Materiały źródłowe

• #1 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Invasive lobular carcinoma (ILC) starts in the milk-producing glands in your breasts. It causes symptoms like breast pain, changes in your breast skin or discharge from your nipples. ILC can spread to many different areas of your body. […] As ILC grows slowly and may not form a lump, it may not cause noticeable changes in your breasts. When it does, symptoms can include: Breast pain or warmth, Breast skin that looks or feels thicker than usual or has dimples, tiny dents or puckers, Changes in breast size and shape, like an area of swelling or fullness, Inverted nipple that points into your breast instead of pointing out, Lump near your armpit, Nipple discharge, Skin discoloration that appears reddish or darker than usual. […] ILC can spread to other areas of your body many years after your diagnosis and treatment. […] You can develop metastatic invasive lobular carcinoma, which means it spreads to areas of your body far from your breast, 10 to 15 years after your diagnosis and treatment.

• #2 Invasive Lobular Carcinoma: Symptoms, Treatment, Research – Metastatic Breast Cancer AllianceLink to: Four Ways to Avoid Financial Toxicity from a Metastatic Breast Cancer Diagnosis (or Get Support to Cope)Link to: Sex and intimacy after breast cancerScro

  https://www.mbcalliance.org/guestblogposts/mbca-member-bcrf/invasive-lobular-carcinoma-symptoms-treatment-research/

  Invasive lobular carcinoma, also referred to as invasive lobular breast cancer (ILC) or simply lobular carcinoma/breast cancer, is the second most common type of breast cancer after invasive ductal carcinoma (IDC). The location where the cancer originates distinguishes ductal vs. lobular breast cancer: Invasive ductal carcinoma begins in milk ducts whereas invasive lobular carcinoma begins in lobules (the milk-producing glands of the breast). […] Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies.

• #3

  https://link.springer.com/article/10.1007/s40487-019-00105-0

  Invasive lobular breast cancer (ILC) accounts for 1015% of all breast cancers making it the second most common type of breast cancer behind invasive ductal carcinoma (IDC, also known as invasive carcinoma of no special type). […] Many studies show that ILC is associated with a good prognostic phenotype, i.e., well-differentiated (low grade), low-to-moderate proliferation index, hormone receptor positivity for both oestrogen receptor- (ER) and progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2)-negativity and basal marker negative status. […] Although the majority of ILC is ER-positive and responds well to endocrine therapy, retrospective clinical cohort studies show that long-term outcomes of ILC are equivalent or even inferior to that of IDC. […] ILC does not always present with a firm lump in the breast and therefore poses particular challenges for its detection clinically and/or via screening. Signs of ILC may include a thickened or swollen area in the breast with or without a change in the nipple shape (e.g., inverted nipple) and dimpling of the skin.

• #3

  https://link.springer.com/article/10.1007/s40487-019-00105-0

  In high-risk cases of primary disease in which patients receive adjuvant chemotherapy, there is evidence that ILC has an inferior prognosis than IDC, even after correcting for confounding factors such as patient age and breast cancer stage. […] There is evidence that adjuvant radiotherapy improves survival outcomes for patients with ILC. […] ILC has distinct morphological features that relate to key molecular hallmarks such as loss of E-cadherin, which can make diagnosis and surgical treatment more challenging compared with IDC.

• #4 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular breast cancer has distinct biological characteristics that set it apart from ductal carcinoma. […] The unique tumor growth patterns of lobular breast cancer are caused by a genetic alteration in the CDH1 gene that codes for E-cadherin, a protein that is essential for cell-to-cell adhesion that promotes normal tissue structure. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. […] Mammography and ultrasoundstandard breast imaging toolsare less reliable for early detection of lobular breast cancer or recurrent disease. […] Lobular breast cancer can recur and metastasize many years after diagnosis and treatment, so it is important to be aware of metastatic symptoms. […] Like other breast cancers, lobular carcinomas may be detected before a person feels any symptoms through regular breast cancer screenings.

• #5 Lobular breast cancer comes into the research spotlight | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/news/center-news/2018/02/lobular-breast-cancer-comes-into-the-research-spotlight.html

  Lobulars defining histological feature is its lack of a cell-to-cell adhesion protein known as E-cadherin, or CDH1. Instead of clustering together, lobular cells spread out single file like tree branches or spider webs or mesh, which explains why surgeons and oncologists often refer to it as sneaky or insidious. Because the cells dont stick together well, theres often no lump, making it harder for women to find during self-exams. Instead, they may notice a thickening or a small tuck as the skin is tugged from the inside. Lobular also tends to be multifocal, that is, patients often have more than one tumor per breast. […] This growth pattern also makes it difficult to find via imaging (if you have dense breasts, this can be a double whammy), so lobular tumors are often discovered at a later stage. Pate, who was diagnosed at stage 2b, said multiple mammograms missed her ILC tumor. Ultimately, it was found with ultrasound due to a neighboring lump created by ductal carcinoma in situ.

• #5 Lobular breast cancer comes into the research spotlight | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/news/center-news/2018/02/lobular-breast-cancer-comes-into-the-research-spotlight.html

  Lobulars metastatic spread is also unconventional. While ductal spreads to the liver, lungs, bones, and brain, lobular tends to go to the bones and ovaries or enmesh itself in the gastrointestinal tract, the abdominal lining, or the tissue around the kidneys and ureters. But lobular survivors arent always aware of this oddball spread pattern. Nor is it common knowledge among the primary care physicians who care for them years after treatment. This is especially problematic because lobular leans towards late recurrence. […] Several women in our [ILC] group had mets to the GI tract and the ovaries and never knew it was possible to spread there, said Pate. Lobular patients often have terrible problems getting diagnosed because imaging cant see the mets or their doctors misdiagnose their symptoms. Patients need to understand their disease so that if theyre having persistent issues with their ovaries or abdomen, they can advocate for themselves.

• #6 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Lobular breast cancer tends to spread to unusual sites, such as the lining of the gastrointestinal and urinary tracts. Patients often notice they feel constipated or have changes with urination. […] Because detection is challenging and patients dont see changes in their breast, 60% to 70% of patients diagnoses are changed to a higher stage after surgery. […] One of the hallmarks of lobular breast cancer is that it loses its anchoring protein, Mouabbi says. The cancer cells dont link with surrounding cells so they grow in lines. Eventually, the lines of cancer cells cross and interconnect to form a mass, but at that point, the cancer is advanced. […] Because the cancer doesnt grow as a mass, patients often cant feel it. Those who do report their breast feel denser or they see their nipple retract.

• #7 Invasive lobular carcinoma | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/invasive-lobular-carcinoma?content_id=CON-20373955

  At first, invasive lobular carcinoma may cause no signs and symptoms. As it grows larger, invasive lobular carcinoma may cause: A change in the texture or appearance of the skin over the breast, such as dimpling or thickening. A new area of fullness or swelling in the breast. A newly inverted nipple. An area of thickening in part of the breast. […] Invasive lobular carcinoma is less likely to cause a firm or distinct breast lump than other types of breast cancer. […] Invasive lobular carcinoma cells tend to invade breast tissue by spreading out rather than forming a firm lump. The affected area may have a different feel from the surrounding breast tissue. The area may feel more like a thickening and fullness, but it’s unlikely to feel like a lump.

• #8

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/invasive-lobular-carcinoma

  Invasive lobular carcinoma likely wont have symptoms. However, there are a few signs that could indicate a problem, such as: Thickening or hardening of breast tissue […] Changes in breast shape or size […] Breast pain or discomfort […] Nipple changes […] Nipple discharge […] Swelling of the breast or arm. If you notice any persistent changes in your breast health or experience any of the symptoms mentioned above, schedule an appointment with your doctor for further evaluation.

• #9 What Is Lobular Carcinoma? MSK Doctors Explain | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/news/what-is-lobular-breast-cancer-msk-doctors-explain

  People with LBC might feel a vague sensation, fullness, engorgement, or firmness in their breasts, or notice redness, skin or nipple changes, or discharge from the nipple, says Dr. Mamtani. Those are the most common signs in patients with an advanced lobular breast cancer that’s been hiding in their breast for a long time. […] When LBC is caught early, most people will have no symptoms, adds Dr. Mamtani. […] LBC grows in a way that’s not cohesive, so people are less likely to feel a mass or nodule, and it’s not easily detected on screening mammograms, says Dr. Shen. As a result, some people are diagnosed at a later stage when the tumor is bigger. […] Lobular breast cancers are sneaky, adds Dr. Mamtani. Both their size and lymph node involvement tend to be notoriously underestimated on scans and during breast exams. […] Despite this characteristic of LBC, with appropriate screening, most lobular carcinomas can still be detected at an early stage.

• #10 Invasive lobular carcinoma | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/invasive-lobular-carcinoma?content_id=CON-20373955

  At first, invasive lobular carcinoma may cause no signs and symptoms. As it grows larger, invasive lobular carcinoma may cause: A change in the texture or appearance of the skin over the breast, such as dimpling or thickening. A new area of fullness or swelling in the breast. A newly inverted nipple. An area of thickening in part of the breast. […] Invasive lobular carcinoma is less likely to cause a firm or distinct breast lump than other types of breast cancer. […] Invasive lobular carcinoma cells tend to invade breast tissue by spreading out rather than forming a firm lump. The affected area may have a different feel from the surrounding breast tissue. The area may feel more like a thickening and fullness, but it’s unlikely to feel like a lump.

• #11 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  Invasive lobular breast cancer doesn’t always form a firm lump. You are more likely to have a thickened area of breast tissue. […] Possible symptoms include: an area of thickening or swelling, a change in the nipple, for example it might turn inwards (become inverted), a change in the skin, such as dimpling or thickening. […] While invasive lobular breast cancer can cause these particular symptoms, its worth being aware of the general symptoms of breast cancer.

• #12 Lobular Breast Cancer: Here’s What You Need To Know – Ezra

  https://ezra.com/blog/lobular-breast-cancer

  Lobular breast cancer is a type of invasive breast cancer often referred to as invasive lobular carcinoma (ILC). Invasive breast cancer means the cancer cells have moved outside of the lobule of the breast. […] You most likely wont initially see symptoms of early lobular breast cancer, but breast changes can occur as the cancer grows. These changes include: Thickening (or toughening) in part of the breast, Fullness or swelling (enlargement) in the breast, Dimpling or thickening of the skin of the breast, Nipple inversion that was not previously there. […] It’s important to note that lobular breast cancer is less likely to form a distinct lump often associated with identifying breast cancer. […] If you notice any of these symptoms, it’s important to see your healthcare provider so they can do a full medical exam and schedule testing. […] As with all cancers, early detection is key to improving treatment options so you can move on to enjoying life. Since lobular breast cancer doesn’t create the classic lump many women are taught to look for, routine screening can identify cancer sooner, while it’s still in the early stages.

• #13 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Invasive lobular carcinoma symptoms tend to be similar to other breast cancers, but the structure of its formation is what sets it apart. […] The most common invasive lobular carcinoma symptoms are: Hardened or thickened area inside the breast or underarm, Dimpling, dent, or puckering of the skin of a breast, Change in the size or shape of a breast, Changes to the nipple, including inversion or pulling to one side, A new area of fullness or swelling in the breast. […] Metastatic lobular breast cancer symptoms include: Unexplained and persistent bone pain, especially in the back, ribs, or thighs, Unusual pelvic bleeding, Abdominal pain, distention and/or bloating, Difficulty eating or digesting food, Unexplained weight loss, Unexplained shortness of breath or painful breathing, Frequent headaches, dizziness, or impaired cognitive function, Swelling or lumps in the chest, armpit, neck, or groin, Changes in skin color, lasting rash, or firm nodules on the skin, New difficulty seeing.

• #14 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is a type of cancer that affects the cells of the lobules (milk-producing glands) of the breast. […] Symptoms of invasive lobular breast cancer include: A thickening of the breast tissue, A change in the shape or size of the breast, A change of skin texture such as puckering or dimpling, A lump or swelling under the arm, Changes to the nipple, Discharge from the nipple, A breast lump (although this is less common). […] Invasive lobular breast cancer may not cause any obvious changes to the breast. […] You may be diagnosed with invasive lobular breast cancer during routine breast screening before you have noticed any symptoms. However, lobular breast cancer can be more difficult to see on a mammogram than other types of breast cancer. […] Secondary invasive lobular breast cancer can affect the digestive organs (stomach and intestine), reproductive organs (uterus and ovaries), lungs, liver, bones, brain, and skin. […] Its important to be aware of the signs and symptoms of secondary breast cancer.

• #15

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/invasive-lobular-carcinoma

  Invasive lobular carcinoma starts within the milk glands (lobules) of your breast, and later invades surrounding breast tissue and possibly other parts of your body. […] Unlike some other types of breast cancer, ILC grows in a scattered pattern and may not present as a distinct lump. This creates challenges in detection with imaging tests like mammograms or self-exams. […] If you have invasive lobular carcinoma, you may not experience any noticeable signs or symptoms. However, some signs of an issue may be visible that should be checked by your doctor. […] ILC symptoms may include: Breast pain or discomfort, Changes in breast shape or size, Changes in the skin of the breast, Nipple discharge, Swelling of the breast or arm, Thickening or hardening of breast tissue. […] If you notice any abnormal changes in your breast health, schedule an appointment with your doctor for further evaluation.

• #16 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma typically invades breast tissue by spreading out through the breast, growing in straight lines, rather than forming a tight clump or lump. Though not all breast cancer presents tangible symptoms, the signs and symptoms of invasive lobular carcinoma, if present, may include: […] A hard or thickened area in the breast tissue or underarm area (as opposed to a hardened lump) […] Any unexplained change in the size or shape of the breast, including swelling or shrinkage (especially if on one side only) […] Dimpling anywhere on the breast […] Puckering in the skin of the breast […] A nipple turned inward (inverted) into the breast […] Discharge (fluid) from the nipple (particularly clear or bloody discharge) […] A change in the skin texture, discoloration, swelling, or an enlargement of pores in the skin of the breast (some describe this as similar to an orange peel’s texture)

• #16 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Scaly, red, swollen, or unusually warm skin on the breast, nipple, or areola […] Recent asymmetry (unequal or lack of sameness) of the breasts. […] Because it is difficult to detect through early screening methods, invasive lobular carcinoma can grow large and spread before it is diagnosed, often leading to ILC being diagnosed at a later stage than other breast cancers. […] Although invasive lobular carcinoma is a slow-growing cancer, it tends to be diagnosed at a later stage because it is harder to detect through mammogram alone. Therefore, breast MRI continues to be the best way to screen for and detect invasive lobular carcinoma. […] Stage 4 invasive lobular carcinoma (also called metastatic breast cancer) means that the cancer has spread (metastasized) to distant areas or organs of the body. Unlike other types of invasive breast cancer that commonly spreads to the bones, liver, lungs, and brain, ILC tends to metastasize to the colon, uterus, ovaries, and stomach.

• #17 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because detection is challenging and patients dont see changes in their breast, 60% to 70% of patients diagnoses are changed to a higher stage after surgery. […] The symptoms of ILC include: A breast that feels swollen, thick or full, A newly inverted nipple, Skin dimpling, An orange peel texture on breast skin, Nipple discharge, A red, scaly nipple. […] These symptoms do not always mean you have breast cancer. However, it is important to discuss any symptoms with your doctor, since they may also signal other health problems.

• #17 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Unlike ductal carcinomas, ILCs usually do not form a lump. Instead, the cancer cells grow in straight lines. This makes them harder to feel during a physical breast examination. In many cases, patients do not notice the growth until these lines of cancer cells intersect and form a mass. […] When ILC spreads, or metastasizes, it often moves into gastrointestinal tract, ovaries, peritoneum, retroperitoneum and leptomeninges (part of the membrane that surrounds and protects the brain and spinal cord). […] Lobular breast cancer tends to spread to unusual sites, such as the lining of the gastrointestinal and urinary tracts. Patients often notice they feel constipated or have changes with urination.

• #18 Invasive breast cancer symptoms

  https://www.cancercenter.com/cancer-types/breast-cancer/types/common-breast-cancer-types/invasive-breast-cancer

  Invasive lobular carcinoma, or ILC, begins in the breast lobules, or glands that make milk. ILC is less common than IDC. […] While not everyone experiences symptoms when diagnosed with invasive breast cancer, its important to be aware of potential symptoms. Invasive breast cancer symptoms may include: Changes to the skin on and around the breast, including redness, dimpling, puckering or unexplained rash. Fluid discharge from the nipple. A lump in or around the breast or armpit. A change in the shape or feel of the breast. […] Seeking medical advice about any unexpected changes to the breasts is key to identifying issues as early as possible.

• #19 Breast Cancer | Breast Cancer Symptoms | MedlinePlus

  https://medlineplus.gov/breastcancer.html

  The signs and symptoms of breast cancer include A new lump or thickening in or near the breast or in the armpit. […] A change in the size or shape of the breast. […] A dimple or puckering in the skin of the breast. It may look like the skin of an orange. […] A nipple turned inward into the breast. […] Nipple discharge other than breast milk. The discharge might happen suddenly, be bloody, or happen in only one breast. […] Scaly, red, or swollen skin in the nipple area or the breast. […] Pain in any area of the breast.

• #20 What is Invasive Lobular Carcinoma | Breast Cancer Trials

  https://www.breastcancertrials.org.au/what-is-invasive-lobular-carcinoma/?srsltid=AfmBOormLTBEnF64mwC5AiEq8H9ZH_xMcf6DaPKzYh0UAV5l_NDmoCxI

  Some patients diagnosed with ILC may not present with any symptoms. When symptoms are present, they may include: […] A new lump in the breast, armpit area or around the collarbone. […] Thickening or hardening in the breast. […] A change in breast size or shape. […] Changes to the nipple, such as sores or crusting, an ulcer or inverted nipple. […] Clear or bloody nipple discharge. […] Changes to the skin including redness, puckering or dimpling (an orange peel appearance). […] Breast tenderness or pain.

• #21 Stage 3 Breast Cancer Overview – National Breast Cancer Foundation

  https://www.nationalbreastcancer.org/breast-cancer-stage-3/

  Stage 3 breast cancer is also called locally advanced breast cancer, meaning that the cancer is invasive and has spread out of the immediate, or local, area in the breast and into the lymph nodes or muscles close to the breast. […] Because Stage 3 breast cancer is considered advanced breast cancer, it may present some physical symptoms, such as a lump in the breast that can be felt, or changes to the breast shape, size, or skin texture. There may also be lumps felt in the underarm area. […] Signs and symptoms of Stage 3 breast cancer may include: A change in the skin texture or enlargement of the pores in the skin of the breast (some describe this as similar to the texture of an orange peel), including dimpling, redness, or scaliness; Ulcerated skin on the breast (an open sore or a break in the skin); Breast pain, itchiness, or irritation; A lump in the breast and/or armpit; Changes to the size or shape of the breast, including swelling of the breast; Changes in the nipple, such as peeling or flaking, or an inverted nipple; Nipple discharge, which can be clear, cloudy, or bloody. […] Not all breast cancer causes symptoms that can be felt or observed. However, since Stage 3 breast cancer is a locally advanced cancer, signs and symptoms may begin to appear.

• #22 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  You might not notice symptoms at first. If you do, they can include: Thickening or hardening in the breast (rather than a distinct lump) […] A change to the texture of skin on your breast or nipple, such as dimples or an irritated, red, or scaly area […] A nipple that turns inward […] Pain in your breast or nipple […] Unusual nipple discharge […] A lump under your arm. […] Invasive lobular carcinoma is breast cancer that begins in the cells of the mammary glands that make milk, called lobules, and spreads to other parts of the breast. It’s the second most common type of breast cancer in the US that often grows slowly, but can be hard to detect. […] In general, about 91% of all women with breast cancer live at least five years after diagnosis. While there isn’t much information about specific types of breast cancer, these survival rates are tracked by stage at diagnosis or how far the cancer has spread: Localized (cancer hasn’t spread outside the breast): More than 99% live at least five years […] Regional (cancer has spread to lymph nodes near the breast): 87% live at least five years […] Distant (cancer has spread farther in the body): 32% live at least five years.

• #23 Invasive lobular carcinoma symptoms, treatments & forums | PatientsLikeMe

  https://www.patientslikeme.com/conditions/invasive-lobular-carcinoma

  Invasive lobular carcinoma is a type of breast cancer that begins in the milk producing glands (lobules) and has invaded the tissue of the breast. […] Common symptom: Fatigue. […] Common symptom: Stress. […] Common symptom: Depressed mood. […] Common symptom: Anxious mood. […] Common symptom: Pain.

• #24 Invasive Lobular Carcinoma (ILC): Causes, Symptoms & Treatment

  https://www.ganeshdiagnostic.com/blog/invasive-lobular-carcinoma-ilc-causes-symptoms-and-treatment

  ILC often grows in a linear or ribbon-like pattern, which can cause cancer to spread out instead of forming a distinct mass. […] ILC can also be invasive as it may metastasize to several parts of the body including lymph nodes, bones, liver, or lungs. […] ILC can be more difficult to detect on imaging than other subtypes of breast cancer because it tends to grow in a diffuse, linear pattern rather than as a well-defined mass. As a result, ILC may be more likely to be diagnosed at a later stage. […] A breast lump or armpit thickening: This is often the first sign of breast cancer, but not all breast lumps are cancerous. […] Changes in breast size or shape: The affected breast may become larger or smaller or change in shape. […] Changes in the nipple or areola: This may include nipple inversion (when the nipple is pulled inward instead of pointing outward), discharge from the nipple, or changes in the skin around the nipple or areola.

• #25 What is Invasive Lobular Carcinoma?

  https://info.iowaradiology.com/what-is-invasive-lobular-carcinoma

  ILC may not produce any noticeable symptoms, which makes regular screening mammograms essential in detecting this form of cancer as early as possible. In some cases, however, patients may experience a thickening or hardening in the breast (as opposed to a distinct lump), an area of swelling or fullness, irritation or dimpling of the skin on the breast, or the inversion of a nipple. […] Because of its unusual growth pattern, ILC can be difficult to identify on a mammogram. Rather than forming a lump, ILC cells tend to invade surrounding tissue in a line.

• #26 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. […] Invasive lobular cancer tends to stay clinically silent and escapes detection on a mammogram or physical examination until the disease is detected at advanced stages. This is secondary to the indolent growth and to the pattern of infiltrative growth of this neoplasm, which makes early diagnosis difficult with a mammogram. […] Patients with invasive lobular carcinoma present with a mass or vague, diffuse nodularity. They are also detectable by mammographic breast screening. […] The challenge with invasive lobular carcinomas is that they can be difficult to detect clinically and radiographically, and consequently tend to be larger at the time of diagnosis.

• #26 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  The most frequent manifestation of invasive lobular carcinoma is an enhancing solitary nodule with spiculated or ill-defined margins. […] Older age (aged 60 years) of the patients, larger tumor size, and metastatic axillary lymph node involvement have been suggested as poor prognostic factors. […] A lower frequency of axillary nodal metastasis in invasive lobular carcinoma than in invasive carcinoma of no special type has been reported in some series, the difference ranging from 3% to 10%. […] Metastases of invasive lobular carcinoma differ from those of invasive carcinoma of no special type. A higher frequency of tumor extension to the bone, gastrointestinal tract, uterus, meninges, ovary, and diffuse serosal involvement is observed in invasive lobular carcinoma, while the extension to the lung is more frequent in invasive carcinoma of no special type.

• #27 ILC Facts – The Lobular Breast Cancer Alliance

  https://lobularbreastcancer.org/ilc-fact-sheet/

  While lobular breast cancer, like IDC/NST, can recur any time after initial diagnosis, studies show that ILC often recurs later than IDC, more than 10 years after the initial diagnosis of cancer. […] Since ILC typically grows in a linear pattern through the breast without distorting the surrounding structures or forming a lump, ILC is more difficult to detect than IDC on mammography and ultrasound or to visualize when metastatic. ILC is often missed in routine screening resulting in larger and later stage tumors when detected and diagnosed.

• #27 ILC Facts – The Lobular Breast Cancer Alliance

  https://lobularbreastcancer.org/ilc-fact-sheet/

  Lobular breast cancer, also known as invasive lobular carcinoma (ILC), is the second most common histological type of breast cancer diagnosed, accounting for about 10-15% of all breast cancers. An estimated 43,000 new cases of ILC are diagnosed each year. ILC impacts more women than do cancers of the kidney, brain, pancreas, liver, or ovaries. […] Symptoms of ILC tumors can range from none to changes in the appearance of the nipple or breast, such as dimpling, hardening of the breast, swelling, or pain. On self-examination, ILC can sometimes be felt as a firmness or mass. […] Similar to IDC/NST, ILC can metastasize to the bones, brain, liver, and lungs. However, ILC can also spread to unique sites such as the gastrointestinal tract (stomach, small intestine, and colon), gynecological organs (ovaries, uterus), the peritoneum (abdominal lining), and in rarer cases leptomeninges (lining of the brain and spinal cord) and orbital tissues (tissues around the eye).

• #28 Invasive lobular cancer – anyone else had imaging issues? – Macmillan Online Community

  https://community.macmillan.org.uk/cancer_types/breast-cancer-forum/f/questions-about-diagnosis-and-treatment/245310/invasive-lobular-cancer—anyone-else-had-imaging-issues

  I have been reading up on this type of cancer and am aware it advises Imaging remains a big problem for lobular tumors, both in the primary cancer setting as well as in the metastatic setting. It is clearly not picked up by traditional imaging approaches. […] Due to the above, I now am having a mastectomy. This is because my cancer only appeared faintly on the ultrasound. […] I have had Invasive Lobular cancer and 10 out of 14 lymph node involvement. […] My main worry is I have an annual mamagram but this type does not show well on this. […] I felt a lump but had a regular mammogram already booked. […] Lobular is so difficult to find.

• #29 Invasive Lobular Carcinoma | AdvancedBreastCancer.netShare to Facebookprint pageBookmark for latercommentcaret iconFollow us on facebookFollow us on instagramFollow us on facebookFollow us on linkedincaret icon

  https://advancedbreastcancer.net/living/understanding-ilc

  ILC may not have any symptoms at first. In some cases, an abnormal area may show up on an imaging test. However, ILC is usually harder to see on a mammogram than IDC. This is because instead of forming a lump, IDC cells usually spread in a line formation. […] Sometimes a thickening or hardening is felt, rather than a formed lump. Other symptoms can include: Area of fullness or swelling, Change in texture of the skin, Nipple turning inward, Breast and/or nipple pain, Nipple discharge, Lump in the underarm area. […] With ILC, there is often more than 1 area of cancer in the breast. It is also more likely than other types of breast cancer to be in both breasts, rather than just 1.

• #30 Invasive Breast Cancer (IDC/ILC) | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/invasive-breast-cancer.html

  About 1 in 10 invasive breast cancers is an invasive lobular carcinoma (ILC). […] Invasive lobular carcinoma may be harder to detect on physical exam and imaging, like mammograms, than invasive ductal carcinoma. […] And compared to other kinds of invasive carcinoma, it is more likely to affect both breasts. About 1 in 5 women with ILC might have cancer in both breasts at the time they are diagnosed.

• #31 Invasive Lobular Carcinoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/ilc.html

  Invasive lobular carcinoma (ILC) tumors do not usually form in lumps and are hard to image with screening tests or to feel in self-exams. […] Symptoms of ILC tumors can range from none to changes in the appearance of the nipple or breast, such as dimpling, hardening of the breast, swelling, or pain. […] Because the tumors are harder to image and feel, lobular breast cancer is often only diagnosed once tumors are larger than 2cm and later stage, and sometimes already metastatic. […] Many scientific studies have confirmed that lobular breast cancer is a distinct breast cancer type and that it behaves differently from the more common non-lobular breast cancers. […] Like IDC/NST, ILC can metastasize to the bones, brain, liver, and lungs. However, ILC can also spread to unique sites such as the gastrointestinal tract (stomach, small intestine, and colon), gynecological organs (ovaries, uterus), the peritoneum (abdominal lining), and in rarer cases leptomeninges (lining of the brain and spinal cord) and orbital tissues (i.e., around the eye). […] Though ILC is hardly a rare cancer, at 15% of breast cancers, for decades, in part because of the smaller numbers of patients at any one site and the insufficient standardization of the diagnosis for pathologists and radiologists, there has been very little research.

• #32 Mutations Matter: Unravelling the Genetic Blueprint of Invasive Lobular Carcinoma for Progression Insights and Treatment Strategies

  https://www.mdpi.com/2072-6694/16/22/3826

  Invasive Lobular Carcinoma (ILC) presents a distinct subtype of breast cancer, representing 10–15% of cases, with unique clinical and molecular features. Characterized by a non-cohesive, single-file invasion pattern, ILC is typically estrogen receptor (ER)- and progesterone receptor (PR)-positive but human epidermal growth factor receptor 2 (HER2)-negative. Despite favorable prognostic features, its highly metastatic nature and predilection for atypical sites contribute to lower long-term survival compared to invasive breast carcinoma of no special type (NST). […] The typical scenario for ILC tumors displays favorable prognostic features, for instance, ER-positivity and slow proliferation rates. However, long-term overall survival tends to be lower for ILC, compared to NST patients. This is due largely to the highly metastatic nature of the disease, which forms a very distinct pattern. Compared to NST, ILC tumors present metastases to the skeleton, gastrointestinal tract, peritoneum and gynecological sites, such as the myometrium, endometrium, cervix, and ovaries, more frequently.

• #33

  https://mantacares.com/blogs/newsletter/how-common-is-invasive-lobular-carcinoma?srsltid=AfmBOors2C3B0DeDHfBXbxZ8e1IVG6lpmcYHSTMAqsE6nONmTP1f08rX

  Invasive lobular carcinoma (ILC) often doesn’t form a noticeable lump, which is what many people look for when they think of breast cancer. Instead, you might notice a thickening or fullness in one part of your breast, changes in the texture or appearance of your breast skin, or a newly inverted nipple. […] Symptoms of lobular breast cancer can include a thickening or hardening in the breast, changes in the texture or appearance of the breast skin, and a newly inverted nipple. It can, but may not not form a noticeable lump like other breast cancers. […] Invasive lobular carcinoma tends to grow slowly and spread less aggressively compared to some other types of breast cancer. However, it can be harder to detect early, which can sometimes make it more challenging to treat.

• #34 Lobular Breast Cancer Prognosis and Survival Rates

  https://www.healthline.com/health/breast-cancer/lobular-breast-cancer-prognosis-survival

  Lobular breast cancer symptoms may include a thickening or hardening of your breast (which can feel different from a lump), swelling, skin texture changes, dimpling, an inverted nipple, and breast or nipple pain. […] ILC tumors may spread aggressively and tend to be relatively large. […] ILC is most often diagnosed at a more advanced stage.

• #35 Metastatic Breast Lobular Carcinoma to Unusual Sites: A Report of Three Cases and Review of Literature | Abdallah | Journal of Medical Cases

  https://www.journalmc.org/index.php/JMC/article/view/3538/2866

  Invasive lobular carcinoma of the breast is the second most common type of invasive breast carcinoma. Invasive lobular carcinoma has an unusual pattern of metastases, which poses a diagnostic challenge for both clinicians and pathologists. […] We recommend a higher index of suspicion in any case with breast cancer developing gastrointestinal tract or genital tract symptoms. […] Breast invasive lobular carcinoma has a high frequency of distant metastases. The most common sites of metastases are the bone, lung, pleura, soft tissue and liver. Metastases to the female genital tract are rare; and metastases to the gastrointestinal (GI) tract are even rarer. […] Clinically, metastatic invasive lobular carcinoma to the GI tract has a similar presentation to primary GI malignancies, and immunohistochemistry is essential to verify whether the tumor is primary or a metastatic.

• #35 Metastatic Breast Lobular Carcinoma to Unusual Sites: A Report of Three Cases and Review of Literature | Abdallah | Journal of Medical Cases

  https://www.journalmc.org/index.php/JMC/article/view/3538/2866

  We concluded that a thorough workup and a higher suspicion index of metastases should be adopted in cases with history of or current breast carcinoma, especially if it is of the invasive lobular carcinoma type, when developing GI tract or genital tract symptoms. […] Abnormal vaginal bleeding has been repeatedly reported as the manifestation of metastatic invasive lobular carcinoma to the uterus. […] Invasive lobular carcinoma was associated with larger tumor size, older age, later stage, lower grade, ER/PR positive and negative HER2, which were the characteristics of our three cases. […] Our recommendations is to have a higher index of suspicion in any case with a history of current breast cancer, especially invasive lobular carcinoma when developing GI tract or genital tract symptoms, even if mild or subtle, and to biopsy any developed GI tract or genital tract lesions with performing an extensive immunostaining panel including breast specific antibodies.

• #36 Gastrointestinal metastasis secondary to invasive lobular carcinoma of the breast: A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9477019/

  Gastrointestinal metastasis of breast cancer is rare, and clinicians may not have previously encountered this disease in clinical practice. […] We report a patient with invasive lobular carcinoma of the breast who developed gastrointestinal metastasis two years after modified radical surgery. Mild elevation of carbohydrate antigen 15-3 was observed in the patient at an early stage; however, diagnosis and treatment were delayed due to non-specific clinical manifestations and no identifiable metastasis observed on imaging. […] Clinicians should pay attention to gastrointestinal metastasis of breast cancer, especially invasive lobular carcinoma of the breast. […] Gastrointestinal metastasis of breast cancer should be vigilant when tumor markers are elevated or when patients have digestive symptoms such as abdominal distention and defecation difficulties of unknown cause. Early detection, diagnosis, and treatment are needed to prevent disease progression and complications.

• #36 Gastrointestinal metastasis secondary to invasive lobular carcinoma of the breast: A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9477019/

  The patient had no specific clinical symptoms at the early disease stage of the disease, with only the tumor marker CA15-3 being slightly higher than the normal upper limit, and no tumor metastasis found on imaging examination. […] If tumor markers increase postoperatively and other causes are excluded, and metastatic lesions cannot be detected using conventional imaging, clinicians should be alerted to the possibility of digestive tract metastasis or metastases at other rare sites should be kept on alert.

• #37 Lobular Breast Cancer: Symptoms, Treatments & More

  https://www.healthline.com/health/breast-cancer-lobular

  Invasive lobular carcinoma is a common type of breast cancer that can spread to other parts of the body. Early diagnosis and treatment can help improve the long-term outlook for this condition. […] ILC develops differently from more common types of breast cancer. Its less likely to have obvious lumps. In the early stages, there could be no signs or symptoms. But as the cancer grows, you may notice your breasts: thickening or hardening in a certain area, swelling or feeling full in a certain area, changing in texture or skin appearance, such as dimpling, developing a newly inverted nipple, changing in size or shape. […] These are usually the first signs of breast cancer, including ILC. See a doctor if you notice these signs or symptoms. […] Like IDC, if ILC spreads, it tends to show up in the lymph nodes, bones, liver, lungs, and brain. Unlike IDC, ILC is more likely to spread to unusual places like the stomach and intestines, abdomen lining, and reproductive organs.

• #37 Lobular Breast Cancer: Symptoms, Treatments & More

  https://www.healthline.com/health/breast-cancer-lobular

  Early diagnosis and advances in treatment help increase your chance of living a long and healthy life. The long-term outlook of ILC depends on multiple factors, such as the stage of cancer, grade and subtype, surgical margins, or how close the cancer cells are to the tissue removed from the breast, your age, your overall health, and how well you respond to treatment.

• #38 Invasive Lobular Breast Cancer – Susan G. Komen®

  https://www.komen.org/breast-cancer/diagnosis/invasive-lobular-breast-cancer/

  This may explain some of the difference in longer-term breast cancer survival between women with ILC and women with IDC. […] Survival 10 years after diagnosis tends to be worse for women with ILC than for women with IDC. […] The most important factors related to survival for ILC are cancer stage and tumor grade. […] While invasive lobular cancer (ILC) can metastasize to these sites, it can also spread to sites not common with other breast cancers. […] For example, ILC sometimes may metastasize to the ovaries or the gastrointestinal tract (including the stomach, colon and rectum).

• #38 Invasive Lobular Breast Cancer – Susan G. Komen®

  https://www.komen.org/breast-cancer/diagnosis/invasive-lobular-breast-cancer/

  The warning signs of invasive lobular cancer are the same as for other breast cancers. […] If you notice any change in your breast or underarm area, see your health care provider. […] In the first 5 years after diagnosis, hormone receptor-positive breast cancers (such as most ILC) tend to have a lower risk of breast cancer recurrence than hormone receptor-negative breast cancers (such as some IDC). […] So, in the first 5 years after diagnosis, women with hormone receptor-positive cancers tend to have better breast cancer survival than women with hormone receptor-negative cancers. […] Similarly, women with ILC tend to have better survival in the first 5-10 years after diagnosis than women with IDC. […] Hormone receptor-positive breast cancers can recur more than 10 years after diagnosis, while such late recurrences are rare for hormone receptor-negative cancers.

• #39 Diagnosis | Lobular Breast Cancer UK

  https://lobularbreastcancer.org.uk/diagnosis/

  Lobular Breast Cancer that has metastasised (spread) to other parts of the body can be similar in pattern to other breast cancers. Once it leaves the breasts, it may travel to the lymph nodes, bones, lungs, liver and brain but it can also be found in more unusual places. […] Lobular cells can lie dormant for many years and are more likely to recur 10 15 years after the initial diagnosis. […] Report any unusual symptoms you may experience to your medical team, such as: persistent pain or bone pain, headaches and dizziness, a hardening in your original scar, breast or chest, unusual fatigue, a rash that does not clear, new skin nodules.

• #40 Invasive lobular carcinoma

  https://www.bcna.org.au/resources/podcasts/upfront-about-breast-cancer/upfront-about-breast-cancer/episode-22-invasive-lobular-carcinoma/

  Most lobular cancers are HER2-negative. […] Most lobular cancers are grade 2. […] If you’ve got a case, a woman has a cancer that is likely to be chemotherapy resistant, we are generally fairly reluctant to start with chemotherapy. […] If the breast feels different, if something’s wrong, make sure you’re treated, assess, treated seriously and assessed properly. […] When, if someone unfortunately has a cancer and it’s a lobular cancer, it’s not the end of the world. These are highly treatable, successfully treated in most cases.

• #40 Invasive lobular carcinoma

  https://www.bcna.org.au/resources/podcasts/upfront-about-breast-cancer/upfront-about-breast-cancer/episode-22-invasive-lobular-carcinoma/

  Lets be Upfront about invasive lobular carcinoma. The second most common form of invasive breast cancer, picking up lobular carcinoma on mammograms can be difficult as they often dont present as a lump in the breast. […] Invasive lobular carcinoma is actually the second most common type of breast cancer. […] Lobular carcinomas can be difficult to see on mammograms. […] The lobular carcinomas, they tend to spread. They tend to be diffuse. So the cancer cells will spread through the normal breast tissue and they don’t form a lump the same way as ductal carcinomas tend to. […] When you asked earlier, is it worse? My answer was specific. It’s for the same size, for the same nodes, it’s no worse. But if it’s less obvious, it can present quite, quite late. […] Given that it doesn’t typically present as a lump. Does it quite often results in that type of breast cancer being diagnosed further advanced?

• #40 Invasive lobular carcinoma

  https://www.bcna.org.au/resources/podcasts/upfront-about-breast-cancer/upfront-about-breast-cancer/episode-22-invasive-lobular-carcinoma/

  I think this is where the advice of 'if something’s not right, make sure it’s checked properly.’ […] A number of patients I’ve seen have reflected and they’ve essentially said, look, something wasn’t quite right, but there wasn’t a lump and I couldn’t really feel something. […] The affected breast is different from the other. But within that breast, there is no single lump. There’s nothing to say, Look, you know, here is the spot that’s abnormal It’s just the whole thing. […] If someone has a cancer in one breast, the other breast must be closely assessed with appropriate examination and imaging because bilateral cancer can occur, but it can occur in any situation. […] The approach to treatment is very similar to the approach with the ductal carcinoma. […] Most lobular cancers are hormone sensitive.

• #41 Invasive lobular breast cancer: Prognosis, treatment, and remission

  https://www.medicalnewstoday.com/articles/323284

  Diagnosing ILC can be challenging since there may be less noticeable symptoms. […] In general, if doctors diagnose and treat cancer in the early stages, survival rates tend to be higher. If cancer has advanced, for example, by spreading beyond the breast tissue, survival rates are likely to be lower. […] The 5-year survival rate for ILC is 88.6%, and the 10-year survival rate is 73.6%.

• #42 Invasive Lobular Breast Cancer: 6 Things To Know | MyBCTeam

  https://www.mybcteam.com/resources/invasive-lobular-breast-cancer-things-to-know

  Invasive lobular breast cancer technically called invasive lobular carcinoma (ILC) is the second most common type of breast cancer in the United States. Unfortunately, its not as well-researched as the most common, invasive ductal carcinoma (IDC). ILC is also harder to detect early and more likely to be diagnosed at more advanced stages. […] The symptoms of ILC and where it tends to spread […] People with IDC are more likely to have classic symptoms of breast cancer, such as a lump in the breast. On the other hand, people with ILC may notice dimpling in the breast skin or that certain areas of their breast may feel especially thick. […] By the time its finally diagnosed, the tumors may be larger and the cancer may be in a more advanced stage. […] The prognosis for ILC largely depends on the stage of your cancer. […] The five-year survival rate for ILC is nearly 100 percent if treated at an early stage, 93 percent if cancer has spread nearby, and 22 percent if cancer has spread widely in the body. […] The prognosis is worse for those with ILC that’s HER2-positive without ER or PR hormone receptors.

• #43 Lobular Breast Cancer: Here’s What You Need To Know – Ezra

  https://ezra.com/blog/lobular-breast-cancer

  Lobular breast cancer is a type of invasive breast cancer often referred to as invasive lobular carcinoma (ILC). Invasive breast cancer means the cancer cells have moved outside of the lobule of the breast. […] You most likely wont initially see symptoms of early lobular breast cancer, but breast changes can occur as the cancer grows. These changes include: Thickening (or toughening) in part of the breast, Fullness or swelling (enlargement) in the breast, Dimpling or thickening of the skin of the breast, Nipple inversion that was not previously there. […] It’s important to note that lobular breast cancer is less likely to form a distinct lump often associated with identifying breast cancer. […] If you notice any of these symptoms, it’s important to see your healthcare provider so they can do a full medical exam and schedule testing. […] As with all cancers, early detection is key to improving treatment options so you can move on to enjoying life. Since lobular breast cancer doesn’t create the classic lump many women are taught to look for, routine screening can identify cancer sooner, while it’s still in the early stages.

• #44 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer/

  Invasive lobular breast cancer may not cause any obvious changes to the breast. […] Symptoms of invasive lobular breast cancer include: A thickening of the breast tissue, A change in the shape or size of the breast, A change of skin texture such as puckering or dimpling, A lump or swelling under the arm, Changes to the nipple, Discharge from the nipple, A breast lump (although this is less common). […] You may be diagnosed with invasive lobular breast cancer during routine breast screening before you have noticed any symptoms. However, lobular breast cancer can be more difficult to see on a mammogram than other types of breast cancer.

• #45 Lobular Carcinoma: Symptoms, Causes, Treatments, and More

  https://resources.healthgrades.com/right-care/breast-cancer/lobular-carcinoma

  Lobular carcinoma does not usually cause a lump that you can feel. Instead, you may notice a thickening or hardening of an area of your breast tissue. In some cases, the condition may affect both breasts. Being aware of how your breasts normally feel can help you identify any unusual changes. […] Other symptoms you may experience with lobular carcinoma include: swelling of the breast tissue, dimpling of the skin, changes to the nipple, such as becoming inverted. […] Invasive lobular carcinoma is the second most common type of breast cancer. About 10% of breast cancer cases are invasive lobular carcinomas. […] In this type of cancer, abnormal cells grow beyond the lobule and invade surrounding breast tissues. They can also spread beyond the breast into lymph nodes and distant areas of the body.

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