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• #1 Trimethylaminuria – Metabolic Support UKAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontReset

  https://metabolicsupportuk.org/condition/trimethylaminuria/

  The main symptom of Trimethylaminuria is a strong odour that may be described as smelling like rotten fish, eggs, rubbish, or urine. The smell is usually noticeable in your sweat, urine, and breath. Females may also experience the smell from their vagina. […] There are reports that suggest the symptoms of the disorder may become worse during puberty. Although Trimethylaminuria may present throughout your life, in a number of cases the smell can fluctuate in its intensity, which means that the smell may be less noticeable at times. For women, the smell can become stronger before and during menstruation. […] Apart from a strong odour, there are no other symptoms of this disorder and most people affected are generally healthy. The disorder has no effect on life expectancy.

• #2 Trimethylaminuria (Fish Odor Syndrome or TMAU)

  https://my.clevelandclinic.org/health/diseases/22356-trimethylaminuria-fish-odor-syndrome

  Trimethylaminuria (TMAU, fish odor syndrome) is an uncommon condition that makes people smell like rotten fish. Its a metabolic disorder. People with TMAU may develop depression and anxiety. Theres no cure for TMAU. But healthcare providers may recommend that you change food choices, stress management techniques and medication to reduce symptoms. […] Trimethylaminuria makes people smell like rotten fish. Avoiding the foods pictured above may help reduce trimethylaminuria symptoms. […] People with TMAU give off an unpleasant nauseating odor that people describe as smelling like rotten fish. The odor may be body odor, bad breath (halitosis) or strong-smelling pee. […] Sometimes, people only notice TMAU symptoms when the person who has the condition sweats or is experiencing stress. But some people with trimethylaminuria carry such a strong scent that others notice the scent just from being in the same room, standing across a counter or sitting in the same section of a bus or train.

• #3

  https://www.omim.org/entry/602079

  Individuals with trimethylaminuria excrete relatively large amounts of amino-trimethylamine (TMA) in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine, leading to the designation fish-odor syndrome. TMA is a product of intestinal bacterial action. The substrates from which it is derived are choline, which, bound to lecithin, is present most abundantly in egg yolk, liver, kidney, legumes, soy beans, and peas, as well as from trimethylamine-N-oxide, a normal constituent of saltwater fishes. Normally, TMA produced in the gut is absorbed and oxidized in the liver by FMO, a microsomal mixed-function oxidase (Higgins et al., 1972). […] Mayatepek and Kohlmuller (1998) described 2 unrelated children with transient trimethylaminuria. One was a 2-month-old female infant referred because of an offensive odor on her skin and from her urine which was noticed by the parents. When the child was 6 months old, the fishy odor completely disappeared. The second patient was a 4-year-old boy who was referred because of smelly urine and skin which had been noticed by his mother from about the age of 18 months. In these children, transient trimethylaminuria occurred without N-oxidation deficiency.

• #4 Trimethylaminuria: Definition, symptoms, and more

  https://www.medicalnewstoday.com/articles/trimethylaminuria

  If a persons body has a fishy smell, they may have trimethylaminuria. This is a genetic rare disorder in which the body cannot break down the chemical trimethylamine. It is sometimes called fish odor syndrome. […] The main symptom of trimethylaminuria is a strong fishlike odor. The body releases excess trimethylaminuria through: breath, sweat, urine, reproductive fluids. […] People may have a persistent strong odor or a milder odor that can change in intensity. […] Trimethylaminuria seems to be more common in females than in males. […] Females may experience more severe symptoms: just before menstruation, during menstruation, after taking oral contraceptives, around menopause. […] People with trimethylaminuria do not usually have any symptoms other than a fishlike odor, and the disorder does not cause any other physical health issues.

• #5 Trimethylaminuria

  https://dermnetnz.org/topics/trimethylaminuria

  Trimethylaminuria is also known as fish (mal)odour syndrome because of the characteristic fishy body odour. […] In trimethylaminuria, this malodourous molecule is excreted in sweat, urine, breath, saliva, vaginal and other body secretions. […] The only feature of this condition is the bad body smell (including halitosis bad breath), of which the sufferer may be completely unaware. […] The smell may fluctuate and triggers for an increase in odour include: Menstruation, with a worsening just before and during a menstrual period. […] However, this offensive body odour causes major social issues resulting in psychological distress and some develop an obsession about personal cleanliness. […] This is a condition with wide-ranging social and psychological effects.

• #6 Trimethylaminuria: Understanding and Treating Fish Odor Syndrome

  https://www.healthline.com/health/trimethylaminuria

  Those with trimethylaminuria produce a body scent thats fish-like. Avoiding certain seafood and eggs can help you manage the smell but will not cure it. […] People who live with it may find themselves feeling self-conscious because their breath and urine have a strong fish odor. […] The most common sign and symptom of trimethylaminuria is a strong fish-like odor. It may be released in: sweat, breath, urine, reproductive fluids. […] The fish-like odor may vary in consistency or stay at a strong level. It may worsen with exercise or stress, since those can increase how much you sweat. […] While trimethylaminuria does not typically have any other physical symptoms besides a fishy odor, it can cause people to socially isolate themselves and lead to depression. […] Trimethylaminuria is a rare condition that produces a fish-like odor. Experts believe a mutation to the FMO3 gene causes it. This mutation leads the body to not being able to break down the chemical compound trimethylamine (TMA).

• #7 Trimethylaminuria – Wikipedia

  https://en.wikipedia.org/wiki/Trimethylaminuria

  Trimethylamine is most noticeable in urine, as it is captured, concentrated and released in intervals. Fishy smelling urine is a primary identifying symptom in infant children (Trimethylaminuria literally meaning „trimethylamine in urine”). […] Trimethylamine is also released in the person’s sweat, reproductive fluids, and breath, and can give off a fishy odor when the concentration of trimethylamine is high enough to be detected. The intensity of the smell is directly correlated with the concentration of trimethylamine in the bloodstream. […] People with TMAU may have an intermittent fish-like body odor, depending on diet and the severity of their FM03 mutation. […] Smell events are often sporadic and episodic in nature (based on diet over the previous 24 hours), making it often difficult to diagnose by smell alone.

• #8 Trimethylaminuria (’fish odour syndrome’) | Health Information from Mediclinic Pharmacy

  https://mediclinicpharmacy.com/nhs_conditions_trimethylaminuria

  Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] Trimethylaminuria symptoms can be present from birth, but they may not start until later in life, often around puberty. […] The only symptom is an unpleasant smell, typically of rotting fish although it can be described as smelling like other things that can affect the breath, sweat, pee, and vaginal fluids. […] The smell may be constant or may come and go. Things that can make it worse include sweating, stress, certain foods such as fish, eggs and beans, and periods. […] See a GP if you notice a strong, unpleasant smell that doesn’t go away. […] They may refer you to a specialist for tests to check for the condition. […] There’s currently no cure for trimethylaminuria, but some things might help with the smell.

• #9 Monell’s TMAU Legacy – Monell Chemical Senses Center

  https://monell.org/tmau/

  Trimethylaminuria (TMAU), sometimes known as “Fish-Odor Syndrome,” is a genetically transmitted metabolic disorder. The main symptom of TMAU is a foul-smelling body odor. The odor can smell like fish in some patients and like garbage in others. […] Some people with TMAU have a strong odor all the time. However, others can have a more moderate smell that is not always present, which can make TMAU hard to diagnose. […] People with TMAU are unable to completely break down trimethylamine (TMA), a chemical found naturally in many foods, especially those containing the essential nutrient choline. As a result, their bodies build up high levels of trimethylamine. The foul-smelling trimethylamine is then excreted in urine, sweat, saliva, and breath.

• #10

  https://111.wales.nhs.uk/encyclopaedia/t/article/Trimethylaminuria(’fishodoursyndrome’)/

  Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome.” […] Trimethylaminuria symptoms can be present from birth, but they may not start until later in life, often around puberty. […] The only symptom is an unpleasant smell, typically of rotting fish although it can be described as smelling like other things that can affect the breath, sweat, pee, and vaginal fluids. […] The smell may be constant or may come and go. Things that can make it worse include sweating, stress, certain foods such as fish, eggs and beans, and periods. […] There’s currently no cure for trimethylaminuria, but some things might help with the smell. […] It can help to avoid certain foods that make the smell worse, such as cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, and supplements containing lecithin. […] Your doctor may recommend short courses of antibiotics; this can help reduce the amount of trimethylamine produced in your gut.

• #11 Trimethylaminuria (’fish odour syndrome’) – EM Doctors

  https://www.em-doctors.com/conditions/trimethylaminuria

  Trimethylaminuria (TMAU) is an uncommon condition that causes an unpleasant, fishy smell. It’s also called „fish odour syndrome”. […] Trimethylaminuria symptoms can be present from birth, but they may not start until later in life, often around puberty. […] The only symptom is an unpleasant smell, typically of rotting fish although it can be described as smelling like other things that can affect the: breath, sweat, pee, vaginal fluids. […] The smell may be constant or may come and go. […] Things that can make it worse include: sweating, stress, certain foods such as fish, eggs and beans, periods. […] There’s currently no cure for trimethylaminuria, but some things might help with the smell. […] It can help to avoid certain foods that make the smell worse, such as: cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, supplements containing lecithin. […] Your doctor may recommend: short courses of antibiotics this can help reduce the amount of trimethylamine produced in your gut, taking certain supplements such as charcoal or riboflavin (vitamin B2).

• #12 Trimethylaminuria (’fish odour syndrome’) | Health Information from Mediclinic Pharmacy

  https://mediclinicpharmacy.com/nhs_conditions_trimethylaminuria

  It can help to avoid certain foods that make the smell worse, such as cows’ milk, seafood and shellfish, eggs, beans, peanuts, liver and kidney, and supplements containing lecithin. […] It can also be helpful to avoid strenuous exercise, try to find ways to relax, wash your skin with slightly acidic soap or shampoo, use anti-perspirant, and wash your clothes frequently. […] Your doctor may recommend short courses of antibiotics to help reduce the amount of trimethylamine produced in your gut.

• #13 Trimethylaminuria – Wikipedia

  https://en.wikipedia.org/wiki/Trimethylaminuria

  Individuals with this condition do not have any physical symptoms, and they typically appear healthy. […] The condition seems to be more common in women than men, for unknown reasons. Scientists suspect that such female sex hormones as progesterone and estrogen aggravate the condition. According to several reports, the condition worsens around puberty. In women, symptoms may worsen just before and during menstrual periods, after taking oral contraceptives, and around menopause. […] Affected individuals experience shame and embarrassment, fail to maintain relationships, avoid contact with people who comment on their condition, and are obsessive about masking the odour with hygiene products and even smoking. The malodorous aspect can have serious and destructive effects on schooling, personal life, career and relationships, resulting in social isolation, low self-esteem, depression, paranoid behaviour, and suicide. Delayed diagnosis, body odour and the lack of cure may lead to psychosocial issues.

• #14 Woman, 41, reveals she has rare condition which makes her smell like fish | Daily Mail Online

  https://www.dailymail.co.uk/femail/article-10895691/Woman-41-reveals-rare-condition-makes-smell-like-fish.html

  Kelly Fidoe-White, 41, from Oldham, Manchester, has lived with Trimethylaminuria (TMAU) her whole life, a disorder more commonly known as 'fish-odour syndrome.’ […] Kelly was formally diagnosed with the condition in 2015 after years of symptoms. […] The 41-year-old had first experienced symptoms when she was six years old, noticing that her urine would smell like fish. […] Years later, when she reached puberty, she developed a prominent body odour which extended beyond her toilet visits. […] To combat the smell, she showered several times a day, not knowing that this actually made the scent worse. […] In fact, it is common for sufferers to smell worse after a shower because the pores open more due to the warm water. […] Trimethylaminuria symptoms can be present from birth, but they may not start until later in life, often around puberty.

• #15 'Fish odor syndrome’: A rare metabolic condition that makes sweat smell like rotten fish | Live Science

  https://www.livescience.com/health/viruses-infections-disease/fish-odor-syndrome-a-rare-metabolic-condition-that-makes-sweat-smell-like-rotten-fish

  Patients with trimethylaminuria, or „fish odor syndrome,” make too much of a chemical with a strong fishy smell. […] TMAU is a rare metabolic condition that causes a person to smell like rotten fish. The condition is more common in women than in men, and there’s evidence that female sex hormones, such as progesterone, can exacerbate patients’ symptoms. […] Symptoms of TMAU may be present from birth or arise later in life, normally near the start of puberty (roughly around age 8 to 13 in females and 9 to 14 in males), when many hormonal changes happen. […] Some patients with TMAU have a strong fishy odor all the time, while the smell may come and go for others with the condition. […] TMAU is not deadly, but the condition can have devastating effects on patients’ quality of life, by impeding their relationships with others and their career, for instance. These impacts can considerably impede their mental health and may lead to symptoms of depression, anxiety and suicidal thoughts in some.

• #16 Trimethylaminuria (Fish Odor Syndrome or TMAU)

  https://my.clevelandclinic.org/health/diseases/22356-trimethylaminuria-fish-odor-syndrome

  Trimethylaminuria can damage your quality of life. Research shows people with the condition often avoid relationships, jobs and activities where others may notice the unpleasant smell that TMAU causes. People with this condition may develop mental health issues, including: Anxiety. Depression. Paranoia. […] Rarely, people with TMAU have suicidal behavior, where they consider suicide. […] Trimethylaminuria is a chronic condition. There isnt a way to cure it and it doesnt go away on its own. But there are treatments and things you can do to reduce TMAU symptoms and the conditions impact on your life. […] Stress can make TMAU symptoms worse. Ask your provider about stress management techniques that can help you lower stress that leads to a more noticeable odor. […] Trimethylaminuria is an uncommon metabolic condition that makes people smell bad. It doesnt hurt, at least in the sense that it doesnt cause physical pain. But it can cause deep emotional wounds that are slow to heal. Some people who have trimethylaminuria go into self-imposed social exile to avoid offending others. Even after changing food choices and other steps, some people with TMAU believe they still need to keep life at arms length. Social isolation may make you feel depressed or anxious.

• #17 A Review of Trimethylaminuria: (Fish Odor Syndrome)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/

  Trimethylaminuria, better known as fish odor syndrome, is a psychologically disabling condition in which a patient emits a foul odor, which resembles that of rotting fish. […] The condition is uncommon, but there has been recent research to suggest that the diagnosis may often be overlooked. […] While not directly life threatening, FOS has a significant psychosocial impact that should not be overlooked. […] Patients with FOS are often ridiculed and suffer from low self-esteem. […] Anxiety can also be an issue for these patients, especially if they are unable to detect their odor. […] Patients also admit to experiencing shame and distress over their condition, and cases of attempted suicide have been noted. […] The disease itself is not life threatening, but it significantly diminishes the quality of patients lives, and has even been associated with suicide attempts.

• #18

  https://www.omim.org/entry/602079

  Todd (1979) noted that patients with TMA may be deeply disturbed, depressed, and even suicidal, with psychosocial problems in school. Rehman (1999) also reported that patients with TMA often have psychosocial problems, including strong feelings of shame, embarrassment, low self-esteem, social isolation, anxiety, and depression.

• #19 Reddit – The heart of the internet

  https://www.reddit.com/r/depression/comments/owpurs/just_a_rant_about_my_disorder/

  It hurts to be lied to and then once you turn your back people laugh or make disgusted noises. Its hard to go out in public because its a strong odor and its simply out of your control. […] (I wanted to explain my disorder a little bit because it may not seem like anything but it ends up giving you many mental illness. I have maladaptive daydreaming disorder, anxiety, depression, etc. now since this started)

• #20 Reddit – The heart of the internet

  https://www.reddit.com/r/IAmA/comments/ua62k/iama_sufferer_of_trimethylaminuria_a_rare_disease/

  I am a 15 year old male, and yes, this disease has haunted me since birth. It is not quite what you may read on wikipedia/google, but it does honestly make me smell. […] The 'fish’ smell isn’t as distinct as real fish. […] I rarely go to school, when i do it is only for mornings as a shower/brush of teeth in the morning can actually really help, my mum offers to homeschool me because she knows what it means to me.

• #21 A Review of Trimethylaminuria: (Fish Odor Syndrome)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3848652/

  While there is no definitive cure at present, it is worth pursuing this diagnosis if clinically indicated as there are reliable diagnostic tests and efficacious treatment options. […] There are many options to reduce the severity of the condition, which range from simple lifestyle changes, such as washing with acidic soap and eating a choline-deficient diet to utilizing antibiotics and sequestering agents. […] TMAU is devastating psychosocially and usually remains undiagnosed for a long period of time; therefore, simply providing those afflicted with the diagnosis can be therapeutic.

• #22 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Fish-Odour-Syndrome-(Trimethylaminuria).aspx

  Fish odour syndrome, also known as trimethylaminuria, is a disorder that causes a strong odour in the urine, sweat and breath of affected individuals, described as similar to rotting fish. […] The main presenting symptom of fish odour syndrome is the fowl smelling body odour coming from the sweat, urine and breath and it doesnt seem to cause any other symptoms beyond the bad smell. […] Many people who suffer from the syndrome also experience psychological effects due to the impact on their daily life. Depression and social isolation are common, affecting personal life and interactions with other people. […] The severity of the condition does not stay constant and can change dramatically throughout different life stages. It is usually worse during puberty and around the time of menstruation and menopause for females. […] It is important for individuals to receive sufficient psychosocial help to assist them in daily life and address the issues that fish odour syndrome places on their wellbeing.

• #23 Trimethylaminuria: Definition, symptoms, and more

  https://www.medicalnewstoday.com/articles/trimethylaminuria

  However, some people may find that the strong odor affects their mental, emotional, or social health. These individuals may socially isolate themselves or experience depression due to the condition. […] The body releases the excess trimethylamine through sweat, urine, breath, and reproductive fluids, giving off a strong fishy odor. […] Trimethylaminuria does not cause any other physical health problems, and people with the condition are usually in good health otherwise. […] It is important that people seek help from a healthcare professional if trimethylaminuria causes social isolation, depression, anxiety, or any other psychological issues.

• #24 Trimethylaminuria (’fish-odour syndrome’): a study of an affected family – PubMed

  https://pubmed.ncbi.nlm.nih.gov/3345632/

  1. Beginning with a single propositus, who had been previously diagnosed at the age of 10 as suffering from trimethylaminuria (fish-odour syndrome), both her parents and two sisters were investigated biochemically with respect to their ability to N-oxidize trimethylamine (TMA), both when derived from the diet and when administered exogenously. […] 2. Both the propositus and a second sister were markedly deficient in their ability to N-oxidize TMA, both when derived from the diet and when given as such; furthermore, both siblings readily developed the symptoms of fish-odour syndrome as characterized by a strong objectionable breath and body odour shortly after the oral administration of TMA (300 mg). […] 4. With an oral challenge of 600 mg of TMA, both the parents showed a clear impairment of N-oxidation capacity which was not seen in six healthy unrelated volunteers. Both parents experienced a fish-odour syndrome at this level of TMA challenge.

• #25 Trimethylaminuria (’fish-odour syndrome’): a study of an affected family – PubMed

  https://pubmed.ncbi.nlm.nih.gov/3345632/

  5. The family data support the hypothesis that trimethylaminuria is an inborn error in the ability to N-oxidize TMA which is inherited as an autosomal recessive trait. Furthermore, experience with this family suggests that an oral challenge dose with 600 mg of TMA may be used to identify carriers of the condition.

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