Materiały źródłowe

• #1 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Vitamin C deficiency, commonly called scurvy, is a well-documented nutritional disorder with historical significance that continues to impact global health today. […] Scurvy is a rare and reversible condition that requires early diagnosis and treatment. This activity reviews the historical background, clinical manifestations, diagnosis, treatment, and preventive measures concerning vitamin C deficiency. This activity also highlights the critical role of the interprofessional team in providing care for affected patients and raising awareness about nutritional deficiencies. […] Scurvy is a clinical syndrome resulting from vitamin C deficiency. Vitamin C is essential for the growth and repair of skin, cartilage, bone, and teeth. […] Vitamin C deficiency exhibits distinctive histopathological features.

• #2 9.33 Vitamin C Deficiency (Scurvy) | Nutrition

  https://courses.lumenlearning.com/atd-herkimer-nutrition/chapter/9-33-vitamin-c-deficiency-scurvy/

  Why should you care about the functions of vitamin C? Because they explain the symptoms of vitamin C deficiency. While it is rare in the United States, vitamin C deficiency, known as scurvy, displays symptoms that are a result of weak collagen, that in turn, weakens connective tissue throughout the body. Symptoms of scurvy include bleeding gums, pinpoint hemorrhages, and corkscrew hairs as shown in the figure and link below. […] Additional symptoms include impaired wound and fracture healing, easy bruising, and loose or decaying teeth. Scurvy can be fatal if not treated. […] Lind was a surgeon on a British navy ship. Frequently during voyages the sailors would develop scurvy for reasons that weren’t understood at the time. It was known that citrus fruits could cure or prevent scurvy, but it was believed this was due to their acidity. Lind performed clinical trials comparing citrus juice to dilute sulfuric acid and vinegar and found that only citrus juice caused the sailors to recover, as depicted in the link below. As a result of the discovery, the British sailors became known as Limeys because they would drink lime juice to prevent the development of the disease.

• #3 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal

  https://amj.amegroups.org/article/view/9986/html

  Scurvy is a multi-organ syndrome caused by a deficiency of vitamin C. […] Scurvy can present with a variety of signs and symptoms including fatigue, neuropsychiatric disturbances, arthralgia, gingivitis, and hemorrhagic skin lesions. […] This report aims to highlight the diversity of risk factors for vitamin C deficiency and the challenges of treating patients facing barriers to adequate nutrition and healthcare access. […] A diagnosis of scurvy was confirmed with undetectable serum vitamin C (0.1 mg/dL; reference range, 0.42.0 mg/dL), and a subsequent dietary history revealed recent food insecurity. […] Treatment includes high-dose vitamin C supplementation, but careful patient education and interdisciplinary support may be necessary to prevent recurrence in high-risk populations.

• #4 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  My patient came to me in agony. His hands and feet hurt, and had for many years, and his gums were swollen. He asked me for medication to dull his pain. […] I often see patients struggling with scurvy, a disease long forgotten by the medical system. […] And scurvy still exists. […] Scurvy is a disease resulting from inadequate vitamin C intake for at least three months. […] Scurvy now primarily affects populations with limited access to nutritious food, such as people experiencing food insecurity, smokers, those with certain eating disorders, and individuals with malabsorption disorders or severe dietary restrictions. […] Even though my patient had all the signs and symptoms of scurvy, no one in the health care system recognized that he had been struggling with malnutrition for more than 30 years.

• #5 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Initially, nonspecific symptoms of scurvy emerge after 4 to 12 weeks of insufficient intake of vitamin C. Patients might present with fatigue, malaise, lethargy, and anorexia. […] Treating scurvy involves consuming sufficient fruits and vegetables to prevent recurrences and addressing the underlying causes of malnutrition that lead to vitamin C deficiency. […] A multidisciplinary approach involving physicians, advanced care practitioners, nurses, dieticians, dentists, dental hygienists, and pharmacists is vital for providing patient-centered care, enhancing outcomes, and maintaining patient safety. Each healthcare team member should possess specialized skills in assessing, diagnosing, and managing vitamin C deficiency. […] Effectively addressing vitamin C deficiency demands the coordinated efforts of an interprofessional team.

• #6 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Initially, nonspecific symptoms of scurvy emerge after 4 to 12 weeks of insufficient intake of vitamin C. Patients might present with fatigue, malaise, lethargy, and anorexia. […] Treating scurvy involves consuming sufficient fruits and vegetables to prevent recurrences and addressing the underlying causes of malnutrition that lead to vitamin C deficiency. […] A multidisciplinary approach involving physicians, advanced care practitioners, nurses, dieticians, dentists, dental hygienists, and pharmacists is vital for providing patient-centered care, enhancing outcomes, and maintaining patient safety. Each healthcare team member should possess specialized skills in assessing, diagnosing, and managing vitamin C deficiency. […] Effectively addressing vitamin C deficiency demands the coordinated efforts of an interprofessional team.

• #7 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Scurvy (scorbutus) is the clinical disease caused by Vitamin C (ascorbic acid) deficiency with characteristic mucocutaneous and musculoskeletal manifestations. […] Scurvy can affect all age groups, both sexes, and all races. It remains surprisingly common worldwide in both developed and developing countries. […] The initial clinical features of scurvy are non-specific and include: General malaise and lethargy, Poor appetite and failure to thrive, Ill temper, Fever and tachypnoea. […] As the condition progresses, shortness of breath, wasting, anaemia, oedema, mucocutaneous changes, ocular and musculoskeletal symptoms develop. […] The recommended daily intake of Vitamin C in Australia and New Zealand is 45 mg/d. Pregnant and lactating women need 55-85 mg/d. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #8 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Scurvy (scorbutus) is the clinical disease caused by Vitamin C (ascorbic acid) deficiency with characteristic mucocutaneous and musculoskeletal manifestations. […] Scurvy can affect all age groups, both sexes, and all races. It remains surprisingly common worldwide in both developed and developing countries. […] The initial clinical features of scurvy are non-specific and include: General malaise and lethargy, Poor appetite and failure to thrive, Ill temper, Fever and tachypnoea. […] As the condition progresses, shortness of breath, wasting, anaemia, oedema, mucocutaneous changes, ocular and musculoskeletal symptoms develop. […] The recommended daily intake of Vitamin C in Australia and New Zealand is 45 mg/d. Pregnant and lactating women need 55-85 mg/d. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #9 Scurvy: Symptoms, causes, treatment, and prevention

  https://www.medicalnewstoday.com/articles/155758

  Scurvy is a condition that results from a vitamin C deficiency. Scurvy symptoms and signs can include anemia, exhaustion, spontaneous bleeding, limb pain, swelling, and sometimes ulceration of the gums and loss of teeth. […] Scurvy is treatable with oral or intravenous vitamin C supplements. […] Treatment involves administering vitamin C supplements by mouth or by injection. […] A person can prevent scurvy by consuming enough vitamin C, preferably through their regular diet, but sometimes as a supplement. […] The treatment is to consume vitamin C through either diet or supplements.

• #10 Scurvy | Lima Memorial Health System

  https://www.limamemorial.org/health-library/HIE%20Multimedia/1/000355

  Scurvy is a disease that occurs when you have a severe lack of vitamin C (ascorbic acid) in your diet. Scurvy causes general weakness, anemia, gum disease, poor wound healing, and skin hemorrhages. […] Scurvy is rare in the United States. Older adults who are not getting proper nutrition are most affected by scurvy. […] Scurvy is a nutritional disease caused by deficiency of vitamin C. Common symptoms include pinpoint bleeding around hair follicles, along the gums, and under the nails, as seen in this photograph. This disease rarely occurs in the United States. […] Scurvy is a nutritional disease caused by deficiency of vitamin C. Pinpoint bleeding around hair follicles, and corkscrew hairs as seen in this picture, can occur as a result of scurvy. Bleeding along the gums is common. This disease rarely occurs in the United States. […] Corkscrew hairs in hyperkeratotic follicles are pathognomonic of scurvy, or vitamin C deficiency. Petechiae and subungual hemorrhage may also be seen.

• #11

  https://journals.lww.com/onlinejets/fulltext/2024/17020/scurvy__a_rare_disease_or_a_rare_diagnosis_.2.aspx

  Scurvy, the disease state caused by ascorbic acid deficiency, was once an extremely common disease but is now thought to be a rare disease in postmodern societies. […] The detection of 12 cases of scurvy by one physician over a three-decade period highlights the importance of screening for scurvy in at-risk populations and generates the hypothesis that scurvy is not a rare disease but rather a rare diagnosis. […] Without Vitamin C repletion, obvious clinical signs of scurvy will emerge. The first objective signs are typically follicular congestion and perifollicular hemorrhages. […] Scurvy is primarily a clinical diagnosis, supported by laboratory tests (serum ascorbic acid level, normal range, 0.6-2.0 mg/dL or 0.2-1.5 mg/dL depending upon the reference laboratory performing the test).

• #12 Scurvy: A Comprehensive Guide to Vitamin C Deficiency

  https://www.amritahospitals.org/kochi/blog/scurvy-what-you-need-to-know-to-identify-and-prevent-the-vitamin-c-deficiency

  Scurvy is a completely treatable condition when diagnosed early and managed appropriately. The focus of the treatment is replenishing the body’s vitamin C levels and addressing any complications caused by the deficiency. […] A comprehensive care plan also includes dietary improvements, supportive treatments, and monitoring for recovery. […] The primary treatment for scurvy is vitamin C replacement therapy. […] Improving the diet to include vitamin C-rich foods is essential for long-term recovery and prevention. […] Scurvy can lead to various complications, which require additional medical attention: […] Amrita Hospital, Kochi, provides comprehensive care for scurvy by combining expert medical treatments with patient education and counselling. […] Preventing scurvy is simple and revolves around maintaining adequate levels of vitamin C through a balanced diet and healthy lifestyle practices.

• #13 Scurvy (Vitamin C Deficiency) Treatment & Management: Approach Considerations, Ascorbic Acid, Diet

  https://emedicine.medscape.com/article/125350-treatment

  Because sudden death may occur in patients with scurvy, ensuring adequate vitamin C replenishment in patients with vitamin C deficiency is the hallmark of therapy. Restoration of body stores of vitamin C is essential to achieve complete resolution of symptoms. In most adult patients, provision of 250 mg of vitamin C four times a day for 1 week aids in achieving this goal. […] Identifying and treating comorbid nutritional deficiencies (eg, iron deficiency anemia, folate deficiency, other vitamin deficiencies) are integral parts of management. Provision of a balanced and liberal diet to meet the nutritional needs of the patient aids in recovery. […] Patients should take oral ascorbic acid at 100 mg 3-5 times a day until a total of 4 g is reached, and then they should decrease intake to 100 mg daily. Alternatively, ascorbic acid may be taken at 1 g/day for the first 3-5 days, followed by 300-500 mg/day for 1 week. Then, the recommended daily allowance is resumed.

• #14 Scurvy: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24318-scurvy

  Scurvy treatment is essential to avoid further complications. The condition is easily treatable by consuming more vitamin C. You should try to maintain a nutritious diet that includes one to two times your daily recommended amount of vitamin C. You can do so by adding fresh fruits and vegetables to every meal. […] Your healthcare provider may also recommend taking a vitamin C supplement until you feel better. Children with scurvy can take a supplement of up to 300 milligrams (mg) daily. Adults can take between 500 mg and 1000 mg. […] Most people feel better within 48 hours of treatment. You should be able to make a full recovery within two weeks. Some symptoms may take longer to fully clear up. Depending on the cause of your condition, your provider may refer you to a specialist for further treatment.

• #15 Scurvy (Vitamin C Deficiency) Treatment & Management: Approach Considerations, Ascorbic Acid, Diet

  https://emedicine.medscape.com/article/125350-treatment

  Because sudden death may occur in patients with scurvy, ensuring adequate vitamin C replenishment in patients with vitamin C deficiency is the hallmark of therapy. Restoration of body stores of vitamin C is essential to achieve complete resolution of symptoms. In most adult patients, provision of 250 mg of vitamin C four times a day for 1 week aids in achieving this goal. […] Identifying and treating comorbid nutritional deficiencies (eg, iron deficiency anemia, folate deficiency, other vitamin deficiencies) are integral parts of management. Provision of a balanced and liberal diet to meet the nutritional needs of the patient aids in recovery. […] Patients should take oral ascorbic acid at 100 mg 3-5 times a day until a total of 4 g is reached, and then they should decrease intake to 100 mg daily. Alternatively, ascorbic acid may be taken at 1 g/day for the first 3-5 days, followed by 300-500 mg/day for 1 week. Then, the recommended daily allowance is resumed.

• #16 Food Fighting and Curing Disease Series: Scurvy —

  https://foodmedcenter.org/food-fighting-and-curing-disease-series-scurvy/

  Scurvy is a disease that results from a vitamin C deficiency. It can lead to anemia, exhaustion, spontaneous bleeding, limb pain, swelling, and sometimes ulceration of the gums and loss of teeth. […] Scurvy is caused by not having enough vitamin C in your diet for at least 3 months. […] Scurvy is a progressive disease; the longer its left untreated, the more symptoms you’ll experience. […] Treatment involves administering vitamin C supplements. […] The recommended dosages are: Adults: 1 to 2 grams of vitamin C be administered daily for the first 2 to 3 days, followed by 500 mg per day for the next week. Afterward, a daily intake of 100 mg of vitamin C should be given for 1 to 3 months. […] Within 24-72 hours, people can expect to see an improvement in fatigue, lethargy, pain, anorexia, and confusion.

• #17 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/125350-overview

  Scurvy is a state of dietary deficiency of vitamin C (ascorbic acid). The only effective therapy for scurvy is vitamin C replacement. Thus, the goal of treatment is to saturate the body rapidly with ascorbic acid; at maximum doses, body stores become saturated in a few days. With proper treatment, bleeding stops within 24 hours, and perifollicular petechiae resolve in 2 weeks. […] Signs and symptoms include fatigue, malaise, anemia, myalgia, bone pain, easy bruising, swelling, petechiae, gingivitis, perifollicular hemorrhages, corkscrew hairs, and poor wound healing. If left untreated, the disease can progress to jaundice, neuropathy, hemolysis, seizures, and death. […] Typically, scurvy carries an excellent prognosis if diagnosed and treated appropriately. Fatigue, body aches, and anorexia generally improve within a day with appropriate therapy. Other manifestations of scurvy, including the following, tend to dramatically improve, resolving within weeks, if adequate oral vitamin C is given in daily doses to recoup body stores: Spontaneous bleeding stops within 1 day, Muscle and bone pain abate quickly, Bleeding and sore gums heal in 2-3 days, Ecchymoses heal within 12 days.

• #18 Scurvy (Vitamin C Deficiency): Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/125350-overview

  Scurvy is a state of dietary deficiency of vitamin C (ascorbic acid). The only effective therapy for scurvy is vitamin C replacement. Thus, the goal of treatment is to saturate the body rapidly with ascorbic acid; at maximum doses, body stores become saturated in a few days. With proper treatment, bleeding stops within 24 hours, and perifollicular petechiae resolve in 2 weeks. […] Signs and symptoms include fatigue, malaise, anemia, myalgia, bone pain, easy bruising, swelling, petechiae, gingivitis, perifollicular hemorrhages, corkscrew hairs, and poor wound healing. If left untreated, the disease can progress to jaundice, neuropathy, hemolysis, seizures, and death. […] Typically, scurvy carries an excellent prognosis if diagnosed and treated appropriately. Fatigue, body aches, and anorexia generally improve within a day with appropriate therapy. Other manifestations of scurvy, including the following, tend to dramatically improve, resolving within weeks, if adequate oral vitamin C is given in daily doses to recoup body stores: Spontaneous bleeding stops within 1 day, Muscle and bone pain abate quickly, Bleeding and sore gums heal in 2-3 days, Ecchymoses heal within 12 days.

• #19 Scurvy in the Modern Healthcare Setting: Prevention and Care — Elegant Care Villa

  https://elegantcarevilla.org/careblog/scurvy-in-the-modern-healthcare-setting-prevention-and-care

  The Cleveland Clinic states that 7.1% of Americans may have scurvy due to a vitamin C deficiency. […] This blog delves into the current knowledge about scurvy, including its prevention, clinical management, and the difficulties encountered in modern healthcare environments. […] By drawing attention to its reappearance, we underscore the necessity of taking proactive steps in its prevention and care. […] The main goal of scurvy prevention techniques is to ensure you get enough vitamin C. […] Educate the public through educational efforts on vitamin C’s role in avoiding scurvy. […] Vitamin C supplementation is essential when inadequate food intake. […] Regularly checking vitamin C levels and clinical symptoms is imperative to evaluating the effectiveness of treatment and making necessary adjustments to management tactics. […] In conclusion, the reappearance of scurvy in contemporary healthcare environments emphasizes the necessity of proactive prevention and prompt response.

• #20 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Scurvy (scorbutus) is the clinical disease caused by Vitamin C (ascorbic acid) deficiency with characteristic mucocutaneous and musculoskeletal manifestations. […] Scurvy can affect all age groups, both sexes, and all races. It remains surprisingly common worldwide in both developed and developing countries. […] The initial clinical features of scurvy are non-specific and include: General malaise and lethargy, Poor appetite and failure to thrive, Ill temper, Fever and tachypnoea. […] As the condition progresses, shortness of breath, wasting, anaemia, oedema, mucocutaneous changes, ocular and musculoskeletal symptoms develop. […] The recommended daily intake of Vitamin C in Australia and New Zealand is 45 mg/d. Pregnant and lactating women need 55-85 mg/d. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #21 scurvy | Taber’s Medical Dictionary

  https://www.tabers.com/tabersonline/view/Tabers-Dictionary/731385/0/scurvy?q=care

  Nutritional consultation is the cornerstone of patient care. […] Scurvy can be treated by providing about 1 gm of ascorbic acid daily, for about a week, usually in divided doses at meal time. […] Full recovery from scurvy is likely once nutritional supplements are consumed. Patients usually improve within a few days to a few weeks. When scurvy is left untreated, however, it may prove fatal.

• #22 Scurvy (Vitamin C Deficiency) Treatment & Management: Approach Considerations, Ascorbic Acid, Diet

  https://emedicine.medscape.com/article/125350-treatment

  A diet adequate in vitamin C can prevent the development of scurvy. Foods high in vitamin C include citrus fruits, especially grapefruits and lemons; berries and cantaloupe; and vegetables, including broccoli, spinach, green peppers, tomatoes, potatoes, cauliflower, and cabbage. […] The recommended daily allowance for vitamin C varies with the age of the individual. The current recommendation for adults is 120 mg daily, although a dose of 60 mg daily is all that is required to prevent scurvy. Some experts think the level should be as high as 200 mg daily to match the level present in 5 servings of fruits and vegetables daily, a diet shown to decrease cancer risk.

• #23 What Is Scurvy? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/scurvy/

  Scurvy is a disease thats caused by a deficiency in vitamin C (aka ascorbic acid), which is rare in the developed world. […] The symptoms of scurvy arent pleasant, but the disease is treatable and easy to recover from. […] Scurvy is generally easy to treat by increasing vitamin C levels. In mild cases, scurvy can be treated simply with vitamin Crich foods, Springer says. […] More severe cases, however, may require supplemental vitamin C, Springer says, and supplementation may also help you heal faster. […] All management of severe vitamin C deficiency should be under the direction of your healthcare team. […] To prevent scurvy, make sure youre getting enough vitamin C. […] Springer suggests shooting for five servings of a variety of fruits and vegetables each day. Thatll put you at around 200 mg of vitamin C, she says, which gives you a little more than the recommended daily intake, to make sure youre covered. […] Scurvy can typically be treated easily, but it may lead to long-term issues if it goes untreated. Depending on the severity of disease, scurvy can be very serious and even fatal, Samuels says.

• #24 Doctor—your septic patients have scurvy! | Critical Care | Full Text

  https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-1950-z

  Scurvy is a disease of antiquity described in Egyptian Hieroglyphics and responsible for the deaths of thousands of sailors during the Renaissance. […] Today, clinicians consider scurvy a very rare disease seen only in patients with extreme dietary deficiencies. […] They would undoubtedly be shocked to learn that about 40% of the patients in their ICU with septic shock have serum levels of vitamin C supporting a diagnosis of scurvy (11.3 u/mol/l). […] The most likely explanation for the acute vitamin C deficiency (acute scurvy) in patients with sepsis (and other critical illnesses) is a consequence of metabolic consumption. […] The inability to generate vitamin C makes humans very susceptible to dysfunction in a variety of biochemical pathways that are vital for surviving a critical illness such as sepsis.

• #25 Doctor—your septic patients have scurvy! | Critical Care | Full Text

  https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-1950-z

  Scurvy is a disease of antiquity described in Egyptian Hieroglyphics and responsible for the deaths of thousands of sailors during the Renaissance. […] Today, clinicians consider scurvy a very rare disease seen only in patients with extreme dietary deficiencies. […] They would undoubtedly be shocked to learn that about 40% of the patients in their ICU with septic shock have serum levels of vitamin C supporting a diagnosis of scurvy (11.3 u/mol/l). […] The most likely explanation for the acute vitamin C deficiency (acute scurvy) in patients with sepsis (and other critical illnesses) is a consequence of metabolic consumption. […] The inability to generate vitamin C makes humans very susceptible to dysfunction in a variety of biochemical pathways that are vital for surviving a critical illness such as sepsis.

• #26 Doctor—your septic patients have scurvy! | Critical Care | Full Text

  https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-1950-z

  In experimental models of sepsis, treatment with vitamin C limited the deleterious consequences of sepsis by multiple mechanisms, including attenuation of the proinflammatory response, enhancement of the endothelial and epithelial barrier function, and prevention of sepsis-associated coagulation abnormalities. […] These facts provide the scientific underpinning for treating septic patients with intravenous vitamin C. […] Based on our experience in treating over 300 patients with severe sepsis and septic shock, we believe that a dose of 1.5 g every 6 hours is adequate. […] We believe the clinical benefit of vitamin C in patients with sepsis is synergistically enhanced with the addition of low-dose corticosteroids and thiamine. […] This novel therapeutic intervention is being tested prospectively in a number of ongoing randomized controlled trials.

• #27 Scurvy and Critical Illness – Ascor® Ascorbic Acid Injection USP

  https://ascorhcp.com/scurvy-and-critical-illness

  Despite receiving standard ICU nutritional support, as many as 1/3 of critically ill patients may have ascorbic acid levels low enough to be scorbutic. […] Critically ill patients are at increased risk for Vitamin C depletion due to inflammation and increased metabolic consumption caused by oxidative stress and increased reactive oxygen species production. […] In addition to increased metabolic consumption of Vitamin C in critical illness, absorption of Vitamin C may also be negatively impacted. […] If your critically ill patients who are unable to take oral Vitamin C show signs and symptoms of scurvy, prescribe ASCOR, the only FDA-approved ascorbic acid injection. […] ASCOR is vitamin C indicated for the short term (up to 1 week) treatment of scurvy in adult and pediatric patients age 5 months and older for whom oral administration is not possible, insufficient or contraindicated. […] ASCOR is not indicated for treatment of vitamin C deficiency that is not associated with signs and symptoms of scurvy.

• #28 The British 'Limeys’ Were Right: A Short History of Scurvy | Health.mil

  https://health.mil/News/Articles/2022/01/10/The-British-Limeys-Were-Right-A-Short-History-of-Scurvy

  Today, scurvy still occurs in developed countries despite the widespread availability of multiple enriched and fortified foods. According to the National Institutes of Health, those most at risk for scurvy are: living alone, institutionalized with diets devoid of fresh fruits and vegetables, missing teeth or toothless, showing poor self-care, lacking social support, displaying destructive behaviors such alcoholism, drug abuse, or smoking, mentally or chronically ill.

• #29 Scurvy and the ageing population | British Dental Journal

  https://www.nature.com/articles/sj.bdj.2011.1061

  Sir, we write to you about two cases of scurvy which recently presented to our unit. […] Scurvy is easily treated with vitamin C supplements and the inclusion of fresh fruit and vegetables in a daily diet. […] Clinical symptoms coupled with low ascorbic acid levels led to a diagnosis of scurvy. The patient was started on vitamin C supplements and a review a week later showed complete resolution of the oral lesions. […] A diagnosis of scurvy with secondary anaemia was made. The patient was admitted for further investigations and vitamin C supplementation was commenced. […] As the UK’s population is ageing, with increasing numbers residing in care homes, we feel it is important for clinicians to be aware that scurvy could be affecting our patients and particularly those who may be visited on a domiciliary basis.

• #30 Facts About Scurvy – Ascor® Ascorbic Acid Injection USP

  https://ascoriv.com/ScurvyFacts

  Scurvy can be difficult to diagnose because early symptoms tend to be vague and nonspecific and can imitate a variety of more common disorders. The key feature of scurvy is bleeding, which can occur in any organ, and altered bone formation, which can cause bones to become brittle. […] It is important to treat scurvy because left untreated it is fatal. […] Scurvy can be caused by either insufficient dietary intake of Vitamin C or critical illness that is accompanied by inflammation and increased metabolic consumption of Vitamin C. The following groups may be at an increased risk for developing scurvy: People who suffer from alcohol abuse, Cancer patients, Critically ill patients, People with Crohn’s disease, People with Celiac disease, Children with autism spectrum disorder, Type I diabetics who have high Vitamin C requirements, People who suffer from drug addiction, Elderly people or indigent people who prepare their own food, People with end-stage renal disease on chronic hemodialysis, Individuals with restrictive diets, including food faddists, people with food allergies, eating disorders or oral aversion, Individuals with iron overload, which leads to wasting of Vitamin C by the kidneys, People with mental illness, People with severe intestinal malabsorption, Pneumonia (Community-Acquired), Smokers or people exposed to secondhand smoke, Septic patients.

• #31 Scurvy in the Intensive Care Unit

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8721699/

  Scurvy, caused by vitamin C deficiency, is a forgotten disease in the modern era of medicine. […] This case highlights the importance of considering severe nutritional deficiency in patients with underlying alcohol use who present with skin findings that may mimic those of a vasculitis. […] The patient had a known history of significant alcohol use; as such, a nutritional deficiency was considered as the etiology of his rash. […] It is therefore important to consider vitamin C deficiency in high-risk groups as it is very easily treated.

• #32 Facts About Scurvy – Ascor® Ascorbic Acid Injection USP

  https://ascoriv.com/ScurvyFacts

  Scurvy can be difficult to diagnose because early symptoms tend to be vague and nonspecific and can imitate a variety of more common disorders. The key feature of scurvy is bleeding, which can occur in any organ, and altered bone formation, which can cause bones to become brittle. […] It is important to treat scurvy because left untreated it is fatal. […] Scurvy can be caused by either insufficient dietary intake of Vitamin C or critical illness that is accompanied by inflammation and increased metabolic consumption of Vitamin C. The following groups may be at an increased risk for developing scurvy: People who suffer from alcohol abuse, Cancer patients, Critically ill patients, People with Crohn’s disease, People with Celiac disease, Children with autism spectrum disorder, Type I diabetics who have high Vitamin C requirements, People who suffer from drug addiction, Elderly people or indigent people who prepare their own food, People with end-stage renal disease on chronic hemodialysis, Individuals with restrictive diets, including food faddists, people with food allergies, eating disorders or oral aversion, Individuals with iron overload, which leads to wasting of Vitamin C by the kidneys, People with mental illness, People with severe intestinal malabsorption, Pneumonia (Community-Acquired), Smokers or people exposed to secondhand smoke, Septic patients.

• #33 Scurvy: A Comprehensive Guide to Vitamin C Deficiency

  https://www.amritahospitals.org/kochi/blog/scurvy-what-you-need-to-know-to-identify-and-prevent-the-vitamin-c-deficiency

  By ensuring proper nutrition and addressing risk factors, individuals can avoid this entirely preventable condition. […] Early diagnosis and treatment are crucial for effective recovery and to prevent complications. […] With proper medical care and lifestyle modifications, scurvy is entirely preventable and treatable.

• #34 shropshireguineapiggery – Scurvy & Vit C

  https://www.shropshireguineapiggery.co.uk/caring-for-your-guinea-pig/scurvy-vit-c/

  With good owner education giving a Guinea pig the correct amount of Veggies, many guinea pigs will do well after a diagnosis of scurvy. […] How to make sure you are giving your guinea pig Vitamin C to prevent Scurvy. […] Guinea pigs should have Vegetables every single day, to ensure a stable level of Vitamin C in your guinea pig. […] One large chunk of Pepper contains all the Vitamin C a guinea pig needs a day, but it is always appreciated by your Guinea pig to give them different veg and a varied diet. Even we get tired of eating the same thins day after day. […] Vitamin C has a half-life of approximately 10 days in vegetables. This means that from the point of being harvested, the amount of viable Vitamin C contained within the food decreases by half every 10 days. Always feed vegetables, greens and fruit as fresh as possible for maximum nutrient content.

• #35 Scurvy (vitamin C deficiency)

  https://dermnetnz.org/topics/scurvy

  Scurvy (scorbutus) is the clinical disease caused by Vitamin C (ascorbic acid) deficiency with characteristic mucocutaneous and musculoskeletal manifestations. […] Scurvy can affect all age groups, both sexes, and all races. It remains surprisingly common worldwide in both developed and developing countries. […] The initial clinical features of scurvy are non-specific and include: General malaise and lethargy, Poor appetite and failure to thrive, Ill temper, Fever and tachypnoea. […] As the condition progresses, shortness of breath, wasting, anaemia, oedema, mucocutaneous changes, ocular and musculoskeletal symptoms develop. […] The recommended daily intake of Vitamin C in Australia and New Zealand is 45 mg/d. Pregnant and lactating women need 55-85 mg/d. […] Most symptoms of scurvy resolve rapidly within 24-72 hours of starting Vitamin C supplements. Bone changes may take several weeks to resolve. Full recovery is usual within 1-3 months. Loss of teeth and sequelae from haemorrhage are the only permanent disabilities. […] If untreated, scurvy can cause sudden death.

• #36 Vitamin C Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493187/

  Initially, nonspecific symptoms of scurvy emerge after 4 to 12 weeks of insufficient intake of vitamin C. Patients might present with fatigue, malaise, lethargy, and anorexia. […] Treating scurvy involves consuming sufficient fruits and vegetables to prevent recurrences and addressing the underlying causes of malnutrition that lead to vitamin C deficiency. […] A multidisciplinary approach involving physicians, advanced care practitioners, nurses, dieticians, dentists, dental hygienists, and pharmacists is vital for providing patient-centered care, enhancing outcomes, and maintaining patient safety. Each healthcare team member should possess specialized skills in assessing, diagnosing, and managing vitamin C deficiency. […] Effectively addressing vitamin C deficiency demands the coordinated efforts of an interprofessional team.

• #37 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal

  https://amj.amegroups.org/article/view/9986/html

  Despite its perception as a historical disease, scurvy occurs in the modern era. […] Adequate supplementation and dietary education are essential to prevent recurrence, and interdisciplinary support is necessary to improve nutrition access to patients experiencing barriers to care. […] This case highlights the contributions of dialysis and food insecurity to vitamin C deficiency, additionally reflecting the specific dermatologic manifestations of scurvy and the importance of continuing vitamin C supplementation after initial treatment. […] Healthcare providers should maintain a high index of suspicion for nutrient deficiencies and consider a detailed dietary history, clinical nutritionist engagement, and selective laboratory testing when treating high-risk populations presenting with unexplained bleeding, new neuropsychiatric symptoms, or skin and body hair changes. […] Vitamin C deficiency is easily reversed with adequate supplementation but can have severe consequences if left untreated.

• #38 Scurvy in the Modern Healthcare Setting: Prevention and Care — Elegant Care Villa

  https://elegantcarevilla.org/careblog/scurvy-in-the-modern-healthcare-setting-prevention-and-care

  The Cleveland Clinic states that 7.1% of Americans may have scurvy due to a vitamin C deficiency. […] This blog delves into the current knowledge about scurvy, including its prevention, clinical management, and the difficulties encountered in modern healthcare environments. […] By drawing attention to its reappearance, we underscore the necessity of taking proactive steps in its prevention and care. […] The main goal of scurvy prevention techniques is to ensure you get enough vitamin C. […] Educate the public through educational efforts on vitamin C’s role in avoiding scurvy. […] Vitamin C supplementation is essential when inadequate food intake. […] Regularly checking vitamin C levels and clinical symptoms is imperative to evaluating the effectiveness of treatment and making necessary adjustments to management tactics. […] In conclusion, the reappearance of scurvy in contemporary healthcare environments emphasizes the necessity of proactive prevention and prompt response.

• #39 Persistent scurvy after vitamin C supplementation in a high-risk patient: a case report – Oles – AME Medical Journal

  https://amj.amegroups.org/article/view/9986/html

  Despite its perception as a historical disease, scurvy occurs in the modern era. […] Adequate supplementation and dietary education are essential to prevent recurrence, and interdisciplinary support is necessary to improve nutrition access to patients experiencing barriers to care. […] This case highlights the contributions of dialysis and food insecurity to vitamin C deficiency, additionally reflecting the specific dermatologic manifestations of scurvy and the importance of continuing vitamin C supplementation after initial treatment. […] Healthcare providers should maintain a high index of suspicion for nutrient deficiencies and consider a detailed dietary history, clinical nutritionist engagement, and selective laboratory testing when treating high-risk populations presenting with unexplained bleeding, new neuropsychiatric symptoms, or skin and body hair changes. […] Vitamin C deficiency is easily reversed with adequate supplementation but can have severe consequences if left untreated.

• #40 A doctor on vitamin C deficiency in the modern age

  https://harvardpublichealth.org/policy-practice/a-doctor-on-vitamin-c-deficiency-in-the-modern-age/

  The ships botanist knew about scurvy preventatives limes, fresh greens, sauerkraut, raw meat, and beer brewed with spruce needlesbut his knowledge was initially scorned. […] Although scurvy was mostly eradicated centuries ago, its simple cure is once again neglected today, in a system focused on making money with more complicated and costly diagnoses. […] Doctors learn little about nutrition in their medical education, so they often cannot recognize, diagnose, and treat nutritional deficiencies. […] The solution is obvious: testing for vitamin deficiencies and then treating them. We need to consider the whole patient. No one should suffer from easily treated diseases of centuries past.

• #41 scurvy | Taber’s Medical Dictionary

  https://www.tabers.com/tabersonline/view/Tabers-Dictionary/731385/0/scurvy?q=care

  Nutritional consultation is the cornerstone of patient care. […] Scurvy can be treated by providing about 1 gm of ascorbic acid daily, for about a week, usually in divided doses at meal time. […] Full recovery from scurvy is likely once nutritional supplements are consumed. Patients usually improve within a few days to a few weeks. When scurvy is left untreated, however, it may prove fatal.

• #42 Scurvy – Don’t Forget the Bubbles

  https://dontforgetthebubbles.com/scurvy/

  Scurvy, or vitamin C deficiency, is a disease of malnutrition. […] Scurvy is rare in higher income countries and therefore often forgotten as a potential differential diagnosis. […] In children of the developed world, risk factors for developing scurvy are severe dietary restriction of fruit and vegetables. […] Scurvy is a clinical diagnosis based on typical signs and symptoms alongside a dietary history of restrictive vitamin C intake for at least 1-3 months. […] The diagnosis is, in the main, a clinical one. When signs and symptoms respond to dietary changes or supplementation with Vitamin C, you know you are on the right track. […] Vitamin C supplementation orally for children with 100-300mg for one month or until full recovery. […] Referral to a dietician for dietary education is imperative. […] Scurvy is a preventable, easily treatable disease that, due to its non-specific symptoms, is often misdiagnosed or carries a delay in diagnosis, with patients presenting to healthcare professionals on multiple occasions. An excellent nutritional history is critical to diagnosis.

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