Rak gruczołów łojowych

Rak gruczołów łojowych
Leczenie

Rak sebacytowy to agresywny nowotwór skóry wywodzący się z gruczołów łojowych, najczęściej lokalizujący się na powiekach oraz skórze głowy i szyi. Podstawową metodą leczenia jest chirurgia mikrograficzna Mohsa (MMS), która umożliwia precyzyjne usunięcie guza z oceną marginesów w czasie rzeczywistym, co znacząco redukuje ryzyko nawrotów miejscowych (około 11%) i przerzutów regionalnych (6-8%) w porównaniu do szerokiego wycięcia miejscowego (WLE) z marginesem 5-6 mm, które wiąże się z 5-letnią śmiertelnością na poziomie 18% oraz nawrotami w 30-37% przypadków. W przypadku rozległego zajęcia powiek lub naciekania tkanek oczodołu konieczna może być egzenteracja oczodołu. Po resekcji często stosuje się chirurgię rekonstrukcyjną w celu przywrócenia funkcji i estetyki. Radioterapia pełni rolę uzupełniającą, szczególnie w guzach T3 po egzenteracji, przy dodatnich marginesach lub przerzutach do węzłów chłonnych, a brachyterapia stanowi skuteczną opcję w leczeniu oczodołowym. Krioterapia i miejscowe stosowanie mitomycyny C mogą być rozważane w wybranych przypadkach, zwłaszcza przy zajęciu spojówki.

Metody chirurgiczne leczenia raka sebacytowego

Rak sebacytowy (sebaceous carcinoma) to rzadki, ale agresywny nowotwór skóry wywodzący się z gruczołów łojowych, który najczęściej występuje w obrębie powiek oraz skóry głowy i szyi. Ze względu na jego skłonność do szybkiego wzrostu, nawrotów i przerzutów, leczenie chirurgiczne stanowi podstawową metodę terapeutyczną¹².

Chirurgia mikrograficzna Mohsa

Chirurgia mikrograficzna Mohsa (Mohs micrographic surgery – MMS) jest obecnie preferowaną metodą leczenia raka sebacytowego. Technika ta polega na stopniowym usuwaniu cienkich warstw guza i otaczających tkanek, które są natychmiast badane pod mikroskopem w celu oceny marginesów. Proces ten jest kontynuowany do momentu, gdy wszystkie marginesy będą wolne od komórek nowotworowych³⁴.

Zabieg Mohsa jest szczególnie zalecany w przypadku guzów zlokalizowanych w miejscach, gdzie zachowanie zdrowej tkanki jest kluczowe ze względów funkcjonalnych i estetycznych, jak powieki czy twarz⁵. Metoda ta wykazuje znacząco niższe wskaźniki nawrotów miejscowych (około 11%) i przerzutów regionalnych (6-8%) w porównaniu do szerokiego wycięcia miejscowego⁶. Badania wykazały, że 16 z 18 pacjentów poddanych chirurgii Mohsa z powodu raka sebacytowego pozostało wolnych od choroby po średnim okresie obserwacji wynoszącym 37 miesięcy⁷.

Szerokie wycięcie miejscowe

Przed wprowadzeniem chirurgii Mohsa, szerokie wycięcie miejscowe (Wide Local Excision – WLE) było podstawową metodą leczenia raka sebacytowego⁸. Technika ta polega na usunięciu całego guza wraz z marginesem zdrowej tkanki (zwykle 5-6 mm)⁹¹⁰.

Chociaż metoda ta jest nadal stosowana, wiąże się z wyższym ryzykiem nawrotu choroby. Marginesy 5-6 mm są związane z 5-letnią śmiertelnością na poziomie 18% oraz wskaźnikami nawrotu sięgającymi 30-37% w ciągu 5 lat, z przerzutami regionalnymi występującymi w 28% przypadków¹¹.

Pełna ocena obwodowych i głębokich marginesów

Złotym standardem techniki chirurgicznej w leczeniu raka sebacytowego jest pełna ocena obwodowych i głębokich marginesów (Complete Circumferential Peripheral and Deep Margin Assessment – CCPDMA), która obejmuje chirurgię mikrograficzną Mohsa oraz technikę Tübingen torte¹²¹³.

W przypadku pełnościennego zajęcia powiek wymagane jest wycięcie pełnej grubości powieki z oceną marginesów w badaniu doraźnym. W przypadku rozległego zajęcia górnej i dolnej powieki może być konieczna egzenteracja oczodołu¹⁴.

Chirurgia rekonstrukcyjna

Po usunięciu guza, zwłaszcza w przypadku nowotworów zlokalizowanych na powiekach lub w innych wrażliwych obszarach twarzy, często konieczna jest chirurgia rekonstrukcyjna. Zabieg ten zazwyczaj wykonywany jest bezpośrednio po usunięciu nowotworu¹⁵¹⁶.

Celem chirurgii rekonstrukcyjnej jest przywrócenie funkcji i wyglądu zajętego obszaru, co ma szczególne znaczenie w przypadku lokalizacji oczodołowej¹⁷.

Radioterapia w leczeniu raka sebacytowego

Radioterapia nie jest leczeniem pierwszego wyboru w raku sebacytowym, jednak znajduje zastosowanie w określonych sytuacjach klinicznych¹⁸¹⁹.

Wskazania do radioterapii

Radioterapia w raku sebacytowym może być rozważana w następujących sytuacjach:

Leczenie pacjentów, którzy nie kwalifikują się do leczenia chirurgicznego lub odmawiają operacji²⁰²¹
Leczenie uzupełniające po operacji w przypadku dodatnich marginesów chirurgicznych, niekompletnej resekcji lub naciekania okołonerwowego²²
Leczenie pacjentów z przerzutami do węzłów chłonnych (jako alternatywa dla całkowitego usunięcia węzłów)²³
Leczenie paliatywne w celu złagodzenia objawów w przypadku rozsiewu choroby²⁴²⁵

Radioterapia uzupełniająca

Radioterapia pooperacyjna jest zalecana w przypadku guzów T3 (według klasyfikacji AJCC, 7. edycja) po egzenteracji oczodołu, co znacząco zmniejsza ryzyko nawrotu choroby²⁶. Radioterapia regionalna jest również preferowana w stosunku do całkowitego usunięcia węzłów chłonnych u pacjentów z dodatnim wynikiem biopsji węzła wartowniczego, po limfadenektomii, z potwierdzonymi przerzutami do węzłów chłonnych lub wymagających leczenia paliatywnego²⁷.

Opisano przypadek pacjenta, który przeszedł egzenterację oczodołu, a następnie otrzymał uzupełniającą radioterapię z powodu marginesu tkanek miękkich mniejszego niż 1 mm i zaawansowanego stadium T. Takie podejście okazało się skuteczne w zapobieganiu nawrotom choroby²⁸²⁹.

Brachyterapia

Brachyterapia jest jedną z form radioterapii, która okazała się skuteczną metodą leczenia oczodołowego raka sebacytowego³⁰. Metoda ta polega na umieszczeniu źródła promieniowania bezpośrednio w pobliżu lub wewnątrz guza, co pozwala na dostarczenie wysokiej dawki promieniowania do nowotworu przy jednoczesnym minimalizowaniu ekspozycji zdrowych tkanek.

Inne metody leczenia raka sebacytowego

Krioterapia

Krioterapia to metoda leczenia polegająca na zamrażaniu tkanek, co prowadzi do zniszczenia komórek nowotworowych. W przypadku raka sebacytowego, krioterapia może być stosowana w wybranych przypadkach, szczególnie przy pagetoidalnym rozroście nowotworu do spojówki lub rogówki³¹³².

Jednak metoda ta wymaga dalszych badań w celu oceny jej skuteczności w leczeniu raka sebacytowego³³. Należy zauważyć, że techniki destrukcyjne, takie jak elektrodezsekcja i łyżeczkowanie, nie są zalecane ze względu na skłonność do nawrotów lub przerzutów³⁴.

Leki miejscowe

W przypadku pozytywnych marginesów spojówkowych lub nawrotów spojówkowych po chirurgii Mohsa, można rozważyć zastosowanie mitomycyny C miejscowo lub krioterapii³⁵. Mitomycyna C jest lekiem przeciwnowotworowym, który podany miejscowo może poprawić wyniki leczenia w przypadku dodatnich marginesów spojówkowych lub w przypadku nawrotu spojówkowego³⁶.

Leczenie systemowe i terapie celowane

W przypadku nieoperacyjnego raka sebacytowego lub choroby przerzutowej można rozważyć zastosowanie terapii systemowych, w tym immunoterapii lub terapii celowanych, takich jak antyandrogeny, ligandy receptorów retinoidowych i inhibitory receptora naskórkowego czynnika wzrostu (EGFR)³⁷.

Opisano przypadek pacjenta z rakiem sebacytowym z przerzutami do płuc, który uzyskał całkowitą odpowiedź kliniczną i radiologiczną po zastosowaniu kombinacji paklitakselu i karboplatyny. Pacjent pozostawał wolny od choroby przez 6 miesięcy po zakończeniu leczenia, co sugeruje, że chemioterapia może być dobrą opcją w leczeniu raka sebacytowego z przerzutami³⁸.

Immunoterapia

Inhibitory punktów kontrolnych immunologicznych, takie jak pembrolizumab, wykazują obiecujące wyniki w leczeniu raka sebacytowego. Raportowano przypadek pacjenta z rozsianym rakiem sebacytowym, który uzyskał znaczącą odpowiedź kliniczną i radiograficzną na leczenie pembrolizumabem. Odpowiedź ta była związana z obecnością krążących pamięciowych limfocytów T i dojrzałych komórek NK we krwi obwodowej po 6 miesiącach terapii³⁹.

Badania sugerują, że ekspresja PD-L1 może być najważniejszym biomarkerem przewidującym korzyść z terapii anty-PD1 w raku sebacytowym, niezależnie od statusu niestabilności mikrosatelitarnej (MSI)⁴⁰.

Leczenie zaawansowanego i przerzutowego raka sebacytowego

Egzenteracja oczodołu

W przypadku rozległego zajęcia powiek lub naciekania tkanek oczodołu przez raka sebacytowego, może być konieczna egzenteracja oczodołu (usunięcie zawartości oczodołu)⁴¹. Jest to radykalna procedura, która jest zazwyczaj zarezerwowana dla leczenia rozległego raka sebacytowego lub guzów, które naciąły tkanki miękkie oczodołu i postępują mimo innych metod leczenia⁴².

W rzadkich przypadkach, gdy nowotwór znacząco rozprzestrzenił się do oka, może być konieczne usunięcie gałki ocznej i otaczających tkanek⁴³.

Leczenie przerzutów do węzłów chłonnych

W przypadku przerzutów do regionalnych węzłów chłonnych, możliwe jest chirurgiczne usunięcie zajętych węzłów⁴⁴⁴⁵. Biopsja węzła wartowniczego może być rozważana w przypadku guzów okołooczodołowych w stadium T2c lub wyższym⁴⁶.

Radioterapia regionalna jest alternatywą dla całkowitego usunięcia węzłów chłonnych u pacjentów z dodatnim wynikiem biopsji węzła wartowniczego, po limfadenektomii lub z potwierdzonymi przerzutami do węzłów chłonnych⁴⁷.

Chemioterapia w chorobie przerzutowej

Leczenie choroby przerzutowej ma zazwyczaj charakter paliatywny i ma na celu kontrolę objawów oraz poprawę jakości życia pacjenta⁴⁸. Chemioterapia jest jedną z opcji w leczeniu zaawansowanego raka sebacytowego.

Opisano przypadek całkowitej remisji przerzutów do płuc po zastosowaniu kombinacji paklitakselu i karboplatyny, co sugeruje, że nowe schematy chemioterapii mogą być obiecującą opcją leczenia raka sebacytowego z przerzutami⁴⁹.

Badania kliniczne i nowe kierunki leczenia

Pacjenci z rakiem sebacytowym mogą być zachęcani do udziału w badaniach klinicznych, które mają na celu ocenę nowych metod leczenia lub nowych sposobów podejścia do leczenia tej choroby⁵⁰⁵¹.

Nowe obiecujące kierunki leczenia raka sebacytowego obejmują:

Immunoterapię z zastosowaniem inhibitorów punktów kontrolnych, takich jak pembrolizumab⁵²⁵³
Terapie celowane, w tym inhibitory EGFR⁵⁴
Neoadjuwantową chemioterapię w celu zmniejszenia wielkości guza przed operacją⁵⁵
Terapię redukującą guz (chemoredukcję), która wydaje się obiecującą metodą leczenia⁵⁶

Prognoza i obserwacja po leczeniu

Wskaźniki przeżycia

Rak sebacytowy jest agresywnym nowotworem, jednak przy wczesnym wykryciu i odpowiednim leczeniu, rokowanie jest dobre. Ponad 90% pacjentów poddanych leczeniu przeżywa chorobę⁵⁷.

5-letni względny wskaźnik przeżycia dla pacjentów z zlokalizowanym rakiem sebacytowym wynosi około 78%. Wskaźnik ten spada do około 50% w przypadku choroby rozsianej⁵⁸.

Nawroty i obserwacja

Rak sebacytowy charakteryzuje się stosunkowo wysokim ryzykiem nawrotu. U nawet 25% pacjentów nowotwór może powrócić lub dać przerzuty po leczeniu⁵⁹. Zgłaszane wskaźniki nawrotów węzłowych wynoszą 8-23%, a przerzutów odległych 2-14%⁶⁰.

Ze względu na agresywny charakter choroby i ryzyko nawrotu, pacjenci po leczeniu raka sebacytowego wymagają ścisłej obserwacji. Zaleca się regularne wizyty kontrolne, które powinny być kontynuowane przez co najmniej 3-5 lat⁶¹⁶².

Wczesne wykrycie nawrotu choroby umożliwia szybkie wdrożenie odpowiedniego leczenia, co zwiększa szanse na korzystny wynik⁶³⁶⁴.

Podsumowanie podejścia terapeutycznego

Leczenie raka sebacytowego wymaga podejścia wielodyscyplinarnego, uwzględniającego specjalistów z dziedziny dermatologii, chirurgii plastycznej i onkologii radiacyjnej⁶⁵.

Podstawową metodą leczenia jest chirurgiczne usunięcie guza, z preferencją dla chirurgii mikrograficznej Mohsa, szczególnie w przypadku lokalizacji w obrębie powiek lub twarzy⁶⁶.

Radioterapia jest zarezerwowana dla przypadków, gdy leczenie chirurgiczne nie jest możliwe, jako leczenie uzupełniające po operacji lub w przypadku choroby przerzutowej⁶⁷.

Nowe obiecujące metody leczenia, w tym immunoterapia i terapie celowane, są przedmiotem badań klinicznych i mogą w przyszłości poprawić wyniki leczenia pacjentów z rakiem sebacytowym⁶⁸.

Ze względu na agresywny charakter choroby i ryzyko nawrotu, kluczowe znaczenie ma wczesne rozpoznanie i leczenie oraz regularna obserwacja po zakończeniu terapii⁶⁹⁷⁰.

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Materiały źródłowe

#1 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Historically, wide local excision (WLE) was the mainstay of treatment for sebaceous carcinoma. However, recent developments advocate Mohs micrographic surgery (MMS) as a more favorable option. MMS ensures clear margins before reconstruction and proves particularly attractive in the treatment of this tumor, allowing for tissue conservation in cosmetically sensitive areas and potentially lowering recurrence rates. […] The gold standard technique for sebaceous carcinoma treatment is complete circumferential peripheral and deep margin assessment (CCPDMA), which includes MMS and the Tubingen torte technique. Sebaceous carcinomas may also be treated with WLE. Excision margins of 5 to 6 mm are commonly regarded as standard. However, these margins have been linked to a 5-year mortality rate of 18% and recurrence rates of up to 30% to 37% within 5 years, with regional metastases occurring in 28% of cases.
#2 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#3 Sebaceous carcinoma – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/sebaceous-carcinoma/diagnosis-treatment/drc-20577655
Sebaceous carcinoma treatment often involves surgery to remove the cancer. Other treatments might be options in certain situations. […] Treatment options may include: […] Surgery to remove the cancer. Your healthcare professional may recommend a procedure to remove the cancer and some of the healthy tissue that surrounds it. A specialist will examine the edges of the tissue to make sure no cancer cells are present. This makes it more likely that all of the cancer cells are removed during surgery. […] Mohs surgery. Mohs surgery is a specialized type of surgery that involves removing thin layers of cancer-containing skin until only cancer-free tissue is left. After each layer of skin is removed, it’s checked for signs of cancer. The process keeps going until there are no signs of cancer. This technique may be helpful if your cancer is in a spot where surgeons want to preserve as much of the healthy skin as possible. Examples include the eyelid and the face.
#4 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
How is sebaceous carcinoma treated? […] Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC: […] Excision: During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. This helps to remove cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells. […] Mohs surgery: Because many SCs develop on an eyelid or other area with little extra skin, Mohs (pronounced „moes”) surgery may be recommended. This specialized surgery is only used to treat skin cancer. This surgery allows the Mohs surgeon to remove less tissue yet remove the entire tumor. […] After the cancer surgery, some patients need reconstructive surgery. This surgery is often performed immediately after the cancer surgery.
#5 Sebaceous Carcinoma | Roswell Park Comprehensive Cancer Center – Buffalo, NY
https://www.roswellpark.org/cancer/skin/what-skin-cancer/sebaceous-carcinoma
Sebaceous carcinoma is a rare and aggressive type of skin cancer that develops in a sebaceous gland, which produces sebum, a mixture of complex oils that help to lubricate the skin. […] The primary treatment for sebaceous carcinoma is surgery, which may include one of the following procedures: Wide excision. With excision surgery, your surgeon removes the entire tumor and some surrounding healthy tissue to ensure that all the cancer is removed. […] Mohs micrographic surgery. This specialized type of skin cancer surgery requires the expertise of a dermatologist trained in Mohs surgery. During Mohs surgery, the surgeon removes affected tissue one layer at a time, examining each under a microscope. The process continues until no cancer cells are found. […] After surgery, some patients may need plastic and reconstructive surgery (especially if the cancer was on the eyelid) to restore function and appearance. […] Survival rate is high among patients whose sebaceous carcinoma is detected and treated at an early stage. However, sebaceous carcinoma is considered somewhat aggressive, and it can recur after treatment. For these reasons, it is important that patients follow up with their doctors as scheduled.
#6 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Since sebaceous carcinoma predominantly occurs on the head or neck in 70% of cases, it necessitates a tissue-preserving surgical approach. MMS for sebaceous carcinoma exhibits significantly lower local recurrence rates (11%) and regional metastases (6%-8%) than WLE. MMS may also gain preference due to shorter healing times and minimal scar formation, increasing patient satisfaction. […] Destructive techniques, such as electrodesiccation and curettage, are discouraged due to the propensity for relapse or metastasis. Incomplete removal of the primary tumor poses a significant concern, as do other high-risk factors like comorbidities, advanced age, and the primary site influencing overall survival. Radiation and systemic therapy have become a recommended alternative for nonsurgical candidates, with adjuvant indications for positive margins, incomplete excision, or perineural invasion.
#7 Sebaceous carcinoma: Symptoms, causes, treatments, and more
https://www.medicalnewstoday.com/articles/sebaceous-carcinoma
Sebaceous carcinoma is a rare and aggressive skin cancer. It typically begins on a persons eyelid. If doctors find it early, they can often treat it successfully with surgery. […] Doctors may treat sebaceous carcinoma with surgery or other methods. […] Mohs surgery is a specialized technique for areas with little skin, such as the eyelids. […] One study found that 16 out of 18 people who had Mohs surgery for sebaceous carcinoma were cancer-free after an average follow-up of 37 months. […] Other treatments for sebaceous carcinoma can include cryotherapy, which involves removing areas of skin by freezing it. […] Radiation therapy is not a first-line treatment for sebaceous carcinoma, but may be a suitable option if: a person cannot have surgery or would prefer not to; the cancer has spread; some cancer remains after surgery.
#8 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Historically, wide local excision (WLE) was the mainstay of treatment for sebaceous carcinoma. However, recent developments advocate Mohs micrographic surgery (MMS) as a more favorable option. MMS ensures clear margins before reconstruction and proves particularly attractive in the treatment of this tumor, allowing for tissue conservation in cosmetically sensitive areas and potentially lowering recurrence rates. […] The gold standard technique for sebaceous carcinoma treatment is complete circumferential peripheral and deep margin assessment (CCPDMA), which includes MMS and the Tubingen torte technique. Sebaceous carcinomas may also be treated with WLE. Excision margins of 5 to 6 mm are commonly regarded as standard. However, these margins have been linked to a 5-year mortality rate of 18% and recurrence rates of up to 30% to 37% within 5 years, with regional metastases occurring in 28% of cases.
#9 Sebaceous Carcinoma | Cancer Care and Oncology | Bon Secours
https://www.bonsecours.com/health-care-services/cancer-care-oncology/conditions/sebaceous-carcinoma
Treatment for sebaceous carcinoma typically involves surgery, chemotherapy and/or radiation therapy. […] Depending on your personal health history, the extent of your sebaceous carcinoma and other factors, your oncologist may recommend one or more of the following treatment options: […] Surgery – your doctor will likely recommend a surgical procedure to remove the cancerous area, along with a margin of healthy tissue. One type of procedure known as Mohs surgery involves removing thin layers of tissue and then examining them under a microscope until no cancerous cells remain in the sample. […] Chemotherapy – this treatment involves the use of medications to destroy cancer cells. Chemotherapy drugs can be delivered orally (a pill taken by mouth) or an intravenous, or IV, liquid (injected into a vein). You may need to undergo chemotherapy after surgery so that your doctor can destroy any cancerous cells that couldnt be removed surgically or if the cancer has spread beyond the original area. […] Radiation therapy – this treatment uses high-powered energy beams to destroy cancerous cells. You may need to undergo radiation therapy to destroy any cancerous cells that couldnt be removed surgically or if the cancer has spread beyond the original area.
#10 Sebaceous Carcinoma Treatment – Baton Rouge Dermatologist
https://batonrougedermatologist.com/skincancer/sebaceous-carcinoma/
How is Sebaceous Carcinoma treated? […] The arsenal of treatments for sebaceous carcinoma encompasses diverse strategies tailored to the individualâs condition. […] Surgical avenues take the forefront: […] Wide Local Excision: A meticulous procedure that removes the tumor and a normal tissue margin. This helps ensure the cancerâs thorough elimination. […] Mohs Surgery: Employing a staged approach, Mohs surgery incrementally removes the cancerous tumor and surrounding healthy tissue. During the procedure, thin slices of tissue are examined to gauge the need for further excision, guaranteeing complete eradication of cancer cells. […] Radiation Therapy: Reserved for cases where surgery isnât feasible, radiation therapy targets the cancer cells with high-energy rays, inhibiting their growth and division. […] Yes. At our Baton Rouge dermatology office we offer treatment for Sebaceous Carcinoma to patients from Baton Rouge and the surrounding area. Contact our office today to schedule an appointment.
#11 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Historically, wide local excision (WLE) was the mainstay of treatment for sebaceous carcinoma. However, recent developments advocate Mohs micrographic surgery (MMS) as a more favorable option. MMS ensures clear margins before reconstruction and proves particularly attractive in the treatment of this tumor, allowing for tissue conservation in cosmetically sensitive areas and potentially lowering recurrence rates. […] The gold standard technique for sebaceous carcinoma treatment is complete circumferential peripheral and deep margin assessment (CCPDMA), which includes MMS and the Tubingen torte technique. Sebaceous carcinomas may also be treated with WLE. Excision margins of 5 to 6 mm are commonly regarded as standard. However, these margins have been linked to a 5-year mortality rate of 18% and recurrence rates of up to 30% to 37% within 5 years, with regional metastases occurring in 28% of cases.
#12 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Historically, wide local excision (WLE) was the mainstay of treatment for sebaceous carcinoma. However, recent developments advocate Mohs micrographic surgery (MMS) as a more favorable option. MMS ensures clear margins before reconstruction and proves particularly attractive in the treatment of this tumor, allowing for tissue conservation in cosmetically sensitive areas and potentially lowering recurrence rates. […] The gold standard technique for sebaceous carcinoma treatment is complete circumferential peripheral and deep margin assessment (CCPDMA), which includes MMS and the Tubingen torte technique. Sebaceous carcinomas may also be treated with WLE. Excision margins of 5 to 6 mm are commonly regarded as standard. However, these margins have been linked to a 5-year mortality rate of 18% and recurrence rates of up to 30% to 37% within 5 years, with regional metastases occurring in 28% of cases.
#13 Sebaceous Carcinoma – EyeWiki
https://eyewiki.org/Sebaceous_Carcinoma
Sebaceous carcinoma is a rare, highly malignant, and potentially lethal tumor of the skin, which most commonly occurs in the eyelid. […] The mainstay of treatment is surgical excision. It is important to ensure a full thickness specimen, and to consider obtaining map biopsies of the conjunctiva. If invasive, orbital exenteration may be indicated. […] Mohs micrographic surgery or complete circumferential peripheral and deep margin assessment (CCPDMA) are first line treatments for sebaceous carcinoma. […] Topical mitomycin or cryotherapy may improve outcomes where positive conjunctival margins exist, or in the setting of conjunctival recurrence after repeat Mohs or CCPDMA or pagetoid spread. […] Wide local excision may also be considered in some cases. When sebaceous cell carcinoma invades the orbit, exenteration may be considered. […] Sentinel lymph node biopsies can be considered for periocular tumors Stage T2c or higher. […] Sebaceous carcinoma prognosis relies on several factors, including size, location, treatment approach, and tumor stage.
#14 Sebaceous Gland Carcinoma Treatment & Management: Surgical Therapy, Follow-up, Complications
https://emedicine.medscape.com/article/1213781-treatment
Treatment aims to remove the malignant lesion to prevent local or systemic spread. The treatment of sebaceous gland carcinoma is adequate surgical excision, with wide surgical margins and fresh frozen section controls to delineate the tumor edges. Lymph node evaluation is necessary to evaluate metastasis. […] If diffuse involvement of the upper and lower eyelids is present, exenteration is required. Obtain a biopsy specimen of the areas of reddening of the conjunctiva that are suggestive of sebaceous gland carcinoma at the time of surgery. […] Local surgical excision of the tumor as initial treatment was performed in 25 patients. Exenteration was the initial surgery performed in 4 patients. […] With wide excision and no evidence of metastasis, surgery results in a cure for the malignancies. However, sebaceous lesions have a high incidence of recurrence and metastasis.
#15 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
How is sebaceous carcinoma treated? […] Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC: […] Excision: During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. This helps to remove cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells. […] Mohs surgery: Because many SCs develop on an eyelid or other area with little extra skin, Mohs (pronounced „moes”) surgery may be recommended. This specialized surgery is only used to treat skin cancer. This surgery allows the Mohs surgeon to remove less tissue yet remove the entire tumor. […] After the cancer surgery, some patients need reconstructive surgery. This surgery is often performed immediately after the cancer surgery.
#16 Sebaceous carcinoma: Foothill Dermatology Medical Center: Dermatology
https://www.foothillderm.com/blog/sebaceous-carcinoma
Sebaceous carcinoma (SC) is a rare skin cancer. It is considered an aggressive skin cancer because it can spread. […] Found early and treated, treatment is often successful. […] The sooner this cancer is diagnosed and treated the better the outcome. If SC spreads, it can be deadly. […] If SC is suspected, you also will need a thorough physical exam, a thorough eye exam, and other medical tests. […] Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC: Excision and Mohs surgery. […] After the cancer surgery, some patients need reconstructive surgery. This surgery is often performed immediately after the cancer surgery. […] Radiation is not the first choice for treating SC. This treatment may be an option for easing a patient’s pain if the cancer has spread, treating patients who refuse or cannot withstand surgery, or treating patients who have had surgery but may still have some cancer.
#17 Sebaceous Carcinoma | Roswell Park Comprehensive Cancer Center – Buffalo, NY
https://www.roswellpark.org/cancer/skin/what-skin-cancer/sebaceous-carcinoma
Sebaceous carcinoma is a rare and aggressive type of skin cancer that develops in a sebaceous gland, which produces sebum, a mixture of complex oils that help to lubricate the skin. […] The primary treatment for sebaceous carcinoma is surgery, which may include one of the following procedures: Wide excision. With excision surgery, your surgeon removes the entire tumor and some surrounding healthy tissue to ensure that all the cancer is removed. […] Mohs micrographic surgery. This specialized type of skin cancer surgery requires the expertise of a dermatologist trained in Mohs surgery. During Mohs surgery, the surgeon removes affected tissue one layer at a time, examining each under a microscope. The process continues until no cancer cells are found. […] After surgery, some patients may need plastic and reconstructive surgery (especially if the cancer was on the eyelid) to restore function and appearance. […] Survival rate is high among patients whose sebaceous carcinoma is detected and treated at an early stage. However, sebaceous carcinoma is considered somewhat aggressive, and it can recur after treatment. For these reasons, it is important that patients follow up with their doctors as scheduled.
#18 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#19 Sebaceous carcinoma – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/sebaceous-carcinoma/diagnosis-treatment/drc-20577655
Radiation therapy. Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. Radiation therapy can be used after surgery to kill any cancer cells that might remain. Radiation therapy may be used alone if surgery isn’t an option. […] Clinical trials. Clinical trials to test new treatments may be an option. Ask your healthcare professional whether you’re eligible to participate in a clinical trial.
#20 Sebaceous gland carcinoma | Skin cancer | Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/skin-cancer/types/sebaceous-gland-carcinoma
You should have treatment at a specialist skin cancer centre because this is a rare type of skin cancer. A team of doctors discuss the best treatment and care for you. They are called a multidisciplinary team (MDT). The MDT includes a skin specialist (dermatologist), a plastic surgeon and a cancer radiotherapy specialist (clinical oncologist). […] The main treatments for sebaceous gland carcinoma are: surgery, radiotherapy. […] Surgery is the main treatment. Your surgeon aims to remove all the cancer cells and some healthy tissue around it (a healthy margin). […] Radiotherapy means the use of radiation, usually x-rays, to kill cancer cells. You might have it: after surgery to kill any cancer cells that might have been left behind – this is called adjuvant treatment, as your only treatment if you cant have surgery for any reason. […] Treatment for cancer that has spread to other parts of the body wont get rid of the cancer. But it can control your symptoms and help you feel better. You might have chemotherapy. Your doctor might offer you treatment as part of a clinical trial.
#21 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#22 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Since sebaceous carcinoma predominantly occurs on the head or neck in 70% of cases, it necessitates a tissue-preserving surgical approach. MMS for sebaceous carcinoma exhibits significantly lower local recurrence rates (11%) and regional metastases (6%-8%) than WLE. MMS may also gain preference due to shorter healing times and minimal scar formation, increasing patient satisfaction. […] Destructive techniques, such as electrodesiccation and curettage, are discouraged due to the propensity for relapse or metastasis. Incomplete removal of the primary tumor poses a significant concern, as do other high-risk factors like comorbidities, advanced age, and the primary site influencing overall survival. Radiation and systemic therapy have become a recommended alternative for nonsurgical candidates, with adjuvant indications for positive margins, incomplete excision, or perineural invasion.
#23 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Regional radiotherapy is also preferred over complete node dissection in patients who have positive sentinel lymph node biopsy results, are status post lymphadenectomy, show evidence of nodal metastasis, or require palliative treatment. Systemic therapies for the management of unresectable sebaceous carcinoma include immunotherapies or targeted therapies such as antiandrogens, retinoid receptor ligands, and epidermal growth factor receptor inhibitors.
#24 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#25 Sebaceous carcinoma: Symptoms, causes, treatments, and more
https://www.medicalnewstoday.com/articles/sebaceous-carcinoma
Sebaceous carcinoma is a rare and aggressive skin cancer. It typically begins on a persons eyelid. If doctors find it early, they can often treat it successfully with surgery. […] Doctors may treat sebaceous carcinoma with surgery or other methods. […] Mohs surgery is a specialized technique for areas with little skin, such as the eyelids. […] One study found that 16 out of 18 people who had Mohs surgery for sebaceous carcinoma were cancer-free after an average follow-up of 37 months. […] Other treatments for sebaceous carcinoma can include cryotherapy, which involves removing areas of skin by freezing it. […] Radiation therapy is not a first-line treatment for sebaceous carcinoma, but may be a suitable option if: a person cannot have surgery or would prefer not to; the cancer has spread; some cancer remains after surgery.
#26 Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma | BMC Ophthalmology | Full Text
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01367-3
Mohs surgery has been recommended as treatment of sebaceous carcinoma with excellent results with 11% recurrence rate for primary tumours. […] Good results have also been published using frozen sections and therefore many authors prefer it. […] Postoperative radiation after exenteration in T3 tumors (AJCC 7-th edition) is reported to significantly reduce the risk of recurrent disease. […] Radiation has also been recommended for recurrent disease after exenteration and postoperatively if insufficient margins or perineural spread is detected. […] Exenteration should be considered if there is extensive growth in the orbit or recurrent orbital disease after globe sparing surgery. […] The follow-up was only 18months, but chemoreduction seems probably a promising treatment method. […] The length of follow-up is debatable. Many studies report 5 years or longer follow-up. […] The reported rates for nodal recurrences are 8-23% and for distant metastasis 2-14%. […] In our study most respondents used a 5-year follow-up, which in the light of published studies seems a justified minimum follow-up time.
#27 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Regional radiotherapy is also preferred over complete node dissection in patients who have positive sentinel lymph node biopsy results, are status post lymphadenectomy, show evidence of nodal metastasis, or require palliative treatment. Systemic therapies for the management of unresectable sebaceous carcinoma include immunotherapies or targeted therapies such as antiandrogens, retinoid receptor ligands, and epidermal growth factor receptor inhibitors.
#28 Adjuvant radiotherapy for sebaceous carcinoma of the eyelid after orbital exenteration – Huang – Therapeutic Radiology and Oncology
https://tro.amegroups.org/article/view/5120/html
Surgical excision is an optimal treatment option for sebaceous carcinoma of the orbital region. […] Adjuvant radiotherapy is suggested to patients with adverse pathological findings. […] The patient underwent orbital exenteration as a radical treatment approach. […] Postoperatively, the patient was administered adjuvant radiotherapy owing to a less than 1mm deep soft tissue margin and advanced T stage. […] This successful treatment response indicates that surgical intervention and adjuvant radiotherapy with appropriate doses could be considered in patients with sebaceous carcinoma of the eyelid. […] Subsequently, postoperative radiotherapy is suggested for those displaying adverse pathological features such as lymphovascular permeation, perineural invasion, and involved margins. […] Considering the irreversibility of the left eye function, organ preservation was of little significance to the patient himself; instead, he preferred a treatment that would minimize the chances of future recurrences.
#29 Adjuvant radiotherapy for sebaceous carcinoma of the eyelid after orbital exenteration – Huang – Therapeutic Radiology and Oncology
https://tro.amegroups.org/article/view/5120/html
Accordingly, the patient was suggested orbital exenteration combined with postoperative radiotherapy to enhance the local control of the disease. […] Therefore, the radical treatment approach of orbital exenteration followed by adjuvant radiotherapy was performed. […] This report reveals that the combination of a radical surgical approach and postoperative adjuvant radiotherapy could be a satisfactory and safe treatment approach in patients with recurrent locally advanced sebaceous carcinoma of the eyelid.
#30 Recent updates on the management of ocular sebaceous gland carcinoma – IJOOO
https://www.ijooo.org/html-article/19462
Mohs micrographic surgery consists of removal and extemporaneous analysis of every skin stratum until the identification of disease-free margins. […] Topical and systemic chemotherapy can be useful in SGC for the reduction of tumor size and prevention of micrometastasis. […] Recently systemic Chemotherapy has been recommended for patients with metastatic or locally advanced periocular SGC. […] Radiation therapy, especially brachytherapy, has been proven as an efficient treatment of ocular SGC. […] Cryotherapy has a certain effect on ocular SGC with pagetoid spread to the conjunctiva or cornea. […] In recent years, targeted therapy is having an emerging role in the treatment of refractory tumors such as advanced melanoma. […] Orbital exenteration is usually reserved for the treatment of extensive SGC or those tumours that have invaded the orbital soft tissue and are relentlessly progressive despite other treatments.
#31 Recent updates on the management of ocular sebaceous gland carcinoma – IJOOO
https://www.ijooo.org/html-article/19462
Mohs micrographic surgery consists of removal and extemporaneous analysis of every skin stratum until the identification of disease-free margins. […] Topical and systemic chemotherapy can be useful in SGC for the reduction of tumor size and prevention of micrometastasis. […] Recently systemic Chemotherapy has been recommended for patients with metastatic or locally advanced periocular SGC. […] Radiation therapy, especially brachytherapy, has been proven as an efficient treatment of ocular SGC. […] Cryotherapy has a certain effect on ocular SGC with pagetoid spread to the conjunctiva or cornea. […] In recent years, targeted therapy is having an emerging role in the treatment of refractory tumors such as advanced melanoma. […] Orbital exenteration is usually reserved for the treatment of extensive SGC or those tumours that have invaded the orbital soft tissue and are relentlessly progressive despite other treatments.
#32 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#33 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#34 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Since sebaceous carcinoma predominantly occurs on the head or neck in 70% of cases, it necessitates a tissue-preserving surgical approach. MMS for sebaceous carcinoma exhibits significantly lower local recurrence rates (11%) and regional metastases (6%-8%) than WLE. MMS may also gain preference due to shorter healing times and minimal scar formation, increasing patient satisfaction. […] Destructive techniques, such as electrodesiccation and curettage, are discouraged due to the propensity for relapse or metastasis. Incomplete removal of the primary tumor poses a significant concern, as do other high-risk factors like comorbidities, advanced age, and the primary site influencing overall survival. Radiation and systemic therapy have become a recommended alternative for nonsurgical candidates, with adjuvant indications for positive margins, incomplete excision, or perineural invasion.
#35 Sebaceous Carcinoma – EyeWiki
https://eyewiki.org/Sebaceous_Carcinoma
Sebaceous carcinoma is a rare, highly malignant, and potentially lethal tumor of the skin, which most commonly occurs in the eyelid. […] The mainstay of treatment is surgical excision. It is important to ensure a full thickness specimen, and to consider obtaining map biopsies of the conjunctiva. If invasive, orbital exenteration may be indicated. […] Mohs micrographic surgery or complete circumferential peripheral and deep margin assessment (CCPDMA) are first line treatments for sebaceous carcinoma. […] Topical mitomycin or cryotherapy may improve outcomes where positive conjunctival margins exist, or in the setting of conjunctival recurrence after repeat Mohs or CCPDMA or pagetoid spread. […] Wide local excision may also be considered in some cases. When sebaceous cell carcinoma invades the orbit, exenteration may be considered. […] Sentinel lymph node biopsies can be considered for periocular tumors Stage T2c or higher. […] Sebaceous carcinoma prognosis relies on several factors, including size, location, treatment approach, and tumor stage.
#36 Sebaceous carcinoma: Symptoms, causes, treatments, and more
https://www.medicalnewstoday.com/articles/sebaceous-carcinoma
Sebaceous carcinoma is a rare and aggressive skin cancer. It typically begins on a persons eyelid. If doctors find it early, they can often treat it successfully with surgery. […] Doctors may treat sebaceous carcinoma with surgery or other methods. […] Mohs surgery is a specialized technique for areas with little skin, such as the eyelids. […] One study found that 16 out of 18 people who had Mohs surgery for sebaceous carcinoma were cancer-free after an average follow-up of 37 months. […] Other treatments for sebaceous carcinoma can include cryotherapy, which involves removing areas of skin by freezing it. […] Radiation therapy is not a first-line treatment for sebaceous carcinoma, but may be a suitable option if: a person cannot have surgery or would prefer not to; the cancer has spread; some cancer remains after surgery.
#37 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Regional radiotherapy is also preferred over complete node dissection in patients who have positive sentinel lymph node biopsy results, are status post lymphadenectomy, show evidence of nodal metastasis, or require palliative treatment. Systemic therapies for the management of unresectable sebaceous carcinoma include immunotherapies or targeted therapies such as antiandrogens, retinoid receptor ligands, and epidermal growth factor receptor inhibitors.
#38 Sebaceous carcinoma and systemic chemotherapy
https://pmc.ncbi.nlm.nih.gov/articles/PMC3618649/
Sebaceous gland carcinoma is a rare malignant tumor, which arises from the adnexal epithelium of sebaceous glands. […] Role of chemotherapy in the management of metastatic sebaceous carcinoma is evolving. Combination chemotherapy can result in long term remission as described in this case report. […] The mainstay of treatment of SC is surgical excision. For regional and metastatic disease, radiation, and chemotherapeutic drugs have been used with varying degrees of response. […] Our case report is the first in literature, in which patients had complete clinicoradiological response with combination of paclitaxel and carboplatin for lung metastasis. This shows that chemotherapy can be a good option in treatment of sebaceous carcinoma with metastasis as our patient showed complete remission of lung metastasis and was disease free after 6 months of treatment. […] New chemotherapeutic regimens need to be evaluated in treatment of sebaceous carcinoma as our case report has shown combination of carboplatin and paclitaxel as a promising treatment option.
#39 Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma | Journal for ImmunoTherapy of Cancer | Full Text
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0357-3
Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck. […] Optimal treatment of metastatic sebaceous malignancy has not been firmly established. To date, treatment approaches have been adapted from regimens used to treat head and neck cancers, with several retrospective series showing effectiveness of multi-agent cisplatin-based chemotherapy. […] While the sporadic form of SC is not generally associated with mutations in DNA mismatch repair genes, cases associated with Muir-Torre and microsatellite instability (MSI) are likely to respond to immunotherapy. […] Anti-PD1 checkpoint inhibitors are approved for malignant melanoma and merkel cell carcinoma, a polyomavirus associated skin adnexal tumor. […] This is the first report describing objective clinical and radiographic responses following immunotherapy for widely metastatic sebaceous carcinoma. The dramatic therapeutic response to pembrolizumab was associated with peripheral blood circulating memory T cells and mature Natural Killer cells after 6 months (24 weeks) of therapy.
#40 Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma | Journal for ImmunoTherapy of Cancer | Full Text
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0357-3
The ongoing response to pembrolizumab supports PD-L1 expression may be the most important biomarker predicting benefit from anti-PD1 therapy in sebaceous carcinoma. […] In conclusion, the ongoing, durable response to checkpoint inhibition described in this report supports clinical testing of anti-PD1 checkpoint inhibitors in MSS and MSI-high sebaceous carcinoma.
#41 Sebaceous Gland Carcinoma Treatment & Management: Surgical Therapy, Follow-up, Complications
https://emedicine.medscape.com/article/1213781-treatment
Treatment aims to remove the malignant lesion to prevent local or systemic spread. The treatment of sebaceous gland carcinoma is adequate surgical excision, with wide surgical margins and fresh frozen section controls to delineate the tumor edges. Lymph node evaluation is necessary to evaluate metastasis. […] If diffuse involvement of the upper and lower eyelids is present, exenteration is required. Obtain a biopsy specimen of the areas of reddening of the conjunctiva that are suggestive of sebaceous gland carcinoma at the time of surgery. […] Local surgical excision of the tumor as initial treatment was performed in 25 patients. Exenteration was the initial surgery performed in 4 patients. […] With wide excision and no evidence of metastasis, surgery results in a cure for the malignancies. However, sebaceous lesions have a high incidence of recurrence and metastasis.
#42 Recent updates on the management of ocular sebaceous gland carcinoma – IJOOO
https://www.ijooo.org/html-article/19462
Mohs micrographic surgery consists of removal and extemporaneous analysis of every skin stratum until the identification of disease-free margins. […] Topical and systemic chemotherapy can be useful in SGC for the reduction of tumor size and prevention of micrometastasis. […] Recently systemic Chemotherapy has been recommended for patients with metastatic or locally advanced periocular SGC. […] Radiation therapy, especially brachytherapy, has been proven as an efficient treatment of ocular SGC. […] Cryotherapy has a certain effect on ocular SGC with pagetoid spread to the conjunctiva or cornea. […] In recent years, targeted therapy is having an emerging role in the treatment of refractory tumors such as advanced melanoma. […] Orbital exenteration is usually reserved for the treatment of extensive SGC or those tumours that have invaded the orbital soft tissue and are relentlessly progressive despite other treatments.
#43 Sebaceous Carcinoma: Symptoms, Photos, Staging, Treatment
https://www.healthline.com/health/skin-cancer/sebaceous-carcinoma
The recommended first-line treatment for sebaceous carcinoma is surgery to remove it. Possible surgical options include excision and Mohs surgery, a type of specialized surgery used to treat some skin cancers. […] Radiation therapy may be a better choice if you cannot have surgery or if the cancer has spread to your lymph nodes. […] If cancer has spread to the conjunctiva (the protective membrane of your eye), a doctor may also recommend mitomycin C cream or cryotherapy. […] In rare cases where cancer has spread significantly into the eye, you may require surgery to remove the eyeball and surrounding tissue. […] Sebaceous carcinoma is more aggressive than other, more common nonmelanoma skin cancers. Still, with early diagnosis and treatment, people with sebaceous carcinoma can improve their chances of a favorable outcome.
#44 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#45 Sebaceous Carcinoma Treatment | U.S. Dermatology Partners
https://www.usdermatologypartners.com/services/skin-cancer/sebaceous-carcinoma-treatment/
Sebaceous carcinoma can develop in any sebaceous glands, which lubricate the skin, but it most often begins on or around the eyelids. […] If sebaceous carcinoma spreads, it can be deadly. […] If you notice a growth on your eyelid, itâs important to make an appointment with your dermatologist. The sooner sebaceous carcinoma is diagnosed and treated, the better the outcome. […] Most sebaceous carcinomas can be treated with surgery. Treatment options may include: Mohs surgery, a highly specialized technique that removes the cancerous tissue while preserving surrounding healthy tissue; Excision or surgical removal of the tumor and some surrounding tissue; Cryotherapy, which freezes the growth with liquid nitrogen; Surgery to remove lymph nodes, if the cancer has spread; Radiation, if the cancer has spread or if surgery is not an option. […] Because sebaceous carcinoma is an aggressive form of cancer, itâs important to treat the condition early and keep all follow-up appointments to check for recurrence. Fortunately, when found and treated early, sebaceous carcinoma has a high survival rate.
#46 Sebaceous Carcinoma – EyeWiki
https://eyewiki.org/Sebaceous_Carcinoma
Sebaceous carcinoma is a rare, highly malignant, and potentially lethal tumor of the skin, which most commonly occurs in the eyelid. […] The mainstay of treatment is surgical excision. It is important to ensure a full thickness specimen, and to consider obtaining map biopsies of the conjunctiva. If invasive, orbital exenteration may be indicated. […] Mohs micrographic surgery or complete circumferential peripheral and deep margin assessment (CCPDMA) are first line treatments for sebaceous carcinoma. […] Topical mitomycin or cryotherapy may improve outcomes where positive conjunctival margins exist, or in the setting of conjunctival recurrence after repeat Mohs or CCPDMA or pagetoid spread. […] Wide local excision may also be considered in some cases. When sebaceous cell carcinoma invades the orbit, exenteration may be considered. […] Sentinel lymph node biopsies can be considered for periocular tumors Stage T2c or higher. […] Sebaceous carcinoma prognosis relies on several factors, including size, location, treatment approach, and tumor stage.
#47 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Regional radiotherapy is also preferred over complete node dissection in patients who have positive sentinel lymph node biopsy results, are status post lymphadenectomy, show evidence of nodal metastasis, or require palliative treatment. Systemic therapies for the management of unresectable sebaceous carcinoma include immunotherapies or targeted therapies such as antiandrogens, retinoid receptor ligands, and epidermal growth factor receptor inhibitors.
#48 Sebaceous gland carcinoma | Skin cancer | Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/skin-cancer/types/sebaceous-gland-carcinoma
You should have treatment at a specialist skin cancer centre because this is a rare type of skin cancer. A team of doctors discuss the best treatment and care for you. They are called a multidisciplinary team (MDT). The MDT includes a skin specialist (dermatologist), a plastic surgeon and a cancer radiotherapy specialist (clinical oncologist). […] The main treatments for sebaceous gland carcinoma are: surgery, radiotherapy. […] Surgery is the main treatment. Your surgeon aims to remove all the cancer cells and some healthy tissue around it (a healthy margin). […] Radiotherapy means the use of radiation, usually x-rays, to kill cancer cells. You might have it: after surgery to kill any cancer cells that might have been left behind – this is called adjuvant treatment, as your only treatment if you cant have surgery for any reason. […] Treatment for cancer that has spread to other parts of the body wont get rid of the cancer. But it can control your symptoms and help you feel better. You might have chemotherapy. Your doctor might offer you treatment as part of a clinical trial.
#49 Sebaceous carcinoma and systemic chemotherapy
https://pmc.ncbi.nlm.nih.gov/articles/PMC3618649/
Sebaceous gland carcinoma is a rare malignant tumor, which arises from the adnexal epithelium of sebaceous glands. […] Role of chemotherapy in the management of metastatic sebaceous carcinoma is evolving. Combination chemotherapy can result in long term remission as described in this case report. […] The mainstay of treatment of SC is surgical excision. For regional and metastatic disease, radiation, and chemotherapeutic drugs have been used with varying degrees of response. […] Our case report is the first in literature, in which patients had complete clinicoradiological response with combination of paclitaxel and carboplatin for lung metastasis. This shows that chemotherapy can be a good option in treatment of sebaceous carcinoma with metastasis as our patient showed complete remission of lung metastasis and was disease free after 6 months of treatment. […] New chemotherapeutic regimens need to be evaluated in treatment of sebaceous carcinoma as our case report has shown combination of carboplatin and paclitaxel as a promising treatment option.
#50 Skin cancer types: Sebaceous carcinoma diagnosis & treatment
https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment
Radiation treatments: Radiation is not the first choice for treating SC. This treatment may be an option for: […] Easing a patients pain if the cancer has spread. […] Treating patients who refuse or cannot withstand surgery. […] Treating patients who have had surgery but may still have some cancer. […] Cryotherapy: This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. For some patients, joining a clinical trial may be the best treatment option.
#51 Sebaceous carcinoma – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/sebaceous-carcinoma/diagnosis-treatment/drc-20577655
Radiation therapy. Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. Radiation therapy can be used after surgery to kill any cancer cells that might remain. Radiation therapy may be used alone if surgery isn’t an option. […] Clinical trials. Clinical trials to test new treatments may be an option. Ask your healthcare professional whether you’re eligible to participate in a clinical trial.
#52 Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma | Journal for ImmunoTherapy of Cancer | Full Text
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0357-3
Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck. […] Optimal treatment of metastatic sebaceous malignancy has not been firmly established. To date, treatment approaches have been adapted from regimens used to treat head and neck cancers, with several retrospective series showing effectiveness of multi-agent cisplatin-based chemotherapy. […] While the sporadic form of SC is not generally associated with mutations in DNA mismatch repair genes, cases associated with Muir-Torre and microsatellite instability (MSI) are likely to respond to immunotherapy. […] Anti-PD1 checkpoint inhibitors are approved for malignant melanoma and merkel cell carcinoma, a polyomavirus associated skin adnexal tumor. […] This is the first report describing objective clinical and radiographic responses following immunotherapy for widely metastatic sebaceous carcinoma. The dramatic therapeutic response to pembrolizumab was associated with peripheral blood circulating memory T cells and mature Natural Killer cells after 6 months (24 weeks) of therapy.
#53 Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma | Journal for ImmunoTherapy of Cancer | Full Text
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0357-3
The ongoing response to pembrolizumab supports PD-L1 expression may be the most important biomarker predicting benefit from anti-PD1 therapy in sebaceous carcinoma. […] In conclusion, the ongoing, durable response to checkpoint inhibition described in this report supports clinical testing of anti-PD1 checkpoint inhibitors in MSS and MSI-high sebaceous carcinoma.
#54 Sebaceous Carcinoma – StatPearls – NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK610689/
Regional radiotherapy is also preferred over complete node dissection in patients who have positive sentinel lymph node biopsy results, are status post lymphadenectomy, show evidence of nodal metastasis, or require palliative treatment. Systemic therapies for the management of unresectable sebaceous carcinoma include immunotherapies or targeted therapies such as antiandrogens, retinoid receptor ligands, and epidermal growth factor receptor inhibitors.
#55 Recent updates on the management of ocular sebaceous gland carcinoma – IJOOO
https://www.ijooo.org/html-article/19462
Mohs micrographic surgery consists of removal and extemporaneous analysis of every skin stratum until the identification of disease-free margins. […] Topical and systemic chemotherapy can be useful in SGC for the reduction of tumor size and prevention of micrometastasis. […] Recently systemic Chemotherapy has been recommended for patients with metastatic or locally advanced periocular SGC. […] Radiation therapy, especially brachytherapy, has been proven as an efficient treatment of ocular SGC. […] Cryotherapy has a certain effect on ocular SGC with pagetoid spread to the conjunctiva or cornea. […] In recent years, targeted therapy is having an emerging role in the treatment of refractory tumors such as advanced melanoma. […] Orbital exenteration is usually reserved for the treatment of extensive SGC or those tumours that have invaded the orbital soft tissue and are relentlessly progressive despite other treatments.
#56 Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma | BMC Ophthalmology | Full Text
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01367-3
Mohs surgery has been recommended as treatment of sebaceous carcinoma with excellent results with 11% recurrence rate for primary tumours. […] Good results have also been published using frozen sections and therefore many authors prefer it. […] Postoperative radiation after exenteration in T3 tumors (AJCC 7-th edition) is reported to significantly reduce the risk of recurrent disease. […] Radiation has also been recommended for recurrent disease after exenteration and postoperatively if insufficient margins or perineural spread is detected. […] Exenteration should be considered if there is extensive growth in the orbit or recurrent orbital disease after globe sparing surgery. […] The follow-up was only 18months, but chemoreduction seems probably a promising treatment method. […] The length of follow-up is debatable. Many studies report 5 years or longer follow-up. […] The reported rates for nodal recurrences are 8-23% and for distant metastasis 2-14%. […] In our study most respondents used a 5-year follow-up, which in the light of published studies seems a justified minimum follow-up time.
#57 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#58 Sebaceous Carcinoma: Symptoms, Photos, Staging, Treatment
https://www.healthline.com/health/skin-cancer/sebaceous-carcinoma
The 5-year relative survival rate for people with localized sebaceous carcinoma is 78%. That drops to about 50% if the disease has spread. […] Since this type of cancer is aggressive and often returns, your doctor will want to monitor you closely after undergoing treatment and require frequent checks for at least 3 years.
#59 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#60 Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma | BMC Ophthalmology | Full Text
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01367-3
Mohs surgery has been recommended as treatment of sebaceous carcinoma with excellent results with 11% recurrence rate for primary tumours. […] Good results have also been published using frozen sections and therefore many authors prefer it. […] Postoperative radiation after exenteration in T3 tumors (AJCC 7-th edition) is reported to significantly reduce the risk of recurrent disease. […] Radiation has also been recommended for recurrent disease after exenteration and postoperatively if insufficient margins or perineural spread is detected. […] Exenteration should be considered if there is extensive growth in the orbit or recurrent orbital disease after globe sparing surgery. […] The follow-up was only 18months, but chemoreduction seems probably a promising treatment method. […] The length of follow-up is debatable. Many studies report 5 years or longer follow-up. […] The reported rates for nodal recurrences are 8-23% and for distant metastasis 2-14%. […] In our study most respondents used a 5-year follow-up, which in the light of published studies seems a justified minimum follow-up time.
#61 Sebaceous Carcinoma: Symptoms, Photos, Staging, Treatment
https://www.healthline.com/health/skin-cancer/sebaceous-carcinoma
The 5-year relative survival rate for people with localized sebaceous carcinoma is 78%. That drops to about 50% if the disease has spread. […] Since this type of cancer is aggressive and often returns, your doctor will want to monitor you closely after undergoing treatment and require frequent checks for at least 3 years.
#62 Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma | BMC Ophthalmology | Full Text
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01367-3
Mohs surgery has been recommended as treatment of sebaceous carcinoma with excellent results with 11% recurrence rate for primary tumours. […] Good results have also been published using frozen sections and therefore many authors prefer it. […] Postoperative radiation after exenteration in T3 tumors (AJCC 7-th edition) is reported to significantly reduce the risk of recurrent disease. […] Radiation has also been recommended for recurrent disease after exenteration and postoperatively if insufficient margins or perineural spread is detected. […] Exenteration should be considered if there is extensive growth in the orbit or recurrent orbital disease after globe sparing surgery. […] The follow-up was only 18months, but chemoreduction seems probably a promising treatment method. […] The length of follow-up is debatable. Many studies report 5 years or longer follow-up. […] The reported rates for nodal recurrences are 8-23% and for distant metastasis 2-14%. […] In our study most respondents used a 5-year follow-up, which in the light of published studies seems a justified minimum follow-up time.
#63 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#64 Sebaceous carcinoma: Foothill Dermatology Medical Center: Dermatology
https://www.foothillderm.com/blog/sebaceous-carcinoma
Sebaceous carcinoma (SC) is a rare skin cancer. It is considered an aggressive skin cancer because it can spread. […] Found early and treated, treatment is often successful. […] The sooner this cancer is diagnosed and treated the better the outcome. If SC spreads, it can be deadly. […] If SC is suspected, you also will need a thorough physical exam, a thorough eye exam, and other medical tests. […] Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC: Excision and Mohs surgery. […] After the cancer surgery, some patients need reconstructive surgery. This surgery is often performed immediately after the cancer surgery. […] Radiation is not the first choice for treating SC. This treatment may be an option for easing a patient’s pain if the cancer has spread, treating patients who refuse or cannot withstand surgery, or treating patients who have had surgery but may still have some cancer.
#65 Sebaceous gland carcinoma | Skin cancer | Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/skin-cancer/types/sebaceous-gland-carcinoma
You should have treatment at a specialist skin cancer centre because this is a rare type of skin cancer. A team of doctors discuss the best treatment and care for you. They are called a multidisciplinary team (MDT). The MDT includes a skin specialist (dermatologist), a plastic surgeon and a cancer radiotherapy specialist (clinical oncologist). […] The main treatments for sebaceous gland carcinoma are: surgery, radiotherapy. […] Surgery is the main treatment. Your surgeon aims to remove all the cancer cells and some healthy tissue around it (a healthy margin). […] Radiotherapy means the use of radiation, usually x-rays, to kill cancer cells. You might have it: after surgery to kill any cancer cells that might have been left behind – this is called adjuvant treatment, as your only treatment if you cant have surgery for any reason. […] Treatment for cancer that has spread to other parts of the body wont get rid of the cancer. But it can control your symptoms and help you feel better. You might have chemotherapy. Your doctor might offer you treatment as part of a clinical trial.
#66
https://link.springer.com/article/10.1007/s11864-017-0490-0
Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. […] Early treatment is important given the potential of sebaceous carcinoma to spread to the regional lymph nodes and beyond. […] Surgery, including Mohs micrographic surgery, remains the primary treatment modality for sebaceous carcinoma. Mohs micrographic surgery has the advantage of complete margin evaluation and low recurrence rates. […] Advanced cases may be treated with orbital exenteration, radiation therapy, chemotherapy, or combination therapy.
#67 Sebaceous carcinoma – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/sebaceous-carcinoma/diagnosis-treatment/drc-20577655
Radiation therapy. Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. Radiation therapy can be used after surgery to kill any cancer cells that might remain. Radiation therapy may be used alone if surgery isn’t an option. […] Clinical trials. Clinical trials to test new treatments may be an option. Ask your healthcare professional whether you’re eligible to participate in a clinical trial.
#68 Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma | Journal for ImmunoTherapy of Cancer | Full Text
https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0357-3
The ongoing response to pembrolizumab supports PD-L1 expression may be the most important biomarker predicting benefit from anti-PD1 therapy in sebaceous carcinoma. […] In conclusion, the ongoing, durable response to checkpoint inhibition described in this report supports clinical testing of anti-PD1 checkpoint inhibitors in MSS and MSI-high sebaceous carcinoma.
#69 Sebaceous Carcinoma: Symptoms, Causes & Treatment
https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma
Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. […] Dermatologists often perform Mohs surgery to treat this cancer. […] Surgical options include: […] Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Radiation therapy may be done if you’re not a candidate for surgery. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. […] Sebaceous carcinoma may be aggressive. For as many as 1 in 4 people, the cancer comes back (recurs) or spreads (metastasizes) after treatment. […] It’s important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.
#70 Sebaceous carcinoma: Foothill Dermatology Medical Center: Dermatology
https://www.foothillderm.com/blog/sebaceous-carcinoma
Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. The purpose of a clinical trial is to study how well a new treatment or a new way of treating a disease works. […] When found early and treated, the prognosis is good. It is important to keep in mind that SC is an aggressive cancer. This cancer can return after treatment. […] Follow-up visits can help find this skin cancer in its earliest stage. The sooner the cancer is found and treated the better the outcome.