Materiały źródłowe

• #1 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529

  Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] LCIS usually doesn’t show up on mammograms. The condition is most often discovered as a result of a breast biopsy done for another reason, such as a suspicious breast lump or an abnormal mammogram. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer.

• #2 Lobular Carcinoma in Situ (LCIS)

  https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis

  Lobular carcinoma in situ (LCIS) is a rare breast condition. It causes abnormal cells in your lobules the glands in your breasts that produce breast milk. LCIS isnt breast cancer but it does increase the chance youll have breast cancer. […] Having LCIS doesnt mean you have a serious illness. But a diagnosis of LCIS does increase the chance that youll develop breast cancer later on. […] While it doesnt happen often, lobular carcinoma in situ may develop into ductal carcinoma in situ (DCIS) or lobular breast cancer. Studies show that 1 in 10 people with LCIS develop DCIS or lobular breast cancer. […] LCIS may not cause symptoms. For example, some people learn they have breast cancer after finding a lump in their breast that a test shows is a cancerous tumor. Instead, healthcare providers typically detect LCIS while viewing results from a breast biopsy done for another reason.

• #3 Lobular Carcinoma in Situ | LCIS | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html

  Lobular carcinoma in situ (LCIS) is a type of breast change that is sometimes seen when a breast biopsy is done. In LCIS, cells that look like cancer cells are growing in the lining of the milk-producing glands (lobules) of the breast, but they dont invade through the wall of the lobules. […] LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn’t become invasive breast cancer) if it isnt treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. […] Women with LCIS have about a 7 to 12 times higher risk of developing invasive cancer in either breast. For this reason, doctors typically recommend that women with LCIS have regular breast cancer screening tests and follow-up visits with a health care provider for the rest of their lives.

• #4 Lobular carcinoma in situ (LCIS): Symptoms, cancer, and more

  https://www.medicalnewstoday.com/articles/lcis

  Lobular carcinoma in situ (LCIS) is an abnormal growth of cells in the lining of the milk-producing glands of the breast, which are called lobules. […] While the cells look cancerous, LCIS does not invade the lobule walls or spread to other parts of the breast. […] If a person with LCIS does not receive treatment for the condition, it usually does not grow beyond the lobule. For this reason, doctors do not consider it cancer. […] However, after someone receives an LCIS diagnosis, their risk of developing breast cancer is 9 to 10 times higher than the general population. […] LCIS does not produce signs and symptoms such as lumps or changes in the appearance of the breast. It also may not show on a mammogram, partly because it often lacks the small calcium deposits that are sometimes characteristic of other types of breast cancer.

• #5 Lobular Carcinoma in Situ

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5841603/

  LCIS is both a risk factor and a non-obligate precursor of breast carcinoma. […] The relative risk of invasive carcinoma after a diagnosis of classic LCIS is approximately 9-10 times that of the general population. […] Classic LCIS is clinically and mammographically occult, although recent studies report an association with grouped amorphous or granular mammographic calcifications. […] The presence of variant LCIS close to the surgical margin of a resection specimen is reported, and re-excision should be considered. […] The cumulative risk of subsequent invasive breast carcinoma was 8% after 5 years, 15% after 10 years, 27% after 15 years, 35% after 20 years, and over 50% after 23 years. […] The relative risk of subsequent breast carcinoma in patients with LCIS is 9-10 times greater than that in the general population. […] The management of patients with variant LCIS and no invasive carcinoma upon excision is the subject of debate.

• #6

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4453073/

  Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). […] Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. […] Patients diagnosed with LCIS have an 8- to 10-fold increased lifetime risk of developing breast cancer, compared with women without this diagnosis. […] The likelihood of developing IBC increases by about 1 % every year after LCIS diagnosis – with a 13 % risk after 10 years and a 21 to 26 % risk after 20 years. […] In more contemporary series, however, several studies have shown a stronger propensity for development of ipsilateral IBC after diagnosis of LCIS.

• #7 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529

  Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] LCIS usually doesn’t show up on mammograms. The condition is most often discovered as a result of a breast biopsy done for another reason, such as a suspicious breast lump or an abnormal mammogram. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer.

• #8 Lobular carcinoma in situ (LCIS) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/lobular-carcinoma-in-situ-lcis

  LCIS doesn’t usually show up on breast x-rays (mammograms), and it normally doesn’t cause symptoms. […] It’s often diagnosed by chance during tests for other breast conditions, such as a biopsy. […] Although LCIS isn’t cancer, it means that you have a small increased risk of getting invasive breast cancer in either breast in the future. Even so, most women with LCIS won’t develop breast cancer. […] Your doctor might suggest that you have regular monitoring because there is an increased risk of breast cancer. […] If a cancer does develop, the monitoring should pick it up at a very early stage. Then you can have the treatment you need as early as possible.

• #9 LCIS: Symptoms, Causes, Diagnosis, Treatment & More

  https://www.healthline.com/health/lcis

  Most of the time there are no symptoms with LCIS. It does not cause discomfort or change in the appearance of the breast, and it seldom causes a noticeable lump. […] LCIS does not usually become invasive, but having it increases the risk of developing breast cancer in either breast in the future. […] The risk of developing invasive breast cancer is about 7 to 12 times higher for women who have had LCIS. Its more likely to happen 10 years or more down the road rather than within the first few years. Even with the increase in risk, most people with LCIS will never develop breast cancer.

• #10 Understanding lobular carcinoma in situ (LCIS) | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/pre-cancerous-and-genetic-conditions/lobular-carcinoma-in-situ

  Lobular carcinoma in situ (LCIS) is not a cancer. But it can increase the risk of developing cancer. […] LCIS usually has no symptoms, and it does not show on a mammogram. It is usually found by chance. […] If you have LCIS, you will not need any treatment. LCIS usually does not cause any problems. Most people with LCIS do not develop breast cancer, so they never need treatment. […] It is natural to feel worried if you know you have an increased risk of breast cancer. But LCIS is not cancer, and most people with LCIS do not develop breast cancer.

• #11 Invasive lobular carcinoma – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/symptoms-causes/syc-20373973

  At first, invasive lobular carcinoma may cause no signs and symptoms. As it grows larger, invasive lobular carcinoma may cause: […] Invasive lobular carcinoma is less likely to cause a firm or distinct breast lump than other types of breast cancer. […] Invasive lobular carcinoma cells tend to invade breast tissue by spreading out rather than forming a firm lump. The affected area may have a different feel from the surrounding breast tissue. The area may feel more like a thickening and fullness, but it’s unlikely to feel like a lump.

• #12 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Most of the time, breast cancer happens when cancer cells multiply to create a tumor. The tumor may make a lump in your breast that you can feel. ILC is different. Early on, ILC cells spread out in a single file to form strands or strings of cancer cells. […] As ILC grows slowly and may not form a lump, it may not cause noticeable changes in your breasts. When it does, symptoms can include: Breast pain or warmth, Breast skin that looks or feels thicker than usual or has dimples, tiny dents or puckers, Changes in breast size and shape, like an area of swelling or fullness, Inverted nipple that points into your breast instead of pointing out, Lump near your armpit, Nipple discharge, Skin discoloration that appears reddish or darker than usual. […] Invasive lobular carcinoma (ILC) is a type of breast cancer that starts in the milk-producing and transportation system of your breast. […] You may have ILC for years before its seen on a mammogram or causes symptoms. […] But ILC can spread to other areas of your body many years after your diagnosis and treatment.

• #13 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529

  Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] LCIS usually doesn’t show up on mammograms. The condition is most often discovered as a result of a breast biopsy done for another reason, such as a suspicious breast lump or an abnormal mammogram. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer.

• #14 Lobular Carcinoma in Situ (LCIS)

  https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis

  Lobular carcinoma in situ (LCIS) is a rare breast condition. It causes abnormal cells in your lobules the glands in your breasts that produce breast milk. LCIS isnt breast cancer but it does increase the chance youll have breast cancer. […] Having LCIS doesnt mean you have a serious illness. But a diagnosis of LCIS does increase the chance that youll develop breast cancer later on. […] While it doesnt happen often, lobular carcinoma in situ may develop into ductal carcinoma in situ (DCIS) or lobular breast cancer. Studies show that 1 in 10 people with LCIS develop DCIS or lobular breast cancer. […] LCIS may not cause symptoms. For example, some people learn they have breast cancer after finding a lump in their breast that a test shows is a cancerous tumor. Instead, healthcare providers typically detect LCIS while viewing results from a breast biopsy done for another reason.

• #15 Lobular carcinoma in situ (LCIS) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/lobular-carcinoma-in-situ-lcis

  LCIS doesn’t usually show up on breast x-rays (mammograms), and it normally doesn’t cause symptoms. […] It’s often diagnosed by chance during tests for other breast conditions, such as a biopsy. […] Although LCIS isn’t cancer, it means that you have a small increased risk of getting invasive breast cancer in either breast in the future. Even so, most women with LCIS won’t develop breast cancer. […] Your doctor might suggest that you have regular monitoring because there is an increased risk of breast cancer. […] If a cancer does develop, the monitoring should pick it up at a very early stage. Then you can have the treatment you need as early as possible.

• #16 Understanding Lobular Carcinoma In Situ (LCIS) | Breast Cancer Research Foundation

  https://www.bcrf.org/about-breast-cancer/lcis-lobular-carcinoma-in-situ/

  Lobular carcinoma in situ (LCIS): Its something most women have never heard of a benign, invisible breast condition with no symptoms but a diagnosis greatly increases your risk for breast cancer. […] LCIS does not usually cause any symptoms. Its typically diagnosed after a pathologist evaluates breast tissue from a biopsy deemed necessary because of an abnormal mammogram. […] Classic LCIS does not usually cause a lump to form or appear on a mammogram, but pleomorphic and florid LCIS can be found this way. […] The average risk of a woman developing breast cancer in her lifetime is 12 percent. That risk increases to 20 to 30 percent if a woman has been diagnosed with LCIS. The younger a woman is at diagnosis, the higher the risk.

• #17 Lobular Carcinoma in Situ (LCIS) | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/l/lobular-carcinoma-in-situ-lcis.html

  Lobular carcinoma in situ (LCIS), also known as lobular neoplasia, is a rare condition in which abnormal cells develop in the milk glands, known as lobules, in the breast. These abnormal cells are not considered to be breast cancer and don’t require any treatment beyond surgical removal. However, the presence of LCIS may increase the patient’s risk of developing breast cancer in either breast in the future. More aggressive breast cancer screening or preventative measures may be recommended. […] LCIS doesn’t cause any symptoms in most patients. In rare cases, the patient may notice a lump in their breast. […] Patients with LCIS have an increased risk of developing other types of breast cancer, requiring more careful observation of their breast health. This may include two clinical breast exams performed by a member of the medical team, more frequent self-exams, yearly mammograms or other imaging tools, such as magnetic resonance imaging (MRI), to observe any changes in the breast tissue. […] For some patients, preventative chemotherapy medicine, known as chemoprevention, may be used to lower their risk of developing breast cancer. The most common chemoprevention medications are tamoxifen and raloxifene, which can reduce the risk of breast cancer by half.

• #18 Lobular Carcinoma In Situ LCIS | Tampa General Hospital

  https://www.tgh.org/institutes-and-services/conditions/lobular-carcinoma-in-situ-lcis

  Lobular carcinoma in situ does not produce noticeable symptoms or mammogram features. The unusual pattern of cell growth can only be seen during the microscopic evaluation of the breast tissue. In most cases, LCIS is an incidental finding in a breast biopsy performed for an unrelated reason, such as to evaluate a suspicious breast lump. […] Compared to LCIS, DCIS is more common and more likely to progress into breast cancer. LCIS is considered to be a risk factor for breast cancer, while DCIS is considered to be a precursor to breast cancer. […] People who are diagnosed with lobular carcinoma in situ have a very good prognosis. With careful monitoring by an experienced physician and appropriate treatment when necessary, a patient with LCIS can remain healthy and cancer-free.

• #19 Lobular Carcinoma in Situ | LCIS | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html

  Lobular carcinoma in situ (LCIS) is a type of breast change that is sometimes seen when a breast biopsy is done. In LCIS, cells that look like cancer cells are growing in the lining of the milk-producing glands (lobules) of the breast, but they dont invade through the wall of the lobules. […] LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn’t become invasive breast cancer) if it isnt treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. […] Women with LCIS have about a 7 to 12 times higher risk of developing invasive cancer in either breast. For this reason, doctors typically recommend that women with LCIS have regular breast cancer screening tests and follow-up visits with a health care provider for the rest of their lives.

• #20 Lobular Carcinoma in Situ (LCIS) – Iowa Radiology

  https://www.iowaradiology.com/lobular-carcinoma-in-situ-lcis/

  Lobular carcinoma in situ (LCIS) describes the growth of abnormal cells in the breast lobules, the milk-producing glands at the ends of the milk ducts. In situ means that the abnormal cells are contained in their original place and have not invaded the surrounding tissue. […] Unlike many forms of breast cancer, LCIS typically causes no symptoms, and it often does not appear on screening mammograms. One reason for this is that microcalcifications, which form in other types of breast cancer cells and appear as white specks on a mammogram, may not be present with LCIS. As a result, many cases go undiagnosed, and often, this causes no harm. […] When LCIS is diagnosed, its usually a result of a biopsy investigating another breast condition in the vicinity of the abnormal cells. Under a microscope, LCIS can look much like DCIS. Both are described as stage 0, meaning that the abnormality has not spread beyond the original site. […] LCIS is most often diagnosed before menopause, between the ages of 40 and 50. More than half of patients are found to have abnormal cells in more than one lobule (called multifocal LCIS), and in about one third of LCIS patients, both breasts are affected.

• #21 Lobular Carcinoma In-Situ (LCIS)

  https://www.cbcn.ca/en/lobular-carcinoma-in-situ

  Lobular carcinoma in situ (LCIS) describes a condition in which there is abnormal cell growth in the lining on the lobules that dont invade the wall of the lobules. […] While LCIS is a benign condition and is not considered to be breast cancer, having LCIS puts a person at an approximately 7 to 12 times higher risk of later developing invasive breast cancer. […] There are no notable signs or symptoms of LCIS. […] Following a diagnosis of classic LCIS, the risk of going on to develop invasive carcinoma is about 9 to 10 times higher as compared to the general population. […] Classic LCIS is also generally positive for estrogen and/or progesterone receptors and negative for HER2. […] In pleomorphic LCIS, the cells lining the breast lobules and larger and more abnormal looking. […] 72% to 100% of cases of pleomorphic LCIS are positive for estrogen receptors (ER), 50% to 100% of cases are positive for progesterone receptors (PR), and in 1% to 41% of cases HER2 is overexpressed. […] Florid LCIS describes a condition where the cells that line the lobules have grown into a large group and become a mass, usually with sections of dead cells in the middle (referred to as central necrosis).

• #22 Lobular Carcinoma in Situ of the Breast | Oncohema Key

  https://oncohemakey.com/lobular-carcinoma-in-situ-of-the-breast/

  Lobular carcinoma in situ (LCIS) exists as two main subtypes, classic and pleomorphic. […] LCIS is usually discovered incidentally during biopsy for another indication. […] The lifetime risk of invasive cancer is 8 to 10 times that seen among women without LCIS. […] LCIS typically presents as an asymptomatic, occult lesion incidentally discovered during histologic workup for another clinical or radiographic indication. […] Women diagnosed with LCIS are typically quoted to have an 8- to 10-fold increased lifetime risk for developing breast cancer in both the ipsilateral and the contralateral breast. […] The absolute risk of breast cancer after LCIS is 20% to 25% after 20 years. […] Most instances of LCIS are incidentally discovered on breast biopsy conducted for another reason. […] LCIS is commonly widespread in the breast, with patterns that are multifocal, multicentric, and/or bilateral.

• #23

  https://www.kwongbreastclinic.com.sg/lobular-carcinoma-in-situ/

  Lobular carcinoma in situ (LCIS) is caused by abnormal cells forming within the milk glands (lobules) in the breast. […] LCIS is not a cancer but it does increase the risk of developing breast cancer. […] Lobular carcinoma in situ (LCIS) by itself does not usually cause symptoms but it is usually diagnosed after a biopsy is done for some other reason. […] In more than 50 percent of cases, Lobular Carcinoma in Situ may be multifocal, that is multiple lobules may have areas of abnormal cell growth. […] There is an increase of 20 percent cancer risk over 15 years at the point of diagnosis.

• #24 Lobular Carcinoma in Situ | LCIS | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html

  Lobular carcinoma in situ (LCIS) is a type of breast change that is sometimes seen when a breast biopsy is done. In LCIS, cells that look like cancer cells are growing in the lining of the milk-producing glands (lobules) of the breast, but they dont invade through the wall of the lobules. […] LCIS is not considered cancer, and it typically does not spread beyond the lobule (that is, it doesn’t become invasive breast cancer) if it isnt treated. But having LCIS does increase your risk of later developing an invasive breast cancer in either breast. […] Women with LCIS have about a 7 to 12 times higher risk of developing invasive cancer in either breast. For this reason, doctors typically recommend that women with LCIS have regular breast cancer screening tests and follow-up visits with a health care provider for the rest of their lives.

• #25 LCIS: Symptoms, Causes, Diagnosis, Treatment & More

  https://www.healthline.com/health/lcis

  Most of the time there are no symptoms with LCIS. It does not cause discomfort or change in the appearance of the breast, and it seldom causes a noticeable lump. […] LCIS does not usually become invasive, but having it increases the risk of developing breast cancer in either breast in the future. […] The risk of developing invasive breast cancer is about 7 to 12 times higher for women who have had LCIS. Its more likely to happen 10 years or more down the road rather than within the first few years. Even with the increase in risk, most people with LCIS will never develop breast cancer.

• #26 Lobular Carcinoma In-Situ (LCIS)

  https://cbcn.ca/en/lobular-carcinoma-in-situ

  Lobular carcinoma in situ (LCIS) describes a condition in which there is abnormal cell growth in the lining on the lobules that dont invade the wall of the lobules. […] While LCIS is a benign condition and is not considered to be breast cancer, having LCIS puts a person at an approximately 7 to 12 times higher risk of later developing invasive breast cancer. For women diagnosed with LCIS, the risk of developing breast cancer in 10 years is 10% and after 20 years of an LCIS diagnosis, the risk is 20%. […] There are no notable signs or symptoms of LCIS. Classis LCIS is generally not seen on mammograms, while pleomorphic and florid LCIS can sometimes be found in this way. However, all 3 types of LCIS are diagnosed by a breast biopsy, usually following a concerning mammogram result or while assessing another issue.

• #27 Lobular Breast Cancer And LCIS Characteristics | Food for Breast Cancer

  https://foodforbreastcancer.com/articles/lobular-breast-cancer-and-lcis-characteristics

  Women with lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (a possible precursor of both LCIS and invasive breast cancer) are at significantly higher than average risk for invasive breast cancer, but the risk is higher for developing both ductal and lobular breast cancer. […] One 2024 study reported that LCIS has both an immediate risk (19.3%) and a delayed risk (18.6%) of invasive breast cancer with 91% of such cancer occurring in the same breast as the LCIS and 9% in the opposite (contralateral) breast. […] A 2020 study found that 7.8% of women with atypical hyperplasia and 5.7% of women with LCIS developed invasive breast cancer during the first ten years after diagnosis. […] Another study reported that the seven-year cumulative invasive breast cancer incidence was 9.9% after an initial diagnosis of atypical hyperplasia or LCIS.

• #28 Recommendations for Women With Lobular Carcinoma In Situ (LCIS)

  https://www.cancernetwork.com/view/recommendations-women-lobular-carcinoma-situ-lcis

  Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) represent a spectrum of breast disease referred to as „lobular neoplasia” (LN). […] A diagnosis of LCIS is one of the greatest identifiable risk factors for the subsequent development of breast cancer. Compared to the general population, women with LCIS have an eight-fold to ten-fold increased risk of breast cancer. […] In the series with the longest follow-up, the probability of developing carcinoma in situ or invasive cancer was 13% in the first 10 years after diagnosis, 26% after 20 years, and 35% by 35 years, or roughly 1% per year. […] When counseling women about their risk, it is important to stress that the risk remains steady over their lifetime, and that the absolute risk of breast cancer for a given individual is therefore impacted by her age at LCIS diagnosis. Still, most women with LCIS will not develop breast cancer.

• #29 Lobular Carcinoma in Situ of the Breast | Oncohema Key

  https://oncohemakey.com/lobular-carcinoma-in-situ-of-the-breast/

  Lobular carcinoma in situ (LCIS) exists as two main subtypes, classic and pleomorphic. […] LCIS is usually discovered incidentally during biopsy for another indication. […] The lifetime risk of invasive cancer is 8 to 10 times that seen among women without LCIS. […] LCIS typically presents as an asymptomatic, occult lesion incidentally discovered during histologic workup for another clinical or radiographic indication. […] Women diagnosed with LCIS are typically quoted to have an 8- to 10-fold increased lifetime risk for developing breast cancer in both the ipsilateral and the contralateral breast. […] The absolute risk of breast cancer after LCIS is 20% to 25% after 20 years. […] Most instances of LCIS are incidentally discovered on breast biopsy conducted for another reason. […] LCIS is commonly widespread in the breast, with patterns that are multifocal, multicentric, and/or bilateral.

• #30 Lobular Breast Cancer And LCIS Characteristics | Food for Breast Cancer

  https://foodforbreastcancer.com/articles/lobular-breast-cancer-and-lcis-characteristics

  However, the cumulative risk of developing invasive breast cancer appears to continue to grow over time. […] A Canadian study reported that the 20-year cumulative risk of developing invasive breast cancer was 21.3% for LCIS patients. […] Another study reported that the annual incidence of breast cancer (including DCIS) was 2% among women with LCIS. […] Another study concluded that women under age 35 diagnosed with LCIS and other forms of atypical hyperplasia should be followed closely, receiving annual breast cancer screening starting at age 25 or age of diagnosis. […] This was based on the fact that 12% of such women developed breast cancer within a median of 90 months. […] Efforts to predict which LCIS patients will progress to invasive breast cancer have not been very successful.

• #31 Lobular Breast Cancer And LCIS Characteristics | Food for Breast Cancer

  https://foodforbreastcancer.com/articles/lobular-breast-cancer-and-lcis-characteristics

  However, one study found that LCIS with high Ki-67 (a marker of proliferation) expression is more likely to progress to invasive breast cancer than low Ki-67. […] Women with high breast density are also more likely to progress, as are women using HRT. […] In addition, LCIS that can be detected manually (palpable LCIS) is more likely to progress to invasive breast cancer. […] Note that palpable LCIS may feel like an area of thickening or firmness rather than a lump. […] Since the majority of women with LCIS do not go on to develop invasive breast cancer, some do not undergo surgery to remove the LCIS lesion. […] Rather, they are placed under increased surveillance and they may receive endocrine treatment. […] However, since a substantial minority of women diagnosed with LCIS based on core needle biopsy are found to have invasive breast cancer upon open surgical biopsy, some experts are of the opinion that surgical excision should follow needle biopsy to confirm that the diagnosis is limited to noninvasive breast cancer.

• #32

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4453073/

  These studies support a non-obligate precursor role of LCIS, in addition to being a risk factor for IBC. […] Currently, no diagnostic tools exist which can reliably predict if a woman will subsequently develop IBC after diagnosis of LCIS. […] The key to determining whether a LCIS lesion will progress will lie in the molecular characteristics of the lesion, including genetic aberrations in important signaling pathways, and alterations in EMT pathways.

• #33 Molecular drivers of lobular carcinoma in situ | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0580-5

  Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). […] Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. […] The likelihood of developing IBC increases by about 1 % every year after LCIS diagnosis – with a 13 % risk after 10 years and a 21 to 26 % risk after 20 years. […] In more contemporary series, however, several studies have shown a stronger propensity for development of ipsilateral IBC after diagnosis of LCIS. […] These studies support a non-obligate precursor role of LCIS. […] Currently, no diagnostic tools exist which can reliably predict if a woman will subsequently develop IBC after diagnosis of LCIS. […] The key to determining whether a LCIS lesion will progress will lie in the molecular characteristics of the lesion, including genetic aberrations in important signaling pathways, and alterations in EMT pathways.

• #34 Lobular Carcinoma in Situ (LCIS)

  https://my.clevelandclinic.org/health/diseases/21791-lobular-carcinoma-in-situ-lcis

  That depends on your situation, including the type of LCIS that you have. If you wonder what to expect, ask your healthcare provider to explain whats going on in your breast and your treatment options. Understanding your options will help you feel more confident about your plan for living with LCIS. […] LCIS may not become invasive breast cancer, but it can happen. When it does, it can take 10 to 15 years to happen. Even so, treatment often cures invasive breast cancer that started as lobular carcinoma in situ.

• #35

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/lobular-carcinoma-in-situ

  Lobular carcinoma in situ (LCIS) is a non-cancerous condition where abnormal cells grow in the milk glands of your breast. While LCIS is not breast cancer, your risk of getting cancer increases if you’re diagnosed with it. […] LCIS is not considered cancer, but it does indicate a greater risk for developing breast cancer in the future. Yet, it doesn’t always lead to cancer itself. […] There is no way to tell how long it will take for LCIS to become invasive breast cancer, if it does at all. Most cases of LCIS never progress into invasive breast cancer. […] Regular monitoring and follow-up care are crucial if you have LCIS so any signs of progression or development of invasive cancer can be detected early. […] LCIS doesn’t cause symptoms since it’s restricted to the breasts lobules. Your doctor may discover LCIS through an abnormal mammogram or biopsy for a lump in your breast.

• #36

  https://step2.medbullets.com/oncology/120424/lobular-carcinoma-in-situ-lcis

  A 62-year-old women presents to her primary care physician with a mass in the right breast, which she believes was the result of trauma. On exam there is a firm, fixed 1 cm mass in the right breast in the upper outer quandrant. There is no axillary lyphadenopathy. […] Symptoms include asymptomatic and breast lump. […] Physical exam may detect a breast lump or it may not be palpable. […] If untreated LCIS will become invasive in 20-30% of patients over a prolonged period of time (10-15 years). […] Majority are estrogen and progesterone positive. […] Development of invasive carcinoma. […] Very good prognosis; majority of women with LCIS will not develop invasive breast cancer.

• #37 Lobular Carcinoma In Situ (LCIS) Breast Cancer: Symptoms, Causes and Treatment

  https://gangabreastcare.com/lobular-carcinoma-in-situ.php

  Lobular Carcinoma in Situ (LCIS) is a carcinoma which arises and limited to the cells lining the milk-producing glands of the breast. […] LCIS is mostly asymptomatic and is diagnosed most commonly in biopsies taken from the breast. […] Patients who have LCIS are more prone to develop an invasive carcinoma of the breast(30-40%) when compared to those who do not have LCIS (12.5%). Those who develop invasive carcinoma of the breast develop it over a long period from the onset of LCIS (around 10 to 15 years). […] As the LCIS are seen in multiple areas of the breast and as they develop into cancers after a long period, no specific treatment is needed other than regular followup.

• #38 Recommendations for Women With Lobular Carcinoma In Situ (LCIS)

  https://www.cancernetwork.com/view/recommendations-women-lobular-carcinoma-situ-lcis

  Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) represent a spectrum of breast disease referred to as „lobular neoplasia” (LN). […] A diagnosis of LCIS is one of the greatest identifiable risk factors for the subsequent development of breast cancer. Compared to the general population, women with LCIS have an eight-fold to ten-fold increased risk of breast cancer. […] In the series with the longest follow-up, the probability of developing carcinoma in situ or invasive cancer was 13% in the first 10 years after diagnosis, 26% after 20 years, and 35% by 35 years, or roughly 1% per year. […] When counseling women about their risk, it is important to stress that the risk remains steady over their lifetime, and that the absolute risk of breast cancer for a given individual is therefore impacted by her age at LCIS diagnosis. Still, most women with LCIS will not develop breast cancer.

• #39 Lobular Carcinoma in Situ

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5841603/

  LCIS is both a risk factor and a non-obligate precursor of breast carcinoma. […] The relative risk of invasive carcinoma after a diagnosis of classic LCIS is approximately 9-10 times that of the general population. […] Classic LCIS is clinically and mammographically occult, although recent studies report an association with grouped amorphous or granular mammographic calcifications. […] The presence of variant LCIS close to the surgical margin of a resection specimen is reported, and re-excision should be considered. […] The cumulative risk of subsequent invasive breast carcinoma was 8% after 5 years, 15% after 10 years, 27% after 15 years, 35% after 20 years, and over 50% after 23 years. […] The relative risk of subsequent breast carcinoma in patients with LCIS is 9-10 times greater than that in the general population. […] The management of patients with variant LCIS and no invasive carcinoma upon excision is the subject of debate.

• #40 Lobular Carcinoma in Situ of the Breast | Oncohema Key

  https://oncohemakey.com/lobular-carcinoma-in-situ-of-the-breast/

  The risks of cancer in the ipsilateral and the contralateral breast are approximately equal, as shown in multiple longitudinal studies of patients diagnosed with LCIS by surgical biopsy. […] It is possible that some subgroups of LCIS may exhibit a more aggressive unilateral biology and preinvasive behavior.

• #41 Lobular Breast Cancer And LCIS Characteristics | Food for Breast Cancer

  https://foodforbreastcancer.com/articles/lobular-breast-cancer-and-lcis-characteristics

  It is also important for women who do progress to invasive breast cancer to have all of their LCIS surgically removed. […] The picture is more clear for pleomorphic lobular carcinoma in situ (PLCIS), a higher-risk type of LCIS which is more likely to progress. […] When patients are diagnosed with PLCIS using a needle biopsy, the lesion should be surgically removed. […] In addition, re-excision should be performed if any PLCIS or LCIS is found at or near the surgical margins.

• #42 Lobular Breast Cancer And LCIS Characteristics | Food for Breast Cancer

  https://foodforbreastcancer.com/articles/lobular-breast-cancer-and-lcis-characteristics

  However, the cumulative risk of developing invasive breast cancer appears to continue to grow over time. […] A Canadian study reported that the 20-year cumulative risk of developing invasive breast cancer was 21.3% for LCIS patients. […] Another study reported that the annual incidence of breast cancer (including DCIS) was 2% among women with LCIS. […] Another study concluded that women under age 35 diagnosed with LCIS and other forms of atypical hyperplasia should be followed closely, receiving annual breast cancer screening starting at age 25 or age of diagnosis. […] This was based on the fact that 12% of such women developed breast cancer within a median of 90 months. […] Efforts to predict which LCIS patients will progress to invasive breast cancer have not been very successful.

• #43 Lobular carcinoma in situ (LCIS) – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lobular-carcinoma-in-situ/symptoms-causes/syc-20374529

  Lobular carcinoma in situ (LCIS) is an uncommon condition in which abnormal cells form in the milk glands (lobules) in the breast. Lobular carcinoma in situ (LCIS) isn’t cancer. But being diagnosed with LCIS indicates that you have an increased risk of developing breast cancer. […] LCIS usually doesn’t show up on mammograms. The condition is most often discovered as a result of a breast biopsy done for another reason, such as a suspicious breast lump or an abnormal mammogram. […] Women with LCIS have an increased risk of developing invasive breast cancer in either breast. If you’re diagnosed with LCIS, your doctor may recommend increased breast cancer screening and may ask you to consider medical treatments to reduce your risk of developing invasive breast cancer. […] LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer.

• #44 Lobular Carcinoma in Situ (LCIS) | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/l/lobular-carcinoma-in-situ-lcis.html

  Lobular carcinoma in situ (LCIS), also known as lobular neoplasia, is a rare condition in which abnormal cells develop in the milk glands, known as lobules, in the breast. These abnormal cells are not considered to be breast cancer and don’t require any treatment beyond surgical removal. However, the presence of LCIS may increase the patient’s risk of developing breast cancer in either breast in the future. More aggressive breast cancer screening or preventative measures may be recommended. […] LCIS doesn’t cause any symptoms in most patients. In rare cases, the patient may notice a lump in their breast. […] Patients with LCIS have an increased risk of developing other types of breast cancer, requiring more careful observation of their breast health. This may include two clinical breast exams performed by a member of the medical team, more frequent self-exams, yearly mammograms or other imaging tools, such as magnetic resonance imaging (MRI), to observe any changes in the breast tissue. […] For some patients, preventative chemotherapy medicine, known as chemoprevention, may be used to lower their risk of developing breast cancer. The most common chemoprevention medications are tamoxifen and raloxifene, which can reduce the risk of breast cancer by half.

• #45 Lobular Carcinoma in Situ (LCIS) | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/l/lobular-carcinoma-in-situ-lcis.html

  Lobular carcinoma in situ (LCIS), also known as lobular neoplasia, is a rare condition in which abnormal cells develop in the milk glands, known as lobules, in the breast. These abnormal cells are not considered to be breast cancer and don’t require any treatment beyond surgical removal. However, the presence of LCIS may increase the patient’s risk of developing breast cancer in either breast in the future. More aggressive breast cancer screening or preventative measures may be recommended. […] LCIS doesn’t cause any symptoms in most patients. In rare cases, the patient may notice a lump in their breast. […] Patients with LCIS have an increased risk of developing other types of breast cancer, requiring more careful observation of their breast health. This may include two clinical breast exams performed by a member of the medical team, more frequent self-exams, yearly mammograms or other imaging tools, such as magnetic resonance imaging (MRI), to observe any changes in the breast tissue. […] For some patients, preventative chemotherapy medicine, known as chemoprevention, may be used to lower their risk of developing breast cancer. The most common chemoprevention medications are tamoxifen and raloxifene, which can reduce the risk of breast cancer by half.

• #46 Lobular Carcinoma in Situ | LCIS | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/non-cancerous-breast-conditions/lobular-carcinoma-in-situ.html

  Having LCIS does increase your risk of developing invasive breast cancer later on. But since LCIS is not a true cancer or pre-cancer, often no treatment is needed after the biopsy. […] Close follow-up is important because women with LCIS have the same increased risk of developing cancer in both breasts.

• #47 Lobular carcinoma in situ (LCIS) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/lobular-carcinoma-in-situ-lcis

  LCIS doesn’t usually show up on breast x-rays (mammograms), and it normally doesn’t cause symptoms. […] It’s often diagnosed by chance during tests for other breast conditions, such as a biopsy. […] Although LCIS isn’t cancer, it means that you have a small increased risk of getting invasive breast cancer in either breast in the future. Even so, most women with LCIS won’t develop breast cancer. […] Your doctor might suggest that you have regular monitoring because there is an increased risk of breast cancer. […] If a cancer does develop, the monitoring should pick it up at a very early stage. Then you can have the treatment you need as early as possible.

• #48 Lobular Carcinoma in Situ (LCIS) | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/l/lobular-carcinoma-in-situ-lcis.html

  Lobular carcinoma in situ (LCIS), also known as lobular neoplasia, is a rare condition in which abnormal cells develop in the milk glands, known as lobules, in the breast. These abnormal cells are not considered to be breast cancer and don’t require any treatment beyond surgical removal. However, the presence of LCIS may increase the patient’s risk of developing breast cancer in either breast in the future. More aggressive breast cancer screening or preventative measures may be recommended. […] LCIS doesn’t cause any symptoms in most patients. In rare cases, the patient may notice a lump in their breast. […] Patients with LCIS have an increased risk of developing other types of breast cancer, requiring more careful observation of their breast health. This may include two clinical breast exams performed by a member of the medical team, more frequent self-exams, yearly mammograms or other imaging tools, such as magnetic resonance imaging (MRI), to observe any changes in the breast tissue. […] For some patients, preventative chemotherapy medicine, known as chemoprevention, may be used to lower their risk of developing breast cancer. The most common chemoprevention medications are tamoxifen and raloxifene, which can reduce the risk of breast cancer by half.

• #49 Lobular carcinoma in situ (LCIS): Symptoms, cancer, and more

  https://www.medicalnewstoday.com/articles/lcis

  Although LCIS is not invasive breast cancer, it increases a person’s risk of developing the disease. It has no symptoms, so doctors usually diagnose it when they perform a biopsy for another breast-related condition. […] Treatment may consist of surgically removing the abnormal cells along with a small amount of healthy tissue surrounding them. To reduce the risk of breast cancer, doctors may also recommend a person take estrogen-blocking or estrogen-reducing medications because the hormone may impact breast cancer cell growth. […] The authors of the study also mention a 2017 analysis that found that females with LCIS who develop breast cancer usually get an early-stage diagnosis. The outlook for LCIS is encouraging, considering the 10- and 20-year breast cancer-specific survival rate was 98.9% and 96.3%, respectively.

• #50 Lobular Carcinoma In Situ (LCIS) – Breast Cancer | UCLA Health Jonsson Comprehensive Cancer Center

  https://www.uclahealth.org/cancer/cancer-services/breast-cancer/breast-health-services/breast-cancer/lobular-carcinoma-situ-lcis

  LCIS is typically found incidentally on a biopsy that is done for calcifications or another abnormality found on breast imaging. It rarely causes symptoms. […] Although LCIS does not require treatment, the diagnosis increases a patients risk, so consideration of risk-reducing interventions and enhanced breast cancer screening should be discussed. Treatment with hormone blocking therapy has been shown to decrease the risk of breast cancer development in patients with LCIS by 56%.

• #51 Lobular Carcinoma in Situ | Nebraska Hematology Oncology – Cancer Care Treatment Blood Disorders Clinical Trials Lincoln Nebraska (NE)

  https://www.yourcancercare.com/types-of-cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ

  Observation is a generally accepted form of management for patients with LCIS. Many patients have received no further treatment following initial surgical removal of LCIS for diagnosis. In one study, researchers from the National Surgical Adjuvant Breast and Bowel Project (NSABP) evaluated 182 patients with LCIS. With a 5-year follow-up, the risk of developing invasive breast cancer after excisional biopsy alone was 3.3%, with 2.2% involving the same breast as the biopsy and 1.1% involving the opposite breast. […] In patients with LCIS, the incidence of invasive breast cancer was reduced 56% by the administration of Nolvadex.

• #52 Lobular carcinoma in situ (LCIS) | Health Library | Memorial Health System

  https://www.mhsystem.org/health-library/con-20374514/

  Surgery may be recommended in certain situations. For instance, surgery is often recommended for a specific type of LCIS called pleomorphic lobular carcinoma in situ (PLCIS). This type of LCIS is thought to carry a greater risk of breast cancer than is the more common classical type. […] Another option for treating LCIS is preventive (prophylactic) mastectomy. This surgery removes both breasts not just the breast affected with LCIS to reduce your risk of developing invasive breast cancer.

• #53 Lobular carcinoma in situ (LCIS) | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/lobular-carcinoma-in-situ-lcis?content_id=CON-20374514

  Lobular carcinoma in situ (LCIS) may be present in one or both breasts, but it usually isn’t visible on a mammogram. The condition is most often diagnosed as an incidental finding when you have a biopsy done to evaluate some other area of concern in your breast. […] Surgery may be recommended in certain situations. For instance, surgery is often recommended for a specific type of LCIS called pleomorphic lobular carcinoma in situ (PLCIS). This type of LCIS is thought to carry a greater risk of breast cancer than is the more common classical type. […] Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer.

• #54 Lobular Carcinoma in Situ – Cancer Specialists of Tidewater

  https://tidewatercancer.com/types-of-cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ/

  The treatment of lobular carcinoma in situ (LCIS) is somewhat controversial. LCIS is thought to be an indicator for an increased risk of developing invasive breast cancer, but may not be a direct precursor to invasive breast cancer. This abnormality is generally widely distributed throughout the breast and frequently occurs in both breasts simultaneously. […] From long-term retrospective studies, it is estimated that approximately 25% of patients with LCIS will develop invasive breast cancer within 25 years of diagnosis. Thus, this diagnosis is being used to identify patients at high risk of subsequently developing invasive breast cancer. Current approaches for management of LCIS include surgical removal of the LCIS or treatment with anti-estrogens to reduce the risk of developing invasive cancer.

• #55 Lobular Carcinoma in Situ | Nebraska Hematology Oncology – Cancer Care Treatment Blood Disorders Clinical Trials Lincoln Nebraska (NE)

  https://www.yourcancercare.com/types-of-cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ

  The treatment of lobular carcinoma in situ (LCIS) is somewhat controversial. LCIS is thought to be an indicator for an increased risk of developing invasive breast cancer, but may not be a direct precursor to invasive breast cancer. This abnormality is generally widely distributed throughout the breast and frequently occurs in both breasts simultaneously. […] From long-term retrospective studies, it is estimated that approximately 25% of patients with LCIS will develop invasive breast cancer within 25 years of diagnosis. Thus, this diagnosis is being used to identify patients at high risk of subsequently developing invasive breast cancer. Current approaches for management of LCIS include surgical removal of the LCIS or treatment with anti-estrogens to reduce the risk of developing invasive cancer.

• #56 Lobular Carcinoma In Situ LCIS | Tampa General Hospital

  https://www.tgh.org/institutes-and-services/conditions/lobular-carcinoma-in-situ-lcis

  Lobular carcinoma in situ does not produce noticeable symptoms or mammogram features. The unusual pattern of cell growth can only be seen during the microscopic evaluation of the breast tissue. In most cases, LCIS is an incidental finding in a breast biopsy performed for an unrelated reason, such as to evaluate a suspicious breast lump. […] Compared to LCIS, DCIS is more common and more likely to progress into breast cancer. LCIS is considered to be a risk factor for breast cancer, while DCIS is considered to be a precursor to breast cancer. […] People who are diagnosed with lobular carcinoma in situ have a very good prognosis. With careful monitoring by an experienced physician and appropriate treatment when necessary, a patient with LCIS can remain healthy and cancer-free.

• #57 Lobular carcinoma in situ – Wikipedia

  https://en.wikipedia.org/wiki/Lobular_carcinoma_in_situ

  Lobular carcinoma in situ (LCIS) is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns. […] Many do not consider LCIS to be a true case of cancer, but it can indicate an increased risk of future cancer. […] Lobular neoplasia is considered pre-cancerous, and LCIS is an indicator (marker) for increased risk of developing invasive breast cancer in women. This risk extends more than 20 years. […] The relative risk of developing invasive carcinoma after LCIS diagnosis is 8-10 times greater than in the general population. […] The overall 5-year survival rate of lobular carcinoma in situ has been estimated to be 97%.

• #58 Lobular carcinoma in situ (LCIS): Symptoms, cancer, and more

  https://www.medicalnewstoday.com/articles/lcis

  Although LCIS is not invasive breast cancer, it increases a person’s risk of developing the disease. It has no symptoms, so doctors usually diagnose it when they perform a biopsy for another breast-related condition. […] Treatment may consist of surgically removing the abnormal cells along with a small amount of healthy tissue surrounding them. To reduce the risk of breast cancer, doctors may also recommend a person take estrogen-blocking or estrogen-reducing medications because the hormone may impact breast cancer cell growth. […] The authors of the study also mention a 2017 analysis that found that females with LCIS who develop breast cancer usually get an early-stage diagnosis. The outlook for LCIS is encouraging, considering the 10- and 20-year breast cancer-specific survival rate was 98.9% and 96.3%, respectively.

• #59 Lobular carcinoma in situ – Wikipedia

  https://en.wikipedia.org/wiki/Lobular_carcinoma_in_situ

  Lobular carcinoma in situ (LCIS) is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns. […] Many do not consider LCIS to be a true case of cancer, but it can indicate an increased risk of future cancer. […] Lobular neoplasia is considered pre-cancerous, and LCIS is an indicator (marker) for increased risk of developing invasive breast cancer in women. This risk extends more than 20 years. […] The relative risk of developing invasive carcinoma after LCIS diagnosis is 8-10 times greater than in the general population. […] The overall 5-year survival rate of lobular carcinoma in situ has been estimated to be 97%.

• #60 Lobular carcinoma in situ (LCIS): Symptoms, cancer, and more

  https://www.medicalnewstoday.com/articles/lcis

  Although LCIS is not invasive breast cancer, it increases a person’s risk of developing the disease. It has no symptoms, so doctors usually diagnose it when they perform a biopsy for another breast-related condition. […] Treatment may consist of surgically removing the abnormal cells along with a small amount of healthy tissue surrounding them. To reduce the risk of breast cancer, doctors may also recommend a person take estrogen-blocking or estrogen-reducing medications because the hormone may impact breast cancer cell growth. […] The authors of the study also mention a 2017 analysis that found that females with LCIS who develop breast cancer usually get an early-stage diagnosis. The outlook for LCIS is encouraging, considering the 10- and 20-year breast cancer-specific survival rate was 98.9% and 96.3%, respectively.

• #61 Lobular Carcinoma in Situ: Symptoms, Causes, Treatment | Qwark

  https://qwarkhealth.com/conditions/lobular-carcinoma-in-situ

  Common symptoms of Lobular Carcinoma in Situ (LCIS) are not noticeable as there are no physical symptoms or lumps that can be felt in the breast. […] LCIS usually does not come with any noticeable physical symptoms, making it challenging to diagnose without medical imaging tests. […] The typical prognosis for Lobular Carcinoma in Situ (LCIS) is excellent. LCIS is not a cancer but a condition that increases the risk of developing invasive breast cancer later in life. […] LCIS itself does not usually develop into invasive cancer. However, it is a risk factor for developing invasive cancer later in life, particularly in the same breast or opposite breast. […] The common factors that affect the prognosis of LCIS include the patient`s age, family history of breast cancer, the type of LCIS, the presence of other risk factors such as obesity or a history of benign breast disease, and the use of hormone replacement therapy. […] The current treatment options for LCIS include close monitoring, preventive measures such as hormone therapy or prophylactic mastectomy, and lifestyle changes such as maintaining a healthy weight and exercising regularly.

• #62 Lobular Carcinoma in Situ (LCIS)

  https://www.cancercenter.com/cancer-types/breast-cancer/risk-factors/lobular-carcinoma-in-situ

  Lobular carcinoma in situ, also known as LCIS, is a medical condition that causes abnormal cells to grow in the breast glands that are responsible for producing milk, known as the lobules. The abnormal cells remain in the walls of the lobular cells and dont spread to the breast tissue or other parts of the body. […] LCIS isnt cancer but having the condition may increase the risk of developing invasive breast cancer in the future. According to the American Cancer Society, the risk of invasive breast cancer is seven to 12 times higher if someone was previously diagnosed with LCIS, which is why regular screenings are important. […] Unlike some other health conditions, LCIS generally doesnt cause symptoms, so patients may not notice bodily changes or signs. It also doesnt usually show up on mammogram tests a diagnostic tool that uses an X-ray to take pictures of the breast to screen for breast cancer. […] Instead, LCIS is most often diagnosed when breast biopsies are performed for other reasons. In a biopsy, another type of diagnostic test, the doctor takes a cell sample from the breast and examines it under a microscope, looking for signs of abnormal cells.

• #63 Lobular carcinoma in situ (LCIS) | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/lobular-carcinoma-situ-lcis

  LCIS doesn’t cause signs or symptoms. Rather, your doctor might discover incidentally that you have LCIS for instance, after a biopsy to assess a breast lump or an abnormal area found on a mammogram. […] If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer. […] The risk of breast cancer in women diagnosed with LCIS is thought to be approximately 20 percent. Put another way, for every 100 women diagnosed with LCIS, 20 will be diagnosed with breast cancer and 80 won’t be diagnosed with breast cancer. The risk of developing breast cancer for women in general is thought to be 12 percent. Put another way, for every 100 women in the general population, 12 will be diagnosed with breast cancer.

• #64 Annual screening of Lobular Breast Cancer – DCIS/LCIS – Breast Cancer Now forum

  https://forum.breastcancernow.org/t/annual-screening-of-lobular-breast-cancer/118029

  Hi I was diagnosed with lobular breast cancer 3 years ago on a routine mammogram. […] I do wonder if the evidence that LBC tends to be diagnosed in older women isnt because it actually occurs more in older women its thats we get diagnosed later. There is some evidence that its slower growing. […] I was diagnosed with IDC/DCIS and LCIS two years ago. […] Im concerned that the LCIS makes me more prone to a lobular invasive cancer on my remaining side. […] It certainly wasnt spotted on my earlier mammograms. […] I am also worried about the effectiveness of an annual mammogram. […] I had a normal mammogram in May 2021 but 6 weeks later noticed a lump. […] The initial statement for ongoing follow ups was annual mammograms for 5 years to which I just asked what was the point when absolutely nothing had been seen?

• #65 Annual screening of Lobular Breast Cancer – DCIS/LCIS – Breast Cancer Now forum

  https://forum.breastcancernow.org/t/annual-screening-of-lobular-breast-cancer/118029

  Its essential, in my opinion, to have MRI for lobular but even that underestimated the tumour sizes so would not necessarily pick up very small ones. […] I feel so worried now as nothing was found on mammogram scan or biopsy. […] I am now terrified I have got the sneaky cancer in my remaining breast but noone seems concerned. […] I only have annual mammograms post mastectomy and it worries me that lobular cancer doesnt show up well or at all on mammograms. […] My cancer was a low grade invasive ductal but when they find LCIS as an incidental finding at biopsy, as they did with me, it can suggest you are at much greater risk for further invasive lobular cancers. […] I think I will take up that MRI. […] My experience is similar to most of you ladies here. My two tumours did not show on the mammogram, even though one of them could be clearly felt. […] I think 10/15% of BC are lobular? Coincidence?

• #66 Lobular carcinoma in situ (LCIS) | EBSCO Research Starters

  https://www.ebsco.com/research-starters/health-and-medicine/lobular-carcinoma-situ-lcis

  Lobular carcinoma in situ (LCIS) is a noninvasive breast condition that arises within the lobules of the breast and is characterized by abnormal cell growth. […] The condition can often be asymptomatic, complicating early detection. […] LCIS is often missed due to the lack of overt signs and symptoms like those associated with other breast lesions, such as the incidental discovery of a breast mass on self-examination, changes in the skin or nipples, and the presence of pain or nipple discharge. […] Despite this, the development of invasive cancer from LCIS is slow and may take as long as fifteen to twenty years. […] Prognosis is generally excellent with complete excision. However, progression to multiple or bilateral LCIS is high, approaching 90 percent and 70 percent, respectively. Additionally, an LCIS diagnosis indicates an increased risk of breast cancer later in life. Some evidence suggests that 8 percent of women will develop ductal carcinoma in situ (DCIS) breast cancer within five years of an LCIS diagnosis and 20 percent within fifteen years of diagnosis.

• #67 Case: Lobular Carcinoma in Situ (LCIS) – Radiology | UCLA Health

  https://www.uclahealth.org/departments/radiology/education/breast-imaging-teaching-resources/cases/case-lcis

  Lobular carcinoma in situ (LCIS) is a noninvasive lesion of the breast considered to be a nonobligate precursor of invasive lobular carcinoma. […] LCIS has been described as clinically occult. It is found to be multicentric in most cases and is often bilateral. […] LCIS is seen most often in premenopausal women (mean age of 49 years). In postmenopausal women, long-term HRT use is associated with the risk of developing LCIS. […] The imaging features of LCIS are nonspecific. On mammography, LCIS is most frequently occult. […] When present, the most common mammographic finding is microcalcifications which may be of variable morphology and distribution, most often grouped and amorphous. […] On sonography, LCIS may appear as oval, hypoechoic masses with circumscribed or microlobulated margins.

• #68 Case: Lobular Carcinoma in Situ (LCIS) – Radiology | UCLA Health

  https://www.uclahealth.org/departments/radiology/education/breast-imaging-teaching-resources/cases/case-lcis

  When LCIS is seen on MRI, the most common finding is non-mass enhancement. […] The management of LCIS is currently evolving and varies across institutions, with some recommending surgical excision and others surveillance. […] According to 2023 NCCN guidelines, a core biopsy showing classic LCIS can be managed without surgical excision, which should be considered on a case-by-case basis. […] Chemoprevention with selective estrogen receptor modulars or aromatase inhibitors can reduce the risk of breast cancer in patients with LCIS.

• #69 Lobular carcinoma in situ (LCIS) | Health Library | Memorial Health System

  https://www.mhsystem.org/health-library/con-20374514/

  If LCIS is detected in a breast biopsy, it doesnt mean that you have cancer. But having LCIS increases your risk of breast cancer and makes it more likely that you may develop invasive breast cancer. […] The risk of breast cancer in women diagnosed with LCIS is thought to be approximately 20 percent. […] Lobular carcinoma in situ (LCIS) may be present in one or both breasts, but it usually isnt visible on a mammogram. The condition is most often diagnosed as an incidental finding when you have a biopsy done to evaluate some other area of concern in your breast. […] If youve been diagnosed with LCIS, your doctor may recommend more frequent exams to closely monitor your breasts for signs of cancer. […] Preventive therapy (chemoprevention) involves taking a medication to reduce your risk of breast cancer.

• #70 Lobular Carcinoma in Situ – Virginia Cancer Institute

  https://www.vacancer.com/cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ/

  Observation is a generally accepted form of management for patients with LCIS. Many patients have received no further treatment following initial surgical removal of LCIS for diagnosis. In one study, researchers from the National Surgical Adjuvant Breast and Bowel Project (NSABP) evaluated 182 patients with LCIS. With a 5-year follow-up, the risk of developing invasive breast cancer after excisional biopsy alone was 3.3%, with 2.2% involving the same breast as the biopsy and 1.1% involving the opposite breast. […] Because of the observation that women with breast cancer treated with Nolvadex had a lower risk of developing a new breast cancer in their unaffected breast, many doctors felt that Nolvadex may actually be able to prevent breast cancer from occurring. […] In patients with LCIS, the incidence of invasive breast cancer was reduced 56% by the administration of Nolvadex.

• #71 Recommendations for Women With Lobular Carcinoma In Situ (LCIS)

  https://www.cancernetwork.com/view/recommendations-women-lobular-carcinoma-situ-lcis

  Recent studies have also highlighted the high proportion of infiltrating lobular carcinomas that occur following a diagnosis of LCIS. […] The presence of shared molecular alterations in LCIS and co-existing invasive lobular carcinoma have led some investigators to suggest that LN is a nonobligate precursor of low-grade invasive breast cancer. […] The decision to undergo BPM is highly individual and should not be undertaken without ample time to consider all of the available options for risk management.

• #72 Lobular Carcinoma in Situ – Virginia Cancer Institute

  https://www.vacancer.com/cancer/breast-cancer/carcinoma-in-situ/lobular-carcinoma-in-situ/

  Based on the results of this clinical study, the Food and Drug Administration concluded that Nolvadex should be approved for reducing the risk of breast cancer in women at high risk of developing breast cancer. Additional follow-up and the results of other clinical studies will further clarify the role of Nolvadex and other hormonal therapies in the prevention of breast cancer. All patients with LCIS may want to consider treatment intervention with Nolvadex or other anti-estrogens.

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