Choroba pageta sutka – Zapobieganie i profilaktyka

Choroba pageta sutka
Zapobieganie i profilaktyka

Choroba Pageta sutka jest rzadkim nowotworem piersi, często współistniejącym z głębiej zlokalizowanym rakiem gruczołowym. Nie istnieją specyficzne metody zapobiegania tej jednostce, jednak profilaktyka raka piersi może pośrednio zmniejszyć ryzyko jej wystąpienia. Zalecenia obejmują regularną aktywność fizyczną (150-300 minut umiarkowanej lub 75-150 minut intensywnej tygodniowo), ograniczenie spożycia alkoholu do maksymalnie jednego drinka dziennie, utrzymanie prawidłowej masy ciała, dietę śródziemnomorską z oliwą z oliwek extra virgin i orzechami oraz ograniczenie hormonalnej terapii zastępczej, szczególnie terapii łączonej w okresie pomenopauzalnym. Karmienie piersią również wykazuje działanie ochronne. Regularne samobadanie piersi oraz mammografia, zalecana od 45 roku życia z corocznymi badaniami do 54 roku życia, umożliwiają wczesne wykrycie zmian nowotworowych, w tym choroby Pageta sutka, co istotnie poprawia rokowanie.

Choroba Pageta sutka – Profilaktyka

Choroba Pageta sutka (ang. Paget’s disease of the nipple) to rzadki rodzaj nowotworu piersi, który zazwyczaj występuje razem z rakiem piersi zlokalizowanym głębiej w tkance gruczołowej. Brak jest specyficznych metod zapobiegania samej chorobie Pageta sutka, jednak istnieją strategie zmniejszające ogólne ryzyko zachorowania na raka piersi, które mogą pośrednio wpływać na profilaktykę tej choroby.¹²³

Modyfikacja stylu życia

Wprowadzenie zmian w codziennym stylu życia może pomóc zmniejszyć ryzyko zachorowania na raka piersi. Zalecenia obejmują:⁴⁵⁶

Aktywność fizyczna – regularne ćwiczenia, najlepiej przez co najmniej 30 minut w większość dni tygodnia. Zaleca się 150-300 minut aktywności o umiarkowanej intensywności tygodniowo lub 75-150 minut intensywnych ćwiczeń tygodniowo.⁷⁸
Ograniczenie spożycia alkoholu – kobietom zaleca się nie więcej niż jeden drink dziennie. Badania wykazały, że alkohol może zwiększać ryzyko raka piersi.⁹¹⁰
Utrzymanie zdrowej wagi ciała – nadwaga i otyłość mogą zwiększać ryzyko zachorowania na raka piersi.¹¹¹²
Zdrowa dieta – dieta śródziemnomorska wzbogacona o oliwę z oliwek extra virgin i orzechy może zmniejszyć ryzyko raka piersi.¹³¹⁴
Ograniczenie hormonalnej terapii zastępczej – stosowanej w okresie pomenopauzalnym, szczególnie terapii łączonej, która może zwiększać ryzyko raka piersi.¹⁵¹⁶
Karmienie piersią – badania wykazały, że kobiety, które karmią piersią, mają statystycznie mniejsze ryzyko zachorowania na raka piersi niż te, które tego nie robią.¹⁷¹⁸

Wczesne wykrywanie – badania przesiewowe

Regularny skrining raka piersi nie zapobiega bezpośrednio chorobie Pageta sutka, ale umożliwia jej wczesne wykrycie, co znacząco poprawia rokowanie:¹⁹²⁰

Samokontrola piersi – poznanie wyglądu i struktury własnych piersi oraz regularna ich kontrola pozwala zauważyć wszelkie niepokojące zmiany.²¹²²
Regularne badania mammograficzne – Amerykańskie Towarzystwo Onkologiczne zaleca rozpoczęcie badań przesiewowych w kierunku raka piersi w wieku 45 lat i coroczne mammografie do 54 roku życia. Jednak zalecenia mogą się różnić w zależności od indywidualnych czynników ryzyka.²³
Konsultacje lekarskie – omówienie z lekarzem, kiedy rozpocząć badania przesiewowe, takie jak kliniczne badanie piersi i mammografia.²⁴²⁵

Mammografia może wykryć zmiany nowotworowe w piersi zanim utworzą one wyczuwalny guzek, co zwiększa szanse na wczesne rozpoznanie, również choroby Pageta sutka.²⁶²⁷

Strategie profilaktyczne dla osób z wysokim ryzykiem raka piersi

Dla osób o podwyższonym ryzyku zachorowania na raka piersi, np. z obciążonym wywiadem rodzinnym lub mutacjami genetycznymi, istnieją dodatkowe opcje profilaktyczne:²⁸²⁹

Poradnictwo i badania genetyczne

Jeśli podejrzewasz, że możesz mieć geny zwiększające ryzyko raka piersi (np. mutacje BRCA1 i BRCA2), warto porozmawiać z lekarzem o:³⁰³¹

Przeprowadzeniu testów genetycznych
Skorzystaniu z poradnictwa genetycznego
Częstszych badaniach kontrolnych i bardziej intensywnym monitorowaniu

Chemioprofilaktyka

Leki blokujące działanie estrogenów mogą zmniejszyć ryzyko raka piersi u osób z grupy wysokiego ryzyka. Na rynku dostępne są:³²³³³⁴

Tamoksyfen – lek z grupy selektywnych modulatorów receptora estrogenowego (SERM)
Raloksyfen – dostępny na receptę dla kobiet ze zwiększonym ryzykiem raka piersi

Leki te są dostępne na receptę dla kobiet z podwyższonym ryzykiem zachorowania na raka piersi i zostały zatwierdzone przez odpowiednie organy regulacyjne w tym wskazaniu.³⁵³⁶

Chirurgia profilaktyczna

Dla kobiet z bardzo wysokim ryzykiem raka piersi, w tym choroby Pageta sutka, dostępne są operacje profilaktyczne:³⁷³⁸³⁹

Profilaktyczna mastektomia (profilaktyczne usunięcie zdrowych piersi) – może zapewnić około 90-95% redukcji ryzyka u pacjentek z mutacjami BRCA1 i BRCA2.⁴⁰
Mastektomia z zachowaniem skóry (SSM – skin-sparing mastectomy)
Mastektomia z zachowaniem brodawki sutkowej (NSM – nipple sparing mastectomy)

Pacjentki poddawane mastektomii z zachowaniem brodawki sutkowej, które mają podwyższone ryzyko raka piersi, powinny być świadome niewielkiego, ale istniejącego ryzyka wystąpienia w przyszłości zmian nowotworowych w obrębie brodawki, w tym choroby Pageta sutka. Z tego powodu ważne jest kontynuowanie kontroli klinicznych nawet po zabiegu profilaktycznym.⁴¹⁴²

Kompleksowe podejście do profilaktyki

Nie istnieje określony sposób zapobiegania chorobie Pageta sutka, jednak stosowanie się do powyższych zaleceń może zmniejszyć ogólne ryzyko zachorowania na raka piersi. Kluczowe znaczenie ma:⁴³⁴⁴

Regularne samobadanie piersi
Regularne wizyty u specjalisty chorób piersi
Przestrzeganie zalecanego harmonogramu badań przesiewowych
Modyfikacja stylu życia i diety
W przypadku wysokiego ryzyka – rozważenie dodatkowych metod profilaktyki, w tym farmakoterapii i chirurgii profilaktycznej

Odpowiednia profilaktyka i regularne badania przesiewowe mogą przyczynić się do wczesnego wykrycia choroby Pageta sutka, co znacząco poprawia rokowanie i efektywność leczenia.⁴⁵⁴⁶

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Materiały źródłowe

#1 Paget disease (cancerous tumor of the nipple) – symptoms, causes, diagnosis and treatment at different stages
https://medconsonline.com/en/blog/paget-disease
Mammary Paget disease very rarely occurs as an isolated tumor. In most cases, when it is detected, the malignant process is found not only in the nipple and areola, but also in the breast itself. Therefore, the prognosis of the disease is closely related to the prospects of the underlying cancer treatment. These, in turn, depend on the stage at which the cancer is diagnosed and its treatment is initiated. The type of cancer associated with Paget disease also plays a key role. […] There is no specific way to prevent the disease. For the timely detection of any breast condition, one should regularly do breast self-exams and visit a breast care provider.
#2 Pagetâs Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention
https://www.everydayhealth.com/breast-cancer/guide/paget-disease/
Theres no known way to prevent Pagets disease, but you can reduce your risk for breast cancer in general by making some of the following lifestyle modifications. […] Avoid or limit your alcohol intake. Alcohol can increase the risk of breast cancer, so try to limit yourself to no more than one alcoholic drink a day. […] Maintain a healthy weight. Overweight and obesity can increase the risk of breast cancer. […] Exercise regularly. Try to get at least 150 to 300 minutes of moderately intense physical activity each week, or 75 to 150 minutes of vigorously intense physical activity per week. […] Limit postmenopausal hormone therapy. Hormone therapy to ease menopause symptoms can increase the risk of breast cancer, so talk to your doctors about nonhormonal options or limiting the dosage of hormone therapy. […] Ask about genetic testing. If you suspect you may have a gene that increases your risk of breast cancer for example, you have a strong family history of the disease talk to your doctor about doing genetic testing or genetic counseling.
#3
https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/
Paget’s disease of the nipple is usually associated with breast cancer. […] A number of things may help reduce your risk of developing breast cancer. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who do not. […] Medicines called tamoxifen and raloxifene are available on the NHS for women with an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump.
#4 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#5 Pagetâs Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention
https://www.everydayhealth.com/breast-cancer/guide/paget-disease/
Theres no known way to prevent Pagets disease, but you can reduce your risk for breast cancer in general by making some of the following lifestyle modifications. […] Avoid or limit your alcohol intake. Alcohol can increase the risk of breast cancer, so try to limit yourself to no more than one alcoholic drink a day. […] Maintain a healthy weight. Overweight and obesity can increase the risk of breast cancer. […] Exercise regularly. Try to get at least 150 to 300 minutes of moderately intense physical activity each week, or 75 to 150 minutes of vigorously intense physical activity per week. […] Limit postmenopausal hormone therapy. Hormone therapy to ease menopause symptoms can increase the risk of breast cancer, so talk to your doctors about nonhormonal options or limiting the dosage of hormone therapy. […] Ask about genetic testing. If you suspect you may have a gene that increases your risk of breast cancer for example, you have a strong family history of the disease talk to your doctor about doing genetic testing or genetic counseling.
#6 Paget’s Disease of the Breast: Causes, Symptoms, and Treatments | SELF
https://www.self.com/story/pagets-disease-of-the-breast
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. Women may choose to become familiar with their breasts by occasionally inspecting their breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. Limit the amount of alcohol you drink to no more than one drink a day, if you choose to drink. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#7 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#8 Pagetâs Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention
https://www.everydayhealth.com/breast-cancer/guide/paget-disease/
Theres no known way to prevent Pagets disease, but you can reduce your risk for breast cancer in general by making some of the following lifestyle modifications. […] Avoid or limit your alcohol intake. Alcohol can increase the risk of breast cancer, so try to limit yourself to no more than one alcoholic drink a day. […] Maintain a healthy weight. Overweight and obesity can increase the risk of breast cancer. […] Exercise regularly. Try to get at least 150 to 300 minutes of moderately intense physical activity each week, or 75 to 150 minutes of vigorously intense physical activity per week. […] Limit postmenopausal hormone therapy. Hormone therapy to ease menopause symptoms can increase the risk of breast cancer, so talk to your doctors about nonhormonal options or limiting the dosage of hormone therapy. […] Ask about genetic testing. If you suspect you may have a gene that increases your risk of breast cancer for example, you have a strong family history of the disease talk to your doctor about doing genetic testing or genetic counseling.
#9 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#10 Pagetâs Disease of the Breast: Symptoms, Diagnosis, Treatment, and Prevention
https://www.webmd.com/breast-cancer/pagets-nipple-disease
Theres no definite way to prevent cancer, but some lifestyle changes can help make it less likely. […] Keep a healthy weight. […] Get regular exercise. Moderate to high-intensity activity is best. […] Limit how much alcohol you drink. Experts recommend no more than one drink a day for women and two for men. […] Breastfeeding may also lower your risk of breast cancer. […] If you have one or more breast cancer risk factors, talk to your doctor about further steps, including: […] Testing to look for changes in your genes […] More frequent checkups or screening tests […] Medicines to block estrogen such as raloxifene and tamoxifen […] Breast removal surgery (prophylactic mastectomy)
#11 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Eating a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may reduce your risk of breast cancer. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#12 Paget’s Disease of the Breast: Causes, Symptoms, and Treatments | SELF
https://www.self.com/story/pagets-disease-of-the-breast
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Women who eat a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may have a reduced risk of breast cancer. […] Preventive medications (chemoprevention). Estrogen-blocking medications may help reduce the risk of breast cancer. […] Preventive surgery. Women with a very high risk of breast cancer may choose to have their healthy breasts surgically removed (prophylactic mastectomy). […] Discuss your personal risk factors with your doctor and ask whether you would be a candidate for treatment that may reduce that risk.
#13 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Eating a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may reduce your risk of breast cancer. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#14 Paget’s Disease of the Breast: Causes, Symptoms, and Treatments | SELF
https://www.self.com/story/pagets-disease-of-the-breast
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Women who eat a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may have a reduced risk of breast cancer. […] Preventive medications (chemoprevention). Estrogen-blocking medications may help reduce the risk of breast cancer. […] Preventive surgery. Women with a very high risk of breast cancer may choose to have their healthy breasts surgically removed (prophylactic mastectomy). […] Discuss your personal risk factors with your doctor and ask whether you would be a candidate for treatment that may reduce that risk.
#15 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#16 Pagetâs Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention
https://www.everydayhealth.com/breast-cancer/guide/paget-disease/
Theres no known way to prevent Pagets disease, but you can reduce your risk for breast cancer in general by making some of the following lifestyle modifications. […] Avoid or limit your alcohol intake. Alcohol can increase the risk of breast cancer, so try to limit yourself to no more than one alcoholic drink a day. […] Maintain a healthy weight. Overweight and obesity can increase the risk of breast cancer. […] Exercise regularly. Try to get at least 150 to 300 minutes of moderately intense physical activity each week, or 75 to 150 minutes of vigorously intense physical activity per week. […] Limit postmenopausal hormone therapy. Hormone therapy to ease menopause symptoms can increase the risk of breast cancer, so talk to your doctors about nonhormonal options or limiting the dosage of hormone therapy. […] Ask about genetic testing. If you suspect you may have a gene that increases your risk of breast cancer for example, you have a strong family history of the disease talk to your doctor about doing genetic testing or genetic counseling.
#17 Paget’s disease of the nipple | NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/
Modifying certain lifestyle factors, such as reducing alcohol intake and regular exercise, may reduce your risk of developing certain types of cancer, including breast cancer. However, these factors remain controversial. […] A number of factors can help reduce your risk of developing breast cancer, including Pagets disease of the nipple. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who dont. […] In June 2013, the National Institute for Health and Care Excellence (NICE) announced that two medications, called tamoxifen and raloxifene, would be available on the NHS for women who have an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump. The procedure uses mammograms, where X-rays are taken, to create an image of the inside of your breasts.
#18
https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/
Paget’s disease of the nipple is usually associated with breast cancer. […] A number of things may help reduce your risk of developing breast cancer. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who do not. […] Medicines called tamoxifen and raloxifene are available on the NHS for women with an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump.
#19 Paget’s Disease of the Breast: What Is It, Symptoms, Treatment | RoRoRo
https://ro.co/health-guide/pagets-disease-of-the-breast/
You cannot prevent Pagetâs disease of the breast. But proper screening for breast cancer can help catch breast cancer early and improve the outcome of the disease (Monticciolo, 2020). […] The American Cancer Society recommends women start screening for breast cancer at age 45 and get annual mammogram screenings until 54 years of age (Jin, 2015). However, itâs important to talk with your healthcare provider about your medical history and family medical history because they may recommend a different screening approach.
#20 Pagetâs Disease of the Breast: Symptoms, Treatment, Survival
https://www.verywellhealth.com/pagets-disease-of-the-breast-430628
Can You Prevent Paget’s Disease of the Breast? […] There are many risk factors that you can’t control, such as getting older, but there are some lifestyle modifications that may reduce your risk of breast cancer and Paget’s disease. […] These include: Getting regular physical activity, Avoiding or limiting alcohol, Quitting smoking, Maintaining a healthy weight. […] In addition, discuss breast cancer screenings with your healthcare provider so that if you develop breast cancer, it can be detected as early as possible. Be familiar with how your breasts normally look and feel and report any changes to a healthcare provider immediately. […] For High-Risk People […] If you have a high risk of breast cancer, such as a family history or a gene mutation that raises your risk, there are additional steps you can take to try to prevent it and/or catch it early if it does occur. These options include: Genetic counseling, More frequent screenings and self-checks to look for early signs of breast cancer, Medicines to lower breast cancer risk, Preventive (prophylactic) surgery.
#21 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#22 Paget’s Disease of the Breast: Causes, Symptoms, and Treatments | SELF
https://www.self.com/story/pagets-disease-of-the-breast
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. Women may choose to become familiar with their breasts by occasionally inspecting their breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. Limit the amount of alcohol you drink to no more than one drink a day, if you choose to drink. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#23 Paget’s Disease of the Breast: What Is It, Symptoms, Treatment | RoRoRo
https://ro.co/health-guide/pagets-disease-of-the-breast/
You cannot prevent Pagetâs disease of the breast. But proper screening for breast cancer can help catch breast cancer early and improve the outcome of the disease (Monticciolo, 2020). […] The American Cancer Society recommends women start screening for breast cancer at age 45 and get annual mammogram screenings until 54 years of age (Jin, 2015). However, itâs important to talk with your healthcare provider about your medical history and family medical history because they may recommend a different screening approach.
#24 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting your breasts during a breast self-exam for breast awareness. […] Drink alcohol in moderation, if at all. If you choose to drink alcohol, do so in moderation. […] Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer.
#25 Paget’s disease of the breast
https://johnsonmemorial.org/jmh-health/disease-conditions/con-20155351
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer. Talk with your doctor about the benefits and risks of hormone therapy. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#26 Paget’s disease of the nipple | NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/
Modifying certain lifestyle factors, such as reducing alcohol intake and regular exercise, may reduce your risk of developing certain types of cancer, including breast cancer. However, these factors remain controversial. […] A number of factors can help reduce your risk of developing breast cancer, including Pagets disease of the nipple. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who dont. […] In June 2013, the National Institute for Health and Care Excellence (NICE) announced that two medications, called tamoxifen and raloxifene, would be available on the NHS for women who have an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump. The procedure uses mammograms, where X-rays are taken, to create an image of the inside of your breasts.
#27
https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/
Paget’s disease of the nipple is usually associated with breast cancer. […] A number of things may help reduce your risk of developing breast cancer. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who do not. […] Medicines called tamoxifen and raloxifene are available on the NHS for women with an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump.
#28 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Eating a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may reduce your risk of breast cancer. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#29 Pagetâs Disease of the Breast: Symptoms, Treatment, Survival
https://www.verywellhealth.com/pagets-disease-of-the-breast-430628
Can You Prevent Paget’s Disease of the Breast? […] There are many risk factors that you can’t control, such as getting older, but there are some lifestyle modifications that may reduce your risk of breast cancer and Paget’s disease. […] These include: Getting regular physical activity, Avoiding or limiting alcohol, Quitting smoking, Maintaining a healthy weight. […] In addition, discuss breast cancer screenings with your healthcare provider so that if you develop breast cancer, it can be detected as early as possible. Be familiar with how your breasts normally look and feel and report any changes to a healthcare provider immediately. […] For High-Risk People […] If you have a high risk of breast cancer, such as a family history or a gene mutation that raises your risk, there are additional steps you can take to try to prevent it and/or catch it early if it does occur. These options include: Genetic counseling, More frequent screenings and self-checks to look for early signs of breast cancer, Medicines to lower breast cancer risk, Preventive (prophylactic) surgery.
#30 Pagetâs Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention
https://www.everydayhealth.com/breast-cancer/guide/paget-disease/
Theres no known way to prevent Pagets disease, but you can reduce your risk for breast cancer in general by making some of the following lifestyle modifications. […] Avoid or limit your alcohol intake. Alcohol can increase the risk of breast cancer, so try to limit yourself to no more than one alcoholic drink a day. […] Maintain a healthy weight. Overweight and obesity can increase the risk of breast cancer. […] Exercise regularly. Try to get at least 150 to 300 minutes of moderately intense physical activity each week, or 75 to 150 minutes of vigorously intense physical activity per week. […] Limit postmenopausal hormone therapy. Hormone therapy to ease menopause symptoms can increase the risk of breast cancer, so talk to your doctors about nonhormonal options or limiting the dosage of hormone therapy. […] Ask about genetic testing. If you suspect you may have a gene that increases your risk of breast cancer for example, you have a strong family history of the disease talk to your doctor about doing genetic testing or genetic counseling.
#31 Pagetâs Disease of the Breast: Symptoms, Diagnosis, Treatment, and Prevention
https://www.webmd.com/breast-cancer/pagets-nipple-disease
Theres no definite way to prevent cancer, but some lifestyle changes can help make it less likely. […] Keep a healthy weight. […] Get regular exercise. Moderate to high-intensity activity is best. […] Limit how much alcohol you drink. Experts recommend no more than one drink a day for women and two for men. […] Breastfeeding may also lower your risk of breast cancer. […] If you have one or more breast cancer risk factors, talk to your doctor about further steps, including: […] Testing to look for changes in your genes […] More frequent checkups or screening tests […] Medicines to block estrogen such as raloxifene and tamoxifen […] Breast removal surgery (prophylactic mastectomy)
#32 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Eating a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may reduce your risk of breast cancer. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#33 Paget’s disease of the nipple | NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/
Modifying certain lifestyle factors, such as reducing alcohol intake and regular exercise, may reduce your risk of developing certain types of cancer, including breast cancer. However, these factors remain controversial. […] A number of factors can help reduce your risk of developing breast cancer, including Pagets disease of the nipple. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who dont. […] In June 2013, the National Institute for Health and Care Excellence (NICE) announced that two medications, called tamoxifen and raloxifene, would be available on the NHS for women who have an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump. The procedure uses mammograms, where X-rays are taken, to create an image of the inside of your breasts.
#34 Paget’s disease of the breast
https://johnsonmemorial.org/jmh-health/disease-conditions/con-20155351
Making changes in your daily life may help reduce your risk of breast cancer. Try to: […] Ask your doctor about breast cancer screening. Discuss with your doctor when to begin breast cancer screening exams and tests, such as clinical breast exams and mammograms. […] Limit postmenopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer. Talk with your doctor about the benefits and risks of hormone therapy. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#35 Paget’s disease of the nipple | NHS inform
https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/
Modifying certain lifestyle factors, such as reducing alcohol intake and regular exercise, may reduce your risk of developing certain types of cancer, including breast cancer. However, these factors remain controversial. […] A number of factors can help reduce your risk of developing breast cancer, including Pagets disease of the nipple. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who dont. […] In June 2013, the National Institute for Health and Care Excellence (NICE) announced that two medications, called tamoxifen and raloxifene, would be available on the NHS for women who have an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump. The procedure uses mammograms, where X-rays are taken, to create an image of the inside of your breasts.
#36
https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/
Paget’s disease of the nipple is usually associated with breast cancer. […] A number of things may help reduce your risk of developing breast cancer. […] Exercising regularly and eating a healthy, balanced diet are known to help prevent many forms of cancer, as well as other serious health conditions, such as heart disease and diabetes. […] Studies have shown that women who breastfeed are statistically less likely to develop breast cancer than those who do not. […] Medicines called tamoxifen and raloxifene are available on the NHS for women with an increased risk of developing breast cancer. […] Breast screening can pick up breast cancer before it forms a lump.
#37 Paget’s disease of the breast – Symptoms & causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-the-breast/symptoms-causes/syc-20351079
Maintain a healthy weight. If your weight is healthy, work to maintain that weight. […] Choose a healthy diet. Eating a Mediterranean diet supplemented with extra-virgin olive oil and mixed nuts may reduce your risk of breast cancer. […] If your doctor has determined that you have an increased risk of breast cancer, you may discuss options to reduce your risk, such as: […] Preventive medications (chemoprevention). Estrogen-blocking medications reduce the risk of breast cancer if you have a high risk of the disease. […] Preventive surgery. If you have a very high risk of breast cancer, you may choose to have your healthy breasts surgically removed (prophylactic mastectomy).
#38 Pagetâs Disease of the Breast: Symptoms, Diagnosis, Treatment, and Prevention
https://www.webmd.com/breast-cancer/pagets-nipple-disease
Theres no definite way to prevent cancer, but some lifestyle changes can help make it less likely. […] Keep a healthy weight. […] Get regular exercise. Moderate to high-intensity activity is best. […] Limit how much alcohol you drink. Experts recommend no more than one drink a day for women and two for men. […] Breastfeeding may also lower your risk of breast cancer. […] If you have one or more breast cancer risk factors, talk to your doctor about further steps, including: […] Testing to look for changes in your genes […] More frequent checkups or screening tests […] Medicines to block estrogen such as raloxifene and tamoxifen […] Breast removal surgery (prophylactic mastectomy)
#39 Paget’s Disease of the Breast | Baptist Health
https://www.baptisthealth.com/care-services/conditions-treatments/pagets-disease-of-the-breast
There is no definite way to prevent cancer, but there are certain preventative measures that may reduce the risk of developing cancer or may allow you to detect it in its earlier stages. Prevention measures include: […] Breast removal surgery (prophylactic mastectomy).
#40 ClinMed International Library | Incidental Paget’s Disease of the Nipple in a Prophylactic Skin-Sparing Mastectomy for BRCA1 Mutation: Implications for Increased Use of Prophylactic Nipple Sparing Mastectomy | International Journal of Cancer and Clinica
https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-3-044.php?jid=ijccr
Prophylactic skin-sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) have become suitable options for breast cancer prevention in appropriate patients with hereditary risk of breast cancer. […] Prophylactic total mastectomy (TM) provides approximately 90% to 95%- risk reduction in patients with BRCA1 and BRCA 2 mutations. […] Increased genetic testing in unaffected women who pursue prophylactic mastectomy may lead to more detection of incidental malignancies even in the era of breast MRI screening. Patients undergoing nipple sparing mastectomy who also have increased risk of breast cancer should be aware of the chance, albeit small, of future malignancy involving the nipple. […] Nipple sparing mastectomy has become an increasingly utilized technique for appropriate breast cancer patients and those at high risk for breast cancer with low incidence of future recurrences. […] Although uncommon, the incidental pathologic finding of Paget’s disease in the nipple raises the importance of continued clinical follow up in high risk patients who increasingly undergo nipple sparing mastectomy.
#41 ClinMed International Library | Incidental Paget’s Disease of the Nipple in a Prophylactic Skin-Sparing Mastectomy for BRCA1 Mutation: Implications for Increased Use of Prophylactic Nipple Sparing Mastectomy | International Journal of Cancer and Clinica
http://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-3-044.php?jid=ijccr
Prophylactic skin-sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) have become suitable options for breast cancer prevention in appropriate patients with hereditary risk of breast cancer. Prophylactic total mastectomy (TM) provides approximately 90% to 95%- risk reduction in patients with BRCA1 and BRCA 2 mutations. […] Incidental Paget’s disease in prophylactic mastectomy specimens raises the concern for continued long term follow-up of high risk patients undergoing NSM. […] Patients undergoing nipple sparing mastectomy who also have increased risk of breast cancer should be aware of the chance, albeit small, of future malignancy involving the nipple. […] Although uncommon, the incidental pathologic finding of Paget’s disease in the nipple raises the importance of continued clinical follow up in high risk patients who increasingly undergo nipple sparing mastectomy.
#42 ClinMed International Library | Incidental Paget’s Disease of the Nipple in a Prophylactic Skin-Sparing Mastectomy for BRCA1 Mutation: Implications for Increased Use of Prophylactic Nipple Sparing Mastectomy | International Journal of Cancer and Clinica
https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-3-044.php?jid=ijccr
Prophylactic skin-sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) have become suitable options for breast cancer prevention in appropriate patients with hereditary risk of breast cancer. […] Prophylactic total mastectomy (TM) provides approximately 90% to 95%- risk reduction in patients with BRCA1 and BRCA 2 mutations. […] Increased genetic testing in unaffected women who pursue prophylactic mastectomy may lead to more detection of incidental malignancies even in the era of breast MRI screening. Patients undergoing nipple sparing mastectomy who also have increased risk of breast cancer should be aware of the chance, albeit small, of future malignancy involving the nipple. […] Nipple sparing mastectomy has become an increasingly utilized technique for appropriate breast cancer patients and those at high risk for breast cancer with low incidence of future recurrences. […] Although uncommon, the incidental pathologic finding of Paget’s disease in the nipple raises the importance of continued clinical follow up in high risk patients who increasingly undergo nipple sparing mastectomy.
#43 Paget disease (cancerous tumor of the nipple) – symptoms, causes, diagnosis and treatment at different stages
https://medconsonline.com/en/blog/paget-disease
Mammary Paget disease very rarely occurs as an isolated tumor. In most cases, when it is detected, the malignant process is found not only in the nipple and areola, but also in the breast itself. Therefore, the prognosis of the disease is closely related to the prospects of the underlying cancer treatment. These, in turn, depend on the stage at which the cancer is diagnosed and its treatment is initiated. The type of cancer associated with Paget disease also plays a key role. […] There is no specific way to prevent the disease. For the timely detection of any breast condition, one should regularly do breast self-exams and visit a breast care provider.
#44 Paget’s Disease of the Breast: What Is It, Symptoms, Treatment | RoRoRo
https://ro.co/health-guide/pagets-disease-of-the-breast/
You cannot prevent Pagetâs disease of the breast. But proper screening for breast cancer can help catch breast cancer early and improve the outcome of the disease (Monticciolo, 2020). […] The American Cancer Society recommends women start screening for breast cancer at age 45 and get annual mammogram screenings until 54 years of age (Jin, 2015). However, itâs important to talk with your healthcare provider about your medical history and family medical history because they may recommend a different screening approach.
#45 Paget disease (cancerous tumor of the nipple) – symptoms, causes, diagnosis and treatment at different stages
https://medconsonline.com/en/blog/paget-disease
Mammary Paget disease very rarely occurs as an isolated tumor. In most cases, when it is detected, the malignant process is found not only in the nipple and areola, but also in the breast itself. Therefore, the prognosis of the disease is closely related to the prospects of the underlying cancer treatment. These, in turn, depend on the stage at which the cancer is diagnosed and its treatment is initiated. The type of cancer associated with Paget disease also plays a key role. […] There is no specific way to prevent the disease. For the timely detection of any breast condition, one should regularly do breast self-exams and visit a breast care provider.
#46 Paget’s disease of the nipple | nidirect
https://www.nidirect.gov.uk/conditions/pagets-disease-nipple
Changing some lifestyle factors may reduce your risk of developing certain types of cancer, including Paget’s disease of the nipple. […] These include: reducing the amount of alcohol you drink, exercising regularly. […] Breast cancer screening is also used to help detect breast cancer early.