvy in modern times owing to vitamin C supplementation and intake, sporadic cases still occur. […] In developed countries, it is mainly diagnosed in the elderly and malnourished individuals and is associated with alcoholism, low socio-economic status, and poor dietary habits. […] Scurvy has been an unusual cause of gastrointestinal (GI) bleeding among other GI manifestations. […] Some of the risk factors that predispose these patients to the disease are chronic alcohol use, dietary insufficiency, and obesity. […] A poor intake of vitamin-C-rich foods is a more obvious cause of deficiency when compared to obesity and abdominal surgeries.
  • #22 The British 'Limeys’ Were Right: A Short History of Scurvy | Health.mil
    https://health.mil/News/Articles/2022/01/10/The-British-Limeys-Were-Right-A-Short-History-of-Scurvy
    Scurvy, a disease caused by lack of vitamin C, sickened sailors who had no access to fresh food supplies, and killed more than 2 million sailors between the 16th and 18th centuries alone. […] Scurvy is a dietary deficiency caused by a lack of vitamin C. The body does not naturally make vitamin C, so it has to come from foods rich in the vitamin such as citrus or from dietary supplements. […] The U.S. Navy continued to struggle with scurvy into the 19th century even though the Royal Navy cracked the mystery of the disease in the 18th century thanks to surgeon James Lind. […] Today, scurvy still occurs in developed countries despite the widespread availability of multiple enriched and fortified foods. […] According to the National Institutes of Health, those most at risk for scurvy are: living alone, institutionalized with diets devoid of fresh fruits and vegetables, missing teeth or toothless, showing poor self-care, lacking social support, displaying destructive behaviors such as alcoholism, drug abuse, or smoking, and being mentally or chronically ill.
  • #23 What Is Scurvy? Symptoms, Causes, Diagnosis, Treatment, and Prevention
    https://www.everydayhealth.com/scurvy/
    Scurvy is a disease thats caused by a deficiency in vitamin C (aka ascorbic acid), which is rare in the developed world. […] Scurvy is the direct result of vitamin C deficiency. Signs of scurvy can manifest with a vitamin C intake below 10 mg per day, says Tamar Samuels, RD, the cofounder of Culina Health in New York City. […] Scurvy affects more men than women, and because vitamin C is found in whole fruits and vegetables, a deficiency is associated with poor nutrition. […] Vitamin C deficiency is particularly prevalent among smokers, with vitamin C levels among smokers 33 percent lower than those of nonsmokers, research shows. […] Finally, there are some health conditions that put people at a higher risk of developing scurvy, including type 1 diabetes, eating disorders, gastrointestinal issues, iron overload, restrictive diets, and allergies.
  • #24 Scurvy: Causes, Symptoms, Treatments, and Prevention Tips for a Healthier Life
    https://dentistpeshawar.pk/oral-surgery-tongue-palate-cheeks/scurvy-causes-symptoms-treatments-and-prevention-tips-for-a-healthier-life/
    Scurvy, a disease caused by a severe vitamin C deficiency, has affected humans for centuries. […] A deficiency of vitamin C in the diet remains the primary cause of scurvy, but several other factors contribute to this condition: […] People who do not consume enough fruits and vegetables, particularly those in isolated or impoverished areas, are at risk of developing scurvy. […] Certain medical conditions, such as Crohns disease, ulcerative colitis, and gastrointestinal disorders, hinder vitamin C absorption. […] People on restrictive diets, like extreme low-carb or ketogenic diets, may lack sufficient vitamin C if they exclude most fruits and certain vegetables. […] Scurvy still exists because of lifestyle factors, socioeconomic challenges, and certain medical conditions. […] Individuals relying on processed foods or restrictive diets, like extreme low-carb or fad diets, may inadvertently exclude essential nutrients, including vitamin C. […] Certain groups, such as the elderly, individuals with eating disorders, or people with gastrointestinal conditions, are more susceptible to vitamin C deficiency.
  • #25 What Is Scurvy? Symptoms, Causes, Diagnosis, Treatment, and Prevention
    https://www.everydayhealth.com/scurvy/
    Scurvy is a disease thats caused by a deficiency in vitamin C (aka ascorbic acid), which is rare in the developed world. […] Scurvy is the direct result of vitamin C deficiency. Signs of scurvy can manifest with a vitamin C intake below 10 mg per day, says Tamar Samuels, RD, the cofounder of Culina Health in New York City. […] Scurvy affects more men than women, and because vitamin C is found in whole fruits and vegetables, a deficiency is associated with poor nutrition. […] Vitamin C deficiency is particularly prevalent among smokers, with vitamin C levels among smokers 33 percent lower than those of nonsmokers, research shows. […] Finally, there are some health conditions that put people at a higher risk of developing scurvy, including type 1 diabetes, eating disorders, gastrointestinal issues, iron overload, restrictive diets, and allergies.
  • #26 Explainer: what is scurvy and is it making a comeback?
    https://theconversation.com/explainer-what-is-scurvy-and-is-it-making-a-comeback-69709
    Scurvy is caused by severe and chronic deficiency of vitamin C (ascorbic acid), and is in modern times extremely rare. […] A lack of vitamin C results in a defective formation of collagen and connective tissues, which can result in easy bruising, bleeding gums, blood spots in the skin, joint pain and delayed wound healing. […] The recently reported cases of scurvy reflect poor-quality diets that dont include sufficient fruit and vegetables. […] Some people are more at risk of scurvy than others. Those at high risk are usually elderly people who may have difficulty chewing vitamin C-rich foods, and those with a diet devoid of fresh fruits and vegetables due to low incomes, ignorance or excessively restrictive diets, for example as a result of allergies. […] Smokers are also at an increased risk of scurvy because smoking decreases concentrations of Vitamin C in the blood by up to 40%. […] The re-emergence of scurvy is a poor reflection on the nations diet.
  • #27 Scurvy – Causes | Symptoms | Diagnosis | Treatment
    https://www.icliniq.com/articles/diseases-and-disorders-common-medical-conditions/scurvy
    Scurvy refers to a condition that occurs when you lack vitamin C in your diet. […] Scurvy is referred to as a severe vitamin C deficiency. This can affect the immune system, absorption of iron, metabolism of cholesterol, and other bodily functions. […] Vitamin C deficiency results from a poor diet that lacks fresh fruits and vegetables. […] The major risk factors or people who are prone to develop vitamin C deficiency include: People above the age of 65, People who consume excessive amounts of alcohol, Use of any illegal drugs, Restrictive diets due to allergies to certain kinds of foods, Reduced access to nutritious food due to low income, Residing in areas where there is poor access to fresh fruits and vegetables, People with eating disorders or psychiatric conditions that involve fear of food, Digestive or any metabolic disorders, People having irritable bowel syndrome, Crohns disease, or ulcerative colitis, Individuals having chronic diarrhea, Dehydration, People on chemotherapy or radiation therapy, Kidney failure. […] Human bodies cannot synthesize vitamin C, and so it has to come from external sources.
  • #28 Scurvy Symptoms | Rex MD
    https://rexmd.com/learn/scurvy-symptoms
    Scurvy is a condition that develops due to a severe vitamin C deficiency. […] Scurvy results from a severe vitamin C deficiency. Your body cannot synthesize this essential nutrient naturally, which is why it’s essential to get sufficient vitamin C from food or supplements. […] Several factors elevate the risk of a vitamin C deficiency: Newborns and infants that aren’t breastfed, Adults over the age of 65, Alcohol or drug abuse, Restrictive diets or eating disorders, Living in poverty, being homeless, or a refugee, Digestive conditions like Crohn’s disease, ulcerative colitis, or irritable bowel syndrome, Smoking tobacco, Dialysis, chemotherapy, or radiation therapy, Chronic diarrhea and dehydration, Limited access to fresh fruits and vegetables. […] Scurvy can be fatal if left untreated. […] We have a much better understanding of the causes and treatments for scurvy today.
  • #29 Scurvy: Rediscovering a Forgotten Disease
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10296835/
    The underlying causes of vitamin C deficiency and scurvy in children include psychiatric eating disorders such as avoidant/restrictive food intake disorder and anorexia nervosa, food insecurity, and neglect. […] Scurvy can occur in patients with excess iron secondary to hematological conditions such as thalassemia or sickle cell disease or a prior bone marrow transplantation. […] There have been infrequent cases reporting scurvy presenting as an overt gastrointestinal bleed. […] Scurvy was determined to be the cause after additional testing of vitamin C levels, and hemorrhage was controlled after administration of a high dose of vitamin C. […] The treatment for scurvy is vitamin C supplementation and the reversal of the conditions that led to the deficiency. […] The difficulty in treating hemorrhage caused by scurvy is not in treating the bleeding itself but rather in accurately diagnosing the condition. […] If scurvy is suspected, it can be effectively treated with high doses of Vitamin C.
  • #30 Scurvy: Rediscovering a Forgotten Disease
    https://www.mdpi.com/2079-9721/11/2/78
    The underlying causes of vitamin C deficiency and scurvy in children include psychiatric eating disorders such as avoidant/restrictive food intake disorder and anorexia nervosa, food insecurity, and neglect. […] Another risk group in which scurvy has been reported is children with autism spectrum disorder who have a diet lacking fruits and vegetables. […] The diagnosis of scurvy can be challenging as its symptoms may mimic those of other conditions. […] The treatment for scurvy is vitamin C supplementation and the reversal of the conditions that led to the deficiency. […] Scurvy can affect various organ systems due to its involvement in several biochemical reactions that affect tissue structure. […] In cases in which the cause of gastrointestinal bleeding is an uncontrolled mucosal ooze, a high index of suspicion is necessary.
  • #31 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #32 Scurvy: Symptoms, Causes, Treatment & Diagnosis | Medcare
    https://www.medcare.ae/en/health-library/scurvy-symptoms-causes-treatment-prevention.html
    A severe vitamin C deficiency is the root cause of the disease scurvy. The key factor causing the condition is a lack of fruit and vegetable consumption. […] Scurvy can be brought on by a severe shortage of vitamin C in your diet for at least three months. Consuming insufficient amounts of fresh fruits and vegetables is one cause of this deficit. […] Your body needs more vitamin C when certain situations are present. If you have any of the following conditions, you need more vitamin C and run the danger of deficiency if you don’t obtain enough: Pregnancy, Breastfeeding, Conditions that raise fever levels, Excessive thyroid activity, Persistent diarrhea, Recent surgical procedure, Burns, Use of tobacco.
  • #33 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #34 Scurvy: Symptoms, Causes, Treatment & Diagnosis | Medcare
    https://www.medcare.ae/en/health-library/scurvy-symptoms-causes-treatment-prevention.html
    A severe vitamin C deficiency is the root cause of the disease scurvy. The key factor causing the condition is a lack of fruit and vegetable consumption. […] Scurvy can be brought on by a severe shortage of vitamin C in your diet for at least three months. Consuming insufficient amounts of fresh fruits and vegetables is one cause of this deficit. […] Your body needs more vitamin C when certain situations are present. If you have any of the following conditions, you need more vitamin C and run the danger of deficiency if you don’t obtain enough: Pregnancy, Breastfeeding, Conditions that raise fever levels, Excessive thyroid activity, Persistent diarrhea, Recent surgical procedure, Burns, Use of tobacco.
  • #35 Poorer children hit hardest as scurvy makes a comeback in France
    https://www.rfi.fr/en/france/20250102-poorer-children-hit-hardest-as-scurvy-makes-a-comeback-in-france
    Scurvy, a disease caused by severe vitamin C deficiency, is making a comeback in France. […] Scurvy is caused by a lack of vitamin C, found in fruit such as oranges and some leafy green vegetables. […] Scurvy is caused by a severe deficiency in vitamin C – most commonly found in citrus fruits and leafy green vegetables. […] While improved nutrition has made scurvy virtually extinct in high-income countries, new research has shown a resurgence in France, particularly among young children from low-income families. […] The study noted that food inflation in France had reached 15 percent in January 2023, more than double the overall inflation rate, and found that the „significant increase in scurvy and severe malnutrition among children [is] linked to the escalation of food prices”. […] „Poorer families cannot, or can no longer, afford to buy products that provide enough vitamin C, such as vegetables or fruit,” Meinzer said.
  • #36 Nutritional disorders: what causes scurvy? – InternationalDrugMart
    https://www.internationaldrugmart.com/blog/causes-scurvy/
    One of the oldest known nutritional disorders, Vitamin C deficiency presently affects close to 17 percent of low-income population groups. The lack of dietary vitamin C causes the disease that was initially associated with only pirates of a bygone era. Popularly known as scurvy, the disease is attributed to insufficient intake of ascorbic acid, or a lack of ascorbic acid, typically found in fruits and vegetables especially fruits belonging to the citrus family. […] Low income groups without access to fresh produce or products that are fortified/enriched with vitamin C are at higher risk of contracting scurvy. […] As we learn more about what causes scurvy it is essential to identify individuals or sections of society that are higher risk of contracting the condition. […] Patients with certain conditions that impact the ability of the body to absorb vitamin C. For instance patients on routine dialysis are known to have lesser ability to intake vitamin C. Similarly, patients with severe dyspepsia and Crohns disease are also at risk of developing scurvy.
  • #37 Scurvy: Rediscovering a Forgotten Disease
    https://www.mdpi.com/2079-9721/11/2/78
    The underlying causes of vitamin C deficiency and scurvy in children include psychiatric eating disorders such as avoidant/restrictive food intake disorder and anorexia nervosa, food insecurity, and neglect. […] Another risk group in which scurvy has been reported is children with autism spectrum disorder who have a diet lacking fruits and vegetables. […] The diagnosis of scurvy can be challenging as its symptoms may mimic those of other conditions. […] The treatment for scurvy is vitamin C supplementation and the reversal of the conditions that led to the deficiency. […] Scurvy can affect various organ systems due to its involvement in several biochemical reactions that affect tissue structure. […] In cases in which the cause of gastrointestinal bleeding is an uncontrolled mucosal ooze, a high index of suspicion is necessary.
  • #38
    https://consensus.app/questions/what-causes-scurvy/
    Scurvy is primarily caused by a deficiency of vitamin C, also known as ascorbic acid. This essential nutrient plays a crucial role in the synthesis of collagen, a protein necessary for the maintenance of healthy connective tissues, skin, blood vessels, and bones. Without adequate vitamin C, the body cannot properly form collagen, leading to the symptoms associated with scurvy. […] Individuals who consume a restricted or peculiar diet for extended periods are at high risk of developing scurvy. […] Children with abnormal dietary habits, mental or physical disabilities, or those with avoidant-restrictive food intake disorder (ARFID) are particularly susceptible to scurvy. […] Scurvy is more commonly diagnosed in individuals with low socioeconomic status, the elderly, and those suffering from alcoholism. These groups often have poor dietary habits that lack sufficient vitamin C intake.
  • #39 Scurvy: Rediscovering a Forgotten Disease
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10296835/
    The underlying causes of vitamin C deficiency and scurvy in children include psychiatric eating disorders such as avoidant/restrictive food intake disorder and anorexia nervosa, food insecurity, and neglect. […] Scurvy can occur in patients with excess iron secondary to hematological conditions such as thalassemia or sickle cell disease or a prior bone marrow transplantation. […] There have been infrequent cases reporting scurvy presenting as an overt gastrointestinal bleed. […] Scurvy was determined to be the cause after additional testing of vitamin C levels, and hemorrhage was controlled after administration of a high dose of vitamin C. […] The treatment for scurvy is vitamin C supplementation and the reversal of the conditions that led to the deficiency. […] The difficulty in treating hemorrhage caused by scurvy is not in treating the bleeding itself but rather in accurately diagnosing the condition. […] If scurvy is suspected, it can be effectively treated with high doses of Vitamin C.
  • #40 On the Genetic Etiology of Scurvy | Acta geneticae medicae et gemellologiae: twin research | Cambridge Core
    https://www.cambridge.org/core/journals/amg-acta-geneticae-medicae-et-gemellologiae-twin-research/article/on-the-genetic-etiology-of-scurvy/124A339425405DB5112FFF3101934CE9
    Scurvy, now regarded as a nutritional disorder due to the lack of the trace food constituent, vitamin C, is shown to be the end result of a typical genetic disease. […] Its primary cause is the hereditary lack of or defect in the gene controlling the synthesis of the enzyme, L-gulonolactone oxidase. […] The gene defect occurred during the course of evolution by a conditional lethal mutation. […] The replacement of the present vitamin C theory regarding the etiology of scurvy by this genetic concept gives important new viewpoints to the quantitative aspects of ascorbic acid in human physiology and also provides new rationales for the use of high levels of ascorbic acid in normal physiology and in the therapy of clinical entities other than scurvy.
  • #41 The Age of Scurvy | Science History Institute
    https://www.sciencehistory.org/stories/magazine/the-age-of-scurvy/
    Without collagen our bodies would come apart from withinhence the hemorrhaging, broken bones, and loose teeth of scurvy. […] Early explorers didnt know about collagen or enzymes. […] Many popular hypotheses about scurvys cause were still related to the ancient theory of the humours, including alkalinity, acidity, too much black bile, and blocked perspiration. […] Humansalong with guinea pigs, fruit bats, and several other simiansare the only mammals that cant make their own vitamin C. […] Scurvy was not confined to the sea. […] And even though we now understand both cause and cure, scurvy persists. […] Scurvy can never be eradicated; adequate nutrition is its only prevention and only cure.
  • #42 Scurvy (vitamin C deficiency)
    https://dermnetnz.org/topics/scurvy
    Scurvy develops when sustained dietary deficiency of Vitamin C for several months reduces total body stores from 1500mg to less than 300mg. […] Unlike nearly all other animals, humans are unable to synthesise Vitamin C which must be obtained from the diet. […] Vitamin C is required for maintaining the triple helix structure of collagen, an essential component of connective tissue including support of blood vessels. […] Vitamin C is required for anti-oxidant effect reducing free radicals, with effects on lipid metabolism, atherosclerosis and cardiovascular disease. […] Vitamin C is required for iron absorption from the proximal small intestine.
  • #43 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #44 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #45 Vitamin C Deficiency – Nutritional Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-c-deficiency
    Severe vitamin C deficiency results in scurvy, a disorder characterized by hemorrhagic manifestations and abnormal osteoid and dentin formation. […] Primary vitamin C deficiency is usually due to inadequate diet. […] The need for dietary vitamin C is increased by febrile illnesses, inflammatory disorders (particularly diarrheal disorders), achlorhydria, smoking, hyperthyroidism, iron deficiency, cold or heat stress, surgery, burns, and protein deficiency. […] When vitamin C is deficient, formation of intercellular cement substances in connective tissues, bones, and dentin is defective, resulting in weakened capillaries with subsequent hemorrhage and defects in bone and related structures. […] After weeks or months, the deficiency causes nonspecific symptoms (eg, weakness, lassitude, irritability, arthralgias, myalgias); later, connective tissue is affected, causing follicular hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages.
  • #46 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #47 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #48 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    In countries with low rates of food insecurity, vitamin C deficiency can occur from a diet low in vitamin C, but severe deficiency (causing scurvy) is uncommon. […] Not eating enough fresh fruits and vegetables can cause the deficiency. […] Severe vitamin C deficiency causes scurvy. […] Scurvy is rare in the United States but may occur in people with alcohol use disorder and older people who are malnourished. […] For example, vitamin C deficiency may result from a diet deficient in fresh fruits and vegetables. […] The following conditions can significantly increase the body’s requirements for vitamin C and the risk of vitamin C deficiency: Pregnancy, Breastfeeding, Disorders that cause a high fever or inflammation, An overactive thyroid gland (hyperthyroidism), Diarrhea that lasts a long time, Surgery, Burns, Smoking, which increases the vitamin C requirement by 30%.
  • #49 Scurvy: Symptoms, Causes, Treatment & Diagnosis | Medcare
    https://www.medcare.ae/en/health-library/scurvy-symptoms-causes-treatment-prevention.html
    A severe vitamin C deficiency is the root cause of the disease scurvy. The key factor causing the condition is a lack of fruit and vegetable consumption. […] Scurvy can be brought on by a severe shortage of vitamin C in your diet for at least three months. Consuming insufficient amounts of fresh fruits and vegetables is one cause of this deficit. […] Your body needs more vitamin C when certain situations are present. If you have any of the following conditions, you need more vitamin C and run the danger of deficiency if you don’t obtain enough: Pregnancy, Breastfeeding, Conditions that raise fever levels, Excessive thyroid activity, Persistent diarrhea, Recent surgical procedure, Burns, Use of tobacco.
  • #50 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology
    https://emedicine.medscape.com/article/125350-overview
    Scurvy is caused by a prolonged dietary deficiency of vitamin C. […] The body’s pool of vitamin C can be depleted in 1-3 months. […] Risk factors for vitamin C deficiency include the following: Babies who are fed only cow’s milk or plant-based beverages (almond milk) during the first year of life. […] Other factors that may lead to vitamin C deficiency include ignorance (eg, boiling of fruit juices), restrictive diets imposed by food allergies, and neurodevelopmental disabilities associated with compromised oral intake of foods. […] Studies have shown that iron is important in the absorption of vitamin C, and iron deficiency may lower the expression of the sodium-dependent vitamin C transporter in intestinal cells, leading to vitamin C deficiency. […] In a study of cancer patients with adequate daily intake but low serum vitamin C levels, authors proposed increased use of vitamin C possibly to scavenge lipid peroxides or vitamin C sequestration by tumor cells.
  • #51 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology
    https://emedicine.medscape.com/article/125350-overview
    Scurvy is caused by a prolonged dietary deficiency of vitamin C. […] The body’s pool of vitamin C can be depleted in 1-3 months. […] Risk factors for vitamin C deficiency include the following: Babies who are fed only cow’s milk or plant-based beverages (almond milk) during the first year of life. […] Other factors that may lead to vitamin C deficiency include ignorance (eg, boiling of fruit juices), restrictive diets imposed by food allergies, and neurodevelopmental disabilities associated with compromised oral intake of foods. […] Studies have shown that iron is important in the absorption of vitamin C, and iron deficiency may lower the expression of the sodium-dependent vitamin C transporter in intestinal cells, leading to vitamin C deficiency. […] In a study of cancer patients with adequate daily intake but low serum vitamin C levels, authors proposed increased use of vitamin C possibly to scavenge lipid peroxides or vitamin C sequestration by tumor cells.
  • #52 Scurvy – Causes | Symptoms | Diagnosis | Treatment
    https://www.icliniq.com/articles/diseases-and-disorders-common-medical-conditions/scurvy
    Scurvy refers to a condition that occurs when you lack vitamin C in your diet. […] Scurvy is referred to as a severe vitamin C deficiency. This can affect the immune system, absorption of iron, metabolism of cholesterol, and other bodily functions. […] Vitamin C deficiency results from a poor diet that lacks fresh fruits and vegetables. […] The major risk factors or people who are prone to develop vitamin C deficiency include: People above the age of 65, People who consume excessive amounts of alcohol, Use of any illegal drugs, Restrictive diets due to allergies to certain kinds of foods, Reduced access to nutritious food due to low income, Residing in areas where there is poor access to fresh fruits and vegetables, People with eating disorders or psychiatric conditions that involve fear of food, Digestive or any metabolic disorders, People having irritable bowel syndrome, Crohns disease, or ulcerative colitis, Individuals having chronic diarrhea, Dehydration, People on chemotherapy or radiation therapy, Kidney failure. […] Human bodies cannot synthesize vitamin C, and so it has to come from external sources.
  • #53 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal
    https://amj.amegroups.org/article/view/9986/html
    Scurvy is a multi-organ syndrome caused by a deficiency of vitamin C. […] Scurvy can present with a variety of signs and symptoms including fatigue, neuropsychiatric disturbances, arthralgia, gingivitis, and hemorrhagic skin lesions. […] Vitamin C deficiency is primarily caused by the inadequate consumption of vitamin-rich fruits and vegetables. […] In the modern era, however, additional causes include inadequate gastrointestinal absorption and increased serum clearance from oxidative stress or exogenous filtration during dialysis. […] Risk factors for vitamin C deficiency in the United States (US) reflect these causes and include socioeconomic barriers to fresh fruit and vegetable access, significant alcohol consumption, inflammatory gastrointestinal disease, chronic glucocorticoid or proton pump inhibitor use, smoking, malignancy, and dialysis.
  • #54 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal
    https://amj.amegroups.org/article/view/9986/html
    Scurvy is a multi-organ syndrome caused by a deficiency of vitamin C. […] Scurvy can present with a variety of signs and symptoms including fatigue, neuropsychiatric disturbances, arthralgia, gingivitis, and hemorrhagic skin lesions. […] Vitamin C deficiency is primarily caused by the inadequate consumption of vitamin-rich fruits and vegetables. […] In the modern era, however, additional causes include inadequate gastrointestinal absorption and increased serum clearance from oxidative stress or exogenous filtration during dialysis. […] Risk factors for vitamin C deficiency in the United States (US) reflect these causes and include socioeconomic barriers to fresh fruit and vegetable access, significant alcohol consumption, inflammatory gastrointestinal disease, chronic glucocorticoid or proton pump inhibitor use, smoking, malignancy, and dialysis.
  • #55 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal
    https://amj.amegroups.org/article/view/9986/html
    Scurvy is a multi-organ syndrome caused by a deficiency of vitamin C. […] Scurvy can present with a variety of signs and symptoms including fatigue, neuropsychiatric disturbances, arthralgia, gingivitis, and hemorrhagic skin lesions. […] Vitamin C deficiency is primarily caused by the inadequate consumption of vitamin-rich fruits and vegetables. […] In the modern era, however, additional causes include inadequate gastrointestinal absorption and increased serum clearance from oxidative stress or exogenous filtration during dialysis. […] Risk factors for vitamin C deficiency in the United States (US) reflect these causes and include socioeconomic barriers to fresh fruit and vegetable access, significant alcohol consumption, inflammatory gastrointestinal disease, chronic glucocorticoid or proton pump inhibitor use, smoking, malignancy, and dialysis.
  • #56 Poorer children hit hardest as scurvy makes a comeback in France
    https://www.rfi.fr/en/france/20250102-poorer-children-hit-hardest-as-scurvy-makes-a-comeback-in-france
    Scurvy, a disease caused by severe vitamin C deficiency, is making a comeback in France. […] Scurvy is caused by a lack of vitamin C, found in fruit such as oranges and some leafy green vegetables. […] Scurvy is caused by a severe deficiency in vitamin C – most commonly found in citrus fruits and leafy green vegetables. […] While improved nutrition has made scurvy virtually extinct in high-income countries, new research has shown a resurgence in France, particularly among young children from low-income families. […] The study noted that food inflation in France had reached 15 percent in January 2023, more than double the overall inflation rate, and found that the „significant increase in scurvy and severe malnutrition among children [is] linked to the escalation of food prices”. […] „Poorer families cannot, or can no longer, afford to buy products that provide enough vitamin C, such as vegetables or fruit,” Meinzer said.
  • #57 Scurvy: Symptoms, Risk Factors, Treatment, Recovery, and More
    https://www.healthline.com/health/scurvy
    Scurvy is better known as severe vitamin C deficiency. […] Your body cannot make vitamin C. That means you have to consume all of the vitamin C your body needs through food or drinks, or by taking a supplement. […] Most people with scurvy lack access to fresh fruits and vegetables or do not have a healthy diet. Scurvy impacts many people in the developing world. […] Public health surveys published in 2008 have shown that scurvy may be far more prevalent in developed nations than once thought, especially in at-risk segments of the population. Medical conditions and lifestyle habits also increase the risk of the condition. […] Scurvy is caused by a chronic vitamin C deficiency. Most cases: […] If left untreated, chronic scurvy can cause serious health complications.
  • #58 Poorer children hit hardest as scurvy makes a comeback in France
    https://www.rfi.fr/en/france/20250102-poorer-children-hit-hardest-as-scurvy-makes-a-comeback-in-france
    Scurvy, a disease caused by severe vitamin C deficiency, is making a comeback in France. […] Scurvy is caused by a lack of vitamin C, found in fruit such as oranges and some leafy green vegetables. […] Scurvy is caused by a severe deficiency in vitamin C – most commonly found in citrus fruits and leafy green vegetables. […] While improved nutrition has made scurvy virtually extinct in high-income countries, new research has shown a resurgence in France, particularly among young children from low-income families. […] The study noted that food inflation in France had reached 15 percent in January 2023, more than double the overall inflation rate, and found that the „significant increase in scurvy and severe malnutrition among children [is] linked to the escalation of food prices”. […] „Poorer families cannot, or can no longer, afford to buy products that provide enough vitamin C, such as vegetables or fruit,” Meinzer said.
  • #59
    https://www.who.int/publications/i/item/WHO-NHD-99.11
    Severe vitamin C deficiency causes scurvy, a disease that is mainly associated with long sea voyages and naval expeditions until the 19th century. […] Scurvy manifests itself 2-3 months after consuming a diet lacking vitamin c; it is characterized by multiple haemorrhages and, left untreated, is fatal. […] In the past decade, several refugee populations that were wholly dependent on food aid have developed scurvy.
  • #60 Scurvy – Wikipedia
    https://en.wikipedia.org/wiki/Scurvy
    Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). […] Causes include a lack of vitamin C. […] Scurvy, including subclinical scurvy, is caused by a deficiency of dietary vitamin C since humans are unable to synthesize vitamin C. […] Although rare, there are also documented cases of scurvy due to poor dietary choices by people living in industrialized nations. […] Scurvy is one of the accompanying diseases of malnutrition and thus is still widespread in areas of the world dependent on external food aid.
  • #61 Hypovitaminosis C (scurvy) | Radiology Reference Article | Radiopaedia.org
    https://radiopaedia.org/articles/hypovitaminosis-c-scurvy-1?lang=us
    Scurvy is a condition caused by a dietary lack of vitamin C (ascorbic acid), hence is also called hypovitaminosis C, and is characterized by an increased bleeding tendency and impaired collagen synthesis resulting in osteoporosis and impaired wound healing. […] Lack of dietary vitamin C (ascorbic acid) may be related to inadequate food intake, the destruction of vitamin C in food caused by cooking and canning, or the absence of fresh fruit in the diet. […] Vitamin C is essential for collagen synthesis, acting as a coenzyme to producing cross-linking of collagen fibers. Defective collagen cross-linking compromises skin, joint, bone, and vascular integrity.
  • #62 Scurvy may occur even in children with no underlying risk factors: a case report | Journal of Medical Case Reports | Full Text
    https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-020-2341-z
    Scurvy is caused by vitamin C deficiency. Cutaneous bleeding, mucosal bleeding, and anemia represent typical manifestations of the disease. These symptoms are directly connected to ascorbic acid involvement in collagen biosynthesis. […] Scurvy, also known as vitamin C deficiency, is an ancient disease that has existed for more than 3 millennia. In modern developed countries, this condition has become very rare and may only occasionally be encountered; it is mainly associated with underlying comorbidities and risk factors. […] The present case report demonstrates that scurvy may sporadically occur in pediatric patients, even in individuals with no predisposing medical conditions and/or potential risk factors. […] An unusual aspect of the present case was the absence of any potential risk factors, which demonstrates that scurvy may still be occasionally encountered in the pediatric population, even in individuals with no predisposing disorders, living in families without unusual eating habits.
  • #63 Vitamin C Deficiency – Disorders of Nutrition – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-c-deficiency
    Scurvy is treated with high doses of daily vitamin C (ascorbic acid) supplements, followed by a nutritious diet that supplies 1 to 2 times the daily recommended amount of vitamin C. […] Vitamin C deficiency can be prevented by consuming the recommended amounts of fresh fruits and vegetables or by taking the recommended amount of vitamin C in daily supplements.
  • #64 Scurvy: Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/24318-scurvy
    Scurvy is a disease caused by a serious vitamin C deficiency. Not eating enough fruits and vegetables is the main cause of the disease. […] Scurvy is a disease caused by a significant lack of vitamin C in your diet. The medical definition of scurvy is severe vitamin C (ascorbic acid) deficiency. […] Vitamin C deficiency can occur due to a diet low in vitamin C. But a deficiency severe enough to cause scurvy is rare in the U.S. because most people get enough of the nutrient in their diet. […] A severe lack of vitamin C in your diet for at least three months can cause scurvy. Reasons for this deficiency include not eating enough fresh fruits and vegetables. Also, cooking destroys some of the vitamin C found in food. […] Scurvy treatment is essential to avoid further complications. The condition is easily treatable by consuming more vitamin C.
  • #65 Poorer children hit hardest as scurvy makes a comeback in France
    https://www.rfi.fr/en/france/20250102-poorer-children-hit-hardest-as-scurvy-makes-a-comeback-in-france
    Combatting the resurgence of scurvy means ensuring that children have a balanced diet „starting with fresh food and cooking it gently,” Meinzer noted. […] The report said its findings underscored a „critical need to intensify food and social assistance programmes” to reduce malnutrition and food insecurity.