Materiały źródłowe

• #1 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079

  Paget’s disease of the breast affects your nipple and usually the skin (areola) surrounding it. It’s easy to mistake the signs and symptoms of Paget’s disease of the breast for skin irritation (dermatitis) or another noncancerous (benign) skin condition. […] Possible signs and symptoms of Paget’s disease of the breast include: Flaky or scaly skin on your nipple, Crusty, oozing or hardened skin resembling eczema on the nipple, areola or both, Itching, Redness, A tingling or burning sensation, Straw-colored or bloody nipple discharge, A flattened or turned-in (inverted) nipple, A lump in the breast, Thickening skin on the breast. […] Signs and symptoms usually occur in one breast only. The disease typically starts in the nipple and may spread to the areola and other areas of the breast. […] On average, signs and symptoms occur for several months before a diagnosis is made.

• #2 Paget Disease of the Breast – NCI

  https://www.cancer.gov/types/breast/paget-breast-fact-sheet

  What are the symptoms of Paget disease of the breast? The symptoms of Paget disease of the breast are often mistaken for those of some benign skin conditions, such as dermatitis or eczema. These symptoms may include the following: Itching, tingling, or redness in the nipple and/or areola […] Flaking, crusty, or thickened skin on or around the nipple […] A flattened nipple […] Discharge from the nipple that may be yellowish or bloody. Because the early symptoms of Paget disease of the breast may suggest a benign skin condition, and because the disease is rare, it may be misdiagnosed at first. People with Paget disease of the breast have often had symptoms for several months before being correctly diagnosed.

• #3 Paget’s Disease of the Breast: Stages, Symptoms & Prognosis

  https://my.clevelandclinic.org/health/diseases/17913-pagets-disease-of-the-breast

  Paget’s disease of the breast resembles eczema on your nipple and may be mistaken for an ordinary rash at first. It may cause itching and scaling, red or raised plaques on your skin and discharge from the nipple. Most people who have these symptoms dont have Paget’s disease. However, if you do, these may be the first noticeable signs of underlying breast cancer. […] Symptoms affect your nipple and/or areola. They usually only affect one breast, but rarely, they may affect both. They may appear to come and go at first but eventually worsen. Symptoms can include: Nipple itching that can turn to burning. Dry skin, flaking or scaling of the nipple or areola. Skin rash that might be red, raised, crusting, raw or bleeding. Inflammation and soreness. Crusting and oozing resembling weeping eczema. Bloody or pus-like nipple discharge. Flat or inverted nipple. Palpable breast lump under the skin.

• #3 Paget’s Disease of the Breast: Stages, Symptoms & Prognosis

  https://my.clevelandclinic.org/health/diseases/17913-pagets-disease-of-the-breast

  If you only have Paget’s disease of the nipple or ductal carcinoma in situ (stage 0) that hasnt spread beyond the milk ducts, your prognosis is excellent. Most people who discover and treat these conditions early will make a full recovery. Once breast cancer begins to spread, it becomes progressively harder to beat.

• #4 Paget’s Disease of the Breast: Symptoms, Diagnosis, Treatment, and Prevention

  https://www.webmd.com/breast-cancer/pagets-nipple-disease

  Early symptoms include redness, light scaling, and flaking of the skin on your nipple. You might have only mild irritation, not enough to send you to the doctor. Your skin could get better on its own. This doesnt mean the disease has gone away. […] Further symptoms can be a sign of serious damage to your skin. You might notice: Tingling, Itching, More sensitivity, Burning, Pain, Bloody or yellowish discharge from your nipple, Oozing or bleeding areas, A nipple that looks flattened against your breast, Thickened skin in the nipple area, A lump or mass in your breast. […] In most cases, the disease starts in the nipple and then spreads to the areola (the circular area of darker skin that surrounds it) or other areas of your breast. Sometimes, it affects only the areola, where it can look like eczema, an itchy red rash. […] Rarely, this condition can affect both breasts.

• #5 What were your Pagets symptoms? — Community Discussion Forums

  https://community.breastcancer.org/en/discussion/869894/what-were-your-pagets-symptoms

  Just searching for advice- Ive been worrying about Pagets for a few months but primary care doctor and OB does not seem to believe anything is wrong. It started last August when my left nipple was scabbing- it was yellow/whitish tinge and wouldnt actively discharge but when I looked at my nipple it just looked like a little scab. […] The only other symptom I noticed was that my left nipple always seemed harder or more erect than the right. […] My Paget’s started with some light crusting at the center of the nip – almost like dry skin cells. I’d scrape them away. Then I noticed a little injury to the side with oozing (I thought I must have scraped it on my watch or something). […] Then there was a red itchy spot. All this happened over the course of a few years. Then it sped up – the red spot grew, over the course of several months, to double the size (about the size of a dime). […] Itchiness, pin-prick sensations, pink/red skin with defined borders, and nip receeding more were my main clues. […] I notice my nipple was red ,rash and scabbing few years back but I did nt take it serious. […] I heard paget cancer is very easy to miss diagnost by the Dr.

• #6 Mammary Paget’s Disease: An Update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9139704/

  Mammary Pagets disease is reported in 13% of all primary breast cancers. Between 90-100% of MPD cases are associated with underlying breast cancer, commonly central and multifocal tumors, mainly located near the areola. MPD can be divided into three different categories based on the presence or extent of associated disease: (1) MPD of the nipple without DCIS, (2) MPD of the nipple with DCIS in the underlying lactiferous ducts within 2 cm of the nipple, and (3) MPD of the nipple with DCIS in the underlying lactiferous ducts and associated DCIS or invasive breast cancer elsewhere in the breast extending 2 cm from the nipple-areolar complex. More than 90% of cases are associated with underlying DCIS or invasive ductal carcinoma (IDC). Initially, MPD develops insidiously, gradually evolving over months to years as it extends from the nipple into the areola in a centrifugal growth pattern. Typically, MPD presents clinically as a unilateral rash of the nipple and areola that in more advanced cases may also involve the periareolar skin. Skin rashes can range up to 15 cm in diameter. MPD skin changes of the nipple and/or areola may resemble eczema with a fine scaling erythematous rash or a flaky, fissured, bleeding rash in more established cases. Advanced cases are often accompanied by skin ulceration and nipple retraction. In 98% (217) of the patients, the main presenting symptom was eczema or ulceration of the nipple. In the early stages, however, the nipple appears to be normal, but the patient might present with mild symptoms such as nipple pruritus. MPD-associated skin surface changes slowly progress, producing a dermatitictous appearance affecting the nipple, areola, and eventually the skin of the breast. Commonly, MPD is initially misdiagnosed as eczema, dermatitis, or psoriasis, which accounts for the frequent delay in diagnosis. Consequently, to avoid a delayed diagnosis, any suspected signs or symptoms of eczematoid, pigmented, crusted, or scaly lesions or chronic inflammation in the nipple should be confirmed with biopsy. Patients with misdiagnosed MPD often receive extended courses of a topical treatment without significant improvement, which further delays diagnosis, although transient responses may be observed at the margins of the skin lesion. Thus, awareness and detailed physical examination are pivotal to distinguishing MPD from other benign (e.g., psoriasis, dermatitis, chronic eczema, lactiferous duct ectasia, or adenomatosis of the nipple) or malignant conditions (e.g., cutaneous extension of breast carcinoma, Bowens disease, basal cell carcinoma, or melanoma) involving the nipple-areolar complex. Without treatment, the skin lesions and underlying disease will progress to the development of invasive breast cancer, potentially followed by lymph node and visceral metastasis. The presence of a palpable breast tumor, lymph node enlargement, high nuclear grade, and age below 60 years are unfavorable prognostic factors that correlate with a high risk of invasive carcinoma and a high rate of lymph node metastasis.

• #7 Mammary Paget’s Disease: An Update

  https://www.mdpi.com/2072-6694/14/10/2422

  Mammary Paget’s Disease is a non-invasive cutaneous malignancy of the breast involving the nipple-areolar complex that is commonly mistaken for benign breast conditions, leading to delay in diagnosis. […] Initially, MPD develops insidiously, gradually evolving over months to years as it extends from the nipple into the areola in a centrifugal growth pattern. Typically, MPD presents clinically as a unilateral rash of the nipple and areola that in more advanced cases may also involve the periareolar skin. Skin rashes can range up to 15 cm in diameter. MPD skin changes of the nipple and/or areola may resemble eczema with a fine scaling erythematous rash or a flaky, fissured, bleeding rash in more established cases. Advanced cases are often accompanied by skin ulceration and nipple retraction.

• #7 Mammary Paget’s Disease: An Update

  https://www.mdpi.com/2072-6694/14/10/2422

  In 98% (217) of the patients, the main presenting symptom was eczema or ulceration of the nipple. […] In the early stages, however, the nipple appears to be normal, but the patient might present with mild symptoms such as nipple pruritus. MPD-associated skin surface changes slowly progress, producing a dermatitictous appearance affecting the nipple, areola, and eventually the skin of the breast. […] Commonly, MPD is initially misdiagnosed as eczema, dermatitis, or psoriasis, which accounts for the frequent delay in diagnosis. […] Thus, awareness and detailed physical examination are pivotal to distinguishing MPD from other benign (e.g., psoriasis, dermatitis, chronic eczema, lactiferous duct ectasia, or adenomatosis of the nipple) or malignant conditions (e.g., cutaneous extension of breast carcinoma, Bowen’s disease, basal cell carcinoma, or melanoma) involving the nipple-areolar complex. […] Without treatment, the skin lesions and underlying disease will progress to the development of invasive breast cancer, potentially followed by lymph node and visceral metastasis.

• #8 Paget’s Disease of the Breast: Symptoms, Treatment & Prognosis

  https://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/pagets-disease-of-the-breast

  In most cases, Pagets disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions. […] Patients may notice: Patches of thickened skin on the nipple or surrounding skin, Itching or tingling in the nipple or areola, Yellow or bloody discharge in the nipple or areola, A nipple that looks flaky, crusty or red, A nipple that appears to be flattened or inverted, meaning it caves inward.

• #9 Paget’s Disease of the Breast: Causes, Symptoms, and Treatments | SELF

  https://www.self.com/story/pagets-disease-of-the-breast

  Paget’s disease of the breast affects your nipple and usually the skin (areola) surrounding it. It’s easy to mistake the signs and symptoms of Paget’s disease of the breast for skin irritation (dermatitis) or another noncancerous (benign) skin condition. […] Possible signs and symptoms of Paget’s disease of the breast include: Flaky or scaly skin on your nipple, Crusty, oozing, or hardened skin resembling eczema on the nipple, areola, or both, Itching, Redness, A tingling or burning sensation, Straw-colored or bloody nipple discharge, A flattened or turned-in (inverted) nipple, A lump in the breast, Thickening skin on the breast. […] Signs and symptoms usually occur in one breast only. The disease typically starts in the nipple and may spread to the areola and other areas of the breast. […] The skin changes may come and go early on, or respond to topical treatment, making it appear as if your skin is healing. On average, women experience signs and symptoms for several months before getting a diagnosis.

• #10

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/pagets-disease-breast

  Early symptoms of Pagets disease of the breast might be subtle and easily ignored. Regular self-exams and monitoring for any changes in the skin of your nipple and areola can aid in early detection, improving the chances of successful treatment. […] Here are the main signs to look out for: Skin changes in the nipple and areola: You might see redness, flaking or crusting of the skin on your nipple and areola. These symptoms can be mistaken for eczema but dont improve with typical skin treatments. […] Nipple discharge: There may be a yellowish or bloody discharge from your nipple. […] Persistent itching or tingling: A continuous itching or tingling sensation in the nipple and areola area can be a warning sign. […] Nipple retraction: The nipple might become flattened or turned inward.

• #10

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/pagets-disease-breast

  Breast lump or thickening: Sometimes, there can be a palpable lump in the breast, suggesting an underlying mass. […] The progression of Paget’s disease of the breast can vary widely. It can develop slowly over several months or years. It can also progress more quickly, especially if associated with underlying invasive breast cancer.

• #11

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/pagets-disease-breast

  How fast Paget’s disease of the breast occurs varies per person. In some cases, it can develop slowly over several months or even years. For others, it may progress more rapidly, particularly if there’s an underlying invasive breast cancer. The initial skin changes might seem minor and easily overlooked, which is why many people don’t seek medical advice until the condition has advanced. Regular breast self-exams and being aware of any changes in your breast skin and nipple can help in catching the disease early.

• #12 Paget’s Disease of the Nipple | Magee-Women’s Hospital

  https://www.upmc.com/locations/hospitals/magee/services/magee-womens-cancers/breast-cancer-program/types-of-breast-cancer/pagets-disease

  Pagets disease causes skin issues like flaking and puckering. It may also cause nipple sensitivity and discharge, too. […] Pagets disease can cause nipple flattening, sensitivity, discharge, scaling, and flaking. It’s often mistaken for other skin conditions like eczema. […] Symptoms of Paget’s disease of the nipple include: Crusty, flaky, scaly, or thickened skin on or around the nipple or areola. Itching, tingling, or redness in the nipple or areola. Nipple flattening or a nipple that turns inward. Nipple or areola dimpling, puckering, or having an orange peel texture. Yellowish or bloody discharge from the nipple. […] It’s especially important to schedule an appointment if: Treatment for a skin condition on your breast, such as eczema, isn’t working. Treatment for mastitis isn’t working. You’ve noticed any new changes to your nipple or areola, such as scaling or discharge.

• #12 Paget’s Disease of the Nipple | Magee-Women’s Hospital

  https://www.upmc.com/locations/hospitals/magee/services/magee-womens-cancers/breast-cancer-program/types-of-breast-cancer/pagets-disease

  The goal of treatment for Pagets disease is to remove as much of the cancer as possible and to prevent cancer cells from spreading. […] Doctors often treat Paget’s disease with radiation therapy, which uses high-energy rays to destroy cancer cells. Radiation therapy reduces the odds that cancer will come back. […] Your recovery from Paget’s disease of the nipple will depend on the type of treatment you received. It usually takes several months to recover from surgery. It can take months to recover from chemotherapy and radiation, too. These treatments may make you tired and weak and cause side effects like nerve damage and swelling (lymphedema).

• #13

  https://www.nhs.uk/conditions/pagets-disease-nipple/

  Paget’s disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. […] The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated. […] Around half of all women diagnosed with Paget’s disease of the nipple have a lump behind the nipple. In 9 out of 10 cases this is an invasive breast cancer. […] Some women with Paget’s disease have invasive breast cancer but do not have a lump. […] However, most women with Paget’s disease who do not have a lump have non-invasive cancer. This is where the cancerous cells are contained in 1 or more areas of the breast and have not spread.

• #14 Difference Between Paget Disease and Eczema: Symptoms, Pictures, More

  https://www.healthline.com/health/womens-health/difference-between-pagets-disease-and-eczema

  Paget disease of the breast starts in the nipple and then spreads to the areola and breast skin. About 1 in 2 people with Paget disease of the breast have a lump behind the nipple. […] Symptoms of Paget disease are described below: Initial symptoms Advanced symptoms red, scaly rash on the nipple and areola flattened or retracted nipple small bumps on the nipple and sometimes the areola ulcerated nipple sore, inflamed skin bleeding from the nipple itching pain tingling or burning sensation nipple discharge. […] Early symptoms of Paget disease may be similar to those of eczema, but there are key differences that could help determine the proper diagnosis. […] Paget disease is usually diagnosed in females ages 50 years and older. Its very rare in males. […] Rarely, Paget disease of the breast involves just the skin. But about 9 in 10 cases involve ductal carcinoma in situ (DCIS) or invasive breast cancer.

• #15 Mammary Paget disease. Paget disease of the nipple

  https://dermnetnz.org/topics/mammary-paget-disease

  Mammary Paget disease typically starts as an eczema-like change of one nipple, extending with time over the areola, and often associated with an underlying breast lump. It is rarely bilateral. Ectopic and accessory nipples can be affected. […] Common cutaneous features of mammary Paget disease include: Eczematous or psoriasis-like change, Well-defined but irregularly shaped red patch that slowly enlarges and can reach up to 15 cm in diameter, May be scaly and/or crusted, Initially asymptomatic, the nipple can become itchy, painful, or feel a burning sensation, With time, the nipple may become thickened and/or retracted, Ulceration, bleeding, and discharge may develop. […] Despite the visible lesion, a delay in presentation or diagnosis is common. On average, diagnosis is made 12 months after onset in women and 89 months in men. Prognosis is therefore not as good as for more common forms of breast cancer. It is particularly poor for males, with a 20-30% five-year survival.

• #16 Paget’s disease of the breast | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/breast-cancer/pagets-disease-of-the-breast

  Pagets disease of the breast is a condition that causes a scaly rash on the skin of the nipple. This can look like eczema. […] The first symptom of Paget’s disease is usually a red scaly, rash on the nipple. This might be harder to see if you have black or brown skin. The skin in the area may look darker than your usual skin tone. […] It may also affect the dark area of skin surrounding the nipple (the areola). This can happen after you have had the nipple rash for a few weeks. The rash does not go away, and it may become sore. Pagets disease usually only affects 1 nipple. […] Other symptoms may include: the skin of the nipple and areola becoming inflamed, the skin of the nipple and areola crusting, bleeding and ulcerating (becoming like an ulcer), skin thickening on the nipple or areola, an itching or burning sensation in the area, fluid (discharge) leaking from the area, the nipple turning inwards (becoming inverted). […] There may or may not be a lump in the breast. About half of women with Pagets disease (50%) have a breast lump that they can feel at diagnosis.

• #17 Paget’s disease of the breast

  https://johnsonmemorial.org/jmh-health/disease-conditions/con-20155351

  Paget’s disease of the breast affects your nipple and usually the skin (areola) surrounding it. It’s easy to mistake the signs and symptoms of Paget’s disease of the breast for skin irritation (dermatitis) or another noncancerous (benign) skin condition. […] Possible signs and symptoms of Paget’s disease of the breast include: Flaky or scaly skin on your nipple, Crusty, oozing or hardened skin resembling eczema on the nipple, areola or both, Itching, Redness, A tingling or burning sensation, Straw-colored or bloody nipple discharge, A flattened or turned-in (inverted) nipple, A lump in the breast, Thickening skin on the breast. […] Signs and symptoms usually occur in one breast only. The disease typically starts in the nipple and may spread to the areola and other areas of the breast. […] The skin changes may come and go early on or respond to topical treatment, making it appear as if your skin is healing. On average, signs and symptoms occur for several months before a diagnosis is made.

• #18 Pagets Disease | St Marks – Breast Centre of Excellence

  https://smwh.co.nz/breast-cancer/breast-cancer-types/pagets-disease/

  Paget disease of the nipple is an uncommon type of cancer that forms in or around the nipple where the nipple may bleed or ulcerate. […] One of the first symptoms of Pagets disease is an eczema-like rash on and around the nipple, where the skin itchy, red and inflamed. There may be some discharge, and the nipple may turn inwards. With Pagets disease, a lump in the breast may or may not be present, along with a sore that does not heal. […] The symptoms of Pagets disease normally begin with the nipple and then spread, and often will disappear for a while making the patient believe the disease has been cured, which is not the case. […] The symptoms usually affect the nipple and then spread to the areola and then the breast. It is common that the symptoms disappear for a while and this may be tricky as the patient takes it as a sign that the disease has cured, which is not true. […] If you notice skin irritation on the breast that does not seem to heal for over a month, seek the opinion of a specialist as to whether you have Pagets disease.

• #19 Paget’s Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/breast-cancer/guide/paget-disease/

  The symptoms of Pagets disease appear on the nipple and usually the areola. Most often, they occur on one breast, but they can also occur on both breasts. These symptoms include: […] Pagets disease is sometimes misdiagnosed as skin conditions such as breast eczema and dermatitis affecting the nipple, since the symptom can appear similar. […] Complicating matters, the symptoms of Pagets disease may appear to improve at first or respond to topical treatment, which can lead some people to think the skin is healing. Eventually though, the symptoms will worsen. […] Many people with Pagets disease of the breast will go several months before theyre finally diagnosed. […] The symptoms of Pagets disease can appear similar to those of breast eczema and dermatitis affecting the nipple which is one reason why the condition can be misdiagnosed. […] If Pagets disease hasnt spread to the surrounding breast tissue, the prognosis is excellent.

• #20 What Is Paget’s Disease of the Breast | Breast Care Center Miami

  https://www.toplinemd.com/breast-care-center-of-miami/blog/what-is-pagets-disease-of-the-breast/

  A common question regarding this condition is: How quickly does Paget’s disease of the breast progress? The progression can vary greatly from person to person. In some cases, it can develop slowly over months or even years, while in others, it may progress more rapidly. Regular breast exams and consultations with healthcare providers are crucial for monitoring any changes or developments.

• #21 Paget’s Disease of Breast: Symptoms and Treatment | Doctor

  https://patient.info/doctor/pagets-disease-of-breast

  Paget’s disease of breast symptoms (presentation) […] It is usually unilateral but can occur bilaterally. […] […] It usually involves the nipple but can extend to involve other areolar skin. […] It presents as chronic eczematous change of the nipple with: […] Itching. […] Erythema. […] Scale formation. […] Erosions. […] Nipple discharge including bleeding. […] An underlying palpable breast lump (usually indicates an invasive nature). […] Prognosis […] Delay in presentation or diagnosis is common, with diagnosis made 12 months after onset in women and 8-9 months in men. Prognosis is therefore not as good as for more common forms of breast cancer. Prognosis is particularly poor for males, with a 20-30% five-year survival.

• #22 Paget’s disease of the breast | Breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/pagets-disease-breast

  Paget’s disease is a sign that there might be breast cancer in the tissues behind the nipple. […] It usually first appears as a red, scaly rash of the skin over the nipple and areola. It can be itchy, painful or cause a burning sensation. You might have some discharge or bleeding from the nipple. Or the nipple can change in appearance, going inwards when it wasn’t inverted before. […] While Paget’s disease of the breast can cause these particular symptoms, it’s worth being aware of the general symptoms of breast cancer.

• #23 Paget Disease of the Breast | Details, Diagnosis and Signs | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/paget-disease-of-the-nipple.html

  Paget disease of the breast is a rare type of breast cancer involving the skin of the nipple and the areola (the dark circle around the nipple). The skin of the nipple and areola often looks crusted, scaly, and red. There may be blood or yellow fluid coming out of the nipple. Sometimes the nipple looks flat or inverted. It also might burn or itch. Paget disease usually affects only one breast. In 80-90% of cases, its usually found along with either ductal carcinoma in situ (DCIS) or infiltrating ductal carcinoma (invasive breast cancer). […] Paget disease can be treated by removing the entire breast (mastectomy) or breast-conserving surgery (BCS) followed by whole-breast radiation therapy. If BCS is done, the entire nipple and areola area also needs to be removed. If invasive cancer is found, the lymph nodes under the arm will be checked for cancer. If no lump is felt in the breast tissue, and your biopsy results show the cancer has not spread within the breast tissue, the outlook (prognosis) is excellent. If the cancer has spread within the breast tissue (is invasive), the outlook is not as good, and the cancer will be staged and treated like any other invasive ductal carcinoma.

• #24 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  Pagets disease of the breast or nipple involves dry skin, flaking, or changes in the color or shape of the nipple. It may look like eczema or psoriasis, but it can be a sign of breast cancer. […] The symptoms of Pagets disease of the breast can resemble those of a skin condition, such as eczema or psoriasis. This sometimes delays diagnosis, increasing the risk of the condition advancing. […] Pagets disease of the breast causes skin symptoms on the breasts or nipples because of underlying breast cancer. In 80% to 90% of people with Pagets disease of the breast, the underlying cancer is either ductal carcinoma in situ (DCIS) or invasive breast cancer. […] The symptoms of Pagets disease vary depending on the stage of development. […] The most common symptoms include: itching, tingling, or burning around the nipple and areola; skin discoloration; flaking, thickening, or scaling of the skin around the nipple that does not heal over time; nipple discharge, which may be yellow or contain blood; flattened or inverted nipples; a crusted lesion with irregular edges; a mass in the nipple; ulceration, in some cases.

• #24 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  When Pagets disease is a result of more advanced or aggressive cancers, especially invasive ductal carcinoma, there is a higher mortality rate. […] The factor that plays the most significant role in determining the outcome is early diagnosis. By the time there is a large mass or the cancer has spread to lymph nodes, the disease is more advanced and has a worse prognosis. […] Pagets disease of the breast is not usually an aggressive breast cancer. However, it can spread if a person does not seek prompt treatment. […] With early diagnosis and treatment, Pagets disease of the breast is typically curable.

• #25 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast/

  Invasive breast cancer has the potential to spread from the breast to other parts of the body. […] Treatment aims to remove the area of Pagets disease from your breast and reduce the risk of it coming back or spreading to other parts of the body. […] Surgery is usually the first treatment for Pagets disease of the breast. […] If youve been diagnosed with Pagets disease alone, youre most likely to be offered surgery to remove your nipple and areola. […] You’ll usually continue to be monitored for 5 years after your hospital-based treatments (such as surgery or radiotherapy) finish. […] Most breast cancers dont come back after treatment. But sometimes it can return, so its important you know what signs and symptoms to look out for.

• #26 Paget’s Disease of the Breast | Baptist Health

  https://www.baptisthealth.com/care-services/conditions-treatments/pagets-disease-of-the-breast

  Pagets disease of the breast typically occurs in women over 50. […] Many women who are diagnosed with Pagets disease of the breast will have a lump behind the nipple and the majority of those cases are invasive breast cancer. […] Symptoms may include: Nipple itching, Nipple burning, Dry, flaking or scaling skin of the nipple or areola, Skin rash that may be raised, red, crusting, oozing (resembles weeping eczema), raw, or bleeding, Bloody or pus-like nipple discharge, Inflammation and soreness, Flat or inverted nipple, Noticeable breast lump under the skin. […] Initially, symptoms may fluctuate but worsen over time. […] The main type of treatment for Pagets disease of the nipple is surgery. […] If Pagets disease of the breast is caught in its early stages, the prognosis for a full recovery is more likely.

• #27 Inflammatory Breast Cancer Houston | Paget’s Disease of the Nipple

  https://pinkdoorimaging.com/breast-symptoms-may-result-breast-cancer-skin-changes-nipple-inflammation/

  Another rare form of breast cancer that presents as inflammation and itching of the nipple. This rare form of cancer is generally seen in older women (average age of 57 years) but has also been reported in adolescence and women in their 80s. There may be an associated discharge from the nipple, flattening of the nipple and crusting of the skin may also be seen in this condition. A breast lump may also be felt indicating an underlying tumor. The cancer cells travel along the ducts to the nipple areolar complex and cause irritation and inflammation of the skin. Women may attribute this finding of an inflamed nipple to eczema or dermatitis and delay seeking the advice of a doctor. An itchy or red nipple and surrounding areola that does not resolve with topical treatment should prompt women to seek immediate attention of a Physician.

• #28 Paget’s disease of the nipple | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/

  Pagets disease usually affects the skin of one nipple and produces eczema-like symptoms, appearing as an itchy, red rash on the nipple that can extend to the darker area of surrounding skin (the areola). […] It can also appear as a small ulcer or dry, red, flaky patches of skin similar to psoriasis. […] Other possible symptoms include: itchiness or a burning sensation alongside visible changes to the nipple, bleeding from the skin of the nipple. […] If you’re experiencing itchiness, burning or bleeding but the nipple looks normal and isn’t red, dry or scaly this is extremely unlikely to be Pagets disease but should still be checked by a doctor. […] Pagets disease of the nipple is often associated with other forms of breast cancer. […] It’s usually treated in the same way as more common types of breast cancer, either by removing the cancerous section of the breast or sometimes by removing the entire breast a procedure known as a mastectomy. […] If Pagets disease is detected and treated in its early stages, there’s a good chance of recovery.

• #29

  https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/

  Paget’s disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. […] The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated. […] Around half of all women diagnosed with Paget’s disease of the nipple have a lump behind the nipple. In 9 out of 10 cases this is an invasive breast cancer. […] Invasive cancer is where cancerous cells invade the surrounding breast tissue. Some women with Paget’s disease have invasive breast cancer but do not have a lump. […] However, most women with Paget’s disease who do not have a lump have non-invasive cancer. This is where the cancerous cells are contained in 1 or more areas of the breast and have not spread. […] If Paget’s disease is detected and treated in its early stages, there’s a good chance of a full recovery.

• #30 What Is Paget’s Disease of the Breast?

  https://www.icliniq.com/articles/womens-health/pagets-disease-of-the-breast

  Pagets disease is the rarest form of malignancy with signs like breast cancer rash, nipple eczema, etc. The condition can be cured based on the cancer stage and early detection. In the case of stage 0, that is, if the cancer is confined to nipples only and has not spread beyond the milk ducts, Paget’s disease shows an excellent prognosis. However, if the cancer starts spreading, it becomes deadly and challenging to cure. Therefore, an early screening of the disease can bring a better outcome.

• #31

  https://www.nhs.uk/conditions/pagets-disease-nipple/diagnosis/

  As Paget’s disease of the nipple is usually a sign of breast cancer, it’s very important you see your GP if you notice changes to the tissue or skin of your breast. […] Paget’s disease of the nipple can sometimes be confused with eczema, a skin condition that also causes red, itchy and dry skin. […] Paget’s disease is a form of breast cancer and the sooner it’s diagnosed, the better the outcome is likely to be. […] A skin biopsy is often used to confirm a diagnosis of Paget’s disease of the nipple. A small tissue sample will be taken from your nipple or the skin around it. The sample will be examined under a microscope and tested to see if it’s cancerous.

• #32 Paget’s Disease Of The Nipple: Symptoms And Diagnosis In Panama

  https://www.drrobertogarcia.com/en/pagets-disease-of-the-nipple-symptoms-and-diagnosis-in-panama/

  Some cases have yellowish secretions or traces of blood. The texture may become rough, accompanied by small scabs that do not heal. These changes progress gradually, unlike temporary irritations. […] 40% of initial cases are misdiagnosed as common dermatitis. Intense itching and flakes lead to improper topical treatments. However, there are key differences: here the lesions do not respond to allergy creams. […] In Panama, updated protocols allow this condition to be differentiated from other pathologies in 72 hours. The key is to seek help for any change that persists for more than two weeks.

• #33 Paget’s disease of the breast – Vejthani Hospital | JCI Accredited International Hospital in Bangkok, Thailand.

  https://www.vejthani.com/diseases-conditions/pagets-disease-of-the-breast/

  Usually, signs and symptoms of this condition are only present in one breast, starting in the nipple and potentially spreading to other parts of the breast. Skin changes may appear and disappear early on or improve with topical treatment, leading to the illusion of healing. Typically, signs and symptoms persist for several months before a diagnosis is confirmed. […] It is important to monitor any changes in your breasts. If you detect a lump or experience persistent itching or skin irritation for over a month, schedule an appointment with your doctor. Additionally, if treatment for a breast injury does not resolve the issue, schedule a follow-up appointment with your doctor.

• #34 Paget’s Disease of the Breast: Symptoms, Treatment, Survival

  https://www.verywellhealth.com/pagets-disease-of-the-breast-430628

  Paget’s disease of the breast is a rare cancer of the nipple and areola (the darkened skin around the nipple) closely associated with ductal carcinoma in situ (a cancer of milk ducts). Symptoms include flaking, cracking, discharge, and a flattening of the nipple. […] Pagets disease of the breast causes the skin on the nipple and the surrounding area to be red, sore, flaky, and scaly. Early on, these symptoms may come and go. […] Symptoms usually worsen with time and may include: Itching or a burning sensation in the nipple and/or areola, Flaking, crusty, or thickened skin on or around the nipple, Pain and sensitivity, Flattening of the nipple, Yellow or bloody discharge from the nipple, A lump in the affected area. […] If Paget’s disease of the breast is diagnosed and treated early, the prognosis (expected outcome) is excellent. Even when diagnosed at later stages, the prognosis remains largely optimistic. […] One of the reasons for the high survival rate is that the symptoms of Paget’s disease tend to be prominent and less likely to be missed. For this reason, more people will seek treatment when the disease is in an early stage.

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