Łagodne guzy mózgu
Patofizjologia i mechanizm

Łagodne guzy mózgu charakteryzują się powolnym, kontrolowanym wzrostem z wyraźnie określonymi granicami, bez naciekania otaczających tkanek i przerzutów. Mimo łagodnej natury, mogą powodować poważne objawy neurologiczne, głównie poprzez zwiększenie ciśnienia śródczaszkowego, ucisk na sąsiednie struktury mózgowe, zaburzenia przepływu płynu mózgowo-rdzeniowego prowadzące do wodogłowia oraz generowanie napadów padaczkowych. Najczęstsze typy to oponiaki, gruczolaki przysadki, schwannoma i DNET, z różnym pochodzeniem komórkowym i lokalizacją. Czynniki ryzyka obejmują mutacje chromosomu 22 (obecne w 40-80% oponiaków), zaburzenia genetyczne (np. neurofibromatoza typu 2), ekspozycję na promieniowanie w dzieciństwie, płeć żeńską, wiek (40-70 lat) oraz otyłość. Guzy te mogą rosnąć przez dziesięciolecia, a w rzadkich przypadkach ulegać zezłośliwieniu.

Patogeneza i mechanizm łagodnych guzów mózgu

Łagodne guzy mózgu stanowią masę komórek, które rosną w sposób niekontrolowany w obrębie lub w pobliżu mózgu. W przeciwieństwie do złośliwych nowotworów, guzy łagodne charakteryzują się powolnym wzrostem i zazwyczaj nie rozprzestrzeniają się do innych części ciała. Pomimo swojej „łagodnej” natury, mogą one powodować poważne objawy neurologiczne i stanowić zagrożenie dla życia w zależności od ich lokalizacji i wielkości.12

Mechanizm rozwoju guzów łagodnych

Łagodne guzy mózgu powstają, gdy komórki w określonych tkaniach mózgu lub jego okolicach ulegają nieprawidłowemu podziałowi i wzrostowi. W przeciwieństwie do guzów złośliwych, łagodne nowotwory rosną stosunkowo wolno i mają wyraźnie zdefiniowane granice, które tworzą rodzaj torebki. Nie naciekają one przylegających tkanek mózgu.12

Kluczowe cechy mechanizmu rozwoju łagodnych guzów mózgu obejmują:

  • Powolny, kontrolowany wzrost z wyraźnie określonymi granicami1
  • Brak inwazji do otaczających tkanek mózgu1
  • Brak przerzutów do innych części ciała2
  • Wzrost na zasadzie „nadmuchiwanego balonu” z zachowaniem integralności torebki1

Patofizjologia i wpływ na mózg

Pomimo swojej łagodnej natury, guzy mózgu mogą wywoływać poważne objawy neurologiczne poprzez różne mechanizmy patofizjologiczne.12 Do najważniejszych należą:

Wzrost ciśnienia śródczaszkowego

Ponieważ mózg znajduje się w ograniczonej przestrzeni czaszki, wzrost łagodnego guza wraz z towarzyszącym mu obrzękiem może powodować zwiększenie ciśnienia śródczaszkowego. Ten mechanizm jest jednym z najpoważniejszych skutków obecności nawet łagodnego guza w mózgu.12

Skumulowane efekty obecności guza, obrzęku i wodogłowia mogą podwyższać ciśnienie śródczaszkowe i zaburzać perfuzję mózgową. Wzrost ciśnienia w określonych przedziałach śródczaszkowych może prowadzić do przemieszczenia tkanki mózgowej pod sierpem mózgu, przez wcięcie namiotu móżdżku lub przez otwór wielki.1

Ucisk na struktury mózgu

Nawet niewielkie, krytycznie zlokalizowane guzy mogą uszkadzać określone szlaki nerwowe przechodzące przez mózg. Guzy mogą uciskać na otaczającą tkankę mózgową, zaburzając jej normalną funkcję i powodując objawy neurologiczne.11

Zaburzenia przepływu płynu mózgowo-rdzeniowego

Guzy zlokalizowane w pobliżu trzeciej i czwartej komory mózgu mogą utrudniać przepływ płynu mózgowo-rdzeniowego, prowadząc do wodogłowia obturacyjnego. To z kolei może dodatkowo zwiększać ciśnienie śródczaszkowe.11

Angiogeneza i obrzęk

Guzy generują nowe naczynia krwionośne (angiogeneza), zaburzając normalną barierę krew-mózg i promując rozwój obrzęku. Ten mechanizm przyczynia się do zwiększania ciśnienia wewnątrzczaszkowego i może prowadzić do dodatkowych uszkodzeń tkanki mózgowej.1

Zmieniona aktywność elektryczna mózgu

Obecność guza w mózgu może zakłócać normalną funkcję neurologiczną. W miarę wzrostu guza może on wywierać nacisk na pobliskie neurony, prowadząc do nieprawidłowych sygnałów elektrycznych. Ta interferencja może drażnić mózg, wywołując napady padaczkowe.1

Niektóre łagodne guzy, takie jak ganglioglioma czy DNET, są zbudowane z komórek podobnych do neuronów, które tworzą środowisko sprzyjające nadmiernej pobudliwości. To zasadniczo przygotowuje określone części mózgu do napadów, z neuronami wykazującymi zbyt łatwą i spontaniczną aktywność.1

Czynniki ryzyka i przyczyny

Dokładna przyczyna większości łagodnych guzów mózgu pozostaje nieznana. Badacze starają się rozwiązać ten problem, ponieważ lepsze zrozumienie przyczyn guzów mózgu zwiększy szanse na znalezienie sposobów ich zapobiegania.1 Na podstawie analizy dużych grup pacjentów, badacze zidentyfikowali pewne czynniki ryzyka, które zwiększają prawdopodobieństwo rozwoju guza mózgu:

Czynniki genetyczne

Badania wykazały, że od 40% do 80% wszystkich oponiaków (najczęstszych łagodnych guzów mózgu) ma nieprawidłowość w chromosomie 22, który jest zaangażowany w hamowanie wzrostu guzów. Ta nieprawidłowość najczęściej występuje spontanicznie (losowo) lub rzadziej jako część określonych stanów genetycznych (dziedzicznych).12

Osoby z rzadkimi zaburzeniami genetycznymi, takimi jak neurofibromatoza typu 1 i typu 2, zespół Turcota, zespół Li-Fraumeni i stwardnienie guzowate, mają zwiększone ryzyko rozwoju guzów mózgu.12 Pacjenci z neurofibromatozą typu 2 (NF2) są bardziej narażeni na rozwój oponiaków, ponieważ dziedziczą gen, który ma potencjał do przekształcania normalnych komórek w nowotworowe.1

Wcześniejsza ekspozycja na promieniowanie

Ekspozycja na promieniowanie w dzieciństwie jest jedynym znanym środowiskowym czynnikiem ryzyka rozwoju oponiaków.1 Wcześniejsza radioterapia głowy może zwiększać ryzyko guza mózgu.1 Promieniowanie może pochodzić z radioterapii stosowanej w leczeniu innego nowotworu lub z promieniowania używanego w leczeniu stomatologicznym.1

Hormony i płeć

Oponiaki są częstsze u kobiet niż u mężczyzn, co może sugerować, że hormony żeńskie mogą odgrywać rolę w ich rozwoju.1 Niektóre badania sugerują istnienie związku między rakiem piersi a ryzykiem wystąpienia oponiaka, związanego z rolą hormonów. Inne badania sugerują, że stosowanie doustnych środków antykoncepcyjnych i hormonalnej terapii zastępczej może zwiększać ryzyko wzrostu oponiaka.1

Powierzchnie komórek oponiaka mają receptory dla estrogenu, progesteronu lub obu tych hormonów. Oponiaki rosną szybciej w ciąży, gdy organizm naturalnie wytwarza więcej tych hormonów.1 Jeśli kobieta, zwłaszcza ta, która już ma oponiaka, przechodzi ciążę lub terapię hormonalną, może być narażona na ryzyko wzrostu lub powiększenia się guza.1

Wiek

Ryzyko rozwoju wielu nowotworów, w tym nowotworów mózgu, zwiększa się wraz z wiekiem.1 Oponiaki występują najczęściej u osób w wieku od 40 do 70 lat i są częstsze u kobiet. Występują u około 3% osób powyżej 60. roku życia.1

Otyłość

Wysoki wskaźnik masy ciała (BMI) jest czynnikiem ryzyka wielu typów nowotworów. Kilka dużych badań wykazało, że oponiaki występują częściej u osób otyłych. Jednakże związek między otyłością a oponiakami nie jest jasny.1

Rodzaje łagodnych guzów mózgu

Istnieje wiele typów łagodnych guzów mózgu, które różnią się pochodzeniem komórkowym, lokalizacją i charakterystyką wzrostu:12

  • Oponiaki – wywodzą się z komórek opon mózgowych, są najczęstszymi łagodnymi guzami mózgu u dorosłych1
  • Gruczolaki przysadki – łagodne guzy rozwijające się w przysadce mózgowej1
  • Craniopharyngioma – łagodne guzy rozwijające się w pobliżu przysadki mózgowej i podwzgórza1
  • Schwannoma (nerwiak osłonkowy) – łagodne guzy rozwijające się z nerwu łączącego ucho z mózgiem1
  • Naczyniakowłókniak nosogardłowy – rzadki, niezłośliwy guz występujący zwykle u nastoletnich chłopców1
  • Guzy splotu naczyniówkowego – rzadkie, łagodne guzy rozwijające się w splocie naczyniówkowym mózgu1
  • DNET (dysembrioplastyczny guz neuroepitelialny) – rzadki, łagodny guz dotykający głównie dzieci i młodych dorosłych1
  • Nerwiakowłókniaki – łagodne guzy pochodzące z tkanki nerwowej1
  • Naczyniakowłókniaki – łagodne guzy rozwijające się najczęściej w móżdżku12
  • Chrzęstniaki – wolno rosnące łagodne guzy pochodzące z tkanki chrzęstnej1
  • Guzy olbrzymiokomórkowe – zbudowane z dużych komórek, mogą rozwijać się w czaszce, nogach lub kościach ramienia1
  • Kostniakomięsaki – łagodne guzy kostne, które mogą rozwijać się w czaszce lub kościach twarzy1

Łagodne guzy mózgu a zagrożenie życia

Pomimo swojej „łagodnej” nazwy, te guzy mogą stanowić poważne zagrożenie dla zdrowia i życia. Termin „łagodny guz mózgu” jest obecnie używany rzadziej, ponieważ może być mylący.1 Chociaż łagodne guzy mózgu rosną wolniej niż guzy złośliwe, nadal mogą być poważne.1

Łagodne guzy mogą powodować szkody poprzez:

  • Ucisk i uszkodzenie pobliskich obszarów mózgu, z powodu ograniczonej pojemności czaszki1
  • Blokowanie przepływu płynu mózgowo-rdzeniowego, który odżywia i chroni mózg, powodując wzrost ciśnienia w mózgu1
  • Generowanie objawów neurologicznych zależnych od lokalizacji guza1

Nawet wolno rosnący guz może ostatecznie wytworzyć znaczne ciśnienie na mózg, które może powodować objawy i zagrażać życiu.1 W czaszce jest tylko tyle miejsca dla czegokolwiek innego niż mózg, dlatego nawet niezłośliwy guz rosnący wewnątrz głowy może być niebezpieczny.1

Słowo „łagodny” może być mylące w przypadku oponiaków. W zależności od lokalizacji i tempa wzrostu, łagodny guz mózgu oponiaka może naciskać na istotne nerwy lub uciskać mózg, powodując niepełnosprawność. Mogą nawet zagrażać życiu.1

Przebieg naturalny i rokowanie

Łagodne guzy mózgu zwykle rosną powoli, a ich objawy często rozwijają się stopniowo, jeśli w ogóle się rozwijają.1 Większość łagodnych guzów nie powraca po usunięciu chirurgicznym, jednak w niektórych przypadkach mogą one odrosnąć, a wtedy można zastosować radioterapię.1

Chociaż niektóre łagodne guzy całkowicie znikają po leczeniu, niektóre mogą nawracać lub nawet stać się złośliwe. Dlatego ważne jest, aby pacjent współpracował z lekarzem i informował go o wszelkich nowych lub pogarszających się objawach.1

W rzadkich przypadkach niektóre wolno rosnące łagodne guzy odrastają po leczeniu i mogą zmienić się w złośliwy guz mózgu (nowotwór mózgu), który szybko rośnie i prawdopodobnie się rozprzestrzenia.1 Łagodne guzy mogą stać się złośliwe po długim czasie, czasami trwa to dziesięciolecia, jeśli w ogóle do tego dojdzie.1

Podejście terapeutyczne

Leczenie łagodnego guza mózgu zależy od wielu czynników, takich jak typ guza, jego lokalizacja, wielkość, wiek pacjenta oraz czy guz powoduje objawy. Najczęstszymi metodami leczenia łagodnych guzów mózgu są operacja i radioterapia.1

Cel operowania łagodnych guzów mózgu polega na bezpiecznym usunięciu jak największej części masy guza. W przypadkach, gdy guz znajduje się głęboko w mózgu lub w pobliżu wrażliwych struktur, możliwe jest bezpieczne usunięcie tylko części guza. Pozostałe komórki są zarządzane poprzez obserwację, chemioterapię lub radioterapię.1

Coraz częściej odkrywa się, że połączenie operacji i radioterapii jest lepsze niż każda z nich osobno. Jeśli guz jest duży, trudno jest leczyć go samą radioterapią. Operacja pomoże zmniejszyć wielkość guza.1

Jednocześnie nie zawsze bezpieczne jest usunięcie całego guza. Może on dotykać lub otaczać naczynia krwionośne lub inne krytyczne struktury, takie jak nerwy, a próba usunięcia całego guza mogłaby uszkodzić te struktury. W takich przypadkach dąży się do zmniejszenia wielkości tych guzów za pomocą operacji, a następnie leczenia pozostałości za pomocą skoncentrowanej radioterapii, takiej jak radiochirurgia Gamma Knife.1

Jednakże niektóre przypadki niekoniecznie wymagają operacji, chemioterapii lub radioterapii. Na przykład, starszy pacjent z małym guzem mózgu może być po prostu monitorowany za pomocą corocznych badań MRI, aby upewnić się, że guz nie rośnie.1

Większość pacjentów widzi poprawę objawów wkrótce po leczeniu łagodnych guzów. „Zdecydowana większość osób, które mają usunięte guzy mózgu, funkcjonuje lepiej po leczeniu niż przed nim,” mówi dr Fenstermaker. „Istnieją zagrożenia dla istotnych funkcji neurologicznych, których nie można zredukować do zera, ale nowoczesne leczenie guzów mózgu jest wielkim postępem i przynosi korzyści większości pacjentów.”1

Wpływ na jakość życia

Łagodny guz mózgu wiąże się z nieprawidłowym wzrostem w mózgu, który może zakłócać podstawowe funkcje. Guzy te mogą naciskać na krytyczne obszary, powodując uciążliwe objawy, długoterminowe powikłania i znaczny spadek jakości życia. Wielu pacjentów zmaga się z objawami, które wpływają na ich zdolności fizyczne, poznawcze, emocje i interakcje społeczne.1

Łagodny guz mózgu może mieć głęboki wpływ na zdrowie psychiczne. W zależności od lokalizacji, guz może wpływać na regiony mózgu odpowiedzialne za regulację nastroju, prowadząc do lęku, depresji lub zmian osobowości.1

Wielu pacjentów zgłasza, że słowo „łagodny” minimalizuje ich doświadczenie. Łagodne guzy mózgu mogą wiązać się ze znacznymi wyzwaniami, które wpływają na każdy aspekt życia osoby.1

Jak opisuje jeden z pacjentów: „Uwielbiam cytat 'łagodny nie znaczy w porządku’, ponieważ sam miałem łagodny guz mózgu. Wiąże się z tym wiele problemów. Moją jedyną opcją leczenia była operacja mózgu i to była poważna sprawa. Nadal istnieją pewne problemy pooperacyjne, z którymi borykam się półtora roku po operacji – problemy z mową, problemy z równowagą, lęk i utrata pamięci krótkotrwałej. Każdego dnia nadal jest wyzwaniem radzenie sobie z zaburzeniami widzenia i migrenami. Codziennie przyjmuję leki. Mimo że był to łagodny guz mózgu i nie ma go już w moim ciele, nadal jest wiele rzeczy, na które trzeba uważać.”1

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  1. 10.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Benign (Non-Cancerous) Brain Tumors | OncoLink
    https://www.oncolink.org/cancers/brain-tumors/benign-non-cancerous-brain-tumors
    A brain tumor is a mass of cells that have grown out of control and formed in or near your brain. Brain tumors can be benign (not cancer) or malignant (cancer). Most benign tumors grow slowly and do not spread to other parts of your body. As a benign brain tumor grows, it can cause symptoms. […] Treatment for your benign brain tumor will depend on many factors such as the type of tumor, where it is, how big it is, your age, and if the tumor is causing symptoms. The most common treatments for benign brain tumors are surgery and radiation. Your provider will decide the best treatment for you. […] Benign tumors do not usually come back after surgery, but if they do radiation can be used. […] Some benign brain tumors can come back after treatment, this is called recurrence. It is important to continue your follow-up care plan.
  • #1 Brain Cancer | Nebraska Hematology Oncology – Cancer Care Treatment Blood Disorders Clinical Trials Lincoln Nebraska (NE)
    https://www.yourcancercare.com/types-of-cancer/brain-cancer
    An abnormal growth of cells in the brain is called a brain tumor. Brain tumors may be malignant (cancerous) or benign (non-cancerous). […] Brain tumors are designated as benign or malignant based on how cells from the biopsy sample appear under a microscope. Typically, benign tumors are less aggressive and more treatable than malignant tumors. […] A benign brain tumor consists of cells that have a normal or almost normal appearance when viewed under a microscope. The tumor is very slow-growing, has distinct borders that form a capsule, and does not spread into adjacent brain tissue. Benign brain tumors grow like a balloon being blown up, with an intact capsule and no direct invasion of brain tissue. However, benign brain tumors can cause brain damage or be considered life-threatening due to their ability to encroach into areas of the brain occupied by normal cells, causing increased pressure on and dysfunction in these cells. […] Surgery alone is often curative for benign tumors that are located where complete removal is possible. The most common benign brain tumors are meningiomas and neural sheath tumors (neurilemmoma).
  • #1 Non-Malignant Benign Brain Tumors | Aaron Cohen-Gadol, MD
    https://www.aaroncohen-gadol.com/en/patients/brain-tumor/types/benign
    Brain tumors are abnormal cells growing out of control within the brain. While some are malignant (cancerous and fast-growing), most are benign and non-cancerous. Benign brain tumors grow relatively slowly and tend to stay in one place. […] Tumors in the brain that are determined as benign or non-malignant tend to grow slowly and stay in one place. They dont typically spread to the surrounding normal brain tissue or the spinal cord. In most cases, they tend to not return if the entire tumor was successfully removed in surgery. […] Their growth is slow and controlled, but benign brain tumors without any symptoms must still be observed. Masses growing near or inside the skull can cause pressure on the brain, no matter their size or rate of growth. Without active surveillance and prompt treatment, the resulting intracranial pressure can cause symptoms and even become life-threatening.
  • #1 Benign brain tumors. Booking Health
    https://bookinghealth.com/blog/diagnoses-and-treatment/diagnosis-and-treatment/389911-benign-brain-tumors-can-they-be-benign-and-dangerous-at-the-same-time.html
    The attitude of patients and healthcare professionals to benign brain tumors is rather contradictory. On one hand, such tumors are not connected to the oncological process they grow slowly or even remain the same size, do not invade nearby tissues and organs, and stay at the site of origin without metastasizing. […] Even non-malignant neoplasm inside the skull is a potential cause of neurological problems. […] Although benign brain tumors are more widespread than malignant ones, their causes still need to be specified. […] Based on the information from clinical practice and some clinical trials, we should note the following risk factors: Age. The older you are, the higher the risk of developing a benign brain tumor is. […] Benign brain tumors are not dangerous themselves, as they do not invade surrounding tissues or metastasize, do not deprive healthy tissues of nutrients, remain stable and do not cause intoxication with their degradation products, do not harm blood vessels, and cause bleedings, etc. Small benign tumors are often asymptomatic and can be revealed only by accident.
  • #1 Brain Neoplasms: Practice Essentials, Pathophysiology, Etiology
    https://emedicine.medscape.com/article/779664-overview
    Tumors of the brain produce neurologic manifestations through a number of mechanisms. Small, critically located tumors may damage specific neural pathways traversing the brain. Tumors can invade, infiltrate, or supplant normal parenchymal tissue, disrupting normal function. Because the brain dwells in the limited volume of the cranial vault, growth of intracranial tumors with accompanying edema may cause increased intracranial pressure. Tumors adjacent to the third and fourth ventricles may impede the flow of cerebrospinal fluid, leading to obstructive hydrocephalus. In addition, tumors generate new blood vessels (ie, angiogenesis), disrupting the normal blood-brain barrier and promoting edema. […] The cumulative effects of tumor invasion, edema, and hydrocephalus may elevate the intracranial pressure (ICP) and impair cerebral perfusion. Intracranial compartmental rise in ICP may provoke shifting or herniation of tissue under the falx cerebri, through the tentorium cerebelli, or through the foramen magnum.
  • #1 Benign brain tumors. Booking Health
    https://bookinghealth.com/blog/diagnoses-and-treatment/diagnosis-and-treatment/389911-benign-brain-tumors-can-they-be-benign-and-dangerous-at-the-same-time.html
    Nevertheless, in certain circumstances, benign tumors influence the general state of a person, cause symptoms, and can even be life-threatening. […] The main mechanisms of harmful influence are the following: Pressure on the surrounding tissues, including vital centers. […] Increasing general volume of the brain. […] Blocking cerebrospinal fluid flow. […] Benign brain tumors can cause a bunch of general (which occur in many other diseases) and certain symptoms. This mainly depends on the localization and size of the tumor. […] We can think about benign brain tumors in the presence of such signs as; Severe recurrent headaches that worsen in the morning and do not respond to usual painkillers. […] A gradual, partial loss of hearing can be a sign of schwannoma, as this tumor involves the hearing nerve.
  • #1 Understanding Benign Tumors in Epilepsy – The Defeating Epilepsy Foundation
    https://www.defeatingepilepsy.org/living-with-epilepsy-series/benign-tumors-and-epilepsy/
    Tumor Impact on Brain Activity: While benign tumors arent cancerous, their presence in the brain can disrupt normal function. As a tumor grows, it may put pressure on nearby neurons, leading to abnormal electrical signals. This interference can irritate the brain, triggering seizures. […] Hyper-Excitable Neurons: Some benign tumors, like gangliogliomas or DNETs, are made of neuron-like cells that create an environment ripe for over-excitation. This essentially primes certain parts of the brain for seizures, with neurons firing too easily and spontaneously. […] Role of Tumor Location: The exact location of a benign tumor can significantly influence the type of seizures experienced. For example, tumors in the temporal lobe often cause focal seizures that may involve memory or emotional responses, while hypothalamic hamartomas can trigger rare seizure types like gelastic (laughing) seizure.
  • #1 Brain Tumors | Neurological Surgery | University of Pittsburgh
    https://www.neurosurgery.pitt.edu/centers/neurosurgical-oncology/brain-and-brain-tumors/brain-tumors
    Benign brain tumors do not contain cancer cells. Usually these tumors can be removed, and they are not likely to recur. Benign brain tumors have clear borders. Although they do not invade nearby tissue, they can press on sensitive areas of the brain and cause symptoms. […] The causes of brain tumors are not known. Researchers are trying to solve this problem. Thc more they can find out about the causes of brain tumors, the better the chances of finding ways to prevent them. […] By studying large numbers of patients, researchers have found certain risk factors that increase a person’s chance of developing a brain tumor. People with these risk factors have a higher-than-average risk of getting a brain tumor. […] In most cases, patients with a brain tumor have no clear risk factors. The disease is probably the result of several factors acting together.
  • #1 Meningioma: What It Is, Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17858-meningioma
    A meningioma is a tumor that forms in your meninges, which are the layers of tissue that cover your brain and spinal cord. Theyre usually not cancerous (benign), but can sometimes be cancerous (malignant). Meningiomas originate from arachnoid cells in particular, which are cells within the thin, spiderweb-like membrane that covers your brain and spinal cord. Most meningiomas arent cancerous (benign), though they can sometimes be cancerous (malignant). A benign tumor wont spread to other parts of your body. Meningiomas tend to grow slowly and inward. Often, theyll have grown quite large before theyre diagnosed. Even benign meningiomas can grow large enough to be life-threatening if they compress and affect nearby areas of your brain. In most cases, meningiomas are benign (noncancerous), but they can sometimes be cancerous (malignant). Even if a meningioma is benign, if it grows large enough, it can press on important nerves and structures of your brain, which can cause harm and even be life-threatening. Scientists dont yet know the exact cause of meningiomas. Research has shown that 40% to 80% of all meningiomas have an abnormality in chromosome 22, which is involved in the suppression of the growth of tumors. This overwhelmingly occurs spontaneously (randomly) or rarely as part of certain genetic (inherited) conditions.
  • #1 Brain Tumours: Signs, Symptoms, Types and Treatment
    https://patient.info/cancer/brain-cancer-and-brain-tumours
    The cause of most non-cancerous (benign) brain tumours and primary cancerous (malignant) brain tumours is not known. […] Genetic factors may be a risk for some people – perhaps in about 1 in 20 cases. For example, people with the hereditary diseases called neurofibromatosis type 1, Turcot’s syndrome, Li-Fraumeni cancer syndrome, and tuberous sclerosis have a higher-than-average risk of developing a glioma. […] Most gliomas occur in older adults and inherited (genetic) factors are not thought to be involved. […] Previous radiotherapy to the brain is thought to increase the risk of a brain tumour. […] Meningiomas are usually benign. They grow from cells in the tissues that surround the brain (the meninges). […] An acoustic neuroma (schwannoma) is a benign tumour which arises from Schwann cells which cover the nerve that goes to the ear. Symptoms can include deafness on the affected side and dizziness with a spinning sensation (vertigo).
  • #1 Meningioma Brain Tumor Diagnosis and Symptoms – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/neurosurgery/meningioma
    Predisposing factors associated with meningiomas include exposure to radiation, prolonged use of certain hormones and some genetic disorders (e.g., neurofibromatosis). Benign (noncancerous) meningiomas are also more common in women than men and may show increased growth during pregnancy. […] People with a genetic disorder known as neurofibromatosis type 2 (NF2) are more likely to develop meningiomas. Of people with malignant meningiomas, a higher percentage have mutations in NF2. […] Patients with NF2 are more likely to develop meningiomas because they have inherited a gene that has the potential to cause normal cells to become cancerous. […] A meningioma is a type of tumor growing near the brain. While roughly 90% of these tumors are benign, some do become cancerous.
  • #1 Meningioma – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/meningioma/symptoms-causes/syc-20355643
    A meningioma is a tumor that grows from the membranes that surround the brain and spinal cord, called the meninges. A meningioma is not a brain tumor, but it may press on the nearby brain, nerves and vessels. Meningioma is the most common type of tumor that forms in the head. […] It isn’t clear what causes a meningioma. Experts know that something changes some cells in the meninges. The changes makes them multiply out of control. This leads to a meningioma. […] Being exposed to radiation as a child is the only known environmental risk factor for getting meningioma. There’s no good evidence to show that meningiomas happen because of cellphone use. […] Risk factors for a meningioma include: Radiation therapy that involves the head may increase the risk of a meningioma. Meningiomas are more common in women. This might mean that female hormones may play a role. Some studies also have suggested a link between breast cancer and meningioma risk related to the role of hormones. Some research suggests that the use of oral birth control and hormone replacement therapy could raise the risk of meningioma growth. The rare condition neurofibromatosis 2 increases the risk of meningioma and other brain tumors. A high body mass index (BMI) is a risk factor for many types of cancers. Several large studies have found that meningiomas happen more often in obese people. But the link between obesity and meningiomas is not clear.
  • #1 What Is a Benign Brain Tumor? | Keck Medicine of USC
    https://www.keckmedicine.org/blog/what-is-a-benign-brain-tumor/
    Benign tumors make up over half of the tumors Keck Medicine of USC doctors treat. Heres what you need to know about treatment. […] While science has yet to determine exactly what causes benign brain tumors, some research has shown that in a small subset of people, there is a genetic cause. Neurofibromatosis 1, for instance, is a genetic disease that can cause benign tumors to occur in the nerves, brain and spinal cord. Children of people with this disease have a 50% chance of developing this type of benign brain tumor. […] One of the biggest risk factors for developing a benign brain tumor is radiation, Dr. Zada says. This can happen from radiation administered for another cancer or from radiation used in dental treatment. […] Another known risk factor is certain hormone therapies. If a woman, especially one who already has a meningioma, undergoes a pregnancy or hormone therapy, she can be at risk of the tumor growing or enlarging, he says. […] Just because tumors are benign does not mean they cannot be terrible diseases, says Dr. Zada. Meningioma is a great example of that. The tumor can be benign, but it can still grow in an invasive fashion. […] Benign tumors can become cancerous after prolonged years or prolonged treatment.
  • #1 Meningioma Brain Tumor: Causes, Symptoms, and Treatment
    https://www.webmd.com/cancer/brain-cancer/meningioma-causes-symptoms-treatment
    A meningioma is a tumor that forms on the membranes that cover the brain and spinal cord just inside the skull. These tumors are often slow-growing. Around 80% are benign (not cancerous). […] About 80% of grade 1 tumors are benign (not cancerous). They grow slowly and have defined borders. […] Researchers are unsure what exactly causes meningioma, but cancers generally result from changes in our genes. Researchers have found an abnormality on chromosome 22, which works to keep tumors from growing, in about 40%-80% of meningiomas. […] Meningiomas are more common in women and people assigned female at birth (AFAB), and middle-aged women are more than twice as likely as men to develop a meningioma. […] The hormones estrogen, progesterone, and androgen are believed to play a role in meningioma. Meningioma cell surfaces have receptors for estrogen, progesterone, or both. Meningiomas grow more rapidly in pregnancy when the body naturally creates more of these hormones.
  • #1 About Brain Tumours | Spinal Cord Tumours | Cancer Council NSW
    https://www.cancercouncil.com.au/brain-cancer/about-brain-tumours/
    A brain or spinal cord tumour starts when abnormal cells grow and form a mass or lump. The tumour may be benign or malignant, but both types can be serious and may need urgent treatment. […] Brain tumours are often classified as benign or malignant. These terms are also used for tumours in other parts of the body. But with brain tumours the difference is not as clear. […] Many benign brain tumours grow slowly and are less likely to spread or grow back (if all of the tumour can be successfully removed). But a benign tumour may still affect how the brain works. This can be life-threatening and need urgent treatment. Sometimes a benign tumour can change over time and become malignant or more aggressive. […] The cause of most brain and spinal cord tumours is unknown. As we get older the risk of developing many cancers, including brain cancer, increases.
  • #1 Meningioma Brain Tumor Diagnosis and Symptoms – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/neurosurgery/meningioma
    Meningiomas are tumors that develop from the membrane (meninges) that covers the brain and spinal cord. They are the most common primary brain tumor in adults. Most meningioma tumors (85-90%) are categorized as benign, with the remaining 10-15% being atypical meningioma or malignant meningioma (cancerous). […] The word benign can be misleading for meningiomas. Depending on location and growth rate, a benign meningioma brain tumor may impinge on vital nerves or compress the brain, causing disability. They may even become life threatening. […] Meningiomas occur most commonly in people aged 40 to 70 years and occur more commonly in women. They are found in about 3% of people over age 60. The few known predisposing factors are prior radiation exposure, prolonged hormone use and genetically inherited conditions such as neurofibromatosis type 2.
  • #1 How Serious Is a Brain Tumor? | Tisch Brain Tumor Center
    https://tischbraintumorcenter.duke.edu/blog/how-serious-brain-tumor
    Brain tumors are a multifaceted medical condition that can vary significantly in terms of their seriousness. These abnormal growths of cells within the brain can be classified into two categories, benign (non-cancerous) or malignant (cancerous). […] These tumors are typically slow-growing and have clear borders. They are not known to invade nearby tissues and are less likely to recur after treatment. […] Pituitary adenomas are benign tumors that develop in the pituitary gland, a small gland at the base of the brain. […] Craniopharyngiomas are benign tumors that develop near the pituitary gland and the hypothalamus. […] Schwannomas are benign tumors from the nerve connecting the ear to the brain. […] Nasopharyngeal angiofibroma is a rare, non-cancerous tumor that typically occurs in adolescent boys.
  • #1 How Serious Is a Brain Tumor? | Tisch Brain Tumor Center
    https://tischbraintumorcenter.duke.edu/blog/how-serious-brain-tumor
    Choroid plexus tumors are rare, benign tumors that develop in the choroid plexus of the brain, which is responsible for cerebrospinal fluid (CSF) production. […] DNET is a rare, benign tumor that mainly affects children and young adults. […] Neurofibromas are benign tumors that originate from nerve tissue. […] Hemangioblastomas are benign tumors that most commonly develop in the cerebellum, a part of the brain responsible for coordination. […] Chondromas are slow-growing benign tumors that originate from cartilage tissue. […] Giant cell tumors are made up of large cells and can develop in the skull, legs, or arm bones. […] Osteomas are benign bone tumors that can develop in the skull or facial bones.
  • #1 Low grade brain tumours | The Brain Tumour Charity
    https://www.thebraintumourcharity.org/brain-tumour-diagnosis-treatment/how-brain-tumours-are-diagnosed/how-brain-tumours-are-graded/low-grade-brain-tumours/
    Low grade brain tumours are grade 1 or grade 2 tumours and are sometimes called benign brain tumours. They are usually slow growing and unlikely to spread. But, they can still be serious. […] Low grade tumours are sometimes called benign brain tumours. But, the term benign brain tumour is used less frequently nowadays as it can be misleading. […] Although low grade brain tumours grow more slowly than high grade tumours, they can still be serious. […] This is because the tumour can cause harm by pressing on and damaging nearby areas of the brain, due to the limited space capacity of the skull. They can also block the flow of the cerebrospinal fluid (CSF) that nourishes and protects the brain, causing a build-up of pressure on the brain.
  • #1 Non-Malignant Benign Brain Tumors | Aaron Cohen-Gadol, MD
    https://www.aaroncohen-gadol.com/en/patients/brain-tumor/types/benign
    Some non-malignant brain tumors may need to be removed surgically. Even a non-cancerous mass growing inside the head can be dangerous, as there is only so much room inside the skull for anything other than the brain. A slow-growing tumor may eventually create significant pressure on the brain that can cause symptoms and become life-threatening. […] The goal of operating on benign brain tumors is to safely remove as much of the mass as possible. In cases where the tumor is located deep inside the brain or near sensitive structures, only part of the tumor may be safely removed. The remaining cells are managed through observation, chemotherapy or radiotherapy. […] If none or only a part of the tumor can be safely removed through surgery, chemotherapy and radiotherapy may be used. Often, the remaining benign tumor cells after surgery are monitored and treated via chemotherapy and radiation if further growth is noted on follow-up imaging.
  • #1 Meningioma Brain Tumor: Causes, Symptoms, and Treatment
    https://www.webmd.com/cancer/brain-cancer/meningioma-causes-symptoms-treatment
    Meningiomas usually grow slowly, so their symptoms often develop gradually, if they develop at all. […] A meningioma is a tumor that grows on the membranes just inside your skull that cover the brain and spinal cord, known as the meninges. Meningiomas usually grow slowly, sometimes developing for years before you feel any symptoms. Around 80% of meningiomas are noncancerous (benign), but they can cause changes to your senses, memory, and neurological functions. […] Meningioma is a type of tumor that grows on the membranes between the skull and the brain and spinal cord. Technically, they are not tumors in your brain, but their growth can press against nearby brain tissue, nerves, and blood vessels, causing symptoms. Meningioma is the most common head tumor. Around 80% of meningiomas are not cancerous. […] Doctors aren’t sure what causes meningiomas, but it’s believed that many or most are genetic in origin and some may be related to hormones or particular environmental factors.
  • #1 Non-Malignant Benign Brain Tumors | Aaron Cohen-Gadol, MD
    https://www.aaroncohen-gadol.com/en/patients/brain-tumor/types/benign
    However, some cases do not necessarily require surgery, chemotherapy, or radiotherapy. For example, an older patient with a small brain tumor may simply be monitored with yearly MRIs to ensure it is not growing. […] While some non-cancerous tumors go away entirely after being treated, some can recur or even become cancerous. This is why its crucial that you work with your physician/surgeon and speak to them about any new or worsening symptoms you may experience.
  • #1
    https://111.wales.nhs.uk/braintumour,benign/
    If all of the tumour cannot be removed, other treatments, such as radiotherapy and chemotherapy, may be needed to control the growth of the remaining abnormal cells. […] Rarely, some slow-growing non-cancerous tumours grow back after treatment and can change into malignant brain tumour (brain cancer) which are fast-growing and likely to spread.
  • #1 Are All Brain Tumors Cancerous? | Appledore Medical Group
    https://appledoremedicalgroup.com/blog/entry/are-all-brain-tumors-cancerous-
    To many, the mention of a brain tumor brings about a dire image, but a brain tumor does not always mean a cancer diagnosis. A tumor is a mass of abnormally dividing cells, and is either considered benign or malignant: […] Benign tumors are slow growing, well-defined tumors that do not spread to other parts of the body. […] Because they do not invade the surrounding tissue, benign tumors are relatively easy to remove with surgery, depending on their location. […] In some cases, benign tumors may become malignant, though this usually takes a long time, sometimes decades, if it happens at all. […] Benign tumors generally do not cause death or serious illness unless they are very large, such as some benign ovarian tumors, or if they affect a critical organ that makes it difficult to operate on and remove them, such as tumors in the brain.
  • #1 If a Brain Tumor is Not Cancerous, Why Do Anything About It? | Roswell Park Comprehensive Cancer Center – Buffalo, NY
    https://www.roswellpark.org/cancertalk/201805/if-brain-tumor-not-cancerous-why-do-anything-about-it
    Even a benign tumor that’s growing inside the head is potentially dangerous,” says Robert Fenstermaker, MD, Chair of Neurosurgery at Roswell Park Comprehensive Cancer Center. „There’s only so much room inside the skull, and the brain occupies most of it. Even if a brain tumor is benign and growing slowly, eventually the brain won’t be able to tolerate that, and symptoms will develop, which can be life-threatening. […] Most benign tumors are treated with surgery, focused radiation or a combination of the two. Increasingly, we’re finding that a combination is better than either one by itself. If a tumor is large, it’s hard to treat it with just radiation therapy. Surgery will help reduce the tumor’s size, says Dr. Fenstermaker. […] At the same time, it may not be safe to remove the entire tumor. It could be touching or encasing blood vessels or other critical structures, such as nerves, and trying to remove the entire tumor could damage those structures. What we’re doing is reducing the size of those tumors with surgery and then treating them with focused radiation, such as Gamma Knife radiotherapy, to control what’s left.
  • #1 If a Brain Tumor is Not Cancerous, Why Do Anything About It? | Roswell Park Comprehensive Cancer Center – Buffalo, NY
    https://www.roswellpark.org/cancertalk/201805/if-brain-tumor-not-cancerous-why-do-anything-about-it
    Most patients see an improvement in their symptoms shortly after treatment of their benign tumors. „The vast majority of people who have their brain tumors removed function better after treatment than before,” says Dr. Fenstermaker. „There are risks to vital neurologic functions that can’t be reduced to zero, but the modern treatment of brain tumors is a great advance, and it greatly benefits most patients.”
  • #1 Benign is Not “Fine”: Common Misconceptions About Noncancerous Brain Tumors
    https://braintumor.org/news/benign-is-not-fine-common-misconceptions-about-noncancerous-brain-tumors/
    A benign brain tumor involves abnormal growths in the brain that can disrupt essential functions. These tumors can press on critical areas, causing debilitating symptoms, long-term complications, and a significant decline in quality of life. Many patients struggle with symptoms that affect their physical abilities, cognition, emotions, and social interactions. […] Just because it was benign doesn’t mean it wasn’t bad, said Lisa G., who had subependymal giant cell astrocytoma. I was experiencing intermittent vision loss, lethargy, debilitating headaches, mood swings, flu-like symptoms (hot/cold), poor concentration, and focus. […] For many patients, managing a benign brain tumor involves treatment, which may include surgery, radiation, and/or medication. While serious complications are rare, every patient’s journey is unique, and recovery can look different for everyone.
  • #1 Benign is Not “Fine”: Common Misconceptions About Noncancerous Brain Tumors
    https://braintumor.org/news/benign-is-not-fine-common-misconceptions-about-noncancerous-brain-tumors/
    A benign brain tumor can have a profound impact on mental health. Depending on its location, the tumor may affect brain regions responsible for mood regulation, leading to anxiety, depression, or personality changes. […] Many patients report that the word benign minimizes their experience. Benign brain tumors can come with significant challenges that affect every aspect of a person’s life. […] I love the quote benign is not fine because I myself have had a benign brain tumor. There’s a lot that comes with that. My only option for treatment was brain surgery, and it was a big deal. There are still some post-op things that I’m dealing with a year and a half out from surgery speech dilemmas, balance issues, anxiety, and short-term memory loss. It’s still a challenge every day to get through with visual disturbances and migraines. I’m on medications daily. Even though it was a benign brain tumor, and it’s no longer in my body, there’s still a lot to keep on top of.
  • #2 Non-Malignant Benign Brain Tumors | Aaron Cohen-Gadol, MD
    https://www.aaroncohen-gadol.com/en/patients/brain-tumor/types/benign
    Brain tumors are abnormal cells growing out of control within the brain. While some are malignant (cancerous and fast-growing), most are benign and non-cancerous. Benign brain tumors grow relatively slowly and tend to stay in one place. […] Tumors in the brain that are determined as benign or non-malignant tend to grow slowly and stay in one place. They dont typically spread to the surrounding normal brain tissue or the spinal cord. In most cases, they tend to not return if the entire tumor was successfully removed in surgery. […] Their growth is slow and controlled, but benign brain tumors without any symptoms must still be observed. Masses growing near or inside the skull can cause pressure on the brain, no matter their size or rate of growth. Without active surveillance and prompt treatment, the resulting intracranial pressure can cause symptoms and even become life-threatening.
  • #2 Are All Brain Tumors Cancerous? | Appledore Medical Group
    https://appledoremedicalgroup.com/blog/entry/are-all-brain-tumors-cancerous-
    Brain tumors are described differently than tumors found in other parts of the body. A benign tumor will not spread to other parts of the body, but that does not mean that it is harmless. It can still grow and put pressure on tissue in the brain. This pressure can cause damage to healthy brain tissue and interrupt normal functions of the brain. […] Cell division and cell death are a normal process in the body to replace old or damaged cells. Sometimes this division and new cell growth can continue after it is supposed to stop. This excess growth forms a tumor. Benign tumors grow in the area, but do not invade nearby tissue. […] It is not always clear what causes the abnormal growth, but it often is a combination of genetic and environmental factors. […] Most benign brain tumors are treatable. Treatment options are similar to other brain tumor treatments, and are based on the patient’s age and overall health, and the location and size of the tumor. Typically, chemotherapy is not recommended in cases of benign brain tumors.
  • #2 Benign brain tumors. Booking Health
    https://bookinghealth.com/blog/diagnoses-and-treatment/diagnosis-and-treatment/389911-benign-brain-tumors-can-they-be-benign-and-dangerous-at-the-same-time.html
    The attitude of patients and healthcare professionals to benign brain tumors is rather contradictory. On one hand, such tumors are not connected to the oncological process they grow slowly or even remain the same size, do not invade nearby tissues and organs, and stay at the site of origin without metastasizing. […] Even non-malignant neoplasm inside the skull is a potential cause of neurological problems. […] Although benign brain tumors are more widespread than malignant ones, their causes still need to be specified. […] Based on the information from clinical practice and some clinical trials, we should note the following risk factors: Age. The older you are, the higher the risk of developing a benign brain tumor is. […] Benign brain tumors are not dangerous themselves, as they do not invade surrounding tissues or metastasize, do not deprive healthy tissues of nutrients, remain stable and do not cause intoxication with their degradation products, do not harm blood vessels, and cause bleedings, etc. Small benign tumors are often asymptomatic and can be revealed only by accident.
  • #2 Overview of Intracranial Tumors – Neurologic Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/neurologic-disorders/intracranial-and-spinal-tumors/overview-of-intracranial-tumors
    Some tumors are benign, but because the cranial vault allows no room for expansion, even benign tumors can cause serious neurologic dysfunction or death. […] Benign tumors grow slowly. They may become quite large before causing symptoms, partly because often there is no cerebral edema. Malignant primary tumors grow rapidly but rarely spread beyond the CNS. Death results from local tumor growth and/or tumor-related hemorrhage and thus can result from benign as well as malignant tumors.
  • #2 Meningioma Brain Tumor: Causes, Symptoms, and Treatment
    https://www.webmd.com/cancer/brain-cancer/meningioma-causes-symptoms-treatment
    A meningioma is a tumor that forms on the membranes that cover the brain and spinal cord just inside the skull. These tumors are often slow-growing. Around 80% are benign (not cancerous). […] About 80% of grade 1 tumors are benign (not cancerous). They grow slowly and have defined borders. […] Researchers are unsure what exactly causes meningioma, but cancers generally result from changes in our genes. Researchers have found an abnormality on chromosome 22, which works to keep tumors from growing, in about 40%-80% of meningiomas. […] Meningiomas are more common in women and people assigned female at birth (AFAB), and middle-aged women are more than twice as likely as men to develop a meningioma. […] The hormones estrogen, progesterone, and androgen are believed to play a role in meningioma. Meningioma cell surfaces have receptors for estrogen, progesterone, or both. Meningiomas grow more rapidly in pregnancy when the body naturally creates more of these hormones.
  • #2 Meningioma Brain Tumor Diagnosis and Symptoms – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/neurosurgery/meningioma
    Predisposing factors associated with meningiomas include exposure to radiation, prolonged use of certain hormones and some genetic disorders (e.g., neurofibromatosis). Benign (noncancerous) meningiomas are also more common in women than men and may show increased growth during pregnancy. […] People with a genetic disorder known as neurofibromatosis type 2 (NF2) are more likely to develop meningiomas. Of people with malignant meningiomas, a higher percentage have mutations in NF2. […] Patients with NF2 are more likely to develop meningiomas because they have inherited a gene that has the potential to cause normal cells to become cancerous. […] A meningioma is a type of tumor growing near the brain. While roughly 90% of these tumors are benign, some do become cancerous.
  • #2 How Serious Is a Brain Tumor? | Tisch Brain Tumor Center
    https://tischbraintumorcenter.duke.edu/blog/how-serious-brain-tumor
    Choroid plexus tumors are rare, benign tumors that develop in the choroid plexus of the brain, which is responsible for cerebrospinal fluid (CSF) production. […] DNET is a rare, benign tumor that mainly affects children and young adults. […] Neurofibromas are benign tumors that originate from nerve tissue. […] Hemangioblastomas are benign tumors that most commonly develop in the cerebellum, a part of the brain responsible for coordination. […] Chondromas are slow-growing benign tumors that originate from cartilage tissue. […] Giant cell tumors are made up of large cells and can develop in the skull, legs, or arm bones. […] Osteomas are benign bone tumors that can develop in the skull or facial bones.
  • #2 Haemangioblastoma | Brain (and spinal cord) tumours | Cancer Research UK
    https://www.cancerresearchuk.org/about-cancer/brain-tumours/types/haemangioblastoma
    Haemangioblastomas are rare non cancerous (benign) brain tumours. They start in the cells that line the blood vessels in the brain, spinal cord and brain stem. They usually grow slowly over some years. […] Some haemangioblastomas happen because of a rare inherited syndrome called von Hippel-Lindau syndrome. People with this syndrome have a higher risk of developing different types of tumours, including haemangioblastoma. […] Surgery is the main treatment for haemangioblastoma. A brain specialist surgeon (neurosurgeon) removes all the tumour or just a part. This depends on where the tumour is. […] Doctors are always trying to improve the diagnosis and treatment of brain tumours. As part of your treatment, your doctor might ask you to take part in a clinical trial. This might be to test a new treatment or look at different combinations of existing treatments.