Materiały źródłowe

• #1 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Lyme disease, also known as Lyme borreliosis, is an infectious condition transmitted through the bite of infected ticks, primarily caused by the spirochete bacterium Borrelia burgdorferi in the United States and various Borrelia species in Europe and Asia. This disease progresses through three stages: early localized, early disseminated, and late disease. Initial symptoms often include a characteristic „bull’s-eye” rash (erythema migrans), fever, and fatigue. If left untreated, the infection can advance to affect multiple systems, potentially leading to neurological symptoms, cardiac complications, and arthritis. The late stage may present with chronic arthritis and encephalopathy, underscoring the importance of early diagnosis and treatment. […] Lyme disease is divided into 3 stages: early localized, early disseminated, and late. Early localized disease is distinguished by the red ring-like expanding rash of erythema migrans at the site of a recent tick bite. Other symptoms experienced at this stage may be malaise, headache, fever, myalgia, and arthralgia. Most patients only experience the symptoms of early localized disease. About 20% of patients develop early disseminated disease, with the most common symptoms being multiple erythema migrans lesions.

• #1 Lyme disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lyme-disease/symptoms-causes/syc-20374651

  A tick bite may look like as a tiny, itchy bump on your skin, much like a mosquito bite. This doesn’t mean you have a tick-borne disease. Many people will not notice they’ve had a tick bite. […] The symptoms of Lyme disease vary. They usually show up in stages. But the stages can overlap. And some people don’t have symptoms of the typical early stage. […] Early symptoms of Lyme disease usually happen within 3 to 30 days after a tick bite. This stage of disease has a limited set of symptoms. This is called early localized disease. […] A rash is a common sign of Lyme disease. But it doesn’t always happen. The rash is usually a single circle that slowly spreads from the site of the tick bite. It may become clear in the center and look like a target or bull’s-eye. The rash often feels warm to the touch, But it’s usually not painful or itchy.

• #1 Signs and Symptoms of Untreated Lyme Disease | Lyme Disease | CDC

  https://www.cdc.gov/lyme/signs-symptoms/index.html

  Untreated Lyme disease can produce a wide range of symptoms, depending on the stage of infection. These include fever, rash, facial paralysis, an irregular heartbeat, and arthritis. […] Fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes may occur in the absence of rash. […] Erythema migrans (EM) rash occurs in approximately 70 to 80 percent of infected people. […] Begins at the site of a tick bite after a delay of 3 to 30 days (average is about 7 days). […] Expands gradually over several days reaching up to 12 inches (30 cm) or more across. […] May feel warm to the touch but is rarely itchy or painful. […] Sometimes clears as it enlarges, resulting in a target or „bull’s-eye” appearance. […] Severe headaches and neck stiffness. […] Additional EM rashes on other areas of the body.

• #1 Signs and Symptoms | Lyme Disease

  https://www.columbia-lyme.org/signs-and-symptoms

  Oblong rash associated with Lyme. […] A „sign” in medicine is something that can be confirmed by an outside observer. […] These would include such manifestations of Lyme disease as a swollen joint, a facial palsy, a Lyme rash. […] A „symptom” refers to a manifestation that can’t be confirmed by an outside observer; the physician has to rely on the patient’s report of the experience such as pain or fatigue or brain fog. […] Some doctors make the error of only relying on „signs” and not taking into account the range of „symptoms” that together form a pattern that is typical for Lyme disease. […] For example, studies have shown that about 20% of patients with new onset Lyme disease only present with fatigue, muscle and joint pain, headache and malaise. […] While the erythema migrans (EM) rash is the most common presentation of Lyme disease, it may not be seen in 20 to 30 percent of cases.

• #1 Lyme disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lyme-disease/symptoms-causes/syc-20374651

  Other stage 1 symptoms include: Fever. Headache. Extreme tiredness. Joint stiffness. Muscle aches and pains. Swollen lymph nodes. […] Without treatment, Lyme disease can get worse. The symptoms often show up within 3 to 10 weeks after a tick bite. Stage 2 is often more serious and widespread. It is called early disseminated disease. […] Stage 2 may include the stage 1 symptoms and the following: Many rashes on other parts of the body. Neck pain or stiffness. Muscle weakness on one or both sides of the face. Immune-system activity in heart tissue that causes irregular heartbeats. Pain that starts from the back and hips and spreads to the legs. Pain, numbness or weakness in the hands or feet. Painful swelling in tissues of the eye or eyelid. Immune-system activity in eye nerves that causes pain or vision loss.

• #1 Lyme Disease Stages, Timeline, & Progression

  https://www.globallymealliance.org/about-lyme/diagnosis/stages/

  Early disseminated Lyme may occur several weeks or months after the black-legged tick bite. The bacterium Borrelia burgdorferi is beginning to spread throughout the body. In addition to flu-like symptoms, this stage is often characterized by an increase in typical symptoms such as: chills, fever, headaches, fatigue, pain, weakness or numbness in the arms, legs, vision changes, Lyme carditis, heart problems, such as palpitations, chest pain, rash may appear on body, facial paralysis (Bells palsy). […] If Lyme disease isnt promptly or effectively treated in the first two stages, late disseminated (post-treatment, chronic, or neurological) Lyme occurs weeks, months, or even years after the infected tick bite. The bacterial infection has spread throughout the body and nervous system, and many untreated patients develop chronic Lyme arthritis as well as an increase in neurological and cardiac symptoms. In later stages of infection, more severe Lyme disease symptoms may include: arthritis in large joints or near the point of infection, severe headaches or migraines, vertigo, dizziness, migrating pains that come and go in joints/tendons, stiff, aching neck, chronic fatigue syndrome, sleep disturbances, insomnia, disturbances in heart rhythm, mental fogginess, concentration issues, numbness in the arms, legs, hands or feet, problems following conversations and processing information, severe fatigue.

• #1 Signs and Symptoms | Lyme Disease

  https://www.columbia-lyme.org/signs-and-symptoms

  When it does occur, it will develop at the site of the bite, usually within days to weeks. […] While most people know that a „target” or „bull’s eye” appearance is classic for Lyme disease, many are unaware that the Bull’s Eye is not the most common manifestation of the Lyme rash; in fact, only about 10-20% of EM rashes have this target appearance. […] The most typical appearance is a solid red or pink rash that starts small and expands to over 2 inches in size. […] Lyme meningitis symptoms consist of headache, neck stiffness, nausea, vomiting, light sensitivity and/or fever. […] Specifically, meningitis is the inflammation of the membranes covering the brain and spinal cord. […] Patients with encephalitis may present with sleepiness, abnormal mood swings, confusion, cognitive changes, personality or behavior changes, hallucinations, or seizures.

• #1 Lyme disease – Wikipedia

  https://en.wikipedia.org/wiki/Lyme_disease

  In about 4-10% of untreated cases in the United States, typically between June and December, about one month after the tick bite, the infection may cause heart complications known as Lyme carditis. Symptoms may include heart palpitations, dizziness, fainting, shortness of breath, and chest pain. Other symptoms of Lyme disease may also be present, such as EM rash, joint aches, facial palsy, headaches, or radicular pain. In some people, however, carditis may be the first manifestation of Lyme disease. […] Lyme arthritis occurs in up to 60% of untreated people, typically starting about six months after infection. It usually affects only one or a few joints, often a knee or possibly the hip, other large joints, or the temporomandibular joint. Usually, large joint effusion and swelling occur, but only mild or moderate pain. Without treatment, swelling and pain typically resolve over time, but periodically return.

• #1 Lyme disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lyme-disease/symptoms-causes/syc-20374651

  In the third stage, you may have symptoms from the earlier stages and other symptoms. This stage is called late disseminated disease. […] In the United States, the most common condition of this stage is arthritis in large joints, particularly the knees. Pain, swelling or stiffness may last for a long time. Or the symptoms may come and go. Stage 3 symptoms usually begin 2 to 12 months after a tick bite. […] The type of Lyme disease common in Europe can cause a skin condition called acrodermatitis chronic atrophicans. The skin on the backs of the hands and tops of the feet get discolored and swell. It also may show up over the elbows and knees. More-serious cases may cause damage to tissues or joints. […] This skin condition may show up many months to many years after a tick bite.

• #1 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Lyme arthritis tends to affect large joints, especially the knee. Symptoms manifest as joint pain with swelling and stiffness. Smaller joints, such as the elbow, may be involved, and episodes of bursitis or tendinitis may occur. Over time, in most cases, symptoms tend to subside even without intervention. In a small proportion of patients with Lyme arthritis, chronic inflammatory arthritis similar to rheumatoid arthritis may develop. This complication of Lyme disease is termed postinfectious Lyme arthritis.

• #1 Chronic Symptoms and Lyme Disease | Lyme Disease | CDC

  https://www.cdc.gov/lyme/signs-symptoms/chronic-symptoms-and-lyme-disease.html

  Following antibiotic treatment, some people with Lyme disease have prolonged symptoms of fatigue, body aches, or difficulty thinking as a result of their infection. […] Although most people recover completely when treated with a 2- to 4-week course of oral antibiotics, some can have prolonged symptoms of fatigue, body aches, or difficulty thinking. […] Studies published in the American Journal of Medicine (2010) and The Lancet Regional Health-Europe (2021) found that 6 months after treatment these symptoms are 5-10% more common among people who have had Lyme disease than among people who have not. […] If you have been treated for Lyme disease with a recommended regimen of antibiotics and continue to experience prolonged or recurring symptoms, it is important to work with your healthcare provider to evaluate all possible causes of your symptoms.

• #1 Lyme disease – Wikipedia

  https://en.wikipedia.org/wiki/Lyme_disease

  Chronic symptoms like pain, fatigue, or cognitive impairment are experienced by 5-20% of people who contract Lyme disease, even after completing treatment. This is called Post-treatment Lyme disease syndrome, or PTLDS. The cause is unknown. Hypotheses include that a persistent, difficult-to-detect infection remains, that autoimmunity has been triggered by the infection, that debris from a previous infection could remain, or that symptoms are simply unrelated to a Lyme infection. […] People who receive recommended antibiotic treatment within several days of the appearance of an initial EM rash have the best prospects. Recovery may not be total or immediate. The percentage of people achieving full recovery in the United States increases from about 64-71% at the end of treatment for EM rash to about 84-90% after 30 months; higher percentages are reported in Europe. Treatment failure, i.e., persistence of original or appearance of new signs of the disease, occurs only in a few people. Remaining people are considered cured but continue to experience subjective symptoms, e.g., joint or muscle pains or fatigue. These symptoms are usually mild and nondisabling.

• #1 Chronic Symptoms and Lyme Disease | Lyme Disease | CDC

  https://www.cdc.gov/lyme/signs-symptoms/chronic-symptoms-and-lyme-disease.html

  Patients with prolonged symptoms due to Lyme disease usually get better over time without additional antibiotics, but it can take many months to feel completely well. […] Careful studies conducted over the last two decades in the United States and Europe have generally found that extended treatment with antibiotics is no better than placebo for curing prolonged symptoms. […] The condition where patients experience prolonged symptoms due to Lyme disease is called Post-Treatment Lyme Disease Syndrome (PTLDS) and its cause is currently unknown. […] Regardless of the term used, prolonged symptoms can have devastating effects on a person’s life.

• #1 Lyme Disease Signs Symptoms

  https://portal.ct.gov/DPH/Epidemiology-and-Emerging-Infections/Lyme-Disease-Signs–Symptoms

  Many symptoms are associated with Lyme disease. It is known as the great masquerader because its symptoms mimic so many other diseases and conditions. Lyme disease should be considered when a person has a history of being in a tick infested area or has knowledge of tick bites. […] Early signs and symptoms of Lyme disease infection include: An expanding red rash, Flu-like symptoms that include: muscle aches, fatigue, and fever. These symptoms generally appear 2-32 days after the bite of an infected deer tick. Some people who are bitten by an infected deer tick do not develop early symptoms of Lyme disease and this makes it difficult to get early treatment. Left untreated the infection may spread to other parts of the body. […] Early disseminated disease symptoms may resolve on their own after a few weeks to months and include: Rashes on other parts of the body, Facial or Bell’s palsy, Meningitis, Pain and swelling in large joints, Heart palpitations, Dizziness.

• #1 Unusual symptoms of Lyme disease: Types and complications

  https://www.medicalnewstoday.com/articles/unusual-symptoms-of-lyme-disease

  Many people associate Lyme disease with a classic rash that resembles a bulls-eye. Less common symptoms include aches and pains as well as neurological symptoms, such as changes in vision and hearing. […] Lyme disease can produce different symptoms and signs in its early stages. […] According to the Centers for Disease Control and Prevention (CDC), some common early signs of Lyme disease include fatigue, fever, swollen lymph nodes, chills, headache, joint and muscle aches. […] Many people associate Lyme disease with an erythema migrans rash, which resembles a bulls-eye or target. However, the CDC notes that a rash may not occur in 20-30% of all Lyme disease cases. […] Below are some less common symptoms that a person with Lyme disease may experience. […] Lyme disease can cause arthritis-like pain in the joints in its early stages. The difference between Lyme disease and arthritis is that Lyme disease affects one joint for a short amount of time and then moves to another joint.

• #1 Adolescents and Lyme diseas

  https://danielcameronmd.com/adolescent-lyme-disease/

  The statistics surrounding children and Lyme disease are alarming. […] The incidence of Lyme disease in children is growing despite efforts for greater awareness and prevention. […] The disease can be difficult to recognize in children. […] Typically, the majority of children and adolescents suffering with Lyme disease will complain of unrelenting fatigue, an inability to engage in activities they once enjoyed and experience a decline in school performance. […] The most common symptoms include gastrointestinal problems, headaches, fatigue, sleep disturbances, joint and muscle pain, poor concentration, inability to focus, mood swings, sudden behavioral changes, vocal and/or motor tics, light and/or sound sensitivity, and new onset of anxiety disorders. […] The number of reported Lyme disease cases, occurring annually, has more than tripled over the past 10 years, with children most at risk for the disease, according to the Centers for Disease Control and Prevention (CDC). […] Misdiagnosis of Lyme disease is common. […] Unfortunately, there has been minimal research conducted, despite the high risk and high rate of infection among children and adolescents. The long-term treatment outcomes in children need to be studied.

• #1 Lyme disease symptoms checklist test. Do you have Lyme disease?

  https://www.lymedisease.org/lyme-disease-symptom-checklist/

  Many people with Lyme disease are misdiagnosed. Early diagnosis and treatment are essential to restore patients to health and to prevent progression of the disease to late or chronic Lyme disease, which is much harder to treat. Lyme disease is a clinical diagnosis based on the patients medical history, symptoms and exposure to ticks. Only 25-30% of patients with Lyme disease remember a tick bite. A distinctive rash shaped like a bulls-eye is considered characteristic of Lyme disease. Yet, this type of rash only occurs in 9% of patients. Only half of the patients with chronic Lyme disease recall having early symptoms. Symptoms are often dismissed by patients because they do not recall a tick bite or believe they have the flu. New onset fatigue, widespread pain, sleep disturbance, and cognitive impairment are common symptoms of late Lyme disease. Many symptoms of late or chronic Lyme disease are non-specific and common among diseases. What sets Lyme patients apart is the severity of symptoms and the degree of functional impairment. Most patients with chronic Lyme disease report one or more of the following symptoms as severe or very severe: fatigue (48%), sleep impairment (41%), joint pain (39%), muscle aches (36%), other pain (34%), depression (34%), cognitive impairment (32%), neuropathy (32%), headaches (23%) and heart-related issues (10%). Delay in diagnosis is common. Approximately 60% of patients with chronic Lyme disease are not diagnosed for at least 2 years. Roughly 50% of negative Lyme tests are false negatives.

• #1 Lyme Disease Stages and Symptoms

  https://www.lyme.health.harvard.edu/stages-and-symptoms/

  Learning about Lyme disease stages can help you know what symptoms you might experience and can help you watch for signs that could mean that your Lyme disease has progressed. […] If you have already been diagnosed with Lyme disease, learning about Lyme disease stages can help you know what symptoms you might experience. You’ll also be able to watch for signs that could mean that your Lyme disease has progressed. Lyme disease symptoms are more likely to progress if you have not been appropriately treated. […] There are three stages of Lyme disease. Early localized, or Stage 1, Lyme disease occurs soon after being infected, when the Lyme disease bacteria are still close to the site of the tick bite. Common symptoms of early localized Lyme disease include a rash or mild, flulike symptoms. Over time the Lyme disease bacteria can spread, or disseminate, to other parts of the body, causing more serious symptoms associated with early disseminated (Stage 2) or late disseminated (Stage 3) Lyme disease. This is more likely if you are not diagnosed and treated early.

• #1 Lyme disease – Wikipedia

  https://en.wikipedia.org/wiki/Lyme_disease

  The Lyme rash is often accompanied by symptoms of a flu-like illness, including fatigue, headache, body aches, fever, and chills. These symptoms may also appear without a rash or linger after the rash has disappeared. Lyme can progress to later stages without a rash or these symptoms. […] Within days to weeks after the onset of local infection, the Borrelia bacteria may spread through the lymphatic system or bloodstream. In 10-20% of untreated cases, EM rashes develop at sites across the body that bear no relation to the original tick bite. Transient muscle pains and joint pains are also common. […] In about 10-15% of untreated people, Lyme causes neurological problems known as neuroborreliosis. Early neuroborreliosis typically appears 4-6 weeks after the tick bite and involves some combination of lymphocytic meningitis, cranial neuritis, radiculopathy, and/or mononeuritis multiplex. In North America, facial palsy is the typical early neuroborreliosis presentation, occurring in 5-10% of untreated people, in about 75% of cases accompanied by lymphocytic meningitis. Lyme radiculopathy is reported half as frequently, but many cases may be unrecognized.

• #1 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Early disseminated disease is associated with neurologic and cardiac manifestations. Neurologic Lyme disease manifestations include facial nerve (cranial nerve VII) palsy, lymphocytic meningitis, or radiculopathy. Cardiac involvement may consist of myopericarditis and heart block. Lyme arthritis is typically a late disease manifestation and may be monoarticular or pauciarticular, generally involving large joints, most commonly the knee, and occurring months after the initial tick bite. […] Late-stage Lyme disease may occur months after the initial infection. The typical features include neurological and musculoskeletal involvement. Many patients may not have a history of erythema migrans. However, these individuals may present with sensory axonal polyneuropathy, encephalomyelitis, or mononeuropathy. Cognitive deficits are common. Encephalopathy presents with deficits in concentration, cognition, memory loss, and personality changes. Extreme irritability and depression are also common. Encephalomyelitis is rare and can present with ataxia, seizures, hemiparesis, autonomic dysfunction, and hearing loss.

• #1 Lyme disease: clinical diagnosis and treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5864449/

  Neuroborreliosis has a clinical spectrum that can include meningitis, facial paralysis, motor or sensory radiculopathy, and cognitive symptoms. […] If left untreated, Lyme disease can evolve into late disease, which presents with persistent arthritis and/or persistent neuroborreliosis. […] In North America, up to 60% of untreated Lyme disease cases show monoarticular or oligoarticular arthritis, usually involving the knees, with other joints such as the ankle, elbow and wrist less commonly affected. […] Up to 10% of patients will have evidence of synovitis six months after treatment for Lyme arthritis, termed antibiotic refractory Lyme arthritis. […] The most common manifestation of neuroborreliosis in North America is subacute encephalopathy with subtle cognitive changes. […] It is clear that a proportion of patients with confirmed evidence of previous Lyme disease continue to have symptoms after standard antimicrobial treatment. […] Persistent symptoms include fatigue, generalized musculoskeletal pain and cognitive impairment without objective findings or microbiological evidence of active infection.

• #1 Lyme Disease: MedlinePlus

  https://medlineplus.gov/lymedisease.html

  If the infection is not treated, it can spread to your joints, heart, and nervous system. The symptoms may include: Severe headaches and neck stiffness. More EM rashes on other areas of your body. Facial palsy, which is a weakness in your facial muscles. It can cause drooping on one or both sides of your face. Arthritis with severe joint pain and swelling, especially in your knees and other large joints. Pain that comes and goes in your tendons, muscles, joints, and bones. Heart palpitations, which are feelings that your heart is skipping a beat, fluttering, pounding, or beating too hard or too fast. An irregular heart beat (Lyme carditis). Episodes of dizziness or shortness of breath. Inflammation of the brain and spinal cord. Nerve pain. Shooting pains, numbness, or tingling in the hands or feet.

• #1 Lyme disease: Symptoms and treatment – Canada.ca

  https://www.canada.ca/en/public-health/services/diseases/lyme-disease.html

  Other later stage symptoms include: nerve pain, weakness, tingling or loss of sensation in limbs, drooping of one or both sides of the face (facial paralysis or Bell’s palsy), heart palpitations and an abnormal heartbeat, swelling of the brain and spinal cord, eye problems, such as conjunctivitis (pink-eye). […] In very rare cases, death could occur due to the complications involving an infection of the heart. […] Early diagnosis and treatment of Lyme disease can prevent complications. […] Diagnosing Lyme disease can be challenging as symptoms vary from person to person. […] Symptoms of Lyme disease can be similar to other illnesses. […] Lyme disease is treated with antibiotics. The earlier you receive treatment for Lyme disease, the greater the chance of a successful recovery. […] Some people who are treated for Lyme disease may continue to have symptoms after treatment. The cause of these symptoms isn’t currently clear.

• #1 Symptoms of Lyme Disease | Acute to Chronic Lyme Disease Symptoms List

  https://www.globallymealliance.org/about-lyme/diagnosis/symptoms/

  Lyme disease symptoms are wide-ranging, with more than a hundred different symptoms recorded. Symptoms can also change over time, as the bacteria spreads throughout the body. To make things more confusing, Lyme disease symptoms will also vary from patient-to-patient. […] Symptoms can play a key role in diagnosing Lyme disease. Due to the lack of an accurate diagnostic test, many patients are diagnosed based on a combination of symptoms and diagnostic testing. This makes it extremely important for patients to keep track of all the symptoms they experience, to share with their healthcare provider. […] Lyme disease symptoms can vary based on stage of the disease (early, late, post-treatment, or chronic) and if other tick-borne infections are present and can change over time. […] The most common symptoms in acute (aka: early localized) Lyme disease are the ones people are most familiar with, because they are symptoms often shared with other illnesses; however, its important to recognize that they could indicate Lyme, and you should see a Lyme-treating physician right away.

• #1 Lyme Disease: Symptoms, Signs, Treatment, and More

  https://www.healthline.com/health/lyme-disease

  Stages 2 and 3 of Lyme disease are characterized by systemic infection. This means the infection has spread throughout your body, including to other organs. […] Symptoms may include: abnormal heart rhythm, which can be caused by Lyme carditis, neurologic conditions, such as facial palsies and cranial neuropathy, multiple erythema migrans lesions on your body, numbness, tingling, and pain in your hands and feet, severe headaches, neck stiffness, meningitis, arthritis of one or more large joints, typically the knee, encephalopathy, which may cause short-term memory loss, difficulty concentrating, mental fogginess, problems with following conversations, and sleep disturbance. […] Its important to note that you may experience later symptoms of Lyme disease without experiencing earlier symptoms, such as a bulls eye rash.

• #1 Lyme Disease Symptoms | LymeDisease.org

  https://www.lymedisease.org/lyme-basics/lyme-disease/symptoms/

  In our survey, which drew over 5,000 responses, patients with chronic Lyme disease reported an average of three severe or very severe symptoms, with 74% reporting at least one symptom as severe or very severe. […] Many Lyme symptoms, such as fatigue, cognitive impairment, joint pain, poor sleep, mood problems, muscle pain, and neurological presentations also occur in other diseases. […] Hence, the symptoms of Lyme disease significantly overlap those of chronic fatigue, fibromyalgia, rheumatoid arthritis, multiple sclerosis, Parkinsons disease, ALS, depression and Alzheimers disease. […] Many Lyme patients report being misdiagnosed with a different condition before being properly diagnosed with Lyme disease.

• #1 About Lyme Disease – MN Dept. of Health

  https://www.health.state.mn.us/diseases/lyme/basics.html

  Early recognition of signs and symptoms of Lyme disease is very important for prompt diagnosis and treatment. […] Early diagnosis and treatment can reduce the time a person is ill and the severity of the disease. […] Treatment is most effective early in the course of Lyme disease. Lyme disease detected later is also treatable with antibiotics, but can cause symptoms that may take longer to go away, even after the antibiotics have killed the Lyme disease bacteria. […] Most people have a complete resolution of their symptoms after treatment. A small percentage of patients (especially those diagnosed in the later stages of the disease) have persistent complaints after treatment.

• #1 4 steps to care for patients with prolonged symptoms of Lyme disease | American Medical Association

  https://www.ama-assn.org/delivering-care/public-health/4-steps-care-patients-prolonged-symptoms-lyme-disease

  Lyme disease is treatable with a 10 day to four-week course of antibiotics. However, about 5% to 10% of patients experience symptoms of fatigue, body aches or difficulty thinking for six months or longer after treatment, over and above the rate of these symptoms in the general population, said Dr. Marx. […] When evaluating a patient with prolonged symptoms and concerns about Lyme disease, it’s critical to take a holistic approach that centers on listening to and validating the patient’s experience and thoroughly exploring a broad differential diagnosis. […] Failure to diagnose Lyme disease early can lead to delayed treatment and dissemination of disease, which increases risk of prolonged symptoms even after effective treatment.

• #1 Lyme Disease | Mass.gov

  https://www.mass.gov/info-details/lyme-disease

  About 60% of people with untreated Lyme disease get arthritis in their knees, elbows and/or wrists. The arthritis can move from joint to joint and become chronic. […] Many people who don’t get treatment develop nervous system problems. These problems include meningitis (an inflammation of the membranes covering the brain and spinal cord), facial weakness (Bell’s palsy) or other problems with nerves of the head, and weakness or pain (or both) in the hands, arms, feet and/or legs. These symptoms can last for months, often shifting between mild and severe. […] The heart also can be affected in Lyme disease, with slowing down of the heart rate and fainting. The effect on the heart can be early or late.

• #1 Lyme Disease | Chester County, PA – Official WebsiteArrow LeftArrow RightSlideshow Left ArrowSlideshow Right Arrow

  https://www.chesco.org/848/Lyme-Disease

  Months/years after bite: Approximately 60% of patients who go untreated may begin to have bouts of arthritis, with severe joint pain and swelling. Large joints are most often affected, particularly the knees. Up to 5% of untreated patients may develop chronic neurological complaints months to years after infection. These include shooting pains, numbness or tingling in the hands or feet, and problems with short-term memory. […] Lingering symptoms after treatment: Approximately 10-20% of patients with Lyme disease have symptoms that last months to years after treatment with antibiotics. These symptoms can include muscle and joint pains, cognitive defects, sleep disturbance, or fatigue. The cause of these symptoms is not known, but there is no evidence that these symptoms are due to ongoing infection from Lyme disease. This condition is referred to as Post-treatment Lyme disease syndrome (PTLDS).

• #1 Lyme Disease Stages: How Untreated Lyme Disease Progresses

  https://www.verywellhealth.com/lyme-disease-stages-5176671

  Various neurological symptoms can occur depending on the area of the nervous system affected. Some symptoms may be similar to stage 2 but can be more extensive, severe, or longer-lasting. If the infection has traveled to the brain, you may experience: Difficulty following conversations and processing information, Mental fogginess, Trouble sleeping, Vertigo or dizziness. […] Oral antibiotics are typically used for Lyme arthritis, while intravenous antibiotics treat neurologic issues. The length of therapy can be two to four weeks, depending on the symptoms. […] Early detection and treatment of Lyme disease may prevent the infection from progressing to later stages of the illness. […] Be sure to contact your doctor if you are experiencing any of the previously discussed symptoms (even if you don’t have a rash) including flu-like symptoms, muscle or joint pain, or fatigue.

• #1 Lyme Disease: Symptoms, Signs, Treatment, and More

  https://www.healthline.com/health/lyme-disease

  Lyme disease results from the bite of an infected tick. It can cause many symptoms, including a bulls-eye rash and joint pain, and may result in post-Lyme disease syndrome. […] Symptoms of Lyme disease vary depending on the stage of infection. […] For example, symptoms of stages 1 and 2 may overlap. Or, you may not experience any stage 1 symptoms but experience later symptoms. […] One of the earliest signs of the disease is a bulls-eye rash, also known as an erythema migrans. […] Other symptoms commonly seen in stage 1 of Lyme disease include: chills, fever, enlarged lymph nodes, sore throat, vision changes, fatigue, muscle aches, headaches. […] Early disseminated Lyme disease can appear up to 3 months after the tick bite, while late disseminated Lyme disease may take up to 12 months.

• #2 Lyme Disease Stages, Timeline, & Progression

  https://www.globallymealliance.org/about-lyme/diagnosis/stages/

  Lyme disease occurs in three stages: early localized, early disseminated, and late disseminated. […] A bulls-eye rash is usually considered one of the first signs of infection, but many people develop a different kind of rash or none at all. In most cases, Lyme symptoms can start with a flu-like illness. Untreated Lyme disease symptoms can continue to worsen and turn into a long-lived debilitating illness affecting the neurological, cardiac, and immune systems of patients. Understanding the progression of Lyme disease and its potential complications is crucial in order to emphasize the importance of early detection and treatment. […] Early symptoms with localized (or acute) Lyme disease may begin hours, a few days, or even weeks after a deer tick bite. […] Early Stage Symptoms may include: Erythema Migrans skin rash (EM rash), which may or may not look like a bulls eye, flu-like illness, including chills and fever, fatigue, headache and stiff neck, muscle soreness and joint pain, swollen lymph nodes, sore throat.

• #2 Lyme disease Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/lyme-disease

  Untreated Lyme disease has three stages: early localized stage, early disseminated stage, and late stage. […] A red rash appears within a few days or weeks of a tick bite. It starts as a small red spot at the site of the bite. The spot gets bigger over time, making a flat or slightly raised circle or oval that sometimes looks like a bull’s eye with the bite make at the center. The rash can range in size from that of a dime to the entire width of a person’s back. As the infection spreads, rashes can show up at different places on the body. Flu-like symptoms like headache, fatigue, and fever may also appear. […] Without treatment, the disease can spread through the blood or lymph to different organs of the body. This stage develops weeks to months after the tick bite. Symptoms includes: Rashes in different parts of the body, Severe fatigue, Nerve pain or numbness, If the heart is affected: heart problems, such as palpitations, fainting, chest pain, and shortness of breath. Neurological symptoms, such as a stiff neck and severe headache (may indicate meningitis), temporary paralysis of muscles in the face (Bell’s palsy), numbness, pain or weakness in the limbs, or poor motor coordination.

• #2 Lyme Disease: MedlinePlus

  https://medlineplus.gov/lymedisease.html

  Lyme disease is a bacterial infection you get from the bite of an infected tick. At first, Lyme disease usually causes symptoms such as a rash, fever, headache, and fatigue. But if it is not treated early, the infection can spread to your joints, heart, and nervous system. Prompt treatment can help you recover quickly. […] Early symptoms of Lyme disease start between 3 to 30 days after an infected tick bites you. The symptoms can include: A red rash called erythema migrans (EM). Most people with Lyme disease get this rash. It gets bigger over several days and may feel warm. It is usually not painful or itchy. As it starts to get better, parts of it may fade. Sometimes this makes the rash look like a „bull’s-eye.” Fever, Chills, Headache, Fatigue, Muscle and joint aches, Swollen lymph nodes („swollen glands”).

• #2 Lyme Disease Symptoms : Johns Hopkins Lyme Disease Research Center

  https://www.hopkinslyme.org/lyme-disease/lyme-disease-signs-symptoms/

  In the first early localized stage of Lyme disease the skin at the site of the tick bite becomes infected with Borrelia burgdorferi bacteria. The initial infection can cause an expanding round or oval red skin lesion called erythema migrans and associated flu-like symptoms within days to a month after the tick bite. Early symptoms can include achiness, chills, fever, sweats, fatigue, malaise, headache, stiff neck, muscle soreness, joint pain, swollen lymph nodes, and sore throat. The combination of the skin lesion and flu-like symptoms are the primary manifestations of acute stage Lyme disease, although the rash and flu-like symptoms are not always present. […] The symptoms of second stage, early disseminated, Lyme disease can be difficult to attribute. Symptoms include severe fatigue, fever, pain, intermittent weakness and achiness of the muscles and joints, numbness in arms and legs, vision changes, and cognitive dysfunction such as short-term memory difficulties and problems multitasking. These symptoms are not specific for Lyme disease and can make the diagnosis of second stage Lyme disease very challenging.

• #2 Unusual symptoms of Lyme disease: Types and complications

  https://www.medicalnewstoday.com/articles/unusual-symptoms-of-lyme-disease

  Many people associate Lyme disease with a classic rash that resembles a bulls-eye. Less common symptoms include aches and pains as well as neurological symptoms, such as changes in vision and hearing. […] Lyme disease can produce different symptoms and signs in its early stages. […] According to the Centers for Disease Control and Prevention (CDC), some common early signs of Lyme disease include fatigue, fever, swollen lymph nodes, chills, headache, joint and muscle aches. […] Many people associate Lyme disease with an erythema migrans rash, which resembles a bulls-eye or target. However, the CDC notes that a rash may not occur in 20-30% of all Lyme disease cases. […] Below are some less common symptoms that a person with Lyme disease may experience. […] Lyme disease can cause arthritis-like pain in the joints in its early stages. The difference between Lyme disease and arthritis is that Lyme disease affects one joint for a short amount of time and then moves to another joint.

• #2 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Other symptoms of the disseminated stage are flu-like symptoms, lymphadenopathy, arthralgia, myalgia, palsies of the cranial nerves, especially of cranial nerve VII, ophthalmic conditions, and lymphocytic meningitis. Additionally, cardiac manifestations, including conduction abnormalities, myocarditis, or pericarditis, may occur. The most common late-stage manifestation is arthritis, which is usually pauciarticular and affects large joints, especially the knees. […] Lyme disease is classified into 3 stages: early localized, early disseminated, and late. Approximately 1.6% to 7% of individuals may have an asymptomatic Lyme infection. In most cases, however, patients develop symptoms of Lyme disease, with erythema migrans being the most common initial manifestation. Erythema migrans is characteristic of early localized disease, occurring 1 to 2 weeks after a tick bite. Patients may develop early disseminated or late disease if the infection persists or goes untreated.

• #2 Lyme Disease: MedlinePlus

  https://medlineplus.gov/lymedisease.html

  If the infection is not treated, it can spread to your joints, heart, and nervous system. The symptoms may include: Severe headaches and neck stiffness. More EM rashes on other areas of your body. Facial palsy, which is a weakness in your facial muscles. It can cause drooping on one or both sides of your face. Arthritis with severe joint pain and swelling, especially in your knees and other large joints. Pain that comes and goes in your tendons, muscles, joints, and bones. Heart palpitations, which are feelings that your heart is skipping a beat, fluttering, pounding, or beating too hard or too fast. An irregular heart beat (Lyme carditis). Episodes of dizziness or shortness of breath. Inflammation of the brain and spinal cord. Nerve pain. Shooting pains, numbness, or tingling in the hands or feet.

• #2 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Early disseminated disease is associated with neurologic and cardiac manifestations. Neurologic Lyme disease manifestations include facial nerve (cranial nerve VII) palsy, lymphocytic meningitis, or radiculopathy. Cardiac involvement may consist of myopericarditis and heart block. Lyme arthritis is typically a late disease manifestation and may be monoarticular or pauciarticular, generally involving large joints, most commonly the knee, and occurring months after the initial tick bite. […] Late-stage Lyme disease may occur months after the initial infection. The typical features include neurological and musculoskeletal involvement. Many patients may not have a history of erythema migrans. However, these individuals may present with sensory axonal polyneuropathy, encephalomyelitis, or mononeuropathy. Cognitive deficits are common. Encephalopathy presents with deficits in concentration, cognition, memory loss, and personality changes. Extreme irritability and depression are also common. Encephalomyelitis is rare and can present with ataxia, seizures, hemiparesis, autonomic dysfunction, and hearing loss.

• #2 Stage 3 Lyme Disease Signs, Long Island

  https://longislandlymedisease.com/lyme-disease-signs-stage-3-long-island/

  Stage 3 Lyme Disease is called late disseminated Lyme disease and the bacteria has spread throughout the body. Stage 3 Lyme Disease Signs involves symptoms in various organs. Symptoms may include; arthritis of one or multiple large joints (usually the knee), confusion, short-term memory loss, inflammation of the heart, inflammation of tissue surrounding the brain, and numbness in the hands, legs and feet. For some patients, symptoms persist for months or years. […] Within a few weeks (up to 2 years) after the start of the infection, about 60% of people develop arthritis characterized by joint pain and swelling. In stage 3, you may have temporary periods of arthritis or you may feel the arthritis symptoms all the time. You may also have ongoing nervous system problems, but this is less likely.

• #2 Lyme disease – Wikipedia

  https://en.wikipedia.org/wiki/Lyme_disease

  In about 4-10% of untreated cases in the United States, typically between June and December, about one month after the tick bite, the infection may cause heart complications known as Lyme carditis. Symptoms may include heart palpitations, dizziness, fainting, shortness of breath, and chest pain. Other symptoms of Lyme disease may also be present, such as EM rash, joint aches, facial palsy, headaches, or radicular pain. In some people, however, carditis may be the first manifestation of Lyme disease. […] Lyme arthritis occurs in up to 60% of untreated people, typically starting about six months after infection. It usually affects only one or a few joints, often a knee or possibly the hip, other large joints, or the temporomandibular joint. Usually, large joint effusion and swelling occur, but only mild or moderate pain. Without treatment, swelling and pain typically resolve over time, but periodically return.

• #2 What Is Chronic Lyme Disease (Stage 3)? Symptoms & Signs

  https://www.medicinenet.com/what_are_the_stages_of_lyme_disease/article.htm

  If untreated, Lyme disease can progress to chronic Lyme disease or stage 3 of Lyme disease. Stage 3 Lyme disease occurs months to years after the initial infection or during a period of latency. Most patients presenting with the late disease do not have erythema migrans because the rash urges the patient to seek treatment earlier. […] Stage 3 Lyme disease symptoms include skin manifestation (acrodermatitis chronica atrophicans), Lyme arthritis, and nervous system abnormalities. […] Symptoms of Stage 3 Lyme Disease may include the following: Skin manifestation: Acrodermatitis Chronica atrophicans: found almost exclusively in patients of European descent. It commonly affects older women with bluish-red discoloration on the back of the hands, feet, knees, and elbows. Lyme arthritis: typically involves one or a few large joints (the knee is involved in 90% of cases). severe inflammation and joint pain. Nervous system abnormalities: encephalopathy, encephalomyelitis (inflammation of the brain), neuropathy nerve paralysis, acute spinal disk disease, hemiparesis (weakness of one side of the body), ataxia (loss of muscle coordination), seizures, bladder dysfunction (loss of urinary control), hearing loss, myelitis (inflammation of the spinal cord), paraparesis (paralysis of lower limbs), quadriparesis (paralysis of all limbs).

• #2 Lyme disease – Wikipedia

  https://en.wikipedia.org/wiki/Lyme_disease

  Chronic symptoms like pain, fatigue, or cognitive impairment are experienced by 5-20% of people who contract Lyme disease, even after completing treatment. This is called Post-treatment Lyme disease syndrome, or PTLDS. The cause is unknown. Hypotheses include that a persistent, difficult-to-detect infection remains, that autoimmunity has been triggered by the infection, that debris from a previous infection could remain, or that symptoms are simply unrelated to a Lyme infection. […] People who receive recommended antibiotic treatment within several days of the appearance of an initial EM rash have the best prospects. Recovery may not be total or immediate. The percentage of people achieving full recovery in the United States increases from about 64-71% at the end of treatment for EM rash to about 84-90% after 30 months; higher percentages are reported in Europe. Treatment failure, i.e., persistence of original or appearance of new signs of the disease, occurs only in a few people. Remaining people are considered cured but continue to experience subjective symptoms, e.g., joint or muscle pains or fatigue. These symptoms are usually mild and nondisabling.

• #2 Chronic (Persistent) Lyme Disease: Symptoms and Diagnosis

  https://www.healthline.com/health/lyme-disease-chronic-persistent

  Chronic Lyme disease occurs when a person whos treated with antibiotic therapy for the disease continues to experience symptoms. […] According to the New England Journal of Medicine, approximately 10 to 20 percent of people who are treated with the recommended antibiotics will have disease symptoms that persist after they complete treatment. These symptoms can include fatigue, joint or muscle aches, and cognitive dysfunction. […] Typically, the symptoms of post-treatment Lyme disease syndrome resemble those that occur in earlier stages. People with persistent symptoms often experience lingering episodes of: fatigue, restless sleep, pain, aching joints or muscles, pain or swelling in the knees, shoulders, elbows, and other large joints, decreased short-term memory or ability to concentrate, speech problems.

• #2 What more can be done to treat Lyme disease and its potential long-term effects | PBS News Weekend

  https://www.pbs.org/newshour/show/what-more-can-be-done-to-treat-lyme-disease-and-its-potential-long-term-effects

  Yeah, in 2015, my health completely unraveled after years of mysterious symptoms. I was living in New York City at the time, I was 26 years old, and I was losing my memory. I lost my ability to read, I was experiencing neurological pain, joint pain, it would migrate throughout my body. […] My mom actually tipped me off to the fact that I had had Lyme disease two years prior, received the short course of treatment. And it appears that I wasn’t actually cured, and my health just completely tanked at 26 years old. […] The notion of faulty diagnostics, that seems to be a very basic thing that you want to try to improve. […] That’s a step in the right direction, acknowledging that the Lyme bacteria can lead to chronic symptoms. But, you know, the scientific evidence does suggest that maybe not in all cases, but in some cases, it is a persistent infection, that these short courses of antibiotics that we’re expecting to cure humans are not curing mice or not curing monkeys, horses, dogs.

• #2 Chronic Symptoms and Lyme Disease | Lyme Disease | CDC

  https://www.cdc.gov/lyme/signs-symptoms/chronic-symptoms-and-lyme-disease.html

  Patients with prolonged symptoms due to Lyme disease usually get better over time without additional antibiotics, but it can take many months to feel completely well. […] Careful studies conducted over the last two decades in the United States and Europe have generally found that extended treatment with antibiotics is no better than placebo for curing prolonged symptoms. […] The condition where patients experience prolonged symptoms due to Lyme disease is called Post-Treatment Lyme Disease Syndrome (PTLDS) and its cause is currently unknown. […] Regardless of the term used, prolonged symptoms can have devastating effects on a person’s life.

• #2 Unusual symptoms of Lyme disease: Types and complications

  https://www.medicalnewstoday.com/articles/unusual-symptoms-of-lyme-disease

  In more advanced, untreated Lyme disease, joint pain can turn into intermittent arthritis. […] If the bacteria that causes Lyme disease moves into the central nervous system, it can cause sensory issues. This can include sensitivity to light as well as other visual disturbances. […] In some cases, Lyme disease can cause auditory (hearing) issues. […] Lyme disease can cause cognitive, neurological, and, in some cases, psychological symptoms. It can affect the central, cranial, and peripheral nervous systems. […] The symptoms can often resemble those of other disorders, which could lead to misdiagnosis. […] Left untreated, Lyme disease can affect several areas of the body, including the central nervous system and heart. […] Lyme carditis occurs when the bacteria enter the heart tissue. This causes disturbances in how electrical signals move throughout the heart, which can cause several symptoms, including heart palpitations, fainting, shortness of breath, chest pain, lightheadedness.

• #2 Lyme Disease Stages and Symptoms

  https://www.lyme.health.harvard.edu/stages-and-symptoms/

  Learning about Lyme disease stages can help you know what symptoms you might experience and can help you watch for signs that could mean that your Lyme disease has progressed. […] If you have already been diagnosed with Lyme disease, learning about Lyme disease stages can help you know what symptoms you might experience. You’ll also be able to watch for signs that could mean that your Lyme disease has progressed. Lyme disease symptoms are more likely to progress if you have not been appropriately treated. […] There are three stages of Lyme disease. Early localized, or Stage 1, Lyme disease occurs soon after being infected, when the Lyme disease bacteria are still close to the site of the tick bite. Common symptoms of early localized Lyme disease include a rash or mild, flulike symptoms. Over time the Lyme disease bacteria can spread, or disseminate, to other parts of the body, causing more serious symptoms associated with early disseminated (Stage 2) or late disseminated (Stage 3) Lyme disease. This is more likely if you are not diagnosed and treated early.

• #2 Lyme Disease Stages: How Untreated Lyme Disease Progresses

  https://www.verywellhealth.com/lyme-disease-stages-5176671

  People treated during this stage often recover quickly and completely. Treatment involves 10 to 14 days of oral antibiotics. […] Unfortunately, 10% to 25% of cases may go unnoticed and progress to later stages of the disease. […] If Lyme disease is left untreated, it may progress to early disseminated Lyme disease, which spreads from the bite location to other parts of the body. It may begin to affect the skin, nervous system, and heart. This stage can occur days to months following the initial infection. Neurologic symptoms occur in approximately 10% of untreated people. […] Inflammation of the nervous system can cause: Facial paralysis (drooping on one or both sides of the face), Fever, Numbness, tingling, shooting pain, or weakness in the arms or legs, Sensitivity to light, Severe headache or neck stiffness.

• #2 Lyme Disease – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/bacterial-infections-spirochetes/lyme-disease

  About 25% of infected people never develop or at least never notice the characteristic rash. […] Fatigue, chills, fever, headaches, stiff neck, muscle aches, and painful, swollen joints are common. […] These symptoms of Lyme disease may last for weeks. […] In nearly half of people who are not treated, more, usually smaller erythema migrans spots appear on other parts of the body. […] Although most symptoms come and go, feelings of illness and fatigue may last for weeks. […] The nervous system is affected in about 15% of people. […] Common problems are meningitis (which causes headache and a stiff neck) and Bell palsy (which causes weakness on one side or occasionally both sides of the face). […] Up to 8% of infected people develop heart problems. […] Arthritis develops in more than half of people, usually within several months. […] A few people develop abnormalities related to brain and nerve malfunction.

• #2 Lyme disease: clinical diagnosis and treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5864449/

  Neuroborreliosis has a clinical spectrum that can include meningitis, facial paralysis, motor or sensory radiculopathy, and cognitive symptoms. […] If left untreated, Lyme disease can evolve into late disease, which presents with persistent arthritis and/or persistent neuroborreliosis. […] In North America, up to 60% of untreated Lyme disease cases show monoarticular or oligoarticular arthritis, usually involving the knees, with other joints such as the ankle, elbow and wrist less commonly affected. […] Up to 10% of patients will have evidence of synovitis six months after treatment for Lyme arthritis, termed antibiotic refractory Lyme arthritis. […] The most common manifestation of neuroborreliosis in North America is subacute encephalopathy with subtle cognitive changes. […] It is clear that a proportion of patients with confirmed evidence of previous Lyme disease continue to have symptoms after standard antimicrobial treatment. […] Persistent symptoms include fatigue, generalized musculoskeletal pain and cognitive impairment without objective findings or microbiological evidence of active infection.

• #2 Lyme Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK431066/

  Lyme arthritis tends to affect large joints, especially the knee. Symptoms manifest as joint pain with swelling and stiffness. Smaller joints, such as the elbow, may be involved, and episodes of bursitis or tendinitis may occur. Over time, in most cases, symptoms tend to subside even without intervention. In a small proportion of patients with Lyme arthritis, chronic inflammatory arthritis similar to rheumatoid arthritis may develop. This complication of Lyme disease is termed postinfectious Lyme arthritis.

• #2 Late Stage Lyme Disease: Symptoms and Treatments | Ada

  https://ada.com/conditions/late-lyme-disease/

  Symptoms of late Lyme disease may include joint pain (arthritis), skin changes, and musculoskeletal or neurologic complications. […] Late Lyme disease usually develops 6-36 months after a person first receives the causal infectious tick bite. […] The symptoms of late Lyme disease differ from the earlier stages. In North America, joint pain and swelling is very common. In Europe, skin changes are more common. These skin changes consist of swelling, redness and thinning of the skin on usually one hand or one foot. Other symptoms of LLD may include arthritis, weakness of the facial muscles, heart palpitations and aching muscles. […] Although some people may develop neurologic problems, these are rare, but may include: Lack of stamina and fatigue, Tingling and numbness in the hands and feet, Confusion, Memory problems, Difficulty concentrating, Headaches.

• #2 Lyme Disease: Symptoms, Signs, Treatment, and More

  https://www.healthline.com/health/lyme-disease

  Lyme disease results from the bite of an infected tick. It can cause many symptoms, including a bulls-eye rash and joint pain, and may result in post-Lyme disease syndrome. […] Symptoms of Lyme disease vary depending on the stage of infection. […] For example, symptoms of stages 1 and 2 may overlap. Or, you may not experience any stage 1 symptoms but experience later symptoms. […] One of the earliest signs of the disease is a bulls-eye rash, also known as an erythema migrans. […] Other symptoms commonly seen in stage 1 of Lyme disease include: chills, fever, enlarged lymph nodes, sore throat, vision changes, fatigue, muscle aches, headaches. […] Early disseminated Lyme disease can appear up to 3 months after the tick bite, while late disseminated Lyme disease may take up to 12 months.

• #2 Lyme Disease: Symptoms, Signs, Treatment, and More

  https://www.healthline.com/health/lyme-disease

  Stages 2 and 3 of Lyme disease are characterized by systemic infection. This means the infection has spread throughout your body, including to other organs. […] Symptoms may include: abnormal heart rhythm, which can be caused by Lyme carditis, neurologic conditions, such as facial palsies and cranial neuropathy, multiple erythema migrans lesions on your body, numbness, tingling, and pain in your hands and feet, severe headaches, neck stiffness, meningitis, arthritis of one or more large joints, typically the knee, encephalopathy, which may cause short-term memory loss, difficulty concentrating, mental fogginess, problems with following conversations, and sleep disturbance. […] Its important to note that you may experience later symptoms of Lyme disease without experiencing earlier symptoms, such as a bulls eye rash.

• #2 Lyme Disease Symptoms | LymeDisease.org

  https://www.lymedisease.org/lyme-basics/lyme-disease/symptoms/

  In our survey, which drew over 5,000 responses, patients with chronic Lyme disease reported an average of three severe or very severe symptoms, with 74% reporting at least one symptom as severe or very severe. […] Many Lyme symptoms, such as fatigue, cognitive impairment, joint pain, poor sleep, mood problems, muscle pain, and neurological presentations also occur in other diseases. […] Hence, the symptoms of Lyme disease significantly overlap those of chronic fatigue, fibromyalgia, rheumatoid arthritis, multiple sclerosis, Parkinsons disease, ALS, depression and Alzheimers disease. […] Many Lyme patients report being misdiagnosed with a different condition before being properly diagnosed with Lyme disease.

• #2 Lyme Disease Is Hard to Identify; Increasing Rapidly

  https://www.afmc.org/blog/lyme-disease-is-hard-to-identify-increasing-rapidly

  Chronic LD symptoms can include the early symptoms listed above, plus these: Cognitive issues 66 percent, Depression 62 percent, Neuropathy (nerve pain, numbness, tingling, hot/cold sensations) 61 percent, Heart problems 31 percent. […] Many doctors have difficulty pinpointing LD because its symptoms overlap with symptoms for ALS, Alzheimers disease, chronic fatigue, depression, fibromyalgia, multiple sclerosis, Parkinsons disease, and rheumatoid arthritis, according to lymedisease.org.

• #2 Signs and Symptoms | Lyme Disease

  https://www.columbia-lyme.org/signs-and-symptoms

  Oblong rash associated with Lyme. […] A „sign” in medicine is something that can be confirmed by an outside observer. […] These would include such manifestations of Lyme disease as a swollen joint, a facial palsy, a Lyme rash. […] A „symptom” refers to a manifestation that can’t be confirmed by an outside observer; the physician has to rely on the patient’s report of the experience such as pain or fatigue or brain fog. […] Some doctors make the error of only relying on „signs” and not taking into account the range of „symptoms” that together form a pattern that is typical for Lyme disease. […] For example, studies have shown that about 20% of patients with new onset Lyme disease only present with fatigue, muscle and joint pain, headache and malaise. […] While the erythema migrans (EM) rash is the most common presentation of Lyme disease, it may not be seen in 20 to 30 percent of cases.

• #2

• #2 Lyme disease: clinical diagnosis and treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5864449/

  The studies found similar efficacy for amoxicillin, azithromycin, cefuroxime and doxycycline independent of the dose and duration of therapy. […] Prognosis: Both clinical trials and observational studies provide information about the prognosis for treated early Lyme disease. […] While it is not unusual for individuals to have symptoms such as fatigue and arthralgias after treatment for Lyme, most studies reported either no or few ( 5%) late manifestations of disseminated Lyme. […] Early disease may be followed by disseminated disease, with the development of multiple secondary annular lesions and multisystem and intermittent cardiac, neurological, ocular or articular manifestations. […] The most common presentation is atrioventricular block ranging from first to third degree heart block, often requiring temporary pacing.

• #2 Pediatric Lyme Disease – Conditions and Treatments | Children’s National Hospital

  https://www.childrensnational.org/get-care/health-library/lyme-disease

  Weeks to months after the bite, these symptoms may develop: nervous system symptoms, such as inflammation of the nervous system (meningitis) and weakness and paralysis of the facial muscles (Bell palsy); heart problems, such as inflammation of the heart (myopericarditis) and problems with heart rate; eye problems, such as inflammation of the eyes; skin disorders; severe tiredness; weakness. […] Months to a few years after a bite, these symptoms may occur: inflammation of the joints (arthritis); nervous system symptoms such as numbness in the arms and legs, tingling and pain, and trouble with speech, memory and concentration. […] The symptoms of Lyme disease can be like other health conditions. Make sure your child sees a healthcare provider for a diagnosis.

• #2 Lyme Disease Stages: How Untreated Lyme Disease Progresses

  https://www.verywellhealth.com/lyme-disease-stages-5176671

  Various neurological symptoms can occur depending on the area of the nervous system affected. Some symptoms may be similar to stage 2 but can be more extensive, severe, or longer-lasting. If the infection has traveled to the brain, you may experience: Difficulty following conversations and processing information, Mental fogginess, Trouble sleeping, Vertigo or dizziness. […] Oral antibiotics are typically used for Lyme arthritis, while intravenous antibiotics treat neurologic issues. The length of therapy can be two to four weeks, depending on the symptoms. […] Early detection and treatment of Lyme disease may prevent the infection from progressing to later stages of the illness. […] Be sure to contact your doctor if you are experiencing any of the previously discussed symptoms (even if you don’t have a rash) including flu-like symptoms, muscle or joint pain, or fatigue.

• #3

  https://myhealth.alberta.ca/Health/pages/conditions.aspx?Hwid=ty3183

  There are three stages of Lyme disease. If the disease isn’t treated, it may progress in stages from mild symptoms to serious, long-term disabilities. […] Stage 1, or early localized Lyme disease, occurs within one month of the tick bite. You may have an expanding, circular red rash (erythema migrans), and/or flu-like symptoms. Some people do not have symptoms. […] Stage 2, or early disseminated infection, can develop days to weeks after you become infected. If Lyme disease isn’t found or treated early, the infection may affect the skin, joints, nervous system, and heart within weeks to months after the initial infection. […] Stage 3, or late persistent Lyme disease, can develop months or years after infection. If the disease hasn’t been promptly or effectively treated, you may have damage to the joints, nerves, and brain. It is the last and often the most serious stage of the disease.

• #3 Lyme Disease: Symptoms, Treatment, Prevention & Recovery

  https://my.clevelandclinic.org/health/diseases/11586-lyme-disease

  Lyme disease may evolve through phases (stages), which can overlap and cause symptoms that may involve the skin, joints, heart or nervous system. These stages are: […] Signs and symptoms of early Lyme disease typically include: […] A reddish rash or skin lesion known as erythema migraines (EM). The rash starts as a small red spot at the site of the tick bite anywhere from one week after to four weeks after the bite. The spot expands over a period of days or weeks, forming a circular, triangular or oval-shaped rash. The rash may look like a bulls eye because it appears as a red ring that surrounds a clear center area. The rash can range in size from that of a dime to the entire width of a person’s back. As infection spreads, several EM rashes (lesions) can appear at different sites on your body.

• #3 Lyme Disease Symptoms : Johns Hopkins Lyme Disease Research Center

  https://www.hopkinslyme.org/lyme-disease/lyme-disease-signs-symptoms/

  In the first early localized stage of Lyme disease the skin at the site of the tick bite becomes infected with Borrelia burgdorferi bacteria. The initial infection can cause an expanding round or oval red skin lesion called erythema migrans and associated flu-like symptoms within days to a month after the tick bite. Early symptoms can include achiness, chills, fever, sweats, fatigue, malaise, headache, stiff neck, muscle soreness, joint pain, swollen lymph nodes, and sore throat. The combination of the skin lesion and flu-like symptoms are the primary manifestations of acute stage Lyme disease, although the rash and flu-like symptoms are not always present. […] The symptoms of second stage, early disseminated, Lyme disease can be difficult to attribute. Symptoms include severe fatigue, fever, pain, intermittent weakness and achiness of the muscles and joints, numbness in arms and legs, vision changes, and cognitive dysfunction such as short-term memory difficulties and problems multitasking. These symptoms are not specific for Lyme disease and can make the diagnosis of second stage Lyme disease very challenging.

• #3 Lyme disease Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/lyme-disease

  If Lyme disease continues to be left untreated, it can become established in various parts of the body over months or years after the initial infection. Symptoms include: Joint pain and swelling (Lyme arthritis). Approximately 60% of people not treated with antibiotics will develop recurring attacks of arthritis. Nerve damage. This results in numbness in hands or feet, shooting pains, and tingling. Neurological problems. These can include confusion, memory loss, sudden loss of hearing, or speech problems. […] Most people who are treated with antibiotics make a full recovery. Getting early treatment can help avoid complications. Complications include arthritis, heart disease, and neurologic complications.

• #3 Taking the bite out of Lyme disease – Northwestern Now

  https://news.northwestern.edu/stories/2025/04/taking-the-bite-out-of-lyme-disease/

  Lyme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually. Lyme can be devastating; but early treatment with antibiotics can prevent chronic symptoms like heart and neurological problems and arthritis from developing. […] Symptoms that persist long after Lyme disease is treated are not uncommon a 2022 study found that 14% of patients who were diagnosed and treated early with antibiotic therapy would still develop Post Treatment Lyme Disease (PTLD). Yet doctors puzzle over the conditions causes and how to help their patients through symptoms ranging from severe fatigue and cognitive challenges to body pain and arthritis. […] Northwestern scientists believe they now know what causes the treated infection to mimic chronic illness: The body may be responding to remnants of the Borrelia cell wall which breaks down during treatment yet lingers in the liver.

• #3 What doctors wish patients knew about Lyme disease | American Medical Association

  https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-lyme-disease

  Some people can have persistent symptoms such as fatigue, pain, sleep problems, depressed mood and clouded thinking that go beyond six months. […] About 90% of people fully recover from Lyme disease, Dr. Auwaerter said. There is a lag that some people experience that can take weeks or even a couple months to fully improve but antibiotics eradicate the bacteria. […] If you develop symptoms after getting bitten by a tick, be sure to go to your doctor immediately for evaluation and mention your recent tick bite.

• #3 What Are the Symptoms of Chronic Lyme Disease? | IGeneX | Tick Talk

  https://igenex.com/tick-talk/what-are-the-symptoms-of-chronic-lyme-disease/

  Chronic Lyme survivors have reported experiencing the following symptoms for months to years after infection: Intermittent fevers, chills, and sweats, Chronic inflammation, Roving aches and stiffness, Numbness and tingling in the limbs, Dizziness and shortness of breath, Tremors, Respiratory infections, Sore throats, Stomach pains, Heart palpitations and irregular heartbeat, Anxiety and paranoia, Rage, Hallucinations, Hearing sensitivity, Dysphonia (vocal cord damage), New food allergies, Multiple-chemical sensitivities, Seizures. […] Chronic Lyme disease can be linked to deadly symptoms, such as Lyme carditis (inflammation of the heart). […] According to Lymedisease.org, studies consistently show that chronic Lyme disease patients have poorer quality of life than those with other chronic diseases. One of their own studies showed that 75% of surveyed patients reported at least one symptom as severe or very severe.

Zobacz więcej