Materiały źródłowe

• #1 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] Though mammograms are important for the early detection of breast cancer, they are less likely to detect ILC than other types of breast cancer. Because ILC grows in straight lines rather than in a mass or lump, it doesn’t always appear clearly on a mammogram. Therefore, a breast MRI may be needed to diagnose ILC. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently. ILC tends to invade breast tissue by spreading out in straight lines rather than amassing to form a solid clump or lump. Because ILC does not usually form into a solid lump, it is harder to detect through breast self-exams and mammograms. Therefore, other types of diagnostic tests and imaging in addition to a mammogram may be needed to diagnose ILC.

• #2 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #3 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. […] Unlike ductal carcinomas, ILCs usually do not form a lump. Instead, the cancer cells grow in straight lines. […] When ILC spreads, or metastasizes, it often moves into gastrointestinal tract, ovaries, peritoneum, retroperitoneum and leptomeninges (part of the membrane that surrounds and protects the brain and spinal cord). […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. They are called hormone-receptor positive breast cancers. […] Mammograms and ultrasounds also arent effective in detecting the cancer because of its cell growth pattern. The best screening approach is a breast MRI, which isnt standard of care.

• #4 Invasive Lobular Breast Cancer – Susan G. Komen®

  https://www.komen.org/breast-cancer/diagnosis/invasive-lobular-breast-cancer/

  Invasive lobular cancer or infiltrating lobular carcinoma (ILC) is invasive breast cancer that begins in the lobules of the breast. The lobules are small, round sacs in the breast that produce milk for breastfeeding. […] With ILC, the cancer cells in the lobules invade nearby breast tissue and may travel from the breast to other parts of the body. […] Invasive lobular cancer (ILC) is the second most common type of invasive breast cancer (invasive ductal cancer (IDC) is the most common). About 10% to 15% of invasive breast cancers are ILC. […] Compared to IDC, ILC tends to have a larger tumor size, but a lower tumor grade at diagnosis. […] Under a microscope, invasive lobular cancer (ILC) cells most often appear in a single file order. Because ILC tumors grow in this way, there may not be a mass (lump) present. This can make ILC harder to find on a mammogram than some other breast cancers.

• #5 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] Though mammograms are important for the early detection of breast cancer, they are less likely to detect ILC than other types of breast cancer. Because ILC grows in straight lines rather than in a mass or lump, it doesn’t always appear clearly on a mammogram. Therefore, a breast MRI may be needed to diagnose ILC. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently. ILC tends to invade breast tissue by spreading out in straight lines rather than amassing to form a solid clump or lump. Because ILC does not usually form into a solid lump, it is harder to detect through breast self-exams and mammograms. Therefore, other types of diagnostic tests and imaging in addition to a mammogram may be needed to diagnose ILC.

• #6 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  Invasive Lobular Carcinoma Diagnosis […] Your doctor will start with a physical exam of your breasts and nearby lymph nodes. If they feel any problems such as thickening, hardening, or swelling, you may have tests including: […] Mammogram. ILC can be hard to spot on a mammogram, which makes X-ray pictures of your breast, because the cancer cells tend to grow in a line rather than in a mass. […] Ultrasound. It uses sound waves to create images of the inside of your breast. An ultrasound may be better at finding ILC than a mammogram. […] Biopsy. If they find a suspicious area, your doctor will order a biopsy to check the cells. Most biopsies use a needle to take out a sample of cells from the breast. In some cases, the doctor will remove a larger sample or the entire tumor. […] CT scan. This is a powerful X-ray that makes detailed pictures inside your body.

• #7 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. In addition, these breast cancers are also more likely to be multi-focal (occurring in more than one location) or bilateral (occurring in both breasts), which complicates accurate screening, detection, and treatment. […] Current research shows that MRI may be better able to detect lobular carcinoma than mammography, and new techniques are being developed, with several in clinical trials now. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment.

• #8 Invasive Lobular Carcinoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/ilc.html

  Invasive lobular carcinoma (ILC), also known as lobular breast cancer, accounts for 15% of all new breast cancer diagnoses. ILC is the second most common histological type of breast cancer, with approximately 47,500 lobular breast cancer diagnoses each year in the United States. […] In 2025, it is estimated that there are 316,950 new cases of female breast cancer in the United States. Among these newly diagnosed breast cancer cases, 10%-15% are diagnosed as invasive lobular carcinoma. […] The hallmark of lobular breast cancer is the lack of the protein E-cadherin, which helps cancer cells adhere to each other. Because E-cadherin is absent in ILC, ILC tumor cells typically grow diffusely in unconnected lines, throughout the breast without distorting the surrounding structures or forming a lump. This makes them extremely hard to detect on mammograms and ultrasound, especially in women with dense breast tissue, or to visualize elsewhere in the body if metastasized.

• #9 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  The classic form of ILC is the most common subtype and may coexist with LN in up to 90 % of cases. […] The histology of ILC is similar to that of LN; specifically, the cells are small, discohesive and uniform, with a small cytoplasm, cytoplasmic Magenta Bodies and a low mitotic index. […] Although it was initially questioned, the current grading of ILC is performed according to the Nottingham classification, which demonstrates a correlation between grading, survival and disease-free intervals. […] The absence or discrete expression of E-cadherin is the major IHC marker of the differentiation between ILC and invasive ductal carcinoma. […] MRI shows great sensitivity for ILC, ranging from 83 to 100 %. […] Despite the evidence of the high sensitivity of MRI for the detection of ILC, its role in preoperative staging is still controversial. […] Current evidence has shown changes in the clinical management of patients who had a preoperative breast MRI and the clear benefit of a minor rate of surgical re-assessment in patients who underwent conservative surgeries.

• #10 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and -catenin staining) features. […] ILC usually has a luminal A molecular phenotype and is often estrogen receptor (ER)- and progesterone receptor (PR)-positive and HER2 neu-negative, therefore being a prime candidate for hormonal therapy. It also shows a poor response to neoadjuvant therapy compared to invasive breast carcinoma of NST. […] ILC presents specific molecular characteristics compared to other subtypes of invasive breast carcinoma. […] This study aims to increase awareness of these rare variants of ILC. […] The differential diagnosis of ILC with extracellular mucin production includes invasive mucinous carcinoma of Capella type B, solid papillary carcinoma (SPC), mixed ILC and mucinous carcinoma, metaplastic matrix-producing carcinoma (MMPC), and polymorphous mammary adenocarcinoma.

• #11 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is diagnosed using a range of tests, which may include: A mammogram, An ultrasound scan, A core biopsy of the breast and sometimes lymph nodes, A fine needle aspiration (FNA) of the breast and sometimes lymph nodes, A breast MRI scan. […] You may be diagnosed with invasive lobular breast cancer during routine breast screening before you have noticed any symptoms. However, lobular breast cancer can be more difficult to see on a mammogram than other types of breast cancer.

• #12 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is the second most common type of breast cancer. It is also known as invasive lobular carcinoma. […] Your GP may refer you to a breast clinic if you have any symptoms that could be due to invasive lobular breast cancer. You may also be referred to a breast clinic for tests if your screening mammogram shows an abnormal area. […] At the breast clinic the doctor or specialist nurse takes your medical history and examines your breasts. They also feel for any swollen (enlarged) lymph nodes under your arms and at the base of your neck. […] You usually have a number of tests to check for breast cancer including: a mammogram, an ultrasound, a biopsy, a breast MRI scan. […] There are many breast cancer trials. So your doctor might ask if you would like to take part in a clinical trial. […] Breast cancer research is looking at screening and diagnosis.

• #13 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #14 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  Invasive Lobular Carcinoma Diagnosis […] Your doctor will start with a physical exam of your breasts and nearby lymph nodes. If they feel any problems such as thickening, hardening, or swelling, you may have tests including: […] Mammogram. ILC can be hard to spot on a mammogram, which makes X-ray pictures of your breast, because the cancer cells tend to grow in a line rather than in a mass. […] Ultrasound. It uses sound waves to create images of the inside of your breast. An ultrasound may be better at finding ILC than a mammogram. […] Biopsy. If they find a suspicious area, your doctor will order a biopsy to check the cells. Most biopsies use a needle to take out a sample of cells from the breast. In some cases, the doctor will remove a larger sample or the entire tumor. […] CT scan. This is a powerful X-ray that makes detailed pictures inside your body.

• #15 Lobular Carcinoma

  https://www.upmc.com/locations/hospitals/magee/services/magee-womens-cancers/breast-cancer-program/types-of-breast-cancer/lobular-carcinoma

  Invasive lobular carcinoma is characterized when the mutated cells spread from the lobules into the breast tissue. […] In lobular carcinoma, lumps are uncommon and may be difficult to detect by breast exam or mammogram. You may notice thickening or fullness in the breast instead. […] Experts at the Magee-Womens Breast Cancer Program use a variety of tests and procedures to diagnose and screen for breast cancer, including: […] A noninvasive test using high-frequency sound waves to produce real-time pictures of tumors. […] An imaging technique using a computer, a magnetic field, and radio waves to produce images of the body’s soft tissues. […] An imaging procedure of the breast using low-energy x-rays to screen for or detect breast cancer and other abnormalities. […] The use of a needle to extract a tissue sample from the breast to test for cancer cells. […] If you’re diagnosed with lobular carcinoma, treatment will depend on your general health and the results of your tests. […] Your doctors and other specialists at the Magee-Womens Breast Cancer Program will work with you to consider your options and determine a course of action.

• #16 Chemotherapy Benefits in Invasive Lobular Carcinoma

  https://www.rockymountaincancercenters.com/referring-providers-blog/chemotherapy-benefits-in-invasive-lobular-carcinoma

  Diagnosis of ILC can be particularly challenging because its hard to see on imaging tests. […] In addition, ILC hasn’t been studied as much as invasive ductal cancer, said Dr. Solipuram, and in the early stages of invasive lobular carcinoma, there may not be any noticeable signs since this type of breast cancer is less likely to cause a firm or distinct breast lump. […] Diagnosis of ILC is difficult due to distinctive biological hallmarks, including loss of cell adhesion molecule E-cadherin, which leads to cells with a discohesive morphology and proliferation into single-file strands. […] As a result of the biological hallmarks, diagnosis by physical exam of ILC is challenging since patients often present with limited clinical signs and do not always have a breast lump. […] While mammography is considered the gold standard for diagnosing breast cancer, ILC is challenging to detect due to the infiltrative tumor growth pattern.

• #17 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Diagnosing invasive lobular carcinoma and other kinds of breast cancer often begins with an exam and a discussion of your symptoms. Imaging tests can look at the breast tissue for anything that’s not typical. To confirm whether there is cancer or not, a sample of tissue is removed from the breast for testing. […] A mammogram is an X-ray of the breast tissue. Mammograms are commonly used to screen for breast cancer. If a screening mammogram finds something concerning, you might have another mammogram to look at the area more closely. This more-detailed mammogram is called a diagnostic mammogram. It’s often used to look closely at both breasts. Invasive lobular carcinoma is less likely to be detected on a mammogram than other types of breast cancer are. Still, a mammogram is a useful diagnostic test.

• #18 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  Invasive lobular carcinoma (ILC) and lobular neoplasia (LN) are two distinct conditions that still pose challenges regarding to their classification, diagnosis and management. […] ILC is the second most common breast malignancy and has typical histological features, such as infiltrative growth and low desmoplasia. […] Ultrasonography (US) may detect almost 75 % of the ILCs missed by mammography and represents the modality of choice for guiding biopsies. Magnetic resonance imaging (MRI) exhibits a high sensitivity for the diagnosis of ILC and for detecting synchronous lesions. […] ILC represents approximately 515 % of all breast carcinomas and exhibits challenging characteristics, such as low sensitivity in screening examinations, tumour size underestimation in both mammograms and clinical examinations, and a high prevalence of synchronous lesions.

• #19 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. […] However, advances in mammography, ultrasound, and magnetic resonance imaging present opportunities to improve the diagnosis and preoperative assessment of ILC. […] The low density of tumor cells and lack of desmoplastic stromal reaction in ILC account for the difficulty in its detection on physical examination, mammography, and even gross pathologic evaluation. […] Mammograms have been found to have a low sensitivity (57 to 79 %) in detecting ILC, with up to 30 % of cases not visualized at all on mammography, and 35 % of lesions only visible on one view. […] The sensitivity of mammography in detecting ILC is lower, ranging between 57 and 81 %.

• #20 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  Invasive Lobular Carcinoma Diagnosis […] Your doctor will start with a physical exam of your breasts and nearby lymph nodes. If they feel any problems such as thickening, hardening, or swelling, you may have tests including: […] Mammogram. ILC can be hard to spot on a mammogram, which makes X-ray pictures of your breast, because the cancer cells tend to grow in a line rather than in a mass. […] Ultrasound. It uses sound waves to create images of the inside of your breast. An ultrasound may be better at finding ILC than a mammogram. […] Biopsy. If they find a suspicious area, your doctor will order a biopsy to check the cells. Most biopsies use a needle to take out a sample of cells from the breast. In some cases, the doctor will remove a larger sample or the entire tumor. […] CT scan. This is a powerful X-ray that makes detailed pictures inside your body.

• #21 Invasive lobular carcinoma – Wikipedia

  https://en.wikipedia.org/wiki/Invasive_lobular_carcinoma

  Invasive lobular carcinoma (ILC) is breast cancer arising from the lobules of the mammary glands. It accounts for 510% of invasive breast cancer. Rare cases of this carcinoma have been diagnosed in men (see male breast cancer). […] On mammography, ILC shows spiculated mass with ill-defined margins that has similar or lower density than surrounding breast tissues. This happens only at 4465% of the time. Architectural distortion on surrounding breast tissues is only seen in 1034% of the cases. It can be reported as benign in 816% of the mammography cases. […] Ultrasound has 6898% sensitivity of detecting ILC. ILC shows irregular or angular mass with hypoechoic or heterogenous internal echoes, ill-defined or spiculated margins, and posterior acoustic shadowing. […] Loss of E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.

• #22 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  Invasive lobular cancer (ILC) is the second most common type of breast cancer. It is characterized by a unique growth pattern making it difficult to detect on conventional breast imaging. ILC can be multicentric, multifocal, and bilateral, with a high likelihood of incomplete excision after breast-conserving surgery. […] Our review of the literature finds that MRI and CEM clearly surpass conventional breast imaging in terms of sensitivity, specificity, ipsilateral and contralateral cancer detection, concordance, and estimation of tumor size for ILC. Both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup. […] ILC has been historically difficult to detect on conventional breast imaging as it is often isodense or isoechoic to adjacent normal breast parenchyma and does not present as a palpable mass, also making it difficult to discern on clinical examination. Incomplete excision of ILC is common after breast conservation surgery, ranging from 12% to 60%, leading to re-excisions or even mastectomy.

• #23 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] Though mammograms are important for the early detection of breast cancer, they are less likely to detect ILC than other types of breast cancer. Because ILC grows in straight lines rather than in a mass or lump, it doesn’t always appear clearly on a mammogram. Therefore, a breast MRI may be needed to diagnose ILC. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently. ILC tends to invade breast tissue by spreading out in straight lines rather than amassing to form a solid clump or lump. Because ILC does not usually form into a solid lump, it is harder to detect through breast self-exams and mammograms. Therefore, other types of diagnostic tests and imaging in addition to a mammogram may be needed to diagnose ILC.

• #24 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Diagnosing invasive lobular carcinoma and other kinds of breast cancer often begins with an exam and a discussion of your symptoms. Imaging tests can look at the breast tissue for anything that’s not typical. To confirm whether there is cancer or not, a sample of tissue is removed from the breast for testing. […] A mammogram is an X-ray of the breast tissue. Mammograms are commonly used to screen for breast cancer. If a screening mammogram finds something concerning, you might have another mammogram to look at the area more closely. This more-detailed mammogram is called a diagnostic mammogram. It’s often used to look closely at both breasts. Invasive lobular carcinoma is less likely to be detected on a mammogram than other types of breast cancer are. Still, a mammogram is a useful diagnostic test.

• #25 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The most common mammographic manifestations of ILC include spiculated, ill-defined masses and poorly defined asymmetric densities. […] The overall sensitivity of US for the detection of ILC is reported to be between 68 and 98 %. […] Butler investigated whether US could be helpful specifically in those ILC tumors that are occult on mammography. […] Indeed, 73 % of mammographically invisible ILC tumors were identified by directed US examination. […] Breast MRI has an overall sensitivity of 93 % for detecting ILC, similar to the detection of breast cancers overall (90 %). […] The most common MRI presentation of ILC is that of a mass with irregular or spiculated margins, followed by a non-mass lesion in 20 to 40 % of cases. […] MRI has demonstrated value in specific circumstances, such as screening for women with a 20 % lifetime predisposition for developing breast cancer.

• #26 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  The mammographic presentations of invasive lobular carcinoma include: A mass (up to 65% of cases) with irregular margins mostly speculated but sometimes circumscribed. […] MRI is useful in estimating the extent of invasive lobular carcinoma since it determines tumor margins, size, and multifocality more accurately than ultrasound and mammography. […] The treatment of invasive lobular carcinomas has been a topic of debate due to the potential bilaterality and multifocality that characterize these tumors. […] The multidisciplinary approach to the treatment includes surgery, hormonal therapy, radiation therapy, and chemotherapy. […] Adjuvant hormone therapy is also indicated, given the high percentage of cases that are positive for ER and PR. […] The factors like age, lymph nodes status, tumor size, Ki-67 biomarker, hormonal status can be associated with both recurrence and survival, and histology alone cannot be considered the only predictor.

• #27 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Diagnosing invasive lobular carcinoma and other kinds of breast cancer often begins with an exam and a discussion of your symptoms. Imaging tests can look at the breast tissue for anything that’s not typical. To confirm whether there is cancer or not, a sample of tissue is removed from the breast for testing. […] A mammogram is an X-ray of the breast tissue. Mammograms are commonly used to screen for breast cancer. If a screening mammogram finds something concerning, you might have another mammogram to look at the area more closely. This more-detailed mammogram is called a diagnostic mammogram. It’s often used to look closely at both breasts. Invasive lobular carcinoma is less likely to be detected on a mammogram than other types of breast cancer are. Still, a mammogram is a useful diagnostic test.

• #28 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis.

• #29 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The most common mammographic manifestations of ILC include spiculated, ill-defined masses and poorly defined asymmetric densities. […] The overall sensitivity of US for the detection of ILC is reported to be between 68 and 98 %. […] Butler investigated whether US could be helpful specifically in those ILC tumors that are occult on mammography. […] Indeed, 73 % of mammographically invisible ILC tumors were identified by directed US examination. […] Breast MRI has an overall sensitivity of 93 % for detecting ILC, similar to the detection of breast cancers overall (90 %). […] The most common MRI presentation of ILC is that of a mass with irregular or spiculated margins, followed by a non-mass lesion in 20 to 40 % of cases. […] MRI has demonstrated value in specific circumstances, such as screening for women with a 20 % lifetime predisposition for developing breast cancer.

• #30 Chemotherapy Benefits in Invasive Lobular Carcinoma

  https://www.rockymountaincancercenters.com/referring-providers-blog/chemotherapy-benefits-in-invasive-lobular-carcinoma

  ILC is difficult to detect on a mammogram because ILC cells grow linearly compared to the clumps or masses other breast cancer cells form, Dr. Solipuram said. […] The sensitivity in detecting ILC with a mammogram is between 57% and 81%, with 8% to 24% false-positive rates. […] Using ultrasound in conjunction with a mammogram and physical exam yields a much better detection rate of ILC with a sensitivity of 68% to 98%. […] Due to the nature of ILC, MRI is used in the screening of high-risk breast cancers and comparing mammogram and ultrasound findings. […] MRI has a sensitivity of 93% in detecting ILC. […] Although the use of MRI provides additional diagnostic information that can be missed in standard imaging, this tool should be used in conjunction with other imaging tools to assess patients with ILC accurately.

• #31 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis.

• #32 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  The classic form of ILC is the most common subtype and may coexist with LN in up to 90 % of cases. […] The histology of ILC is similar to that of LN; specifically, the cells are small, discohesive and uniform, with a small cytoplasm, cytoplasmic Magenta Bodies and a low mitotic index. […] Although it was initially questioned, the current grading of ILC is performed according to the Nottingham classification, which demonstrates a correlation between grading, survival and disease-free intervals. […] The absence or discrete expression of E-cadherin is the major IHC marker of the differentiation between ILC and invasive ductal carcinoma. […] MRI shows great sensitivity for ILC, ranging from 83 to 100 %. […] Despite the evidence of the high sensitivity of MRI for the detection of ILC, its role in preoperative staging is still controversial. […] Current evidence has shown changes in the clinical management of patients who had a preoperative breast MRI and the clear benefit of a minor rate of surgical re-assessment in patients who underwent conservative surgeries.

• #33 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  The sensitivity rates for MRI range from 83% to 100%, with most studies reporting a sensitivity rate greater than 95%. […] The literature consistently reports MRI as the imaging modality with the strongest correlation of imaging to pathology tumor size estimate for ILC. […] One of the main benefits of including MRI as part of the diagnostic workup for patients newly diagnosed with ILC is the detection of additional ipsilateral and/or contralateral breast cancer. […] The prediction of nodal status is particularly important for patients with ILC after neoadjuvant therapy (NAC or NAE) as the upgrading or downgrading of axillary lymph nodes influences axillary surgery decisions. […] Our review of the literature finds that MRI and CEM clearly surpass US, DM, and DBT in terms of sensitivity, specificity, ipsilateral and contralateral detection, concordance, and estimation of tumor size and extent of disease within the breast for ILC. Importantly, both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup.

• #34 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  The sensitivity rates for MRI range from 83% to 100%, with most studies reporting a sensitivity rate greater than 95%. […] The literature consistently reports MRI as the imaging modality with the strongest correlation of imaging to pathology tumor size estimate for ILC. […] One of the main benefits of including MRI as part of the diagnostic workup for patients newly diagnosed with ILC is the detection of additional ipsilateral and/or contralateral breast cancer. […] The prediction of nodal status is particularly important for patients with ILC after neoadjuvant therapy (NAC or NAE) as the upgrading or downgrading of axillary lymph nodes influences axillary surgery decisions. […] Our review of the literature finds that MRI and CEM clearly surpass US, DM, and DBT in terms of sensitivity, specificity, ipsilateral and contralateral detection, concordance, and estimation of tumor size and extent of disease within the breast for ILC. Importantly, both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup.

• #35 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  Studies have repeatedly shown that MRI is superior to conventional imaging, not only in terms of its increased sensitivity for detecting ILC, but also for the detection of ipsilateral and contralateral disease. […] Despite an increase in the detection of additional ipsilateral and contralateral disease, and in some cases an ultimate change in surgical management, there is no evidence to support an overall reduction in recurrence or disease-free survival with the use of preoperative MRI. […] The current evidence suggests that there could be advantages of MRI compared with conventional imaging for ILC.

• #36 Pathology Outlines – Invasive lobular carcinoma classic

  https://www.pathologyoutlines.com/topic/breastmalignantlobularclassic.html

  Invasive breast carcinoma with loss of cellular adhesion, characteristically arranged in discohesive or single file patterns […] Mainly histological or radiological […] Diagnosis […] Hypoechoic mass with spiculated or ill defined margins and posterior acoustic shadowing […] Does not consistently present as a mass (44% – 65%) […] Can aid in identifying multifocal or residual disease […] Preoperative breast MRI may improve surgical planning

• #37 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The most common mammographic manifestations of ILC include spiculated, ill-defined masses and poorly defined asymmetric densities. […] The overall sensitivity of US for the detection of ILC is reported to be between 68 and 98 %. […] Butler investigated whether US could be helpful specifically in those ILC tumors that are occult on mammography. […] Indeed, 73 % of mammographically invisible ILC tumors were identified by directed US examination. […] Breast MRI has an overall sensitivity of 93 % for detecting ILC, similar to the detection of breast cancers overall (90 %). […] The most common MRI presentation of ILC is that of a mass with irregular or spiculated margins, followed by a non-mass lesion in 20 to 40 % of cases. […] MRI has demonstrated value in specific circumstances, such as screening for women with a 20 % lifetime predisposition for developing breast cancer.

• #38 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  A breast MRI (magnetic resonance imaging) uses magnetic waves and radio energy to provide a detailed image of the inside of the breast. Because of the level of detail an MRI provides, it is the most common and best way that invasive lobular carcinoma is detected and diagnosed. […] After imaging scans, a breast biopsy will be performed on any suspicious or abnormal areas found in the breast. A biopsy uses a needle to extract tissue or fluid from the suspicious area. It is then studied under a microscope to check for the presence of cancerous cells. […] After invasive lobular carcinoma is confirmed through imaging tests and a biopsy, lab tests will be performed to collect more information about the cancer. The results of the lab tests will be compiled into a pathology report, which may include information such as size and stage of the invasive lobular carcinoma, grade of the invasive lobular carcinoma, lymph node involvement, hormone receptor status, HER2 status, and rate of cell growth.

• #39 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. In addition, these breast cancers are also more likely to be multi-focal (occurring in more than one location) or bilateral (occurring in both breasts), which complicates accurate screening, detection, and treatment. […] Current research shows that MRI may be better able to detect lobular carcinoma than mammography, and new techniques are being developed, with several in clinical trials now. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment.

• #40 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  The sensitivity rates for MRI range from 83% to 100%, with most studies reporting a sensitivity rate greater than 95%. […] The literature consistently reports MRI as the imaging modality with the strongest correlation of imaging to pathology tumor size estimate for ILC. […] One of the main benefits of including MRI as part of the diagnostic workup for patients newly diagnosed with ILC is the detection of additional ipsilateral and/or contralateral breast cancer. […] The prediction of nodal status is particularly important for patients with ILC after neoadjuvant therapy (NAC or NAE) as the upgrading or downgrading of axillary lymph nodes influences axillary surgery decisions. […] Our review of the literature finds that MRI and CEM clearly surpass US, DM, and DBT in terms of sensitivity, specificity, ipsilateral and contralateral detection, concordance, and estimation of tumor size and extent of disease within the breast for ILC. Importantly, both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup.

• #41 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Historically, two breast cancer subtypes known as invasive lobular carcinoma and ductal carcinoma have been grouped together. […] A recently published comprehensive review and new research being presented at the 2022 American Society of Clinical Oncology Annual Meeting (ASCO) by breast medical oncologist Jason Mouabbi, M.D., is helping to distinguish invasive lobular carcinoma as its own subtype and define more tailored treatment approaches. […] Invasive lobular carcinoma, also called lobular breast cancer, forms in the cells of the breast that produce milk. […] Mammograms and ultrasounds also arent effective in detecting the cancer because of its cell growth pattern. The best screening approach is a breast MRI, which isnt standard of care. […] Until MRI becomes more widely used, Im afraid that lobular cancer is going to be underdetected, Mouabbi says.

• #42 Invasive lobular carcinoma of the breast | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/invasive-lobular-carcinoma-of-the-breast?lang=us

  Invasive lobular carcinoma is characterized microscopically by malignant monomorphic cells that form loosely dispersed linear columns that invade the normal tissues and encircle ducts. […] The sensitivity of mammography for the detection of Invasive lobular carcinoma reportedly ranges between 57-81%. […] Due to its propensity for multicentricity, breast MRI is usually recommended in many countries when histology of a lesion reveals invasive lobular carcinoma. […] Invasive lobular carcinoma shows mild 18F-FDG PET uptake and thus is not very helpful in primary evaluation and assessing treatment response. […] Despite the difficulties of mammographic diagnosis and the propensity for multiplicity and bilaterality, the overall survival rate for patients with invasive lobular carcinoma of a given size and stage is believed to be slightly higher than for patients with invasive ductal carcinomas.

• #43 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  PET scan. Along with a CT scan, this test can help find cancer in lymph nodes and other areas. […] MRI. This uses strong magnets and radio waves to make pictures of the breast and tissues and organs inside your body. […] Bone scan. A radioactive material called a tracer is injected into your arm. It shows up on pictures to tell your doctor whether cancer may have traveled to your bones. […] The results of your exams will tell your doctor if you have cancer and whether its spread so they can recommend the best treatment options. […] […] Invasive lobular carcinoma is breast cancer that begins in the cells of the mammary glands that make milk, called lobules, and spreads to other parts of the breast. It’s the second most common type of breast cancer in the US that often grows slowly, but can be hard to detect. Many different types of treatment exist for ILC and can depend on your stage at diagnosis and the type of treatment you prefer.

• #44 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  PET scan. Along with a CT scan, this test can help find cancer in lymph nodes and other areas. […] MRI. This uses strong magnets and radio waves to make pictures of the breast and tissues and organs inside your body. […] Bone scan. A radioactive material called a tracer is injected into your arm. It shows up on pictures to tell your doctor whether cancer may have traveled to your bones. […] The results of your exams will tell your doctor if you have cancer and whether its spread so they can recommend the best treatment options. […] […] Invasive lobular carcinoma is breast cancer that begins in the cells of the mammary glands that make milk, called lobules, and spreads to other parts of the breast. It’s the second most common type of breast cancer in the US that often grows slowly, but can be hard to detect. Many different types of treatment exist for ILC and can depend on your stage at diagnosis and the type of treatment you prefer.

• #45

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  MRI is the most sensitive imaging modality for detecting ILC, with an overall sensitivity of approximately 93%. […] Emerging imaging modalities, such as contrast-enhanced mammography (CEM) and artificial intelligence (AI)-assisted imaging, are being explored to improve ILC detection further. […] As imaging technology advances, emerging modalities such as CEM, AB-MRI and AI-assisted detection hold promise for improving ILC detection and ensuring earlier diagnosis and better patient outcomes.

• #46

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  The sensitivity of mammography further declines in women with dense breast tissue, where ILC can remain masked by overlapping fibroglandular structures. […] To address these limitations, digital breast tomosynthesis (DBT) or 3D mammography, has been introduced as an adjunct to standard digital mammography (DM). […] DBT improves the conspicuity of ILC by reducing tissue overlap and enhancing the detection of architectural distortions. […] Despite these advances, a proportion of ILCs remains undetected, necessitating supplemental screening methods. […] Ultrasound (US) serves as a valuable supplemental imaging tool, particularly for women with dense breasts or those at increased risk of breast cancer. […] Studies have demonstrated that screening US detects additional ILCs after negative mammography or DBT findings.

• #47 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis.

• #48 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  A breast MRI (magnetic resonance imaging) uses magnetic waves and radio energy to provide a detailed image of the inside of the breast. Because of the level of detail an MRI provides, it is the most common and best way that invasive lobular carcinoma is detected and diagnosed. […] After imaging scans, a breast biopsy will be performed on any suspicious or abnormal areas found in the breast. A biopsy uses a needle to extract tissue or fluid from the suspicious area. It is then studied under a microscope to check for the presence of cancerous cells. […] After invasive lobular carcinoma is confirmed through imaging tests and a biopsy, lab tests will be performed to collect more information about the cancer. The results of the lab tests will be compiled into a pathology report, which may include information such as size and stage of the invasive lobular carcinoma, grade of the invasive lobular carcinoma, lymph node involvement, hormone receptor status, HER2 status, and rate of cell growth.

• #49 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  Ultrasound uses sound waves to make pictures of structures inside the body. A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] A biopsy is a procedure to remove a sample of tissue for testing in a lab. To get the sample, a healthcare professional often puts a needle through the skin and into the breast tissue. The health professional guides the needle using images created with X-rays, ultrasound or another type of imaging. Once the needle reaches the right place, the health professional uses the needle to draw out tissue from the breast. Often, a marker is placed in the spot where the tissue sample was removed. The small metal marker will show up on imaging tests. The marker helps your healthcare team monitor the area of concern.

• #50 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is diagnosed using a range of tests, which may include: A mammogram, An ultrasound scan, A core biopsy of the breast and sometimes lymph nodes, A fine needle aspiration (FNA) of the breast and sometimes lymph nodes, A breast MRI scan. […] You may be diagnosed with invasive lobular breast cancer during routine breast screening before you have noticed any symptoms. However, lobular breast cancer can be more difficult to see on a mammogram than other types of breast cancer.

• #51 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/breast-cancer/invasive-lobular-carcinoma-(lc)-

  Invasive lobular carcinoma affects the milk-producing glands (lobules) in the breast and can spread (metastasize) to other parts of the body. A mixed carcinoma can have features of both invasive ductal carcinoma (IDC) and invasive lobular breast cancer. […] Sometimes called infiltrating lobular carcinoma, this is the second most common type of breast cancer after IDC, accounting for about 10 of all invasive breast cancers. […] Mammograms are the fastest, most accurate way of detecting an abnormal growth in your breast. With tomosynthesis, or 3D mammography, radiology technologists can get breast images from multiple angles, enhancing the accuracy of a reading and reducing the potential need for repeat scans. […] Your doctor may request a noninvasive imaging exam, such as breast ultrasound or breast MRI, if you have dense breasts and you’re at a higher risk of breast cancer especially for those with a 20 percent or higher lifetime risk for breast cancer.

• #52 Invasive Lobular Carcinoma (ILC): Symptoms, Diagnosis and Treatme

  https://www.longdom.org/open-access/invasive-lobular-carcinoma-ilc-symptoms-diagnosis-and-treatment-59587.html

  Invasive lobular carcinoma causes and risk factors include: […] Diagnosis of invasive lobular carcinoma includes […] Mammogram-On a mammogram ILC can be hard to spot, which makes X-ray pictures of your breast, because the cancer cells tend to grow in a line rather than in a mass. […] Ultrasound-Images of the inside of your breast are created by sound waves. Than a mammogram, an ultrasound may be better at finding ILC. […] Biopsy-Doctor will order a biopsy to check the cells if any suspicious area is found. Needle is used for most biopsies to take out a sample of cells from the breast. In some cases, a larger sample or the entire tumor will removed. […] CT scan-The detailed pictures inside the body are shown by this powerful X-ray. […] PET scan-Cancer in lymph nodes and other areas can be found when this test done along with a CT scan. […] MRI-To make pictures of the breast and things inside the body, this MRI uses strong magnets and radio waves. […] Bone scan-Into the arm a radioactive material called a tracer is injected. It shows up on pictures to tell whether cancer may have travelled to your bones.

• #53 Invasive Lobular Breast Cancer (ILC) | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/i/invasive-lobular-breast-cancer-ilc.html

  Invasive lobular breast cancer (ILC), also known as infiltrating lobular carcinoma, is the second most common form of invasive breast cancer. It makes up 10 to 15 percent of breast cancer cases. […] ILC may be diagnosed during a mammogram. However, due to the nature of ILC tumors, they are often difficult to see on a mammogram. Other imaging tools such as magnetic resonance imaging (MRI) or ultrasound may be used to study the area of concern. […] If the medical team sees evidence of ILC, a biopsy will be performed. During a biopsy, a sample of the abnormal tissue will be taken using a needle. The doctor may use stereotactic images, such as mammography or ultrasound, to guide the needle to the area of concern. A specialist, known as a pathologist, will examine the tissue sample under a microscope and determine if cancer is present.

• #54 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  Ultrasound uses sound waves to make pictures of structures inside the body. A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] A biopsy is a procedure to remove a sample of tissue for testing in a lab. To get the sample, a healthcare professional often puts a needle through the skin and into the breast tissue. The health professional guides the needle using images created with X-rays, ultrasound or another type of imaging. Once the needle reaches the right place, the health professional uses the needle to draw out tissue from the breast. Often, a marker is placed in the spot where the tissue sample was removed. The small metal marker will show up on imaging tests. The marker helps your healthcare team monitor the area of concern.

• #55 Invasive Lobular Breast Cancer Program | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/breast-oncology/programs/invasive-lobular-breast-cancer

  Invasive lobular breast cancer does not often form a lump and therefore can be hard to detect through a breast exam and can even be difficult to see in a mammogram. For this reason, if your doctor thinks you might have invasive lobular breast cancer, they may recommend additional breast imaging tests. […] Tests and procedures to diagnose invasive lobular breast cancer include: […] Mammogram: X-ray images of the breast. At our center, we use digital mammograms, which provide a clear, two-dimensional image highlighting unusual structures such as calcifications or masses, which may need further evaluation. […] Ultrasound: Imaging that can capture the size and structure of a potential tumor. In conjunction with mammography, it is a highly useful tool for diagnosis. […] Biopsy: Procedure to remove a sample of breast tissue for testing. Tissue samples collected during a biopsy procedure are examined by pathologists who specialize exclusively in breast cancer. Pathologists’ findings are critical to determining the best treatment for your cancer, and they are key members of your medical team, providing consultation to clinicians and, at times, working side by side with surgeons. Our pathologists not only evaluate tissues in order to characterize your cancer, but they also investigate any unusual or unexpected findings, using microscopes and analysis to observe and test tissue. Pathologists in our program see hundreds of invasive lobular breast cancer biopsies per year and are very skilled at identifying this less-common form of breast cancer.

• #56 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and -catenin staining) features. […] ILC usually has a luminal A molecular phenotype and is often estrogen receptor (ER)- and progesterone receptor (PR)-positive and HER2 neu-negative, therefore being a prime candidate for hormonal therapy. It also shows a poor response to neoadjuvant therapy compared to invasive breast carcinoma of NST. […] ILC presents specific molecular characteristics compared to other subtypes of invasive breast carcinoma. […] This study aims to increase awareness of these rare variants of ILC. […] The differential diagnosis of ILC with extracellular mucin production includes invasive mucinous carcinoma of Capella type B, solid papillary carcinoma (SPC), mixed ILC and mucinous carcinoma, metaplastic matrix-producing carcinoma (MMPC), and polymorphous mammary adenocarcinoma.

• #57 Overdiagnosis of lobular carcinoma of breast- A review of histomorphological features and immunohistochemistry: A case series – IJPO

  https://www.ijpo.co.in/html-article/18453

  Invasive lobular carcinoma (ILC) accounts for 5%15% of all invasive breast cancers (BCs) and is the second most common type of BC behind invasive ductal carcinoma (IDC) of no special type. ILC of the breast is characterized morphologically by small, noncohesive cells that infiltrate the stroma in a single-file pattern(Indian file pattern). ILC tumours display features associated with a good prognosis, being low grade, oestrogen receptor positive and is mainly associated with the complete loss of E-cadherin (E-cad) expression. […] Our study found that there was a histomorphological pitfall in the diagnosis of IDC. In ambiguous cases with histologically equivocal features, a strong, complete, membranous E-cadherin expression may help in resolving the problem and in aiding in the subclassification of invasive breast carcinoma. […] A negative E-cadherin stain acts as a sensitive and specific biomarker to confirm the diagnosis of invasive lobular carcinoma.

• #58 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  The classic form of ILC is the most common subtype and may coexist with LN in up to 90 % of cases. […] The histology of ILC is similar to that of LN; specifically, the cells are small, discohesive and uniform, with a small cytoplasm, cytoplasmic Magenta Bodies and a low mitotic index. […] Although it was initially questioned, the current grading of ILC is performed according to the Nottingham classification, which demonstrates a correlation between grading, survival and disease-free intervals. […] The absence or discrete expression of E-cadherin is the major IHC marker of the differentiation between ILC and invasive ductal carcinoma. […] MRI shows great sensitivity for ILC, ranging from 83 to 100 %. […] Despite the evidence of the high sensitivity of MRI for the detection of ILC, its role in preoperative staging is still controversial. […] Current evidence has shown changes in the clinical management of patients who had a preoperative breast MRI and the clear benefit of a minor rate of surgical re-assessment in patients who underwent conservative surgeries.

• #59 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  The classic form of ILC is the most common subtype and may coexist with LN in up to 90 % of cases. […] The histology of ILC is similar to that of LN; specifically, the cells are small, discohesive and uniform, with a small cytoplasm, cytoplasmic Magenta Bodies and a low mitotic index. […] Although it was initially questioned, the current grading of ILC is performed according to the Nottingham classification, which demonstrates a correlation between grading, survival and disease-free intervals. […] The absence or discrete expression of E-cadherin is the major IHC marker of the differentiation between ILC and invasive ductal carcinoma. […] MRI shows great sensitivity for ILC, ranging from 83 to 100 %. […] Despite the evidence of the high sensitivity of MRI for the detection of ILC, its role in preoperative staging is still controversial. […] Current evidence has shown changes in the clinical management of patients who had a preoperative breast MRI and the clear benefit of a minor rate of surgical re-assessment in patients who underwent conservative surgeries.

• #60 Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods | Insights into Imaging | Full Text

  https://insightsimaging.springeropen.com/articles/10.1007/s13244-014-0324-6

  The classic form of ILC is the most common subtype and may coexist with LN in up to 90 % of cases. […] The histology of ILC is similar to that of LN; specifically, the cells are small, discohesive and uniform, with a small cytoplasm, cytoplasmic Magenta Bodies and a low mitotic index. […] Although it was initially questioned, the current grading of ILC is performed according to the Nottingham classification, which demonstrates a correlation between grading, survival and disease-free intervals. […] The absence or discrete expression of E-cadherin is the major IHC marker of the differentiation between ILC and invasive ductal carcinoma. […] MRI shows great sensitivity for ILC, ranging from 83 to 100 %. […] Despite the evidence of the high sensitivity of MRI for the detection of ILC, its role in preoperative staging is still controversial. […] Current evidence has shown changes in the clinical management of patients who had a preoperative breast MRI and the clear benefit of a minor rate of surgical re-assessment in patients who underwent conservative surgeries.

• #61 Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer | Modern Pathology

  https://www.nature.com/articles/s41379-022-01135-2

  ILC is primarily a histopathological diagnosis based on standard hematoxylin and eosin staining (HE). […] According to the WHO-classification of breast tumors (5th edition), immunohistochemistry (IHC) is not required for the diagnosis of ILC, as a proportion of these tumors express E-cadherin despite the typical morphology of ILC. […] However, many pathologists rely on E-cadherin IHC in routine practice to classify cases as ILC. […] Moreover, recent central pathology reviews of randomized clinical trials have demonstrated relative overdiagnosis of ILC in local pathological laboratories, as only ~60% of the locally diagnosed ILCs were confirmed by central pathology review. […] When IHC is used, antibodies recognizing E-cadherin are preferred because loss of E-cadherin supports the diagnosis of ILC, acting as a surrogate marker for the underlying genomic alteration.

• #62 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  The differential diagnosis of ILC with papillary features includes solid papillary carcinoma (SPC), encapsulated papillary carcinoma (EPC), the solid or alveolar variant of ILC, an ILC-SPC collision tumor, confluent growth of LCIS, and colonization of a papillary neoplasm by lobular carcinoma in situ. […] Tubular carcinoma, the tubulolobular variant of ILC, and mixed-type invasive breast carcinoma of NST and ILC may be considered in the differential diagnosis of ILC with tubular elements. […] The presence of tubular or pseudocribriform structures does not exclude a diagnosis of ILC, but an E-cadherin stain should be performed whenever these are present. […] The result of misdiagnosis in these cases can be the misclassification of an ILC as a mucinous carcinoma with a favorable prognosis. In contrast, ILC clinical behavior is more aggressive than mucinous carcinoma, characterized as initially indolent but slowly progressive. […] Careful examination of lesions with the abovementioned characteristics on small biopsy specimens may reveal morphological findings suggestive of ILC (presence of signet-ring cells, lack of cellular cohesion, limited areas with a single-file pattern) that may otherwise be missed.

• #63 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  A breast MRI (magnetic resonance imaging) uses magnetic waves and radio energy to provide a detailed image of the inside of the breast. Because of the level of detail an MRI provides, it is the most common and best way that invasive lobular carcinoma is detected and diagnosed. […] After imaging scans, a breast biopsy will be performed on any suspicious or abnormal areas found in the breast. A biopsy uses a needle to extract tissue or fluid from the suspicious area. It is then studied under a microscope to check for the presence of cancerous cells. […] After invasive lobular carcinoma is confirmed through imaging tests and a biopsy, lab tests will be performed to collect more information about the cancer. The results of the lab tests will be compiled into a pathology report, which may include information such as size and stage of the invasive lobular carcinoma, grade of the invasive lobular carcinoma, lymph node involvement, hormone receptor status, HER2 status, and rate of cell growth.

• #64 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and -catenin staining) features. […] ILC usually has a luminal A molecular phenotype and is often estrogen receptor (ER)- and progesterone receptor (PR)-positive and HER2 neu-negative, therefore being a prime candidate for hormonal therapy. It also shows a poor response to neoadjuvant therapy compared to invasive breast carcinoma of NST. […] ILC presents specific molecular characteristics compared to other subtypes of invasive breast carcinoma. […] This study aims to increase awareness of these rare variants of ILC. […] The differential diagnosis of ILC with extracellular mucin production includes invasive mucinous carcinoma of Capella type B, solid papillary carcinoma (SPC), mixed ILC and mucinous carcinoma, metaplastic matrix-producing carcinoma (MMPC), and polymorphous mammary adenocarcinoma.

• #65 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. […] Unlike ductal carcinomas, ILCs usually do not form a lump. Instead, the cancer cells grow in straight lines. […] When ILC spreads, or metastasizes, it often moves into gastrointestinal tract, ovaries, peritoneum, retroperitoneum and leptomeninges (part of the membrane that surrounds and protects the brain and spinal cord). […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. They are called hormone-receptor positive breast cancers. […] Mammograms and ultrasounds also arent effective in detecting the cancer because of its cell growth pattern. The best screening approach is a breast MRI, which isnt standard of care.

• #66 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because detection is challenging and patients dont see changes in their breast, 60% to 70% of patients diagnoses are changed to a higher stage after surgery. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] Most ILCs have high levels of the receptor for the female hormone estrogen. Patients with these cancers receive hormone therapy, which blocks the interaction of estrogen with the cancer cells estrogen receptors or lowers the bodys natural estrogen production. […] An accurate diagnosis is the first step in successful treatment for ILC. […] Imaging exams are used to look for cancer inside the body. […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. […] Patients with suspected ILC will also be tested for the loss of E-cadherin. The absence of this molecule is a defining feature of the disease.

• #67 Invasive Lobular Breast Cancer – Susan G. Komen®

  https://www.komen.org/breast-cancer/diagnosis/invasive-lobular-breast-cancer/

  Treatment for invasive lobular cancer (ILC) is planned in the same way as treatment is planned for all breast cancers. Treatment isn’t based on whether the cancer is ILC, invasive ductal cancer or other tumor type. […] ILC tends to be hormone receptor-positive and HER2-negative. […] Most cases of invasive lobular cancer (ILC) are hormone receptor-positive and HER2-negative. Some findings show chemotherapy (in addition to hormone therapy) may not benefit all people with hormone receptor-positive, HER2-negative ILC. […] Oncotype DX is a test of tumor tissue that can help determine the benefit of adding chemotherapy to treatment for some hormone receptor-positive, HER2-negative early breast cancers. It can help identify some people with hormone receptor-positive, HER2-negative ILC who may get a survival benefit from chemotherapy (in addition to hormone therapy).

• #68 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because detection is challenging and patients dont see changes in their breast, 60% to 70% of patients diagnoses are changed to a higher stage after surgery. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] Most ILCs have high levels of the receptor for the female hormone estrogen. Patients with these cancers receive hormone therapy, which blocks the interaction of estrogen with the cancer cells estrogen receptors or lowers the bodys natural estrogen production. […] An accurate diagnosis is the first step in successful treatment for ILC. […] Imaging exams are used to look for cancer inside the body. […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. […] Patients with suspected ILC will also be tested for the loss of E-cadherin. The absence of this molecule is a defining feature of the disease.

• #69 Overdiagnosis of lobular carcinoma of breast- A review of histomorphological features and immunohistochemistry: A case series – IJPO

  https://www.ijpo.co.in/html-article/18453

  Invasive lobular carcinoma (ILC) accounts for 5%15% of all invasive breast cancers (BCs) and is the second most common type of BC behind invasive ductal carcinoma (IDC) of no special type. ILC of the breast is characterized morphologically by small, noncohesive cells that infiltrate the stroma in a single-file pattern(Indian file pattern). ILC tumours display features associated with a good prognosis, being low grade, oestrogen receptor positive and is mainly associated with the complete loss of E-cadherin (E-cad) expression. […] Our study found that there was a histomorphological pitfall in the diagnosis of IDC. In ambiguous cases with histologically equivocal features, a strong, complete, membranous E-cadherin expression may help in resolving the problem and in aiding in the subclassification of invasive breast carcinoma. […] A negative E-cadherin stain acts as a sensitive and specific biomarker to confirm the diagnosis of invasive lobular carcinoma.

• #70 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  The mammographic presentations of invasive lobular carcinoma include: A mass (up to 65% of cases) with irregular margins mostly speculated but sometimes circumscribed. […] MRI is useful in estimating the extent of invasive lobular carcinoma since it determines tumor margins, size, and multifocality more accurately than ultrasound and mammography. […] The treatment of invasive lobular carcinomas has been a topic of debate due to the potential bilaterality and multifocality that characterize these tumors. […] The multidisciplinary approach to the treatment includes surgery, hormonal therapy, radiation therapy, and chemotherapy. […] Adjuvant hormone therapy is also indicated, given the high percentage of cases that are positive for ER and PR. […] The factors like age, lymph nodes status, tumor size, Ki-67 biomarker, hormonal status can be associated with both recurrence and survival, and histology alone cannot be considered the only predictor.

• #71 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/breast-cancer/invasive-lobular-carcinoma-(lc)-

  More than 80 percent of breast cancer growths arise in milk ducts. If your symptoms include a watery, blood-tinged discharge from the nipple, your surgeon will use ductoscopy to find the lesion to sample or remove it. It uses a fiber-optic scope less than a millimeter thick inserted into the milk duct at the nipple to send images to a computer monitor. […] A biopsy is a small sample of the suspicious breast tissue that’s removed and tested. Biopsies can be performed in several ways, depending on the circumstances: fine-needle aspiration (minimally invasive biopsy), image-guided core needle biopsy, cyst aspiration, ductoscopy (milk ducts) and surgical biopsy (excisional or incisional biopsy). […] This test looks for estrogen and progesterone (hormone) receptors in your cancer tissue. If your breast cancer cells have estrogen and progesterone receptors, the cancer may grow more quickly. The test tells your doctor whether treatment to block estrogen and progesterone will be effective.

• #72 Invasive Lobular Breast Cancer – Susan G. Komen®

  https://www.komen.org/breast-cancer/diagnosis/invasive-lobular-breast-cancer/

  Treatment for invasive lobular cancer (ILC) is planned in the same way as treatment is planned for all breast cancers. Treatment isn’t based on whether the cancer is ILC, invasive ductal cancer or other tumor type. […] ILC tends to be hormone receptor-positive and HER2-negative. […] Most cases of invasive lobular cancer (ILC) are hormone receptor-positive and HER2-negative. Some findings show chemotherapy (in addition to hormone therapy) may not benefit all people with hormone receptor-positive, HER2-negative ILC. […] Oncotype DX is a test of tumor tissue that can help determine the benefit of adding chemotherapy to treatment for some hormone receptor-positive, HER2-negative early breast cancers. It can help identify some people with hormone receptor-positive, HER2-negative ILC who may get a survival benefit from chemotherapy (in addition to hormone therapy).

• #73 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/breast-cancer/invasive-lobular-carcinoma-(lc)-

  This test measures how many HER2/neu breast cancer genes there are and how much HER2/neu protein is made in a sample of breast tissue. If there are more HER2/neu genes or higher levels of HER2/neu protein than normal, the cancer may grow or spread more quickly. […] Because no tumor has a single mutation, genomic profiling allows the pathologist (cellular expert) to identify groups of mutations in your tumor tissue sample. We then can create a tumor profile for you. That profile helps us determine what type of treatment would be the most effective and how long you should have treatment. […] Surgery can be used as a primary treatment or, it may be combined with other cancer therapies, depending on the diagnosis. Sylvester’s surgical oncologists are highly specialized in surgical options for breast cancer.

• #74 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #75 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis.

• #76 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Staging of invasive lobular carcinoma of the breast is established clinically by imaging studies and physical examination before treatment and is determined pathologically based on histopathological examination of the primary tumor and regional lymph nodes after surgery. […] Several studies have shown that invasive lobular carcinoma has the same, better, or worse prognosis than invasive ductal carcinoma. […] The survival rate of invasive lobular carcinoma of the breast is usually higher than that of invasive ductal carcinoma of the breast.

• #77 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  The stages of invasive lobular carcinoma are the same as the stages for other types of breast cancer. Breast cancer stages range from 0 to 4. A lower number means the cancer is less advanced and more likely to be cured. Stage 0 breast cancer is cancer that is contained within a breast duct. It hasn’t broken out to invade the breast tissue yet. As the cancer grows into the breast tissue and gets more advanced, the stages get higher. A stage 4 breast cancer means that the cancer has spread to other parts of the body.

• #78 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The stages of invasive lobular carcinoma are the same as the stages for other types of breast cancer. Breast cancer stages range from 0 to 4. A lower number means the cancer is less advanced and more likely to be cured. Stage 0 breast cancer is cancer that is contained within a breast duct. It hasn’t broken out to invade the breast tissue yet. As the cancer grows into the breast tissue and gets more advanced, the stages get higher. A stage 4 breast cancer means that the cancer has spread to other parts of the body.

• #79 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  The stages of invasive lobular carcinoma are the same as the stages for other types of breast cancer. Breast cancer stages range from 0 to 4. A lower number means the cancer is less advanced and more likely to be cured. Stage 0 breast cancer is cancer that is contained within a breast duct. It hasn’t broken out to invade the breast tissue yet. As the cancer grows into the breast tissue and gets more advanced, the stages get higher. A stage 4 breast cancer means that the cancer has spread to other parts of the body.

• #80 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #81 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #82 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #83 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. ILC can spread to many different areas of your body. Treatment may include surgery, along with chemotherapy and other anti-cancer drugs. […] About 10% to 15% of breast cancers are invasive lobular breast cancer. Early diagnosis and treatment may cure it. But ILC can spread to other areas of your body many years after your diagnosis and treatment. […] A healthcare provider will ask about your symptoms. Theyll examine your breasts and the area near your armpits. They may do the following tests: Mammogram to look for abnormal masses or changes in your breasts, Breast MRI to get very detailed images of your breast tissue, Breast ultrasound to focus on specific areas of your breasts. […] Your cancer care team will use test results to stage the cancer and plan your treatment. There are four stages of invasive lobular carcinoma: Stage I is a tumor that measures up to 2 centimeters (cm) (about 3/4-inch) across and may be in nearby lymph nodes. Stage II means the tumor is 2 cm and is spreading to nearby lymph nodes. Stage III means theres cancer in your breast and lymph nodes. Stage IV is cancer that has spread to distant areas of your body, such as your lungs, liver or bones.

• #84 What is Invasive Lobular Carcinoma | Breast Cancer Trials

  https://www.breastcancertrials.org.au/what-is-invasive-lobular-carcinoma/?srsltid=AfmBOooNwkYzzqlUKZ3kS8a2i5PtnqDzPrPNoI_TuSbPqd1AtIs-au6K

  If cancer is confirmed, the doctor may examine nearby lymph nodes to see if the cancer has spread. This is an important step in determining the extent or stage of the cancer. […] Understanding the stage of cancer is crucial for planning the most appropriate treatment. Staging considers the size of the tumour, whether it has spread to the lymph nodes, and whether it has spread to other parts of the body. […] ILC are typically oestrogen receptor positive breast cancers, which makes them sensitive to the endocrine (or hormone blocking) treatments such as tamoxifen. […] Depending on the stage of ILC, treatment may include a combination of surgery, radiation therapy, chemotherapy, endocrine (hormone) therapy, and targeted therapies. Treatment for ILC also may include breast surgery, radiation therapy and chemotherapy. In most cases, ILC is usually more responsive to endocrine therapy than chemotherapy and is generally preferred.

• #85 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis. […] Tests and procedures used to stage invasive lobular carcinoma may include: Blood tests, such as a complete blood count and tests to show how well the kidneys and liver are working. Bone scan. CT scan. MRI. Positron emission tomography scan, also called a PET scan.

• #86 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis. […] Tests and procedures used to stage invasive lobular carcinoma may include: Blood tests, such as a complete blood count and tests to show how well the kidneys and liver are working. Bone scan. CT scan. MRI. Positron emission tomography scan, also called a PET scan.

• #87 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  PET scan. Along with a CT scan, this test can help find cancer in lymph nodes and other areas. […] MRI. This uses strong magnets and radio waves to make pictures of the breast and tissues and organs inside your body. […] Bone scan. A radioactive material called a tracer is injected into your arm. It shows up on pictures to tell your doctor whether cancer may have traveled to your bones. […] The results of your exams will tell your doctor if you have cancer and whether its spread so they can recommend the best treatment options. […] […] Invasive lobular carcinoma is breast cancer that begins in the cells of the mammary glands that make milk, called lobules, and spreads to other parts of the breast. It’s the second most common type of breast cancer in the US that often grows slowly, but can be hard to detect. Many different types of treatment exist for ILC and can depend on your stage at diagnosis and the type of treatment you prefer.

• #88 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis. […] Tests and procedures used to stage invasive lobular carcinoma may include: Blood tests, such as a complete blood count and tests to show how well the kidneys and liver are working. Bone scan. CT scan. MRI. Positron emission tomography scan, also called a PET scan.

• #89 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis. […] Tests and procedures used to stage invasive lobular carcinoma may include: Blood tests, such as a complete blood count and tests to show how well the kidneys and liver are working. Bone scan. CT scan. MRI. Positron emission tomography scan, also called a PET scan.

• #90 Invasive lobular carcinoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/invasive-lobular-carcinoma

  The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis. […] Tests and procedures used to stage invasive lobular carcinoma may include: Blood tests, such as a complete blood count and tests to show how well the kidneys and liver are working. Bone scan. CT scan. MRI. Positron emission tomography scan, also called a PET scan.

• #91 What is Invasive Lobular Carcinoma | Breast Cancer Trials

  https://www.breastcancertrials.org.au/what-is-invasive-lobular-carcinoma/?srsltid=AfmBOooNwkYzzqlUKZ3kS8a2i5PtnqDzPrPNoI_TuSbPqd1AtIs-au6K

  If cancer is confirmed, the doctor may examine nearby lymph nodes to see if the cancer has spread. This is an important step in determining the extent or stage of the cancer. […] Understanding the stage of cancer is crucial for planning the most appropriate treatment. Staging considers the size of the tumour, whether it has spread to the lymph nodes, and whether it has spread to other parts of the body. […] ILC are typically oestrogen receptor positive breast cancers, which makes them sensitive to the endocrine (or hormone blocking) treatments such as tamoxifen. […] Depending on the stage of ILC, treatment may include a combination of surgery, radiation therapy, chemotherapy, endocrine (hormone) therapy, and targeted therapies. Treatment for ILC also may include breast surgery, radiation therapy and chemotherapy. In most cases, ILC is usually more responsive to endocrine therapy than chemotherapy and is generally preferred.

• #92 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] Though mammograms are important for the early detection of breast cancer, they are less likely to detect ILC than other types of breast cancer. Because ILC grows in straight lines rather than in a mass or lump, it doesn’t always appear clearly on a mammogram. Therefore, a breast MRI may be needed to diagnose ILC. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently. ILC tends to invade breast tissue by spreading out in straight lines rather than amassing to form a solid clump or lump. Because ILC does not usually form into a solid lump, it is harder to detect through breast self-exams and mammograms. Therefore, other types of diagnostic tests and imaging in addition to a mammogram may be needed to diagnose ILC.

• #93 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. […] Invasive lobular carcinoma is usually associated with lobular carcinoma in situ. […] It is now recognized as a biologically distinct disease from the more common invasive ductal carcinoma, with unique molecular pathogenesis and consequential implications on diagnosis and treatment. An understanding of these differences is crucial to tailor management strategies. […] The challenge with invasive lobular carcinomas is that they can be difficult to detect clinically and radiographically, and consequently tend to be larger at the time of diagnosis. […] It is often difficult to diagnose invasive lobular carcinoma by mammography with higher false-negative rates than for other invasive cancers.

• #94 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. […] However, advances in mammography, ultrasound, and magnetic resonance imaging present opportunities to improve the diagnosis and preoperative assessment of ILC. […] The low density of tumor cells and lack of desmoplastic stromal reaction in ILC account for the difficulty in its detection on physical examination, mammography, and even gross pathologic evaluation. […] Mammograms have been found to have a low sensitivity (57 to 79 %) in detecting ILC, with up to 30 % of cases not visualized at all on mammography, and 35 % of lesions only visible on one view. […] The sensitivity of mammography in detecting ILC is lower, ranging between 57 and 81 %.

• #95 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  A breast ultrasound may give your healthcare team more information about a breast lump. For example, an ultrasound might show whether the lump is a solid mass or a fluid-filled cyst. The healthcare team uses this information to decide what tests you might need next. Invasive lobular carcinoma may be more difficult to detect with ultrasound than other types of breast cancer. […] The tissue sample from a biopsy goes to a lab for testing. Tests can show whether the cells in the sample are cancerous. Other tests give information about the type of cancer and how quickly it’s growing. The results of these tests tell your healthcare team if you have invasive lobular carcinoma. […] Once your healthcare team diagnoses your invasive lobular carcinoma, you may have other tests to figure out the extent of the cancer. This is called the cancer’s stage. Your healthcare team uses your cancer’s stage to understand your prognosis.

• #96 Dr Mukhtar on Challenges in the Diagnosis and Management of Invasive Lobular Carcinoma

  https://www.onclive.com/view/dr-mukhtar-on-challenges-in-the-diagnosis-and-management-of-invasive-lobular-carcinoma

  Rita Mukhtar, MD, discusses challenges in the diagnosis and management of invasive lobular carcinoma. […] Research over the past 15 years has helped identify more histological differences between invasive lobular carcinoma and invasive ductal carcinoma, she adds. […] One notable difference is the growth pattern of invasive lobular carcinoma, which tends to be more diffuse, she says, adding that this complicates detection via imaging modalities such as mammograms, often resulting in later-stage diagnoses for patients with invasive lobular carcinoma. […] Consequently, invasive lobular carcinoma tumors are generally larger at the time of detection and may have a higher likelihood of lymph node involvement, Muktar says. […] Additionally, the difficulty in accurately visualizing invasive lobular carcinoma tumors through imaging also poses significant implications for surgical treatment, Mukhtar explains.

• #97 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. In addition, these breast cancers are also more likely to be multi-focal (occurring in more than one location) or bilateral (occurring in both breasts), which complicates accurate screening, detection, and treatment. […] Current research shows that MRI may be better able to detect lobular carcinoma than mammography, and new techniques are being developed, with several in clinical trials now. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment.

• #98 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. […] Unlike ductal carcinomas, ILCs usually do not form a lump. Instead, the cancer cells grow in straight lines. […] When ILC spreads, or metastasizes, it often moves into gastrointestinal tract, ovaries, peritoneum, retroperitoneum and leptomeninges (part of the membrane that surrounds and protects the brain and spinal cord). […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. They are called hormone-receptor positive breast cancers. […] Mammograms and ultrasounds also arent effective in detecting the cancer because of its cell growth pattern. The best screening approach is a breast MRI, which isnt standard of care.

• #99 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  Invasive lobular cancer (ILC) is the second most common type of breast cancer. It is characterized by a unique growth pattern making it difficult to detect on conventional breast imaging. ILC can be multicentric, multifocal, and bilateral, with a high likelihood of incomplete excision after breast-conserving surgery. […] Our review of the literature finds that MRI and CEM clearly surpass conventional breast imaging in terms of sensitivity, specificity, ipsilateral and contralateral cancer detection, concordance, and estimation of tumor size for ILC. Both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup. […] ILC has been historically difficult to detect on conventional breast imaging as it is often isodense or isoechoic to adjacent normal breast parenchyma and does not present as a palpable mass, also making it difficult to discern on clinical examination. Incomplete excision of ILC is common after breast conservation surgery, ranging from 12% to 60%, leading to re-excisions or even mastectomy.

• #100 Invasive Lobular Carcinoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/ilc.html

  Because the tumors are harder to image and feel, lobular breast cancer is often only diagnosed once tumors are larger than 2cm and later stage, and sometimes already metastatic. […] Many scientific studies have confirmed that lobular breast cancer is a distinct breast cancer type and that it behaves differently from the more common non-lobular breast cancers. […] Though ILC is hardly a rare cancer, at 15% of breast cancers, for decades, in part because of the smaller numbers of patients at any one site and the insufficient standardization of the diagnosis for pathologists and radiologists, there has been very little research. The standard of care for early-stage hormone receptor positive ILC is the same as treatment of hormone receptor positive non-lobular tumors. More research is needed to identify ILC-specific treatment protocols.

• #101 Dr Mukhtar on Challenges in the Diagnosis and Management of Invasive Lobular Carcinoma

  https://www.onclive.com/view/dr-mukhtar-on-challenges-in-the-diagnosis-and-management-of-invasive-lobular-carcinoma

  Rita Mukhtar, MD, discusses challenges in the diagnosis and management of invasive lobular carcinoma. […] Research over the past 15 years has helped identify more histological differences between invasive lobular carcinoma and invasive ductal carcinoma, she adds. […] One notable difference is the growth pattern of invasive lobular carcinoma, which tends to be more diffuse, she says, adding that this complicates detection via imaging modalities such as mammograms, often resulting in later-stage diagnoses for patients with invasive lobular carcinoma. […] Consequently, invasive lobular carcinoma tumors are generally larger at the time of detection and may have a higher likelihood of lymph node involvement, Muktar says. […] Additionally, the difficulty in accurately visualizing invasive lobular carcinoma tumors through imaging also poses significant implications for surgical treatment, Mukhtar explains.

• #102 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  The differential diagnosis of ILC with papillary features includes solid papillary carcinoma (SPC), encapsulated papillary carcinoma (EPC), the solid or alveolar variant of ILC, an ILC-SPC collision tumor, confluent growth of LCIS, and colonization of a papillary neoplasm by lobular carcinoma in situ. […] Tubular carcinoma, the tubulolobular variant of ILC, and mixed-type invasive breast carcinoma of NST and ILC may be considered in the differential diagnosis of ILC with tubular elements. […] The presence of tubular or pseudocribriform structures does not exclude a diagnosis of ILC, but an E-cadherin stain should be performed whenever these are present. […] The result of misdiagnosis in these cases can be the misclassification of an ILC as a mucinous carcinoma with a favorable prognosis. In contrast, ILC clinical behavior is more aggressive than mucinous carcinoma, characterized as initially indolent but slowly progressive. […] Careful examination of lesions with the abovementioned characteristics on small biopsy specimens may reveal morphological findings suggestive of ILC (presence of signet-ring cells, lack of cellular cohesion, limited areas with a single-file pattern) that may otherwise be missed.

• #103 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  The differential diagnosis of ILC with papillary features includes solid papillary carcinoma (SPC), encapsulated papillary carcinoma (EPC), the solid or alveolar variant of ILC, an ILC-SPC collision tumor, confluent growth of LCIS, and colonization of a papillary neoplasm by lobular carcinoma in situ. […] Tubular carcinoma, the tubulolobular variant of ILC, and mixed-type invasive breast carcinoma of NST and ILC may be considered in the differential diagnosis of ILC with tubular elements. […] The presence of tubular or pseudocribriform structures does not exclude a diagnosis of ILC, but an E-cadherin stain should be performed whenever these are present. […] The result of misdiagnosis in these cases can be the misclassification of an ILC as a mucinous carcinoma with a favorable prognosis. In contrast, ILC clinical behavior is more aggressive than mucinous carcinoma, characterized as initially indolent but slowly progressive. […] Careful examination of lesions with the abovementioned characteristics on small biopsy specimens may reveal morphological findings suggestive of ILC (presence of signet-ring cells, lack of cellular cohesion, limited areas with a single-file pattern) that may otherwise be missed.

• #104 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians. […] Many patients (52%) thought that their health care providers did not explain unique features of ILC. […] Patients and advocates also highlighted the need for improved diagnosis (imaging and pathologic analysis). […] The current World Health Organization (WHO) classification for ILC diagnosis only requires pathologists to note a non-cohesive growth pattern in the tumor and does not require analysis of E-cadherin status. […] Highlighting challenges in pathologic diagnosis of ILC, thirty-five pathologists diagnosed NST and ILC from a set of breast cancers and showed only a moderate inter-observer agreement, but a substantial agreement was found when E-cadherin was also used in the diagnosis. […] The top two most important research questions identified by clinician and laboratory researchers were 1) determining mechanisms of endocrine resistance, and 2) identifying novel therapeutic targets, repurposing existing drugs and progressing them to clinical trials.

• #105 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians. […] Many patients (52%) thought that their health care providers did not explain unique features of ILC. […] Patients and advocates also highlighted the need for improved diagnosis (imaging and pathologic analysis). […] The current World Health Organization (WHO) classification for ILC diagnosis only requires pathologists to note a non-cohesive growth pattern in the tumor and does not require analysis of E-cadherin status. […] Highlighting challenges in pathologic diagnosis of ILC, thirty-five pathologists diagnosed NST and ILC from a set of breast cancers and showed only a moderate inter-observer agreement, but a substantial agreement was found when E-cadherin was also used in the diagnosis. […] The top two most important research questions identified by clinician and laboratory researchers were 1) determining mechanisms of endocrine resistance, and 2) identifying novel therapeutic targets, repurposing existing drugs and progressing them to clinical trials.

• #106 Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer | Modern Pathology

  https://www.nature.com/articles/s41379-022-01135-2

  Invasive lobular carcinoma (ILC) represents the second most common subtype of breast cancer (BC), accounting for up to 15% of all invasive BC. […] Although the current world health organization (WHO) classification for diagnosing ILC requires the recognition of the dispersed or linear non-cohesive growth pattern, it is not mandatory to demonstrate E-cadherin loss by immunohistochemistry (IHC). […] Recent results of central pathology review of two large randomized clinical trials have demonstrated relative overdiagnosis of ILC, as only ~60% of the locally diagnosed ILCs were confirmed by central pathology. […] The results demonstrate that approximately half of the institutions use E-cadherin expression loss by IHC as an ancillary test to diagnose ILC and that there is a great variability in immunostaining protocols.

• #107 Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer | Modern Pathology

  https://www.nature.com/articles/s41379-022-01135-2

  Invasive lobular carcinoma (ILC) represents the second most common subtype of breast cancer (BC), accounting for up to 15% of all invasive BC. […] Although the current world health organization (WHO) classification for diagnosing ILC requires the recognition of the dispersed or linear non-cohesive growth pattern, it is not mandatory to demonstrate E-cadherin loss by immunohistochemistry (IHC). […] Recent results of central pathology review of two large randomized clinical trials have demonstrated relative overdiagnosis of ILC, as only ~60% of the locally diagnosed ILCs were confirmed by central pathology. […] The results demonstrate that approximately half of the institutions use E-cadherin expression loss by IHC as an ancillary test to diagnose ILC and that there is a great variability in immunostaining protocols.

• #108 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #109 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  The sensitivity rates for MRI range from 83% to 100%, with most studies reporting a sensitivity rate greater than 95%. […] The literature consistently reports MRI as the imaging modality with the strongest correlation of imaging to pathology tumor size estimate for ILC. […] One of the main benefits of including MRI as part of the diagnostic workup for patients newly diagnosed with ILC is the detection of additional ipsilateral and/or contralateral breast cancer. […] The prediction of nodal status is particularly important for patients with ILC after neoadjuvant therapy (NAC or NAE) as the upgrading or downgrading of axillary lymph nodes influences axillary surgery decisions. […] Our review of the literature finds that MRI and CEM clearly surpass US, DM, and DBT in terms of sensitivity, specificity, ipsilateral and contralateral detection, concordance, and estimation of tumor size and extent of disease within the breast for ILC. Importantly, both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup.

• #110

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  MRI is the most sensitive imaging modality for detecting ILC, with an overall sensitivity of approximately 93%. […] Emerging imaging modalities, such as contrast-enhanced mammography (CEM) and artificial intelligence (AI)-assisted imaging, are being explored to improve ILC detection further. […] As imaging technology advances, emerging modalities such as CEM, AB-MRI and AI-assisted detection hold promise for improving ILC detection and ensuring earlier diagnosis and better patient outcomes.

• #111

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  The sensitivity of mammography further declines in women with dense breast tissue, where ILC can remain masked by overlapping fibroglandular structures. […] To address these limitations, digital breast tomosynthesis (DBT) or 3D mammography, has been introduced as an adjunct to standard digital mammography (DM). […] DBT improves the conspicuity of ILC by reducing tissue overlap and enhancing the detection of architectural distortions. […] Despite these advances, a proportion of ILCs remains undetected, necessitating supplemental screening methods. […] Ultrasound (US) serves as a valuable supplemental imaging tool, particularly for women with dense breasts or those at increased risk of breast cancer. […] Studies have demonstrated that screening US detects additional ILCs after negative mammography or DBT findings.

• #112

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  MRI is the most sensitive imaging modality for detecting ILC, with an overall sensitivity of approximately 93%. […] Emerging imaging modalities, such as contrast-enhanced mammography (CEM) and artificial intelligence (AI)-assisted imaging, are being explored to improve ILC detection further. […] As imaging technology advances, emerging modalities such as CEM, AB-MRI and AI-assisted detection hold promise for improving ILC detection and ensuring earlier diagnosis and better patient outcomes.

• #113 New Study Backs Molecular Breast Imaging for Diagnosis of Invasive Lobular Carcinoma | Imaging Technology News

  https://www.itnonline.com/content/new-study-backs-molecular-breast-imaging-diagnosis-invasive-lobular-carcinoma

  Molecular breast imaging (MBI/BSGI) has been proven to be a highly sensitive imaging technique for the diagnosis of invasive lobular carcinoma (ILC), a position supported by a recent publication in the Journal of the American Medical Association Surgery. […] Physicians at the Legacy Cancer Institute in Portland, Oregon, reported a sensitivity of 88.9 percent for MBI/BSGI in diagnosing ILC, a difficult-to-diagnose breast cancer. […] The results show that BSGI has a slightly higher sensitivity for the detection of ILCs than for the detection of invasive ductal carcinomas (IDCs), while the specificities for both diseases are comparable. […] The group of physicians concluded that BSGI has high sensitivity and specificity and is an excellent adjunctive imaging tool for patients with newly diagnosed ILCs.

• #114

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  MRI is the most sensitive imaging modality for detecting ILC, with an overall sensitivity of approximately 93%. […] Emerging imaging modalities, such as contrast-enhanced mammography (CEM) and artificial intelligence (AI)-assisted imaging, are being explored to improve ILC detection further. […] As imaging technology advances, emerging modalities such as CEM, AB-MRI and AI-assisted detection hold promise for improving ILC detection and ensuring earlier diagnosis and better patient outcomes.

• #115 Invasive lobular carcinoma

  https://www.bcna.org.au/resource-hub/podcasts/upfront-about-breast-cancer/upfront-about-breast-cancer/episode-22-invasive-lobular-carcinoma/

  The algorithms, the deep learning means that the computer is presented with examples of a particular condition. In this case, it would be a breast cancer on a mammogram, maybe a lobular carcinoma on a mammogram. […] If it’s less obvious, it can present quite, quite late. […] Most lobular cancers are found when they’re fairly small. But of the cancers that are large, so throughout much of the breast at the time of diagnosis, lobular cancers are disproportionate. […] A number of patients I’ve seen have reflected and they’ve essentially said, look, something wasn’t quite right, but there wasn’t a lump and I couldn’t really feel something. […] The approach to treatment is very similar to the approach with the ductal carcinoma. […] Assessment in the breast is a little more difficult because as I said before, it’s not so much a lump. It can be diffuse.

• #116 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #117 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/breast-cancer/invasive-lobular-carcinoma-(lc)-

  This test measures how many HER2/neu breast cancer genes there are and how much HER2/neu protein is made in a sample of breast tissue. If there are more HER2/neu genes or higher levels of HER2/neu protein than normal, the cancer may grow or spread more quickly. […] Because no tumor has a single mutation, genomic profiling allows the pathologist (cellular expert) to identify groups of mutations in your tumor tissue sample. We then can create a tumor profile for you. That profile helps us determine what type of treatment would be the most effective and how long you should have treatment. […] Surgery can be used as a primary treatment or, it may be combined with other cancer therapies, depending on the diagnosis. Sylvester’s surgical oncologists are highly specialized in surgical options for breast cancer.

• #118 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #119 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is the second most common type of breast cancer. It is also known as invasive lobular carcinoma. […] Your GP may refer you to a breast clinic if you have any symptoms that could be due to invasive lobular breast cancer. You may also be referred to a breast clinic for tests if your screening mammogram shows an abnormal area. […] At the breast clinic the doctor or specialist nurse takes your medical history and examines your breasts. They also feel for any swollen (enlarged) lymph nodes under your arms and at the base of your neck. […] You usually have a number of tests to check for breast cancer including: a mammogram, an ultrasound, a biopsy, a breast MRI scan. […] There are many breast cancer trials. So your doctor might ask if you would like to take part in a clinical trial. […] Breast cancer research is looking at screening and diagnosis.

• #120 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Mouabbi hopes to open clinical trials at MD Anderson soon to investigate treating these cancers with immunotherapy. […] To define more personalized approaches, Mouabbi says its critical to conduct clinical trials specific to lobular breast cancer. […] If theres a clinical trial specific to lobular breast cancer, I urge patients to consider enrolling, Mouabbi says.

• #121 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #122 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Mouabbi hopes to open clinical trials at MD Anderson soon to investigate treating these cancers with immunotherapy. […] To define more personalized approaches, Mouabbi says its critical to conduct clinical trials specific to lobular breast cancer. […] If theres a clinical trial specific to lobular breast cancer, I urge patients to consider enrolling, Mouabbi says.

• #123 Managing the Differences between Invasive Lobular Breast Cancer (ILC) and Invasive Ductal Breast Cancer (IDC) | Cleveland Clinic

  https://my.clevelandclinic.org/podcasts/cancer-advances/managing-the-differences-between-invasive-lobular-breast-cancer-and-invasive-ductal-breast-cancer

  I think it will hopefully help patients have better quality of life and get treatment going faster. […] This is actually a great point, is that there are really no good national guidelines for the treatment of lobular cancer. […] And I think there are some potential pitfalls there. […] I do think so. I think all patients with lobular breast cancer, because it’s such a unique entity and because there’s still so much we don’t know, if a patient has the ability to be connected with a site that has experience with this type of cancer and expertise in it, or is interested in furthering our knowledge of it, I think it only benefits them as well as the doctors that treat lobular breast cancer for that engagement to happen.

• #124 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians. […] Many patients (52%) thought that their health care providers did not explain unique features of ILC. […] Patients and advocates also highlighted the need for improved diagnosis (imaging and pathologic analysis). […] The current World Health Organization (WHO) classification for ILC diagnosis only requires pathologists to note a non-cohesive growth pattern in the tumor and does not require analysis of E-cadherin status. […] Highlighting challenges in pathologic diagnosis of ILC, thirty-five pathologists diagnosed NST and ILC from a set of breast cancers and showed only a moderate inter-observer agreement, but a substantial agreement was found when E-cadherin was also used in the diagnosis. […] The top two most important research questions identified by clinician and laboratory researchers were 1) determining mechanisms of endocrine resistance, and 2) identifying novel therapeutic targets, repurposing existing drugs and progressing them to clinical trials.

• #125 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] Though mammograms are important for the early detection of breast cancer, they are less likely to detect ILC than other types of breast cancer. Because ILC grows in straight lines rather than in a mass or lump, it doesn’t always appear clearly on a mammogram. Therefore, a breast MRI may be needed to diagnose ILC. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently. ILC tends to invade breast tissue by spreading out in straight lines rather than amassing to form a solid clump or lump. Because ILC does not usually form into a solid lump, it is harder to detect through breast self-exams and mammograms. Therefore, other types of diagnostic tests and imaging in addition to a mammogram may be needed to diagnose ILC.

• #126 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. In addition, these breast cancers are also more likely to be multi-focal (occurring in more than one location) or bilateral (occurring in both breasts), which complicates accurate screening, detection, and treatment. […] Current research shows that MRI may be better able to detect lobular carcinoma than mammography, and new techniques are being developed, with several in clinical trials now. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment.

• #127 Lobular breast cancer series: imaging | Breast Cancer Research | Full Text

  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0605-0

  The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. […] However, advances in mammography, ultrasound, and magnetic resonance imaging present opportunities to improve the diagnosis and preoperative assessment of ILC. […] The low density of tumor cells and lack of desmoplastic stromal reaction in ILC account for the difficulty in its detection on physical examination, mammography, and even gross pathologic evaluation. […] Mammograms have been found to have a low sensitivity (57 to 79 %) in detecting ILC, with up to 30 % of cases not visualized at all on mammography, and 35 % of lesions only visible on one view. […] The sensitivity of mammography in detecting ILC is lower, ranging between 57 and 81 %.

• #128 Invasive Lobular Carcinoma: A Review of Imaging Modalities with Special Focus on Pathology Concordance

  https://www.mdpi.com/2227-9032/11/5/746

  The sensitivity rates for MRI range from 83% to 100%, with most studies reporting a sensitivity rate greater than 95%. […] The literature consistently reports MRI as the imaging modality with the strongest correlation of imaging to pathology tumor size estimate for ILC. […] One of the main benefits of including MRI as part of the diagnostic workup for patients newly diagnosed with ILC is the detection of additional ipsilateral and/or contralateral breast cancer. […] The prediction of nodal status is particularly important for patients with ILC after neoadjuvant therapy (NAC or NAE) as the upgrading or downgrading of axillary lymph nodes influences axillary surgery decisions. […] Our review of the literature finds that MRI and CEM clearly surpass US, DM, and DBT in terms of sensitivity, specificity, ipsilateral and contralateral detection, concordance, and estimation of tumor size and extent of disease within the breast for ILC. Importantly, both MRI and CEM have each been shown to enhance surgical outcomes in patients with newly diagnosed ILC that had one of these imaging modalities added to their preoperative workup.

• #129 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians. […] Many patients (52%) thought that their health care providers did not explain unique features of ILC. […] Patients and advocates also highlighted the need for improved diagnosis (imaging and pathologic analysis). […] The current World Health Organization (WHO) classification for ILC diagnosis only requires pathologists to note a non-cohesive growth pattern in the tumor and does not require analysis of E-cadherin status. […] Highlighting challenges in pathologic diagnosis of ILC, thirty-five pathologists diagnosed NST and ILC from a set of breast cancers and showed only a moderate inter-observer agreement, but a substantial agreement was found when E-cadherin was also used in the diagnosis. […] The top two most important research questions identified by clinician and laboratory researchers were 1) determining mechanisms of endocrine resistance, and 2) identifying novel therapeutic targets, repurposing existing drugs and progressing them to clinical trials.

• #130 Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9689338/

  Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and -catenin staining) features. […] ILC usually has a luminal A molecular phenotype and is often estrogen receptor (ER)- and progesterone receptor (PR)-positive and HER2 neu-negative, therefore being a prime candidate for hormonal therapy. It also shows a poor response to neoadjuvant therapy compared to invasive breast carcinoma of NST. […] ILC presents specific molecular characteristics compared to other subtypes of invasive breast carcinoma. […] This study aims to increase awareness of these rare variants of ILC. […] The differential diagnosis of ILC with extracellular mucin production includes invasive mucinous carcinoma of Capella type B, solid papillary carcinoma (SPC), mixed ILC and mucinous carcinoma, metaplastic matrix-producing carcinoma (MMPC), and polymorphous mammary adenocarcinoma.

• #131 What is Invasive Lobular Carcinoma | Breast Cancer Trials

  https://www.breastcancertrials.org.au/what-is-invasive-lobular-carcinoma/?srsltid=AfmBOooNwkYzzqlUKZ3kS8a2i5PtnqDzPrPNoI_TuSbPqd1AtIs-au6K

  If cancer is confirmed, the doctor may examine nearby lymph nodes to see if the cancer has spread. This is an important step in determining the extent or stage of the cancer. […] Understanding the stage of cancer is crucial for planning the most appropriate treatment. Staging considers the size of the tumour, whether it has spread to the lymph nodes, and whether it has spread to other parts of the body. […] ILC are typically oestrogen receptor positive breast cancers, which makes them sensitive to the endocrine (or hormone blocking) treatments such as tamoxifen. […] Depending on the stage of ILC, treatment may include a combination of surgery, radiation therapy, chemotherapy, endocrine (hormone) therapy, and targeted therapies. Treatment for ILC also may include breast surgery, radiation therapy and chemotherapy. In most cases, ILC is usually more responsive to endocrine therapy than chemotherapy and is generally preferred.

• #132 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because detection is challenging and patients dont see changes in their breast, 60% to 70% of patients diagnoses are changed to a higher stage after surgery. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] Most ILCs have high levels of the receptor for the female hormone estrogen. Patients with these cancers receive hormone therapy, which blocks the interaction of estrogen with the cancer cells estrogen receptors or lowers the bodys natural estrogen production. […] An accurate diagnosis is the first step in successful treatment for ILC. […] Imaging exams are used to look for cancer inside the body. […] Most ILCs are positive for the estrogen and progesterone receptors and negative for the HER2 receptor. […] Patients with suspected ILC will also be tested for the loss of E-cadherin. The absence of this molecule is a defining feature of the disease.

• #133 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Recent studies profiling lobular tumors suggest that some common genetic mutations cause a poorer response to hormone therapies and drive resistance. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] Researchers are striving to increase participation of patients with lobular breast cancer in clinical trials as well as designing clinical trials specifically focused on this subtypeachieving these goals is critical to advancing our understanding of lobular breast cancer and moving treatments and disease management forward. […] Progress in understanding the intricacies of the diseases biology has led researchers to develop new lobular carcinoma models for use in laboratory studies that subsequently inform new clinical trials. […] Advancements are also being made in early detection by using molecular tracers that recognize and attach to lobular breast cancer cells, making them easier to find with screening technologies.

• #134

  https://healthmanagement.org/s/invasive-lobular-carcinoma-detection-in-breast-cancer-screening

  MRI is the most sensitive imaging modality for detecting ILC, with an overall sensitivity of approximately 93%. […] Emerging imaging modalities, such as contrast-enhanced mammography (CEM) and artificial intelligence (AI)-assisted imaging, are being explored to improve ILC detection further. […] As imaging technology advances, emerging modalities such as CEM, AB-MRI and AI-assisted detection hold promise for improving ILC detection and ensuring earlier diagnosis and better patient outcomes.

Zobacz więcej