Rak gruczołowy in situ
Charakterystyka, pielęgnacja i opieka
Rak gruczołowy in situ (LCIS) to nieprawidłowy rozrost komórek w zrazikach gruczołu piersiowego, klasyfikowany jako zmiana przednowotworowa, a nie nowotwór złośliwy. LCIS charakteryzuje się pozostawaniem komórek w obrębie zrazików bez naciekania tkanek sąsiednich. Wyróżnia się podtypy: klasyczny (CLCIS), pleomorficzny (PLCIS) i florydny, z których PLCIS i florydny wymagają bardziej agresywnego leczenia. Kobiety z LCIS mają 7-12-krotnie zwiększone ryzyko rozwoju inwazyjnego raka piersi, z ryzykiem około 10% w ciągu 10 lat i 20-25% po 20 latach obserwacji. Diagnostyka opiera się na biopsji gruboigłowej lub chirurgicznej oraz badaniu histopatologicznym, gdyż LCIS rzadko jest widoczny w badaniach obrazowych, takich jak mammografia czy USG.
Rak gruczołowy in situ (LCIS) – definicja i charakterystyka
Rak gruczołowy in situ (LCIS – Lobular Carcinoma in Situ) jest rzadką zmianą charakteryzującą się nieprawidłowym rozrostem komórek w obrębie zrazików gruczołu piersiowego, które są strukturami odpowiedzialnymi za produkcję mleka.12 Pomimo nazwy zawierającej termin „carcinoma” (rak), LCIS nie jest klasyfikowany jako nowotwór złośliwy, lecz jako zmiana nieprawidłowa, która zwiększa ryzyko rozwoju inwazyjnego raka piersi w przyszłości.3 W LCIS nieprawidłowe komórki pozostają w granicach zrazików i nie naciekają sąsiednich tkanek, co stanowi kluczową różnicę między tą zmianą a rakiem inwazyjnym.4
LCIS występuje najczęściej u kobiet w wieku 40-50 lat, jednak może pojawić się w każdym wieku.5 Zmiana ta jest zwykle wykrywana przypadkowo podczas biopsji wykonywanej z innych wskazań, np. w trakcie diagnostyki innej zmiany w piersi, gdyż sama nie daje objawów klinicznych i rzadko jest widoczna w badaniach obrazowych, w tym w mammografii.67
Podtypy LCIS i ich znaczenie kliniczne
W praktyce klinicznej wyróżnia się kilka podtypów LCIS, które charakteryzują się odmiennym przebiegiem klinicznym i postępowaniem terapeutycznym:8
- Klasyczny LCIS (CLCIS) – najczęściej rozpoznawany podtyp, charakteryzujący się jednolitymi komórkami o małym jądrze i minimalnej atypii; wymaga obserwacji, ale zwykle nie wymaga interwencji chirurgicznej910
- Pleomorficzny LCIS (PLCIS) – rzadszy, ale bardziej agresywny podtyp, charakteryzujący się większą atypią komórkową; wymaga bardziej agresywnego postępowania, zbliżonego do leczenia DCIS (rak przewodowy in situ)1112
- Florydny LCIS – forma LCIS, która również może wymagać bardziej agresywnego leczenia niż klasyczny LCIS13
Ryzyko rozwoju raka piersi u pacjentek z LCIS
Diagnoza LCIS jest istotnym czynnikiem ryzyka rozwoju inwazyjnego raka piersi w przyszłości. Badania wskazują, że kobiety z LCIS mają 7-12 razy większe ryzyko rozwoju raka piersi w porównaniu do populacji ogólnej.1415 Ryzyko to dotyczy obu piersi, niezależnie od tego, w której wykryto LCIS, co sugeruje, że zmiana ta jest raczej markerem ryzyka niż bezpośrednim prekursorem inwazyjnego raka.16
U pacjentek z LCIS ryzyko rozwoju raka piersi (inwazyjnego lub DCIS) wynosi około 10% w ciągu 10 lat od diagnozy i wzrasta do około 20% po 20 latach.17 Absolutne ryzyko zachorowania na raka piersi po rozpoznaniu LCIS wynosi 20-25% po 20 latach obserwacji.18 W jednym z badań długoterminowych zaobserwowano roczną zachorowalność na raka piersi wynoszącą około 2% wśród kobiet z LCIS.1920
Warto podkreślić, że rozpoznanie LCIS nie oznacza, że pacjentka zachoruje na raka piersi – większość kobiet z tą zmianą nigdy nie rozwinie inwazyjnego nowotworu.21 Jednakże, ze względu na zwiększone ryzyko, regularne monitorowanie i rozważenie opcji zmniejszających ryzyko są kluczowymi elementami opieki nad pacjentką z LCIS.22
Diagnostyka LCIS
Diagnoza LCIS stawia przed personelem medycznym szczególne wyzwania, gdyż zmiana ta rzadko manifestuje się klinicznie i jest trudna do wykrycia w badaniach obrazowych.23
Metody diagnostyczne w wykrywaniu LCIS
Rozpoznanie LCIS opiera się głównie na badaniu histopatologicznym materiału uzyskanego podczas biopsji piersi:24
- Biopsja gruboigłowa – często wykonywaną pod kontrolą USG lub mammografii, pozwala na pobranie materiału do badania histopatologicznego
- Biopsja chirurgiczna (wycinająca) – wykonywana w przypadku niepewnego rozpoznania po biopsji gruboigłowej lub gdy wykryto pleomorficzny LCIS
- Badanie histopatologiczne – kluczowe dla postawienia rozpoznania LCIS, ocenia charakter komórek i ich ograniczenie do zrazików gruczołu piersiowego25
LCIS rzadko jest widoczny w badaniach obrazowych takich jak mammografia czy USG, co sprawia, że zwykle jest wykrywany przypadkowo podczas biopsji wykonywanej z innych powodów, np. w diagnostyce wyczuwalnego guzka piersi lub nieprawidłowego obrazu mammograficznego.2627
Opieka nad pacjentką z LCIS
Po rozpoznaniu LCIS konieczne jest opracowanie indywidualnego planu opieki, uwzględniającego preferencje pacjentki oraz dodatkowe czynniki ryzyka raka piersi.28 Postępowanie z pacjentkami z LCIS obejmuje kilka obszarów:
Aktywne monitorowanie
Regularne monitorowanie jest podstawą opieki nad pacjentką z LCIS i powinno obejmować:2930
- Badania kliniczne piersi co 6-12 miesięcy
- Coroczne badania mammograficzne
- W wybranych przypadkach rezonans magnetyczny (MRI) piersi
- Samokontrola piersi wykonywana przez pacjentkę co miesiąc31
Regularne badania kontrolne mają na celu wczesne wykrycie ewentualnych zmian, które mogłyby wskazywać na rozwój raka piersi. W przypadku zaobserwowania niepokojących objawów konieczna jest dalsza diagnostyka.32
Farmakoterapia zmniejszająca ryzyko (chemoprewencja)
Leki hormonalne mogą być stosowane w celu zmniejszenia ryzyka rozwoju raka piersi u pacjentek z LCIS. Do najczęściej stosowanych należą:3334
- Selektywne modulatory receptora estrogenowego (SERM):
- Tamoksyfen (Nolvadex, Soltamox) – może być stosowany zarówno u kobiet przed, jak i po menopauzie
- Raloksyfen (Evista) – zalecany głównie u kobiet po menopauzie
- Inhibitory aromatazy:
- Mogą być stosowane u kobiet po menopauzie do hamowania produkcji estrogenów
- Przykłady: anastrozol, letrozol, eksemestan35
Badania kliniczne wykazały, że zastosowanie tamoksyfenu u pacjentek z LCIS zmniejsza ryzyko rozwoju inwazyjnego raka piersi o około 56%.36 Decyzja o zastosowaniu hormonoterapii powinna być podjęta indywidualnie, po dokładnej ocenie potencjalnych korzyści i ryzyka związanego z leczeniem.37
Postępowanie chirurgiczne
Interwencja chirurgiczna w przypadku LCIS może obejmować różne procedury, w zależności od typu LCIS i indywidualnych czynników ryzyka:3839
- Lumpektomia – wycięcie zmiany wraz z marginesem zdrowej tkanki; zalecana głównie w przypadku pleomorficznego lub florydnego LCIS
- Biopsja wycinająca – wskazana w przypadku niezgodności między wynikiem biopsji gruboigłowej a obrazem klinicznym lub radiologicznym
- Profilaktyczna mastektomia obustronna – całkowite usunięcie obu piersi; rozważana u pacjentek z dodatkowymi czynnikami ryzyka, takimi jak silny wywiad rodzinny raka piersi lub mutacja genów BRCA1/BRCA24041
Należy podkreślić, że profilaktyczna mastektomia obustronna nie jest standardowym postępowaniem w przypadku LCIS i jest zarezerwowana dla wyselekcjonowanej grupy pacjentek z wysokim ryzykiem rozwoju raka piersi. Obecnie preferowane jest stosowanie leków zmniejszających ryzyko wraz z regularnym monitorowaniem.4243
Zalecenia pielęgnacyjne i wsparcie dla pacjentek z LCIS
Opieka nad pacjentką z LCIS powinna obejmować nie tylko aspekty medyczne, ale również działania wspierające i edukacyjne, mające na celu poprawę jakości życia i zmniejszenie niepokoju związanego z rozpoznaniem.44
Edukacja pacjentki
Kluczowym elementem opieki nad pacjentką z LCIS jest dostarczenie jej rzetelnych informacji na temat:45
- Natury LCIS jako czynnika ryzyka, a nie raka
- Rzeczywistego indywidualnego ryzyka rozwoju raka piersi
- Dostępnych opcji zapobiegawczych i ich skuteczności
- Znaczenia regularnych badań kontrolnych
- Technik samobadania piersi46
Wsparcie psychologiczne
Rozpoznanie LCIS może wywołać znaczny niepokój u pacjentek, związany z obawą przed rozwojem raka piersi. W ramach kompleksowej opieki należy zapewnić:4748
- Wsparcie psychologiczne, w tym dostęp do specjalistów w dziedzinie psychoonkologii
- Informacje o grupach wsparcia dla kobiet z podwyższonym ryzykiem raka piersi
- Pomoc w radzeniu sobie z lękiem i niepewnością
- Wsparcie w podejmowaniu decyzji dotyczących postępowania prewencyjnego49
Modyfikacja stylu życia
Pacjentkom z LCIS należy zalecać modyfikację stylu życia, która może pomóc w zmniejszeniu ryzyka rozwoju raka piersi:5051
- Regularna aktywność fizyczna (ćwiczenia co najmniej 150 minut tygodniowo)
- Utrzymanie prawidłowej masy ciała
- Ograniczenie spożycia alkoholu
- Zdrowa, zbilansowana dieta bogata w warzywa i owoce
- Unikanie palenia tytoniu52
Plan regularnych kontroli i badań
Po rozpoznaniu LCIS konieczne jest opracowanie indywidualnego planu badań kontrolnych, który powinien obejmować:5354
- Badanie kliniczne piersi przez lekarza co 6-12 miesięcy
- Mammografię wykonywaną co 12 miesięcy
- W wybranych przypadkach badanie MRI piersi (zwłaszcza u młodszych pacjentek lub z dodatkowymi czynnikami ryzyka)
- USG piersi jako badanie uzupełniające, zwłaszcza u kobiet z gęstą tkanką gruczołową piersi
- Regularne samobadanie piersi co miesiąc55
Plan badań kontrolnych powinien być kontynuowany przez całe życie pacjentki, ze względu na utrzymujące się zwiększone ryzyko rozwoju raka piersi.56 W przypadku pojawienia się niepokojących objawów, takich jak nowy guzek, zmiany w wyglądzie skóry piersi czy wydzielina z brodawki, pacjentka powinna niezwłocznie zgłosić się do lekarza.57
Kompleksowa opieka nad pacjentką z LCIS
Opieka nad pacjentką z rozpoznaniem LCIS wymaga kompleksowego podejścia, uwzględniającego zarówno aspekty medyczne, jak i psychospołeczne.58 Kluczowe elementy tej opieki obejmują:59
- Dokładne wyjaśnienie pacjentce natury LCIS i związanego z nim ryzyka
- Opracowanie indywidualnego planu monitorowania i badań kontrolnych
- Omówienie dostępnych opcji zmniejszających ryzyko rozwoju raka piersi, w tym farmakoterapii i potencjalnej interwencji chirurgicznej
- Wsparcie psychologiczne i edukacja w zakresie samobadania piersi
- Zachęcanie do modyfikacji stylu życia w celu zmniejszenia ryzyka raka piersi
- Regularne wizyty kontrolne i badania obrazowe60
Personel medyczny opiekujący się pacjentką z LCIS powinien dążyć do zindywidualizowanego podejścia, uwzględniającego jej preferencje, wartości i osobiste czynniki ryzyka. Współpraca w zespole interdyscyplinarnym, obejmującym lekarzy różnych specjalności, pielęgniarki, psychologów i dietetyków, pozwala na zapewnienie optymalnej opieki, mającej na celu zarówno zapobieganie rozwojowi raka piersi, jak i utrzymanie dobrej jakości życia pacjentki.6162
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Materiały źródłowe
- #1 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529
Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer. […] Your individual risk of breast cancer is based on many factors. Talk to your doctor to better understand your personal risk of breast cancer.
- #2 Lobular Carcinoma in Situ | LCIS | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html
Lobular carcinoma in situ (LCIS) is a type of breast change that is sometimes seen when a breast biopsy is done. In LCIS, cells that look like cancer cells are growing in the lining of the milk-producing glands (lobules) of the breast, but they dont invade through the wall of the lobules. […] LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn’t become invasive breast cancer) if it isnt treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. […] Women with LCIS have about a 7 to 12 times higher risk of developing invasive cancer in either breast. For this reason, doctors typically recommend that women with LCIS have regular breast cancer screening tests and follow-up visits with a health care provider for the rest of their lives.
- #3 Lobular Carcinoma in Situ (LCIS)https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis
Lobular carcinoma in situ (LCIS) is a rare breast condition. It causes abnormal cells in your lobules the glands in your breasts that produce breast milk. LCIS isnt breast cancer but it does increase the chance youll have breast cancer. Healthcare providers can treat the condition with medication. In some cases, they may recommend surgery. […] Having LCIS doesnt mean you have a serious illness. But a diagnosis of LCIS does increase the chance that youll develop breast cancer later on. […] Your treatment depends on the type of LCIS. For example, if you have classic LCIS, your healthcare provider may recommend active surveillance or preventive therapy. If you have pleomorphic or florid LCIS, you may need surgery. […] Active surveillance involves regular follow-up examinations and tests. For example, your healthcare provider may do a breast examination every six months. Theyll probably recommend that you have a mammogram every year. They may recommend additional tests, like a breast magnetic resonance imaging (MRI) scan.
- #4https://www.aurorahealthcare.org/services/cancer/breast-cancer/lobular-carcinoma-in-situ
Lobular carcinoma in situ (LCIS) is a non-cancerous condition where abnormal cells grow in the milk glands of your breast. While LCIS is not breast cancer, your risk of getting cancer increases if you’re diagnosed with it. […] If you’re diagnosed with LCIS, your Aurora cancer specialist may recommend more screenings and treatments to lower your risk of developing invasive breast cancer. […] Lobular carcinoma in situ (LCIS) is a non-invasive cancer that grows inside the milk glands (lobules) in the breast and hasn’t spread to nearby tissue. […] With LCIS, abnormal cells are found in the lobules of the breast. The term in situ means „in place,” so the abnormal cells do not penetrate the walls of the lobules or invade the surrounding breast tissue. […] LCIS is not considered cancer, but it does indicate a greater risk for developing breast cancer in the future. Yet, it doesn’t always lead to cancer itself.
- #5https://www.nhcs.com.sg/patient-care/conditions-treatments/lobular-carcinoma-in-situ
Lobular carcinoma in situ (LCIS) is caused by abnormal cells forming within the milk glands (lobules) in the breast. It is most common in women between the ages of 40 and 50. LCIS is not a cancer but it does increase the risk of developing breast cancer. […] Lobular carcinoma in situ (LCIS) is commonly an incidental finding on biopsy of the breast for another reason. […] Management of Lobular Carcinoma in Situ includes: Close observation e.g. clinical breast examinations, annual mammograms or MRI of the breasts. Chemoprevention, which is taking medication to reduce the risk of cancer. These drugs may include Tamoxifen or Raloxifene for 5 years. Surgery, where preventive or prophylactic mastectomy may be considered if there is a high risk based on a strong family history of breast cancer or if there is a BRCA gene mutation. […] There is an increase of 20 percent cancer risk over 15 years at the point of diagnosis.
- #6 Lobular Carcinoma In Situ LCIS | Tampa General Hospitalhttps://www.tgh.org/institutes-and-services/conditions/lobular-carcinoma-in-situ-lcis
Lobular carcinoma in situ (LCIS) is a relatively uncommon condition in which abnormal cells develop in the milk-producing glands (lobules) of a breast. Despite the word carcinoma in its name, LCIS is not a precancerous or cancerous condition. For this reason, it is no longer referred to as stage 0 breast cancer. […] Lobular carcinoma in situ does not produce noticeable symptoms or mammogram features. The unusual pattern of cell growth can only be seen during the microscopic evaluation of the breast tissue. In most cases, LCIS is an incidental finding in a breast biopsy performed for an unrelated reason, such as to evaluate a suspicious breast lump. […] After confirming a diagnosis of lobular carcinoma in situ, a physician may recommend more frequent breast cancer screenings, including clinical breast examinations and mammograms, and possibly prescribe a medication such as tamoxifen to help prevent the abnormal cells from transitioning into cancer. […] People who are diagnosed with lobular carcinoma in situ have a very good prognosis. With careful monitoring by an experienced physician and appropriate treatment when necessary, a patient with LCIS can remain healthy and cancer-free.
- #7 Lobular carcinoma in situ (LCIS) – Gynecological & Obstetrical Associateshttps://gynob.net/womens-health/health-library?DOCHWID=tv7534
Lobular carcinoma in situ (LCIS) is a type of abnormal cell change found in the milk glands (lobules) of the breast. LCIS is not cancer and the abnormal cells don’t spread beyond the lobules. But having LCIS makes you more likely to develop breast cancer later in life. […] LCIS usually doesn’t cause any symptoms or show up on a mammogram. In most cases, it’s found during a breast biopsy done for another problem.
- #8 Contemporary management of ductal carcinoma in situ and lobular carcinoma in situ – Obeng-Gyasi – Chinese Clinical Oncologyhttps://cco.amegroups.org/article/view/10361/html
Lobular carcinoma in situ (LCIS) is further subdivided into classic lobular carcinoma in situ (CLCIS) and pleomorphic lobular carcinoma in situ (PLCIS). […] LCIS confers a much higher risk (9-10 times increased risk) of breast cancer than atypical lobular hyperplasia (ALH) (4-5 times increased risk). […] The 2016 National Comprehensive Cancer Network (NCCN) guidelines for the management of LCIS recommend surgical excision for LCIS diagnosed on CNB. […] Multiple studies, including one prospective study, have recently reported low upgrade rates ranging from 1-5% upon exclusion of specimens with high risk characteristics such as non-classic morphology, discordant imaging and pathology, and extensive LCIS (4 foci). […] As indicated above, LCIS is considered both a high-risk lesion and a non-obligate precursor which confers a 10-20% risk for development of breast cancer.
- #9 Understanding Your Pathology Report: Lobular Carcinoma In Situ (LCIS) | American Cancer Societyhttps://www.cancer.org/cancer/diagnosis-staging/tests/biopsy-and-cytology-tests/understanding-your-pathology-report/breast-pathology/lobular-carcinoma-in-situ.html
Lobular carcinoma in situ (LCIS) is a type of in-situ carcinoma of the breast. While DCIS is considered a pre-cancer, it is unclear whether LCIS is a pre-cancer or if it’s just a general risk factor for developing breast cancer. This is because LCIS rarely seems to turn into invasive cancer if it’s left untreated. Having LCIS does increase a person’s risk of getting breast cancer, but the cancer occurs just as often in the opposite breast (the one without any LCIS). Because it isn’t clear if LCIS is a pre-cancer, many doctors prefer to use the term lobular neoplasia instead of lobular carcinoma in situ. […] For classic LCIS where there are no other concerning features, follow-up with breast exams and imaging tests (such as mammograms) might be all that is needed. […] Because LCIS increases a person’s risk of breast cancer later on, your doctor might talk to you about lifestyle changes and/or taking medicine to lower your risk of breast cancer.
- #10 Understanding Your Pathology Report: Lobular Carcinoma In Situ (LCIS) | American Cancer Societyhttps://www.cancer.org/cancer/diagnosis-staging/tests/biopsy-and-cytology-tests/understanding-your-pathology-report/breast-pathology/lobular-carcinoma-in-situ.html
If classic LCIS is found by an excisional biopsy, it typically does not need further treatment. However, with pleomorphic or florid LCIS, it’s important that the edges (margins) of the biopsy specimen don’t contain LCIS cells (which might mean that some were left behind). If they do, the doctor may recommend a more extensive surgery to make sure all of it was removed.
- #11 Lobular carcinoma in situ (LCIS) – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/diagnosis-treatment/drc-20374535
Surgery may be recommended in certain situations. For instance, surgery is often recommended for a specific type of LCIS called pleomorphic lobular carcinoma in situ (PLCIS). […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor.
- #12 Lobular Carcinoma in Situ (LCIS)https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis
As the name implies, preventive therapy is a treatment intended to keep abnormal cells in your lobules from becoming cancerous cells. […] If tests show you have pleomorphic or florid LCIS, your oncologist may recommend breast cancer surgery, including: Lumpectomy: This surgery removes abnormal cells and a small amount of healthy breast tissue. Prophylactic bilateral mastectomy: This surgery removes both of your breasts. Your provider may recommend mastectomy if an immediate family member, such as your mother, daughter or sister, had or has breast cancer. […] That depends on your situation, including the type of LCIS that you have. If you wonder what to expect, ask your healthcare provider to explain whats going on in your breast and your treatment options. Understanding your options will help you feel more confident about your plan for living with LCIS.
- #13 Lobular carcinoma in situ (LCIS) | Cancer Research UKhttps://www.cancerresearchuk.org/about-cancer/breast-cancer/types/lobular-carcinoma-in-situ-lcis
Your doctor may suggest taking hormone therapy for 5 years to lower your risk of developing invasive breast cancer. […] You are more likely to have surgery rather than monitoring if you have a particular type of LCIS called pleomorphic LCIS or florid LCIS. […] Rarely you have surgery to remove your breast (a mastectomy). You might have this if the changes are widespread throughout the breast. […] Research has focused on trying to find genetic changes that might increase the risk of developing LCIS. […] Researchers are also looking into using different types of hormone therapy to prevent invasive breast cancer after a diagnosis of LCIS.
- #14 Lobular Carcinoma in Situ | LCIS | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html
Lobular carcinoma in situ (LCIS) is a type of breast change that is sometimes seen when a breast biopsy is done. In LCIS, cells that look like cancer cells are growing in the lining of the milk-producing glands (lobules) of the breast, but they dont invade through the wall of the lobules. […] LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn’t become invasive breast cancer) if it isnt treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. […] Women with LCIS have about a 7 to 12 times higher risk of developing invasive cancer in either breast. For this reason, doctors typically recommend that women with LCIS have regular breast cancer screening tests and follow-up visits with a health care provider for the rest of their lives.
- #15 Lobular Carcinoma in Situ (LCIS) | Susan G. Komen®https://www.komen.org/breast-cancer/risk-factor/lobular-carcinoma-in-situ/
When abnormal cells grow inside the breast lobules, but have not spread to nearby tissue or beyond, the condition is called lobular carcinoma in situ (LCIS). […] Although the term LCIS includes the word carcinoma, LCIS is not cancer. […] Women with LCIS have an increased risk of invasive breast cancer. […] Compared to women without LCIS, those with LCIS are 7-11 times more likely to develop invasive cancer in either breast (the breast with LCIS or the opposite breast). […] Women diagnosed with LCIS have about a 10% chance of developing ductal carcinoma in situ (DCIS) or invasive breast cancer in 10 years. […] Women with LCIS can develop invasive lobular cancer or invasive ductal cancer. […] In the past, LCIS was not considered to be a precursor (a condition that can develop into) to breast cancer. However, some studies show LCIS may develop into invasive lobular cancer (invasive breast cancer that begins in the lobules).
- #16 Lobular carcinoma | Canadian Cancer Societyhttps://cancer.ca/en/cancer-information/cancer-types/breast/what-is-breast-cancer/cancerous-tumours/lobular-carcinoma
Lobular carcinoma starts in the groups of glands that make milk (called lobules). It may be non-invasive (called lobular carcinoma in situ) or invasive. […] LCIS is a buildup of abnormal cells in the lobules. These cells do not spread outside the lobules into nearby breast tissue. LCIS often develops in many different parts of the breast at the same time. It often develops in both breasts at the same time. […] LCIS is neither a true precancerous condition nor breast cancer. It is a sign, or marker, that a woman is at a higher risk of developing breast cancer in the future. Many women with LCIS do not develop invasive breast cancer. […] Because of this increased risk, it is very important for women with LCIS to be screened for breast cancer. […] If you are diagnosed with LCIS, talk to your doctor about a personal plan for screening for breast cancer. This plan may include having mammography more often. You may also want to talk with your doctor about a treatment plan. You may be offered hormonal therapy with tamoxifen (Nolvadex, Tamofen). Some women may consider having surgery to remove the breasts (called a prophylactic mastectomy) if they have other risk factors for breast cancer as well as LCIS.
- #17 Lobular Carcinoma In-Situ (LCIS)https://cbcn.ca/en/lobular-carcinoma-in-situ
Lobular carcinoma in situ (LCIS) describes a condition in which there is abnormal cell growth in the lining on the lobules that dont invade the wall of the lobules. […] While LCIS is a benign condition and is not considered to be breast cancer, having LCIS puts a person at an approximately 7 to 12 times higher risk of later developing invasive breast cancer. […] For women diagnosed with LCIS, the risk of developing breast cancer in 10 years is 10% and after 20 years of an LCIS diagnosis, the risk is 20%. […] If you have been diagnosed with LCIS, there is no action that you need to take since it is not cancer. However, there are a few options available to you to manage your increased risk of breast cancer. […] Options following a diagnosis of LCIS include: […] Close monitoring and increased surveillance: After being diagnosed with LCIS, you might take a wait and see approach.
- #18 Lobular Carcinoma in Situ of the Breast | Oncohema Keyhttps://oncohemakey.com/lobular-carcinoma-in-situ-of-the-breast/
LCIS is commonly widespread in the breast, with patterns that are multifocal, multicentric, and/or bilateral. […] Women diagnosed with LCIS are typically quoted to have an 8- to 10-fold increased lifetime risk for developing breast cancer in both the ipsilateral and the contralateral breast. […] The absolute risk of breast cancer after LCIS is 20% to 25% after 20 years. […] Chemoprevention was the only factor found on multivariate analysis to influence breast cancer risk, substantially decreasing it. […] On average, they found a 2% annual incidence of breast cancer development in the setting of a prior diagnosis of LCIS. […] It is possible that some subgroups of LCIS may exhibit a more aggressive unilateral biology and preinvasive behavior. […] The extent of LCIS (few lobules vs. extensive disease) and subtyping based on classic versus pleomorphic histopathology has not always been a standard part of pathology reports.
- #19 Treatment and survival outcomes of lobular carcinoma in situ of the breast: a SEER population based studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5732709/
Lobular carcinoma in situ (LCIS) represents 5.3% of in situ specimens, and is thought to carry a low risk for developing to the invasive lobular breast cancer (ILC). There is still no standard care approach for patients with LCIS. […] At present, there is no standardized treatment for LCIS. NCCN guidelines 2017 pointed out that surgical removal was suggested once LCIS was diagnosed via CNB. […] Great debate has hitherto existed on the treatment options of women diagnosed with LCIS. In the present study, impacts of various factors on survival outcomes for women with LCIS were analyzed using population-based data from the National Cancer Institutes Surveillance, Epidemiology, and End Results (SEER) database. […] In our study, both UVA and MVA results indicated that patients underwent LA and LRT had better survival compared to those who accepted other treatments. […] Considering the medical expense and the risk of radiotherapy, we think LA may be the most appropriate option for patients with LCIS.
- #20 Lobular Carcinoma in Situ: A 29-Year Longitudinal Experience Evaluating Clinicopathologic Features and Breast Cancer Risk – PubMedhttps://pubmed.ncbi.nlm.nih.gov/26371145/
Purpose: The increased breast cancer risk conferred by a diagnosis of lobular carcinoma in situ (LCIS) is poorly understood. Here, we review our 29-year longitudinal experience with LCIS to evaluate factors associated with breast cancer risk. […] Conclusion: We observed a 2% annual incidence of breast cancer among women with LCIS. Common clinical factors used for risk prediction, including age and family history, were not associated with breast cancer risk. The lower breast cancer incidence in women opting for chemoprevention highlights the potential for risk reduction in this population.
- #21https://step2.medbullets.com/oncology/120424/lobular-carcinoma-in-situ-lcis
tamoxifen […] higher-risk patients to reduce future invasive carcinoma risk […] close follow-up […] frequent scheduled exams […] mammographic screening of both breasts. […] excisional biopsy […] high-risk patients […] bilateral mastectomy […] to reduce risk of developing invasive carcinoma in ipsilateral or contralateral breast […] in patients who have family history of premenopausal breast carcinoma. […] Development of invasive carcinoma. […] majority of women with LCIS will not develop invasive breast cancer.
- #22 Understanding lobular carcinoma in situ (LCIS) | Macmillan Cancer Supporthttps://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/pre-cancerous-and-genetic-conditions/lobular-carcinoma-in-situ
Doctors usually recommend having mammograms every 1 to 2 years. Some people may also be offered MRI scans. This is called monitoring. […] Hormonal therapy is usually given to people who have had treatment for breast cancer. It aims to reduce the risk of cancer coming back. If you have LCIS, you may be offered hormonal therapy drugs to reduce the risk of breast cancer developing. […] If you are diagnosed with LCIS, your doctor or nurse will ask about your general health and your family history. This is to find out whether there is a pattern of breast cancer in your family. […] Some women who are assessed as having a high risk of breast cancer, may think about having surgery to remove both breasts removed. This is to reduce the risk of breast cancer developing. It is called risk-reducing breast surgery. It is important to talk to your doctor about the potential risks and benefits before making a decision. […] It is natural to feel worried if you know you have an increased risk of breast cancer. But LCIS is not cancer, and most people with LCIS do not develop breast cancer.
- #23 Lobular Carcinoma In Situ LCIS | Tampa General Hospitalhttps://www.tgh.org/institutes-and-services/conditions/lobular-carcinoma-in-situ-lcis
Lobular carcinoma in situ (LCIS) is a relatively uncommon condition in which abnormal cells develop in the milk-producing glands (lobules) of a breast. Despite the word carcinoma in its name, LCIS is not a precancerous or cancerous condition. For this reason, it is no longer referred to as stage 0 breast cancer. […] Lobular carcinoma in situ does not produce noticeable symptoms or mammogram features. The unusual pattern of cell growth can only be seen during the microscopic evaluation of the breast tissue. In most cases, LCIS is an incidental finding in a breast biopsy performed for an unrelated reason, such as to evaluate a suspicious breast lump. […] After confirming a diagnosis of lobular carcinoma in situ, a physician may recommend more frequent breast cancer screenings, including clinical breast examinations and mammograms, and possibly prescribe a medication such as tamoxifen to help prevent the abnormal cells from transitioning into cancer. […] People who are diagnosed with lobular carcinoma in situ have a very good prognosis. With careful monitoring by an experienced physician and appropriate treatment when necessary, a patient with LCIS can remain healthy and cancer-free.
- #24 Lobular carcinoma in situ (LCIS) – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/diagnosis-treatment/drc-20374535
Lobular carcinoma in situ (LCIS) may be present in one or both breasts, but it usually isn’t visible on a mammogram. The condition is most often diagnosed as an incidental finding when you have a biopsy done to evaluate some other area of concern in your breast. […] The tissue removed during your biopsy is sent to a laboratory where doctors that specialize in analyzing blood and body tissues (pathologists) closely examine the cells to determine if you have Lobular carcinoma in situ (LCIS). […] A number of factors, including your personal preferences, come into play when you decide whether to undergo treatment for lobular carcinoma in situ (LCIS). […] If you’ve been diagnosed with LCIS, your doctor may recommend more frequent exams to closely monitor your breasts for signs of cancer. […] Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer.
- #25 Lobular carcinoma in situ (LCIS) – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/diagnosis-treatment/drc-20374535
Lobular carcinoma in situ (LCIS) may be present in one or both breasts, but it usually isn’t visible on a mammogram. The condition is most often diagnosed as an incidental finding when you have a biopsy done to evaluate some other area of concern in your breast. […] The tissue removed during your biopsy is sent to a laboratory where doctors that specialize in analyzing blood and body tissues (pathologists) closely examine the cells to determine if you have Lobular carcinoma in situ (LCIS). […] A number of factors, including your personal preferences, come into play when you decide whether to undergo treatment for lobular carcinoma in situ (LCIS). […] If you’ve been diagnosed with LCIS, your doctor may recommend more frequent exams to closely monitor your breasts for signs of cancer. […] Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer.
- #26 Lobular Carcinoma In Situ LCIS | Tampa General Hospitalhttps://www.tgh.org/institutes-and-services/conditions/lobular-carcinoma-in-situ-lcis
Lobular carcinoma in situ (LCIS) is a relatively uncommon condition in which abnormal cells develop in the milk-producing glands (lobules) of a breast. Despite the word carcinoma in its name, LCIS is not a precancerous or cancerous condition. For this reason, it is no longer referred to as stage 0 breast cancer. […] Lobular carcinoma in situ does not produce noticeable symptoms or mammogram features. The unusual pattern of cell growth can only be seen during the microscopic evaluation of the breast tissue. In most cases, LCIS is an incidental finding in a breast biopsy performed for an unrelated reason, such as to evaluate a suspicious breast lump. […] After confirming a diagnosis of lobular carcinoma in situ, a physician may recommend more frequent breast cancer screenings, including clinical breast examinations and mammograms, and possibly prescribe a medication such as tamoxifen to help prevent the abnormal cells from transitioning into cancer. […] People who are diagnosed with lobular carcinoma in situ have a very good prognosis. With careful monitoring by an experienced physician and appropriate treatment when necessary, a patient with LCIS can remain healthy and cancer-free.
- #27 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529
Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer. […] Your individual risk of breast cancer is based on many factors. Talk to your doctor to better understand your personal risk of breast cancer.
- #28https://www.aurorahealthcare.org/services/cancer/breast-cancer/lobular-carcinoma-in-situ
Regular monitoring and follow-up care are crucial if you have LCIS so any signs of progression or development of invasive cancer can be detected early. This typically involves regular breast exams, mammograms and sometimes additional imaging or biopsies. […] Your personalized treatment plan for LCIS will vary depending on factors such as your overall health, preferences and risk factors. […] The following treatments are commonly used for LCIS: Observation: Your doctor will recommend more regular checkups and monthly self-exams. They may also suggest annual mammograms to check for any changes in the breast tissue. […] Preventive mastectomy: Includes the removal of one or both breasts to reduce the risk of developing invasive breast cancer. […] Risk-reducing medications: Selective estrogen receptor modulators or aromatase inhibitors may be prescribed to block estrogen receptors in the breasts. This helps reduce your risk of developing invasive breast cancer.
- #29 Lobular Carcinoma in Situ (LCIS)https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis
Lobular carcinoma in situ (LCIS) is a rare breast condition. It causes abnormal cells in your lobules the glands in your breasts that produce breast milk. LCIS isnt breast cancer but it does increase the chance youll have breast cancer. Healthcare providers can treat the condition with medication. In some cases, they may recommend surgery. […] Having LCIS doesnt mean you have a serious illness. But a diagnosis of LCIS does increase the chance that youll develop breast cancer later on. […] Your treatment depends on the type of LCIS. For example, if you have classic LCIS, your healthcare provider may recommend active surveillance or preventive therapy. If you have pleomorphic or florid LCIS, you may need surgery. […] Active surveillance involves regular follow-up examinations and tests. For example, your healthcare provider may do a breast examination every six months. Theyll probably recommend that you have a mammogram every year. They may recommend additional tests, like a breast magnetic resonance imaging (MRI) scan.
- #30https://www.aurorahealthcare.org/services/cancer/breast-cancer/lobular-carcinoma-in-situ
Regular monitoring and follow-up care are crucial if you have LCIS so any signs of progression or development of invasive cancer can be detected early. This typically involves regular breast exams, mammograms and sometimes additional imaging or biopsies. […] Your personalized treatment plan for LCIS will vary depending on factors such as your overall health, preferences and risk factors. […] The following treatments are commonly used for LCIS: Observation: Your doctor will recommend more regular checkups and monthly self-exams. They may also suggest annual mammograms to check for any changes in the breast tissue. […] Preventive mastectomy: Includes the removal of one or both breasts to reduce the risk of developing invasive breast cancer. […] Risk-reducing medications: Selective estrogen receptor modulators or aromatase inhibitors may be prescribed to block estrogen receptors in the breasts. This helps reduce your risk of developing invasive breast cancer.
- #31https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/lobular-carcinoma-in-situ
Observation: Since LCIS is noncancerous, regular checkups and monthly self-exams are the most used treatment option. Your doctor may also suggest annual mammograms to check for any changes in the breast tissue. […] Preventive mastectomy: The removal of one or both breasts to reduce the risk of developing invasive breast cancer. Skin-sparing and nipple-sparing mastectomies may be offered, depending on the proximity of the LCIS to those structures. […] Surgical treatments: A lumpectomy may be an option, where your surgeon removes any cancerous and abnormal tissue, some healthy tissue and lymph nodes under the arm. After surgery, your doctor will deliver radiation therapy into an open incision.
- #32 Recommendations for Women With Lobular Carcinoma In Situ (LCIS)https://www.cancernetwork.com/view/recommendations-women-lobular-carcinoma-situ-lcis
This article will review current management trends for women with classical lobular carcinoma in situ (LCIS). […] Today, a diagnosis of LCIS remains one of the greatest identifiable risk factors for the subsequent development of breast cancer. As such, patients are offered one of three options: (1) lifelong surveillance with the goal of detecting subsequent malignancy at an early stage; (2) chemoprevention; or (3) bilateral prophylactic mastectomy. […] A diagnosis of LCIS is one of the greatest identifiable risk factors for the subsequent development of breast cancer. Compared to the general population, women with LCIS have an eight-fold to ten-fold increased risk of breast cancer. […] Surveillance is the minimum necessary action for women in whom LCIS is diagnosed. Recommendations from the NCCN Breast Cancer Screening and Diagnosis Clinical Practice Guidelines include annual mammography and clinical breast exam every 6 to 12 months.
- #33 Lobular Carcinoma in Situ (LCIS) | Memorial Sloan Kettering Cancer Centerhttps://www.mskcc.org/cancer-care/patient-education/lobular-carcinoma-situ-lcis
LCIS is a condition where there is an overgrowth of cells in the ducts or lobules. […] LCIS isnt breast cancer, but it can raise your risk of getting breast cancer. […] People with LCIS should have regular breast exams and breast imaging because of their higher breast cancer risk. […] Taking certain medications can help lower your risk of getting breast cancer. […] Tamoxifen (Nolvadex, Soltamox) and raloxifene (Evista) are medications that lower your risk for breast cancer. […] Aromatase inhibitors are medications that stop an enzyme called aromatase from changing other hormones into estrogen. […] Some people may choose to have their breasts removed to prevent breast cancer. This is called a bilateral prophylactic (PRO-fih-LAK-tik) mastectomy. […] There are also lifestyle changes you can make to lower your breast cancer risk if you have LCIS.
- #34 Lobular Carcinoma in Situ (LCIS) | Susan G. Komen®https://www.komen.org/breast-cancer/risk-factor/lobular-carcinoma-in-situ/
The National Comprehensive Cancer Network (NCCN) strongly recommends women with LCIS take a risk-reducing drug (such as tamoxifen) to lower their risk of breast cancer. […] Today, the use of a risk-reducing drug (along with recommended breast cancer screening to find breast cancer early if it develops) is the preferred option over risk-reducing mastectomy for lowering risk in women with LCIS. […] In the past, risk-reducing bilateral mastectomy (surgery to remove both breasts) was considered for women with LCIS to lower breast cancer risk as much as possible. This is now discouraged since the risk reduction benefits from a risk-reducing drug and surgery are similar.
- #35 Lobular Carcinoma In-Situ (LCIS)https://cbcn.ca/en/lobular-carcinoma-in-situ
Chemoprevention and aromatase inhibitors: Estrogen is a natural hormone in the body that has been found to increase the risk of developing breast cancer and making breast tumors grow. […] Additionally, aromatase inhibitors, which stops the enzyme aromatase from changing other hormones into estrogen, may also be used by post-menopausal women to reduce their risk of developing breast cancer following a diagnosis of LCIS. […] Surgery: The risks and benefits of having surgery to treat LCIS must be taken into consideration since an LCIS diagnosis is not guaranteed to become a breast cancer diagnosis. […] Surgical options for treating LCIS include: […] Ultrasound-guided, vacuum-assisted excision A fairly non-invasive method that removes the abnormal areas of the breast tissue. […] Lumpectomy Involves removing the abnormal areas of the breast tissue along with parts of the surrounding tissue. […] Prophylactic mastectomy The removal of the entire breast tissue in one or both breasts.
- #36 Lobular Carcinoma in Situ – Virginia Cancer Institutehttps://www.vacancer.com/cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ/
Patients who choose observation require yearly examinations and follow-up biopsies as indicated. […] Because of the observation that women with breast cancer treated with Nolvadex had a lower risk of developing a new breast cancer in their unaffected breast, many doctors felt that Nolvadex may actually be able to prevent breast cancer from occurring. […] In patients with LCIS, the incidence of invasive breast cancer was reduced 56% by the administration of Nolvadex. […] All patients with LCIS may want to consider treatment intervention with Nolvadex or other anti-estrogens. […] A bilateral prophylactic mastectomy involves the preventive removal of both breasts. This is an effective method of preventing invasive breast cancer in patients with LCIS.
- #37 Mayo Clinic Health Library – Lobular carcinoma in situ (LCIS) | Swiss Medical Networkhttps://www.swissmedical.net/en/healtcare-library/con-20374514
A number of factors, including your personal preferences, come into play when you decide whether to undergo treatment for lobular carcinoma in situ (LCIS). […] If you’ve been diagnosed with LCIS, your doctor may recommend more frequent exams to closely monitor your breasts for signs of cancer. […] Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer. […] Discuss with your doctor the risks and benefits of taking a drug for breast cancer prevention to see if it’s the best course of treatment for you. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer.
- #38 Lobular carcinoma in situ (LCIS) – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/diagnosis-treatment/drc-20374535
Surgery may be recommended in certain situations. For instance, surgery is often recommended for a specific type of LCIS called pleomorphic lobular carcinoma in situ (PLCIS). […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor.
- #39 Lobular Carcinoma in Situ (LCIS)https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis
As the name implies, preventive therapy is a treatment intended to keep abnormal cells in your lobules from becoming cancerous cells. […] If tests show you have pleomorphic or florid LCIS, your oncologist may recommend breast cancer surgery, including: Lumpectomy: This surgery removes abnormal cells and a small amount of healthy breast tissue. Prophylactic bilateral mastectomy: This surgery removes both of your breasts. Your provider may recommend mastectomy if an immediate family member, such as your mother, daughter or sister, had or has breast cancer. […] That depends on your situation, including the type of LCIS that you have. If you wonder what to expect, ask your healthcare provider to explain whats going on in your breast and your treatment options. Understanding your options will help you feel more confident about your plan for living with LCIS.
- #40https://www.iowaclinic.com/specialties/surgery/general-surgery/breast-surgery/lcis/
Risk-Reducing Surgery: In some cases, women with LCIS may choose to undergo risk-reducing surgery, such as bilateral prophylactic mastectomy, to reduce their risk of developing invasive breast cancer. […] It is essential to seek regular monitoring and follow-up care to detect any changes or signs of progression to invasive disease.
- #41 Lobular carcinoma in situ (LCIS) | Cancer Research UKhttps://www.cancerresearchuk.org/about-cancer/breast-cancer/types/lobular-carcinoma-in-situ-lcis
Your doctor may suggest taking hormone therapy for 5 years to lower your risk of developing invasive breast cancer. […] You are more likely to have surgery rather than monitoring if you have a particular type of LCIS called pleomorphic LCIS or florid LCIS. […] Rarely you have surgery to remove your breast (a mastectomy). You might have this if the changes are widespread throughout the breast. […] Research has focused on trying to find genetic changes that might increase the risk of developing LCIS. […] Researchers are also looking into using different types of hormone therapy to prevent invasive breast cancer after a diagnosis of LCIS.
- #42 Lobular Carcinoma in Situ (LCIS) | Susan G. Komen®https://www.komen.org/breast-cancer/risk-factor/lobular-carcinoma-in-situ/
The National Comprehensive Cancer Network (NCCN) strongly recommends women with LCIS take a risk-reducing drug (such as tamoxifen) to lower their risk of breast cancer. […] Today, the use of a risk-reducing drug (along with recommended breast cancer screening to find breast cancer early if it develops) is the preferred option over risk-reducing mastectomy for lowering risk in women with LCIS. […] In the past, risk-reducing bilateral mastectomy (surgery to remove both breasts) was considered for women with LCIS to lower breast cancer risk as much as possible. This is now discouraged since the risk reduction benefits from a risk-reducing drug and surgery are similar.
- #43 Get Lobular Carcinoma in Situ Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/lobular-carcinoma-situ-treatment
Our breast health experts may recommend a couple of different ways to manage lobular carcinoma in situ. […] This is a fancy way of saying well keep a close eye on whats going on to make sure nothing changes. […] Medications like selective estrogen receptor modulators (SERMs), such as tamoxifen (Nolvadex or Soltamox) or raloxifene (Evista), can lower your risk of developing estrogen-sensitive breast cancer the most common type. […] Its important to note that risk-reducing surgery (preventive mastectomy) is no longer the treatment of choice for LCIS, since preventive medications are so effective. […] Our expert breast health providers include psychologists who specialize in helping people with breast conditions. […] From the moment youre diagnosed, to learning how to manage your LCIS, to navigating follow-up care, were here for you every step of the way.
- #44 Get Lobular Carcinoma in Situ Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/lobular-carcinoma-situ-treatment
You just found out you may have lobular carcinoma in situ. And now you’re worried. Isnt that breast cancer? […] No, but its a red flag. It means you have abnormal cells in your breasts milk glands (lobules). The cells arent spreading or multiplying yet. Theyre in situ, which means theyre staying put for now. But having them means youre at a higher risk of developing breast cancer than people who dont. […] Our team of breast health experts will help you keep an eye on whats happening and manage your condition to lower your risk of getting breast cancer down the road. […] At Cleveland Clinic, we focus on not just your physical health, but also on your emotional well-being. […] Our compassionate breast cancer team will be by your side providing expertise and support as you walk this uncertain path.
- #45 Lobular carcinoma in situ (LCIS) | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/lobular-carcinoma-in-situ-lcis?content_id=CON-20374514
Discuss with your doctor the risks and benefits of taking a drug for breast cancer prevention to see if it’s the best course of treatment for you. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. […] These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer? […] Am I a candidate for preventive surgery?
- #46 Lobular carcinoma in situ (LCIS) | Altru Health Systemhttps://www.altru.org/health-library/conditions/lobular-carcinoma-in-situ-lcis
Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer?
- #47 Lobular carcinoma in situ (LCIS) – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/diagnosis-treatment/drc-20374535
Surgery may be recommended in certain situations. For instance, surgery is often recommended for a specific type of LCIS called pleomorphic lobular carcinoma in situ (PLCIS). […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor.
- #48 Get Lobular Carcinoma in Situ Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/lobular-carcinoma-situ-treatment
Our breast health experts may recommend a couple of different ways to manage lobular carcinoma in situ. […] This is a fancy way of saying well keep a close eye on whats going on to make sure nothing changes. […] Medications like selective estrogen receptor modulators (SERMs), such as tamoxifen (Nolvadex or Soltamox) or raloxifene (Evista), can lower your risk of developing estrogen-sensitive breast cancer the most common type. […] Its important to note that risk-reducing surgery (preventive mastectomy) is no longer the treatment of choice for LCIS, since preventive medications are so effective. […] Our expert breast health providers include psychologists who specialize in helping people with breast conditions. […] From the moment youre diagnosed, to learning how to manage your LCIS, to navigating follow-up care, were here for you every step of the way.
- #49 Mayo Clinic Health Library – Lobular carcinoma in situ (LCIS) | Swiss Medical Networkhttps://www.swissmedical.net/en/healtcare-library/con-20374514
If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor.
- #50 Lobular Carcinoma in Situ (LCIS)https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis
Theres a lot you can do to take care of yourself if you have LCIS, like eating well, getting regular exercise and avoiding beverages that contain alcohol. […] Lobular carcinoma in situ is a rare condition that increases your risk of developing breast cancer. Understanding your risk and your options can help you feel more confident and in control of your situation. […] Receiving an LCIS diagnosis doesnt mean youll develop breast cancer. But it does mean youre at risk for developing the condition. To be clear, theres a 1 in 10 chance that will happen. If you have this condition, it may help to know about treatments that can reduce or eliminate your risk. And there are things you can do on your own. If tests show you have LCIS, your healthcare provider will take the time to explain your options and recommend programs and services. […] Lobular carcinoma in situ means you have a higher risk of developing breast cancer. Cleveland Clinics experts can help manage your risk with personalized care.
- #51 Lobular carcinoma in situ (LCIS) | Altru Health Systemhttps://www.altru.org/health-library/conditions/lobular-carcinoma-in-situ-lcis
Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer?
- #52 Lobular carcinoma in situ (LCIS) | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/lobular-carcinoma-in-situ-lcis?content_id=CON-20374514
Discuss with your doctor the risks and benefits of taking a drug for breast cancer prevention to see if it’s the best course of treatment for you. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. […] These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer? […] Am I a candidate for preventive surgery?
- #53 Treatment options for lobular carcinoma in situ | Cancer Australiahttps://www.canceraustralia.gov.au/cancer-types/breast-cancer/treatment-options/treatment-options-lobular-carcinoma-situ
Lobular carcinoma in situ (LCIS) is the name for abnormal cells that are contained in the lobules of the breast. The causes of LCIS are unknown. […] In LCIS, the abnormal cells stay inside the lobules of the breast and do not spread to other parts of the breast or body. A woman cannot die from having only LCIS. […] LCIS cannot usually be felt as a breast lump or other breast change. Changes due to LCIS only sometimes show up on a mammogram. Most cases of LCIS are found when a woman has a biopsy for another reason. Most women are not aware of any symptoms at the time of diagnosis. […] LCIS is not the same as invasive breast cancer. LCIS does not need to be treated if there are no other abnormal changes to the breast. However, having LCIS increases the risk of developing breast cancer. […] If a woman has LCIS, itâs important that she has regular check-ups, including: a physical examination of both breasts by a doctor once a year, a mammogram/ultrasound of both breasts once a year.
- #54 Understanding lobular carcinoma in situ (LCIS) | Macmillan Cancer Supporthttps://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/pre-cancerous-and-genetic-conditions/lobular-carcinoma-in-situ
Lobular carcinoma in situ (LCIS) is not a cancer. But it can increase the risk of developing cancer. […] If you have LCIS, you will not need any treatment. LCIS usually does not cause any problems. Most people with LCIS do not develop breast cancer, so they never need treatment. You will be offered regular monitoring. This is to make sure that if a cancer develops, it is found early. […] If you develop breast cancer, you can start treatment straight away. Treatment for early breast cancer is usually very successful. Your specialist doctor and nurse will explain what happens after treatment (your follow-up). […] There is a rare type of LCIS called pleomorphic LCIS. It is usually treated in a similar way to ductal carcinoma in situ (DCIS). If you are diagnosed with this type of LCIS, your doctor or nurse will explain more about it.
- #55https://www.cancervic.org.au/cancer-information/screening/breasts-health/lobular-carcinoma-in-situ
Lobular carcinoma in situ (LCIS) is an uncommon condition where benign (non-cancer) change is seen within the lobules of the breast. […] Although the term 'carcinoma in situ’ can arouse anxiety and thoughts of cancer, LCIS is considered a benign condition that doesn’t usually require treatment. […] However, long-term follow-up is recommended after a diagnosis of LCIS. […] LCIS is not invasive breast cancer. However, research has shown that some women diagnosed with LCIS may later develop breast cancer, which can occur in either breast, sometimes many years later. […] If breast cancer does occur after a diagnosis of LCIS, it can be either ductal or lobular cancer. […] For this reason, your doctor will advise you about regular, long-term follow-up. […] Usually this will mean annual mammograms as well as regular breast checks by a doctor. […] Women with a diagnosis of LCIS may think about taking hormone replacement therapy (HRT) if they’re troubled by symptoms arising from menopause. […] If you’re considering taking HRT, discuss your situation with your doctor.
- #56 Lobular Carcinoma in Situ | LCIS | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html
Having LCIS does increase your risk of developing invasive breast cancer later on. But since LCIS is not a true cancer or pre-cancer, often no treatment is needed after the biopsy. […] Close follow-up is important because women with LCIS have the same increased risk of developing cancer in both breasts. Women should also talk to a health care provider about what they can do to help reduce their breast cancer risk. Options for women at high risk of breast cancer because of LCIS may include: […] Surgery, called bilateral prophylactic mastectomy (removal of both breasts), to reduce risk.
- #57https://www.kuh.ku.edu.tr/mayo-clinic-care-network/mayo-clinic-health-information-library/diseases-conditions/lobular-carcinoma-in-situ-lcis
Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. Coping with your diagnosis means finding a long-term way to manage your fear and uncertainty. […] Make an appointment with your doctor if you notice a lump or any other unusual change in your breasts.
- #58 Get Lobular Carcinoma in Situ Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/lobular-carcinoma-situ-treatment
You just found out you may have lobular carcinoma in situ. And now you’re worried. Isnt that breast cancer? […] No, but its a red flag. It means you have abnormal cells in your breasts milk glands (lobules). The cells arent spreading or multiplying yet. Theyre in situ, which means theyre staying put for now. But having them means youre at a higher risk of developing breast cancer than people who dont. […] Our team of breast health experts will help you keep an eye on whats happening and manage your condition to lower your risk of getting breast cancer down the road. […] At Cleveland Clinic, we focus on not just your physical health, but also on your emotional well-being. […] Our compassionate breast cancer team will be by your side providing expertise and support as you walk this uncertain path.
- #59 Lobular carcinoma in situ (LCIS) | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/lobular-carcinoma-in-situ-lcis?content_id=CON-20374514
Discuss with your doctor the risks and benefits of taking a drug for breast cancer prevention to see if it’s the best course of treatment for you. […] Surgery may be recommended in certain situations. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer. […] If you’re worried about your risk of breast cancer, take steps to reduce your risk, such as: Exercise most days of the week. […] Although LCIS is not cancer, it can make you worry about your increased risk of a future breast cancer. […] These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer? […] Am I a candidate for preventive surgery?
- #60 Lobular carcinoma in situ (LCIS)https://www.mymlc.com/health-information/diseases-and-conditions/l/lobular-carcinoma-in-situ-lcis2/?section=Causes
These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] Make an appointment with your doctor if you notice a lump or any other unusual change in your breasts. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor.
- #61 Get Lobular Carcinoma in Situ Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/lobular-carcinoma-situ-treatment
Our breast health experts may recommend a couple of different ways to manage lobular carcinoma in situ. […] This is a fancy way of saying well keep a close eye on whats going on to make sure nothing changes. […] Medications like selective estrogen receptor modulators (SERMs), such as tamoxifen (Nolvadex or Soltamox) or raloxifene (Evista), can lower your risk of developing estrogen-sensitive breast cancer the most common type. […] Its important to note that risk-reducing surgery (preventive mastectomy) is no longer the treatment of choice for LCIS, since preventive medications are so effective. […] Our expert breast health providers include psychologists who specialize in helping people with breast conditions. […] From the moment youre diagnosed, to learning how to manage your LCIS, to navigating follow-up care, were here for you every step of the way.
- #62 Lobular carcinoma in situ (LCIS) – Augusta HealthSearchClose SearchSearch IconSearch IconClose Search IconMobile Menu IconMobile Menu Close IconInstagramFacebookTwitterYoutubehttps://www.augustahealth.com/disease/lobular-carcinoma-in-situ-lcis/
These suggestions may help you cope with a diagnosis of LCIS: Learn enough about LCIS to make decisions about your care. […] If your biopsy reveals LCIS, you’ll likely have a follow-up appointment with your doctor. Questions you may want to ask your doctor about LCIS include: How much does LCIS increase my risk of breast cancer?