Materiały źródłowe

• #1 Sebaceous Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24087-sebaceous-carcinoma

  Sebaceous carcinoma is a rare type of skin cancer that starts in your skins oil-producing (sebaceous) glands. Its an aggressive cancer that can return after treatment. Dermatologists often perform Mohs surgery to treat this cancer. […] Sebaceous carcinoma is an aggressive skin cancer, which means it spreads quickly. […] Surgical options include: Wide local excision to cut out (excise) the tumor along with a margin of normal surrounding tissue. Mohs surgery to remove the cancerous tumor and surrounding healthy tissue (the margin) in stages to ensure all cancer cells are gone. […] Treatments for metastatic sebaceous carcinoma vary, depending on where the cancer spreads. You may have surgery to remove affected lymph nodes. You may also have radiation therapy or other cancer treatments. […] With treatment, more than 90% of those affected survive the disease. The outlook is better for those who receive treatment within six months. […] Its important to receive follow-up care so your healthcare providers can watch for signs of the cancers return and treat it right away.

• #2 Sebaceous carcinoma: evidence-based clinical practice guidelines – PubMed

  https://pubmed.ncbi.nlm.nih.gov/31797796/

  Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. […] In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. […] For diagnosis, we concluded that deep biopsy is often required; furthermore, differential diagnoses that mimic the condition can be excluded with special histological stains. […] For treatment, the recommended first-line therapy is surgical removal, followed by margin assessment of the peripheral and deep tissue edges; conjunctival mapping biopsies can facilitate surgical planning.

• #3 Sebaceous Carcinoma | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancer/skin/what-skin-cancer/sebaceous-carcinoma

  Sebaceous carcinoma is a rare and aggressive type of skin cancer that develops in a sebaceous gland, which produces sebum, a mixture of complex oils that help to lubricate the skin. […] The primary treatment for sebaceous carcinoma is surgery, which may include one of the following procedures: […] After surgery, some patients may need plastic and reconstructive surgery (especially if the cancer was on the eyelid) to restore function and appearance. […] Survival rate is high among patients whose sebaceous carcinoma is detected and treated at an early stage. However, sebaceous carcinoma is considered somewhat aggressive, and it can recur after treatment. For these reasons, it is important that patients follow up with their doctors as scheduled.

• #4 Malignant Tumors of the Eye – Kadrmas Eye Care New England

  http://www.kadrmaseyecare.com/tumor.html

  Sebaceous carcinoma (SC) is an invasive and aggressive tumor that occurs in any of the bodys oil glands. However, 75 percent of cases are located in the oil glands near the eye. SC can often look like a chalazion or even chronic blepharitis. A sebaceous carcinoma is a small, painless, nodule usually located on the upper lid. Often, an SC may be yellow. SC can also cause eyelashes in the affected area to fall out. SC is a form of skin cancer that can metastasize to other parts of the body. Since the symptoms of SC mimic benign conditions, diagnosis can be difficult. If you have had episodes of apparently recurrent chalazia or styes, or blepharitis that hasnt responded to rigorous treatment, you should make your eye doctor aware of these facts, especially if you did not seek treatment for these conditions. […] If you doctor suspects, SC a tissue biopsy will be needed, along with surgical removal of the tumor.

• #5 Aggressive sebaceous carcinoma of the scalp: a case report and literature review – Li – Translational Cancer Research

  https://tcr.amegroups.org/article/view/54815/html

  Sebaceous carcinoma (SC) is an uncommon and potentially aggressive adnexal neoplasm. […] Aggressive SC of the scalp is extremely rare. […] A wide local lesion excision with I stage repair of dura mater and I stage bone graft of skull was performed in our department. […] The patient was treated with external radiation to prevent recurrence and was followed for 3 years with favorable results. […] Early precise diagnosis and improved radical treatment remain essential steps against aggressive cutaneous malignancy. Patients with aggressive SC of the scalp should be closely followed to assess recurrence and distant metastasis. […] The importance of a thorough physical examination cannot be emphasized enough, and early detection is critical to provide patients with the best chance for a favorable outcome.

• #6 Sebaceous Carcinoma | Cancer Care and Oncology | Bon Secours

  https://www.bonsecours.com/health-care-services/cancer-care-oncology/conditions/sebaceous-carcinoma

  Sebaceous carcinoma is a rare type of skin cancer, and it starts in an oil gland in your skin. […] Treatment for sebaceous carcinoma typically involves surgery, chemotherapy and/or radiation therapy. […] Your oncologist may use one or more of the following tests to diagnose this condition: Physical exam – your doctor will perform a complete physical exam, including asking questions about your health history, symptoms and related risk factors. Your doctor will perform a skin exam and eye exam as part of the physical exam. […] Depending on your personal health history, the extent of your sebaceous carcinoma and other factors, your oncologist may recommend one or more of the following treatment options: Surgery – your doctor will likely recommend a surgical procedure to remove the cancerous area, along with a margin of healthy tissue.

• #7 Skin cancer types: Sebaceous carcinoma diagnosis & treatment

  https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment

  If your dermatologist suspects that you have sebaceous carcinoma (SC), your dermatologist needs some essential information. Be sure to tell your dermatologist if you have: […] During the office visit, your dermatologist will: […] Your dermatologist may also perform a skin biopsy. A skin biopsy is the only way to diagnose skin cancer. […] If SC is suspected, you also will need: […] Diagnosing SC can take time. The diagnosis is often based on many factors, including: […] Before creating a treatment plan for SC, your dermatologist or ophthalmologist wants to answer these questions: […] To find out whether the cancer has spread, you may need more medical tests, such as: […] Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC: […] During Mohs surgery, the Mohs surgeon cuts out the tumor plus a very small amount of healthy looking tissue surrounding the tumor.

• #8 Poor differentiation, MTS spark concerns with sebaceous carcinoma

  https://www.dermatologytimes.com/view/poor-differentiation-mts-spark-concerns-sebaceous-carcinoma

  In diagnosing and treating sebaceous carcinoma, poorly differentiated tumors carry a poor prognosis, and the presence of Muir Torre syndrome (MTS) brings additional cancer risk, according to an expert. […] When you diagnose a patient with sebaceous carcinoma, first perform the evaluation for MTS, an autosomal dominant genetic syndrome that stems from a defect in the mismatch repair proteins involved in DNA repair, Dr. Hanlon says. […] To treat sebaceous carcinoma, Dr. Hanlon says, The treatment of choice is surgical – whether it be excision or Mohs micrographic surgery, depending on the tumor location and patients overall health. […] Adjuvant radiation also may play a role in treating sebaceous carcinomas, she says. To monitor for recurrences, Ultimately, close clinical follow-up is important, Dr. Hanlon says.

• #9 Sebaceous Carcinoma | Parkview Cancer Institute

  https://www.parkview.com/medical-services/cancer/cancers-we-treat/sebaceous-carcinoma

  Sebaceous carcinoma is a rare form of skin cancer. […] Successful treatment depends on age, stage and location of cancer, and other factors. […] Your treatment will depend on age, overall health, cancer stage, cancer size and location, and other factors. […] Here at Parkview, youll be cared for by a dedicated team of skin cancer specialists and sub-specialists, not a general oncologist who treats all types of cancer.

• #10 Sebaceous gland carcinoma | Skin cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/skin-cancer/types/sebaceous-gland-carcinoma

  Sebaceous gland carcinoma is a very rare type of skin cancer. […] You should have treatment at a specialist skin cancer centre because this is a rare type of skin cancer. A team of doctors discuss the best treatment and care for you. […] Your doctor will discuss your treatment, its benefits and the possible side effects. […] You have regular appointments with your doctor or nurse after treatment. […] During the follow up appointments, your doctor checks how you are. You can raise any concerns or problems you have with them. […] Coping with a diagnosis of cancer can be difficult. You might feel sad and worry about what will happen. Being well informed about your cancer and its treatment can make it easier to make decisions and cope with what happens afterwards.

• #11 Sebaceous carcinoma | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/sebaceous-carcinoma

  Sebaceous carcinoma treatment often involves surgery to remove the cancer. […] Sebaceous carcinoma treatment often involves surgery to remove the cancer. Other treatments might be options in certain situations. […] Treatment options may include: […] Surgery to remove the cancer. Your healthcare professional may recommend a procedure to remove the cancer and some of the healthy tissue that surrounds it. […] Mohs surgery is a specialized type of surgery that involves removing thin layers of cancer-containing skin until only cancer-free tissue is left. […] Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. […] Clinical trials to test new treatments may be an option. Ask your healthcare professional whether you’re eligible to participate in a clinical trial.

• #12 Skin cancer types: Sebaceous carcinoma diagnosis & treatment

  https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/treatment

  After the cancer surgery, some patients need reconstructive surgery. This surgery is often performed immediately after the cancer surgery. […] When the cancer spreads to the lymph nodes, the patient may have surgery to remove the affected lymph nodes. […] Radiation is not the first choice for treating SC. This treatment may be an option for: […] This treatment involves removing diseased skin by freezing it. More research is needed to find out whether this can be an effective treatment for SC. […] When found early and treated, the prognosis is good. It is important to keep in mind that SC is an aggressive cancer. This cancer can return after treatment. […] When found early and treated, SC has a high survival rate. The best way to find this cancer early is to return for check-ups. Your dermatologist will tell you how often you should return for check-ups. It is essential to keep all appointments.

• #13 Sebaceous Carcinoma of the Eyelid » New York Eye Cancer Center

  https://eyecancer.com/eye-cancer/conditions/eyelid-tumors/sebaceous-carcinoma-eyelid/

  Sebaceous carcinoma arises from the glands within the eyelids, caruncle or eyebrow. They are more commonly found on the upper eyelid and in middle-aged patients. […] Sebaceous carcinomas are one of the rarest eye cancers and can look like a chalazion (stye) or conjunctivitis. In that sebaceous carcinoma can mimic these relatively benign diseases, eye care specialists should be suspicious of this tumor in any patient with persistent conjunctivitis, blepharoconjunctivitis or chronic/recurrent chalazion. Therefore, any conjunctivitis or chalazion that is not getting better after 3 months of observation, should be biopsied. […] Treatment requires a resection of the malignancy. Frozen section control can be used to provide negative margins. Larger surgeries, cryodestruction and radiation may be required if resection is not possible. Exenteration (complete removal of the orbital contents) is sometimes required for extensive or recurrent disease.

• #14 Sebaceous Carcinoma of the Eyelid – University of Miami

  https://scholarship.miami.edu/esploro/outputs/bookChapter/Sebaceous-Carcinoma-of-the-Eyelid/991031598693902976

  Sebaceous carcinoma (SC) is a malignant neoplasm that frequently affects the eyelids. […] The standard of care for SC is surgical excision, however, there is a reoccurrence rate of approximately 4% after excision. […] In these cases, it is necessary to treat patients with further excision and possibly radiation. […] Not all patients can have their tumors treated with surgery. […] In cases where there is diffuse intraepithelial seeding of the tumor cells, metastasis, or orbital invasion, other methods such as chemotherapy, radiation, and exenteration must be performed. […] It is essential that we elucidate the cellular mechanisms regarding the etiology of SC to develop better methods of diagnosis and treatment for the future.

• #15 Sebaceous carcinoma: evidence-based clinical practice guidelines – PubMed

  https://pubmed.ncbi.nlm.nih.gov/31797796/

  Radiotherapy can be considered for cases with nerve or lymph node involvement, and as the primary treatment in patients who are ineligible for surgery. […] Post-treatment clinical examination should occur every 6 months for at least 3 years. […] No specific systemic therapies for advanced disease can be recommended, but targeted therapies and immunotherapies are being developed.

• #16 Sebaceous Carcinoma | Cancer Care and Oncology | Bon Secours

  https://www.bonsecours.com/health-care-services/cancer-care-oncology/conditions/sebaceous-carcinoma

  You may need to undergo chemotherapy after surgery so that your doctor can destroy any cancerous cells that couldn’t be removed surgically or if the cancer has spread beyond the original area. […] You may need to undergo radiation therapy to destroy any cancerous cells that couldn’t be removed surgically or if the cancer has spread beyond the original area. […] If you experience any of these symptoms, start by voicing your concerns and symptoms to your primary care provider.

• #17 Aggressive sebaceous carcinoma of the scalp: a case report and literature review – Li – Translational Cancer Research

  https://tcr.amegroups.org/article/view/54815/html

  Therefore, it is recommended that an enlarged resection be used for the intracranial invasive tumor and then repair of the dura mater or skull in I stage. […] The role of radiation therapy and systemic chemotherapy after surgery is not clear in the extraocular SC, which are only suggested for patients who are poor surgical candidates or those with recurrent or metastatic disease. […] The patient was treated with external radiation to prevent recurrence and was followed for 3 years with favorable results. […] In conclusion, an extremely rare case of aggressive SC on the scalp is reported here. […] Early precise diagnosis and improved radical treatment remain an essential step against aggressive cutaneous malignancy. Patients with aggressive SC of the scalp should be followed up closely to assess recurrence and distant metastasis.

• #18 Skin cancer types: Sebaceous carcinoma self-care

  https://www.aad.org/public/diseases/skin-cancer/types/common/sebaceous/self-care

  If youve been treated for sebaceous carcinoma (SC), dermatologists recommend the following: […] Keep all follow-up appointments with your doctors. SC is an aggressive skin cancer. It can return after treatment. Follow-up visits can help find this skin cancer in its earliest stage. The sooner the cancer is found and treated the better the outcome. […] Perform skin self-exams as often as your dermatologist recommends. If you have received treatment for SC, it is essential that you learn how to perform a skin self-exam. Your dermatologist or someone in your dermatologists office can teach you exactly what you need to know, including how to examine your eyelids and certain lymph nodes. […] Protect your skin from the sun. If you have had SC, sun protection can be helpful. The suns rays can weaken our immune system. Sun exposure also increases your risk of developing other types of skin cancer. […] Ask your doctors what else you can do to improve your outcome. A patients needs can be unique. Be sure to ask your doctors what could help you.

• #19

  https://journals.lww.com/ojji/fulltext/2023/07020/nasal_sebaceous_carcinoma__a_case_treated_at_a.4.aspx

  Sebaceous carcinoma of nasal location is an extremely rare site of presentation as well as a rare cutaneous malignancy. […] Careful clinical history, histopathological examination, and radiologic findings are all important for the correct diagnosis of sebaceous carcinoma of the nasal cavity. […] Since there is no standard treatment available for this tumor, one needs to be aware about the treatment options available. […] The treatment-related morbidities are significant for the disease owing to its site of origin being head-and-neck region, which requires complex facial surgeries and radiation. […] The present case undergo surgical resection with negative surgical margins followed by receiving adjuvant radiotherapy and doing well without any disease relapse at 24 months of follow-up. […] Sebaceous carcinoma should be treated aggressively to obtain free margin, and adjuvant radiotherapy may be required as per the indications. […] After treatment completion, the patients should be closely followed up due to their high recurrence rate and high tendency to metastasize.

• #20 Sebaceous carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/sebaceous-carcinoma

  What are my treatment options? […] What are the potential risks of these treatment options? […] Do any of the treatments cure my cancer? […] Your healthcare professional is likely to ask you several questions, such as: […] How bad are your symptoms? […] What, if anything, seems to improve your symptoms? […] What, if anything, appears to worsen your symptoms?

• #21 Sebaceous carcinoma | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/sebaceous-carcinoma

  Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you. […] If your health professional thinks that you might have sebaceous carcinoma, that person may refer you to a specialist. […] For sebaceous carcinoma, some basic questions to ask your doctor include: […] What are my treatment options? […] What are the potential risks of these treatment options? […] Do any of the treatments cure my cancer?

• #22 Sebaceous carcinoma | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/sebaceous-carcinoma?content_id=CON-20306946

  Sebaceous carcinoma treatment often involves surgery to remove the cancer. […] Treatment options may include: […] Surgery to remove the cancer. Your healthcare professional may recommend a procedure to remove the cancer and some of the healthy tissue that surrounds it. […] Mohs surgery is a specialized type of surgery that involves removing thin layers of cancer-containing skin until only cancer-free tissue is left. […] Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. […] Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you. […] If your health professional thinks that you might have sebaceous carcinoma, that person may refer you to a specialist. […] For sebaceous carcinoma, some basic questions to ask your doctor include: […] What are my treatment options? […] What are the potential risks of these treatment options? […] Do any of the treatments cure my cancer? […] What would happen if I chose not to have treatment?

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