Trimetyloaminuria (zespół zapachu rybnego)
Zapobieganie i profilaktyka
Trimetyloaminuria (TMAU) to rzadkie, autosomalnie recesywne zaburzenie metaboliczne charakteryzujące się nadmierną produkcją trimetyloaminy (TMA), co skutkuje nieprzyjemnym, rybnym zapachem ciała. Diagnostyka opiera się na ocenie objawów i badaniach biochemicznych, a leczenie przyczynowe nie jest obecnie dostępne. Podstawą terapii jest modyfikacja diety, polegająca na ograniczeniu spożycia prekursorów TMA, takich jak trimetyloamina N-tlenek (TMAO) i cholina, obecnych w rybach morskich, mleku krowim, jajach, roślinach strączkowych, podrobach oraz warzywach kapustowatych. Zaleca się unikanie suplementów zawierających lecytynę. Warto podkreślić, że ryby słodkowodne są dopuszczalne w diecie, a cholina w żółtkach jaj może nie być metabolizowana do TMA. Przed wprowadzeniem zmian dietetycznych konieczna jest konsultacja z dietetykiem, aby zapobiec niedoborom składników odżywczych, zwłaszcza że cholina jest niezbędna dla wielu funkcji organizmu.
Trimetyloaminuria (zespół zapachu rybnego) – ogólna charakterystyka
Trimetyloaminuria (TMAU), znana również jako „zespół zapachu rybnego”, jest rzadkim zaburzeniem metabolicznym, które powoduje nieprzyjemny, rybny zapach wydzielany przez organizm. Choroba ta jest dziedziczona w sposób autosomalny recesywny, co zostało potwierdzone w badaniach obejmujących 187 pacjentów z podejrzeniem przykrego zapachu ciała1. Obecnie nie istnieje skuteczne leczenie przyczynowe TMAU, jednak dostępnych jest wiele metod, które mogą znacząco złagodzić objawy i poprawić jakość życia pacjentów234.
Metody profilaktyki trimetyloaminurii
Modyfikacja diety
Modyfikacja diety stanowi podstawę leczenia TMAU, ponieważ unikanie prekursorów trimetyloaminy zmniejsza nieprzyjemny zapach ciała5. Kluczowe jest ograniczenie spożycia pokarmów bogatych w trimetyloaminę N-tlenku (TMAO) oraz cholinę, które zwiększają ilość trimetyloaminy (TMA) w organizmie67. Zaleca się unikanie następujących produktów:
- Ryby morskie (słonowodne), w tym głowonogi i skorupiaki, które zawierają najwyższe stężenie prekursora trimetyloaminy N-tlenku8
- Mleko krowie, szczególnie od krów karmionych pszenicą, które może zawierać duże ilości TMA910
- Jaja (szczególnie żółtka)1112
- Rośliny strączkowe: soja, fasola, groch, orzeszki ziemne1314
- Podroby: wątroba, nerki1516
- Warzywa z rodziny kapustowatych, w tym rzepak17
- Suplementy zawierające lecytynę1819
Należy podkreślić, że ryby słodkowodne mogą być spożywane przez osoby z TMAU20. Możliwe, że cholina znajdująca się w żółtkach jaj występuje w formie, która nie jest przekształcana w trimetyloaminę przez bakterie jelitowe21.
Ważne: Przed wprowadzeniem jakichkolwiek zmian w diecie, konieczna jest konsultacja z dietetykiem, aby zapewnić prawidłową, zbilansowaną dietę zawierającą wszystkie niezbędne składniki odżywcze222324. Cholina jest niezbędnym składnikiem odżywczym potrzebnym organizmowi do wielu funkcji, dlatego ograniczanie jej spożycia bez definitywnej biochemicznej diagnozy TMAU mogłoby być szkodliwe dla zdrowia25.
Higiena osobista
Prawidłowa higiena osobista może pomóc w redukcji nieprzyjemnego zapachu26:
- Częste mycie ciała za pomocą mydła o niskim pH (5,5-6,5), które pomaga usunąć ślady trimetyloaminy ze skóry i włosów272829
- Używanie antyperspirantów30
- Częste pranie ubrań3132
Utrzymanie naturalnego pH skóry na poziomie 5,5 jest szczególnie istotne, ponieważ kwas rozkłada TMAU wydzielane przez skórę. Mydła, wybielacze i kryształy sody są ogólnie zasadowe, dlatego należy wybierać produkty o odpowiednim pH33.
Modyfikacja stylu życia
Istotne jest również wprowadzenie zmian w stylu życia3435:
- Unikanie intensywnego wysiłku fizycznego, który zwiększa wydzielanie potu3637
- Znalezienie sposobów na relaksację i redukcję stresu, który również może nasilać objawy poprzez zwiększone pocenie3839
Farmakologiczne metody wspomagające
Antybiotykoterapia
Niektórzy pacjenci dobrze reagują na kurację antybiotykami takimi jak neomycyna, amoksycylina czy metronidazol, które zmieniają skład bakterii jelitowych, ograniczając produkcję trimetyloaminy404142. Metoda ta jest szczególnie skuteczna w:
- Wtórnej trimetyloaminurii spowodowanej przerostem bakterii jelitowych43
- W pierwotnej trimetyloaminurii podczas ważnych sytuacji społecznych lub gdy nie można utrzymać ograniczeń dietetycznych44
Aby zmniejszyć ryzyko antybiotykooporności, antybiotyki powinny być stosowane jedynie okresowo lub naprzemiennie co 2 tygodnie45.
Suplementacja
Lekarz może zalecić przyjmowanie określonych suplementów46:
- Ryboflawina (witamina B2) – teoretycznie może przynieść korzyści, ponieważ enzym FMO3 (odpowiedzialny za metabolizm TMA) ma kofaktor flawinowy, choć nie zostało to potwierdzone badaniami klinicznymi4748
- Węgiel aktywny, który może pomóc w absorbcji nieprzyjemnych związków49
- Doustny chlorofilin miedziowy, który może przynieść tymczasową poprawę poprzez zmianę składu bakterii jelitowych50
- Laktuloza – może być stosowana w krótkotrwałej terapii51
Wsparcie psychologiczne
TMAU może być psychologicznie upośledzającym stanem, który znacząco wpływa na jakość życia pacjentów52. Niezwykle ważne jest, aby:
- Oferować skierowanie na poradnictwo psychiatryczne5354
- Regularnie monitorować pod kątem depresji i myśli samobójczych55
- Informować zespół medyczny o swoim stanie psychicznym – pacjenci mają prawo do wsparcia, które pomoże im radzić sobie z zaburzeniem56
- Korzystać z terapii i internetowych grup wsparcia, które mogą zapewnić istotne wsparcie emocjonalne, jeśli zdrowie psychiczne i społeczne pacjenta jest zaburzone przez tę chorobę57
Kompleksowe podejście do profilaktyki
Chociaż obecnie nie ma lekarstwa na trimetyloaminurię, zastosowanie kompleksowego podejścia obejmującego modyfikację diety, odpowiednią higienę osobistą, okresowe stosowanie antybiotyków, suplementację oraz wsparcie psychologiczne może znacząco poprawić jakość życia pacjentów5859. Należy pamiętać, że objawy TMAU mogą fluktuować w czasie, a indywidualne podejście do każdego pacjenta jest kluczowe dla skutecznego zarządzania chorobą60.
Ze względu na biochemiczną naturę nadmiernej produkcji TMA, trimetyloaminuria jest powiązana ze spożyciem pokarmów bogatych w cholinę. Pacjenci powinni konsultować się z lekarzem przed próbą ograniczenia spożycia choliny, aby zapewnić odpowiednie odżywianie organizmu61. Eksperci zalecają konsultację z dietetykiem i/lub licencjonowanym żywieniowcem przed wprowadzeniem większych zmian w diecie62.
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Materiały źródłowe
- #1https://omim.org/entry/602079
Treatment for trimethylaminuria can involve counseling, dietary adjustments, short-course treatment with metronidazole, neomycin, or lactulose, and the use of soaps with a pH value of 5.5-6.5 (Rehman, 1999). […] Ayesh et al. (1993) studied 187 subjects with suspected body malodor and concluded that the trimethylaminuria is inherited as an autosomal recessive trait.
- #2 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #3 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #4 Trimethylaminuria (’fish odour syndrome’) | Health Information from Mediclinic Pharmacyhttps://mediclinicpharmacy.com/nhs_conditions_trimethylaminuria
Trimethylaminuria (’fish odour syndrome’) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, and supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, and wash your clothes frequently. […] Your doctor may recommend short courses of antibiotics to help reduce the amount of trimethylamine produced in your gut.
- #5 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #6 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #7 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #8 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #9 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #10 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #11 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #12 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #13 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #14 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #15 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #16 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #17 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #18 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #19 Trimethylaminuria (’fish odour syndrome’) | Health Information from Mediclinic Pharmacyhttps://mediclinicpharmacy.com/nhs_conditions_trimethylaminuria
Trimethylaminuria (’fish odour syndrome’) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, and supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, and wash your clothes frequently. […] Your doctor may recommend short courses of antibiotics to help reduce the amount of trimethylamine produced in your gut.
- #20 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #21 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #22 Trimethylaminuria – Metabolic Support UKAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontResethttps://metabolicsupportuk.org/condition/trimethylaminuria/
There is currently no cure for Trimethylaminuria. However, there are a number of steps you can take to improve the symptoms. These include: […] Before you make any changes to the foods you eat, it is very important to consult a dietician to ensure that you have a healthy, balanced diet that also helps you to successfully manage your disorder. […] It is important that you inform your medical team if you do feel this way. You are entitled to support that will help you to cope with your disorder.
- #23 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #24 Monellâs TMAU Legacy – Monell Chemical Senses Centerhttps://monell.org/tmau/
Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. […] Currently there is no cure for TMAU, but treatment options, including avoidance of choline-containing foods, may help reduce odor production. However, choline is an essential nutrient that is needed by your body for many functions. This means that restricting your choline intake without having definitive biochemical TMAU testing and diagnosis could be detrimental to your health. Always consult your physician before trying to restrict dietary choline. […] Experts who have tackled the choline question to better understand TMAU recommend consulting a registered dietitian and/or a licensed nutritionist before making major changes in your diet.
- #25 Monellâs TMAU Legacy – Monell Chemical Senses Centerhttps://monell.org/tmau/
Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. […] Currently there is no cure for TMAU, but treatment options, including avoidance of choline-containing foods, may help reduce odor production. However, choline is an essential nutrient that is needed by your body for many functions. This means that restricting your choline intake without having definitive biochemical TMAU testing and diagnosis could be detrimental to your health. Always consult your physician before trying to restrict dietary choline. […] Experts who have tackled the choline question to better understand TMAU recommend consulting a registered dietitian and/or a licensed nutritionist before making major changes in your diet.
- #26 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #27 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Dietary modification is the basis of treatment as avoidance of trimethylamine precursors reduces the body odour: Marine (sea- or salt-water) fish, including cephalopods and crustaceans, must be avoided completely as they have the highest concentration of the precursor trimethylamine N-oxide. Freshwater fish can be eaten. […] Foods identified to be high in choline include egg yolks, soyabeans, peas, beans, peanuts and other legumes, liver, kidney and other offal, and brassicas such as rapeseed (canola). It is possible that the choline in egg yolks is in a form that is not converted to trimethylamine by bowel bacteria. Foods in this category may be eaten in reduced amount by some sufferers. […] Washing with low pH (pH5.5-6.5) soaps and shampoos removes traces of trimethylamine from the skin and hair.
- #28 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #29 Woman, 41, reveals she has rare condition which makes her smell like fish | Daily Mail Onlinehttps://www.dailymail.co.uk/femail/article-10895691/Woman-41-reveals-rare-condition-makes-smell-like-fish.html
Kelly has sought out ways of improving the symptoms over the years, including adopting a reduced choline diet. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Sadly, there is no cure for Kelly’s condition but avoiding certain foods and supplementing nutrient levels can lessen the symptoms, which fluctuate over time. […] I ultimately learned that the skin needs to remain at its natural pH of 5.5 as acid breaks down TMAU as it comes through the skin soaps, bleach and soda crystals are generally alkali.
- #30 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #31 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #32 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #33 Woman, 41, reveals she has rare condition which makes her smell like fish | Daily Mail Onlinehttps://www.dailymail.co.uk/femail/article-10895691/Woman-41-reveals-rare-condition-makes-smell-like-fish.html
Kelly has sought out ways of improving the symptoms over the years, including adopting a reduced choline diet. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Sadly, there is no cure for Kelly’s condition but avoiding certain foods and supplementing nutrient levels can lessen the symptoms, which fluctuate over time. […] I ultimately learned that the skin needs to remain at its natural pH of 5.5 as acid breaks down TMAU as it comes through the skin soaps, bleach and soda crystals are generally alkali.
- #34 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #35 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #36 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #37 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #38 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #39 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #40 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Some sufferers respond well to courses of neomycin, amoxicillin or metronidazole as these alter the bowel bacteria, reducing the production of trimethylamine. This will be particularly helpful in secondary trimethylaminuria due to bacterial overload and can be used in primary trimethylaminuria for important social situations or when dietary restriction cannot be maintained. […] To reduce the risk of antibiotic-resistance, antibiotics should only be used intermittently or alternated every 2 weeks. […] Oral copper-chlorophyllin may also give temporary improvement by altering the bowel bacteria.
- #41 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #42https://omim.org/entry/602079
Treatment for trimethylaminuria can involve counseling, dietary adjustments, short-course treatment with metronidazole, neomycin, or lactulose, and the use of soaps with a pH value of 5.5-6.5 (Rehman, 1999). […] Ayesh et al. (1993) studied 187 subjects with suspected body malodor and concluded that the trimethylaminuria is inherited as an autosomal recessive trait.
- #43 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Some sufferers respond well to courses of neomycin, amoxicillin or metronidazole as these alter the bowel bacteria, reducing the production of trimethylamine. This will be particularly helpful in secondary trimethylaminuria due to bacterial overload and can be used in primary trimethylaminuria for important social situations or when dietary restriction cannot be maintained. […] To reduce the risk of antibiotic-resistance, antibiotics should only be used intermittently or alternated every 2 weeks. […] Oral copper-chlorophyllin may also give temporary improvement by altering the bowel bacteria.
- #44 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Some sufferers respond well to courses of neomycin, amoxicillin or metronidazole as these alter the bowel bacteria, reducing the production of trimethylamine. This will be particularly helpful in secondary trimethylaminuria due to bacterial overload and can be used in primary trimethylaminuria for important social situations or when dietary restriction cannot be maintained. […] To reduce the risk of antibiotic-resistance, antibiotics should only be used intermittently or alternated every 2 weeks. […] Oral copper-chlorophyllin may also give temporary improvement by altering the bowel bacteria.
- #45 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Some sufferers respond well to courses of neomycin, amoxicillin or metronidazole as these alter the bowel bacteria, reducing the production of trimethylamine. This will be particularly helpful in secondary trimethylaminuria due to bacterial overload and can be used in primary trimethylaminuria for important social situations or when dietary restriction cannot be maintained. […] To reduce the risk of antibiotic-resistance, antibiotics should only be used intermittently or alternated every 2 weeks. […] Oral copper-chlorophyllin may also give temporary improvement by altering the bowel bacteria.
- #46 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #47 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
If restriction is not a viable option, a theoretical benefit may be derived from supplementation with riboflavin since FMO3 has a flavin cofactor; however, this has not been substantiated with any clinical study. […] Another treatment, which exerts its effect in the gastrointestinal tract, is the use of antimicrobials. […] Lastly, it is of great importance to offer a referral to psychiatric counseling and to screen regularly for depression and suicidal ideation.
- #48 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #49 Trimethylaminuria (’fish odour syndrome’) – EM Doctorshttps://www.em-doctors.com/conditions/trimethylaminuria
Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] There’s currently no cure, but there are things that can help. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your specialist can refer you to a dietitian for advice. They’ll help you make sure your diet still contains all the nutrients you need. […] It can also be helpful to: avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, wash your clothes frequently. […] Your doctor may recommend: short courses of antibiotics, taking certain supplements such as charcoal or riboflavin (vitamin B2).
- #50 Trimethylaminuriahttps://dermnetnz.org/topics/trimethylaminuria
Some sufferers respond well to courses of neomycin, amoxicillin or metronidazole as these alter the bowel bacteria, reducing the production of trimethylamine. This will be particularly helpful in secondary trimethylaminuria due to bacterial overload and can be used in primary trimethylaminuria for important social situations or when dietary restriction cannot be maintained. […] To reduce the risk of antibiotic-resistance, antibiotics should only be used intermittently or alternated every 2 weeks. […] Oral copper-chlorophyllin may also give temporary improvement by altering the bowel bacteria.
- #51https://omim.org/entry/602079
Treatment for trimethylaminuria can involve counseling, dietary adjustments, short-course treatment with metronidazole, neomycin, or lactulose, and the use of soaps with a pH value of 5.5-6.5 (Rehman, 1999). […] Ayesh et al. (1993) studied 187 subjects with suspected body malodor and concluded that the trimethylaminuria is inherited as an autosomal recessive trait.
- #52 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #53 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
If restriction is not a viable option, a theoretical benefit may be derived from supplementation with riboflavin since FMO3 has a flavin cofactor; however, this has not been substantiated with any clinical study. […] Another treatment, which exerts its effect in the gastrointestinal tract, is the use of antimicrobials. […] Lastly, it is of great importance to offer a referral to psychiatric counseling and to screen regularly for depression and suicidal ideation.
- #54https://omim.org/entry/602079
Treatment for trimethylaminuria can involve counseling, dietary adjustments, short-course treatment with metronidazole, neomycin, or lactulose, and the use of soaps with a pH value of 5.5-6.5 (Rehman, 1999). […] Ayesh et al. (1993) studied 187 subjects with suspected body malodor and concluded that the trimethylaminuria is inherited as an autosomal recessive trait.
- #55 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
If restriction is not a viable option, a theoretical benefit may be derived from supplementation with riboflavin since FMO3 has a flavin cofactor; however, this has not been substantiated with any clinical study. […] Another treatment, which exerts its effect in the gastrointestinal tract, is the use of antimicrobials. […] Lastly, it is of great importance to offer a referral to psychiatric counseling and to screen regularly for depression and suicidal ideation.
- #56 Trimethylaminuria – Metabolic Support UKAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontResethttps://metabolicsupportuk.org/condition/trimethylaminuria/
There is currently no cure for Trimethylaminuria. However, there are a number of steps you can take to improve the symptoms. These include: […] Before you make any changes to the foods you eat, it is very important to consult a dietician to ensure that you have a healthy, balanced diet that also helps you to successfully manage your disorder. […] It is important that you inform your medical team if you do feel this way. You are entitled to support that will help you to cope with your disorder.
- #57 Trimethylaminuria: Understanding and Treating Fish Odor Syndromehttps://www.healthline.com/health/trimethylaminuria
Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] No cure currently exists for trimethylaminuria. However, you may be able to manage it by carefully choosing what foods you consume. […] Foods to avoid include those high in trimethylamine N-oxide and choline. They increase the amount of TMA in the body. […] Additionally, its important to avoid milk from wheat-fed cows. The milk may contain high amounts of TMA. […] Since intense exercise and high levels of stress can increase sweat levels, people with trimethylaminuria may want to avoid these when possible. […] Although theres no cure for trimethylaminuria, changes to your eating habits may help manage it. Therapy and online support groups can also provide important emotional support if you find that your mental and social health are impacted by the condition.
- #58 A Review of Trimethylaminuria: (Fish Odor Syndrome)https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/
Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] While there is no cure, many simple treatment options exist that may drastically improve the quality of life of these patients. […] An easy first step for the patient might be to wash frequently with an acidic soap (pH 5.5-6.5) and launder clothes on a regular basis. […] Another logical solution to FOS is to exclude or reduce TMAO, a TMA precursor, from the diet, which is found in high concentration in marine fish. […] It would behoove any patient considering dietary restriction as a treatment for FOS to consult a professional dietitian to ensure that all essential nutrients are accounted for prior to beginning a new diet.
- #59 Trimethylaminuria – Metabolic Support UKAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontResethttps://metabolicsupportuk.org/condition/trimethylaminuria/
There is currently no cure for Trimethylaminuria. However, there are a number of steps you can take to improve the symptoms. These include: […] Before you make any changes to the foods you eat, it is very important to consult a dietician to ensure that you have a healthy, balanced diet that also helps you to successfully manage your disorder. […] It is important that you inform your medical team if you do feel this way. You are entitled to support that will help you to cope with your disorder.
- #60 Woman, 41, reveals she has rare condition which makes her smell like fish | Daily Mail Onlinehttps://www.dailymail.co.uk/femail/article-10895691/Woman-41-reveals-rare-condition-makes-smell-like-fish.html
Kelly has sought out ways of improving the symptoms over the years, including adopting a reduced choline diet. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Sadly, there is no cure for Kelly’s condition but avoiding certain foods and supplementing nutrient levels can lessen the symptoms, which fluctuate over time. […] I ultimately learned that the skin needs to remain at its natural pH of 5.5 as acid breaks down TMAU as it comes through the skin soaps, bleach and soda crystals are generally alkali.
- #61 Monellâs TMAU Legacy – Monell Chemical Senses Centerhttps://monell.org/tmau/
Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. […] Currently there is no cure for TMAU, but treatment options, including avoidance of choline-containing foods, may help reduce odor production. However, choline is an essential nutrient that is needed by your body for many functions. This means that restricting your choline intake without having definitive biochemical TMAU testing and diagnosis could be detrimental to your health. Always consult your physician before trying to restrict dietary choline. […] Experts who have tackled the choline question to better understand TMAU recommend consulting a registered dietitian and/or a licensed nutritionist before making major changes in your diet.
- #62 Monellâs TMAU Legacy – Monell Chemical Senses Centerhttps://monell.org/tmau/
Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. […] Currently there is no cure for TMAU, but treatment options, including avoidance of choline-containing foods, may help reduce odor production. However, choline is an essential nutrient that is needed by your body for many functions. This means that restricting your choline intake without having definitive biochemical TMAU testing and diagnosis could be detrimental to your health. Always consult your physician before trying to restrict dietary choline. […] Experts who have tackled the choline question to better understand TMAU recommend consulting a registered dietitian and/or a licensed nutritionist before making major changes in your diet.