Materiały źródłowe

• #1 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Well, I think it’s important to recognize what the goals of treatment are. Low-grade lymphomas have an advantage in that they can take a very long time to cause any symptoms, and certainly a very long time to put the patient’s health at risk. However, we do not have a curative treatment that will fix the cancer right away. So we want to weigh up the potential risks and side effects that come with treatment compared to, clearly, the risks and side effects that come from the cancer. So, if you have a cancer that is very low-grade, growing very slowly, giving you no symptoms, we would hold off on treatment and only initiate it when you truly need it. […] Many types of treatments exist for lymphoma. Treatments include radiation, chemotherapy, immunotherapy, targeted therapy and bone marrow transplant, also called stem cell transplant. Sometimes, a combination of treatments is used. The treatment that’s best for you will depend on the kind of lymphoma that you have.

• #2 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Blood cancers, including lymphoma, are extremely heterogeneous and can involve a variety of treatment options, often in combination. Some form of chemotherapy, radiation therapy, immunotherapy, or a combination is typically used to treat Hodgkin lymphoma. Bone marrow or stem cell transplantation may also sometimes be done under special circumstances. Most patients with Hodgkin lymphoma live long and healthy lives following successful treatment. […] Many people treated for non-Hodgkin lymphoma will receive some form of chemotherapy, radiation therapy, biologic therapy, immunotherapy, or a combination of these. Bone marrow, stem cell transplantation, or CAR T-cell therapy may sometimes be used. Surgery may be used under special circumstances, but primarily to obtain a biopsy for diagnostic purposes.

• #3 Lymphoma: Symptoms, Causes and Treatment

  https://my.clevelandclinic.org/health/diseases/22225-lymphoma

  Lymphoma is a term for a group of blood cancers in your lymphatic system. Healthcare providers can successfully treat and often cure it. […] Often, treatment can put lymphoma into remission or cure it. […] Common lymphoma treatments include: Chemotherapy, Radiation therapy, Targeted therapy, Immunotherapy, CAR T-cell therapy, Stem cell (bone marrow) transplantation. […] Your provider may recommend palliative care as part of your treatment plan. Palliative care focuses on helping you manage symptoms and treatment side effects. […] That said, treatment often puts lymphoma into remission or cures the condition. Remission means you dont have lymphoma symptoms and tests dont find signs of lymphoma. […] Overall, survival rate data show 89% of people with Hodgkin lymphoma and 74% of people with non-Hodgkin lymphoma were alive five years after diagnosis.

• #4 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Well, I think it’s important to recognize what the goals of treatment are. Low-grade lymphomas have an advantage in that they can take a very long time to cause any symptoms, and certainly a very long time to put the patient’s health at risk. However, we do not have a curative treatment that will fix the cancer right away. So we want to weigh up the potential risks and side effects that come with treatment compared to, clearly, the risks and side effects that come from the cancer. So, if you have a cancer that is very low-grade, growing very slowly, giving you no symptoms, we would hold off on treatment and only initiate it when you truly need it. […] Many types of treatments exist for lymphoma. Treatments include radiation, chemotherapy, immunotherapy, targeted therapy and bone marrow transplant, also called stem cell transplant. Sometimes, a combination of treatments is used. The treatment that’s best for you will depend on the kind of lymphoma that you have.

• #5 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Although indolent or slow-growing forms of non-Hodgkin lymphoma are not currently curable, the prognosis is still very good. Patients may live for 20 years or more following an initial diagnosis. In certain patients with an indolent form of the disease, treatment may not be necessary until there are signs of progression. Response to treatment can also change over time. Treatment that worked initially may be ineffective the next time, making it necessary to always keep abreast of the latest information on new or experimental treatment options. […] With active surveillance, patients do not receive any anti-lymphoma treatments but their health and disease are monitored through regular checkup visits and follow-up evaluation procedures. […] Supportive care drugs may be used to address conditions caused by cancer or its treatment.

• #6 Non-Hodgkin Lymphoma Treatment – NCI

  https://www.cancer.gov/types/lymphoma/patient/adult-nhl-treatment-pdq

  Non-Hodgkin lymphoma is a disease in which malignant (cancer) cells form in the lymph system. […] Non-Hodgkin lymphoma can be indolent or aggressive. […] The treatments for indolent and aggressive lymphoma are different. […] Treatment is needed if signs or symptoms occur after the cancer disappeared or after initial cancer treatment. […] Treatment for non-Hodgkin lymphoma may cause side effects. […] The following types of treatment are used: Radiation therapy, Chemotherapy, Immunotherapy, Targeted therapy, Plasmapheresis, Watchful waiting, Antibiotic therapy, Surgery, Stem cell transplant. […] For pregnant women with non-Hodgkin lymphoma, treatment is carefully chosen to protect the fetus. […] Treatment decisions are based on the mother’s wishes, the stage of the non-Hodgkin lymphoma, and the trimester of the pregnancy. […] Treatment of aggressive non-Hodgkin lymphoma during pregnancy may include the following: Treatment given right away based on the type of non-Hodgkin lymphoma to increase the mother’s chance of survival. […] Treatment may include combination chemotherapy and rituximab.

• #7 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Treatment for lymphoma doesn’t always need to start right away. Some types of lymphoma grow very slowly. You and your healthcare professional may decide to wait and have treatment if the cancer starts to cause symptoms. […] Chemotherapy treats cancer with strong medicines. Most chemotherapy medicines are given through a vein. Some come in pill form. Two or more of these medicines together are often used to treat lymphoma. […] Immunotherapy for cancer is a treatment with medicine that helps the body’s immune system to kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn’t be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells. It can be given for different types of lymphoma.

• #8

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  Non-Hodgkin lymphoma is usually treated with chemotherapy or radiotherapy, although some people may not need treatment straight away. […] The recommended treatment plan will depend on your general health and age, as many of the treatments can put a strain on the body. […] Discussions about your treatment plan will usually take place with several doctors and other health professionals who specialise in different aspects of treating lymphoma. […] Your MDT will recommend the best treatment options for you. […] If non-Hodgkin lymphoma is low grade (slow developing) and you’re well, a period of „watch and wait” is often recommended. […] Chemotherapy is a widely used treatment for non-Hodgkin lymphoma that involves using medicine to kill cancer cells. […] It may be used on its own, combined with biological therapy, or combined with radiotherapy.

• #9 Lymphoma: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0101/p34.html

  Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. […] Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. An open lymph node biopsy is preferred for diagnosis. […] Chemotherapy treatment plans differ between the main subtypes of lymphoma. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy.

• #10 Lymphoma: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0101/p34.html

  Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy. […] The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used. […] Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.

• #11 Lymphoma: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0101/p34.html

  Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. […] Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. An open lymph node biopsy is preferred for diagnosis. […] Chemotherapy treatment plans differ between the main subtypes of lymphoma. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy.

• #12 Lymphoma: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0101/p34.html

  Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy. […] The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used. […] Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.

• #13 Non-Hodgkin Lymphoma Treatment & Pharmacologic Management

  https://www.cancertherapyadvisor.com/ddi/non-hodgkin-lymphoma-pharmacological-treatment/

  For second-line therapy of patients who do not intend to proceed with HDT/ASCR, the following regimens are listed as preferred by the NCCN: CAR T-cell therapy, if eligible, including lisocabtagene maraleucel, Polatuzumab vedotin-piiqbendamustinerituximab, Tafasitamab-cxixl+lenalidomide. […] Nonchemotherapy options such as ibrutinib or lenalidomiderituximab may be considered in certain circumstances. […] The preferred first-line treatments for patients with follicular lymphoma include bendamustine+obinutuzumab or rituximab; CHOP+obinutuzumab or rituximab; CVP (cyclophosphamide, vincristine sulfate, prednisone)+obinutuzumab or rituximab; or lenalidomide+rituximab. […] For patients with relapsed or refractory follicular lymphoma, the following treatment regimens are preferred, per the NCCN: Bendamustine+obinutuzumab or rituximab (not recommended if treated with prior bendamustine), CHOP+obinutuzumab or rituximab, CVP+obinutuzumab or rituximab, Lenalidomide+rituximab.

• #14 Chemotherapy for lymphoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/chemotherapy-for-lymphoma

  Chemotherapy is often used to treat lymphoma. It uses anti-cancer (cytotoxic) drugs to destroy lymphoma cells. Cytotoxic means the drugs are toxic to cells. […] Most people have chemotherapy as an outpatient. Usually, you have a combination of different chemotherapy drugs. The drugs are usually given as liquids into a vein (intravenously) or as tablets. […] Your course of treatment is usually given over a few days. But sometimes you have it all in one day. After your first treatment, you have a break of a few weeks without treatment. This is called a cycle of treatment. The break allows your body to recover from any side effects before you start the next cycle. […] Your whole course of treatment may last several months. During this time, you have regular check-ups at the hospital. You usually have a scan before starting treatment and then again at the end. You may also have a scan part way through your course of treatment. These scans show your doctors if the treatment has shrunk the lymphoma.

• #15 Chemotherapy for lymphoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/chemotherapy-for-lymphoma

  Chemotherapy is often used to treat lymphoma. It uses anti-cancer (cytotoxic) drugs to destroy lymphoma cells. Cytotoxic means the drugs are toxic to cells. […] Most people have chemotherapy as an outpatient. Usually, you have a combination of different chemotherapy drugs. The drugs are usually given as liquids into a vein (intravenously) or as tablets. […] Your course of treatment is usually given over a few days. But sometimes you have it all in one day. After your first treatment, you have a break of a few weeks without treatment. This is called a cycle of treatment. The break allows your body to recover from any side effects before you start the next cycle. […] Your whole course of treatment may last several months. During this time, you have regular check-ups at the hospital. You usually have a scan before starting treatment and then again at the end. You may also have a scan part way through your course of treatment. These scans show your doctors if the treatment has shrunk the lymphoma.

• #16 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Clinical trials are appropriate for patients at all stages of disease. The purpose of a clinical trial is to safely monitor the effects of a drug on patients over time and to identify more effective therapies for specific diseases. By participating in a clinical trial, patients may or may not get access to the newest therapies but will receive quality care in a very carefully controlled and supportive environment. […] The term immunotherapy (also called immune-oncology) refers to treatments that interact with the immune system. […] Palliative care is specialized medical care for people living with a serious illness, such as cancer or heart failure. Palliative care is meant to enhance a persons current care by focusing on the quality of life for them and their family. […] Radiation therapy (also called radiotherapy) uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation is a local therapy, which means it only affects cancer cells in the treated area. Radiation is sometimes used alone for certain localized lymphomas, either nodal or extranodal, or may be combined with chemotherapy.

• #17

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  Chemotherapy is usually given over a period of a few months on an outpatient basis, which means you get treatment during the day and shouldn’t have to stay in hospital overnight. […] If non-Hodgkin lymphoma doesn’t get better with initial treatment (known as refractory lymphoma), you may have a course of chemotherapy at a stronger dose. […] Radiotherapy is most often used to treat early-stage non-Hodgkin lymphoma, where the cancer is only in one part of the body. […] For some types of non-Hodgkin lymphoma, you may have a type of medicine called a monoclonal antibody. […] These medicines attach themselves to both healthy and cancerous cells, and signal to the immune system to attack and kill the cells. […] Steroid medicine is commonly used in combination with chemotherapy to treat non-Hodgkin lymphoma.

• #18

  https://www.nhs.uk/conditions/hodgkin-lymphoma/treatment/

  If regular chemotherapy is unsuccessful or Hodgkin lymphoma returns after treatment, you may have a course of chemotherapy at a higher dose. […] Radiotherapy is most often used to treat early-stage Hodgkin lymphoma, where the cancer is only in 1 part of the body. […] Radiotherapy itself is painless, but it can have some significant side effects. […] Steroid medicine is sometimes used in combination with chemotherapy as a more intensive treatment for advanced Hodgkin lymphoma, or if initial treatment has not worked. […] You might be offered a biological medicine if you’re diagnosed with certain rare types of Hodgkin lymphoma, or if other treatments have not worked or are not suitable for you. […] Biological medicines are also known as targeted therapies. They work by targeting cancer cells, or helping your immune system to attack cancer cells.

• #19 Lymphoma Cancer Treatment

  https://www.radiologyinfo.org/en/info/lymphoma-cancer-therapy

  Lymphoma Cancer Treatment […] What are my treatment options? […] Treatment options overview […] Treatment depends on the type and stage of your lymphoma. It also depends on your age, overall health, medical history, and tolerance for specific therapies. Sometimes, the disease is advanced but slow growing with no symptoms. If so, your doctor may take a „wait-and-see” approach. […] Standard options include: […] Chemotherapy is a primary treatment for lymphoma. You may receive it by vein (IV) or in pill form. Your doctor may use it alone or with radiation therapy. Chemotherapy may decrease the chance lymphoma will return in other areas of the body. Like radiation therapy, it can ease symptoms and extend life for patients with tumors that have spread. Your doctor will usually give chemotherapy over time with periods of no treatment. This lowers possible side effects, such as abnormal blood-cell counts, fatigue, diarrhea, mouth sores, and risk of infection.

• #20 Lymphoma Cancer Treatment

  https://www.radiologyinfo.org/en/info/lymphoma-cancer-therapy

  Radiation therapy uses high-energy radiation to shrink tumors and kill cancer cells. Your doctor may use it alone or with chemotherapy. […] How effective is modern radiation treatment of lymphoma? […] Radiation is extremely effective in treating lymphoma. This is because most lymphomas are quite radiosensitive. Meaning, they respond well to moderate doses of radiation. For early stage, intermediate, and high-grade lymphoma, patients receive chemotherapy and then radiation to the initial area(s) of concern. In advanced disease, your doctor may add radiation to previously bulky sites or sites that are not responding well to treatment. Your doctor may also use radiation in very low doses to control local symptoms in any stage. For some unusual types of low-grade lymphoma that present with limited disease, radiation therapy alone may be curative.

• #21 Lymphoma Cancer Treatment

  https://www.radiologyinfo.org/en/info/lymphoma-cancer-therapy

  Radiation therapy uses high-energy radiation to shrink tumors and kill cancer cells. Your doctor may use it alone or with chemotherapy. […] How effective is modern radiation treatment of lymphoma? […] Radiation is extremely effective in treating lymphoma. This is because most lymphomas are quite radiosensitive. Meaning, they respond well to moderate doses of radiation. For early stage, intermediate, and high-grade lymphoma, patients receive chemotherapy and then radiation to the initial area(s) of concern. In advanced disease, your doctor may add radiation to previously bulky sites or sites that are not responding well to treatment. Your doctor may also use radiation in very low doses to control local symptoms in any stage. For some unusual types of low-grade lymphoma that present with limited disease, radiation therapy alone may be curative.

• #22 Lymphoma Cancer Treatment

  https://www.radiologyinfo.org/en/info/lymphoma-cancer-therapy

  Radiation therapy uses high-energy radiation to shrink tumors and kill cancer cells. Your doctor may use it alone or with chemotherapy. […] How effective is modern radiation treatment of lymphoma? […] Radiation is extremely effective in treating lymphoma. This is because most lymphomas are quite radiosensitive. Meaning, they respond well to moderate doses of radiation. For early stage, intermediate, and high-grade lymphoma, patients receive chemotherapy and then radiation to the initial area(s) of concern. In advanced disease, your doctor may add radiation to previously bulky sites or sites that are not responding well to treatment. Your doctor may also use radiation in very low doses to control local symptoms in any stage. For some unusual types of low-grade lymphoma that present with limited disease, radiation therapy alone may be curative.

• #23 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Treatment for lymphoma doesn’t always need to start right away. Some types of lymphoma grow very slowly. You and your healthcare professional may decide to wait and have treatment if the cancer starts to cause symptoms. […] Chemotherapy treats cancer with strong medicines. Most chemotherapy medicines are given through a vein. Some come in pill form. Two or more of these medicines together are often used to treat lymphoma. […] Immunotherapy for cancer is a treatment with medicine that helps the body’s immune system to kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn’t be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells. It can be given for different types of lymphoma.

• #24 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Clinical trials are appropriate for patients at all stages of disease. The purpose of a clinical trial is to safely monitor the effects of a drug on patients over time and to identify more effective therapies for specific diseases. By participating in a clinical trial, patients may or may not get access to the newest therapies but will receive quality care in a very carefully controlled and supportive environment. […] The term immunotherapy (also called immune-oncology) refers to treatments that interact with the immune system. […] Palliative care is specialized medical care for people living with a serious illness, such as cancer or heart failure. Palliative care is meant to enhance a persons current care by focusing on the quality of life for them and their family. […] Radiation therapy (also called radiotherapy) uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation is a local therapy, which means it only affects cancer cells in the treated area. Radiation is sometimes used alone for certain localized lymphomas, either nodal or extranodal, or may be combined with chemotherapy.

• #25 Types of Immunotherapy for Lymphoma Treatment

  https://www.webmd.com/cancer/lymphoma/treatment-types

  Your doctor may talk to you about using immunotherapy to help treat your lymphoma. Its a newer type of cancer treatment that works with your natural immune system to find and kill cancer cells in your body. […] After successful immunotherapy, your cancer’s not as likely to return because your immune system has learned to recognize and target that type of tumor cell if it comes back. […] Some forms of it are quite high-tech, and some side effects can be serious or life-threatening. […] These are the different kinds of immunotherapy you may get for lymphoma: Monoclonal antibodies, Immunomodulating drugs, Immune checkpoint inhibitors, CAR T-cell therapy. […] Rituximab (Rituxan) is the monoclonal antibody that doctors most often use to treat lymphoma. This drug targets the CD20 antigen, which many types of lymphoma make too much of.

• #26 Types of Immunotherapy for Lymphoma Treatment

  https://www.webmd.com/cancer/lymphoma/treatment-types

  You might get a monoclonal antibody that targets a different antigen thats found on your lymphoma cells. For instance, you may get alemtuzumab (Campath) if your cells have the CD52 antigen. […] There are also monoclonal antibodies that target cancer cells and deliver cancer-killing drugs to lymphoma cells. […] You may get a monoclonal antibody called brentuximab vedotin (Adcetris) if you cant have a stem cell transplant or classic Hodgkin’s lymphoma comes back after treatment. […] If your lymphoma stops responding to chemo, your doctor may talk to you about trying the monoclonal antibody called alemtuzumab (Campath) or brentuximab vedotin (Adcetris). […] These drugs help your immune system work better, but doctors dont know exactly how they work. […] Cells have proteins on them called checkpoints. They help your immune system know the difference between good and bad cells.

• #27 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Chemotherapy is the mainstay of treatment for HL. A combination chemotherapy regimen consists of two or more chemotherapy drugs. […] Chemotherapy is given in cycles of treatment that are separated by periods of rest. Chemotherapy drugs can have strong side effects so the body needs time to recover in between treatment cycles. […] Early-Stage Classical Hodgkin Lymphoma (cHL): Chemotherapy combinations (administered with or without radiation therapy) […] Advanced-Stage cHL: Chemotherapy combinations (occasionally, chemotherapy is followed by involved-site radiation therapy (ISRT) […] Brentuximab vedotin (Adcetris) is approved for the treatment of adult Hodgkin lymphoma patients. […] Nivolumab (Opdivo) and pembrolizumab (Keytruda) can be used for some patients with HL that has become refractory (come back or spread during treatment), or that has relapsed (returned) after the patient has completed other treatments.

• #28 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Your lymphoma cells might be tested to see if targeted therapy will help you. […] Radiation therapy treats cancer with powerful energy beams. The energy comes from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points in your body. […] Chimeric antigen receptor (CAR)-T cell therapy, also called CAR-T cell therapy, trains your immune system cells to fight lymphoma. This treatment begins with removing some white blood cells, including T cells, from your blood. The cells are sent to a lab. In the lab, the cells are treated to recognize the lymphoma cells. The cells are then put back into your body. They then can find and destroy the lymphoma cells.

• #29 4 Innovative Non-Hodgkin Lymphoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/non-hodgkin-lymphoma/non-hodgkin-lymphoma-treatment.html

  Proton therapy delivers high radiation doses directly to the tumor site, with minimal damage to nearby healthy tissue. […] Immunotherapy for Non-Hodgkin lymphoma may include: Chimeric Antigen Receptor (CAR) T cell therapy, Monoclonal antibodies including rituximab, Biological therapies that develop antibodies to help the body fight the cancer, Immune modulators, such lenalidomide, that modify the environment of the tumor cell and allow the immune system to kill the cancer, Targeted therapies that attack cancer cells by using small molecules to block pathways cells used to survive and multiply, Small molecule treatments. […] If non-Hodgkin lymphoma does not respond to chemotherapy or if it returns, your doctor may recommend a stem cell transplant. […] This approach involves closely monitoring non-Hodgkin lymphoma without active treatment. Sometimes this is appropriate for some patients with low-grade lymphomas.

• #30 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Immunotherapy, also called biologic therapy, uses the immune system to more effectively fight cancer. The body and lab-made substances help strengthen and guide the body’s natural defenses against cancer. […] The FDA has recently approved mosunetuzumab-axgb (Lunsumio), a new category of immunotherapy for advanced follicular lymphoma. This bispecific antibody is the first of its kind to treat follicular lymphoma, a type of non-Hodgkin lymphoma. This subtype of non-Hodgkin lymphoma has had limited treatment options, especially when patients do not respond to other treatment methods or the lymphoma has returned. Lunsumio works by engaging B and T cells to destroy cancer cells. […] Hodgkin lymphoma treatments are also being researched and new treatment therapies have recently been approved.

• #31 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  A more recent approach is the use of brentuximab vedotin (Adcetris). This drug treats Hodgkin’s by targeting CD30 protein, a marker for Hodgkin lymphoma. It can be used alone or in combination with chemotherapy and is approved for initial treatment in patients with advanced Hodgkin lymphoma. This can also be used for patients with a high risk of recurrent lymphoma after treatment. […] The FDA has approved two other medications, nivolumab (Opdivo) and pembrolizumab (Keytruda), for patients with recurrent Hodgkin lymphoma after other treatments. These immune checkpoint inhibitors make it possible for the body to differentiate cancer cells from healthy cells so that the immune system can be turned on to destroy the cancer cells.

• #32 Lymphoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lymphoma/diagnosis-treatment/drc-20352642

  Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Your lymphoma cells might be tested to see if targeted therapy will help you. […] Radiation therapy treats cancer with powerful energy beams. The energy comes from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points in your body. […] Chimeric antigen receptor (CAR)-T cell therapy, also called CAR-T cell therapy, trains your immune system cells to fight lymphoma. This treatment begins with removing some white blood cells, including T cells, from your blood. The cells are sent to a lab. In the lab, the cells are treated to recognize the lymphoma cells. The cells are then put back into your body. They then can find and destroy the lymphoma cells.

• #33 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  The ability to transplant stem cells allows physicians to use higher doses of chemotherapy to treat the cancer than the body would normally tolerate, increasing the probability of killing cancer cells. If the chemotherapy is followed by an infusion of stem cells, these new stem cells can replace the cells in the bone marrow that were destroyed during the chemotherapy treatment. […] Most types of targeted therapy help treat lymphoma by interfering with specific proteins that help tumors grow and spread throughout the body. […] The first steps in participating in treatment are to ask questions, learn about options, and work closely with the doctor. Being a self-advocate and an active participant in ones own healthcare can be a positive experience and may help restore hope and control following a diagnosis.

• #34 Non-Hodgkin Lymphoma Treatment & Pharmacologic Management

  https://www.cancertherapyadvisor.com/ddi/non-hodgkin-lymphoma-pharmacological-treatment/

  Patients with relapsed or refractory disease may receive second-line treatment with the following preferred regimens: Covalent BTK inhibitors (continuous), including acalabrutinib and zanubrutinib, Lenalidomide with rituximab, Covalent BTK inhibitor (continuous) with ibrutinibrituximab. […] The NCCN provides treatment guidelines for first-line and second-line therapies for patients with these conditions. […] The following tables detail chemotherapy and combination regimens, small molecule inhibitors, and CAR T-cell therapies used to treat patients with NHL. […] The NCCN guidelines specify that an FDA-approved biosimilar is an appropriate substitute for rituximab throughout these treatment regimens.

• #35 Types of Immunotherapy for Lymphoma Treatment

  https://www.webmd.com/cancer/lymphoma/treatment-types

  You might get a monoclonal antibody that targets a different antigen thats found on your lymphoma cells. For instance, you may get alemtuzumab (Campath) if your cells have the CD52 antigen. […] There are also monoclonal antibodies that target cancer cells and deliver cancer-killing drugs to lymphoma cells. […] You may get a monoclonal antibody called brentuximab vedotin (Adcetris) if you cant have a stem cell transplant or classic Hodgkin’s lymphoma comes back after treatment. […] If your lymphoma stops responding to chemo, your doctor may talk to you about trying the monoclonal antibody called alemtuzumab (Campath) or brentuximab vedotin (Adcetris). […] These drugs help your immune system work better, but doctors dont know exactly how they work. […] Cells have proteins on them called checkpoints. They help your immune system know the difference between good and bad cells.

• #36 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  A more recent approach is the use of brentuximab vedotin (Adcetris). This drug treats Hodgkin’s by targeting CD30 protein, a marker for Hodgkin lymphoma. It can be used alone or in combination with chemotherapy and is approved for initial treatment in patients with advanced Hodgkin lymphoma. This can also be used for patients with a high risk of recurrent lymphoma after treatment. […] The FDA has approved two other medications, nivolumab (Opdivo) and pembrolizumab (Keytruda), for patients with recurrent Hodgkin lymphoma after other treatments. These immune checkpoint inhibitors make it possible for the body to differentiate cancer cells from healthy cells so that the immune system can be turned on to destroy the cancer cells.

• #37 Diffuse Large B-Cell Lymphoma (DLBCL) Treatment & Management: Approach Considerations, Management of Early-Stage DLBCL, Treatment of Advanced-Stage Disease

  https://emedicine.medscape.com/article/202969-treatment

  As rituximab changed the treatment paradigm of DLBCL, it has been postulated that the subset of patients with refractory or relapsed DLBCL represent a different patient population than the one studied in pre-rituximab clinical trials. […] The past several years have seen the advent of the following novel agents for treatment of relapsed or recurrent DLBCL: Polatuzumab vedotin (Polivy), Selinexor (Xpovio), Tafasitamab (Monjuvi), Loncastuximab tesirine (Zynlonta), Epcoritamab (Epkinly), Glofitamab (Columvi), Brentuximab vedotin (Adcetris). […] Chimeric antigen receptor (CAR) T-cell therapy utilizes each patient’s own T cells, extracted by leukapheresis. The T cells are sent to a processing facility, where they are genetically engineered with CD19 receptors that seek out cancer cells; the T-cell population is then expanded and infused back into the patient, who has undergone conditioning chemotherapy in preparation for the infusion.

• #38 4 Innovative Non-Hodgkin Lymphoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/non-hodgkin-lymphoma/non-hodgkin-lymphoma-treatment.html

  Proton therapy delivers high radiation doses directly to the tumor site, with minimal damage to nearby healthy tissue. […] Immunotherapy for Non-Hodgkin lymphoma may include: Chimeric Antigen Receptor (CAR) T cell therapy, Monoclonal antibodies including rituximab, Biological therapies that develop antibodies to help the body fight the cancer, Immune modulators, such lenalidomide, that modify the environment of the tumor cell and allow the immune system to kill the cancer, Targeted therapies that attack cancer cells by using small molecules to block pathways cells used to survive and multiply, Small molecule treatments. […] If non-Hodgkin lymphoma does not respond to chemotherapy or if it returns, your doctor may recommend a stem cell transplant. […] This approach involves closely monitoring non-Hodgkin lymphoma without active treatment. Sometimes this is appropriate for some patients with low-grade lymphomas.

• #39 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  The ability to transplant stem cells allows physicians to use higher doses of chemotherapy to treat the cancer than the body would normally tolerate, increasing the probability of killing cancer cells. If the chemotherapy is followed by an infusion of stem cells, these new stem cells can replace the cells in the bone marrow that were destroyed during the chemotherapy treatment. […] Most types of targeted therapy help treat lymphoma by interfering with specific proteins that help tumors grow and spread throughout the body. […] The first steps in participating in treatment are to ask questions, learn about options, and work closely with the doctor. Being a self-advocate and an active participant in ones own healthcare can be a positive experience and may help restore hope and control following a diagnosis.

• #40

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  This is because research has shown that using steroids makes the chemotherapy more effective. […] A type of immunotherapy called CAR T-cell therapy can be used for some types of non-Hodgkin lymphoma, if other treatments have not worked, or your cancer has come back after treatment. […] After your course of treatment ends, you may have a repeat scan to see how well the treatment has worked. […] Following this, you’ll need regular follow-up appointments to monitor your recovery and check for any signs of the cancer returning (known as a relapse).

• #41 Hodgkin lymphoma (Hodgkin disease) – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/diagnosis-treatment/drc-20352650

  Radiation therapy side effects include fatigue and a sunburn-like reaction on the skin at the site where the radiation is aimed. Other side effects depend on where the radiation is aimed. Radiation to the neck can cause dry mouth and hurt the thyroid. Radiation to the chest can hurt the heart and lungs. […] A bone marrow transplant, also called a bone marrow stem cell transplant, involves putting healthy bone marrow stem cells into the body. These cells replace cells hurt by chemotherapy and other treatments. A bone marrow transplant may be an option if Hodgkin lymphoma returns or doesn’t respond to other treatments. […] During a bone marrow transplant, your own blood stem cells are removed, frozen and stored. Next, you receive high-dose chemotherapy and radiation therapy to destroy cancer cells in your body. Finally, the stored stem cells are thawed and put back in your body to help build healthy bone marrow.

• #42 Understanding Your Treatment Options For Lymphoma | Franciscan Health

  https://www.franciscanhealth.org/community/blog/lymphoma-treatment-options

  Immunotherapy is changing the outlook for patients with certain types of lymphoma. […] At Franciscan, we build your lymphoma treatment around you, your health, your goals and your life. For some, the most effective treatment goes beyond chemotherapy. It may include stem cell transplant and CAR T-cell therapy. […] Allogeneic stem cell transplant uses stem cells from a donor. We may consider this treatment for patients with aggressive or relapsed lymphoma. […] Autologous stem cell transplant uses a patients own stem cells, collected before high-dose chemotherapy, to help rebuild healthy blood and immune cells. […] CAR T-cell therapy is a personalized treatment that reprograms your immune cells to find and attack cancer. We typically use this therapy for certain types of lymphoma that havent responded to other treatments.

• #43 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  The ability to transplant stem cells allows physicians to use higher doses of chemotherapy to treat the cancer than the body would normally tolerate, increasing the probability of killing cancer cells. If the chemotherapy is followed by an infusion of stem cells, these new stem cells can replace the cells in the bone marrow that were destroyed during the chemotherapy treatment. […] Most types of targeted therapy help treat lymphoma by interfering with specific proteins that help tumors grow and spread throughout the body. […] The first steps in participating in treatment are to ask questions, learn about options, and work closely with the doctor. Being a self-advocate and an active participant in ones own healthcare can be a positive experience and may help restore hope and control following a diagnosis.

• #44 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  A study by Gaulard et al found that rituximab plus low-dose CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) (R-miniCHOP) offered a good compromise between efficacy and safety in patients older than 80 years. […] Combination chemotherapies are used in younger patients with the goal of achieving a complete remission. […] Randomized trials have shown that adding rituximab to chemotherapy regimens results in higher response rates, longer time to progression, and longer survival than chemotherapy. […] Maintenance therapy with rituximab after induction chemotherapy has been reported to prolong progression-free survival (PFS) in comparison with observation alone in patients with indolent lymphoma. […] High-dose chemotherapy plus stem-cell transplantation is the treatment of choice for patients who have recurrent aggressive lymphomas.

• #45 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment

  Treatment for Hodgkin lymphoma is changing due to new drugs and research findings from clinical trials. Therefore, before treatment begins, it is important to consider getting a second opinion at a center with a Hodgkin lymphoma expert. […] It’s important that your doctor is experienced in treating patients with Hodgkin lymphoma or works in consultation with a Hodgkin lymphoma specialist. This type of specialist is called a hematologist-oncologist. […] For many people with Hodgkin lymphoma, starting treatment helps them focus on moving ahead and looking forward to recovery. Hodgkin lymphoma is considered one of the most curable forms of cancer. […] The goal of Hodgkin lymphoma treatment is to cure the disease. More than 80 percent of all patients diagnosed with Hodgkin lymphoma can be cured by current treatment approaches. The cure rate is higher, approaching 90 percent, in younger patients and those with early-stage favorable disease. Even if disease recurs, many patients can be cured with further treatment.

• #46 How We Treat Hodgkin Lymphoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/hodgkin-lymphoma/treatment

  A large and expanding number of other effective treatment options is available, and you will have the opportunity to speak with your physician about which regimen is most appropriate for you. […] New treatment approaches, including therapies that spur the immune system to attack cancerous lymphocytes, are showing considerable promise. […] Treatment of early favorable Hodgkin lymphoma may include: Combination chemotherapy, Combination chemotherapy with radiation therapy to parts of the body with cancer, Radiation therapy alone to areas of the body with cancer. […] Treatment of recurrent Hodgkin lymphoma may include: Combination chemotherapy, Some types of immunotherapy, Combination chemotherapy followed by high-dose chemotherapy and stem cell transplant with or without radiation therapy, Radiation therapy with or without chemotherapy, Chemotherapy as palliative therapy to relieve symptoms and improve quality of life.

• #47

  https://www.nhs.uk/conditions/hodgkin-lymphoma/treatment/

  If regular chemotherapy is unsuccessful or Hodgkin lymphoma returns after treatment, you may have a course of chemotherapy at a higher dose. […] Radiotherapy is most often used to treat early-stage Hodgkin lymphoma, where the cancer is only in 1 part of the body. […] Radiotherapy itself is painless, but it can have some significant side effects. […] Steroid medicine is sometimes used in combination with chemotherapy as a more intensive treatment for advanced Hodgkin lymphoma, or if initial treatment has not worked. […] You might be offered a biological medicine if you’re diagnosed with certain rare types of Hodgkin lymphoma, or if other treatments have not worked or are not suitable for you. […] Biological medicines are also known as targeted therapies. They work by targeting cancer cells, or helping your immune system to attack cancer cells.

• #48 Hodgkin lymphoma (Hodgkin disease) – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/diagnosis-treatment/drc-20352650

  For nodular lymphocyte-predominant Hodgkin lymphoma, chemotherapy may be combined with targeted therapy and radiation therapy. […] Side effects of chemotherapy depend on the medicines you’re given. Common side effects are nausea and hair loss. Serious long-term complications can occur, such as heart disease, lung damage, fertility problems and other cancers. […] Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body. […] For Hodgkin lymphoma, radiation can be aimed at affected lymph nodes and the nearby areas where the disease might spread. It’s usually used with chemotherapy. Radiation therapy may be the only treatment needed for early-stage nodular lymphocyte-predominant Hodgkin lymphoma.

• #49 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Treatment options for classical Hodgkin lymphoma (cHL) vary depending on the stage of the disease. […] The cure rate for patients in this category exceeds 90 percent. The current treatment approach is to administer chemotherapy alone or chemotherapy followed by radiation therapy to areas of the body where lymphoma was found. […] For patients in this category, the disease is considered to be high risk yet potentially curable. Initial treatment usually consists of either a chemotherapy and radiation or chemotherapy alone. […] Even in advanced stages, HL is curable. In general, patients with advanced-stage HL are treated with more intense regimens of combination chemotherapy. […] Dose-escalated BEACOPP results in a good cure rate, but it puts patients at a slightly higher risk of developing leukemia or other second cancers.

• #50 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Treatment options for classical Hodgkin lymphoma (cHL) vary depending on the stage of the disease. […] The cure rate for patients in this category exceeds 90 percent. The current treatment approach is to administer chemotherapy alone or chemotherapy followed by radiation therapy to areas of the body where lymphoma was found. […] For patients in this category, the disease is considered to be high risk yet potentially curable. Initial treatment usually consists of either a chemotherapy and radiation or chemotherapy alone. […] Even in advanced stages, HL is curable. In general, patients with advanced-stage HL are treated with more intense regimens of combination chemotherapy. […] Dose-escalated BEACOPP results in a good cure rate, but it puts patients at a slightly higher risk of developing leukemia or other second cancers.

• #51 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Treatment options for classical Hodgkin lymphoma (cHL) vary depending on the stage of the disease. […] The cure rate for patients in this category exceeds 90 percent. The current treatment approach is to administer chemotherapy alone or chemotherapy followed by radiation therapy to areas of the body where lymphoma was found. […] For patients in this category, the disease is considered to be high risk yet potentially curable. Initial treatment usually consists of either a chemotherapy and radiation or chemotherapy alone. […] Even in advanced stages, HL is curable. In general, patients with advanced-stage HL are treated with more intense regimens of combination chemotherapy. […] Dose-escalated BEACOPP results in a good cure rate, but it puts patients at a slightly higher risk of developing leukemia or other second cancers.

• #52 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Use of radiation therapy is limited to a small number of patients, those who have areas of bulky disease (large masses) at diagnosis or evidence of residual disease observed on PET-CT scans after treatment. […] During treatment, patients need to be monitored to check their response to therapy. Response to treatment is important in predicting long-term outcomes. […] Imaging tests are used to distinguish between tumor and fibrous (scar) tissue. PET-CT scans help doctors determine if the disease is responding to treatment. […] The Deauville score, based on a five-point scale is the internationally recognized way of using PET-CT to assess treatment response.

• #53 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Use of radiation therapy is limited to a small number of patients, those who have areas of bulky disease (large masses) at diagnosis or evidence of residual disease observed on PET-CT scans after treatment. […] During treatment, patients need to be monitored to check their response to therapy. Response to treatment is important in predicting long-term outcomes. […] Imaging tests are used to distinguish between tumor and fibrous (scar) tissue. PET-CT scans help doctors determine if the disease is responding to treatment. […] The Deauville score, based on a five-point scale is the internationally recognized way of using PET-CT to assess treatment response.

• #54 How We Treat Hodgkin Lymphoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/hodgkin-lymphoma/treatment

  A large and expanding number of other effective treatment options is available, and you will have the opportunity to speak with your physician about which regimen is most appropriate for you. […] New treatment approaches, including therapies that spur the immune system to attack cancerous lymphocytes, are showing considerable promise. […] Treatment of early favorable Hodgkin lymphoma may include: Combination chemotherapy, Combination chemotherapy with radiation therapy to parts of the body with cancer, Radiation therapy alone to areas of the body with cancer. […] Treatment of recurrent Hodgkin lymphoma may include: Combination chemotherapy, Some types of immunotherapy, Combination chemotherapy followed by high-dose chemotherapy and stem cell transplant with or without radiation therapy, Radiation therapy with or without chemotherapy, Chemotherapy as palliative therapy to relieve symptoms and improve quality of life.

• #55 How We Treat Hodgkin Lymphoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/hodgkin-lymphoma/treatment

  Your care will involve the best treatments currently available, combined with new therapies based on research in our laboratories and elsewhere in the field of lymphoma treatment. […] Today, patients have a number of therapy options that are very effective in treating Hodgkin lymphoma, including different forms of chemotherapy, radiotherapy, newer targeted drugs, and immunotherapy. […] Combination chemotherapy (treatments combining several chemotherapy drugs) is the backbone of Hodgkin lymphoma therapy, regardless of the stage. […] The use of therapies that spur the immune system to attack cancerous lymphocytes is showing considerable promise. […] Radiation therapy (radiotherapy) is sometimes incorporated as part of early-stage Hodgkin lymphoma therapy. […] Stem cell transplantation is sometimes used for recurrent Hodgkin lymphoma (when the cancer returns after conventional therapy) that has not responded to initial treatment.

• #56 Hodgkin lymphoma (Hodgkin disease) – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/diagnosis-treatment/drc-20352650

  There is an increased risk of infection after a transplant. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in cancer cells. By blocking these chemicals, targeted therapy can cause cancer cells to die. Targeted therapy is often combined with chemotherapy for treating nodular lymphocyte-predominant Hodgkin lymphoma. […] For classical Hodgkin lymphoma, targeted therapy might be an option in certain situations. […] Immunotherapy for cancer is a treatment with medicine that helps the body’s immune system kill cancer cells. The immune system fights off diseases by attacking germs and other cells that shouldn’t be in the body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells. […] For Hodgkin lymphoma, immunotherapy might be considered in certain situations, such as if the disease doesn’t respond to other treatments.

• #57 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment/chemotherapy-and-drug-therapy

  Chemotherapy is the mainstay of treatment for HL. A combination chemotherapy regimen consists of two or more chemotherapy drugs. […] Chemotherapy is given in cycles of treatment that are separated by periods of rest. Chemotherapy drugs can have strong side effects so the body needs time to recover in between treatment cycles. […] Early-Stage Classical Hodgkin Lymphoma (cHL): Chemotherapy combinations (administered with or without radiation therapy) […] Advanced-Stage cHL: Chemotherapy combinations (occasionally, chemotherapy is followed by involved-site radiation therapy (ISRT) […] Brentuximab vedotin (Adcetris) is approved for the treatment of adult Hodgkin lymphoma patients. […] Nivolumab (Opdivo) and pembrolizumab (Keytruda) can be used for some patients with HL that has become refractory (come back or spread during treatment), or that has relapsed (returned) after the patient has completed other treatments.

• #58 Treating Non-Hodgkin lymphoma (NHL) | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/lymphoma/non-hodgkin/treatment

  High-grade lymphoma is usually fast-growing and needs to be treated straightaway. The aim is to make the lymphoma disappear completely. This is called complete remission. […] The most commonly used treatments are: chemotherapy and steroids, a combination of chemotherapy and a targeted and immunotherapy drug, such as rituximab (chemoimmunotherapy) and steroids. […] Many people with high-grade NHL are cured. But if the lymphoma does not completely respond to treatment your doctor may talk to you about having more intensive treatment. […] Treatment can often cure high-grade NHL. But, in some people, the lymphoma comes back. If this happens, it may be possible to have more treatment to try to cure it. […] Low-grade NHL cannot usually be cured. It nearly always comes back or starts to grow again at some point after treatment. You can have further treatment to control the lymphoma. […] You may have one, or a combination, of the following treatments: chemotherapy with different drugs, targeted therapy and immunotherapies, radiotherapy, stem cell transplant, CAR-T therapy.

• #59 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Blood cancers, including lymphoma, are extremely heterogeneous and can involve a variety of treatment options, often in combination. Some form of chemotherapy, radiation therapy, immunotherapy, or a combination is typically used to treat Hodgkin lymphoma. Bone marrow or stem cell transplantation may also sometimes be done under special circumstances. Most patients with Hodgkin lymphoma live long and healthy lives following successful treatment. […] Many people treated for non-Hodgkin lymphoma will receive some form of chemotherapy, radiation therapy, biologic therapy, immunotherapy, or a combination of these. Bone marrow, stem cell transplantation, or CAR T-cell therapy may sometimes be used. Surgery may be used under special circumstances, but primarily to obtain a biopsy for diagnostic purposes.

• #60 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Although indolent or slow-growing forms of non-Hodgkin lymphoma are not currently curable, the prognosis is still very good. Patients may live for 20 years or more following an initial diagnosis. In certain patients with an indolent form of the disease, treatment may not be necessary until there are signs of progression. Response to treatment can also change over time. Treatment that worked initially may be ineffective the next time, making it necessary to always keep abreast of the latest information on new or experimental treatment options. […] With active surveillance, patients do not receive any anti-lymphoma treatments but their health and disease are monitored through regular checkup visits and follow-up evaluation procedures. […] Supportive care drugs may be used to address conditions caused by cancer or its treatment.

• #61 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Although indolent or slow-growing forms of non-Hodgkin lymphoma are not currently curable, the prognosis is still very good. Patients may live for 20 years or more following an initial diagnosis. In certain patients with an indolent form of the disease, treatment may not be necessary until there are signs of progression. Response to treatment can also change over time. Treatment that worked initially may be ineffective the next time, making it necessary to always keep abreast of the latest information on new or experimental treatment options. […] With active surveillance, patients do not receive any anti-lymphoma treatments but their health and disease are monitored through regular checkup visits and follow-up evaluation procedures. […] Supportive care drugs may be used to address conditions caused by cancer or its treatment.

• #62 Treatment options for non-Hodgkin lymphoma | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/non-hodgkin-lymphoma/treatment/decisions

  The exact choice of treatment depends on which type of high grade NHL you have. You might have: chemotherapy with 3 or 4 different drugs this might be with rituximab (chemoimmunotherapy), chemotherapy to stop lymphoma spreading to your brain. […] After treatment, NHL sometimes doesn’t go away or it comes back. You might have: chemotherapy or chemoimmunotherapy, using a different combination of drugs, stem cell transplant, CAR T-cell therapy, targeted cancer drugs, radiotherapy.

• #63 Non-Hodgkin Lymphoma Treatment & Pharmacologic Management

  https://www.cancertherapyadvisor.com/ddi/non-hodgkin-lymphoma-pharmacological-treatment/

  For second-line therapy of patients who do not intend to proceed with HDT/ASCR, the following regimens are listed as preferred by the NCCN: CAR T-cell therapy, if eligible, including lisocabtagene maraleucel, Polatuzumab vedotin-piiqbendamustinerituximab, Tafasitamab-cxixl+lenalidomide. […] Nonchemotherapy options such as ibrutinib or lenalidomiderituximab may be considered in certain circumstances. […] The preferred first-line treatments for patients with follicular lymphoma include bendamustine+obinutuzumab or rituximab; CHOP+obinutuzumab or rituximab; CVP (cyclophosphamide, vincristine sulfate, prednisone)+obinutuzumab or rituximab; or lenalidomide+rituximab. […] For patients with relapsed or refractory follicular lymphoma, the following treatment regimens are preferred, per the NCCN: Bendamustine+obinutuzumab or rituximab (not recommended if treated with prior bendamustine), CHOP+obinutuzumab or rituximab, CVP+obinutuzumab or rituximab, Lenalidomide+rituximab.

• #64 Treating Non-Hodgkin lymphoma (NHL) | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/lymphoma/non-hodgkin/treatment

  Treatment for non-Hodgkin lymphoma (NHL) depends on the type and stage of the lymphoma you have. Chemotherapy is the most common treatment for NHL. […] There are different types of treatment for NHL. You may need just one type of treatment or a combination of treatments. […] The most common treatment for early stage (stage 1 or 2), low-grade NHL is radiotherapy. It is given to the affected lymph nodes and can usually make the lymphoma disappear completely. Some people are cured after radiotherapy alone. […] Treatment aims to control the lymphoma rather than cure it. It is often very successful at shrinking the lymphoma. You will feel well and will not have any symptoms. This is called remission. […] When low-grade advanced NHL causes symptoms, the most common treatments are: chemotherapy, rituximab or a similar targeted and immunotherapy drug, a combination of chemotherapy and a targeted and immunotherapy drug (called chemoimmunotherapy). These treatments are often very successful at getting the lymphoma into remission.

• #65 About RITUXAN® (rituximab) | Follicular Lymphoma

  https://www.rituxan.com/nhl/about-rituxan/follicular-lymphoma.html

  As initial treatment RITUXAN, with CVP chemotherapy, may be given to treat follicular lymphoma. These drugs work together in different ways to fight cancer. The goal in using this combination of drugs is to keep your cancer from getting worse. […] After treatment for follicular lymphoma, many patients may achieve remission. Ask your doctor if you are eligible to continue RITUXAN treatment. […] Your doctor may decide to prescribe RITUXAN as maintenance therapy if you achieve remission after using RITUXAN (rituximab) and chemotherapy as initial treatment. RITUXAN is prescribed alone, without chemotherapy, every 8 weeks for 12 doses during this phase of the journey. Your goal here is to help keep your disease in remission. […] In one study of patients with follicular lymphoma who received RITUXAN maintenance therapy (after responding to initial RITUXAN therapy plus chemotherapy), patients cut the risk of their disease advancing by almost half (46%) compared with patients who did not receive additional treatment after initial therapy. […] RITUXAN is given once every 8 weeks for 12 doses as maintenance therapy. Severe side effects reported were infections and decreased white blood cell counts.

• #66 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  A study by Gaulard et al found that rituximab plus low-dose CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) (R-miniCHOP) offered a good compromise between efficacy and safety in patients older than 80 years. […] Combination chemotherapies are used in younger patients with the goal of achieving a complete remission. […] Randomized trials have shown that adding rituximab to chemotherapy regimens results in higher response rates, longer time to progression, and longer survival than chemotherapy. […] Maintenance therapy with rituximab after induction chemotherapy has been reported to prolong progression-free survival (PFS) in comparison with observation alone in patients with indolent lymphoma. […] High-dose chemotherapy plus stem-cell transplantation is the treatment of choice for patients who have recurrent aggressive lymphomas.

• #67 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Although indolent or slow-growing forms of non-Hodgkin lymphoma are not currently curable, the prognosis is still very good. Patients may live for 20 years or more following an initial diagnosis. In certain patients with an indolent form of the disease, treatment may not be necessary until there are signs of progression. Response to treatment can also change over time. Treatment that worked initially may be ineffective the next time, making it necessary to always keep abreast of the latest information on new or experimental treatment options. […] With active surveillance, patients do not receive any anti-lymphoma treatments but their health and disease are monitored through regular checkup visits and follow-up evaluation procedures. […] Supportive care drugs may be used to address conditions caused by cancer or its treatment.

• #68 Non-Hodgkin Lymphoma Treatment | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/lymphoma/treatment/non-hodgkin-lymphoma

  Many treatment options are now available for non-Hodgkin lymphoma. These include traditional chemotherapy, targeted drugs, and novel therapies that are available only through clinical trials. […] For people with aggressive B cell non-Hodgkin lymphoma, we commonly recommend a chemotherapy treatment called R-CHOP. […] We’re developing new treatment strategies based on our understanding of why and how lymphoma develops and grows. Biologically targeted drugs can turn off the molecular pathways that drive your lymphoma to grow and divide. […] MSK is an international leader in the development of immunotherapy for the treatment of cancer. […] CAR T cell therapy is an exciting and powerful treatment now available for some patients with diffuse large B-cell lymphoma (DLBCL). […] Many types of lymphoma are highly sensitive to radiation therapy. […] In a stem cell transplant also called a bone marrow transplant a patients blood-forming stem cells are replaced by adding new ones into the bloodstream.

• #69 Diffuse Large B-Cell Lymphoma (DLBCL) Treatment & Management: Approach Considerations, Management of Early-Stage DLBCL, Treatment of Advanced-Stage Disease

  https://emedicine.medscape.com/article/202969-treatment

  Chemotherapy is usually given on an outpatient basis, although patients should be admitted to the hospital if a treatment complication arises. Transfer to an appropriate facility may be necessary for further diagnostic evaluation and medical or surgical interventions. […] In general, the role of surgery in the treatment of DLBCL is limited. Treatment of these tumors is primarily with cytotoxic agents, with or without radiation therapy. However, surgery can be helpful in obtaining tissue for diagnosis or, rarely, to palliate a complication. […] R-CHOP rituximab in combination with cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone is the standard immunochemotherapy regimen for DLBCL. It achieves cures in approximately two thirds of patients with DLBCL. R-CHOP may be administered in a 14-day or a 21-day cycle, and may be followed by radiation therapy.

• #70 Treatment options for non-Hodgkin lymphoma | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/non-hodgkin-lymphoma/treatment/decisions

  Steroids are naturally made by our bodies in small amounts. They help to control many body functions. These include the immune system, reducing inflammation and blood pressure. Prednisolone and dexamethasone are types of steroids. You might have these as part of your NHL treatment. […] Radiotherapy uses high energy rays similar to x-rays to destroy cancer cells. You might have radiotherapy as your main treatment for some low grade NHLs. Or you might have it after chemoimmunotherapy if you have a high grade NHL. […] You can have a stem cell transplant after very high doses of chemotherapy. The chemotherapy kills the lymphoma cells and also the stem cells in your bone marrow. After the chemotherapy you have the new stem cells into your bloodstream through a drip. […] Your treatment depends on which type of NHL you have. The most common types of high grade NHL are: diffuse large B cell lymphoma (DLBCL), Burkitt lymphoma, peripheral T cell lymphoma, such as angioimmunoblastic T cell lymphoma.

• #71 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/hematologic-(blood)-cancers-/non-hodgkin-lymphoma

  The most common lymphoma is non-Hodgkin lymphoma (NHL), which has 35 different subtypes. These variations help us to determine the best treatment for your exact case. There are aggressive (fast-growing) and low-grade or indolent lymphomas. […] The most common types of treatment include: […] Chemotherapy involves taking one or more drugs by oral pill form or intravenously to kill lymphoma cells throughout your body. You may have this treatment along with other types of treatment. […] Immunotherapy makes use of substances made to simulate the protective actions of your immune system. These drugs help your immune system to fight the lymphoma. […] Targeted Therapy uses medicines to attack parts of cancer cells that make them unique from healthy cells. […] Radiation therapy is used to consolidate gains made by systemic treatments, especially in areas where there was a large volume of disease originally or where disease persists after chemotherapy.

• #72 Non-Hodgkin Lymphoma Treatment & Pharmacologic Management

  https://www.cancertherapyadvisor.com/ddi/non-hodgkin-lymphoma-pharmacological-treatment/

  Treatment of Adults with B-Cell Lymphomas Pharmacotherapy Recommendations for Non-Hodgkin Lymphoma Adverse Effects and Drug Interactions Associated with Non-Hodgkin Lymphoma Treatment […] The following treatment recommendations established by the National Comprehensive Cancer Network (NCCN) offer guidance on induction therapy, maintenance therapy, and treatment for relapsed or refractory disease for the most common types of B-cell lymphoma. […] Cure is possible for a substantial number of patients with Burkitt lymphoma by using dose-intensive multiagent chemotherapy regimens. However, this type of cancer grows very quickly, so immediate treatment is important. More than half of people with Burkitt lymphoma can be cured with intensive chemotherapy. […] Treatment recommendations from the NCCN involve chemotherapy and central nervous system prophylaxis with intrathecal chemotherapy.

• #73 Non-Hodgkin Lymphoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15662-non-hodgkin-lymphoma

  Non-Hodgkin lymphoma (NHL) is a group of blood cancers that develop in your lymphatic system. Some forms of NHL are curable, while others require ongoing treatment or management. […] People with non-Hodgkin lymphoma are living longer than ever, thanks to new treatments. In some cases, treatments cure the condition. Other times, the goal of treatment is to put the disease into remission (no signs or symptoms of cancer) for as long as possible. […] There are several types of treatment for non-Hodgkin lymphoma. The treatment you’ll need depends on factors like the type of NHL, the cancer stage and your overall health. Treatments include: Active surveillance, Chemotherapy, Targeted therapy, Immunotherapy, Radiation therapy, Chemotherapy with stem cell transplantation. […] In some cases, treatment can cure non-Hodgkin lymphoma. This means that treatment has eliminated all cancer cells for good. This is more common after treatment for aggressive B-cell lymphomas.

• #74 Non-Hodgkin Lymphoma Treatment & Pharmacologic Management

  https://www.cancertherapyadvisor.com/ddi/non-hodgkin-lymphoma-pharmacological-treatment/

  First-line treatment recommendations for patients with stage I to II DLBCL (excluding stage II with extensive mesenteric disease) include RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) or pola-R-CHP (polatuzumab vedotin-piiq, rituximab, cyclophosphamide, doxorubicin, prednisone). […] High-dose therapy with autologous stem cell rescue (HDT/ASCR) is used as salvage therapy in patients with relapsed or refractory DLBCL. […] Regimens recommended by the NCCN for second-line therapy for patients with DLBCL who intend to proceed with HDT/ASCR include the following: DHA (dexamethasone, cytarabine)+platinum (carboplatin, cisplatin, or oxaliplatin)rituximab, GDP (gemcitabine, dexamethasone, cisplatin)rituximab or (gemcitabine, dexamethasone, carboplatin)rituximab, ICE (ifosfamide, carboplatin, etoposide)rituximab, ESHAP (etoposide, methylprednisolone, cytarabine, cisplatin)rituximab; GemOx (gemcitabine, oxaliplatin)rituximab, MINE (mesna, ifosfamide, mitoxantrone, etoposide)rituximab.

• #75 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  A study by Gaulard et al found that rituximab plus low-dose CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) (R-miniCHOP) offered a good compromise between efficacy and safety in patients older than 80 years. […] Combination chemotherapies are used in younger patients with the goal of achieving a complete remission. […] Randomized trials have shown that adding rituximab to chemotherapy regimens results in higher response rates, longer time to progression, and longer survival than chemotherapy. […] Maintenance therapy with rituximab after induction chemotherapy has been reported to prolong progression-free survival (PFS) in comparison with observation alone in patients with indolent lymphoma. […] High-dose chemotherapy plus stem-cell transplantation is the treatment of choice for patients who have recurrent aggressive lymphomas.

• #76 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  In 2019, polatuzumab vedotin, a CD79b-directed antibody-drug conjugate, gained accelerated approval from the FDA for use in combination with bendamustine and a rituximab product for adults with relapsed or recurrent DLBCL who have received at least 2 prior therapies and are not candidates for transplantation. […] Chimeric antigen receptor (CAR) T-cell therapy is approved for use in adult patients with relapsed or refractory large B-cell lymphoma, after two or more lines of systemic therapy. […] The following CAR T-cell therapies have FDA approval: Axicabtagene ciloleucel (Yescarta), Tisagenlecleucel (Kymriah), and Lisocabtagene maraleucel (Breyanzi).

• #77 Diffuse Large B-Cell Lymphoma (DLBCL) Treatment & Management: Approach Considerations, Management of Early-Stage DLBCL, Treatment of Advanced-Stage Disease

  https://emedicine.medscape.com/article/202969-treatment

  As rituximab changed the treatment paradigm of DLBCL, it has been postulated that the subset of patients with refractory or relapsed DLBCL represent a different patient population than the one studied in pre-rituximab clinical trials. […] The past several years have seen the advent of the following novel agents for treatment of relapsed or recurrent DLBCL: Polatuzumab vedotin (Polivy), Selinexor (Xpovio), Tafasitamab (Monjuvi), Loncastuximab tesirine (Zynlonta), Epcoritamab (Epkinly), Glofitamab (Columvi), Brentuximab vedotin (Adcetris). […] Chimeric antigen receptor (CAR) T-cell therapy utilizes each patient’s own T cells, extracted by leukapheresis. The T cells are sent to a processing facility, where they are genetically engineered with CD19 receptors that seek out cancer cells; the T-cell population is then expanded and infused back into the patient, who has undergone conditioning chemotherapy in preparation for the infusion.

• #78 Treatment options for non-Hodgkin lymphoma | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/non-hodgkin-lymphoma/treatment/decisions

  The exact choice of treatment depends on which type of high grade NHL you have. You might have: chemotherapy with 3 or 4 different drugs this might be with rituximab (chemoimmunotherapy), chemotherapy to stop lymphoma spreading to your brain. […] After treatment, NHL sometimes doesn’t go away or it comes back. You might have: chemotherapy or chemoimmunotherapy, using a different combination of drugs, stem cell transplant, CAR T-cell therapy, targeted cancer drugs, radiotherapy.

• #79 Types of Immunotherapy for Lymphoma Treatment

  https://www.webmd.com/cancer/lymphoma/treatment-types

  This is a very new treatment used for some types of B-cell lymphoma. CAR stands for chimeric antigen receptor. […] The FDA has approved two CAR T-cell therapies for people with non-Hodgkins lymphoma. Axicabtagene ciloleucel (Yescarta) is for certain types of large B-cell lymphoma that haven’t responded to or have come back after at least two other kinds of treatment.

• #80 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  In 2019, polatuzumab vedotin, a CD79b-directed antibody-drug conjugate, gained accelerated approval from the FDA for use in combination with bendamustine and a rituximab product for adults with relapsed or recurrent DLBCL who have received at least 2 prior therapies and are not candidates for transplantation. […] Chimeric antigen receptor (CAR) T-cell therapy is approved for use in adult patients with relapsed or refractory large B-cell lymphoma, after two or more lines of systemic therapy. […] The following CAR T-cell therapies have FDA approval: Axicabtagene ciloleucel (Yescarta), Tisagenlecleucel (Kymriah), and Lisocabtagene maraleucel (Breyanzi).

• #81 Types of Immunotherapy for Lymphoma Treatment

  https://www.webmd.com/cancer/lymphoma/treatment-types

  This is a very new treatment used for some types of B-cell lymphoma. CAR stands for chimeric antigen receptor. […] The FDA has approved two CAR T-cell therapies for people with non-Hodgkins lymphoma. Axicabtagene ciloleucel (Yescarta) is for certain types of large B-cell lymphoma that haven’t responded to or have come back after at least two other kinds of treatment.

• #82 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  In 2019, polatuzumab vedotin, a CD79b-directed antibody-drug conjugate, gained accelerated approval from the FDA for use in combination with bendamustine and a rituximab product for adults with relapsed or recurrent DLBCL who have received at least 2 prior therapies and are not candidates for transplantation. […] Chimeric antigen receptor (CAR) T-cell therapy is approved for use in adult patients with relapsed or refractory large B-cell lymphoma, after two or more lines of systemic therapy. […] The following CAR T-cell therapies have FDA approval: Axicabtagene ciloleucel (Yescarta), Tisagenlecleucel (Kymriah), and Lisocabtagene maraleucel (Breyanzi).

• #83 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  In 2019, polatuzumab vedotin, a CD79b-directed antibody-drug conjugate, gained accelerated approval from the FDA for use in combination with bendamustine and a rituximab product for adults with relapsed or recurrent DLBCL who have received at least 2 prior therapies and are not candidates for transplantation. […] Chimeric antigen receptor (CAR) T-cell therapy is approved for use in adult patients with relapsed or refractory large B-cell lymphoma, after two or more lines of systemic therapy. […] The following CAR T-cell therapies have FDA approval: Axicabtagene ciloleucel (Yescarta), Tisagenlecleucel (Kymriah), and Lisocabtagene maraleucel (Breyanzi).

• #84 Non-Hodgkin Lymphoma (NHL) Treatment & Management: Approach Considerations, Management of Indolent NHL, Management of Aggressive NHL

  https://emedicine.medscape.com/article/203399-treatment

  In 2019, polatuzumab vedotin, a CD79b-directed antibody-drug conjugate, gained accelerated approval from the FDA for use in combination with bendamustine and a rituximab product for adults with relapsed or recurrent DLBCL who have received at least 2 prior therapies and are not candidates for transplantation. […] Chimeric antigen receptor (CAR) T-cell therapy is approved for use in adult patients with relapsed or refractory large B-cell lymphoma, after two or more lines of systemic therapy. […] The following CAR T-cell therapies have FDA approval: Axicabtagene ciloleucel (Yescarta), Tisagenlecleucel (Kymriah), and Lisocabtagene maraleucel (Breyanzi).

• #85 Lymphoma | Durham, Raleigh, North Carolina | Duke Health

  https://www.dukehealth.org/treatments/cancer/lymphoma

  Systemic chemotherapy is administered via oral medication, by infusion into a vein, or by injection. […] A stem cell or bone marrow transplant replaces lymphoma cells with healthy blood cells. […] We are an authorized treatment center for two FDA-approved CAR T-cell therapies (brand names: Yescarta and Kymriah) for the treatment of certain advanced non-Hodgkin lymphomas. People with advanced non-Hodgkin lymphoma who have failed at least two lines of systemic treatment may be candidates for this one-time treatment. […] Our team — medical, radiation, and surgical oncologists; dermatologists; palliative care specialists; psychologists; infectious disease doctors; radiologists; specially trained nurses; nutritionists; and social workers — meet regularly to discuss your care, collect opinions, and offer coordinated treatment recommendations and follow-up.

• #86 Lymphoma Treatments | The University of Kansas Cancer Center

  https://www.kucancercenter.org/cancer/cancer-types/lymphoma/lymphoma-treatments

  If you have lymphoma, you will find the leading specialists you need at The University of Kansas Cancer Center. Our interdisciplinary team of oncologists and hematologists have years of experience treating people with all types of lymphoma. […] The most common treatment for lymphoma is a combination of chemotherapy and radiation therapy. […] Chemotherapy is the main treatment for most types of lymphoma. […] Radiation therapy uses high-dose X-rays to destroy cancer cells. […] Proton therapy is the leading-edge form of radiation treatment currently available. […] Targeted immunotherapy uses antibodies that attach directly to the lymphoma cells and cause them to die. […] CAR T-cell therapy uses genetically modified T cells (immune system cells) to attack cancerous lymphoma cells. […] Bispecific T-cell engagers are a form of immunotherapy that use the patients own immune cells, the T cells, to engage and destroy the cancer cells.

• #87 Understanding Your Treatment Options For Lymphoma | Franciscan Health

  https://www.franciscanhealth.org/community/blog/lymphoma-treatment-options

  Immunotherapy is changing the outlook for patients with certain types of lymphoma. […] At Franciscan, we build your lymphoma treatment around you, your health, your goals and your life. For some, the most effective treatment goes beyond chemotherapy. It may include stem cell transplant and CAR T-cell therapy. […] Allogeneic stem cell transplant uses stem cells from a donor. We may consider this treatment for patients with aggressive or relapsed lymphoma. […] Autologous stem cell transplant uses a patients own stem cells, collected before high-dose chemotherapy, to help rebuild healthy blood and immune cells. […] CAR T-cell therapy is a personalized treatment that reprograms your immune cells to find and attack cancer. We typically use this therapy for certain types of lymphoma that havent responded to other treatments.

• #88 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Immunotherapy, also called biologic therapy, uses the immune system to more effectively fight cancer. The body and lab-made substances help strengthen and guide the body’s natural defenses against cancer. […] The FDA has recently approved mosunetuzumab-axgb (Lunsumio), a new category of immunotherapy for advanced follicular lymphoma. This bispecific antibody is the first of its kind to treat follicular lymphoma, a type of non-Hodgkin lymphoma. This subtype of non-Hodgkin lymphoma has had limited treatment options, especially when patients do not respond to other treatment methods or the lymphoma has returned. Lunsumio works by engaging B and T cells to destroy cancer cells. […] Hodgkin lymphoma treatments are also being researched and new treatment therapies have recently been approved.

• #89 Diffuse Large B-Cell Lymphoma (DLBCL) Treatment & Management: Approach Considerations, Management of Early-Stage DLBCL, Treatment of Advanced-Stage Disease

  https://emedicine.medscape.com/article/202969-treatment

  As rituximab changed the treatment paradigm of DLBCL, it has been postulated that the subset of patients with refractory or relapsed DLBCL represent a different patient population than the one studied in pre-rituximab clinical trials. […] The past several years have seen the advent of the following novel agents for treatment of relapsed or recurrent DLBCL: Polatuzumab vedotin (Polivy), Selinexor (Xpovio), Tafasitamab (Monjuvi), Loncastuximab tesirine (Zynlonta), Epcoritamab (Epkinly), Glofitamab (Columvi), Brentuximab vedotin (Adcetris). […] Chimeric antigen receptor (CAR) T-cell therapy utilizes each patient’s own T cells, extracted by leukapheresis. The T cells are sent to a processing facility, where they are genetically engineered with CD19 receptors that seek out cancer cells; the T-cell population is then expanded and infused back into the patient, who has undergone conditioning chemotherapy in preparation for the infusion.

• #90 Diffuse Large B-Cell Lymphoma (DLBCL) Treatment & Management: Approach Considerations, Management of Early-Stage DLBCL, Treatment of Advanced-Stage Disease

  https://emedicine.medscape.com/article/202969-treatment

  As rituximab changed the treatment paradigm of DLBCL, it has been postulated that the subset of patients with refractory or relapsed DLBCL represent a different patient population than the one studied in pre-rituximab clinical trials. […] The past several years have seen the advent of the following novel agents for treatment of relapsed or recurrent DLBCL: Polatuzumab vedotin (Polivy), Selinexor (Xpovio), Tafasitamab (Monjuvi), Loncastuximab tesirine (Zynlonta), Epcoritamab (Epkinly), Glofitamab (Columvi), Brentuximab vedotin (Adcetris). […] Chimeric antigen receptor (CAR) T-cell therapy utilizes each patient’s own T cells, extracted by leukapheresis. The T cells are sent to a processing facility, where they are genetically engineered with CD19 receptors that seek out cancer cells; the T-cell population is then expanded and infused back into the patient, who has undergone conditioning chemotherapy in preparation for the infusion.

• #91 Understanding Your Treatment Options For Lymphoma | Franciscan Health

  https://www.franciscanhealth.org/community/blog/lymphoma-treatment-options

  Thats why early, personalized treatment is so important. […] We dont need to treat all lymphomas immediately. Watch and wait also known as active surveillance may be a suggested approach for certain slow-growing lymphomas. This is especially true if a patient does not have symptoms. […] Your cancer care team may use this approach between treatment phases or if you need to improve your health before beginning therapy. […] Were able to offer immunotherapies that require extra certifications and close monitoring, like BiTE therapy (Bispecific T-cell engager) and CAR-T cell therapy, said Levering. […] These advanced treatments for lymphoma arent available in every cancer center. They require experience and expertise to manage their side effects. […] The entire team, from doctors and pharmacists to nurses and nurse navigators, is specially trained to guide you through diagnosis, treatments and recovery safely and with compassion.

• #92 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Clinical trials are appropriate for patients at all stages of disease. The purpose of a clinical trial is to safely monitor the effects of a drug on patients over time and to identify more effective therapies for specific diseases. By participating in a clinical trial, patients may or may not get access to the newest therapies but will receive quality care in a very carefully controlled and supportive environment. […] The term immunotherapy (also called immune-oncology) refers to treatments that interact with the immune system. […] Palliative care is specialized medical care for people living with a serious illness, such as cancer or heart failure. Palliative care is meant to enhance a persons current care by focusing on the quality of life for them and their family. […] Radiation therapy (also called radiotherapy) uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation is a local therapy, which means it only affects cancer cells in the treated area. Radiation is sometimes used alone for certain localized lymphomas, either nodal or extranodal, or may be combined with chemotherapy.

• #93 Hodgkin Lymphoma Treatment | Treatment for Hodgkin Disease | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/treating.html

  It’s important to discuss all treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. You may feel that you need to make a decision quickly, but it’s important to give yourself time to absorb the information you have learned. Ask your cancer care team questions. […] Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the-art cancer treatment. In some cases they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer. […] You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors haven’t mentioned. These methods can include vitamins, herbs, and special diets, or other methods such as acupuncture or massage, to name a few.

• #94 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Lymphoma treatment is quickly evolving for both non-Hodgkin lymphoma and Hodgkin lymphoma. The most recent lymphoma treatments focus on improving drug precision. Treatments like targeted therapies and immunotherapy make it possible to directly focus on specific types of cells and even specific abnormalities within the cells to stop the growth of cancer. […] Depending on the specific subtype of lymphoma, various treatments are available. Previously the primary option was chemotherapy. But cancer researchers, including our own oncologists in the Willamette Valley, have tested new treatment options for lymphomas through clinical trials including: […] Targeted therapy drugs identify and kill specific cancer cells. Because they precisely target a specific type of protein or genetic mutation, there’s less damage to healthy cells than chemotherapy or radiation therapy. The category of targeted therapy is rapidly expanding as researchers learn more about the various proteins and genetic changes in cancer cells that can be treated using this type of drug.

• #95 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Lymphoma treatment is quickly evolving for both non-Hodgkin lymphoma and Hodgkin lymphoma. The most recent lymphoma treatments focus on improving drug precision. Treatments like targeted therapies and immunotherapy make it possible to directly focus on specific types of cells and even specific abnormalities within the cells to stop the growth of cancer. […] Depending on the specific subtype of lymphoma, various treatments are available. Previously the primary option was chemotherapy. But cancer researchers, including our own oncologists in the Willamette Valley, have tested new treatment options for lymphomas through clinical trials including: […] Targeted therapy drugs identify and kill specific cancer cells. Because they precisely target a specific type of protein or genetic mutation, there’s less damage to healthy cells than chemotherapy or radiation therapy. The category of targeted therapy is rapidly expanding as researchers learn more about the various proteins and genetic changes in cancer cells that can be treated using this type of drug.

• #96 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Immunotherapy, also called biologic therapy, uses the immune system to more effectively fight cancer. The body and lab-made substances help strengthen and guide the body’s natural defenses against cancer. […] The FDA has recently approved mosunetuzumab-axgb (Lunsumio), a new category of immunotherapy for advanced follicular lymphoma. This bispecific antibody is the first of its kind to treat follicular lymphoma, a type of non-Hodgkin lymphoma. This subtype of non-Hodgkin lymphoma has had limited treatment options, especially when patients do not respond to other treatment methods or the lymphoma has returned. Lunsumio works by engaging B and T cells to destroy cancer cells. […] Hodgkin lymphoma treatments are also being researched and new treatment therapies have recently been approved.

• #97 Immunotherapy for Non-Hodgkin Lymphoma | Cancer Council NSW

  https://www.cancercouncil.com.au/non-hodgkin-lymphoma/treatment/immunotherapy/

  Immunotherapy uses the body’s own immune system to fight cancer. […] Checkpoint immunotherapy and CAR T-cell therapy are the 2 main types of immunotherapy used for non-Hodgkin lymphoma. Your haematologist will discuss which is best for you. […] The drugs used for non-Hodgkin lymphoma are rapidly changing and other immunotherapy drugs may be available through clinical trials. Ask your doctor about the latest developments. […] Pembrolizumab is a type of immunotherapy drug known as a checkpoint inhibitor. It is available on the Pharmaceutical Benefits Scheme (PBS) for some types of non-Hodgkin lymphoma that have come back or not responded to treatment. It is given as an IV infusion every 3 weeks. […] A new type of immunotherapy used to treat some types of lymphoma is chimeric antigen receptor (CAR) T-cell therapy. This boosts the ability of T-cells to fight cancer.

• #98 Hodgkin Lymphoma Treatment | Treatment for Hodgkin Disease | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/treating.html

  It’s important to discuss all treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. You may feel that you need to make a decision quickly, but it’s important to give yourself time to absorb the information you have learned. Ask your cancer care team questions. […] Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the-art cancer treatment. In some cases they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer. […] You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors haven’t mentioned. These methods can include vitamins, herbs, and special diets, or other methods such as acupuncture or massage, to name a few.

• #99 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Although indolent or slow-growing forms of non-Hodgkin lymphoma are not currently curable, the prognosis is still very good. Patients may live for 20 years or more following an initial diagnosis. In certain patients with an indolent form of the disease, treatment may not be necessary until there are signs of progression. Response to treatment can also change over time. Treatment that worked initially may be ineffective the next time, making it necessary to always keep abreast of the latest information on new or experimental treatment options. […] With active surveillance, patients do not receive any anti-lymphoma treatments but their health and disease are monitored through regular checkup visits and follow-up evaluation procedures. […] Supportive care drugs may be used to address conditions caused by cancer or its treatment.

• #100 Lymphoma: Symptoms, Causes and Treatment

  https://my.clevelandclinic.org/health/diseases/22225-lymphoma

  Lymphoma is a term for a group of blood cancers in your lymphatic system. Healthcare providers can successfully treat and often cure it. […] Often, treatment can put lymphoma into remission or cure it. […] Common lymphoma treatments include: Chemotherapy, Radiation therapy, Targeted therapy, Immunotherapy, CAR T-cell therapy, Stem cell (bone marrow) transplantation. […] Your provider may recommend palliative care as part of your treatment plan. Palliative care focuses on helping you manage symptoms and treatment side effects. […] That said, treatment often puts lymphoma into remission or cures the condition. Remission means you dont have lymphoma symptoms and tests dont find signs of lymphoma. […] Overall, survival rate data show 89% of people with Hodgkin lymphoma and 74% of people with non-Hodgkin lymphoma were alive five years after diagnosis.

• #101 Lymphoma – symptoms, causes, treatment & side effects | healthdirect

  https://www.healthdirect.gov.au/lymphoma

  In some people with slow-growing lymphomas, doctors may recommend a watch and wait approach. This means that you will get regular check-ups, and are only treated when the lymphoma starts to grow faster. […] Like all cancer treatments, lymphoma treatments can cause a wide range of side effects and complications. But not everyone experiences the same side effects. […] If you are being treated for lymphoma, some of the medicines or radiation used may cause you to: lose some or all of your hair, feel nauseous (feel sick), vomit (be sick), feel very tired and washed out, have a sore mouth, have sore skin from radiation, have an increased risk of infections. […] Lymphoma treatments can weaken your immune system, increasing your risk of infection. […] Some lymphoma treatments can cause problems with fertility. […] Currently, there are no proven ways to prevent lymphoma and no routine screening tests.

• #102 Lymphoma treatment | Blood Cancer UK

  https://bloodcancer.org.uk/understanding-blood-cancer/lymphoma/treatments-for-lymphoma/

  The treatments you have will depend on the type of lymphoma you have, how far it has spread (its stage) and whether you have symptoms. […] These are some of the common treatments. You might have these treatments on their own or in combination. […] Some people with slow-developing blood cancers dont need treatment straight away this is called active monitoring. […] Chemotherapy uses drugs to kill cancer cells or stop them from growing. […] You may also have radiotherapy. Radiotherapy uses high-energy rays to kill cancer cells in a specific area. […] There are other drug therapies that can be used on their own or with chemotherapy. […] Targeted therapies are drugs that work by targeting proteins or genetic changes that cancer cells have, which normal cells dont have. […] Steroids are drugs that can make some chemotherapy treatments more effective and help you feel less sick during treatment. […] If you have diffuse large B-cell lymphoma, you might also have injections called growth factor injections to encourage your body to make more white blood cells.

• #103 Lymphoma – symptoms, causes, treatment & side effects | healthdirect

  https://www.healthdirect.gov.au/lymphoma

  In some people with slow-growing lymphomas, doctors may recommend a watch and wait approach. This means that you will get regular check-ups, and are only treated when the lymphoma starts to grow faster. […] Like all cancer treatments, lymphoma treatments can cause a wide range of side effects and complications. But not everyone experiences the same side effects. […] If you are being treated for lymphoma, some of the medicines or radiation used may cause you to: lose some or all of your hair, feel nauseous (feel sick), vomit (be sick), feel very tired and washed out, have a sore mouth, have sore skin from radiation, have an increased risk of infections. […] Lymphoma treatments can weaken your immune system, increasing your risk of infection. […] Some lymphoma treatments can cause problems with fertility. […] Currently, there are no proven ways to prevent lymphoma and no routine screening tests.

• #104 Treatment options | Cancer Australia

  https://www.canceraustralia.gov.au/cancer-types/lymphoma/treatment-options

  Lymphoma treatment plans vary based on disease stage, location, symptoms, and patient health, and may involve surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, stem cell transplants, or active monitoring. […] Treatment for lymphoma depends on: the stage and grade of the disease, the location of the cancer, the severity of symptoms, your general health and wishes. […] Together with radiation therapy, chemotherapy is one of the main treatments for lymphoma. […] Using chemotherapy to treat lymphoma may cause a side effect called tumour lysis syndrome. […] Steroids may be used to increase the effect of chemotherapy, help destroy lymphoma, and treat nausea or vomiting. […] Together with chemotherapy, radiation therapy is one of the main treatments for lymphoma.

• #105 Recovery after lymphoma treatment | Lymphoma Action

  https://lymphoma-action.org.uk/about-lymphoma-living-and-beyond-lymphoma/recovery-after-lymphoma-treatment

  People often tell us that finishing treatment for lymphoma can bring a range of emotions. […] You should be offered personalised care and support from your medical team to help you live well after treatment. […] Your doctor or nurse might suggest that you consider a talking therapy. […] If you have any concerns, speak to a member of your medical team. […] Side effects can go on long after treatment has finished. […] If you are struggling with side effects, whatever these are, speak to your medical team for advice and to find out how they can support you. […] Your medical team can give you advice about living well after treatment. […] The general guidance is to have a healthy lifestyle, which includes: eating well, doing exercise that’s suitable for you, looking after your mental wellbeing, including managing stress, keeping a healthy weight, limiting your alcohol intake, not smoking.

• #106 Treatment Options for Lymphoma | Lymphoma Research Foundation

  https://lymphoma.org/understanding-lymphoma/treatment-planning-and-options/treatments/

  Clinical trials are appropriate for patients at all stages of disease. The purpose of a clinical trial is to safely monitor the effects of a drug on patients over time and to identify more effective therapies for specific diseases. By participating in a clinical trial, patients may or may not get access to the newest therapies but will receive quality care in a very carefully controlled and supportive environment. […] The term immunotherapy (also called immune-oncology) refers to treatments that interact with the immune system. […] Palliative care is specialized medical care for people living with a serious illness, such as cancer or heart failure. Palliative care is meant to enhance a persons current care by focusing on the quality of life for them and their family. […] Radiation therapy (also called radiotherapy) uses high-energy x-rays to kill cancer cells and shrink tumors. Radiation is a local therapy, which means it only affects cancer cells in the treated area. Radiation is sometimes used alone for certain localized lymphomas, either nodal or extranodal, or may be combined with chemotherapy.

• #107 Hodgkin Lymphoma Treatment | Treatment for Hodgkin Disease | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/treating.html

  People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care. […] For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life. […] The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don’t hesitate to ask your cancer care team any questions you may have about your treatment options.

• #108 Lymphoma | Causes, Symptoms & Treatments | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/lymphoma

  Treatment for lymphoma depends on the type of lymphoma, the stage of the disease (i.e. how far it has spread around the body) and how fast it is likely to grow. […] Treatment options include chemotherapy, radiation therapy (radiotherapy) and monoclonal antibodies. […] In some cases, a stem cell transplant with strong chemotherapy just beforehand is required if the lymphoma has recurred or where there is a high likelihood of recurrence in the future. […] Early Hodgkin disease is treated with combination chemotherapy plus radiation therapy. […] For patients with non-Hodgkin lymphoma, some can be managed with localised radiotherapy alone, or radiation therapy plus combination chemotherapy. […] If the non-Hodgkin lymphoma is fast-growing, or „aggressive”, successful treatment usually requires starting chemotherapy immediately. […] In some cases of lymphoma, your medical team may talk to you about palliative care. […] Palliative care aims to improve your quality of life by alleviating symptoms of cancer, without aiming to cure it. […] Treatment may include radiation therapy, chemotherapy or other drug therapies.

• #109 How We Treat Hodgkin Lymphoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/hodgkin-lymphoma/treatment

  A large and expanding number of other effective treatment options is available, and you will have the opportunity to speak with your physician about which regimen is most appropriate for you. […] New treatment approaches, including therapies that spur the immune system to attack cancerous lymphocytes, are showing considerable promise. […] Treatment of early favorable Hodgkin lymphoma may include: Combination chemotherapy, Combination chemotherapy with radiation therapy to parts of the body with cancer, Radiation therapy alone to areas of the body with cancer. […] Treatment of recurrent Hodgkin lymphoma may include: Combination chemotherapy, Some types of immunotherapy, Combination chemotherapy followed by high-dose chemotherapy and stem cell transplant with or without radiation therapy, Radiation therapy with or without chemotherapy, Chemotherapy as palliative therapy to relieve symptoms and improve quality of life.

• #110 Treatment for Non-Hodgkin Lymphoma | Cancer Council NSW

  https://www.cancercouncil.com.au/non-hodgkin-lymphoma/treatment/

  When planning your treatment, your doctor will consider the type of non-Hodgkin lymphoma you have, the stage and grade, your age and general health, and your preferences. […] The aim of treatment is to make the signs and symptoms of lymphoma reduce or disappear. This is called remission. Remission may last for a long period of time and most people have a good quality of life. Sometimes non-Hodgkin lymphoma becomes active again and further treatment is required. This is called a relapse. […] Treatment will depend on the type of non-Hodgkin lymphoma and how fast the lymphoma is growing (the grade). […] You may need to be treated quickly. The main treatment option is chemotherapy, often combined with a monoclonal antibody. […] If lymphoma relapses or does not respond to treatment (refractory), you may be offered drug therapies (such as targeted therapy or immunotherapy), more chemotherapy or a stem cell transplant.

• #111 Hodgkin Lymphoma Treatment | Treatment for Hodgkin Disease | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/treating.html

  People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care. […] For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life. […] The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don’t hesitate to ask your cancer care team any questions you may have about your treatment options.

• #112

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  This is because research has shown that using steroids makes the chemotherapy more effective. […] A type of immunotherapy called CAR T-cell therapy can be used for some types of non-Hodgkin lymphoma, if other treatments have not worked, or your cancer has come back after treatment. […] After your course of treatment ends, you may have a repeat scan to see how well the treatment has worked. […] Following this, you’ll need regular follow-up appointments to monitor your recovery and check for any signs of the cancer returning (known as a relapse).

• #113 Treatments for Hodgkin lymphoma | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/hodgkin-lymphoma/treatment

  Hodgkin lymphoma (HL) behaves differently in each person, and a standard follow-up schedule would not work for everyone. People with HL should talk to their doctor about a follow-up plan that suits their individual situation. Follow-up care is often shared among the cancer specialists (oncologists, radiation therapist) and your family doctor.

• #114 Recovery after lymphoma treatment | Lymphoma Action

  https://lymphoma-action.org.uk/about-lymphoma-living-and-beyond-lymphoma/recovery-after-lymphoma-treatment

  People often tell us that finishing treatment for lymphoma can bring a range of emotions. […] You should be offered personalised care and support from your medical team to help you live well after treatment. […] Your doctor or nurse might suggest that you consider a talking therapy. […] If you have any concerns, speak to a member of your medical team. […] Side effects can go on long after treatment has finished. […] If you are struggling with side effects, whatever these are, speak to your medical team for advice and to find out how they can support you. […] Your medical team can give you advice about living well after treatment. […] The general guidance is to have a healthy lifestyle, which includes: eating well, doing exercise that’s suitable for you, looking after your mental wellbeing, including managing stress, keeping a healthy weight, limiting your alcohol intake, not smoking.

• #115

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  This is because research has shown that using steroids makes the chemotherapy more effective. […] A type of immunotherapy called CAR T-cell therapy can be used for some types of non-Hodgkin lymphoma, if other treatments have not worked, or your cancer has come back after treatment. […] After your course of treatment ends, you may have a repeat scan to see how well the treatment has worked. […] Following this, you’ll need regular follow-up appointments to monitor your recovery and check for any signs of the cancer returning (known as a relapse).

• #116

  https://www.nhs.uk/conditions/non-hodgkin-lymphoma/treatment/

  This is because research has shown that using steroids makes the chemotherapy more effective. […] A type of immunotherapy called CAR T-cell therapy can be used for some types of non-Hodgkin lymphoma, if other treatments have not worked, or your cancer has come back after treatment. […] After your course of treatment ends, you may have a repeat scan to see how well the treatment has worked. […] Following this, you’ll need regular follow-up appointments to monitor your recovery and check for any signs of the cancer returning (known as a relapse).

• #117 Non-Hodgkin Lymphoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15662-non-hodgkin-lymphoma

  Most aggressive non-Hodgkin lymphomas that come back usually do so within the first two years after treatment, or they never come back. Still, you’ll need regular check-ups so your healthcare provider can check for relapse. […] With other non-Hodgkin lymphomas, especially indolent ones, you may have this condition in the long term. This means you may need continuous or occasional treatment for the rest of your life. […] It’s important to remember, though, that even when non-Hodgkin lymphoma isn’t curable, current treatments are helping people live longer, fuller lives with this disease.

• #118 Treating Non-Hodgkin lymphoma (NHL) | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/lymphoma/non-hodgkin/treatment

  High-grade lymphoma is usually fast-growing and needs to be treated straightaway. The aim is to make the lymphoma disappear completely. This is called complete remission. […] The most commonly used treatments are: chemotherapy and steroids, a combination of chemotherapy and a targeted and immunotherapy drug, such as rituximab (chemoimmunotherapy) and steroids. […] Many people with high-grade NHL are cured. But if the lymphoma does not completely respond to treatment your doctor may talk to you about having more intensive treatment. […] Treatment can often cure high-grade NHL. But, in some people, the lymphoma comes back. If this happens, it may be possible to have more treatment to try to cure it. […] Low-grade NHL cannot usually be cured. It nearly always comes back or starts to grow again at some point after treatment. You can have further treatment to control the lymphoma. […] You may have one, or a combination, of the following treatments: chemotherapy with different drugs, targeted therapy and immunotherapies, radiotherapy, stem cell transplant, CAR-T therapy.

• #119 Lymphoma Treatment and Care | Nebraska Medicine Omaha, NE

  https://www.nebraskamed.com/cancer/lymphoma

  Our lymphoma team averages 150 to 160 bone and blood marrow transplants a year and have performed more than 4,800 transplants since the program’s founding. […] Our innovative treatments have helped improve success rates and have made blood and marrow transplants a more viable and promising option for a growing number of patients. […] Access to clinical trials affords patients the ability to participate in leading edge treatments that otherwise would not be available to them. […] New approaches for Hodgkin lymphoma are being study through clinical trials at Nebraska Medicine for newly diagnosed patients and patients with relapsed or refractory disease that hold the promise of increasing the rate of remission and finding a cure for all HL patients. […] The proportion of patients with HL, who enter into remission and stay in remission for years, has increased over the last three decades.

• #120 Lymphoma: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0101/p34.html

  Common complications of these therapies are listed in Table 5. […] A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates. […] Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers. […] PET-CT scans, and subsequent Deauville scoring should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma. […] Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force. […] All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.

• #121 Recovery after lymphoma treatment | Lymphoma Action

  https://lymphoma-action.org.uk/about-lymphoma-living-and-beyond-lymphoma/recovery-after-lymphoma-treatment

  People often tell us that finishing treatment for lymphoma can bring a range of emotions. […] You should be offered personalised care and support from your medical team to help you live well after treatment. […] Your doctor or nurse might suggest that you consider a talking therapy. […] If you have any concerns, speak to a member of your medical team. […] Side effects can go on long after treatment has finished. […] If you are struggling with side effects, whatever these are, speak to your medical team for advice and to find out how they can support you. […] Your medical team can give you advice about living well after treatment. […] The general guidance is to have a healthy lifestyle, which includes: eating well, doing exercise that’s suitable for you, looking after your mental wellbeing, including managing stress, keeping a healthy weight, limiting your alcohol intake, not smoking.

• #122 https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment

  https://www.lls.org/lymphoma/hodgkin-lymphoma/treatment

  Treatment for Hodgkin lymphoma is changing due to new drugs and research findings from clinical trials. Therefore, before treatment begins, it is important to consider getting a second opinion at a center with a Hodgkin lymphoma expert. […] It’s important that your doctor is experienced in treating patients with Hodgkin lymphoma or works in consultation with a Hodgkin lymphoma specialist. This type of specialist is called a hematologist-oncologist. […] For many people with Hodgkin lymphoma, starting treatment helps them focus on moving ahead and looking forward to recovery. Hodgkin lymphoma is considered one of the most curable forms of cancer. […] The goal of Hodgkin lymphoma treatment is to cure the disease. More than 80 percent of all patients diagnosed with Hodgkin lymphoma can be cured by current treatment approaches. The cure rate is higher, approaching 90 percent, in younger patients and those with early-stage favorable disease. Even if disease recurs, many patients can be cured with further treatment.

• #123 Non-Hodgkin Lymphoma: Symptoms, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15662-non-hodgkin-lymphoma

  Non-Hodgkin lymphoma (NHL) is a group of blood cancers that develop in your lymphatic system. Some forms of NHL are curable, while others require ongoing treatment or management. […] People with non-Hodgkin lymphoma are living longer than ever, thanks to new treatments. In some cases, treatments cure the condition. Other times, the goal of treatment is to put the disease into remission (no signs or symptoms of cancer) for as long as possible. […] There are several types of treatment for non-Hodgkin lymphoma. The treatment you’ll need depends on factors like the type of NHL, the cancer stage and your overall health. Treatments include: Active surveillance, Chemotherapy, Targeted therapy, Immunotherapy, Radiation therapy, Chemotherapy with stem cell transplantation. […] In some cases, treatment can cure non-Hodgkin lymphoma. This means that treatment has eliminated all cancer cells for good. This is more common after treatment for aggressive B-cell lymphomas.

• #124 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Lymphoma treatment is quickly evolving for both non-Hodgkin lymphoma and Hodgkin lymphoma. The most recent lymphoma treatments focus on improving drug precision. Treatments like targeted therapies and immunotherapy make it possible to directly focus on specific types of cells and even specific abnormalities within the cells to stop the growth of cancer. […] Depending on the specific subtype of lymphoma, various treatments are available. Previously the primary option was chemotherapy. But cancer researchers, including our own oncologists in the Willamette Valley, have tested new treatment options for lymphomas through clinical trials including: […] Targeted therapy drugs identify and kill specific cancer cells. Because they precisely target a specific type of protein or genetic mutation, there’s less damage to healthy cells than chemotherapy or radiation therapy. The category of targeted therapy is rapidly expanding as researchers learn more about the various proteins and genetic changes in cancer cells that can be treated using this type of drug.

• #125 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Immunotherapy, also called biologic therapy, uses the immune system to more effectively fight cancer. The body and lab-made substances help strengthen and guide the body’s natural defenses against cancer. […] The FDA has recently approved mosunetuzumab-axgb (Lunsumio), a new category of immunotherapy for advanced follicular lymphoma. This bispecific antibody is the first of its kind to treat follicular lymphoma, a type of non-Hodgkin lymphoma. This subtype of non-Hodgkin lymphoma has had limited treatment options, especially when patients do not respond to other treatment methods or the lymphoma has returned. Lunsumio works by engaging B and T cells to destroy cancer cells. […] Hodgkin lymphoma treatments are also being researched and new treatment therapies have recently been approved.

• #126 What’s New in Lymphoma Treatments?

  https://www.oregoncancer.com/blog/whats-new-in-lymphoma-treatments

  Lymphoma treatment is quickly evolving for both non-Hodgkin lymphoma and Hodgkin lymphoma. The most recent lymphoma treatments focus on improving drug precision. Treatments like targeted therapies and immunotherapy make it possible to directly focus on specific types of cells and even specific abnormalities within the cells to stop the growth of cancer. […] Depending on the specific subtype of lymphoma, various treatments are available. Previously the primary option was chemotherapy. But cancer researchers, including our own oncologists in the Willamette Valley, have tested new treatment options for lymphomas through clinical trials including: […] Targeted therapy drugs identify and kill specific cancer cells. Because they precisely target a specific type of protein or genetic mutation, there’s less damage to healthy cells than chemotherapy or radiation therapy. The category of targeted therapy is rapidly expanding as researchers learn more about the various proteins and genetic changes in cancer cells that can be treated using this type of drug.

• #127 Treatment for Lymphoma | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/lymphoma/treatment

  Treatment for lymphoma may include radiation, chemotherapy, or a combination of both. It may also include immunotherapy or other new treatments. The treatment that is best for you will depend on many factors, such as the type of lymphoma you have and whether it has come back after previous treatment. […] Your doctor may recommend a treatment based on your specific subtype of lymphoma and its unique genetic profile. […] With biologically targeted therapies, we’re now able to select drugs that zero in on the process that turns lymphocytes into cancer cells. These medicines are often pills that can be taken by mouth. They generally cause fewer side effects than traditional chemotherapy drugs because they are designed to target only tumor cells and leave healthy cells alone. […] At Memorial Sloan Kettering, we are committed to providing all our patients with access to the most effective and innovative treatments. Our lymphoma patients have excellent outcomes and receive superior care.

• #128 What Patients Need to Know About Lymphoma, and the Importance of Personalized Care.

  https://www.medstarhealth.org/blog/lymphoma-cancer-treatment

  Lymphoma is a heterogenous group of blood cancers that requires a balance of focused treatment and personalized care. […] Treatment requires attentive care that is tailored to your personal condition, as well as how fast the cancer is growing. […] With the advent of modern cancer treatment options such as immunotherapies, targeted therapies and precise radiation therapy the outlook is promising. […] Successful lymphoma treatment requires care tailored to a patients specific disease while also considering their other health needs and overall life goals. […] Treatments for lymphoma depend largely on the type, stage, or having any symptoms related to the disease. The goal is to cure the disease or keep it in remission while also mitigating potential short-term and long-term side effects with goals of preserving quality of life.

• #129 How We Treat Non-Hodgkin Lymphoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/non-hodgkin-lymphoma/treatment

  Your care will involve the best treatments currently available, combined with new therapies based on research in our laboratories and elsewhere in the field of lymphoma treatment. […] We carefully consider an array of therapy options, including chemotherapy, radiation therapy, stem cell transplant, targeted therapies, immunotherapy, and clinical trials many of which were developed by scientists in our own laboratories. […] A distinguishing area of our expertise is in determining how to integrate therapies, including identifying types of disease that do not require immediate treatment, determining the optimal cycles of chemotherapy, whether to change the combination of drugs during certain cycles, and whether to include radiation, biologic therapy, and/or a stem cell transplant. […] Today, patients have a number of therapy options, including different forms of chemotherapy, radiation therapy (radiotherapy), new oral drugs, and many other new agents that are accumulating at an incredibly fast pace.

• #130

  https://winshipcancer.emory.edu/cancer-types-and-treatments/lymphoma/treatment.php

  At Winship Cancer Institute of Emory University, lymphoma treatment options include the latest therapies available, and a care team experienced in managing lymphoma. Its treatment personalized for you. […] Every lymphoma diagnosis is unique. The treatments for Hodgkin lymphoma and non-Hodgkin lymphoma depend on the type, stage and grade of the disease. […] Your lymphoma medical care team includes hematologists, pathologists, blood cancer experts, radiologists, radiation oncologists, advanced practice providers and oncology nurses, all of whom work closely together to coordinate a plan that specifically targets your cancer. […] Our lymphoma specialists goal is to develop a strategy that will treat your cancer with the fewest side effects. […] Depending on your diagnosis, the stage and how your particular cancer developed, lymphoma treatment options may vary.

• #131 Lymphoma Program | Stanford Health Care

  https://stanfordhealthcare.org/medical-clinics/lymphoma-program.html

  Leaders in Lymphoma Treatment. At Stanford Medicine, we offer you the most advanced diagnosis and treatment options for Hodgkin and Non-Hodgkin lymphoma, no matter how common or complex the subtype. […] Advanced treatment options, including stem cell transplants and CAR T-cell therapy, which your care team tailors to the lymphoma type and stage. […] At Stanford Medicine, our lymphoma specialists are actively involved in clinical trials, giving you early access to advanced, life-changing therapies. Our researchers have a long history of developing breakthrough technologies for complex and uncommon lymphomas. We developed rituximab, the first monoclonal antibody treatment for B-cell non-Hodgkin lymphoma, which is an integral part of the treatment for most B-cell lymphomas. […] Our lymphoma specialists personalize your treatment plan based on the type of lymphoma you have and whether its slow- or fast-growing. Some slow-growing lymphomas dont require immediate treatment. In those cases, our specialists see you regularly and carefully monitor the lymphoma.

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