Materiały źródłowe

• #1 Hidradenitis suppurativa – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hidradenitis-suppurativa/diagnosis-treatment/drc-20352311

  Treatment with medicines, surgery or both can help control symptoms and prevent complications of hidradenitis suppurativa. Talk with your health care provider about the risks and benefits of the treatment options and how to develop an approach that’s right for you. […] Your health care provider might prescribe one or more of these types of medicines: […] Antibiotics. An antibiotic applied to the skin in liquid or gel form may be used to manage mild symptoms. These types of medicines are called topical antibiotics. For more widespread disease, your health care provider might prescribe antibiotic pills, such as doxycycline, or Monodox; clindamycin, or Cleocin; rifampin, or Rimactane; or more than one of these medicines. Rifampin also is known as rifampicin. People with severe disease might need to take antibiotics for months.

• #1 Hidradenitis suppurativa – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hidradenitis-suppurativa/diagnosis-treatment/drc-20352311

  Retinoids. Oral retinoids might be an option for some people with acne-like disease. These medicines are not recommended when you’re pregnant, breastfeeding or if you intend to become pregnant. […] Pain medicine. If pain relievers available without a prescription don’t help, your health care provider might prescribe a stronger pain medicine or refer you to a pain clinic. […] Combined medical and surgical approaches help manage hidradenitis suppurativa. Surgery is an important part of disease management when a tunnel, and bump, or abscess, are present. Which surgical approach is right for you depends on the extent and severity of your condition. Talk with your health care provider about the risks and benefits of the options, including: […] Uncovering the tunnels. This procedure involves removing tissue to expose the tunnels under the skin. This also is known as unroofing. It’s used for people with moderate or severe hidradenitis suppurativa. This solution usually doesn’t have to be repeated.

• #1 Hidradenitis suppurativa – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hidradenitis-suppurativa/diagnosis-treatment/drc-20352311

  Steroid injections. Triamcinolone acetonide, or Kenalog-10, injected into the sores might reduce swelling and inflammation. […] Hormonal therapy. Hormone pills, such as estrogen-containing combined oral contraceptives such as estradiol and estradiol/norgestimate might be effective for people with mild hidradenitis suppurativa. Spironolactone often is used to reduce the need for antibiotics, and isotretinoin, which is a medicine that is used mostly to treat acne. Isotretinoin is sometimes used to treat hidradenitis suppurativa. […] Biologics. These medicines, usually administered by injection, alter the immune system in a way that disrupts the disease cycle and improves symptoms and signs of disease within weeks. Several of these medicines are approved to treat moderate to severe hidradenitis suppurativa. Two are the tumor necrosis factor inhibitors adalimumab, or Humira, and infliximab, or Remicade. These medicines work by dampening part of the immune system called tumor necrosis factor. Many other biologics are in clinical trials for hidradenitis suppurativa.

• #1 Hidradenitis suppurativa – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hidradenitis-suppurativa/diagnosis-treatment/drc-20352311

  Punch debridement. This procedure, also called limited unroofing, involves removing a single inflamed bump. […] Laser therapy. A carbon dioxide laser can be used to make hidradenitis suppurativa sores go away. After this treatment, the sores are unlikely to return. Laser hair removal can help hidradenitis suppurativa in its early stages. […] Surgical removal. This approach might be an option for people with persistent or severe symptoms. It involves removing all the affected skin. A skin graft might be needed to close the wound. Even after surgery, sores might still occur in other areas. […] Incision and drainage. Surgical drainage is no longer considered an effective option for treating hidradenitis suppurativa. The method might be considered to provide short-term pain relief, but sores usually flare again afterward.

• #2

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7105662/

  Hidradenitis suppurativa (HS) is a chronic, often debilitating, skin condition that historically does not respond well to treatment. […] The goal of treatment is to prevent the formation of new lesions and to manage the symptoms (most commonly pain and suppuration) of current lesions. […] Treatment for all stages involves prevention of lesion formation, treatment of existing lesions before they develop into chronic sinus tracts, and elimination of existing nodules and sinus tracts before extensive scarring occurs. […] Medical treatment of HS has proven to be historically difficult due to a lack of pathophysiologic insight, but patients symptoms can often be managed with medical therapies alone. […] Treatment is determined based on the Hurley staging system, with topical therapies used as first-line therapy for less invasive disease and systemic antibiotics or biologics, surgery, and light therapy reserved for more extensive disease.

• #2

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7105662/

  Topical clindamycin is often the first-line therapy for mild HS, with evidence from multiple trials supporting its efficacy, relative safety, and tolerability. […] Patients with more invasive HS may benefit from systemic antibiotics. […] Patients who do not respond to oral tetracyclines may try the combination of clindamycin and rifampin. […] Surgical removal of lesions is a final, definitive treatment option for patients with Stage II or III disease, especially those with extensive, recurrent HS lesions. […] Patients with refractory disease not responsive to oral antibiotics, oral retinoids, or hormonal therapy may benefit from tumor necrosis factor (TNF)-alpha inhibitors. […] Emerging therapies for Hurley stage III HS include the IL-12/23 receptor antagonist ustekinumab, IL-1 receptor antagonists anakinra and canakinumab, and IL-1 alpha inhibitor MABp1. […] If multiple medical therapies have failed, patients with Hurley stage III lesions should be referred to plastic surgery or general surgery for excision of lesions.

• #3 Hidradenitis Suppurativa: Causes, Symptoms, Diagnosis, Stages, and Treatment

  https://www.webmd.com/skin-problems-and-treatments/hidradenitis-suppurativa

  There’s no cure for HS. It’s an ongoing skin condition you may need to manage for years. The right treatments can ease your symptoms and help prevent flares. […] Your treatment will be based on how severe your case is. You and your doctor might have to try multiple treatments to find the one that works best for you. […] Treatment options include: […] Warm compresses. You might try this first if your case is mild. Run a clean washcloth under hot water and hold it on your skin for 10 minutes. […] NSAIDs (nonsteroidal anti-inflammatory drugs). These over-the-counter medicines can ease your pain and help manage swelling. They include: Aspirin, Ibuprofen, Naproxen. […] Antibiotics. These medications fight infections. You can swallow them as a pill, or you can use a cream, ointment, cleanser, wash, or gel on your skin.

• #4 Hidradenitis suppurativa: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-treatment

  Getting an accurate diagnosis and an individualized treatment plan can help prevent this condition from worsening. […] If you have hidradenitis suppurativa, your dermatologist will create a treatment plan tailored to your needs. […] While this condition cannot be cured, your dermatologist will create a treatment plan that can: Reduce flare-ups, Heal wounds, Relieve pain and itch, Prevent the condition from worsening, Allow you to participate comfortably in regular activities, such as walking and exercise. […] When creating a treatment plan, your dermatologist considers the types of bumps and sores you have, whether you have pain or an infection, and how the condition is affecting your life. This allows your dermatologist to customize a treatment plan for your specific needs. […] Your treatment plan may include one or more of the following: Some soaps and other skin care products may irritate skin with hidradenitis suppurativa. To reduce irritation, your dermatologist can create a skin care plan for you. This plan may include using an antibacterial wash and switching to a gentle antiperspirant.

• #4 Hidradenitis suppurativa: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-treatment

  If you have nodules (hard lumps beneath your skin), cysts (lumps that may contain pus, oil, or another substance), or abscesses (infected lumps that contain pus), your dermatologist may prescribe: A topical (applied to the skin) antibiotic called clindamycin is often prescribed to treat mild hidradenitis suppurativa. This medication can reduce lumps, including lumps that contain pus, and pus-filled swollen areas beneath your skin. It can also help treat an infection. […] Resorcinol cream: This is a peel that can open clogged hair follicles and reduce inflammation. […] When stronger treatment is needed, your dermatologist may prescribe: Oral (taken by mouth) antibiotic: Antibiotics are frequently prescribed to treat hidradenitis suppurativa. An antibiotic can reduce inflammation and bacteria that cause flare-ups on your skin.

• #4 Hidradenitis suppurativa: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-treatment

  Hormonal therapy: For some women, hormonal therapy may be helpful. […] Biologics and biosimilars: Biologics differ from other types of medications in that they are made from a living organism, like plant cells or animal cells. Biologics work on part of your immune system. The biologics used to treat hidradenitis suppurativa are designed to reduce inflammation. […] Some patients can benefit from a treatment plan that uses both medication and an in-office procedure. […] Procedures that dermatologists use to treat hidradenitis suppurativa include: Corticosteroid injection: When injected into a nodule, this medication can reduce inflammation. […] Your dermatologist may recommend this to drain a painful bump. An in-office surgical procedure can also be used to remove an abscess (pus-filled area), tunnel beneath your skin, or lesion that keeps returning after treatment.

• #4 Hidradenitis suppurativa: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-treatment

  This plays an important role in treating hidradenitis suppurativa, as this condition can cause slow-healing or non-healing wounds. […] If you have developed depression or anxiety, your dermatologist may recommend counseling or joining a hidradenitis suppurativa support group. […] To help their patients get the best outcome from treatment, dermatologists recommend self-care.

• #5 Hidradenitis suppurativa (HS)

  https://www.nhs.uk/conditions/hidradenitis-suppurativa/

  Hidradenitis suppurativa is a lifelong, recurring condition that is often difficult to manage, although the symptoms may improve or eventually stop with treatment. […] In the early stages, it may be controlled with medicine. Surgery may be required in severe or persistent cases. […] If you have lumps that are particularly painful, inflamed and oozing pus, you may be prescribed a 1- or 2-week course of antibiotics, if test show that you have a bacterial infection. […] If bacterial infection is not present, low doses of antibiotics may be used to prevent inflammation. This longer course of antibiotics will last at least 3 months, to reduce the number of lumps that develop. […] In severe cases of hidradenitis suppurativa, a combination of clindamycin and rifampicin can be effective. […] Antiseptic washes, such as 4% chlorhexidine, applied daily to affected areas are often prescribed alongside other treatments.

• #5 Hidradenitis suppurativa (HS)

  https://www.nhs.uk/conditions/hidradenitis-suppurativa/

  Retinoids, such as acitretin, are vitamin-A based medicines that help some people with hidradenitis suppurativa. […] If hidradenitis suppurativa flares up before a period you may benefit from taking oral contraceptives. […] In severe cases of hidradenitis suppurativa, treatments that suppress the immune system, such as adalimumab or infliximab, can be useful. […] Rarely, you may be prescribed steroids, such as prednisolone, to reduce severely inflamed skin. […] Surgery may be considered in cases where hidradenitis suppurativa cannot be controlled with medicine.

• #6 Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

  https://www.mdpi.com/2077-0383/11/23/7240

  In cases of mild-to-moderate disease with limited extent, topical therapy can be considered. Topical clindamycin 1%, applied twice daily on involved areas, is the first-line treatment option for mild-to-moderate disease, especially in absence of deep inflammation or sinus tracts. […] In a small prospective study, topical clindamycin effectively reduced inflammatory lesions compared to placebo. […] Systemic antibiotic therapy is recommended as first-line therapy for patients with Hurley stage II and moderate-to-severe disease and as second-line therapy for patients who do not respond on oral tetracycline treatment. […] Adalimumab, a fully human, IgG1 monoclonal antibody specific for TNFα, is currently the only biologic therapy approved for the treatment of moderate-to-severe HS in adults and adolescent patients ≥12 years.

• #6 Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

  https://www.mdpi.com/2077-0383/11/23/7240

  Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. […] Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available. […] In recent years, increased research has led to the identification of new potential therapeutic targets. This review aims to give a comprehensive and practical overview of current treatment options for HS. Furthermore, the clinically most advanced novel treatment approaches will be discussed. […] Clinical management of HS is often complex and includes medical and surgical treatments, which are often combined, especially in moderate-to-severe disease. […] The reduction of symptoms and inflammation activity as well as prevention of formation of chronic HS lesions and scarring represent key therapeutic goals. In current guidelines, an individualized patient-oriented approach, based on the individual subjective impact and objective disease severity, is recommended.

• #6 Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

  https://www.mdpi.com/2077-0383/11/23/7240

  In two phase III multicenter, double-blind, placebo-controlled studies (PIONEER I and PIONEER II) adalimumab showed a significant effectivity compared to placebo with HiSCR rates of 41.8% and 58.9%. […] The therapy is usually well tolerated with injection side reactions being the most common side effects and large meta-analyses have shown non-significant safety issues compared to placebo. […] Several promising novel treatment approaches, including antibodies, nanobodies, small molecules and hormonal treatments, are currently being investigated in clinical studies and could enrich the therapeutic spectrum for HS.

• #7 Hidradenitis Suppurativa Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1073117-treatment

  The aim of one study was to evaluate the efficacy of hyperbaric oxygen therapy (HBO) as an adjunctive therapy in patients treated with a combination of rifampin and clindamycin. Adjunctive HBO was considered to yield a significant improvement in the efficacy of antibiotic treatment of HS. […] Clindamycin at 300 mg twice daily in combination with rifampin at 300 mg twice daily was recommended in a 2012 clinical practice article by Jemec, especially in light of the emerging presence of methicillin-resistant S aureus (MRSA). […] Systemic treatment with a combination of rifampin-moxifloxacin-metronidazole, either alone or preceded by systemic ceftriaxone treatment, has been recommended for resistant stage II and III disease. After 12 weeks of initial treatment, the therapy should be continued for an additional 12 weeks using a combination of moxifloxacin and rifampin.

• #7 Hidradenitis Suppurativa Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1073117-treatment

  Alikhan et al suggested a treatment algorithm based upon the Hurley classification or a tiered approach. For patients in Hurley stage I, antibiotics and intralesional injections of corticosteroids represent a good first-line therapy, while flares should be treated with short courses of systemic corticosteroids. If this regimen fails, zinc, or, in females of non-childbearing age, antiandrogen therapy may be effective. Long-term immunosuppressive therapy including biologics or surgical therapy may be required in some patients. For patients in Hurley stage III, wide excision may prove to be the only effective treatment. […] Promising biologics include the anti-interleukin (IL)-17 antibodies secukinumab and bimekizumab (now approved by the US Food and Drug Administration [FDA] for treatment of HS in adults). An anti-IL-1 biologic, bermekimab, is showing encouraging results.

• #7 Hidradenitis Suppurativa Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1073117-treatment

  In 2024, the FDA approved bimekizumab, which selectively inhibits IL-17F in addition to IL-17A, for use in adults with HS. Approval was supported by data from two phase 3 studies (BE HEARD I, BE HEARD II) in which bimekizumab improved the signs and symptoms of disease as compared with placebo at week 16. Results were sustained to week 48. […] More, larger RCTs are required to investigate most HS interventions, particularly oral treatments with biologics. There is moderate-quality evidence to suggest that adalimumab given weekly and infliximab are effective, whereas adalimumab every other week is ineffective. […] The suggested dosage and duration of isotretinoin treatment are similar to those proposed for severe forms of acne vulgaris (0.5-1.2 mg/kg/day for 4-12 mo). However, the presence of acne vulgaris or of a history of previous acne has not been found to affect outcome.

• #7 Hidradenitis Suppurativa Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1073117-treatment

  Dapsone therapy with 25-200 mg/day should be initiated if standard first- or second-line agents fail. There are no data on maximum duration of therapy (reported range, 3-48 mo). […] Intralesional steroid injection with either a syringe or an automatic needleless injector usually decreases the size of draining sinuses. The injection of 0.05-0.25 mL of triamcinolone acetonide suspension (2.5-10 mg/mL) into each lesion (up to 3-6 mL per visit) is recommended for its anti-inflammatory effects. This treatment can be repeated every 2-3 weeks if necessary. […] Data on the use of corticosteroids in HS are limited. The anti-inflammatory effects of systemic corticosteroids may be useful in acute exacerbations. Prednisolone at 60 mg/day with lower maintenance doses provides some long-term control. Oral prednisone reduces inflammation, facilitates the healing of existing HS lesions, and prevents future lesions from forming.

• #8 Hidradenitis suppurativa: Management – UpToDate

  https://www.uptodate.com/contents/hidradenitis-suppurativa-management

  Incision and drainage […] Initial therapy […] Oral tetracyclines […] Clindamycin and rifampin […] Metformin, oral contraceptives, and spironolactone […] Failure of initial therapy […] Adalimumab […] Acitretin […] Failure of adalimumab […] Secukinumab […] Bimekizumab […] Infliximab […] Severe, refractory disease […] Wide excision […] Medical therapies […] Ustekinumab […] Anakinra […] Intravenous ertapenem […] Other therapies […] Nd:YAG laser […] Rifampin, moxifloxacin, and metronidazole […] Apremilast […] Zinc supplementation […] Other oral retinoids.

• #9 Hidradenitis Suppurativa: Causes, Symptoms, Diagnosis, Stages, and Treatment

  https://www.webmd.com/skin-problems-and-treatments/hidradenitis-suppurativa

  At first, you may use doxycycline or minocycline for 2 to 3 months. If that doesn’t help, your doctor may suggest a combination of clindamycin and rifampin (Rifadin, Rimactane). […] Corticosteroids. Your doctor injects these medicines into the bumps. They can ease inflammation, pain, and swelling. You usually get these shots once a month for up to 3 months. If your case is severe, your doctor may recommend that you take steroid pills by mouth. […] Oral retinoids. Your doctor may suggest a retinoid medication in a pill such as acitretin (Soriatane) or isotretinoin (Accutane). Both can improve severe cases of HS. […] Topical resorcinol. This is a cream that you put on inflamed areas of your skin. It has chemicals that peel the skin. […] Hormone therapy. Some women find that their condition gets better if they take birth control pills or a drug called spironolactone.

• #10 diagnosis and treatment of hidradenitis suppurativa | UAMS Department of Family and Preventive Medicine

  https://medicine.uams.edu/familymedicine/tag/diagnosis-and-treatment-of-hidradenitis-suppurativa/

  The next level is topical treatments. She typically uses clindamycin 1%; however, resorcinol 15% elicits a better response in mild to moderate HS. […] Dr. Shi’s office typically starts with the tetracycline family because it’s better at reducing inflammation in the hair follicle and less costly. […] Dr. Shi recommends these hormonal / metabolic therapies: Hormonal and Metabolic Therapies For Women – Spironolactone 50 – 150 mg daily. Monophasic OCP (with increased estrogen and with anti-androgenic progestin such as drospirenone) For Men Finasteride 5-10 mg daily For Both – Metformin 500 mg – 1500 mg daily (for patients who are obese or have diabetes). […] Biologics is the last step of treatment. Dr. Shi said providers should learn the basics of biologics so they can explain how it works before they refer to a dermatologist. The patient must be on at least 90 days of an oral antibiotic before most insurance will allow biologics.

• #11 Hidradenitis Suppurativa Clinic | GW Medical Faculty Associates

  https://gwdocs.com/specialties/dermatology/hidradenitis-suppurativa-clinic

  Metformin, which is approved by the U.S. Food and Drug Administration for the treatment of adult-onset diabetes (type II diabetes), also may help people who have HS and a condition called metabolic syndrome. […] Medicines that regulate hormones, including birth control pills and spironolactone, can decrease pain and the amount of fluid draining from HS breakouts. […] Drugs that target the immune system, biologics like adalimumab (Humira) and secukinumab (Cosentyx) which are both FDA, may be used to treat moderate to severe HS. […] Retinoids can stop the pores from producing too much oil, which helps prevent clogged hair follicles. This treatment will only work in certain HS patients.

• #12 Hidradenitis Suppurativa Treatment | HUMIRA® (adalimumab)

  https://www.humira.com/hidradenitis-suppurativa/treatment.html

  HUMIRA is the first and only FDA-approved treatment for HS for people 12 years and older. […] HUMIRA targets and blocks TNF-alpha, a specific source of inflammation that is thought to contribute to HS symptoms. Many adult HS patients who used HUMIRA in clinical trials experienced significant relief of signs and symptoms. […] HUMIRA was proven in many adult patients to reduce the total number of inflammatory nodules and abscesses by at least half without an increase in draining wounds and abscesses in just 3 months. […] HUMIRA is a prescription medicine used to reduce the signs and symptoms of moderate to severe hidradenitis suppurativa in people 12 years and older.

• #13 Hidradenitis Suppurativa: Advancing Treatment With Biologics

  https://www.ajmc.com/view/hidradenitis-suppurativa-advancing-treatment-with-biologics

  Hidradenitis suppurativa is managed with biologics like adalimumab and secukinumab, approved for moderate-to-severe cases. […] Adalimumab, a TNF- inhibitor, was FDA-approved in 2015, while secukinumab, an IL-17A inhibitor, was approved in 2023. […] Treatment strategies consider patient-specific factors, including age, comorbidities, and immunosuppression risks. […] Loss of response to biologics is common, with therapeutic drug monitoring used to identify treatment failures. […] Ongoing research is crucial to optimize biologic therapies and identify the best options for individual patients. […] Adalimumab and secukinumab are the only FDA-approved biologic drugs to treat hidradenitis suppurativa, limiting options for patients, especially those who experience loss of response. […] Hidradenitis suppurativa (HS) can be managed with either adalimumab or secukinumab, both valuable treatment options, but ongoing research is crucial to identify the best biologic therapies for individual patients while optimizing long-term outcomes.

• #14 Hidradenitis Suppurativa | BIMZELX® (bimekizumab-bkzx)

  https://www.bimzelx.com/hidradenitis-suppurativa

  Discover a treatment that works differently for adults with moderate-to-severe hidradenitis suppurativa (HS) symptoms. BIMZELX is the only FDA-approved biologic that selectively inhibits the two immune system proteins IL-17A and IL-17F (interleukins), key drivers of inflammation. BIMZELX is a prescription medicine used to treat adults with moderate-to-severe hidradenitis suppurativa. In two clinical studies, 48% and 52% of people saw at least a 50% reduction in the number of inflamed nodules and abscesses, with no increase in abscesses or draining tunnels, at 16 weeks (vs 29% and 32% taking placebo). Results are from a 320-mg dose of BIMZELX, given as an injection under the skin every 2 weeks for 16 weeks. Results may vary. Everyone responds to treatment differently. In a separate analysis, nearly 3 out of 5 people saw at least a 50% reduction of HS symptoms at week 16 and of those 89% of people maintained it for up to one year. BIMZELX is a medicine that affects your immune system and may increase your risk of serious side effects, including suicidal thoughts and behavior, serious infections including tuberculosis, liver problems, and inflammatory bowel disease. The most common side effects of BIMZELX in people treated for moderate-to-severe hidradenitis suppurativa include: upper respiratory tract infections, headache, herpes simplex infections (cold sores in or around the mouth), small red bumps on your skin, feeling tired, fungal infections (oral thrush or infection in the mouth, throat, skin, nails, feet, or genitals), pain, redness or swelling at injection site, stomach flu (gastroenteritis), and acne.

• #15 Hidradenitis Suppurativa – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK534867/

  Other therapies that may be considered include neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, ustekinumab, anakinra, bimekizumab, guselkumab, canakinumab, cyclosporine, tacrolimus, apremilast, zinc, photodynamic therapy, golimumab, risankizumab, liraglutide, microwave ablation (not currently recommended), cryoinsufflation, botulinum toxin injections, and ionizing radiation.

• #16 Management of hidradenitis suppurativa: an Australasian consensus statement

  https://dermnetnz.org/topics/hidradenitis-suppurativa-guidelines

  Adalimumab also reduces HS-associated pain. […] Wound care in HS aims to manage odour, pain, and exudate (which is sometimes profuse), and minimise bacterial colonisation and secondary infection. […] Topical therapies alone may be effective in mild HS where there are no deep inflammatory lesions, and they are commonly used as adjunctive therapy in more severe disease. […] Systemic antibiotics are widely used in treatment, both short-term for the control of acute infective episodes and long-term for their presumed immunomodulatory properties. […] Dapsone has been used in HS, based on efficacy in patients with mild to moderate disease. […] Many dermatologists commence treatment with doxycycline or minocyline 100 mg daily to determine efficacy, increasing to 100 mg twice daily if necessary.

• #16 Management of hidradenitis suppurativa: an Australasian consensus statement

  https://dermnetnz.org/topics/hidradenitis-suppurativa-guidelines

  Systemic corticosteroids are widely prescribed for their anti-inflammatory effect, and clinical experience suggests that they are beneficial as rescue therapy in managing flares. […] The TNF inhibitors infliximab and adalimumab have been assessed in RCTs. […] Surgery is an effective adjunct to medical treatment for HS but no randomised controlled trials have assessed this approach. […] Laser and light-based therapies have the potential to reduce the frequency of painful flares by decreasing the number of hair follicles, sebaceous glands and bacteria in affected areas. […] Further efforts are required to educate healthcare professionals and the general public about HS, and to encourage research on its epidemiology and pathophysiology.

• #16 Management of hidradenitis suppurativa: an Australasian consensus statement

  https://dermnetnz.org/topics/hidradenitis-suppurativa-guidelines

  Comprehensive care of HS should include encouragement of smoking cessation and weight control, wound care, and management of pain, itch and psychosocial health. […] Topical therapies alone may be effective in mild HS. […] Systemic antibiotics are widely used short-term for the control of acute infective episodes and long-term for their presumed immunomodulatory properties. […] Adalimumab is the only biologic registered in Australia and New Zealand for the treatment of HS. […] Surgery is an effective adjunct to medical treatment for HS. […] Laser therapy, photodynamic therapy and intense pulsed light can also be useful adjuncts to medical therapy. […] Early diagnosis and timely referral to expert care are the key to achieving effective multimodal care of HS. […] Not smoking is associated with a better response to treatment and a 15% weight reduction in obese patients ameliorates disease severity.

• #17 Hidradenitis suppurativa – Management, comorbidities and monitoring

  https://www.racgp.org.au/afp/2017/august/hidradenitis-suppurativa-management-comorbidities

  Recommended antibiotic monotherapy is with minocycline or doxycycline; the efficacy is most probably related to their anti-inflammatory properties. […] Short-term systemic corticosteroid therapy is highly effective in HS for debilitating pain and acute flares with abscess formation. […] Effective biologic agents for HS are largely the tumour necrosis factor alpha inhibitors (anti-TNFs) adalimumab and infliximab. […] Surgical intervention is most useful as adjuvant therapy for medically non-responsive lesions, and after a referral for review by a dermatologist experienced in managing HS. […] Treatment of comorbidities follows standard medical guidelines. […] Local wound care is useful in preventing unnecessary scarring, psychological embarrassment due to wound suppuration and smell, and pain. […] HS is a complex medical condition with profound psychological impact. Early disease-modifying intervention is often delayed because of a lack of recognition and understanding among healthcare professionals.

• #18 Hidradenitis suppurativa – British Skin Foundation

  https://knowyourskin.britishskinfoundation.org.uk/condition/hidradenitis-suppurativa/

  Biologic injection treatments are designed to suppress the immune system and are used for moderate to severe HS that has not improved with other medical treatment. These biologic treatments include adalimumab, secukinumab and bimekizumab which is injected under the skin, and infliximab, initially given as an intravenous infusion. […] Surgical treatment: Scarring such as skin tunnels usually requires surgery for correction. One option is deroofing under local anaesthetic, where the roof of the tunnels is removed, which allows them to heal naturally over a few weeks. Larger or deeper areas of scarring may require wide-scale removal under general anaesthetic. Wider procedures are more likely to reduce the chance of HS coming back in the treated area, compared to smaller procedures, but healing times are generally longer. HS surgery is more effective in combination with medical treatment and biologic therapy is usually continued. Biologic therapy may be paused if non-HS internal surgery is needed.

• #19 Hidradenitis Suppurativa Treatment Near Me Marlton NJ | South Jersey

  https://hmgsderm.com/hidradenitis-suppurativa/

  Hormonal drugs: Oral contraceptives, spironolactone, finasteride are sometimes used for chronic disease. […] Biologic agents: Humira (adalimumab) subcutaneous injection may be used for moderate to severe disease in patients 12 and older. Other biologics used in our practice include IL-12/23 inhibitors, infliximab, and IL-17 inhibitors. […] Anti-inflammatory drugs: Zinc, dapsone, acitretin/isotretinoin, metformin, prednisone, and methotrexate are less frequently used for recalcitrant disease. […] Uncovering tunnels: Also known as unroofing, this involves removing tissues to expose the tunnels beneath the skin. […] Punch debridement: Also called limited unroofing, this may be used to remove a single inflamed nodule. […] Surgical removal: For individuals with persistent or severe symptoms, surgical removal may be an option. Individual lesions can be treated with Incision and Drainage or Simple Excision. In more extensive disease, all of the affected skin is removed, and a skin graft may be needed to close the wound. It is important to understand that sores may still occur in other areas of the body after surgery.

• #20 Help for hidradenitis suppurativa in Westlake, OH

  https://www.healthyskinmd.com/hidradenitis-suppurativa/

  Dr. Hazen helped to pioneer laser therapy for HS. This procedure is performed on an outpatient basis at Associates in Dermatology, with only local anesthetic needed. A carbon dioxide laser is used to remove sinus tracts and extensions in the affected area. Because these tunnels are not visible, they can easily be missed by other treatment approaches. […] The condition resides in deeper layers of skin, so laser excision does not involve muscles. The surgical site typically heals within ten weeks, and recurrence in treated areas is rare. Multiple treatment sessions may be necessary for extensive HS. […] This groundbreaking treatment is bringing new hope to those who live with HS. Call (440) 482-8323 to schedule a consultation at Associates in Dermatology. […] Treatments you know everyone has looked for the differences of what may help this disease and its almost I think helpful to divide the treatments and their focus into those things that are geared at trying to control the right now inflammation of that spot right at the moment versus those treatments that try to get rid of the more lasting chronic kinds of things in general for either very limited and early stage 1 for example kind of thing all of the focus of treatment is to try to get that area so theyve done hurting and these anti-inflammation things sometimes theyre used as shots of medicine directly into the spots of the boils sometimes they may be antibiotics although interesting land and of addicts dont work because theyre killing germs they work as, and, inflammation beaches thats one of the importance in concepts of this because you know you take an antibiotic for a boil and the infection is clear enough in a few days up to a week or more this is not something that youre taking just to kill germs and as such its a medicine that people will need to take as an antibiotic perhaps for many months or even longer and one must be able to choose medicines that if theyre needed for a longer period that are safe to take is like treating high blood pressure is like treating diabetes you dont take medicine for a week you take the medicine for as long as that condition needs to be kept under control and youd be kept in therapy.

• #21 Hidradenitis Suppurativa Treatments

  https://www.umassmed.edu/hs-center/treatments/

  Reduces plugging of the hair follicles by blocking the activity of androgen hormones. […] For female patients, we may recommend an oral contraceptive pill that contains drospirenone or cyproterone acetate, as these have anti-androgen activity. […] Spironolactone is another anti-androgenic oral medication that can be used to treat HS. […] Metformin has been used successfully to improve HS, as it can help to reduce the levels of androgens from excess insulin levels. […] Doxycycline and Augmentin are commonly prescribed antibiotics that can be taken for days to months to help control HS. […] Adalimumab (HumiraTM) and Secukinuma (CosentyxTM) are the only two biologic medications that are approved by the FDA to treat HS. […] Laser hair removal selectively targets and destroys hair follicles, which can help prevent new HS lesions from forming in hair-bearing areas of the underarms and pubic area.

• #22 Hidradenitis Suppurativa: Rapid Evidence Review | AAFP

  https://www.aafp.org/pubs/afp/issues/2019/1101/p562.html

  Hidradenitis suppurativa is a chronic folliculitis affecting intertriginous areas. […] Treatment includes wearing loose-fitting clothes, losing weight if overweight, and smoking cessation. Topical clindamycin alone can be effective for patients with mild disease. Patients with moderate disease can be treated with oral antibiotics, such as tetracyclines, in addition to topical clindamycin. Adalimumab, a tumor necrosis factor alpha inhibitor, is effective for patients with moderate to severe hidradenitis suppurativa. Surgical procedures are often necessary for definitive treatment and include local procedures, such as punch debridement and unroofing/deroofing. Wide excision is indicated for patients with severe, extensive disease and scarring. […] Patients with hidradenitis suppurativa should be counseled on ways to prevent worsening symptoms or flare-ups, including wearing loose-fitting clothes to prevent friction, although evidence for this is limited; weight loss if overweight; and smoking cessation. A 15% weight loss is associated with significant improvement in disease severity.

• #23 Hidradenitis Suppurativa – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/acne-and-related-disorders/hidradenitis-suppurativa

  Hidradenitis suppurativa is currently thought to be a chronic inflammatory condition of the hair follicle and associated structures. […] Treatment of Hidradenitis Suppurativa […] Stage I: Topical clindamycin, intralesional corticosteroids, and oral antibiotics […] Stage II: Longer courses of oral antibiotics, antiandrogenic agents, and sometimes drainage, de-roofing, or punch debridement […] Stage III: Infliximab, adalimumab, or secukinumab and often wide surgical excision and repair or grafting. […] Hidradenitis suppurative treatment goals are to prevent new lesions, reduce inflammation, and remove sinus tracts. […] For Hurley stage I disease, typical treatment includes topical 1% clindamycin solution 2 times a day, topical resorcinol 15% cream once a day, oral zinc gluconate (90 mg once a day), intralesional corticosteroids (eg, 0.1 to 0.5 mL of a 5- to 10-mg/mL solution of triamcinolone acetonide once a month), and short (eg, 7- to 10-day) courses of oral antibiotics.

• #23 Hidradenitis Suppurativa – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/acne-and-related-disorders/hidradenitis-suppurativa

  For Hurley stage II disease, treatment is with a longer (eg, 2- to 3-month) course of the same oral antibiotics used to treat stage I disease; if response is incomplete, clindamycin and/or rifampin may be added to the regimen. […] For Hurley Stage III disease, medical and surgical therapy should be more aggressive. Evidence of efficacy in reducing inflammation is strongest for infliximab. […] Wide surgical excision and repair or grafting of the affected areas is often necessary if the disease persists. […] Recommended adjunctive measures for all patients with hidradenitis suppurativa include maintaining good skin hygiene, minimizing trauma, providing psychological support, and possibly avoiding high glycemic-load foods.

• #24 Hidradenitis Suppurativa Treatment San Diego | MedDerm

  https://medderm.net/hidradenitis-suppurativa-treatment/

  For Stage III HS, wide and deep excision surgery may be beneficial. For Stage III HS, medical treatment may be only palliative (it may only reduce the severity of outbreaks). Biologic drug therapies, intralesional steroid and short courses of low-dose prednisone are used in combination in Stage III HS when surgery is not the chosen approach (and sometimes even in patients that have previously undergone surgery).

• #25 Hidradenitis suppurativa: Self-care

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-self-care

  Patients often ask their dermatologist if they should squeeze hidradenitis suppurativa (HS). The answer is no. Squeezing or popping the nodules, cysts, and sores can injure or irritate your skin. Anything that injures or irritates your skin can worsen HS. […] To help their patients who have hidradenitis suppurativa (HS) get the best results from treatment, here’s what dermatologists recommend you do at home: […] Wash your skin with an antimicrobial wash. This helps reduce bacteria on your skin. When there’s less bacteria, you may have fewer flare-ups. […] Quit scrubbing your skin. Patients often think that having HS means they have dirty skin. You don’t have dirty skin. If you’re scrubbing your skin to get it clean, stop. Scrubbing causes inflammation, which can worsen HS. […] Consider laser hair removal as a way to remove hair where you have HS. Studies have shown that getting laser hair removal can reduce flare-ups of HS.

• #25 Hidradenitis suppurativa: Self-care

  https://www.aad.org/public/diseases/a-z/hidradenitis-suppurativa-self-care

  If HS has caused wounds, your dermatologist will create a treatment plan to help heal wounds and prevent infection. […] Patients who quit smoking or lose extra weight can have fewer HS flare-ups (and sometimes get rid of) hidradenitis suppurativa. […] For many patients who are overweight and have HS, losing weight can reduce flare-ups and prevent HS from worsening. […] Quitting smoking can help you live a longer, healthier life. It can also reduce HS flare-ups and prevent HS from worsening. […] While these self-care tips can help, HS may affect your skin in different ways. By working one-on-one with a board-certified dermatologist, you can find what works best for you.

• #26 How Hidradenitis Suppurativa Is Treated

  https://www.verywellhealth.com/hidradenitis-suppurativa-treatment-4777730

  Sometimes boils caused by hidradenitis suppurativa burst, leaving behind open wounds. To help them heal and prevent infection: Gently wash the area daily with an antiseptic cleanser. […] If you develop a chronic bacterial infection as a result of your hidradenitis suppurativa, soaking in a highly diluted bleach bath may help kill the bacteria and prevent future infections. […] Certain foods have been found to worsen HS symptoms. If any of these are a regular part of your diet, you may want to avoid them for a time to see if your skin clears up: Dairy, Sugar, Tomatoes, Eggplant, Potatoes. […] There’s a strong link between cigarette smoking and hidradenitis suppurativa. If you smoke, you may have fewer flare-ups and less severe symptoms. […] You may be able to relieve mild pain and inflammation with over-the-counter (OTC) drugs and skincare products from your local pharmacy.

• #27 Hidradenitis Suppurativa (HS) Aventura, FL | Skin Cancer Treatment Aventura, FL

  https://www.drresnik.com/hidradenitis-suppurativa-hs-cosmetic-dermatologist-miami-florida.php

  How is Hidradenitis Suppurativa treated? Treatment depends on severity. Treatment may just involve medications that are used on the skin or taken orally. Long term and very low dose isotretinoin (formerly Accutane) or acitretin can help prevent new plugging. Surgery of various types is useful in all stages. […] To decide the best treatment for you it is important to know how severe your problem is and this is done with a staging system that is referred to as Hurley’s Criteria. […] General treatment It is important to reduce any friction in the areas where you have recurrent spots. Change to loose cotton clothing such as loose boxer shorts, avoid underwear with seams that rub in areas that give you new lesions. Try to wear clothing that is loose and cool so that you are not overheated and sweating in those areas. Take fresh underwear and a ZiplocR bag to work and change during the day.

• #28 HS Treatment and Management | HS Awareness | HCP

  https://www.hs-awareness.com/treatment-and-management

  The window of opportunity for early intervention can be critical. Early intervention with systemic treatment can help control inflammatory activity and avoid a destructive disease course. The current standard of care requires a multidisciplinary and individualized approach. While there are no curative treatments, pharmacological approaches and other interventions could help. Today’s treatment options encompass several approaches, including lifestyle modifications, topicals, and surgery. Treatments should be individualized according to a patient’s needs. A multidisciplinary care team is essential throughout a patient’s journey. Management strategies should be coordinated by an HS-treating dermatology provider, but a full team can be comprised of numerous specialties depending on a patient’s specific needs. Additional care may be implemented by other healthcare providers, such as urologists and endocrinologists, among others. HS is a systemic condition requiring prompt action to help limit disease progression. Mild cases can often be managed by topical treatments and lifestyle adjustments. Moderate or severe cases may require more. Consider treatment strategies based on the individual. Topical treatment of HS includes skin cleansers, keratolytic agents, and a topical antibiotic. These options may work for some patients, depending on disease severity. Immunomodulation is rapidly becoming the mainstay of therapy for patients with moderate to severe HS. Systemic antibiotics have been a cornerstone of HS treatment for years. Monotherapy is possible for mild HS, but in advanced states, antibiotics may not be as effective for some patients. Deroofing is a technique in which abscesses and associated sinuses are probed, and the skin overlying the sinus or abscess cavity is removed stepwise, with the base left untreated. Incision and drainage have been associated with recurrence rates approaching 100%. However, these procedures can provide some acute relief when other methods do not. Recommendations for postsurgical and nonsurgical HS wound care are based on limited evidence, may be costly, and could be complex based on the severity of a patient’s condition. Wide local excision may result in positive outcomes where the excision was performed, although excision may typically be limited to a superficial subcutaneous plane. HS is associated with numerous comorbidities. Smoking cessation and weight loss counseling should be considered, among other lifestyle modifications. Treatment requires an individualized approach.

• #29 Hidradenitis suppurativa | Institut Pasteur

  https://www.pasteur.fr/en/medical-center/disease-sheets/hidradenitis-suppurativa

  Surgical treatments: Incision and drainage of abscesses for rapid relief. Local or wide excision of the affected areas in severe cases to clear regions containing biofilms. Surgical treatment is only effective if combined with medical treatment, both before surgery to optimize the procedure and after surgery to prevent relapses once biofilms have been removed. […] A multidisciplinary approach involving dermatologists, surgeons and specialists is often needed to optimize treatment. […] Possible remission in certain cases with targeted treatment. The Pasteur-Necker team has hypothesized that HS is caused by immune deficiency localized in the skin, since patients have no systemic infections. […] With a targeted treatment strategy based on bacterial isolates and severity, cases of full remission have been observed, but they have been followed by relapse in the absence of maintenance treatment.

• #30

  https://www.jci.org/articles/view/186744

  Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease that affects approximately 1% of the Western population (1). […] Despite these barriers, the results from recent clinical trials and cellular and molecular studies have crucially shifted our understanding of HS disease pathogenesis, providing insights into treatment successes and failures (Figure 1). […] In this trial, 72.7% of patients treated with remibrutinib achieved the simplified Hidradenitis Suppurativa Clinical Response score (HiSCR) (4). […] Furthermore, an open-label study involving 20 HS patients treated with fostamatinib, an SYK inhibitor, demonstrated an impressive 85% HiSCR response rate after only 12 weeks (5). […] Importantly, anti-TNF therapy, the first registered biologic treatment for HS, has been shown to primarily target B cell activation, with minimal impact on other inflammatory pathways (8).

• #30

  https://www.jci.org/articles/view/186744

  Together, these studies underscore the critical role of B cells and their interaction with the TNF pathway in HS pathogenesis, highlighting the potential of a novel nanobody targeting both OX40L and TNF (ClinicalTrials.gov NCT05849922) as a promising therapeutic approach. […] This suggests that inhibition of NET formation through a novel monoclonal antibody targeting citrullinated histones H2A and H4 (CIT-013) might yield promising results (13). […] These findings hold promise for a novel antiBAFF receptor antibody, ianalumab, currently under investigation (ClinicalTrials.gov NCT03827798). […] Interestingly, SYK inhibitors reduce fibrosis signatures in HS lesional skin (17), and a similar role for BTK inhibitors in attenuating fibrosis has been suggested (18). […] A recent study revealed that adding clindamycin and rifampicin to adalimumab treatment significantly increased the HiSCR response rate from 41% with adalimumab monotherapy to 86% with combined therapy and significantly reduced the draining tunnel count not captured in the HiSCR (22).

• #30

  https://www.jci.org/articles/view/186744

  Targeting a broader spectrum of immune responses, including T cells and B cell functions through JAK inhibition, might hold promise for a larger group of HS patients. Recent phase II trials demonstrated a positive trend toward increased clinical response to JAK1 inhibition compared with placebo (brepocitinib, 51.9% vs. 33.3%; povorcitinib, 48.1% vs. 28.8%: and upadacitinib, 38.3% vs. 23.8%) (32, 33, 34). […] Novel approaches targeting B cells and dual targets, including B and T cells, might offer the key to the long-sought highly effective treatment modality for HS, alone or in combination with current monoclonals targeting TNF or IL-17.

• #31 Association of Women in Rheumatology National Conference

  https://www.healio.com/news/rheumatology/20210814/hidradenitis-suppurativa-treatment-should-be-layered-address-psychosocial-impacts

  Providers should avoid monotherapy when treating hidradenitis suppurativa, and instead use a layered and rotated approach that also addresses the isolating psychosocial aspects of the disease, noted a speaker here. […] According to Okoye, the most important factor in treating HS is developing a multitiered approach that addresses the medical, surgical and psychosocial needs of the patient. […] I used to think of my treatment of HS like a pyramid or a ladder, where I would start with antimicrobials and work my way up through hormonal treatments and biologics, all the way to surgery, Okoye said. However, I now know that we really have to treat HS a little bit differently. We cant use monotherapy, so its no longer a stepwise fashion where we try one thing and then another. You have to layer therapies one on top of the other.

• #31 Association of Women in Rheumatology National Conference

  https://www.healio.com/news/rheumatology/20210814/hidradenitis-suppurativa-treatment-should-be-layered-address-psychosocial-impacts

  First-line treatment is generally antimicrobial therapy, which can be layered over other treatments, and can include antiseptic washes. […] According to Okoye, the mainstay of treatment for HS includes oral antibiotics, administered twice daily for 2-3 months. […] Biologics should be considered in patients with severe disease, those with an inadequate response to antibiotics, and those with comorbid Crohns disease, pyoderma gangrenosum or psoriasis. […] Again, medical management should be layered, and even rotated, otherwise youll hit a plateau and it tends to stop working, she added. In addition, surgical management is absolutely a part of the treatment algorithm here, so we can remove those sinus tracts and chronic lesions, to help prevent progression. […] Lastly, lifestyle modifications to help treat HS can include weight loss, nutritional counseling, referral for bariatric surgery if indicated, anti-inflammatory diet and smoking cessation.

• #32

  https://www.painscale.com/article/at-home-treatment-options-for-hidradenitis-suppurativa

  In addition to conventional medical treatments for hidradenitis suppurativa, several at-home treatments may also help prevent flare-ups, reduce symptoms, or prevent complications. These treatments include the following: […] Taking over-the-counter pain medications If HS lumps are painful, taking acetaminophen, ibuprofen or aspirin may help. Its important to note that a medical professional should always be consulted before taking any new medication. […] Keeping the area dry To reduce flare-ups, the affected area should be kept as dry as possible. Keeping the area dry can also prevent bacteria and fungus from growing, as they prefer moist locations. […] Using temperature therapy Applying heat to the affected area may help reduce pain. Warm, dry compresses, such as heating pads or gel packs, are the best choice. However, cold compresses can temporarily reduce pain and inflammation as well.

• #32

  https://www.painscale.com/article/at-home-treatment-options-for-hidradenitis-suppurativa

  Avoiding certain foods Avoiding foods and beverages that cause oxidative stress and contribute to inflammation may be beneficial for individuals with HS. Foods and beverages to avoid include sugary foods, processed meats, dairy products, fried foods, brewers yeast (commonly found in fermented foods and beverages, such as beer, wine, soy sauce, and some breads). […] Losing weight, if necessary Weight loss, if necessary, may help reduce symptoms of HS. […] Eliminating shaving of affected areas If HS affects areas of the body that are commonly shaved, the use of razor blades can make symptoms worse. A dermatologist can suggest gentler hair removal options. […] Gently cleansing the skin Cleansing with washcloths or loofahs should be avoided. Using clean hands to wash the area with non-soap cleanser or antiseptic wash is the best option. Freshly cleansed skin should be gently patted dry with a clean towel.

• #32

  https://www.painscale.com/article/at-home-treatment-options-for-hidradenitis-suppurativa

  Using mild or natural skincare and laundry products Using skincare and laundry products with added fragrances or dyes can irritate the skin. Using products that are free of irritants can help. Skincare products that will not clog pores and deodorant that does not contain aluminum may also help. […] Wearing loose-fitting clothes Tight-fitting clothes can rub against the skin and make HS worse. Wearing loose-fitting clothing made with natural fibers is best.

• #33 Understanding Your Hidradenitis Suppurativa Treatment Options

  https://ghlf.org/hidradenitis-suppurativa/understanding-your-hidradenitis-suppurativa-hs-treatment-options/

  For mild HS, topical antibiotics like clindamycin are often the first option. […] Oral antibiotics, such as doxycycline or clindamycin, may be prescribed for more severe cases. […] Three biologic medicines bimekizumab-bkzx, adalimumab, and secukinumab are FDA-approved specifically for treating moderate to severe HS. […] Biologics target specific parts of the immune system to reduce inflammation. […] Doctors may also combine biologics with other treatments, such as surgery or additional medications, to improve outcomes and reduce symptoms. […] Different treatments might help, depending on the seriousness of your condition. […] After surgery, wounds may heal naturally, be stitched closed, or require skin grafts for reconstruction. […] Managing pain in HS is a critical component of treatment. […] Maintaining a healthy weight and staying active is important to overall health and well-being. […] Quitting smoking is important for overall heart health and cardiovascular well-being.

• #33 Understanding Your Hidradenitis Suppurativa Treatment Options

  https://ghlf.org/hidradenitis-suppurativa/understanding-your-hidradenitis-suppurativa-hs-treatment-options/

  Managing HS can be challenging, but there are many treatment options to explore, including traditional medications, surgery, and holistic approaches like nutrition and lifestyle changes. […] Although hidradenitis suppurativa (HS) is not curable, creating the right treatment plan can help manage symptoms, prevent flare-ups, and reduce complications like tunneling or scarring. […] Your health care provider plays a key role in diagnosing HS and creating a treatment plan tailored to your needs. […] If side effects or challenges from a treatment are affecting your quality of life, speak with your doctor about other options that might work better. Advocating for your care is a key step in finding relief and managing HS effectively. […] From topical treatments to biologics, learning about the different treatments can help you and your doctor pick the best way to manage HS.

• #34 Hidradenitis Suppurativa (HS) Treatment Options

  https://www.healthline.com/health/hidradenitis-suppurativa/treatment

  Pain medications that might be used include: lidocaine (Ztlido), nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen (Tylenol), opioids, anticonvulsants. […] Corticosteroids are given via injection or in a pill form that works to decrease swelling, reduce inflammation, and manage pain. […] Because of the effect of hormones on HS, your doctor may recommend hormone therapy as a potential treatment option. […] Hormone therapy for HS could involve taking the following types of medications: oral contraceptives containing estrogen, spironolactone (Aldactone), finasteride (Propecia, Proscar). […] Oral retinoids are generally only recommended as a second- or third-line treatment for HS but can treat severe acne and HS lesions. […] For more severe cases of HS that dont respond to antibiotics or hormone therapy, biological drugs may be an option.

• #35 Hidradenitis Suppurativa (HS) Clinical Trials – Dermatology Treatment and Research Center

  https://www.dallasdermcenter.com/active-trials/hidradenitis-suppurativa-hs/

  Dermatology Treatment Research Center will soon be enrolling participants for a Hidradenitis Suppurativa (HS) clinical trial in Dallas, TX. Qualified participants will receive all study-related care provided by board-certified dermatologists at one of our partnered clinics. All Dermatology Treatment Research Center studies are in compliance with FDA guidelines and uphold the highest clinical standards. […] Our mission is to contribute meaningfully to the progress of dermatologic medicine by conducting rigorous research studies. We are continuously enrolling for a variety of studies, offering patients the opportunity to access emerging treatments and play a vital role in the development of new therapies. […] By integrating state-of-the-art technology and scientific expertise, we strive to improve patient outcomes and shape the future of dermatologic care.

• #36 Experts provide background and treatment for hidradenitis suppurativa: a chronic skin condition – UAB News

  https://www.uab.edu/news/news-you-can-use/experts-provide-background-and-treatment-for-hidradenitis-suppurativa-a-chronic-skin-condition

  If HS has caused the patient to develop depression or anxiety, dermatologists may also recommend counseling or support groups to help the patient feel supported as they navigate this condition. […] Clinical trials continue to offer new improved therapies for HS. […] Understanding cause of racial diversity and gender bias is the focus of investigation in our laboratory. Dr. Lin Jin is developing novel epigenetic approaches to ultimately discover personalized treatment for this disease. The diagnosis of disease in individual patients will be based on the identification of unique cell populations with unique gene signatures as the major driver of HS. Our approach is highly innovative and may be successful in the near future to find a highly effective treatment for these patients.

• #37 Hidradenitis Suppurativa Center

  https://www.umassmed.edu/hs-center/

  The immune system dysfunction underlying HS is poorly understood and its devastating effects on quality of life disproportionately affect women and minorities, highlighting a critical healthcare gap. […] Existing therapies for HS fail to consistently remit disease, thus there remains a great unmet need for better treatments. […] Dr. Whitley is co-director of the UMass Chan Hidradenitis Suppurativa Center. Her career goal is to accelerate development of more effective therapies for hidradenitis suppurativa (HS). […] She leads a team of researchers dedicated to developing and testing novel HS therapeutics.

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