Materiały źródłowe

• #1 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Invasive lobular carcinoma (ILC) is the second most common form of breast cancer, accounting for approximately 10-15% of invasive breast cancer diagnoses. […] ILC is a slow-growing cancer. However, it can be more difficult to detect and diagnose than other types of breast cancer because it tends to grow out in straight lines rather than forming a mass or lump. […] ILC is the only type of breast cancer that grows in the lobules (milk glands) of the breast. All other types grow in the milk ducts. […] The majority of women diagnosed with ILC are over the age of 55, making it more common in post-menopausal women. However, ILC can occur at any age. […] Invasive lobular carcinoma (ILC) is invasive breast cancer that begins in the lobules (milk glands) of the breast and spreads into the surrounding breast tissue.

• #2 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. […] Mammography and ultrasoundstandard breast imaging toolsare less reliable for early detection of lobular breast cancer or recurrent disease. […] Breast cancers are typically treated with a multidisciplinary approach involving surgery, radiation, and systemic therapies. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] BCRF is proud to support lobular breast cancer research and bring scientists and clinicians together to propel the field forward in hopes of finding new treatments for invasive lobular carcinoma.

• #3 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. There are some important differences in how invasive lobular is treated and behaves, and researchers are now studying ILC more closely. […] As a low-grade cancer, the prognosis for early-stage ILC is generally good. However, the disease has a higher chance of returning after 10 years than invasive ductal carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] He adds that prognostic tools such as Oncotype DX and MammaPrint are not very useful in invasive lobular carcinoma for the same reasons.

• #4 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  More than 80% of invasive lobular carcinoma is hormone receptor-positive (HR+) breast cancer. […] Invasive lobular carcinoma typically invades breast tissue by spreading out through the breast, growing in straight lines, rather than forming a tight clump or lump. […] It is important to remember that not all breast changes are breast cancer. However, all breast changes, including those listed above, should be reported to your doctor promptly. […] The severity of invasive lobular carcinoma depends on the stage at diagnosis and how far the cancer has spread. […] Because it is difficult to detect through early screening methods, invasive lobular carcinoma can grow large and spread before it is diagnosed, often leading to ILC being diagnosed at a later stage than other breast cancers. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently.

• #5 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. This activity educates the student about the etiology, epidemiology, clinical evaluation, and the importance of treatment of lobular carcinoma of the breast. […] Summarize interprofessional team strategies for improving care coordination and communication to advance the care of lobular breast cancer and improve outcomes. […] The treatment of invasive lobular carcinomas has been a topic of debate due to the potential bilaterality and multifocality that characterize these tumors. Determining the extent of invasive lobular carcinoma is very important in deciding the treatment modality. The multidisciplinary approach to the treatment includes surgery, hormonal therapy, radiation therapy, and chemotherapy.

• #6

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/invasive-lobular-carcinoma

  Invasive lobular carcinoma (ILC) is a form of breast cancer that begins in the milk-producing glands of the breast. […] Our breast cancer specialists at Aurora Breast Centers are by your side. We offer the latest ILC treatments and diagnostic tests ranging from genetic testing to new clinical trials, ensuring you receive the most comprehensive cancer care available in Wisconsin. […] Invasive lobular carcinoma starts within the milk glands (lobules) of your breast, and later invades surrounding breast tissue and possibly other parts of your body. […] ILC symptoms may include: Breast pain or discomfort, Changes in breast shape or size, Changes in the skin of the breast, Nipple discharge, Swelling of the breast or arm, Thickening or hardening of breast tissue. […] Treatment for invasive lobular carcinoma may involve a combination of surgery, radiation therapy, chemotherapy, hormone therapy and targeted therapy.

• #7 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. […] Mammography and ultrasoundstandard breast imaging toolsare less reliable for early detection of lobular breast cancer or recurrent disease. […] Breast cancers are typically treated with a multidisciplinary approach involving surgery, radiation, and systemic therapies. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] BCRF is proud to support lobular breast cancer research and bring scientists and clinicians together to propel the field forward in hopes of finding new treatments for invasive lobular carcinoma.

• #8 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  More than 80% of invasive lobular carcinoma is hormone receptor-positive (HR+) breast cancer. […] Invasive lobular carcinoma typically invades breast tissue by spreading out through the breast, growing in straight lines, rather than forming a tight clump or lump. […] It is important to remember that not all breast changes are breast cancer. However, all breast changes, including those listed above, should be reported to your doctor promptly. […] The severity of invasive lobular carcinoma depends on the stage at diagnosis and how far the cancer has spread. […] Because it is difficult to detect through early screening methods, invasive lobular carcinoma can grow large and spread before it is diagnosed, often leading to ILC being diagnosed at a later stage than other breast cancers. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently.

• #9 Invasive Lobular Carcinoma: Symptoms, Treatment, Research | BCRF

  https://www.bcrf.org/about-breast-cancer/invasive-lobular-carcinoma/

  Lobular carcinoma is treatable but has a unique biology that affects symptoms, diagnosis, and therapeutic strategies. […] The diffuse growth pattern of lobular carcinoma can make diagnosis particularly challenging. […] Mammography and ultrasoundstandard breast imaging toolsare less reliable for early detection of lobular breast cancer or recurrent disease. […] Breast cancers are typically treated with a multidisciplinary approach involving surgery, radiation, and systemic therapies. […] The majority of these cancers are hormone receptor (HR)positive, so endocrine (anti-hormone) therapies are typically administered for lobular breast cancer treatment. […] Although lobular breast cancer responds to hormone therapies, tumors can become resistant to treatment. […] The lack of clinical trials specific to lobular breast cancer continues to be a major barrier to advancing treatments for patients with this disease. […] BCRF is proud to support lobular breast cancer research and bring scientists and clinicians together to propel the field forward in hopes of finding new treatments for invasive lobular carcinoma.

• #10 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  A breast MRI, however, will show all of the tentacles in most cases. […] After invasive lobular carcinoma is confirmed through imaging tests and a biopsy, lab tests will be performed to collect more information about the cancer. […] Most invasive lobular carcinoma (ILC) is ER+, PR+, and HER2-. It is also known for being a slower growing breast cancer. […] Like other types of breast cancer, the regimen chosen to treat invasive lobular carcinoma will vary based on the characteristics of the cancerous cells, the stage and grade of the cancer, the size of the cancerous cells, and the overall health of the patient. […] Surgery is often used to treat invasive lobular carcinoma. […] Radiation uses high-energy rays to destroy cancer cells and may be used after breast surgery to destroy any ILC left behind and reduce the chance of the cancer coming back.

• #11 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because of this, lobular breast cancer can be treated with endocrine therapy. […] To help identify lobular breast cancer early, Mouabbi urges patients who fall into these categories be monitored with an MRI rather than an ultrasound. […] Most women diagnosed with ILC get surgery to remove the growth. […] Patients with these cancers receive hormone therapy, which blocks the interaction of estrogen with the cancer cells estrogen receptors or lowers the bodys natural estrogen production. […] Targeted therapy drugs are designed to stop or slow the growth or spread of cancer. […] Radiation therapy uses powerful, focused beams of energy to kill cancer cells. […] The team at the Nellie B. Connally Breast Center includes doctors who specialize in treating ILC. They work together to develop treatment plans tailored to this specific cancer and to each individual patient. These treatments are designed to eliminate the cancer and maximize your quality of life.

• #12

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/invasive-lobular-carcinoma

  If you notice any persistent changes in your breast health or experience any of the symptoms mentioned above, schedule an appointment with your doctor for further evaluation. […] Invasive lobular carcinoma may be diagnosed through a combination of methods, including an examination, imaging studies and tissue biopsy. […] The diagnosing process will start with a physical exam of the breasts and surrounding lymph nodes to check for lumps, thickening or changes in appearance. […] If imaging studies detect abnormalities in the breast, a biopsy is necessary to confirm or deny the diagnosis of invasive lobular carcinoma. […] Upon confirmation of a diagnosis of ILC, further tests may be ordered by your doctor to evaluate the stage of your cancer and whether it has spread to other parts of your body.

• #13 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer/

  Invasive lobular breast cancer is a type of cancer that affects the cells of the lobules (milk-producing glands) of the breast. […] Invasive lobular breast cancer is diagnosed using a range of tests, which may include: A mammogram, An ultrasound scan, A core biopsy of the breast and sometimes lymph nodes, A fine needle aspiration (FNA) of the breast and sometimes lymph nodes, A breast MRI scan. […] The first treatment for invasive lobular breast cancer is usually surgery. […] You may have Breast-conserving surgery, A mastectomy. […] After surgery you will usually need other treatments. These are called adjuvant (additional) treatments and can include: Chemotherapy, Radiotherapy, Hormone (endocrine) therapy, Targeted (biological) therapy, Bisphosphonates. […] You’ll continue to be monitored after your hospital-based treatments (such as surgery, chemotherapy or radiotherapy) finish. This is known as follow-up.

• #14 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  More than 80% of invasive lobular carcinoma is hormone receptor-positive (HR+) breast cancer. […] Invasive lobular carcinoma typically invades breast tissue by spreading out through the breast, growing in straight lines, rather than forming a tight clump or lump. […] It is important to remember that not all breast changes are breast cancer. However, all breast changes, including those listed above, should be reported to your doctor promptly. […] The severity of invasive lobular carcinoma depends on the stage at diagnosis and how far the cancer has spread. […] Because it is difficult to detect through early screening methods, invasive lobular carcinoma can grow large and spread before it is diagnosed, often leading to ILC being diagnosed at a later stage than other breast cancers. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently.

• #15 Invasive Lobular Carcinoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/ilc.html

  Invasive lobular carcinoma (ILC), also known as lobular breast cancer, accounts for 15% of all new breast cancer diagnoses. ILC tumors do not usually form in lumps and are hard to image with screening tests or to feel in self-exams. The hallmark of lobular breast cancer is the lack of the protein E-cadherin, which helps cancer cells adhere to each other. Because E-cadherin is absent in ILC, ILC tumor cells typically grow diffusely in unconnected lines, throughout the breast without distorting the surrounding structures or forming a lump. This makes them extremely hard to detect on mammograms and ultrasound, especially in women with dense breast tissue, or to visualize elsewhere in the body if metastasized. It also makes even large ILC tumors hard to feel. Symptoms of ILC tumors can range from none to changes in the appearance of the nipple or breast, such as dimpling, hardening of the breast, swelling, or pain. On self-examination, ILC often does not feel like a lump but can sometimes be felt as a firmness or mass.

• #16

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/invasive-lobular-carcinoma

  Invasive lobular carcinoma (ILC) is a form of breast cancer that begins in the milk-producing glands of the breast. […] Our breast cancer specialists at Aurora Breast Centers are by your side. We offer the latest ILC treatments and diagnostic tests ranging from genetic testing to new clinical trials, ensuring you receive the most comprehensive cancer care available in Wisconsin. […] Invasive lobular carcinoma starts within the milk glands (lobules) of your breast, and later invades surrounding breast tissue and possibly other parts of your body. […] ILC symptoms may include: Breast pain or discomfort, Changes in breast shape or size, Changes in the skin of the breast, Nipple discharge, Swelling of the breast or arm, Thickening or hardening of breast tissue. […] Treatment for invasive lobular carcinoma may involve a combination of surgery, radiation therapy, chemotherapy, hormone therapy and targeted therapy.

• #17 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  More than 80% of invasive lobular carcinoma is hormone receptor-positive (HR+) breast cancer. […] Invasive lobular carcinoma typically invades breast tissue by spreading out through the breast, growing in straight lines, rather than forming a tight clump or lump. […] It is important to remember that not all breast changes are breast cancer. However, all breast changes, including those listed above, should be reported to your doctor promptly. […] The severity of invasive lobular carcinoma depends on the stage at diagnosis and how far the cancer has spread. […] Because it is difficult to detect through early screening methods, invasive lobular carcinoma can grow large and spread before it is diagnosed, often leading to ILC being diagnosed at a later stage than other breast cancers. […] Detecting and diagnosing invasive lobular carcinoma can be more difficult than other forms of breast cancer because the cancerous cells of ILC form and grow differently.

• #18 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. This activity educates the student about the etiology, epidemiology, clinical evaluation, and the importance of treatment of lobular carcinoma of the breast. […] Summarize interprofessional team strategies for improving care coordination and communication to advance the care of lobular breast cancer and improve outcomes. […] The treatment of invasive lobular carcinomas has been a topic of debate due to the potential bilaterality and multifocality that characterize these tumors. Determining the extent of invasive lobular carcinoma is very important in deciding the treatment modality. The multidisciplinary approach to the treatment includes surgery, hormonal therapy, radiation therapy, and chemotherapy.

• #19 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Adjuvant hormone therapy is also indicated, given the high percentage of cases that are positive for ER and PR. […] Management of invasive lobular breast carcinoma needs an interprofessional approach involving a team that consists of a surgical oncologist, a medical oncologist, a radiation oncologist, a pathologist, a radiologist, and an oncology nurse, all collaborating through disciplines to realize optimal patient results.

• #20 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Your treatment plan will depend on many factors. Your healthcare team considers the stage of the cancer and how quickly it’s growing. Your care team also considers your overall health and what you prefer. […] A lumpectomy involves removing the cancer and some of the healthy tissue that surrounds it. […] During a total mastectomy, the surgeon removes the breast tissue, nipple, areola and skin. […] Surgery for invasive lobular carcinoma typically involves a procedure to remove the breast cancer and a procedure to remove some nearby lymph nodes. […] A lumpectomy is surgery to remove the invasive lobular carcinoma and some of the healthy tissue around it. […] A mastectomy is surgery to remove all breast tissue from a breast. […] A sentinel node biopsy is an operation to take out some lymph nodes for testing.

• #21 Lobular Breast Cancer Prognosis and Survival Rates

  https://www.healthline.com/health/breast-cancer/lobular-breast-cancer-prognosis-survival

  Lobular breast cancer starts in the milk-producing lobules and can spread through metastasis. The prognosis depends on factors such as cancer grade and stage and long-term care plans. […] ILC can be hard to diagnose because it spreads in a unique pattern that may not show up on imaging tests. However, its a slow-growing cancer, which gives doctors time to plan treatment. […] Your options include lumpectomy or mastectomy, depending on the stage of cancer, as well as hormonal therapy and chemotherapy. […] Radiation may be necessary after a lumpectomy. Your doctor will create a personalized care plan depending on your health and the latest technologies available. […] If you’ve been treated for ILC, it’s especially important to schedule a physical exam and a mammogram every year after your treatment. The first one should take place 6 months after surgery or radiation therapy is complete.

• #22 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Your treatment plan will depend on many factors. Your healthcare team considers the stage of the cancer and how quickly it’s growing. Your care team also considers your overall health and what you prefer. […] A lumpectomy involves removing the cancer and some of the healthy tissue that surrounds it. […] During a total mastectomy, the surgeon removes the breast tissue, nipple, areola and skin. […] Surgery for invasive lobular carcinoma typically involves a procedure to remove the breast cancer and a procedure to remove some nearby lymph nodes. […] A lumpectomy is surgery to remove the invasive lobular carcinoma and some of the healthy tissue around it. […] A mastectomy is surgery to remove all breast tissue from a breast. […] A sentinel node biopsy is an operation to take out some lymph nodes for testing.

• #23 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Axillary lymph node dissection is an operation to remove many lymph nodes from the armpit. […] Some people who have invasive lobular carcinoma in one breast may choose to have their other breast removed, even if it doesn’t have cancer. […] Complications of breast cancer surgery depend on the procedures you choose. All operations have a risk of pain, bleeding and infection. […] Hormone therapy, also called endocrine therapy, uses medicines to block certain hormones in the body. It’s a treatment for breast cancers that are sensitive to the hormones estrogen and progesterone. […] Most invasive lobular carcinomas are sensitive to hormones, so they are likely to respond to this treatment. […] Radiation therapy treats cancer with powerful energy beams. […] The radiation used to treat invasive lobular carcinoma and other types of breast cancer is often external beam radiation.

• #24 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  Invasive lobular breast cancer is the second most common type of breast cancer. It is also known as invasive lobular carcinoma. […] The treatment for invasive lobular breast cancer is the same as for the more common type of breast cancer. This is known as invasive breast cancer No Special Type (NST). […] Your doctor and breast cancer nurse will talk to you about your individual treatment plan. […] You usually have either breast conserving surgery or a mastectomy. […] Breast conserving surgery removes the area of cancer and a surrounding area of healthy tissue. This operation is also called a wide local excision or lumpectomy. […] You might have chemotherapy or hormone therapy before surgery. This is known as neo adjuvant treatment. […] After the surgery, you might have one or more of the following treatments: radiotherapy, chemotherapy, hormone therapy, targeted cancer drug therapy, drugs that help prevent or slow down bone thinning (osteoporosis) or bone damage.

• #25 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Axillary lymph node dissection is an operation to remove many lymph nodes from the armpit. […] Some people who have invasive lobular carcinoma in one breast may choose to have their other breast removed, even if it doesn’t have cancer. […] Complications of breast cancer surgery depend on the procedures you choose. All operations have a risk of pain, bleeding and infection. […] Hormone therapy, also called endocrine therapy, uses medicines to block certain hormones in the body. It’s a treatment for breast cancers that are sensitive to the hormones estrogen and progesterone. […] Most invasive lobular carcinomas are sensitive to hormones, so they are likely to respond to this treatment. […] Radiation therapy treats cancer with powerful energy beams. […] The radiation used to treat invasive lobular carcinoma and other types of breast cancer is often external beam radiation.

• #26 Invasive Lobular Carcinoma (ILC) | Cancer Care and Oncology | Bon Secours

  https://www.bonsecours.com/health-care-services/cancer-care-oncology/conditions/invasive-lobular-carcinoma

  Invasive lobular carcinoma is the second most common type of cancer. […] Treatment for ILC may include surgery, chemotherapy, hormone therapy, targeted therapy and/or radiation therapy. […] Depending on your personal health history, the extent of your invasive lobular carcinoma and other factors, your oncologist may recommend one or more of the following treatment options: […] Surgery in most cases, your doctor will recommend a surgical procedure to remove the cancerous area. […] Chemotherapy you may need to undergo chemotherapy to destroy any cancerous cells that couldn’t be removed surgically. […] Hormone therapy if you have hormone receptor-positive breast cancer, your oncologist may recommend you undergo hormone therapy for estrogen and progesterone. […] Radiation therapy this treatment uses high-powered energy beams to destroy cancerous cells. […] Targeted therapy this treatment focuses on the molecular changes that make cancer cells grow and spread.

• #27 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Axillary lymph node dissection is an operation to remove many lymph nodes from the armpit. […] Some people who have invasive lobular carcinoma in one breast may choose to have their other breast removed, even if it doesn’t have cancer. […] Complications of breast cancer surgery depend on the procedures you choose. All operations have a risk of pain, bleeding and infection. […] Hormone therapy, also called endocrine therapy, uses medicines to block certain hormones in the body. It’s a treatment for breast cancers that are sensitive to the hormones estrogen and progesterone. […] Most invasive lobular carcinomas are sensitive to hormones, so they are likely to respond to this treatment. […] Radiation therapy treats cancer with powerful energy beams. […] The radiation used to treat invasive lobular carcinoma and other types of breast cancer is often external beam radiation.

• #28 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Chemotherapy uses a combination of oral or intravenous (IV) drugs to destroy cancer cells or slow their growth. […] Hormonal therapy uses drugs to block or lower the levels of hormones, such as estrogen and progesterone, in the body, which can help slow or stop the growth of some breast cancers, including invasive lobular carcinoma. […] When detected and treated in the early stages, the prognosis for invasive lobular carcinoma is very good. […] Survival rates for invasive lobular carcinoma are grouped into three stages: localized, regional, and distant. […] Invasive lobular carcinoma recurrence is when the cancer is later found to still be present in the body somewhere after initial successful treatment. […] A recurrence of invasive lobular carcinoma cannot be prevented, but there are ways to lower the risk of recurrence, including: Staying in contact with your oncologist for follow-up appointments, Taking hormonal therapy exactly as prescribed (if cancer was hormone receptor-positive), Continuing early detection (mammograms and breast self-exams) on any remaining breast tissue, as recommended by your doctor.

• #29 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Because of this, lobular breast cancer can be treated with endocrine therapy. […] To help identify lobular breast cancer early, Mouabbi urges patients who fall into these categories be monitored with an MRI rather than an ultrasound. […] Most women diagnosed with ILC get surgery to remove the growth. […] Patients with these cancers receive hormone therapy, which blocks the interaction of estrogen with the cancer cells estrogen receptors or lowers the bodys natural estrogen production. […] Targeted therapy drugs are designed to stop or slow the growth or spread of cancer. […] Radiation therapy uses powerful, focused beams of energy to kill cancer cells. […] The team at the Nellie B. Connally Breast Center includes doctors who specialize in treating ILC. They work together to develop treatment plans tailored to this specific cancer and to each individual patient. These treatments are designed to eliminate the cancer and maximize your quality of life.

• #30 Invasive Lobular Cancer (ILC) Melbourne, VIC | Radiotherapy Melbourne, VIC

  https://www.melbournebreastcancersurgery.com.au/breast-cancer/invasive-lobular-cancer-ilc.html

  Most commonly, the anti-estrogen therapy tamoxifen is recommended for premenopausal women while an aromatase inhibitor such as letrozole or anastrozole is given to postmenopausal women. […] In most cases of breast cancer, breast-conserving surgery by wide local excision is performed to remove the tumour with a margin of the surrounding normal tissue. However, in ILC, there is evidence that 17-65% of patients have to undergo a second surgical intervention. […] Consequently, patients with ILC are more likely to undergo breast removal by mastectomy. […] The innately infiltrative growth pattern of ILC and difficult preoperative assessment of extent of disease have historically led surgeons to question the feasibility of breast conserving therapy (BCT) in ILC. […] Neoadjuvant chemotherapy (NAC) is aimed at improving rates of breast-conserving surgery. However, consensus has emerged that ILC tends to respond poorly to chemotherapy, leading to lower disease-free and overall survival following neoadjuvant chemotherapy compared with IDC.

• #31 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  ILC cells often have receptors for the hormones estrogen and progesterone. Receptors are special proteins that help the hormones tell cells to grow and divide. Hormone therapy drugs for ILC lower the amount of estrogen in your body or keep it from telling cancer cells to grow. […] Hormone therapy can also reduce the risk of your cancer returning. Your doctor may keep you on hormone therapy for 5-10 years or even longer to protect against recurrence, says Thompson. […] Cancer affects everyone differently. Your outlook may depend on things such as how early youre diagnosed and how well your body responds to treatment. […] In general, about 91% of all women with breast cancer live at least five years after diagnosis. While there isnt much information about specific types of breast cancer, these survival rates are tracked by stage at diagnosis or how far the cancer has spread: Localized (cancer hasnt spread outside the breast): More than 99% live at least five years. Regional (cancer has spread to lymph nodes near the breast): 87% live at least five years. Distant (cancer has spread farther in the body): 32% live at least five years.

• #32 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Axillary lymph node dissection is an operation to remove many lymph nodes from the armpit. […] Some people who have invasive lobular carcinoma in one breast may choose to have their other breast removed, even if it doesn’t have cancer. […] Complications of breast cancer surgery depend on the procedures you choose. All operations have a risk of pain, bleeding and infection. […] Hormone therapy, also called endocrine therapy, uses medicines to block certain hormones in the body. It’s a treatment for breast cancers that are sensitive to the hormones estrogen and progesterone. […] Most invasive lobular carcinomas are sensitive to hormones, so they are likely to respond to this treatment. […] Radiation therapy treats cancer with powerful energy beams. […] The radiation used to treat invasive lobular carcinoma and other types of breast cancer is often external beam radiation.

• #33 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  A breast MRI, however, will show all of the tentacles in most cases. […] After invasive lobular carcinoma is confirmed through imaging tests and a biopsy, lab tests will be performed to collect more information about the cancer. […] Most invasive lobular carcinoma (ILC) is ER+, PR+, and HER2-. It is also known for being a slower growing breast cancer. […] Like other types of breast cancer, the regimen chosen to treat invasive lobular carcinoma will vary based on the characteristics of the cancerous cells, the stage and grade of the cancer, the size of the cancerous cells, and the overall health of the patient. […] Surgery is often used to treat invasive lobular carcinoma. […] Radiation uses high-energy rays to destroy cancer cells and may be used after breast surgery to destroy any ILC left behind and reduce the chance of the cancer coming back.

• #34 Invasive Lobular Carcinoma (ILC)

  https://www.cancercenter.com/cancer-types/breast-cancer/types/common-breast-cancer-types/invasive-lobular-carcinoma

  Invasive lobular carcinoma (ILC) is a type of invasive breast cancer, meaning the cancer has spread into surrounding breast tissue. […] ILC is often difficult to detect on a mammogram. […] The treatment for ILC can vary, depending on the type of cancer, the patients preferences and preexisting health conditions. […] Surgery is a frequently used treatment for ILC. […] Radiation therapy is a treatment that uses high-energy X-rays to precisely target and kill cancer cells. […] For cancers that are hormone positive, hormone therapy can be used as a treatment option, sometimes given before or after surgery. […] Chemotherapy uses medication to kill cancer cells. […] Treatment options or any treatment side effects should be discussed with a patients medical team.

• #35 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Chemotherapy for invasive lobular carcinoma and other types of breast cancer is often used after surgery. […] Sometimes chemotherapy is given before surgery for invasive lobular carcinoma and other types of breast cancer. […] Targeted therapy uses medicines that attack specific chemicals in the cancer cells. […] Most invasive lobular carcinomas don’t make extra HER2, so they are unlikely to respond to treatments that target HER2.

• #36 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Chemotherapy uses a combination of oral or intravenous (IV) drugs to destroy cancer cells or slow their growth. […] Hormonal therapy uses drugs to block or lower the levels of hormones, such as estrogen and progesterone, in the body, which can help slow or stop the growth of some breast cancers, including invasive lobular carcinoma. […] When detected and treated in the early stages, the prognosis for invasive lobular carcinoma is very good. […] Survival rates for invasive lobular carcinoma are grouped into three stages: localized, regional, and distant. […] Invasive lobular carcinoma recurrence is when the cancer is later found to still be present in the body somewhere after initial successful treatment. […] A recurrence of invasive lobular carcinoma cannot be prevented, but there are ways to lower the risk of recurrence, including: Staying in contact with your oncologist for follow-up appointments, Taking hormonal therapy exactly as prescribed (if cancer was hormone receptor-positive), Continuing early detection (mammograms and breast self-exams) on any remaining breast tissue, as recommended by your doctor.

• #37 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. There are some important differences in how invasive lobular is treated and behaves, and researchers are now studying ILC more closely. […] As a low-grade cancer, the prognosis for early-stage ILC is generally good. However, the disease has a higher chance of returning after 10 years than invasive ductal carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] He adds that prognostic tools such as Oncotype DX and MammaPrint are not very useful in invasive lobular carcinoma for the same reasons.

• #38 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Invasive lobular carcinoma is different from ductal carcinoma. […] Invasive lobular carcinoma isn’t rare. […] Because of the number of diagnoses each year, Mouabbi says it’s important to conduct studies devoted to the subtype to improve care. […] Standard of care treatment not tailored to invasive lobular carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isn’t much clinical benefit. […] Endocrine therapy is effective in treating invasive lobular carcinoma. […] To define more personalized approaches, Mouabbi says it’s critical to conduct clinical trials specific to lobular breast cancer.

• #39 Chemotherapy Benefits in Invasive Lobular Carcinoma

  https://www.rockymountaincancercenters.com/referring-providers-blog/chemotherapy-benefits-in-invasive-lobular-carcinoma

  While treatment of ILC with chemotherapy neoadjuvant therapy is less responsive, there are benefits of using chemotherapy in ILC, such as relieving tumor burden to allow breast-conserving surgery to be performed and improving quality of life. Adjuvant treatments after surgery with chemotherapy are often not performed since the disease is slow-growing and usually responds positively to hormone treatment alone. Despite the report of chemotherapy having less responsiveness in ILC, a subset of ILC patients at high risk of recurring and progressing disease may benefit from the use of chemotherapy. […] Our ultimate goal is to improve survival outcomes in ILC patients with a high oncotype recurrence score, said Dr. Solipuram. The use of adjuvant chemotherapy seems to provide an overall survival benefit as compared to not using chemotherapy in patients with a high-recurrence subtype.

• #40 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Treatment for invasive lobular carcinoma often starts with surgery to remove the cancer. Most people with breast cancer will have other treatments after surgery, such as radiation, chemotherapy and hormone therapy. Some people may have chemotherapy or hormone therapy before surgery. These medicines can help shrink the cancer and make it easier to remove. […] Invasive lobular carcinoma treatment is very similar to the treatment for other types of breast cancer. Some things that might be different with this type of cancer include: […] Most invasive lobular carcinomas are sensitive to hormones. Breast cancers that are sensitive to hormones are likely to respond to hormone-blocking treatments. This kind of treatment is called hormone therapy or endocrine therapy. […] Most invasive lobular carcinomas don’t make extra HER2. HER2 is a protein that some healthy breast cells make. Some breast cancer cells develop changes that cause them to make a lot of extra HER2. Treatments can target the cells that are making extra HER2. Invasive lobular carcinomas are less likely to make extra HER2, so they’re less likely to respond to this treatment.

• #41 Invasive lobular carcinoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/invasive-lobular-carcinoma/diagnosis-treatment/drc-20373979

  Chemotherapy for invasive lobular carcinoma and other types of breast cancer is often used after surgery. […] Sometimes chemotherapy is given before surgery for invasive lobular carcinoma and other types of breast cancer. […] Targeted therapy uses medicines that attack specific chemicals in the cancer cells. […] Most invasive lobular carcinomas don’t make extra HER2, so they are unlikely to respond to treatments that target HER2.

• #42 Get Lobular Breast Cancer Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/lobular-breast-cancer-treatment

  You may also choose to have breast reconstruction. […] Our breast and plastic surgeons work closely together, making it possible for you to have a mastectomy and reconstruction at the same time. […] Our oncology nurses are here to guide you and your family throughout your breast cancer treatment and recovery. […] This includes helping you manage any treatment side effects. […] Cleveland Clinic offers many additional services and support to get you through this challenging time. […] While lobular breast cancer usually grows slowly, it can still spread if left untreated. […] So, the faster you move toward confirming you have it and starting treatment the better chance you have for good results.

• #43 Breast Cancer | WVU Cancer Institute

  https://wvumedicine.org/cancer/cancer-services/breast-cancer/

  Invasive lobular carcinoma is a form of breast cancer that starts in the glands (lobules) that produce breast milk and spreads to nearby tissue. It may also spread to other parts of the body. […] Our compassionate team of breast cancer experts designs a treatment plan that addresses your specific needs. We consider many factors when planning your treatment, including the cancer type, the location and size of the tumor, your age, and whether the cancer is new, recurrent, or metastasized, as well as your personal goals for your cancer care. We often treat breast cancers using surgery, radiation therapy, and systemic therapy that may include chemotherapy. We treat some breast cancers using intraoperative radiation therapy. […] We offer the latest treatments, including medical oncology, which includes chemotherapy, immunotherapy, targeted therapy, and anti-hormone therapy. Our doctors use the latest in anti-cancer medicine to destroy cancer cells.

• #44 Get Lobular Breast Cancer Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/lobular-breast-cancer-treatment

  You may also choose to have breast reconstruction. […] Our breast and plastic surgeons work closely together, making it possible for you to have a mastectomy and reconstruction at the same time. […] Our oncology nurses are here to guide you and your family throughout your breast cancer treatment and recovery. […] This includes helping you manage any treatment side effects. […] Cleveland Clinic offers many additional services and support to get you through this challenging time. […] While lobular breast cancer usually grows slowly, it can still spread if left untreated. […] So, the faster you move toward confirming you have it and starting treatment the better chance you have for good results.

• #45 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Contact your cancer care team if you have: Surgical wound infection symptoms like a fever (greater than 101 degrees Fahrenheit or 38.4 degrees Celsius) or thick, cloudy discharge from the incision (cut), Cancer treatment side effects that are stronger than you expected, like vomiting that you can’t control, Pain that prescription pain medication doesn’t ease. […] A lobular breast cancer diagnosis can be scary. At Cleveland Clinic, we offer expert diagnosis and personalized treatment for lobular breast cancer.

• #46 Get Lobular Breast Cancer Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/lobular-breast-cancer-treatment

  You may also choose to have breast reconstruction. […] Our breast and plastic surgeons work closely together, making it possible for you to have a mastectomy and reconstruction at the same time. […] Our oncology nurses are here to guide you and your family throughout your breast cancer treatment and recovery. […] This includes helping you manage any treatment side effects. […] Cleveland Clinic offers many additional services and support to get you through this challenging time. […] While lobular breast cancer usually grows slowly, it can still spread if left untreated. […] So, the faster you move toward confirming you have it and starting treatment the better chance you have for good results.

• #47 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Contact your cancer care team if you have: Surgical wound infection symptoms like a fever (greater than 101 degrees Fahrenheit or 38.4 degrees Celsius) or thick, cloudy discharge from the incision (cut), Cancer treatment side effects that are stronger than you expected, like vomiting that you can’t control, Pain that prescription pain medication doesn’t ease. […] A lobular breast cancer diagnosis can be scary. At Cleveland Clinic, we offer expert diagnosis and personalized treatment for lobular breast cancer.

• #48 Lobular Breast Cancer Program | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-conditions/breast-cancer/lobular-breast-cancer-program

  MSK’s lobular cancer experts may recommend genomic or genetic tests. […] We diagnose and see more people with lobular cancer than most centers in the country. […] MSK researchers are leading research studies, also known as clinical trials. […] Some standard treatments do not work as well for invasive lobular breast cancer. […] We have ways to help manage nausea during chemotherapy. […] We also run support groups and programs if you want to talk with other people going through a similar experience.

• #49 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Chemotherapy uses a combination of oral or intravenous (IV) drugs to destroy cancer cells or slow their growth. […] Hormonal therapy uses drugs to block or lower the levels of hormones, such as estrogen and progesterone, in the body, which can help slow or stop the growth of some breast cancers, including invasive lobular carcinoma. […] When detected and treated in the early stages, the prognosis for invasive lobular carcinoma is very good. […] Survival rates for invasive lobular carcinoma are grouped into three stages: localized, regional, and distant. […] Invasive lobular carcinoma recurrence is when the cancer is later found to still be present in the body somewhere after initial successful treatment. […] A recurrence of invasive lobular carcinoma cannot be prevented, but there are ways to lower the risk of recurrence, including: Staying in contact with your oncologist for follow-up appointments, Taking hormonal therapy exactly as prescribed (if cancer was hormone receptor-positive), Continuing early detection (mammograms and breast self-exams) on any remaining breast tissue, as recommended by your doctor.

• #50 Invasive lobular breast cancer | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/invasive-lobular-breast-cancer

  If you’re having breast-conserving surgery, your specialist will let you know whether you need a breast MRI before the surgery. […] However, a breast MRI does not always give an accurate estimate of the size of invasive lobular breast cancer. […] After surgery you will usually need other treatments. These are called adjuvant (additional) treatments and can include: Chemotherapy, Radiotherapy, Hormone (endocrine) therapy, Targeted (biological) therapy, Bisphosphonates. […] You’ll continue to be monitored after your hospital-based treatments (such as surgery, chemotherapy or radiotherapy) finish. This is known as follow-up. […] If you have any concerns, speak with your GP or breast care nurse.

• #51 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  After treatment you usually have regular check ups. At the check ups your doctor or a breast care nurse will examine you and ask about your general health. […] UK guidelines say that everyone who has had treatment for early breast cancer should have a copy of a written care plan. The care plan has information about tests you will have, and signs and symptoms to look out for. It will also include contact details for specialist staff, such as your breast care nurse. […] Coping with invasive lobular breast cancer can be difficult. There is help and support available to you and your family.

• #52 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  After treatment you usually have regular check ups. At the check ups your doctor or a breast care nurse will examine you and ask about your general health. […] UK guidelines say that everyone who has had treatment for early breast cancer should have a copy of a written care plan. The care plan has information about tests you will have, and signs and symptoms to look out for. It will also include contact details for specialist staff, such as your breast care nurse. […] Coping with invasive lobular breast cancer can be difficult. There is help and support available to you and your family.

• #53 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. There are some important differences in how invasive lobular is treated and behaves, and researchers are now studying ILC more closely. […] As a low-grade cancer, the prognosis for early-stage ILC is generally good. However, the disease has a higher chance of returning after 10 years than invasive ductal carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] He adds that prognostic tools such as Oncotype DX and MammaPrint are not very useful in invasive lobular carcinoma for the same reasons.

• #54 Dr Mukhtar on Recurrence Risk in Invasive Lobular Carcinoma

  https://www.onclive.com/view/dr-mukhtar-on-recurrence-risk-in-invasive-lobular-carcinoma

  Rita Mukhtar, MD, discusses the risk of disease recurrence in patients with invasive lobular carcinoma. […] Due to the lower sensitivity of screening tools like mammography, patients with invasive lobular carcinoma are often diagnosed at more advanced stages of disease, which inherently increases the risk of recurrence, Mukhtar begins. […] In the initial years following diagnosis, patients with invasive lobular carcinoma generally experience favorable outcomes, Mukhtar explains, noting that these patients could have lower recurrence rates compared with those with invasive ductal carcinoma. […] The risk of late recurrence for a patient with invasive lobular carcinoma is higher than a patient within the same subtype of breast cancer who had invasive ductal carcinoma, she says. […] The higher rate of late disease recurrence observed in this patient population underscores the need for ongoing vigilance and long-term follow-up to support patients diagnosed with invasive lobular carcinoma, Mukhtar continues. […] Although many patients diagnosed with early-stage invasive lobular carcinoma can have a good prognosis following initial treatment, the cumulative risk of late recurrence necessitates sustained monitoring and potential interventions to mitigate this risk over time, she concludes.

• #55 Invasive Lobular Carcinoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21180-lobular-breast-cancer

  Contact your cancer care team if you have: Surgical wound infection symptoms like a fever (greater than 101 degrees Fahrenheit or 38.4 degrees Celsius) or thick, cloudy discharge from the incision (cut), Cancer treatment side effects that are stronger than you expected, like vomiting that you can’t control, Pain that prescription pain medication doesn’t ease. […] A lobular breast cancer diagnosis can be scary. At Cleveland Clinic, we offer expert diagnosis and personalized treatment for lobular breast cancer.

• #56 Invasive lobular breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/invasive-lobular-breast-cancer

  After treatment you usually have regular check ups. At the check ups your doctor or a breast care nurse will examine you and ask about your general health. […] UK guidelines say that everyone who has had treatment for early breast cancer should have a copy of a written care plan. The care plan has information about tests you will have, and signs and symptoms to look out for. It will also include contact details for specialist staff, such as your breast care nurse. […] Coping with invasive lobular breast cancer can be difficult. There is help and support available to you and your family.

• #57 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  In summary, we have gathered information from an international community of physicians, researchers, and patients/advocates that we expect will lay the foundation for a community-informed collaborative research agenda, with the goal of improving management and personalizing treatment for patients with ILC. […] The majority of physicians indicated that there either was no data, that they did not know, or that they were unsure if there were clinical trials and outcome data supporting unique treatments for ILC. Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians, for a number of reasons outlined in Supplementary Text File 2. […] Most physicians (71%) did not mention that ILC can metastasize to unique places and did not discuss what symptoms, including unusual symptoms, of recurrence the patients should report in the future (78%). […] Overall, while there is growing interest in the study and understanding of ILC, there are clear gaps in understanding and presentation of the disease to patients. […] While very few clinical trials have been directed specifically at ILC, most physicians expressed an interest in such trials.

• #58 Lobular Breast Cancer Program | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-conditions/breast-cancer/lobular-breast-cancer-program

  MSK’s lobular cancer experts may recommend genomic or genetic tests. […] We diagnose and see more people with lobular cancer than most centers in the country. […] MSK researchers are leading research studies, also known as clinical trials. […] Some standard treatments do not work as well for invasive lobular breast cancer. […] We have ways to help manage nausea during chemotherapy. […] We also run support groups and programs if you want to talk with other people going through a similar experience.

• #59 Invasive Lobular Carcinoma: Diagnosis, Treatment, & Prognosis

  https://www.nationalbreastcancer.org/invasive-lobular-carcinoma/

  Chemotherapy uses a combination of oral or intravenous (IV) drugs to destroy cancer cells or slow their growth. […] Hormonal therapy uses drugs to block or lower the levels of hormones, such as estrogen and progesterone, in the body, which can help slow or stop the growth of some breast cancers, including invasive lobular carcinoma. […] When detected and treated in the early stages, the prognosis for invasive lobular carcinoma is very good. […] Survival rates for invasive lobular carcinoma are grouped into three stages: localized, regional, and distant. […] Invasive lobular carcinoma recurrence is when the cancer is later found to still be present in the body somewhere after initial successful treatment. […] A recurrence of invasive lobular carcinoma cannot be prevented, but there are ways to lower the risk of recurrence, including: Staying in contact with your oncologist for follow-up appointments, Taking hormonal therapy exactly as prescribed (if cancer was hormone receptor-positive), Continuing early detection (mammograms and breast self-exams) on any remaining breast tissue, as recommended by your doctor.

• #60

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/invasive-lobular-carcinoma

  Your care team at Aurora Health Care will use a collaborative approach to provide the best treatment possible. Supportive care services such as counseling, nutrition therapy, palliative care and physical therapy may also be offered to help you manage the physical and emotional challenges of cancer treatment.

• #61 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  In summary, we have gathered information from an international community of physicians, researchers, and patients/advocates that we expect will lay the foundation for a community-informed collaborative research agenda, with the goal of improving management and personalizing treatment for patients with ILC. […] The majority of physicians indicated that there either was no data, that they did not know, or that they were unsure if there were clinical trials and outcome data supporting unique treatments for ILC. Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians, for a number of reasons outlined in Supplementary Text File 2. […] Most physicians (71%) did not mention that ILC can metastasize to unique places and did not discuss what symptoms, including unusual symptoms, of recurrence the patients should report in the future (78%). […] Overall, while there is growing interest in the study and understanding of ILC, there are clear gaps in understanding and presentation of the disease to patients. […] While very few clinical trials have been directed specifically at ILC, most physicians expressed an interest in such trials.

• #62 Invasive Lobular Carcinoma | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/breast-cancer/invasive-lobular-carcinoma.html

  Invasive lobular carcinoma (ILC) is a rare type of breast cancer that grows in the lobes of the breast, where milk is produced. […] Because most breast cancer are ductal, breast cancer research and treatment plans historically have not distinguished between the two diseases. There are some important differences in how invasive lobular is treated and behaves, and researchers are now studying ILC more closely. […] As a low-grade cancer, the prognosis for early-stage ILC is generally good. However, the disease has a higher chance of returning after 10 years than invasive ductal carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isnt much clinical benefit. […] He adds that prognostic tools such as Oncotype DX and MammaPrint are not very useful in invasive lobular carcinoma for the same reasons.

• #63 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  ILC cells often have receptors for the hormones estrogen and progesterone. Receptors are special proteins that help the hormones tell cells to grow and divide. Hormone therapy drugs for ILC lower the amount of estrogen in your body or keep it from telling cancer cells to grow. […] Hormone therapy can also reduce the risk of your cancer returning. Your doctor may keep you on hormone therapy for 5-10 years or even longer to protect against recurrence, says Thompson. […] Cancer affects everyone differently. Your outlook may depend on things such as how early youre diagnosed and how well your body responds to treatment. […] In general, about 91% of all women with breast cancer live at least five years after diagnosis. While there isnt much information about specific types of breast cancer, these survival rates are tracked by stage at diagnosis or how far the cancer has spread: Localized (cancer hasnt spread outside the breast): More than 99% live at least five years. Regional (cancer has spread to lymph nodes near the breast): 87% live at least five years. Distant (cancer has spread farther in the body): 32% live at least five years.

• #64 Invasive Lobular Carcinoma: Causes, Symptoms, Diagnosis & Risk

  https://www.webmd.com/breast-cancer/lobular-carcinoma-invasive-and-in-situ

  ILC cells often have receptors for the hormones estrogen and progesterone. Receptors are special proteins that help the hormones tell cells to grow and divide. Hormone therapy drugs for ILC lower the amount of estrogen in your body or keep it from telling cancer cells to grow. […] Hormone therapy can also reduce the risk of your cancer returning. Your doctor may keep you on hormone therapy for 5-10 years or even longer to protect against recurrence, says Thompson. […] Cancer affects everyone differently. Your outlook may depend on things such as how early youre diagnosed and how well your body responds to treatment. […] In general, about 91% of all women with breast cancer live at least five years after diagnosis. While there isnt much information about specific types of breast cancer, these survival rates are tracked by stage at diagnosis or how far the cancer has spread: Localized (cancer hasnt spread outside the breast): More than 99% live at least five years. Regional (cancer has spread to lymph nodes near the breast): 87% live at least five years. Distant (cancer has spread farther in the body): 32% live at least five years.

• #65 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  There is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. […] The majority of physicians reported being very/extremely (41%) to moderately (42%) confident in describing the differences between ILC and invasive breast cancer of no special type (NST). Knowledge of histology was seen as important (73%) and as affecting treatment decisions (51%), and most agreed that refining treatment guidelines would be valuable (76%). […] The majority of patients and advocates (52%) thought that their health care providers did not sufficiently explain the unique features of ILC. They identified improvement of ILC screening/early detection, and identification of better imaging tools as top research priorities.

• #66 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  In summary, we have gathered information from an international community of physicians, researchers, and patients/advocates that we expect will lay the foundation for a community-informed collaborative research agenda, with the goal of improving management and personalizing treatment for patients with ILC. […] The majority of physicians indicated that there either was no data, that they did not know, or that they were unsure if there were clinical trials and outcome data supporting unique treatments for ILC. Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians, for a number of reasons outlined in Supplementary Text File 2. […] Most physicians (71%) did not mention that ILC can metastasize to unique places and did not discuss what symptoms, including unusual symptoms, of recurrence the patients should report in the future (78%). […] Overall, while there is growing interest in the study and understanding of ILC, there are clear gaps in understanding and presentation of the disease to patients. […] While very few clinical trials have been directed specifically at ILC, most physicians expressed an interest in such trials.

• #67 International survey on invasive lobular breast cancer identifies priority research questions | npj Breast Cancer

  https://www.nature.com/articles/s41523-024-00661-3

  In summary, we have gathered information from an international community of physicians, researchers, and patients/advocates that we expect will lay the foundation for a community-informed collaborative research agenda, with the goal of improving management and personalizing treatment for patients with ILC. […] The majority of physicians indicated that there either was no data, that they did not know, or that they were unsure if there were clinical trials and outcome data supporting unique treatments for ILC. Refining treatment guidelines specifically for lobular breast cancer was seen as valuable for treating patients with ILC in the future by 76% of physicians, for a number of reasons outlined in Supplementary Text File 2. […] Most physicians (71%) did not mention that ILC can metastasize to unique places and did not discuss what symptoms, including unusual symptoms, of recurrence the patients should report in the future (78%). […] Overall, while there is growing interest in the study and understanding of ILC, there are clear gaps in understanding and presentation of the disease to patients. […] While very few clinical trials have been directed specifically at ILC, most physicians expressed an interest in such trials.

• #68 What is invasive lobular carcinoma? | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/What-is-invasive-lobular-carcinoma-8-insights-on-lobular-breast-cancer.h00-159539745.html

  Invasive lobular carcinoma is different from ductal carcinoma. […] Invasive lobular carcinoma isn’t rare. […] Because of the number of diagnoses each year, Mouabbi says it’s important to conduct studies devoted to the subtype to improve care. […] Standard of care treatment not tailored to invasive lobular carcinoma. […] Many patients with invasive lobular carcinoma receive the standard-of-care chemotherapy, but the comprehensive review showed there isn’t much clinical benefit. […] Endocrine therapy is effective in treating invasive lobular carcinoma. […] To define more personalized approaches, Mouabbi says it’s critical to conduct clinical trials specific to lobular breast cancer.

• #69

  https://www.nursingcenter.com/journalarticle?Article_ID=6557167&Journal_ID=401957&Issue_ID=6557118

  To determine how to most effectively treat a cancer subtype, researchers and clinicians must come to understand all characteristics associated with that particular type of cancer. […] Specifically, their analysis demonstrated that ILC and IDC are biologically distinct, leading to the need for specific detection and treatment options for the lobular subtype. […] Williams emphasized that a major takeaway was that invasive lobular breast cancer is a different subtype or disease entity than invasive ductal cancer. […] Although they are treated similarly with surgery and chemotherapy, and if they’re deemed to be high-risk enough [for] endocrine therapy, there’s a definite need for individualized therapies for patients with ILC. […] While Oesterreich confirmed that treatment options for ILC and IDC do not differ, she said there might be some changes in the management of patients, in that physicians start to consider the increase in late recurrences, unique sites of metastases, and challenges with imaging in their decision-making.

• #70

  https://www.nursingcenter.com/journalarticle?Article_ID=6557167&Journal_ID=401957&Issue_ID=6557118

  She explained that more research in ILC imaging and biomarker development is needed to come to any additional conclusions. […] Increased research efforts and increased patient advocacy for ILC over the last 5-10 years have resulted in more research in ILC. […] But we need to do more as the goal is to have personalized treatment for the different histological subtypes, and we need to identify treatments targeted at the unique behavior of the tumors. […] We need to do more molecular characterization of the tumors because we know that ILC cancers have a specific genomic profile compared to invasive ductal cancers. […] Additionally, Williams shared that from a treatment standpoint, she believes researchers need to start designing trials looking at invasive ductal cancer and ILC. […] She also believes there exists a need to develop better screening tools for women with ILC.

• #71 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Adjuvant hormone therapy is also indicated, given the high percentage of cases that are positive for ER and PR. […] Management of invasive lobular breast carcinoma needs an interprofessional approach involving a team that consists of a surgical oncologist, a medical oncologist, a radiation oncologist, a pathologist, a radiologist, and an oncology nurse, all collaborating through disciplines to realize optimal patient results.

• #72

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/invasive-lobular-carcinoma

  Your care team at Aurora Health Care will use a collaborative approach to provide the best treatment possible. Supportive care services such as counseling, nutrition therapy, palliative care and physical therapy may also be offered to help you manage the physical and emotional challenges of cancer treatment.

• #73 Lobular Breast Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554578/

  Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. This activity educates the student about the etiology, epidemiology, clinical evaluation, and the importance of treatment of lobular carcinoma of the breast. […] Summarize interprofessional team strategies for improving care coordination and communication to advance the care of lobular breast cancer and improve outcomes. […] The treatment of invasive lobular carcinomas has been a topic of debate due to the potential bilaterality and multifocality that characterize these tumors. Determining the extent of invasive lobular carcinoma is very important in deciding the treatment modality. The multidisciplinary approach to the treatment includes surgery, hormonal therapy, radiation therapy, and chemotherapy.

• #74 Invasive Lobular Breast Cancer Program | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/breast-oncology/programs/invasive-lobular-breast-cancer

  Our physicians are leaders in the field of invasive lobular breast cancer who can provide detailed education and the most up-to-date treatment information. […] Treatment options include surgery, radiation therapy, and systemic therapy. […] Most patients first undergo surgery to remove the tumor. […] Following surgery, treatment may involve radiation therapy to eliminate any remaining microscopic cancer cells at the site of the tumor. […] Chemotherapy may be given to kill cancer cells that may have escaped into the bloodstream or lymph system; however, not all patients with invasive lobular breast cancer benefit from chemotherapy. […] Invasive lobular breast cancer is usually estrogen receptor-positive, so our medical oncologists may recommend that some patients receive endocrine (hormone) therapy to reduce the amount of estrogen in the body or block its effect.

• #75 Get Lobular Breast Cancer Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/lobular-breast-cancer-treatment

  You may also choose to have breast reconstruction. […] Our breast and plastic surgeons work closely together, making it possible for you to have a mastectomy and reconstruction at the same time. […] Our oncology nurses are here to guide you and your family throughout your breast cancer treatment and recovery. […] This includes helping you manage any treatment side effects. […] Cleveland Clinic offers many additional services and support to get you through this challenging time. […] While lobular breast cancer usually grows slowly, it can still spread if left untreated. […] So, the faster you move toward confirming you have it and starting treatment the better chance you have for good results.

• #76 Lobular Breast Cancer Prognosis and Survival Rates

  https://www.healthline.com/health/breast-cancer/lobular-breast-cancer-prognosis-survival

  Lobular breast cancer starts in the milk-producing lobules and can spread through metastasis. The prognosis depends on factors such as cancer grade and stage and long-term care plans. […] ILC can be hard to diagnose because it spreads in a unique pattern that may not show up on imaging tests. However, its a slow-growing cancer, which gives doctors time to plan treatment. […] Your options include lumpectomy or mastectomy, depending on the stage of cancer, as well as hormonal therapy and chemotherapy. […] Radiation may be necessary after a lumpectomy. Your doctor will create a personalized care plan depending on your health and the latest technologies available. […] If you’ve been treated for ILC, it’s especially important to schedule a physical exam and a mammogram every year after your treatment. The first one should take place 6 months after surgery or radiation therapy is complete.

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