Materiały źródłowe

• #1 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Progressive supranuclear palsy is a rare brain disease that affects walking, balance, eye movements and swallowing. The disease results from the damage of cells in areas of the brain that control body movement, coordination, thinking and other important functions. […] Progressive supranuclear palsy worsens over time and can lead to dangerous complications, such as pneumonia and trouble swallowing. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the symptoms. […] Symptoms of progressive supranuclear palsy include: A loss of balance while walking. A tendency to fall backward can occur very early in the disease. […] An inability to aim your eyes properly. People with progressive supranuclear palsy may not be able to look downward. Or they may experience blurring and double vision. Not being able to focus the eyes can make some people spill food. They also may appear disinterested in conversation because of lack of eye contact.

• #2

  https://www.psp.org/iwanttolearn/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is an adult-onset, neurological disease that impacts movement, thinking, speech and vision. PSP is commonly referred to as an atypical parkinsonism because of its overlap of certain symptoms with Parkinsons disease. However, it often progresses quite differently than Parkinsons disease, and it shares similar pathology to Alzheimers and frontotemporal dementia. […] On average, symptoms begin in the early 60s, but may start as early as in the 40s. […] PSP is considered rare, affecting 6-10 individuals per 100,000, with about 30,000 cases in the United States. […] PSP is sometimes called an atypical parkinsonism because of its overlap with some Parkinsons disease symptoms. However, PSP and Parkinson’s have their own unique set of symptoms and disease progression because they have different underlying causes. PSP symptoms are more similar to those associated with Alzheimer’s disease and frontotemporal dementia. […] More than 50% of people with PSP are initially misdiagnosed with Parkinsons disease. […] PSP also progresses more quickly than Parkinson’s disease. […] The name of the disease includes the word progressive because, unfortunately, early symptoms get worse and new symptoms develop over time.

• #3 Progressive Supranuclear Palsy: 4 Stages, Symptoms & Care | Plexus

  https://plexusnc.com/progressive-supranuclear-palsy-stages-treatment/

  Progressive Supranuclear Palsy (PSP) is a rare yet life-altering neurological disorder that affects movement, balance, vision, and thinking. Often confused with Parkinsons disease in its early stages, PSP is a distinct condition with unique symptoms and a faster rate of progression. […] Symptoms of PSP tend to develop gradually, starting subtly and becoming more disabling over time. Early signs may include difficulty with balance, unexpected falls (often backwards), personality or mood changes, and trouble moving the eyes especially looking up or down. […] As the disease progresses, muscle stiffness, slurred speech, trouble swallowing, memory lapses, and slowed thinking may emerge. Some individuals may also experience emotional shifts like inappropriate laughter or crying signs of the brains deeper involvement.

• #4 Progressive supranuclear palsy | Monash Health

  https://monashhealth.org/services/movement-disorders-program/understanding-movement-disorders/progressive-supranuclear-palsy/

  Progressive supranuclear palsy (PSP) is a rare and progressive neurodegenerative disorder. […] PSP can affect eye movements, walking, balance, speech, swallowing, mood, behaviour and thought processes (cognition). […] PSP symptoms most commonly occur in the persons 60s, with slightly more men than women affected. The minimum age of onset for diagnostic purposes is currently set at 40. […] Some of the PSP symptoms are similar to those of Parkinsons disease (PD), especially in the early stages of PSP. […] PSP differs to PD in that it progresses faster and the symptoms are more severe. […] The onset of the symptoms, their progression and severity can vary greatly between people. […] PSP results in a wide range of symptoms, which include: stiffness or rigidity, slow movements, walking difficulties, falls, difficulty moving the eyes, mood and behavioural changes, thinking or cognitive problems, speech and swallowing difficulties, postural problems due to dystonia.

• #5 What is Progressive Supranuclear Palsy (PSP)?

  http://www.psp-australia.org.au/whatis-psp.html

  Progressive Supranuclear Palsy is a rare neurological condition affecting parts of the brain that control walking, eye movements, balance, speech and swallowing. Symptoms usually begin between the ages of 60 and 70. […] PSP has a wide range of symptoms, but few people experience them all and symptoms vary from person to person. It is a progressive condition, meaning that the symptoms tend to worsen over time. However, the severity and rate of symptom progression varies widely. […] Symptoms can include: Problems with walking (or gait). These may include stiffness, problems with balance and unexplained falls, particularly backwards. A feeling of dizziness. Slow movements. Facial stiffness. Problems with eyesight or vision. Problems with thinking or changes in personality. Slurring of speech. Mild shaking of hands. […] People with PSP are at risk of developing serious complications such as pneumonia, choking, head injury and fractures. As the condition progresses, these complications can cause death.

• #6

  https://www.psp.org/iwanttolearn/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is an adult-onset, neurological disease that impacts movement, thinking, speech and vision. PSP is commonly referred to as an atypical parkinsonism because of its overlap of certain symptoms with Parkinsons disease. However, it often progresses quite differently than Parkinsons disease, and it shares similar pathology to Alzheimers and frontotemporal dementia. […] On average, symptoms begin in the early 60s, but may start as early as in the 40s. […] PSP is considered rare, affecting 6-10 individuals per 100,000, with about 30,000 cases in the United States. […] PSP is sometimes called an atypical parkinsonism because of its overlap with some Parkinsons disease symptoms. However, PSP and Parkinson’s have their own unique set of symptoms and disease progression because they have different underlying causes. PSP symptoms are more similar to those associated with Alzheimer’s disease and frontotemporal dementia. […] More than 50% of people with PSP are initially misdiagnosed with Parkinsons disease. […] PSP also progresses more quickly than Parkinson’s disease. […] The name of the disease includes the word progressive because, unfortunately, early symptoms get worse and new symptoms develop over time.

• #7 Progressive Supranuclear Palsy Symptoms | Progressive Supranuclear Palsy | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/progressive-supranuclear-palsy/progressive-supranuclear-palsy-symptoms/

  The early symptoms of progressive supranuclear palsy (PSP) are often attributed to the aging process. In many cases, after a few months, it becomes increasingly apparent that the changes are not part of normal aging. […] Early symptoms can include subtle changes in speech, mood, cognition, and behavior. For example, a person can become apathetic or seem slow to comprehend new information. In addition, early symptoms include: Slowing of movement, Stiffness in the muscles of the neck and limbs, Unsteadiness and loss of balance, leading to falls, Vision problems, such as blurriness, dry eyes, or difficulty focusing and following. […] The disease affects different people differently. Function declines over the course of five to 10 years, but the rate of change and the symptoms can vary. As the disease progresses, patients might experience: Confusion, Decreased skill in hand function, Dementia, Depression, Heightened emotions (laughing or crying at minor stimuli), Impaired speech and swallowing, Postural instability leading to recurrent falls, especially backward falls when changing direction, Slower movements. […] In very advanced PSP, maintaining proper nutrition becomes more difficult, and declining lung clearance is common in the final stages of illness.

• #8 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Progressive supranuclear palsy is a rare brain disease that affects walking, balance, eye movements and swallowing. The disease results from the damage of cells in areas of the brain that control body movement, coordination, thinking and other important functions. […] Progressive supranuclear palsy worsens over time and can lead to dangerous complications, such as pneumonia and trouble swallowing. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the symptoms. […] Symptoms of progressive supranuclear palsy include: A loss of balance while walking. A tendency to fall backward can occur very early in the disease. […] An inability to aim your eyes properly. People with progressive supranuclear palsy may not be able to look downward. Or they may experience blurring and double vision. Not being able to focus the eyes can make some people spill food. They also may appear disinterested in conversation because of lack of eye contact.

• #9

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #10

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #11 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  Progressive supranuclear palsy (PSP) is a rare neurological disorder that affects body movements, walking and balance, and eye movements. PSP typically begins in a persons mid- to late-60s, later than when Parkinsons disease symptoms typically develop. The disease usually worsens rapidly and most people with PSP develop severe disability within three to five years of symptom onset. PSP can lead to serious complications such as pneumonia, choking, or head injuries from falls. […] PSP affects a persons movements, and can lead to loss of balance, difficulty walking or swallowing, slurred speech, problems with eye movements. The most frequent first symptom of PSP is a loss of balance while walking which can lead to abrupt and unexplained falls. People with PSP may also have stiffness and slow movement.

• #12

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #13

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #14

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #15

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #16

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #17

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/

  Progressive supranuclear palsy (PSP) is a rare neurological condition that can cause problems with balance, movement, vision, speech and swallowing. […] The symptoms of PSP usually get gradually worse over time. […] Some of the main symptoms of PSP include: problems with balance and mobility, including frequent falls, changes in behaviour, such as irritability or apathy (lack of interest), muscle stiffness, an inability to control eye and eyelid movement, including focusing on specific objects or looking up or down at something, slow, quiet or slurred speech, difficulty swallowing (dysphagia), slowness of thought and some memory problems. […] The rate at which the symptoms progress can vary widely from person to person. […] There’s currently nothing that can be done to stop PSP gradually worsening, although research into new treatments gives hope that this may be possible in the future.

• #18

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  Progressive Supranuclear Palsy (PSP) is characterized by progressive problems with balance, movement, vision, speech, and swallowing. […] The progression of PSP can be divided into three main stages: early, middle, and late. It is important to note that the symptoms and progression of PSP can vary greatly among individuals, and not everyone will experience the same symptoms or timeline. […] During the early stage of PSP, symptoms are generally mild and may be difficult to distinguish from other neurological disorders or age-related changes. Common early symptoms include: Balance and Gait Disturbances: Individuals may experience unsteadiness and frequent falls, often occurring when walking or changing positions. Falls are typically backward, and individuals may have difficulty recovering their balance.

• #19

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  Progressive Supranuclear Palsy (PSP) is characterized by progressive problems with balance, movement, vision, speech, and swallowing. […] The progression of PSP can be divided into three main stages: early, middle, and late. It is important to note that the symptoms and progression of PSP can vary greatly among individuals, and not everyone will experience the same symptoms or timeline. […] During the early stage of PSP, symptoms are generally mild and may be difficult to distinguish from other neurological disorders or age-related changes. Common early symptoms include: Balance and Gait Disturbances: Individuals may experience unsteadiness and frequent falls, often occurring when walking or changing positions. Falls are typically backward, and individuals may have difficulty recovering their balance.

• #20 Progressive Supranuclear Palsy Symptoms | Progressive Supranuclear Palsy | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/progressive-supranuclear-palsy/progressive-supranuclear-palsy-symptoms/

  The early symptoms of progressive supranuclear palsy (PSP) are often attributed to the aging process. In many cases, after a few months, it becomes increasingly apparent that the changes are not part of normal aging. […] Early symptoms can include subtle changes in speech, mood, cognition, and behavior. For example, a person can become apathetic or seem slow to comprehend new information. In addition, early symptoms include: Slowing of movement, Stiffness in the muscles of the neck and limbs, Unsteadiness and loss of balance, leading to falls, Vision problems, such as blurriness, dry eyes, or difficulty focusing and following. […] The disease affects different people differently. Function declines over the course of five to 10 years, but the rate of change and the symptoms can vary. As the disease progresses, patients might experience: Confusion, Decreased skill in hand function, Dementia, Depression, Heightened emotions (laughing or crying at minor stimuli), Impaired speech and swallowing, Postural instability leading to recurrent falls, especially backward falls when changing direction, Slower movements. […] In very advanced PSP, maintaining proper nutrition becomes more difficult, and declining lung clearance is common in the final stages of illness.

• #21 Progressive Supranuclear Palsy Symptoms | Progressive Supranuclear Palsy | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/progressive-supranuclear-palsy/progressive-supranuclear-palsy-symptoms/

  The early symptoms of progressive supranuclear palsy (PSP) are often attributed to the aging process. In many cases, after a few months, it becomes increasingly apparent that the changes are not part of normal aging. […] Early symptoms can include subtle changes in speech, mood, cognition, and behavior. For example, a person can become apathetic or seem slow to comprehend new information. In addition, early symptoms include: Slowing of movement, Stiffness in the muscles of the neck and limbs, Unsteadiness and loss of balance, leading to falls, Vision problems, such as blurriness, dry eyes, or difficulty focusing and following. […] The disease affects different people differently. Function declines over the course of five to 10 years, but the rate of change and the symptoms can vary. As the disease progresses, patients might experience: Confusion, Decreased skill in hand function, Dementia, Depression, Heightened emotions (laughing or crying at minor stimuli), Impaired speech and swallowing, Postural instability leading to recurrent falls, especially backward falls when changing direction, Slower movements. […] In very advanced PSP, maintaining proper nutrition becomes more difficult, and declining lung clearance is common in the final stages of illness.

• #22

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #23

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Early symptoms may include subtle changes in balance, gait instability, difficulties with eye movements and cognitive changes such as mild executive dysfunction. Some individuals may experience changes in mood or behavior during this stage. As the disease progresses into later stages, symptoms become more pronounced and impact daily functioning. Gait and balance problems worsen, leading to an increased risk of falls.

• #24

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  As the disease progresses to the middle stage, symptoms become more pronounced and can significantly impact an individual’s daily functioning. Common middle stage symptoms include: Increased Gait and Balance Problems: Balance and gait disturbances become more severe, leading to frequent falls and an increased risk of injury. […] In the late stage of PSP, individuals may become severely disabled and require assistance with most daily activities. Common late-stage symptoms include: Severe Mobility Limitations: At this stage, individuals may be unable to walk or stand independently and may require a wheelchair or other mobility aids. […] Progressive Supranuclear Palsy is a complex and challenging disease that can significantly impact the lives of those affected. Understanding the stages and symptoms of PSP is crucial for early diagnosis, appropriate management, and the ability to plan for future care needs.

• #25

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  As the disease progresses to the middle stage, symptoms become more pronounced and can significantly impact an individual’s daily functioning. Common middle stage symptoms include: Increased Gait and Balance Problems: Balance and gait disturbances become more severe, leading to frequent falls and an increased risk of injury. […] In the late stage of PSP, individuals may become severely disabled and require assistance with most daily activities. Common late-stage symptoms include: Severe Mobility Limitations: At this stage, individuals may be unable to walk or stand independently and may require a wheelchair or other mobility aids. […] Progressive Supranuclear Palsy is a complex and challenging disease that can significantly impact the lives of those affected. Understanding the stages and symptoms of PSP is crucial for early diagnosis, appropriate management, and the ability to plan for future care needs.

• #26

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Symptoms of progressive supranuclear palsy (PSP) can affect the neck, ability to swallow, eye coordination and speech. […] As progressive supranuclear palsy moves into the middle and late stages, symptoms often mimic those of other diseases such as Parkinsons disease, dementia and multiple system atrophy (MSA). Later stage symptoms of PSP might include: Stiffness, particularly in the neck and clumsy movements, Increased frequency of falling, particularly backward, Speech slowness or slurring, Difficulty swallowing, potentially leading to gagging or choking, Sensitivity to bright light, Sleep disturbances, Decreased interest in previously enjoyable activities, Impulsive behavior, unexplained laughter or crying, Impaired reasoning, problem-solving and decision-making abilities, Onset of depression and anxiety, A fixed or startled facial expression due to rigid facial muscles, Feelings of dizziness.

• #27

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Symptoms of progressive supranuclear palsy (PSP) can affect the neck, ability to swallow, eye coordination and speech. […] As progressive supranuclear palsy moves into the middle and late stages, symptoms often mimic those of other diseases such as Parkinsons disease, dementia and multiple system atrophy (MSA). Later stage symptoms of PSP might include: Stiffness, particularly in the neck and clumsy movements, Increased frequency of falling, particularly backward, Speech slowness or slurring, Difficulty swallowing, potentially leading to gagging or choking, Sensitivity to bright light, Sleep disturbances, Decreased interest in previously enjoyable activities, Impulsive behavior, unexplained laughter or crying, Impaired reasoning, problem-solving and decision-making abilities, Onset of depression and anxiety, A fixed or startled facial expression due to rigid facial muscles, Feelings of dizziness.

• #28

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #29

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Symptoms of progressive supranuclear palsy (PSP) can affect the neck, ability to swallow, eye coordination and speech. […] As progressive supranuclear palsy moves into the middle and late stages, symptoms often mimic those of other diseases such as Parkinsons disease, dementia and multiple system atrophy (MSA). Later stage symptoms of PSP might include: Stiffness, particularly in the neck and clumsy movements, Increased frequency of falling, particularly backward, Speech slowness or slurring, Difficulty swallowing, potentially leading to gagging or choking, Sensitivity to bright light, Sleep disturbances, Decreased interest in previously enjoyable activities, Impulsive behavior, unexplained laughter or crying, Impaired reasoning, problem-solving and decision-making abilities, Onset of depression and anxiety, A fixed or startled facial expression due to rigid facial muscles, Feelings of dizziness.

• #30

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #31

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #32

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #33

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #34

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #35

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #36

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  As the disease progresses to the middle stage, symptoms become more pronounced and can significantly impact an individual’s daily functioning. Common middle stage symptoms include: Increased Gait and Balance Problems: Balance and gait disturbances become more severe, leading to frequent falls and an increased risk of injury. […] In the late stage of PSP, individuals may become severely disabled and require assistance with most daily activities. Common late-stage symptoms include: Severe Mobility Limitations: At this stage, individuals may be unable to walk or stand independently and may require a wheelchair or other mobility aids. […] Progressive Supranuclear Palsy is a complex and challenging disease that can significantly impact the lives of those affected. Understanding the stages and symptoms of PSP is crucial for early diagnosis, appropriate management, and the ability to plan for future care needs.

• #37

  https://pspawareness.com/blogs/psp-q-a/progressive-supranuclear-palsy-stages-symptoms-and-navigating-the-journey?srsltid=AfmBOorR4jUYxYx7m-SZPuX9E9Fc5SkvpvHlIedqbLaaJ5sPLGaUztKH

  As the disease progresses to the middle stage, symptoms become more pronounced and can significantly impact an individual’s daily functioning. Common middle stage symptoms include: Increased Gait and Balance Problems: Balance and gait disturbances become more severe, leading to frequent falls and an increased risk of injury. […] In the late stage of PSP, individuals may become severely disabled and require assistance with most daily activities. Common late-stage symptoms include: Severe Mobility Limitations: At this stage, individuals may be unable to walk or stand independently and may require a wheelchair or other mobility aids. […] Progressive Supranuclear Palsy is a complex and challenging disease that can significantly impact the lives of those affected. Understanding the stages and symptoms of PSP is crucial for early diagnosis, appropriate management, and the ability to plan for future care needs.

• #38

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #39

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #40

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #41

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #42

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #43

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #44

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #45

  https://pspawareness.com/blogs/psp-q-a/what-are-the-stages-for-psp-how-many?srsltid=AfmBOoo6QSPOX0uhGD-5XiMOrTKRJYeGZPlwKDrdhVJZ0lVx-riHK72E

  In the advanced stage of PSP, individuals may become wheelchair-bound and require assistance with daily activities such as eating, dressing, and bathing. Symptoms such as rigidity, spasticity, and involuntary movements become more severe. […] In the end-of-life stage of PSP, individuals may be bedridden and require around-the-clock care. They may have difficulty swallowing, become more susceptible to infections, and experience other complications related to the progression of the disease. […] It’s important to note that not everyone with PSP will experience all of these stages, and the progression of the disease can vary widely from person to person. Additionally, some individuals may experience rapid progression, while others may experience a slower course of the disease.

• #46

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #47

  https://www.advocatehealth.com/health-services/brain-spine-institute/brain-care-center/conditions-treatments/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that impacts various motor functions such as walking, balance, swallowing and eye movements. Its a progressive disease that stems from cell damage in specific brain areas responsible for controlling movement, coordination and thinking. […] PSP typically has four stages to characterize how far along the disease has progressed. Each stage has its own unique symptoms. These stages include: Early stage: Symptoms may look like normal signs of aging, such as trouble walking or vision problems. Some people develop anxiety and decreased desire to interact with others. Mid-stage: At this stage, you may need walking aids and vision problems may worsen. Trouble swallowing and speaking are also common. Advanced stage: Motor abilities worsen in this stage. You may require a wheelchair and will become more dependent on others for most or all care. Vision and speech are significantly impaired as well. The risks for inhaling food (aspiration) and developing pneumonia are very high. End of life: You may likely not be able to eat or drink on your own. The risk of falling, major fracture or an infection is high.

• #48

  https://pspawareness.com/blogs/psp-q-a/what-are-the-stages-for-psp-how-many?srsltid=AfmBOoo6QSPOX0uhGD-5XiMOrTKRJYeGZPlwKDrdhVJZ0lVx-riHK72E

  In the advanced stage of PSP, individuals may become wheelchair-bound and require assistance with daily activities such as eating, dressing, and bathing. Symptoms such as rigidity, spasticity, and involuntary movements become more severe. […] In the end-of-life stage of PSP, individuals may be bedridden and require around-the-clock care. They may have difficulty swallowing, become more susceptible to infections, and experience other complications related to the progression of the disease. […] It’s important to note that not everyone with PSP will experience all of these stages, and the progression of the disease can vary widely from person to person. Additionally, some individuals may experience rapid progression, while others may experience a slower course of the disease.

• #49 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare condition that affects certain areas of your brain. Common symptoms include balance issues with frequent falls, eye movement issues and cognitive changes. There isnt a cure for PSP, but certain treatments can help manage symptoms. […] The symptoms of progressive supranuclear palsy vary from person to person. They tend to begin gradually and typically become more severe over years. […] The most common first signs of PSP include: A loss of balance when walking or climbing stairs. This often involves falling, especially falling backward. Difficulty looking downward with your eyes. A wide-eyed staring expression. […] Other symptoms of PSP include: Difficulty swallowing. Stiff muscles that affect mobility (your ability to move). Difficulty speaking. Your speech might be quieter and slurred, making it hard to pronounce words. Mood changes, such as depression, apathy (loss of interest) and irritability. Personality changes. Changes in behavior, such as impulsivity and poor judgment. Dementia. Insomnia. REM sleep behavior disorder (RBD). Sensitivity to bright light (photophobia).

• #50 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Progressive supranuclear palsy is a rare brain disease that affects walking, balance, eye movements and swallowing. The disease results from the damage of cells in areas of the brain that control body movement, coordination, thinking and other important functions. […] Progressive supranuclear palsy worsens over time and can lead to dangerous complications, such as pneumonia and trouble swallowing. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the symptoms. […] Symptoms of progressive supranuclear palsy include: A loss of balance while walking. A tendency to fall backward can occur very early in the disease. […] An inability to aim your eyes properly. People with progressive supranuclear palsy may not be able to look downward. Or they may experience blurring and double vision. Not being able to focus the eyes can make some people spill food. They also may appear disinterested in conversation because of lack of eye contact.

• #51 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  Progressive supranuclear palsy (PSP) is a rare neurological disorder that affects body movements, walking and balance, and eye movements. PSP typically begins in a persons mid- to late-60s, later than when Parkinsons disease symptoms typically develop. The disease usually worsens rapidly and most people with PSP develop severe disability within three to five years of symptom onset. PSP can lead to serious complications such as pneumonia, choking, or head injuries from falls. […] PSP affects a persons movements, and can lead to loss of balance, difficulty walking or swallowing, slurred speech, problems with eye movements. The most frequent first symptom of PSP is a loss of balance while walking which can lead to abrupt and unexplained falls. People with PSP may also have stiffness and slow movement.

• #52

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #53 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  Progressive supranuclear palsy (PSP) is a rare brain disorder that affects approximately 6 in 100,000 people worldwide. It causes muscle weakness and affects gait, balance and overall movement, as well as the patients mood, cognitive skills and behavior. […] Identifying the distinctive symptoms of PSP is crucial when making the right diagnosis, as a number of symptoms overlap with those of Parkinsons disease and other neurodegenerative disorders. […] PSP results in weakness of the muscles (palsy) and affects the patients ability to walk, maintain balance, and commonly leads to falling or bumping into objects. Unlike typical Parkinson disease, falls begin within the first year of PSP and are common by year three. This is one of the main indicators used in making a differential diagnosis.

• #54 Progressive Supranuclear Palsy

  https://neurosciences.ucsd.edu/centers-programs/movement-disorders/community/disease-overview/psp.html

  Symptoms of PSP vary depending on the areas of the brain that are affected by the disease. Accordingly, there are variable clinical syndromes (presentations) of the disease. […] This syndrome is the most common form of PSP that typically starts above age 50 with balance disturbances that lead to unexplained falls, often backward without loss of consciousness. Patients may develop gait instability with broad-based steps. Slowness (bradykinesia) and stiffness (rigidity) are Parkinsonian symptoms that occur in all disorders that mimick Parkinson’s disease. […] Slowness in daily activities is another feature of PSP. For example, PSP patients often take longer to eat, dress, and bathe. Those with Richardson syndrome tend to walk, turn and sit as a „block” because of stiffness in their trunk. They also usually develop slowness and stiffness more in their neck and trunk than in their limbs.

• #55

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #56 Signs & Symptoms for Progressive Supranuclear Palsy | PSP help

  https://www.pspassociation.org.uk/information-and-support/what-is-psp/signs-symptoms-psp/

  Difficulties in movement and balance are a common feature of PSP. Frequent falls which are often backwards. Movements may be very slow and your muscles may become stiff. […] As people become increasingly immobile as PSP progresses constipation, lack of bowel control and urinary problems may develop. […] Eating, drinking and swallowing difficulties are common in PSP and can occur fairly soon after diagnosis. Coughing when eating or drinking is an indication that food or drink has gone down the wrong way into the airway. If this occurs regularly, it can lead to chest infections or pneumonia. […] People living with PSP may experience visual problems which cant be corrected by glasses. […] In PSP, areas of the brain controlling the movement of the tongue, lips and throat can impact on speech making it slurred and difficult to understand. […] Many people living with PSP experience fatigue. This is an overwhelming feeling of tiredness, lack of energy and exhaustion.

• #57 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Additional symptoms of progressive supranuclear palsy vary and may mimic those of Parkinson’s disease and dementia. Symptoms get worse over time and may include: Stiffness, especially of the neck, and awkward movements. Falling, especially falling backward. Slow or slurred speech. Trouble swallowing, which may cause gagging or choking. Being sensitive to bright light. Trouble with sleep. Loss of interest in pleasurable activities. Impulsive behavior, or laughing or crying for no reason. Trouble with reasoning, problem-solving and decision-making. Depression and anxiety. A surprised or frightened facial expression, resulting from rigid facial muscles. Dizziness. […] Make an appointment with your healthcare professional if you experience any of the symptoms listed above.

• #58 PSP – Progressive Supranuclear Palsy / Brain Injury by degenerative diseases / Types of brain injury – brain disorders | Braininjury-explanation.com

  https://www.braininjury-explanation.com/types-of-brain-injury-brain-disorders/brain-injury-by-detoriating-processes/psp-progressive-supranuclear-paresis

  Difficulty swallowing. Difficulty eating. Dementia with apathy, lack of initiative, depression and anxiety. Logical thinking gets poorer; not so much in understanding, but performing thinking and doing sometimes gets disturbed early in the disease. […] Unsteady gait and often fall backward. The falling is not caused by stumbling, but it is due to being less attentive to respond to postural changes. Impaired eye movement; a limited field of vision; no longer be able to look up or down without moving the head and starting to see poorer (vision palsy and ophthalmoplegia). Stiffness, in particular of neck muscles and long back muscles. This creates an unusual posture completely upright, with uplifted head. […] A characteristic of PSP is shrivelling (atrophy) in the upper part of the brain stem (mesencephalon). The timely provision of the correct diagnosis, even though the disease cannot be cured, gives the patient and family members the opportunity to learn to deal with the condition. PSP is often confused with Parkinson’s disease or dementia.

• #59 Signs & Symptoms for Progressive Supranuclear Palsy | PSP help

  https://www.pspassociation.org.uk/information-and-support/what-is-psp/signs-symptoms-psp/

  Difficulties in movement and balance are a common feature of PSP. Frequent falls which are often backwards. Movements may be very slow and your muscles may become stiff. […] As people become increasingly immobile as PSP progresses constipation, lack of bowel control and urinary problems may develop. […] Eating, drinking and swallowing difficulties are common in PSP and can occur fairly soon after diagnosis. Coughing when eating or drinking is an indication that food or drink has gone down the wrong way into the airway. If this occurs regularly, it can lead to chest infections or pneumonia. […] People living with PSP may experience visual problems which cant be corrected by glasses. […] In PSP, areas of the brain controlling the movement of the tongue, lips and throat can impact on speech making it slurred and difficult to understand. […] Many people living with PSP experience fatigue. This is an overwhelming feeling of tiredness, lack of energy and exhaustion.

• #60 Signs & Symptoms for Progressive Supranuclear Palsy | PSP help

  https://www.pspassociation.org.uk/information-and-support/what-is-psp/signs-symptoms-psp/

  Difficulties in movement and balance are a common feature of PSP. Frequent falls which are often backwards. Movements may be very slow and your muscles may become stiff. […] As people become increasingly immobile as PSP progresses constipation, lack of bowel control and urinary problems may develop. […] Eating, drinking and swallowing difficulties are common in PSP and can occur fairly soon after diagnosis. Coughing when eating or drinking is an indication that food or drink has gone down the wrong way into the airway. If this occurs regularly, it can lead to chest infections or pneumonia. […] People living with PSP may experience visual problems which cant be corrected by glasses. […] In PSP, areas of the brain controlling the movement of the tongue, lips and throat can impact on speech making it slurred and difficult to understand. […] Many people living with PSP experience fatigue. This is an overwhelming feeling of tiredness, lack of energy and exhaustion.

• #61 PSP – Progressive Supranuclear Palsy / Brain Injury by degenerative diseases / Types of brain injury – brain disorders | Braininjury-explanation.com

  https://www.braininjury-explanation.com/types-of-brain-injury-brain-disorders/brain-injury-by-detoriating-processes/psp-progressive-supranuclear-paresis

  Difficulty swallowing. Difficulty eating. Dementia with apathy, lack of initiative, depression and anxiety. Logical thinking gets poorer; not so much in understanding, but performing thinking and doing sometimes gets disturbed early in the disease. […] Unsteady gait and often fall backward. The falling is not caused by stumbling, but it is due to being less attentive to respond to postural changes. Impaired eye movement; a limited field of vision; no longer be able to look up or down without moving the head and starting to see poorer (vision palsy and ophthalmoplegia). Stiffness, in particular of neck muscles and long back muscles. This creates an unusual posture completely upright, with uplifted head. […] A characteristic of PSP is shrivelling (atrophy) in the upper part of the brain stem (mesencephalon). The timely provision of the correct diagnosis, even though the disease cannot be cured, gives the patient and family members the opportunity to learn to deal with the condition. PSP is often confused with Parkinson’s disease or dementia.

• #62 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #63

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  People with progressive supranuclear palsy (PSP) develop a range of difficulties with balance, movement, vision, speech and swallowing. […] The symptoms typically become more severe over several years, although the speed at which they worsen varies. […] The initial symptoms of PSP can include: sudden loss of balance when walking that usually results in repeated falls, often backwards; muscle stiffness, particularly in the neck; extreme tiredness; changes in personality, such as irritability, apathy (lack of interest) and mood swings; changes in behaviour, such as recklessness and poor judgement; a dislike of bright lights (photophobia); difficulty controlling the eye muscles (particularly problems with looking up and down); blurred or double vision. […] Over time, the initial symptoms of PSP will become more severe.

• #64 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  Often one of the first symptoms noted during a physical examination is the slow vertical movement of the eyes. Patients will complain of having difficulty reading, as their ability to gaze downwards and upwards (vertical saccades) is affected. Typically, downgaze palsy is experienced first, followed by upgaze palsy. […] Blurring of vision is common as the extraocular muscle response slows over time. Eventually, gaze palsy may be present in all directions, leading to a loss of all eye movement. […] Sometimes the eyelids do not open properly, and this may lead to the need to turn the head in different directions if one has to look there, as well as drooping eyelids, and too little blinking. […] Patients with PSP whose eyesight is affected, along with eyeball and eyelid movements, may seem to be not looking at the speaker, and/or may be unable to hold the speakers gaze during a conversation. Their facial expression may mimic surprise or astonishment as well.

• #65 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #66 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #67 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #68 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  Patients most commonly fall backwards, as their reflexes are affected. It is typical for the patients to lunge forward when starting to move leading to frequent falls. Difficulty with walking and maintaining balance worsens over time, including slow movement (bradykinesia) and clumsiness. […] Muscle stiffness is also commonly experienced by patients suffering from PSP, resulting in the loss of fluidity of movement and often affecting the persons sleep patterns. […] Dysphagia, or poor swallowing, also manifests itself in the course of the disease. This can lead to difficulty with feeding resulting in malnutrition. […] The motor neurons that control the extraocular muscles are affected in the course of the disease. This results in blurring of vision as one of the more distinct symptoms of the condition, an important factor in the diagnosis.

• #69 Progressive Supranuclear Palsy

  https://neurosciences.ucsd.edu/centers-programs/movement-disorders/community/disease-overview/psp.html

  Most of the important symptoms of PSP that lead to its name are found in the eye movements. Vertical supranuclear gaze paresis is a movement limitation of the eyes that results in the inability to aim the eyes properly looking up and down, with the ocular reflexes preserved. […] Light sensitivity (photophobia) is another symptom related of PSP that can be explained in part by a decrease in eye blinking. It can be associated with redness of the eyes and increased tearing and patients may need to wear sunglasses even indoors to avoid the irritating light. Due to the severely decreased blinking and diminished facial expressions (mask face), PSP patients may have an „astonished” or „surprise” face. […] Patients with PSP-RS usually have some degree of apathy (loss of interest) and slowness of thought (bradyphrenia) associated with impaired attention. Other symptoms related to mental dysfunction are forgetfulness, difficulty in making decisions, impaired abstract thought, and occasionally disinhibition (executive dysfunction). […] Dysarthria (poor articulation of speech) and dysphagia (swallowing) are also frequently affected relatively early in the course of the disease. The disease progresses relatively slowly, but PSP-RS patients have a shortened survival rate than in the general population.

• #70 Progressive supranuclear palsy | Monash Health

  https://monashhealth.org/services/movement-disorders-program/understanding-movement-disorders/progressive-supranuclear-palsy/

  The most common symptoms in the early stages are unsteadiness and loss of balance when walking plus changes in thinking or behaviour and non-specific blurred vision. […] As PSP progresses, most people with this disorder go on to develop all of the above symptoms. Symptoms tend to progress rapidly and unexplained falls increase in frequency and walking becomes more unsteady. […] Moving the eyes becomes a more obvious problem as PSP progresses. […] Speech and swallowing difficulties are common in PSP and usually present early. These problems are more severe and progress more rapidly than in PD. […] Changes in cognition (memory and thinking) and mood are more common in the early stages of PSP and are more severe in PSP compared to PD. […] The most common mood changes are depression, apathy, and irritability. […] Fatigue affects many people with PSP causing overwhelming tiredness, lack of energy and exhaustion. […] Pain is very common with PSP.

• #71

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/

  Progressive supranuclear palsy (PSP) is a rare neurological condition that can cause problems with balance, movement, vision, speech and swallowing. […] The symptoms of PSP usually get gradually worse over time. […] Some of the main symptoms of PSP include: problems with balance and mobility, including frequent falls, changes in behaviour, such as irritability or apathy (lack of interest), muscle stiffness, an inability to control eye and eyelid movement, including focusing on specific objects or looking up or down at something, slow, quiet or slurred speech, difficulty swallowing (dysphagia), slowness of thought and some memory problems. […] The rate at which the symptoms progress can vary widely from person to person. […] There’s currently nothing that can be done to stop PSP gradually worsening, although research into new treatments gives hope that this may be possible in the future.

• #72 Progressive Supranuclear Palsy | Memory and Aging Center

  https://memory.ucsf.edu/es/node/7611

  Dysarthria (slow or slurred speech) is a very common symptom in PSP. People with PSP often find it difficult to converse with others because of their delayed responses and difficulties with speech pronunciation. Eventually, swallowing food, and particularly liquids, can be poorly coordinated, leading to the leakage of food into the windpipe (dysphagia). This can result in pneumonia, the most common cause of death in PSP. Some warning signs caregivers should look for are drooling, food collecting in the mouth, increased effort in swallowing, chest congestion, trouble talking and weight loss. […] PSP patients also experience cognitive and behavioral changes consistent with a decline in frontal lobe functioning, such as slow information processing and retrieval, concrete thinking, impaired reasoning, difficulty planning and shifting between tasks. Behaviorally, patients often exhibit apathy, including decreased motivation and withdrawal, impulsivity and perseveration, an inability to switch tasks or change topic. Depression is also common.

• #73 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Additional symptoms of progressive supranuclear palsy vary and may mimic those of Parkinson’s disease and dementia. Symptoms get worse over time and may include: Stiffness, especially of the neck, and awkward movements. Falling, especially falling backward. Slow or slurred speech. Trouble swallowing, which may cause gagging or choking. Being sensitive to bright light. Trouble with sleep. Loss of interest in pleasurable activities. Impulsive behavior, or laughing or crying for no reason. Trouble with reasoning, problem-solving and decision-making. Depression and anxiety. A surprised or frightened facial expression, resulting from rigid facial muscles. Dizziness. […] Make an appointment with your healthcare professional if you experience any of the symptoms listed above.

• #74 Progressive supranuclear palsy (PSP) | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/progressive-supranuclear-palsy-psp/

  The symptoms of PSP, like balance and mobility problems, are likely to progressively get worse. […] As the symptoms of PSP get worse, your speech might become slower and more slurred. […] Mobility problems might get worse and you might need a wheelchair to help you get around. […] At the advanced stage, people with PSP are likely to have difficulty controlling the muscles of their mouth, tongue and throat. […] Swallowing problems can become worse because of the loss of control of the throat muscles. […] PSP can cause problems like constipation and difficulty passing urine (peeing). It can also cause frequent peeing during the night. Sometimes it can cause you to lose control of your bowel and bladder movements (incontinence).

• #75 Signs & Symptoms for Progressive Supranuclear Palsy | PSP help

  https://www.pspassociation.org.uk/information-and-support/what-is-psp/signs-symptoms-psp/

  Difficulties in movement and balance are a common feature of PSP. Frequent falls which are often backwards. Movements may be very slow and your muscles may become stiff. […] As people become increasingly immobile as PSP progresses constipation, lack of bowel control and urinary problems may develop. […] Eating, drinking and swallowing difficulties are common in PSP and can occur fairly soon after diagnosis. Coughing when eating or drinking is an indication that food or drink has gone down the wrong way into the airway. If this occurs regularly, it can lead to chest infections or pneumonia. […] People living with PSP may experience visual problems which cant be corrected by glasses. […] In PSP, areas of the brain controlling the movement of the tongue, lips and throat can impact on speech making it slurred and difficult to understand. […] Many people living with PSP experience fatigue. This is an overwhelming feeling of tiredness, lack of energy and exhaustion.

• #76

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Speech may become increasingly slow and slurred, making it harder to understand. […] There may also be some problems with thinking, concentration and memory (dementia), although these are generally mild and the person will normally retain an awareness of themselves. […] The loss of control of the throat muscles can lead to severe swallowing problems. […] Many people with PSP also develop problems with their bowels and bladder functions. […] Constipation and difficulty passing urine are common, as is the need to pass urine several times during the night. […] Some people may lose control over their bladder or bowel movements (incontinence).

• #77 Progressive Supranuclear Palsy (PSP): Life Expectancy, Signs, Causes, Treatment

  https://www.medicinenet.com/progressive_supranuclear_palsy/article.htm

  Most patients with PSP display the characteristic findings of slowness of movement, stiffness, balance difficulty, and eye movement problems. […] Generally, the cognitive and behavioral symptoms are mild and less severe than in other types of dementia, such as Alzheimer’s disease and stroke-related dementia. These symptoms are more likely to occur in the later stages of the disease. […] PSP is a progressive disease that may leave you vulnerable to a number of life-threatening complications. […] People with PSP usually need a walking aid, such as a cane or walker, within 3-4 years of the first symptoms of the disease. […] The typical lifespan from the first appearance of symptoms is about 6-10 years. The main causes of death are infections and breathing problems.

• #78 Progressive Supranuclear Palsy

  https://neurosciences.ucsd.edu/centers-programs/movement-disorders/community/disease-overview/psp.html

  Most of the important symptoms of PSP that lead to its name are found in the eye movements. Vertical supranuclear gaze paresis is a movement limitation of the eyes that results in the inability to aim the eyes properly looking up and down, with the ocular reflexes preserved. […] Light sensitivity (photophobia) is another symptom related of PSP that can be explained in part by a decrease in eye blinking. It can be associated with redness of the eyes and increased tearing and patients may need to wear sunglasses even indoors to avoid the irritating light. Due to the severely decreased blinking and diminished facial expressions (mask face), PSP patients may have an „astonished” or „surprise” face. […] Patients with PSP-RS usually have some degree of apathy (loss of interest) and slowness of thought (bradyphrenia) associated with impaired attention. Other symptoms related to mental dysfunction are forgetfulness, difficulty in making decisions, impaired abstract thought, and occasionally disinhibition (executive dysfunction). […] Dysarthria (poor articulation of speech) and dysphagia (swallowing) are also frequently affected relatively early in the course of the disease. The disease progresses relatively slowly, but PSP-RS patients have a shortened survival rate than in the general population.

• #79 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #80 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #81 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #82 Progressive Supranuclear Palsy | Memory and Aging Center

  https://memory.ucsf.edu/es/node/7611

  Dysarthria (slow or slurred speech) is a very common symptom in PSP. People with PSP often find it difficult to converse with others because of their delayed responses and difficulties with speech pronunciation. Eventually, swallowing food, and particularly liquids, can be poorly coordinated, leading to the leakage of food into the windpipe (dysphagia). This can result in pneumonia, the most common cause of death in PSP. Some warning signs caregivers should look for are drooling, food collecting in the mouth, increased effort in swallowing, chest congestion, trouble talking and weight loss. […] PSP patients also experience cognitive and behavioral changes consistent with a decline in frontal lobe functioning, such as slow information processing and retrieval, concrete thinking, impaired reasoning, difficulty planning and shifting between tasks. Behaviorally, patients often exhibit apathy, including decreased motivation and withdrawal, impulsivity and perseveration, an inability to switch tasks or change topic. Depression is also common.

• #83 Progressive Supranuclear Palsy | AFTD

  https://www.theaftd.org/what-is-ftd/progressive-supranuclear-palsy/

  Slurred or slowed speech due to difficulty moving the muscles controlling the lips, tongue and jaw. […] A progressive deterioration in the diagnosed person’s ability to control or adjust their behavior appropriately in different social contexts is the hallmark of the behavior changes, and results in the embarrassing, inappropriate social situations that can be one of the most disturbing facets of FTD and related disorders. […] PSP patients may suffer increasing impairment in “executive functions,” such as distractibility, mental rigidity and inflexibility, impairments in planning and problem solving, and poor financial judgment. PSP patients may also have memory problems. They also develop progressive language disturbance. […] Based on overlapping symptoms, PSP is frequently misdiagnosed as Parkinson’s or another movement disorder. Some symptoms – especially the potential behavioral and cognitive ones – may appear later in the progression of the disease. If you have concern that you or a loved one may have been misdiagnosed – or about any of the signs and symptoms listed above – it is important to consult a doctor.

• #84 Progressive Supranuclear Palsy | Memory and Aging Center

  https://memory.ucsf.edu/es/node/7611

  While balance and walking problems are usually early features of the disease, the illness can present with cognitive and behavioral changes. Visual and oculomotor problems tend to appear early as well. […] Later in the disease, people with PSP may feel increasing weakness in their limbs. Their balance may get worse, and they may fall more often while walking. Eye problems, such as keeping eye contact with another person, will get worse. PSP can also affect a person’s ability to speak, and their voice may become soft and weak. Mood and behavior changes may occur. People with PSP may become irritable, forgetful, or depressed, and they may become less interested in things. They may also become more impulsive in their decision-making. […] PSP is a disease that changes with time. A person with PSP can live many years with the disease. Research suggests that a person with PSP may live an average of seven years with the disease, although this can vary from person to person.

• #85 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #86 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #87 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #88 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #89 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #90 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #91 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #92 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  As the disease progresses, most people develop eye problems. Eye and vision symptoms may include slow eye movements, trouble looking up or down, trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, and tendency to move the head rather than just the eyes to look in different directions. […] People with PSP and their loved ones may notice changes in mood or behavior. These may include depression, lack of motivation, changes in judgment, insight, and problem solving, difficulty finding words, forgetfulness, loss of interest in activities the person used to enjoy, increased irritability, sudden laughing, crying, or angry outbursts for no apparent reason, personality changes, slowed, slurred, or monotone speech, difficulty swallowing, mask-like facial expressions, and sleep problems.

• #93 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #94 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #95

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Worsening balance and mobility problems may mean that walking becomes impossible and a wheelchair is needed. […] Controlling the eye muscles will become more difficult, increasing the risk of falls and making everyday tasks, such as reading and eating, more problematic. […] New symptoms can also develop at this stage, such as: slow, quiet or slurred speech; problems swallowing (dysphagia); reduced blinking reflex, which can cause the eyes to dry out and become irritated; involuntary blinking or twitching of the eyelids, which can last from several seconds to hours; disturbed sleep; slowness of thought and some memory problems; neck, back and joint pain and headaches. […] As PSP progresses to an advanced stage, people with the condition normally begin to experience increasing difficulties controlling the muscles of their mouth, throat and tongue.

• #96 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  PSP exhibits itself in a number of behavioral and cognitive changes as well, as some areas of the brain located in the frontal lobe are affected. […] Patients experience difficulties with memory, reasoning, problem-solving and decision-making and may lose interest in activities which they have previously found pleasurable. […] Typical cognitive changes include: slowness, difficulty focusing attention, difficulty switching between tasks, forgetfulness. […] Some of the cognitive symptoms include: apathy, disinhibition, dysphoria, anxiety. […] Some patients report compulsive-obsessive symptoms. This often leads to patients trying to perform motor tasks that they are not able to do, for example, to get up and walk on their own. This can lead to falls. […] Sleep disturbances and sensitivity to light are common among patients with PSP. Muscle stiffness is an added factor which makes the patients uncomfortable and hinders sleep. They typically experience early or late insomnia and difficulties in maintaining sleep.

• #97 Signs & Symptoms for Progressive Supranuclear Palsy | PSP help

  https://www.pspassociation.org.uk/information-and-support/what-is-psp/signs-symptoms-psp/

  Difficulties in movement and balance are a common feature of PSP. Frequent falls which are often backwards. Movements may be very slow and your muscles may become stiff. […] As people become increasingly immobile as PSP progresses constipation, lack of bowel control and urinary problems may develop. […] Eating, drinking and swallowing difficulties are common in PSP and can occur fairly soon after diagnosis. Coughing when eating or drinking is an indication that food or drink has gone down the wrong way into the airway. If this occurs regularly, it can lead to chest infections or pneumonia. […] People living with PSP may experience visual problems which cant be corrected by glasses. […] In PSP, areas of the brain controlling the movement of the tongue, lips and throat can impact on speech making it slurred and difficult to understand. […] Many people living with PSP experience fatigue. This is an overwhelming feeling of tiredness, lack of energy and exhaustion.

• #98 Progressive supranuclear palsy | Monash Health

  https://monashhealth.org/services/movement-disorders-program/understanding-movement-disorders/progressive-supranuclear-palsy/

  The most common symptoms in the early stages are unsteadiness and loss of balance when walking plus changes in thinking or behaviour and non-specific blurred vision. […] As PSP progresses, most people with this disorder go on to develop all of the above symptoms. Symptoms tend to progress rapidly and unexplained falls increase in frequency and walking becomes more unsteady. […] Moving the eyes becomes a more obvious problem as PSP progresses. […] Speech and swallowing difficulties are common in PSP and usually present early. These problems are more severe and progress more rapidly than in PD. […] Changes in cognition (memory and thinking) and mood are more common in the early stages of PSP and are more severe in PSP compared to PD. […] The most common mood changes are depression, apathy, and irritability. […] Fatigue affects many people with PSP causing overwhelming tiredness, lack of energy and exhaustion. […] Pain is very common with PSP.

• #99

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Speech may become increasingly slow and slurred, making it harder to understand. […] There may also be some problems with thinking, concentration and memory (dementia), although these are generally mild and the person will normally retain an awareness of themselves. […] The loss of control of the throat muscles can lead to severe swallowing problems. […] Many people with PSP also develop problems with their bowels and bladder functions. […] Constipation and difficulty passing urine are common, as is the need to pass urine several times during the night. […] Some people may lose control over their bladder or bowel movements (incontinence).

• #100

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Speech may become increasingly slow and slurred, making it harder to understand. […] There may also be some problems with thinking, concentration and memory (dementia), although these are generally mild and the person will normally retain an awareness of themselves. […] The loss of control of the throat muscles can lead to severe swallowing problems. […] Many people with PSP also develop problems with their bowels and bladder functions. […] Constipation and difficulty passing urine are common, as is the need to pass urine several times during the night. […] Some people may lose control over their bladder or bowel movements (incontinence).

• #101

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/symptoms/

  Speech may become increasingly slow and slurred, making it harder to understand. […] There may also be some problems with thinking, concentration and memory (dementia), although these are generally mild and the person will normally retain an awareness of themselves. […] The loss of control of the throat muscles can lead to severe swallowing problems. […] Many people with PSP also develop problems with their bowels and bladder functions. […] Constipation and difficulty passing urine are common, as is the need to pass urine several times during the night. […] Some people may lose control over their bladder or bowel movements (incontinence).

• #102 Progressive supranuclear palsy | Monash Health

  https://monashhealth.org/services/movement-disorders-program/understanding-movement-disorders/progressive-supranuclear-palsy/

  The most common symptoms in the early stages are unsteadiness and loss of balance when walking plus changes in thinking or behaviour and non-specific blurred vision. […] As PSP progresses, most people with this disorder go on to develop all of the above symptoms. Symptoms tend to progress rapidly and unexplained falls increase in frequency and walking becomes more unsteady. […] Moving the eyes becomes a more obvious problem as PSP progresses. […] Speech and swallowing difficulties are common in PSP and usually present early. These problems are more severe and progress more rapidly than in PD. […] Changes in cognition (memory and thinking) and mood are more common in the early stages of PSP and are more severe in PSP compared to PD. […] The most common mood changes are depression, apathy, and irritability. […] Fatigue affects many people with PSP causing overwhelming tiredness, lack of energy and exhaustion. […] Pain is very common with PSP.

• #103 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Progressive supranuclear palsy is a rare brain disease that affects walking, balance, eye movements and swallowing. The disease results from the damage of cells in areas of the brain that control body movement, coordination, thinking and other important functions. […] Progressive supranuclear palsy worsens over time and can lead to dangerous complications, such as pneumonia and trouble swallowing. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the symptoms. […] Symptoms of progressive supranuclear palsy include: A loss of balance while walking. A tendency to fall backward can occur very early in the disease. […] An inability to aim your eyes properly. People with progressive supranuclear palsy may not be able to look downward. Or they may experience blurring and double vision. Not being able to focus the eyes can make some people spill food. They also may appear disinterested in conversation because of lack of eye contact.

• #104 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #105 Progressive Supranuclear Palsy | AFTD

  https://www.theaftd.org/what-is-ftd/progressive-supranuclear-palsy/

  There is currently no effective treatment for PSP. In some patients, the slowness, stiffness, and balance problems of PSP may respond to anti-parkinsonian agents such as levodopa, or levodopa combined with anticholinergic agents, but the effect is usually temporary. […] PSP predisposes those affected to serious complications such as pneumonia followed from difficulty in swallowing (dysphagia). The most common complications are choking and pneumonia, head injury, and fractures caused by falls. A surgical procedure involving a gastrostomy tube may be done when there are significant and severe swallowing disturbances. This surgery involves the placement of a tube through the skin of the abdomen into the stomach for feeding purposes. […] The most common cause of death is pneumonia. With good attention to medical and nutritional needs, however, most PSP patients live well into their 70s and beyond.

• #106 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #107 Progressive Supranuclear Palsy | AFTD

  https://www.theaftd.org/what-is-ftd/progressive-supranuclear-palsy/

  There is currently no effective treatment for PSP. In some patients, the slowness, stiffness, and balance problems of PSP may respond to anti-parkinsonian agents such as levodopa, or levodopa combined with anticholinergic agents, but the effect is usually temporary. […] PSP predisposes those affected to serious complications such as pneumonia followed from difficulty in swallowing (dysphagia). The most common complications are choking and pneumonia, head injury, and fractures caused by falls. A surgical procedure involving a gastrostomy tube may be done when there are significant and severe swallowing disturbances. This surgery involves the placement of a tube through the skin of the abdomen into the stomach for feeding purposes. […] The most common cause of death is pneumonia. With good attention to medical and nutritional needs, however, most PSP patients live well into their 70s and beyond.

• #108 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Progressive-Supranuclear-Palsy-Symptoms.aspx

  Patients most commonly fall backwards, as their reflexes are affected. It is typical for the patients to lunge forward when starting to move leading to frequent falls. Difficulty with walking and maintaining balance worsens over time, including slow movement (bradykinesia) and clumsiness. […] Muscle stiffness is also commonly experienced by patients suffering from PSP, resulting in the loss of fluidity of movement and often affecting the persons sleep patterns. […] Dysphagia, or poor swallowing, also manifests itself in the course of the disease. This can lead to difficulty with feeding resulting in malnutrition. […] The motor neurons that control the extraocular muscles are affected in the course of the disease. This results in blurring of vision as one of the more distinct symptoms of the condition, an important factor in the diagnosis.

• #109 Progressive Supranuclear Palsy Symptoms | Progressive Supranuclear Palsy | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/progressive-supranuclear-palsy/progressive-supranuclear-palsy-symptoms/

  The early symptoms of progressive supranuclear palsy (PSP) are often attributed to the aging process. In many cases, after a few months, it becomes increasingly apparent that the changes are not part of normal aging. […] Early symptoms can include subtle changes in speech, mood, cognition, and behavior. For example, a person can become apathetic or seem slow to comprehend new information. In addition, early symptoms include: Slowing of movement, Stiffness in the muscles of the neck and limbs, Unsteadiness and loss of balance, leading to falls, Vision problems, such as blurriness, dry eyes, or difficulty focusing and following. […] The disease affects different people differently. Function declines over the course of five to 10 years, but the rate of change and the symptoms can vary. As the disease progresses, patients might experience: Confusion, Decreased skill in hand function, Dementia, Depression, Heightened emotions (laughing or crying at minor stimuli), Impaired speech and swallowing, Postural instability leading to recurrent falls, especially backward falls when changing direction, Slower movements. […] In very advanced PSP, maintaining proper nutrition becomes more difficult, and declining lung clearance is common in the final stages of illness.

• #110 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #111 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #112 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #113 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #114 Progressive Supranuclear Palsy: Understanding This Rare Condition

  https://www.healthline.com/health/progressive-supranuclear-palsy

  Progressive supranuclear palsy is a quickly progressing condition. Most people with the condition have severe symptoms within 3 to 5 years. Life expectancies can vary. Its possible for people with progressive supranuclear palsy to live over a decade after initial diagnosis. […] However, the average life expectancy is about 6 to 9 years after initial diagnosis. Factors such as stage at diagnosis influence life expectancy. […] Progressive supranuclear palsy progresses very quickly. It often leads to death less than 10 years after the first symptoms appear. […] The condition progresses quickly, with a standard life expectancy of less than a decade after the first symptoms appear.

• #115 Progressive Supranuclear Palsy (PSP) – Brain Foundation

  https://brainfoundation.org.au/disorders/progressive-supranuclear-palsy/

  Some of the characteristic signs and symptoms of PSP include impaired balance and mobility, including early falls; cognitive changes such as apathy, impulsivity, depression or anxiety; blurry or double vision; trouble controlling eye and facial movements; difficulty swallowing; muscle stiffness and loss of ability to move certain muscles; distorted, slow, or slurred speech; urinary urgency, incontinence, or constipation; sleep difficulties; change in food preferences; weight loss; drooling; and problems with thinking and memory. […] PSP gets progressively worse but is not itself directly life-threatening. It does, however, predispose patients to serious complications such as pneumonia secondary to difficulty in swallowing. The average prognosis after diagnosis sits between 5-9 years. The most common complications are choking and pneumonia, head injury and fractures caused by falls. The most common cause of death is pneumonia. […] With good attention to medical and nutritional needs, however, most PSP patients live well into their 70s and beyond.

• #116 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #117 Progressive Supranuclear Palsy | AFTD

  https://www.theaftd.org/what-is-ftd/progressive-supranuclear-palsy/

  There is currently no effective treatment for PSP. In some patients, the slowness, stiffness, and balance problems of PSP may respond to anti-parkinsonian agents such as levodopa, or levodopa combined with anticholinergic agents, but the effect is usually temporary. […] PSP predisposes those affected to serious complications such as pneumonia followed from difficulty in swallowing (dysphagia). The most common complications are choking and pneumonia, head injury, and fractures caused by falls. A surgical procedure involving a gastrostomy tube may be done when there are significant and severe swallowing disturbances. This surgery involves the placement of a tube through the skin of the abdomen into the stomach for feeding purposes. […] The most common cause of death is pneumonia. With good attention to medical and nutritional needs, however, most PSP patients live well into their 70s and beyond.

• #118 Progressive Supranuclear Palsy (PSP): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/6096-progressive-supranuclear-palsy

  The prognosis (outlook) for progressive supranuclear palsy (PSP) is generally poor. The symptoms worsen with time, and there currently isnt treatment that can reverse or stop PSP. However, the sooner you receive a diagnosis and start a treatment plan, the better your quality of life will be. […] Most people with PSP eventually need a wheelchair. You may need part- or full-time care as early as three to four years into living with PSP. But this varies from person to person. […] Over time, PSP complications can be fatal. […] People with progressive supranuclear palsy typically die six to nine years after their diagnosis. But this can vary. […] PSP symptoms increase your risk of developing pneumonia, which can be fatal. Aspiration pneumonia is the most common cause of death in people with PSP. It happens when the muscles in your throat become weak and uncoordinated and food and liquids accidentally trickle down your windpipe and into your lungs. […] People with PSP also have a higher risk of falls, which can result in bone fractures and head traumas. Falls that cause serious injuries are a common cause of death among people with PSP.

• #119 Progressive Supranuclear Palsy (PSP): Life Expectancy, Signs, Causes, Treatment

  https://www.medicinenet.com/progressive_supranuclear_palsy/article.htm

  Most patients with PSP display the characteristic findings of slowness of movement, stiffness, balance difficulty, and eye movement problems. […] Generally, the cognitive and behavioral symptoms are mild and less severe than in other types of dementia, such as Alzheimer’s disease and stroke-related dementia. These symptoms are more likely to occur in the later stages of the disease. […] PSP is a progressive disease that may leave you vulnerable to a number of life-threatening complications. […] People with PSP usually need a walking aid, such as a cane or walker, within 3-4 years of the first symptoms of the disease. […] The typical lifespan from the first appearance of symptoms is about 6-10 years. The main causes of death are infections and breathing problems.

• #120

  https://www.psp.org/iwanttolearn/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is an adult-onset, neurological disease that impacts movement, thinking, speech and vision. PSP is commonly referred to as an atypical parkinsonism because of its overlap of certain symptoms with Parkinsons disease. However, it often progresses quite differently than Parkinsons disease, and it shares similar pathology to Alzheimers and frontotemporal dementia. […] On average, symptoms begin in the early 60s, but may start as early as in the 40s. […] PSP is considered rare, affecting 6-10 individuals per 100,000, with about 30,000 cases in the United States. […] PSP is sometimes called an atypical parkinsonism because of its overlap with some Parkinsons disease symptoms. However, PSP and Parkinson’s have their own unique set of symptoms and disease progression because they have different underlying causes. PSP symptoms are more similar to those associated with Alzheimer’s disease and frontotemporal dementia. […] More than 50% of people with PSP are initially misdiagnosed with Parkinsons disease. […] PSP also progresses more quickly than Parkinson’s disease. […] The name of the disease includes the word progressive because, unfortunately, early symptoms get worse and new symptoms develop over time.

• #121 Progressive Supranuclear Palsy: 4 Stages, Symptoms & Care | Plexus

  https://plexusnc.com/progressive-supranuclear-palsy-stages-treatment/

  PSP progresses faster, affects eye movement more severely, and impacts cognitive abilities earlier than Parkinsons. It also typically responds poorly to medications used for Parkinsons. […] The average progression spans 5 to 10 years after the first symptoms appear. Some people decline faster than others, depending on the severity and subtype of PSP. […] Life expectancy typically ranges from 6 to 10 years post-diagnosis. However, supportive care, fall prevention, and symptom management can greatly improve quality of life.

• #122

  https://www.psp.org/iwanttolearn/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is an adult-onset, neurological disease that impacts movement, thinking, speech and vision. PSP is commonly referred to as an atypical parkinsonism because of its overlap of certain symptoms with Parkinsons disease. However, it often progresses quite differently than Parkinsons disease, and it shares similar pathology to Alzheimers and frontotemporal dementia. […] On average, symptoms begin in the early 60s, but may start as early as in the 40s. […] PSP is considered rare, affecting 6-10 individuals per 100,000, with about 30,000 cases in the United States. […] PSP is sometimes called an atypical parkinsonism because of its overlap with some Parkinsons disease symptoms. However, PSP and Parkinson’s have their own unique set of symptoms and disease progression because they have different underlying causes. PSP symptoms are more similar to those associated with Alzheimer’s disease and frontotemporal dementia. […] More than 50% of people with PSP are initially misdiagnosed with Parkinsons disease. […] PSP also progresses more quickly than Parkinson’s disease. […] The name of the disease includes the word progressive because, unfortunately, early symptoms get worse and new symptoms develop over time.

• #123 Progressive supranuclear palsy & Parkinson’s disease | APDA

  https://www.apdaparkinson.org/article/progressive-supranuclear-palsy-corticobasal-degeneration/

  PSP and CBD can mimic each other and can also mimic PD early in the clinical course, so it can be confusing and difficult to diagnose. […] The most recent consensus classifies PSP into several clinical subtypes. However, the following four primary clinical signs are key features in a majority of cases, although they may not be present all at once in every patient: Eye movement abnormalities, Unprovoked falls, Parkinsonism, Behavioral, speech and cognitive problems early in the course. […] The progression of PSP is typically more rapid than PD, leading to dysphagia (difficulty in swallowing), falls causing injury, and immobility much earlier in the course than in PD.

• #124 Progressive Supranuclear Palsy: 4 Stages, Symptoms & Care | Plexus

  https://plexusnc.com/progressive-supranuclear-palsy-stages-treatment/

  PSP progresses faster, affects eye movement more severely, and impacts cognitive abilities earlier than Parkinsons. It also typically responds poorly to medications used for Parkinsons. […] The average progression spans 5 to 10 years after the first symptoms appear. Some people decline faster than others, depending on the severity and subtype of PSP. […] Life expectancy typically ranges from 6 to 10 years post-diagnosis. However, supportive care, fall prevention, and symptom management can greatly improve quality of life.

• #125 Progressive Supranuclear Palsy Clinical Presentation: History, Physical Examination, Complications

  https://emedicine.medscape.com/article/1151430-clinical

  Although presentations vary and early predominance of a particular symptom is not unusual, over time, a wider spectrum of symptoms inevitably ensues. Several other features have been reported, including sleep disturbance with insomnia, clumsiness, impaired handwriting, and oscillopsia. […] The early appearance of gait and balance dysfunction in PSP may be contrasted with the course of idiopathic Parkinson disease, in which imbalance tends to occur late in the disease. […] Cognitive dysfunction and personality change are common in patients with PSP, but they are generally milder in degree than those seen in patients with primary dementing illnesses such as Alzheimer disease. Slowed cognitive processing, sequencing and planning difficulties, mild memory difficulty, and apathy are typical. These are generally more prominent later in the course of the disease.

• #126 Corticobasal Degeneration and Progressive Supranuclear Palsy | Northwestern Medicine

  https://www.nm.org/conditions-and-care-areas/neurosciences/other-dementia-disorders/corticobasal-degeneration-and-progressive-supranuclear-palsy

  In addition to these symptoms, people with PSP also develop problems moving their eyes, called supranuclear palsy, a wide-eyed appearance, and difficulty swallowing. Unlike Parkinson Disease, people often fall backward instead of forward. They may also develop severe stiffness in the neck. […] All the symptoms of PSP and CBD get worse as the diseases progress. Eventually, people may become completely bedbound and unable to safely walk. Swallowing problems may lead to choking on food or getting food in the lungs, leading to pneumonia. On average, people with these diseases die within 5 years of diagnosis. Death is usually from complications of falls or swallowing problems.

• #127 Progressive supranuclear palsy | Handouts | MedLink Neurology

  https://www.medlink.com/handouts/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is a rare neurological disorder that affects body movements, walking and balance, and eye movements. Progressive supranuclear palsy typically begins in a persons mid- to late-60s, later than when Parkinson disease symptoms typically develop. The disease usually worsens rapidly and most people with progressive supranuclear palsy develop severe disability within three to five years of symptom onset. Progressive supranuclear palsy affects a persons movements, and can lead to loss of balance, difficulty walking or swallowing, slurred speech, problems with eye movements. The most frequent first symptom of progressive supranuclear palsy is a loss of balance while walking which can lead to abrupt and unexplained falls. As the disease progresses, most people develop eye problems. Eye and vision symptoms may include: Slow eye movements, Trouble looking up or down, Trouble controlling eyelids, involuntary closing of the eyes, decreased blinking, or difficulty opening the eyes, Tendency to move the head rather than just the eyes to look in different directions. People with progressive supranuclear palsy and their loved ones may notice changes in mood or behavior. These may include: Depression, Lack of motivation, Changes in judgment, insight, and problem-solving, Difficulty finding words, Forgetfulness, Loss of interest in activities the person used to enjoy, Increased irritability, Sudden laughing, crying, or angry outbursts for no apparent reason, Personality changes, Slowed, slurred, or monotone speech, Difficulty swallowing, Mask-like facial expressions, Sleep problems. The two disorders share many symptoms; however, progressive supranuclear palsy progresses more rapidly than Parkinson disease. Problems with speech and swallowing are much more common and severe in progressive supranuclear palsy than in Parkinson disease and usually show up earlier in the disease. There is currently no treatment that effectively stops or slows the progression of progressive supranuclear palsy, and symptoms usually do not respond well to medications.

• #128 Progressive Supranuclear Palsy: 4 Stages, Symptoms & Care | Plexus

  https://plexusnc.com/progressive-supranuclear-palsy-stages-treatment/

  PSP progresses faster, affects eye movement more severely, and impacts cognitive abilities earlier than Parkinsons. It also typically responds poorly to medications used for Parkinsons. […] The average progression spans 5 to 10 years after the first symptoms appear. Some people decline faster than others, depending on the severity and subtype of PSP. […] Life expectancy typically ranges from 6 to 10 years post-diagnosis. However, supportive care, fall prevention, and symptom management can greatly improve quality of life.

• #129 Progressive Supranuclear Palsy: 4 Stages, Symptoms & Care | Plexus

  https://plexusnc.com/progressive-supranuclear-palsy-stages-treatment/

  PSP progresses faster, affects eye movement more severely, and impacts cognitive abilities earlier than Parkinsons. It also typically responds poorly to medications used for Parkinsons. […] The average progression spans 5 to 10 years after the first symptoms appear. Some people decline faster than others, depending on the severity and subtype of PSP. […] Life expectancy typically ranges from 6 to 10 years post-diagnosis. However, supportive care, fall prevention, and symptom management can greatly improve quality of life.

• #130 Progressive Supranuclear Palsy (PSP) | ParkinsonsDisease.netShare to Facebookprint pageBookmark for latercommentcaret iconcaret iconmore actionsmore actionsFollow us on facebookFollow us on facebookFollow us on linkedincaret icon

  https://parkinsonsdisease.net/clinical/progressive-supranuclear-palsy

  Progressive supranuclear palsy (PSP) is not Parkinson’s disease (PD), but is a Parkinsonian-like syndrome. PSP is a rare brain disorder that causes serious and progressive problems with gait and balance, as well as eye movement and thinking problems. […] PSP affects balance, movement, gait, vision, speech, thinking, mood and behavior displays. PSP symptoms that are similar to those of PD include difficulties with balance, unexplained falls, and awkward gait. […] A classic early sign of PSP is visual disturbance – the inability to control the movement of the eyes. Changes in vision and control of the eyes can be diagnostic clues that differentiate PSP. […] Cognitive symptoms including changes in executive function, mood and behavior are also common in PSP. There can be losses of emotional stability characterized by sudden and uncontrollable bouts of laughter or crying which can result in embarrassing and inappropriate behavior in social or work situations. […] There is neither a cure nor an effective treatment for PSP. Most symptoms don’t respond to drug therapy. Some anti-parkinsonian medications like levodopa have been tried but therapeutic effects, if any, are generally short-lived.

• #131 Progressive supranuclear palsy – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/symptoms-causes/syc-20355659

  Progressive supranuclear palsy is a rare brain disease that affects walking, balance, eye movements and swallowing. The disease results from the damage of cells in areas of the brain that control body movement, coordination, thinking and other important functions. […] Progressive supranuclear palsy worsens over time and can lead to dangerous complications, such as pneumonia and trouble swallowing. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the symptoms. […] Symptoms of progressive supranuclear palsy include: A loss of balance while walking. A tendency to fall backward can occur very early in the disease. […] An inability to aim your eyes properly. People with progressive supranuclear palsy may not be able to look downward. Or they may experience blurring and double vision. Not being able to focus the eyes can make some people spill food. They also may appear disinterested in conversation because of lack of eye contact.

• #132

  https://www.nhs.uk/conditions/progressive-supranuclear-palsy-psp/

  Progressive supranuclear palsy (PSP) is a rare neurological condition that can cause problems with balance, movement, vision, speech and swallowing. […] The symptoms of PSP usually get gradually worse over time. […] Some of the main symptoms of PSP include: problems with balance and mobility, including frequent falls, changes in behaviour, such as irritability or apathy (lack of interest), muscle stiffness, an inability to control eye and eyelid movement, including focusing on specific objects or looking up or down at something, slow, quiet or slurred speech, difficulty swallowing (dysphagia), slowness of thought and some memory problems. […] The rate at which the symptoms progress can vary widely from person to person. […] There’s currently nothing that can be done to stop PSP gradually worsening, although research into new treatments gives hope that this may be possible in the future.

• #133 Progressive Supranuclear Palsy (PSP) | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp

  Currently there are no tests or brain imaging techniques to definitively diagnose PSP. A physician will review your medical history and perform a physical and neurological exam. It is important to identify problems with gait, eye movements, speech, and swallowing early. […] There is currently no treatment that effectively stops or slows the progression of PSP, and symptoms usually do not respond well to medications.

• #134 About Progressive Supranuclear Palsy (PSP) | PSP & CBD Foundation

  https://pspcbdfoundation.org/about-progressive-supra-nuclear-palsy-psp/

  Progressive Supra-nuclear Palsy (PSP) is a brain disease that affects approximately 3 to 6 people out of 100,000 worldwide and there is approximately 20,000 people living with PSP in the United States. Understanding symptoms and signs of PSP help identify disease progression, differentiate between other neurological diseases, and improve quality of life by addressing individual symptoms. […] PSP Symptoms include: Lack of balance resulting in falls, Slurred or increased pace of speech, Vision issues that may include difficulty looking up and down, double vision, tunnel vision, difficulty controlling eye lids, prolonged or infrequent blinking, difficulty closing eye lids, and difficulty maintaining eye contact, Changes in mood and behavior to include difficulty showing apathy, irritability, and symptoms of depression, Cognitive changes may occur to include difficulty with judgement, insight, forgetfulness, and problem solving, Flat affect/monotone/lack of facial expressions, Slow movement, Dysphagia (swallowing difficulty/disorder). […] There is currently no effective treatment or cure for PSP, however management of individual symptoms is utilized to improve patient’s quality of life.

• #135 Progressive supranuclear palsy – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/diagnosis-treatment/drc-20355664

  Progressive supranuclear palsy can be hard to diagnose because symptoms are similar to those of Parkinson’s disease. […] You may need an MRI to learn if you have shrinkage in specific regions of the brain associated with progressive supranuclear palsy. […] Although there is no cure for progressive supranuclear palsy, treatments are available to help ease symptoms of the disorder. […] Researchers are working to develop treatments of progressive supranuclear palsy, including therapies that may block the formation of tau or help to destroy tau. […] Progressive supranuclear palsy can cause changes in your brain that make you feel anxious or laugh or cry for no reason. Progressive supranuclear palsy also can become frustrating as walking, talking and eating become harder. […] How does progressive supranuclear palsy usually progress?

• #136 New Hope for Progressive Supranuclear Palsy with Innovative Trial | UC San Francisco

  https://www.ucsf.edu/news/2024/09/428366/new-hope-progressive-supranuclear-palsy-innovative-trial

  A clinical trial that will test three drugs concurrently, and could include more, represents new hope for patients with progressive supranuclear palsy (PSP), an incurable neurodegenerative disorder that usually kills within seven years after symptoms start. […] There are currently no drugs to stall the diseases deadly progression. […] PSP is believed to be triggered by a buildup of tau protein that causes brain cells to weaken and die. It is frequently mistaken for Parkinsons disease. Both conditions are movement disorders, but PSP is far less common, affecting approximately 30,000 Americans, most of whom are in their fifties to seventies. […] Richardsons syndrome is the most common form of PSP. In addition to cognitive difficulties, symptoms include slowness, stiffness, falling backward and difficulty with eye movement, especially looking down. […] Even if we slow the progression of the disease by 20%, 30%, thats a meaningful impact on a condition with relentless progression and no cure.

Zobacz więcej