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• #1 Lung cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620

  Lung cancer typically doesn’t cause symptoms early on. Symptoms of lung cancer usually happen when the disease is advanced. […] Signs and symptoms of lung cancer that happen in and around the lungs may include: A new cough that doesn’t go away. Chest pain. Coughing up blood, even a small amount. Hoarseness. Shortness of breath. Wheezing. […] Signs and symptoms that happen when lung cancer spreads to other parts of the body may include: Bone pain. Headache. Losing weight without trying. Loss of appetite. Swelling in the face or neck. […] Lung cancer can cause complications, such as: Shortness of breath. People with lung cancer can experience shortness of breath if cancer grows to block the major airways. Lung cancer also can cause fluid to collect around the lungs and heart. The fluid makes it harder for the affected lung to expand fully when you inhale.

• #2 Lung Cancer Signs & Symptoms | American Cancer Society

  https://www.cancer.org/cancer/types/lung-cancer/detection-diagnosis-staging/signs-symptoms.html

  Most lung cancers do not cause any symptoms until they have spread, but some people with early lung cancer do have symptoms. […] The most common symptoms of lung cancer are: A cough that does not go away or gets worse, Coughing up blood or rust-colored sputum (spit or phlegm), Chest pain that is often worse with deep breathing, coughing, or laughing, Hoarseness, Loss of appetite, Unexplained weight loss, Shortness of breath, Feeling tired or weak, Infections such as bronchitis and pneumonia that dont go away or keep coming back, New onset of wheezing. […] If lung cancer spreads to other parts of the body, it may cause: Bone pain (like pain in the back or hips), Nervous system changes (such as headache, weakness or numbness of an arm or leg, dizziness, balance problems, or seizures), from cancer spread to the brain, Yellowing of the skin and eyes (jaundice), from cancer spread to the liver, Swelling of lymph nodes (collection of immune system cells) such as those in the neck or above the collarbone.

• #3 Lung Cancer: Types, Stages, Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/4375-lung-cancer

  A cough or pneumonia that keeps coming back after treatment can sometimes be an early sign of lung cancer (though it can also be a sign of less serious conditions). The most common signs of lung cancer include a persistent or worsening cough, shortness of breath, chest pain, hoarseness or unexplained weight loss. […] Depending on where in your lungs cancer starts, some of these symptoms can happen early (in stages I or II) but often they dont happen until cancer has progressed to later stages. […] Cancer can grow in your body for a long time years before you know its there. Lung cancer often doesnt cause symptoms in early stages. […] How fast lung cancer spreads depends on the type. Of the main types, small cell lung cancer tends to spread faster than non-small cell lung cancer. By the time lung cancer is found, it may have already started spreading to lymph nodes or other organs.

• #4 How Quickly Does Lung Cancer Progress?

  https://www.verywellhealth.com/lung-cancer-progression-5218567

  Still, lung cancer continues to be a very serious illness, especially when diagnosed at a later stage. […] Most cases of lung cancer are not diagnosed until they are at stage 3 or stage 4. A 2020 study of 9,876 people found diagnosis occurred at stage 4 in 46.6% of the cases and some people still had few or no symptoms. […] When lung cancer is diagnosed at stage 4, the five-year survival is 3% for small cell lung cancer and 9% for non-small cell lung cancer. […] Along with other lung cancer symptoms, people with advanced lung cancer commonly experience pain, shortness of breath, and coughing. […] As someone nears death from lung cancer, they may experience symptoms such as increased sleepiness, weakness, and confusion.

• #5

  https://www.nhs.uk/conditions/lung-cancer/symptoms/

  There are usually no signs or symptoms of lung cancer in the early stages. Symptoms develop as the condition progresses. […] The main symptoms of lung cancer include: a cough that does not go away after 3 weeks, a long-standing cough that gets worse, chest infections that keep coming back, coughing up blood, an ache or pain when breathing or coughing, persistent breathlessness, persistent tiredness or lack of energy, loss of appetite or unexplained weight loss. […] Less common symptoms of lung cancer include: changes in the appearance of your fingers, such as becoming more curved or their ends becoming larger (this is known as finger clubbing), difficulty swallowing (dysphagia) or pain when swallowing, wheezing, a hoarse voice, swelling of your face or neck, persistent chest or shoulder pain.

• #6 18 Top Lung Cancer Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/lung-cancer/lung-cancer-symptoms.html

  Lung cancer symptoms vary from person to person. Some people with lung cancer don’t have any symptoms. Often, symptoms are easily confused with common respiratory illnesses such as bronchitis or pneumonia, delaying an accurate diagnosis. […] The most common symptoms of lung cancer include: Cough that does not go away and gets worse over time, Chest pain that is constant and often made worse by deep breathing, coughing or laughing, Arm or shoulder pain, Coughing up blood or rust-colored phlegm, Shortness of breath, Wheezing, Hoarseness, Infections like pneumonia or bronchitis that do not go away or come back often, Swelling of the neck and face, Loss of appetite and/or weight loss, Feeling weak or tired, Widening of the fingertips and nailbed also known as clubbing. […] If lung cancer spreads to other parts of the body, it may cause: Bone pain, Arm or leg weakness or numbness, Headache, dizziness or seizure, Balance problems or an unsteady gait, Jaundice (yellow coloring) of skin and eyes, Swollen lymph nodes in the neck or shoulder. […] These symptoms do not always mean you have lung cancer. However, it is important to discuss any lung cancer symptoms with your doctor, since they may also signal other health problems.

• #7 How Quickly Does Lung Cancer Progress?

  https://www.verywellhealth.com/lung-cancer-progression-5218567

  Lung cancer is one of the most common types of cancer in the United States and a leading cause of cancer deaths. However, the timeline of how the disease progresses can vary based on several factors. There’s no single answer that applies to all people. […] The early stages of lung cancer often have no obvious symptoms. By the time symptoms are noticeable, cancer may have already progressed and spread beyond the lungs, and the symptoms may reflect the effects it is having elsewhere in the body. […] The symptoms of lung cancer can include: Persistent cough, Coughing up blood, Chest pain, Shortness of breath, Wheezing (whistling sound while breathing), Unintentional weight loss, Feeling tired. […] Additional signs common in end stage lung cancer can include: Pain, Increased sleeping, Restlessness, Decreased food/fluid intake, Mental confusion.

• #8 Lung Cancer Signs & Symptoms | American Cancer Society

  https://www.cancer.org/cancer/types/lung-cancer/detection-diagnosis-staging/signs-symptoms.html

  Many of these symptoms are more likely to be caused by something other than lung cancer. Still, if you have any of these problems, its important to see your doctor right away so the cause can be found and treated, if needed. […] If you go to your doctor when you first notice lung cancer symptoms, your cancer might be diagnosed at an earlier stage, when treatment is more likely to be effective.

• #9 Lung cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620

  Coughing up blood. Lung cancer can cause bleeding in the airway. This can cause you to cough up blood. Sometimes bleeding can become severe. Treatments are available to control bleeding. […] Pain. Advanced lung cancer that spreads can cause pain. It may spread to the lining of a lung or to another area of the body, such as a bone. Tell your healthcare professional if you experience pain. Many treatments are available to control pain. […] Cancer that spreads to other parts of the body. Lung cancer often spreads to other parts of the body. Lung cancer may spread to the brain and the bones. […] Once lung cancer has spread beyond the lungs, it’s generally not curable. Treatments are available to decrease symptoms and to help you live longer.

• #10 Symptoms of metastatic lung cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/lung-cancer/metastatic/symptoms

  Metastatic lung cancer means that the cancer has spread from where it started in the lung. It is also called advanced lung cancer. […] Possible symptoms of lung cancer are: a new cough or a cough most of the time, breathlessness, unexplained weight loss, ongoing chest infections, coughing up blood, a hoarse voice, difficulty swallowing, changes in the shape of your fingers and nails called finger clubbing, swelling of the face caused by a blockage of a main blood vessel (superior vena cava obstruction), a loss of appetite, tiredness and weakness. […] Lung cancer can also sometimes cause a build up of fluid between the two layers covering the lung (a pleural effusion). This can cause a cough and breathlessness. […] You may feel very breathless if the cancer is blocking your airway or if there is fluid around your lung.

• #11 Stage 4 Lung Cancer: Metastatic Symptoms, Treatment, Survival

  https://www.cancercenter.com/cancer-types/lung-cancer/stages/stage-iv-lung-cancer

  Stage 4 lung cancer, also called metastatic lung cancer, is an advanced disease. In stage 4 lung cancer, the cancer has spread from the lung, where it originated, to other parts of the body. […] The following lung cancer symptoms may accompany any stage, although theyre more likely to occur as the cancer progresses: Persistent, worsening cough, Hemoptysis (coughing up blood), Blood in spit, Chest pain that may be aggravated by deep breaths, coughing, laughing, Hoarse voice, Poor appetite, Unintentional weight loss, Shortness of breath, Fatigue or weakness, Wheezing, Frequent infections such as bronchitis and pneumonia. […] Other symptoms that may develop as a result of the lung cancer metastasizing to other parts of the body include: Headaches, weakness or numbness in a limb, dizziness, balance issues or seizures (if the cancer has spread to the brain), Jaundice (if the cancer has spread to the liver), Pain in the bones of the back or hips, Swollen lymph nodes in the neck.

• #12 Symptoms of metastatic lung cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/lung-cancer/metastatic/symptoms

  Other symptoms of metastatic lung cancer depend on where the cancer is in the body. […] The most common symptom if cancer has spread to the lymph nodes is that they are usually bigger than normal. […] Cancer that has spread to the brain might cause any of the following symptoms: memory problems, mood or personality changes, seizures, confusion, severe headaches, often with sickness, weakness of an arm or leg. […] You might have any of the following symptoms if your cancer has spread to the liver: discomfort or pain on the right side of your tummy (abdomen), feeling sick, poor appetite and weight loss, a swollen tummy (called ascites), yellowing of the skin and whites of the eyes (jaundice), itchy skin. […] Cancer that has spread to the bone can cause: pain (this can be lower back pain if the cancer cells are in the spinal bones), weaker bones (they may get damaged or break more easily), raised calcium levels in your blood (causing dehydration and confusion).

• #13 Lung Cancer: Types, Stages, Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/4375-lung-cancer

  Lung cancer usually starts in the airways (bronchi or bronchioles) or small air sacs (alveoli) of your lungs. It can then spread to other organs. […] Most lung cancer symptoms look similar to other, less serious illnesses. Many people dont have symptoms until the disease is advanced, but some people have symptoms in the early stages. For those who do experience symptoms, it may only be one or a few of these: A cough that doesnt go away or gets worse over time. Trouble breathing or shortness of breath (dyspnea). Chest pain or discomfort. Wheezing. Coughing up blood (hemoptysis). Hoarseness. Loss of appetite. Unexplained weight loss. Unexplained fatigue (tiredness). Shoulder pain. Swelling in the face, neck, arms or upper chest (superior vena cava syndrome). Small pupil and drooping eyelid in one eye with little or no sweating on that side of your face (Horners syndrome).

• #14 Signs & Symptoms | LUNGevity Foundation

  https://www.lungevity.org/lung-cancer-basics/signs-symptoms

  Trouble swallowing. […] Swelling in the face and/or veins in the neck. […] Lung cancer that spreads may cause other symptoms, like pain in the back or other bones or weakness in the arms or legs. If it spreads to the brain, it may cause headaches, seizures, dizziness, memory problems, or speech difficulties. […] Small cell lung cancer patients may also present with unique symptoms because small cell lung cancer tumors secrete hormones. These symptoms are called paraneoplastic syndromes. An example of these is SIADH, syndrome of inappropriate anti-diuretic hormone secretion, which can lead to low blood sodium levels because the body retains fluid.

• #15 Clinical manifestations of lung cancer – UpToDatePresenting_symptoms_lung_ca.htm

  https://www.uptodate.com/contents/clinical-manifestations-of-lung-cancer/print

  Cough is present in 50 to 75 percent of lung cancer patients at presentation and occurs most frequently in patients with squamous cell and small cell carcinomas because of their tendency to involve central airways. […] Shortness of breath is a common symptom in patients with lung cancer at the time of diagnosis, occurring in approximately 25 to 40 percent of cases. […] Patients with lung cancer may also present with nonspecific symptoms that suggest the presence of advanced-stage disease. These symptoms include but are not limited to weight loss, anorexia, weakness, and fatigue. […] During the course of their disease, approximately 10 to 15 percent of patients who have lung cancer will have a malignant pleural effusion. […] The most frequent sites of distant metastasis are the liver, adrenal glands, bones, and brain. […] Metastasis from lung cancer to bone is frequently symptomatic. Pain in the back, chest, or extremity and elevated levels of serum alkaline phosphatase are usually present in patients who have bone metastasis. […] In patients with NSCLC, the frequency of brain metastasis is greatest with adenocarcinoma and least with squamous cell carcinoma. […] In patients with SCLC, metastasis to brain is present in approximately 20 to 30 percent of patients at presentation. […] Symptomatic hepatic metastases are uncommon early in the course of disease. […] Hypercalcemia in patients with lung cancer may arise from tumor secretion of parathyroid hormone-related protein or, less commonly, from extensive bony metastases. […] The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is frequently caused by SCLC and results in hyponatremia. Approximately 10 percent of patients who have SCLC exhibit SIADH. […]

• #16 Lung Cancer Stages | Cooper University Health Care

  https://www.cooperhealth.org/services/lung-cancer/stages

  The symptoms of stage I lung cancer may include: Persistent or worsening cough, Coughing up blood or blood-streaked mucus, Hoarseness, Pain in the chest, rib or shoulder, Weight loss, Fatigue, Lung infections like bronchitis that don’t improve with treatment or come back. […] The symptoms of stage II lung cancer may include: Persistent cough, Coughing up blood or blood-streaked mucus, Shortness of breath or wheezing, Lung infections like bronchitis or pneumonia that don’t improve with treatment, Hoarseness, Pain in the chest, Weight loss, Fatigue. […] The symptoms of stage III lung cancer may include: Persistent cough, Coughing up blood or blood-streaked mucus, Shortness of breath or wheezing, Hoarseness, Pain in the chest, Weight loss, Fatigue. […] The symptoms of stage IV lung cancer may include: Persistent cough, Coughing up blood or blood-streaked mucus, Shortness of breath or wheezing, Hoarseness, Pain in the chest, Weight loss, Fatigue.

• #17 Stage 1 lung cancer symptoms: What they are, treatment, and more

  https://www.medicalnewstoday.com/articles/stage-1-lung-cancer-symptoms

  Stage 1 lung cancer does not always cause symptoms. When they do occur, stage 1 lung cancer symptoms can include shortness of breath, a persistent cough, coughing up blood or blood-stained phlegm, and more. […] People with stage 1 lung cancer may not have any symptoms at all. […] Some people with stage 1 lung cancer will notice symptoms, but they vary from person to person. […] The common symptoms of lung cancer include: shortness of breath when doing daily tasks, persistent cough that has not disappeared after 23 weeks, coughing up blood or blood-stained mucus. […] Additional symptoms of lung cancer include: appetite loss, weight loss, general fatigue, shoulder, chest, or back pain, hoarse voice, harsh sounds with each breath, or stridor, recurrent lung problems, such as bronchitis or pneumonia.

• #18 Stage 1 lung cancer symptoms: What they are, treatment, and more

  https://www.medicalnewstoday.com/articles/stage-1-lung-cancer-symptoms

  However, at this point, the lung cancer may have progressed to later stages. […] Most lung cancers do not cause symptoms until they have spread. […] Symptoms usually develop slowly after the lung cancer has been growing for some time. This results in a majority of patients with lung cancer having advanced disease by the time they see a doctor. […] People do not typically experience symptoms in stage 1 lung cancer. By the time a person notices symptoms, their cancer may have reached more advanced stages. […] However, people should seek medical help if they experience shortness of breath, a persistent cough, or coughing up blood or blood-tinged phlegm.

• #19 Lung Cancer Symptoms, Screening, Stages | Sarah Cannon

  https://sarahcannon.com/for-patients/learn-about-cancer/lung-cancer/

  Using TNM, your doctor will diagnose your cancer according to one of the following stages: Occult Stage- Lung cancer cells are found in sputum or in a sample of fluid collected during bronchoscopy, but a tumor cannot be seen in the lung. Stage 0: Cancer cells are found only in the innermost lining of the lung or airway. A Stage 0 tumor is also called carcinoma in situ. The tumor is not invasive. Stage 1: This is an invasive cancer. It has grown through the innermost lining of the lung. There are two categories: IA (≤ 2cm) and IB (>2cm, ≤ 3cm). The difference is in the size of the tumor. Stage 2: Stage 2 is more invasive than Stage 1. Cancer cells are in nearby lymph nodes. Or, the lung tumor has invaded the chest wall, diaphragm, pleura, or main bronchus. There are two categories, IIA and IIB. The main difference is where the cancer has spread and how large the tumor is. Stage 3A: The tumor is large (>7cm) or invades surrounding structures or has spread to the lymph nodes in the neck, above the clavicle, or near the other lung. Stage 3B: The tumor may be any size and has invaded nearby organs such as the heart, esophagus, or trachea. Stage 4: Malignant growths may be found in the other lung. Cancer cells may also exist in other parts of your body, like the brain, liver or bone. This is the most advanced stage of lung cancer.

• #20 Lung Cancer Types & Stages | Icon Cancer Centre Singapore

  https://iconcancercentre.sg/en/cancer/lung/

  Lung cancer can be described in stages depending on how early or advanced the cancer is: early stage (stages I and II), locally advanced (stage III) and metastatic lung cancer (stage IV). […] Some common symptoms of lung cancer include: Difficulty breathing, wheezing or coughing, Difficulty swallowing, Coughing up blood, Unexplained tiredness or fatigue, Swollen face or enlarged veins in the neck, A chronic (ongoing) cough that doesn’t go away, Shoulder or chest pain that may be worse with breathing, Chronic infections such as bronchitis or pneumonia. […] Some lung cancers can also cause a collection of specific symptoms which are termed syndromes. Syndromes which have been associated with lung cancer include: Superior Vena Cava (SVC) syndrome the SVC is a large blood vessel that carries blood away from the head and arms to the heart. Tumours near the lung area can press against this large blood vessel causes swelling in the face and neck, chest and upper arm area.

• #21 Lung Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482357/

  Superior vena cava syndrome with dilated neck veins, edema of the face, neck, and upper extremities, and a plethoric appearance is a common feature of small cell lung cancer. […] Brain metastasis is another common feature of lung cancer in small cell lung cancers (SCLC) and non-small cell lung cancers (NSCLC). In SCLC, brain metastases may be present in as high as 20 to 30% of the patients at diagnosis.

• #22 Controlling symptoms of lung cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/controlling-symptoms-of-lung-cancer

  Symptoms can develop quickly. They include: a feeling of fullness in the face when you bend over, breathlessness, headaches, swelling in the face, neck, arms, hands, and veins in the chest, feeling dizzy, changes in your eyesight. […] When the cancer is causing a blockage or narrowing in the airways, doctors may use the following treatments to relieve symptoms.

• #23 Lung Cancer – Lung and Airway Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/lung-and-airway-disorders/tumors-of-the-lungs/lung-cancer

  If the cancer spreads throughout the lungs, the levels of oxygen in the blood become low, causing shortness of breath and eventually enlargement of the right side of the heart and possible heart failure (a disorder called cor pulmonale). […] Lung cancer may grow into certain nerves in the neck, causing a droopy eyelid, small pupil, and reduced perspiration on one side of the face together these symptoms are called Horner syndrome. […] Cancers at the top of the lung may grow into the nerves that supply the arm, making the arm or shoulder painful, numb, and weak. […] When the tumor grows into nerves in the center of the chest, the nerve to the voice box may become damaged, making the voice hoarse, and the nerve to the diaphragm may become damaged, causing shortness of breath and low blood oxygen levels.

• #24 Clinical manifestations of lung cancer – UpToDatePresenting_symptoms_lung_ca.htm

  https://www.uptodate.com/contents/clinical-manifestations-of-lung-cancer/print

  Symptomatic hepatic metastases are uncommon early in the course of disease. […] Hypercalcemia in patients with lung cancer may arise from tumor secretion of parathyroid hormone-related protein or, less commonly, from extensive bony metastases. […] The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is frequently caused by SCLC and results in hyponatremia. Approximately 10 percent of patients who have SCLC exhibit SIADH. […] Paraneoplastic effects of tumor are remote effects that are not related to the direct invasion, obstruction, or metastasis. […] These diverse neurologic manifestations include, but are not limited to, Lambert-Eaton myasthenic syndrome (LEMS), cerebellar ataxia, sensory neuropathy, limbic encephalitis, encephalomyelitis, autonomic neuropathy, retinopathy, and opsomyoclonus.

• #25 Lung Cancer Types & Stages | Icon Cancer Centre Singapore

  https://iconcancercentre.sg/en/cancer/lung/

  Cushing Syndrome adrenal glands in the body may produce too much cortisol (due to cancer cells producing specific hormones), this can lead to weight gain, as well as symptoms of dizziness/tiredness and weakness. […] SIADH (Syndrome of inappropriate anti-diuretic hormone) cancer cells can make a hormone which encourage the kidneys to hold onto water, reducing the amount of salt in the blood. Symptoms can include; cramps and muscle weakness, tiredness, nausea and/or vomiting. In severe cases without treatment, seizures and coma may occur.

• #26 How Does Lung Cancer Progress? Timeline & What To Expect – O2 Healthcare Group

  https://o2healthcaregroup.com/news-and-articles/how-does-lung-cancer-progress-timeline-what-to-expect/

  Lung cancer is the most prevalent type of cancer globally. While smoking cigarettes is the leading risk factor, it can also impact non-smokers. Hence, lung cancer can also be linked to cannabis smoking, secondhand smoke, air pollution and toxic exposure. […] In many cases, lung cancer patients do not have symptoms until the disease has metastasised (spread) to other body parts. […] Lung cancer’s early stages frequently have no noticeable symptoms. By the time symptoms become apparent, cancer may have already advanced and spread outside the lungs, and the symptoms may reflect its impacts on other body parts. The symptoms of lung cancers are: Persistent cough, Coughing up blood, Chest pain, Shortness of breath, Wheezing, Unintentional weight loss, Feeling tired. […] While each type of lung cancer has its expected prognosis, lung cancer outcomes are generally better when they are discovered at an earlier stage.

• #27 Lung Cancer Stages, Prognosis, and Progression

  https://www.verywellhealth.com/lung-cancer-progression-5221706

  Lung cancer prognosis tends to be better for people diagnosed in earlier stages of the disease. […] Lung cancer is staged according to how large the tumor is and how far it has spread: Localized lung cancers are those that are still confined to the lung. […] People who are younger and/or diagnosed before the cancer spreads outside the lung generally have a better prognosis. […] The five-year relative survival rate describes how many people with lung cancer will still be alive after diagnosis. […] Lung cancer often progresses quickly, depending on the type of lung cancer diagnosed. Small cell lung cancer spreads more rapidly than non-small cell lung cancer. On average, lung cancers double in size in approximately four to five months. […] If lung cancer is progressing and/or spreading to other areas of the body, you may notice physical changes, depending on the area of the body where the cancer cells have metastasized. You may feel more fatigued, have a persistent cough, feel shortness of breath, feel nauseous, or experience pain in other parts of the body (e.g., abdomen).

• #28 Lung Cancer Progression Rate | Pintas & Mullins

  https://www.pintas.com/practice-areas/lung-cancer/how-quickly-does-lung-cancer-progress

  Though we do not have the ability to measure when lung cancer started in a patient, experts say it takes approximately three to six months for most lung cancers to double in size. […] Lung cancer is especially deadly due to the fact that it typically exhibits no immediately discernible symptoms. […] Lung cancer can progress so silently that it can take years for it to grow to half an inch in size, or large enough to be seen by an x-ray. […] Non-small cell lung cancer grows and spreads more slowly than small cell lung cancer. […] Small cell lung cancer grows and spreads quickly. Nearly 70% of patients diagnosed with SCLC have cancer that has already spread. […] Lung cancer is often difficult to detect until it has progressed. […] Receiving a lung cancer diagnosis and seeing how quickly lung cancer can progress is frightening.

• #29 How Does Lung Cancer Progress? Timeline & What To Expect – O2 Healthcare Group

  https://o2healthcaregroup.com/news-and-articles/how-does-lung-cancer-progress-timeline-what-to-expect/

  Approximately 15% of instances of lung cancer are small cell lung cancer (SCLC), often known as “oat cell cancer”. Smokers are more prone to developing SCLC. Since it spreads so quickly, it is aggressive. […] In about 84% of cases where SCLC is identified, a metastatic condition is already involved. This indicates that the cancer has spread to different body parts. […] When lung cancer spreads, lymph nodes are frequently the first parts of the body where the cancer’s cells are discovered. […] Another common organ that lung cancer cells attack is the liver. Up to 20% of patients with small-cell lung cancer and 4% of those with NSCLC may develop liver metastases. […] When lung cancer spreads to the bones, it can cause significant pain and fractures. Bone metastasis from lung cancer will occur in 30–40% of patients with advanced lung cancer.

• #30 Small Cell Lung Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482458/

  Lung cancer is the second most diagnosed cancer in the United States. […] It is the leading cause of cancer death in both men and women, accounting for approximately a quarter of all cancer deaths. […] Symptoms are usually rapid-onset and begin 8 to 12 weeks before presentation. Signs and symptoms depend on the location and bulk of the primary tumor. They may include a cough, wheezing, and hemoptysis. Local intrathoracic tumor growth can affect the superior vena cava (resulting in superior vena cava syndrome), chest wall, or esophagus. Extrapulmonary distant spread can present with neurological problems, recurrent nerve pain, fatigue, and anorexia. Nearly 60% of patients present with metastatic disease. Most common sites of metastases include the brain, liver, adrenal glands, bone, and bone marrow. If left untreated, SCLC is characterized by rapid tumor progression with a median survival of 2 to 4 months.

• #31 Clinical manifestations of lung cancer – UpToDatePresenting_symptoms_lung_ca.htm

  https://www.uptodate.com/contents/clinical-manifestations-of-lung-cancer/print

  During the course of their disease, approximately 10 to 15 percent of patients who have lung cancer will have a malignant pleural effusion. […] The staging at presentation of patients with known or suspected lung cancer is reviewed elsewhere. […] The most frequent sites of distant metastasis are the liver, adrenal glands, bones, and brain. […] Metastasis from lung cancer to bone is frequently symptomatic. Pain in the back, chest, or extremity and elevated levels of serum alkaline phosphatase are usually present in patients who have bone metastasis. […] In patients with NSCLC, the frequency of brain metastasis is greatest with adenocarcinoma and least with squamous cell carcinoma. […] In patients with SCLC, metastasis to brain is present in approximately 20 to 30 percent of patients at presentation.

• #32 How Does Lung Cancer Progress? Timeline & What To Expect – O2 Healthcare Group

  https://o2healthcaregroup.com/news-and-articles/how-does-lung-cancer-progress-timeline-what-to-expect/

  Brain metastases, often known as “brain mets,” develop when cancer cells in the lung break away and enter the bloodstream, eventually reaching the brain. Those who have lung cancer will frequently experience this. Up to 50% of patients have a lifetime risk of having the problem, and about 25% will have a brain met at the time of diagnosis.

• #33 Stage 4 Lung Cancer: Metastatic Symptoms, Treatment, Survival

  https://www.cancercenter.com/cancer-types/lung-cancer/stages/stage-iv-lung-cancer

  Lung cancer becomes more serious and difficult to treat as it progresses. Advanced or metastatic lung cancers of any kind tend to have very low survival rates. […] Patients with metastatic (stage 4) non-small cell lung cancer thats spread to distant organs or regions of the body have a five-year relative survival rate of 8 percent, according to ACS. Stage 4 non-small cell lung cancer that has spread regionally has a five-year relative survival rate of 37 percent. […] For metastatic (stage 4) small cell lung cancer thats widespread in the body, the five-year relative survival rate is 3 percent. For patients with stage 4 small cell lung cancer that has spread regionally, the five-year relative survival rate is 18 percent.

• #34 Lung Cancer Stages, Prognosis, and Progression

  https://www.verywellhealth.com/lung-cancer-progression-5221706

  Physical changes in end-stage lung cancer include fluid build-up around the lungs, shortness of breath, consistent cough, obstruction and/or bleeding of the airways, fatigue, weight loss and pain. […] Lung cancer is most responsive to treatment when detected and treated early. Its important to remember that your life expectancy may be different than someone else with the same type and stage of cancer. […] Treatments such as chemotherapy, radiation, and surgery may stop the progression of lung cancer. Targeted therapies used to prevent tumors from growing can slow the progression of lung cancer. […] Getting a diagnosis at an early stage before cancer has metastasized to other areas of the body can have a positive impact on your prognosis, as can early palliative care.

• #35 Asymptomatic Lung Cancer: Can You Be Diagnosed With No Symptoms? | MyLungCancerTeam

  https://www.mylungcancerteam.com/resources/asymptomatic-lung-cancer-can-you-be-diagnosed-with-no-symptoms

  Lung cancer treatment is most likely to be effective in the early stages. […] Because lung cancer doesnt always cause symptoms in the early stages, lung cancer screenings are key for early detection. […] Although screening can allow for early detection of lung cancer, it doesnt always mean lung cancer will be found early, and it may not find all types of lung cancer.

• #36 Asymptomatic Lung Cancer: Can You Be Diagnosed With No Symptoms? | MyLungCancerTeam

  https://www.mylungcancerteam.com/resources/asymptomatic-lung-cancer-can-you-be-diagnosed-with-no-symptoms

  A lack of symptoms in the early stages is believed to be one of the reasons why lung cancer is often only diagnosed in more advanced stages. […] Symptoms of lung cancer include: A cough that doesnt go away or gets worse as time goes on, Wheezing or shortness of breath, Chest pain, Coughing up blood, Unexplained weight loss, Constant tiredness. […] One study found that the following symptoms were more common in people with early-stage lung cancer versus late-stage lung cancer: Cough, Shortness of breath, Wheezing or chest crackles. […] A persistent cough or pneumonia that keeps coming back may be one of the early symptoms of lung cancer. […] One study found that the time between the first recorded symptoms of lung cancer and diagnosis was 570 days (about a year and a half), on average.

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