Materiały źródłowe

• #1 Primary amyloidosis – UF Health

  https://ufhealth.org/conditions-and-treatments/primary-amyloidosis

  There is no known prevention for primary amyloidosis.

• #2 AL Amyloidosis (Primary Amyloidosis): Symptoms, Treatment & What it Is

  https://my.clevelandclinic.org/health/diseases/15718-amyloidosis-al-amyloid-light-chain

  No, you cant prevent AL amyloidosis or other forms of amyloidosis. AL amyloidosis happens when a single plasma cell makes a clone that begins to multiply uncontrollably.

• #3 Amyloidosis Causes, Diagnosis, Symptoms, Treatment, Complications

  https://www.medicinenet.com/amyloidosis/article.htm

  Is it possible to prevent amyloidosis? […] There is no prevention for amyloidosis. However, the secondary forms of amyloidosis can be prevented by treating the underlying diseases that are associated with inflammation. Genetic counseling can be beneficial in familial amyloidosis.

• #4 AA amyloidosis: Treatment – UpToDate

  https://www.uptodate.com/contents/treatment-of-aa-secondary-amyloidosis

  AA (secondary) amyloidosis is a condition in which fragments of serum amyloid A protein (SAA) form fibrils that are deposited in extracellular tissue. This process is usually driven by inflammation, as SAA is an acute phase reactant. AA amyloidosis may complicate several chronic inflammatory conditions, including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), autoinflammatory diseases, inflammatory bowel disease (IBD), chronic infections, and certain neoplasms (table 1) [1-3]. […] Since the pathogenesis of AA amyloidosis largely depends on inflammation related to another condition, control of the underlying condition should in theory reduce the risk of developing AA amyloidosis. […] There has been a dramatic reduction in cases of AA amyloidosis after the introduction of more effective treatments for various inflammatory conditions, such as familial Mediterranean fever (FMF) or juvenile idiopathic arthritis (JIA) [4]. However, data are limited to support specific preventive strategies in patients who have conditions that increase their likelihood of developing AA amyloidosis.

• #5 Amyloidosis & Kidney Disease – NIDDK

  https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis

  Most types of amyloidosis are not preventable, but managing your kidney disease may help you delay or avoid kidney failure. […] You may be able to prevent AA amyloidosis if your chronic inflammatory condition is treated early and the inflammation is kept under control. If you have familial Mediterranean fever, your health care professional may use a medicine called colchicine to treat the inflammation and help prevent AA amyloidosis from developing.

• #6 AA amyloidosis: Treatment – UpToDate

  https://www.uptodate.com/contents/treatment-of-aa-secondary-amyloidosis

  AA (secondary) amyloidosis is a condition in which fragments of serum amyloid A protein (SAA) form fibrils that are deposited in extracellular tissue. This process is usually driven by inflammation, as SAA is an acute phase reactant. AA amyloidosis may complicate several chronic inflammatory conditions, including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), autoinflammatory diseases, inflammatory bowel disease (IBD), chronic infections, and certain neoplasms (table 1) [1-3]. […] Since the pathogenesis of AA amyloidosis largely depends on inflammation related to another condition, control of the underlying condition should in theory reduce the risk of developing AA amyloidosis. […] There has been a dramatic reduction in cases of AA amyloidosis after the introduction of more effective treatments for various inflammatory conditions, such as familial Mediterranean fever (FMF) or juvenile idiopathic arthritis (JIA) [4]. However, data are limited to support specific preventive strategies in patients who have conditions that increase their likelihood of developing AA amyloidosis.

• #7 AA amyloidosis: Treatment – UpToDate

  https://www.uptodate.com/contents/treatment-of-aa-secondary-amyloidosis

  FMF – Colchicine is commonly used for the prevention of AA amyloidosis in patients with FMF, which is the most common monogenic autoinflammatory disease worldwide and is associated with MEFV mutations; this is discussed in more detail elsewhere. FMF variants associated with AA amyloid are M694V (homozygous, heterozygous, and deletion mutant) and, to a lesser extent, (M680I not M690I).

• #8 Amyloidosis & Kidney Disease – NIDDK

  https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis

  Most types of amyloidosis are not preventable, but managing your kidney disease may help you delay or avoid kidney failure. […] You may be able to prevent AA amyloidosis if your chronic inflammatory condition is treated early and the inflammation is kept under control. If you have familial Mediterranean fever, your health care professional may use a medicine called colchicine to treat the inflammation and help prevent AA amyloidosis from developing.

• #9 Successful treatment of AA amyloidosis with tocilizumab, resulting in the disappearance of amyloid deposits: a case-based review | Egyptian Rheumatology and Rehabilitation | Full Text

  https://erar.springeropen.com/articles/10.1186/s43166-024-00281-6

  Tocilizumab treatment controls chronic inflammatory disease and improves symptoms of AA amyloidosis. […] According to the latest evidence, long-term treatment with tocilizumab may remove amyloid deposits from tissues, leading to a definitive cure for this disease. […] The fact that the clearance of the deposits is possible indicates we should aim for a definitive cure for this disease, not only to control the inflammation.

• #10 Transthyretin-Related Amyloidosis Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/335301-treatment

  There are no known primary preventive measures. Once the diagnosis has been made, medical and surgical treatments serve as secondary prevention, and supportive care for complications serve as tertiary prevention. […] Close follow-up of asymptomatic carriers of TTR gene mutations has been recommended to facilitate early recognition of ATTR onset and intervention with disease-modifying therapy. […] Ideally, patients who may be candidates for liver transplantation or possibly multi-organ transplantation, depending on heart and/or kidney involvement should be referred while early in stage I.

• #11 Transthyretin-Related Amyloidosis Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/335301-treatment

  There are no known primary preventive measures. Once the diagnosis has been made, medical and surgical treatments serve as secondary prevention, and supportive care for complications serve as tertiary prevention. […] Close follow-up of asymptomatic carriers of TTR gene mutations has been recommended to facilitate early recognition of ATTR onset and intervention with disease-modifying therapy. […] Ideally, patients who may be candidates for liver transplantation or possibly multi-organ transplantation, depending on heart and/or kidney involvement should be referred while early in stage I.

• #12 Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

  https://ctv.veeva.com/study/acoramidis-transthyretin-amyloidosis-prevention-trial-in-the-young-act-early-study-in-asymptomatic

  This study is intended to determine if treatment with acoramidis in participants with ATTRv who have not yet developed any symptoms of disease can prevent or delay the development of ATTR-CM or ATTR-PN disease. […] If adults with an inherited defective TTR gene are treated early before any of the symptoms of disease have developed, it may be possible to delay the onset or prevent the disease entirely. […] Primary purpose Prevention

• #13 Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant | Clinical Research Trial Listing

  https://www.centerwatch.com/clinical-trials/listings/NCT06563895/acoramidis-transthyretin-amyloidosis-prevention-trial-in-the-young-act-early-study-in-asymptomatic-carriers-of-a-pathogenic-ttr-variant

  This study is intended to determine if treatment with acoramidis in participants with ATTRv who have not yet developed any symptoms of disease can prevent or delay the development of ATTR-CM or ATTR-PN disease. […] If adults with an inherited defective TTR gene are treated early before any of the symptoms of disease have developed, it may be possible to delay the onset or prevent the disease entirely. […] The AG10-501 ACT-EARLY study is a randomized, multicenter, double-blind, placebo-controlled study of acoramidis for prevention of ATTR (with specific reference to either its cardiomyopathic or polyneuropathic manifestations).

• #14 American Heart Association

  https://www.healio.com/news/cardiology/20241116/crispr-geneediting-therapy-shows-promise-as-cardiac-amyloidosis-treatment-in-early-study

  In an early study, a gene-editing therapy drastically reduced levels of transthyretin, the protein that causes cardiac amyloidosis. […] These results represent the first link of evidence of in vivo CRISPR-designed gene-editing in cardiomyopathy showing that targeted inactivation of the TTR gene may reduce disease progression in ATTR cardiomyopathy. […] Taking into account the markers of disease progression represented by NT-pro BNP, troponin and 6-minute walk distance, nearly 80% patients stabilized or improved in terms of disease progression. […] The effects of nex-z on clinical outcomes are currently being evaluated in MAGNITUDE, an ongoing phase 3 randomized, placebo-controlled trial in patients with ATTR cardiomyopathy. […] Cuddy said amyloidosis was barely recognized as significant 50 years ago and in large part due to work in the past decade has progressed to having multiple effective therapies and possibly a cure in the coming decade. […] The point is to stop the progression.

• #15 Arginine: A potential prophylactic supplement for transthyretin amyloidosis – PubMed

  https://pubmed.ncbi.nlm.nih.gov/39500040/

  Transthyretin (TTR) is an amyloidogenic protein associated with TTR amyloidosis (ATTR). […] Therefore, in this study, we aimed to identify a prophylactic supplement that suppresses TTR amyloid formation. […] As arginine is a common supplement and non-toxic amino acid, it can be used as a promising prophylactic supplement to suppress amyloid fibril formation in ATTR.

• #16 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #17 Amyloidosis Causes, Diagnosis, Symptoms, Treatment, Complications

  https://www.medicinenet.com/amyloidosis/article.htm

  Is it possible to prevent amyloidosis? […] There is no prevention for amyloidosis. However, the secondary forms of amyloidosis can be prevented by treating the underlying diseases that are associated with inflammation. Genetic counseling can be beneficial in familial amyloidosis.

• #18 Alnylam Act® hATTR Amyloidosis Sponsored Testing Program – PreventionGenetics

  https://www.preventiongenetics.com/sponsoredTesting/ttr

  Alnylam Pharmaceuticals and PreventionGenetics have partnered to offer no-charge genetic testing and counseling for adults 18 years of age and older who may carry a gene variant known to be associated with hereditary ATTR (hATTR) amyloidosis. […] The Alnylam Act program was created to provide access to genetic testing and counseling to patients as a way to help people make more informed decisions about their health. […] Individuals in the US and Canada tested through the Alnylam Act program are eligible for optional pre- and post-test genetic counseling to help them understand their test results. This service is provided through GenomeMedical, a third-party genetic counseling service, and is made available by Alnylam at no charge as part of the program. […] Pre-test genetic counseling is intended to help the patient learn more about what to expect during the genetic testing process.

• #19 Alnylam Act® hATTR Amyloidosis Sponsored Testing Program – PreventionGenetics

  https://www.preventiongenetics.com/sponsoredTesting/ttr

  Alnylam Pharmaceuticals and PreventionGenetics have partnered to offer no-charge genetic testing and counseling for adults 18 years of age and older who may carry a gene variant known to be associated with hereditary ATTR (hATTR) amyloidosis. […] The Alnylam Act program was created to provide access to genetic testing and counseling to patients as a way to help people make more informed decisions about their health. […] Individuals in the US and Canada tested through the Alnylam Act program are eligible for optional pre- and post-test genetic counseling to help them understand their test results. This service is provided through GenomeMedical, a third-party genetic counseling service, and is made available by Alnylam at no charge as part of the program. […] Pre-test genetic counseling is intended to help the patient learn more about what to expect during the genetic testing process.

• #20 Cardiac Amyloidosis: Symptoms & Treatment | Mass General Brigham

  https://www.massgeneralbrigham.org/en/patient-care/services-and-specialties/heart/conditions/cardiac-amyloidosis

  Cardiac amyloidosis is generally not preventable. However, for patients with familial amyloidosis, proactive screening of family members can help identify those with the abnormal gene. There are then therapeutic interventions that may potentially prevent the onset of the disease.

• #21 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #22 Amyloidosis | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/amyloidosis

  The aims of treatment are to prevent further deposits of amyloid proteins and ease the symptoms. […] Treatment options depend on the form of amyloidosis, what organs are affected and the associated symptoms. […] A special diet tailored to your needs for example, a person with affected kidneys will benefit from a low-salt diet. […] The aims of treatment are to prevent further deposits of amyloid proteins and ease the symptoms.

• #23 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #24 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  To prevent the progression of amyloidosis and the damage it can cause, your doctor can recommend a treatment plan. The type of treatment will depend on the kind of amyloidosis you have. It will likely include medication, such as chemotherapy or corticosteroids. It could also involve a procedure, such as a transplant or surgery. Still, treatment for amyloidosis doesnt have to stop with conventional medication. […] Reducing the amount of salt in your diet can help if fluid buildup in the body causes swelling. […] Your doctor may recommend following a low salt diet to help with swelling. This can also protect your heart and kidneys from further damage. […] If eating traditional meals isnt appealing to you, you may want to talk with your doctor about meal replacement shakes or smoothies. This can help you get the nutrients your body needs to maintain energy and brain and muscle function.

• #25 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #26 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  To prevent the progression of amyloidosis and the damage it can cause, your doctor can recommend a treatment plan. The type of treatment will depend on the kind of amyloidosis you have. It will likely include medication, such as chemotherapy or corticosteroids. It could also involve a procedure, such as a transplant or surgery. Still, treatment for amyloidosis doesnt have to stop with conventional medication. […] Reducing the amount of salt in your diet can help if fluid buildup in the body causes swelling. […] Your doctor may recommend following a low salt diet to help with swelling. This can also protect your heart and kidneys from further damage. […] If eating traditional meals isnt appealing to you, you may want to talk with your doctor about meal replacement shakes or smoothies. This can help you get the nutrients your body needs to maintain energy and brain and muscle function.

• #27 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  To prevent the progression of amyloidosis and the damage it can cause, your doctor can recommend a treatment plan. The type of treatment will depend on the kind of amyloidosis you have. It will likely include medication, such as chemotherapy or corticosteroids. It could also involve a procedure, such as a transplant or surgery. Still, treatment for amyloidosis doesnt have to stop with conventional medication. […] Reducing the amount of salt in your diet can help if fluid buildup in the body causes swelling. […] Your doctor may recommend following a low salt diet to help with swelling. This can also protect your heart and kidneys from further damage. […] If eating traditional meals isnt appealing to you, you may want to talk with your doctor about meal replacement shakes or smoothies. This can help you get the nutrients your body needs to maintain energy and brain and muscle function.

• #28 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #29 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #30 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #31 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #32 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Both prevention and AA treatment usually consists of tackling the underlying inflammatory condition. This helps to lower the level of circulating inflammation and AA protein in the bloodstream, which then prevents the formation of more amyloid from its precursor and the contributions of dead cell debris. In this regard, treatment often consists of comorbid medications and therapeutics in tandem with antibiotics (if necessary), anti-inflammatories such as aspirin, and blood-thinning agents such as warfarin. […] A focus on the following aspects of health may help to improve the prevention of amyloidosis as well as enhance outcomes for those with the condition: […] Keeping Inflammation in Check. Most of the suggestions below serve to keep inflammation in check. Immune support, constant physical activity, stress management, getting enough sleep and sunlight, as well as consuming a nutritionally balanced diet (low in AGEs) all help to reduce the production of amyloid by preventing and regulating various types of inflammation. Avoiding injuries, minimizing infection risk, resting properly when unwell, and opting for adequate medical treatment are also important. Those with amyloidosis may not be able to exert themselves or consume a diet containing any animal products or refined foods.

• #33 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #34 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  To prevent the progression of amyloidosis and the damage it can cause, your doctor can recommend a treatment plan. The type of treatment will depend on the kind of amyloidosis you have. It will likely include medication, such as chemotherapy or corticosteroids. It could also involve a procedure, such as a transplant or surgery. Still, treatment for amyloidosis doesnt have to stop with conventional medication. […] Reducing the amount of salt in your diet can help if fluid buildup in the body causes swelling. […] Your doctor may recommend following a low salt diet to help with swelling. This can also protect your heart and kidneys from further damage. […] If eating traditional meals isnt appealing to you, you may want to talk with your doctor about meal replacement shakes or smoothies. This can help you get the nutrients your body needs to maintain energy and brain and muscle function.

• #35 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Fat and Cholesterol Balance. Healthy HDL is vital for keeping systemic SAA levels balanced, even during inflammatory conditions. This involves maintaining the health and functioning of the liver and, by extension, the digestive tract. The diet should include a moderate amount of good-quality fats in order to keep the HDL:LDL ratio in check and lower the burden on the liver with respect to fat metabolism. Post-prandial hyperglycemia and refined carbohydrates ought to also be minimized where possible, as these can substantially detract from fat metabolism and liver function. […] Antioxidants, Anti-inflammatories, and Anticoagulants. A diet high in nutrients often contains many antioxidant compounds capable of inhibiting inflammation, as well as those that thin the blood. This is especially true of teas, herbs, and spices such as garlic, clove, ginger, green tea, and more. Several preclinical studies have also shown that propolis and many phytochemicals (plant-based nutrients) are capable of improving lysosome protein degradation, inhibiting amyloid fibril formation, and possibly even promoting the removal of amyloid deposits in the absence of SAA excess.

• #36 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Fat and Cholesterol Balance. Healthy HDL is vital for keeping systemic SAA levels balanced, even during inflammatory conditions. This involves maintaining the health and functioning of the liver and, by extension, the digestive tract. The diet should include a moderate amount of good-quality fats in order to keep the HDL:LDL ratio in check and lower the burden on the liver with respect to fat metabolism. Post-prandial hyperglycemia and refined carbohydrates ought to also be minimized where possible, as these can substantially detract from fat metabolism and liver function. […] Antioxidants, Anti-inflammatories, and Anticoagulants. A diet high in nutrients often contains many antioxidant compounds capable of inhibiting inflammation, as well as those that thin the blood. This is especially true of teas, herbs, and spices such as garlic, clove, ginger, green tea, and more. Several preclinical studies have also shown that propolis and many phytochemicals (plant-based nutrients) are capable of improving lysosome protein degradation, inhibiting amyloid fibril formation, and possibly even promoting the removal of amyloid deposits in the absence of SAA excess.

• #37 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #38 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Fat and Cholesterol Balance. Healthy HDL is vital for keeping systemic SAA levels balanced, even during inflammatory conditions. This involves maintaining the health and functioning of the liver and, by extension, the digestive tract. The diet should include a moderate amount of good-quality fats in order to keep the HDL:LDL ratio in check and lower the burden on the liver with respect to fat metabolism. Post-prandial hyperglycemia and refined carbohydrates ought to also be minimized where possible, as these can substantially detract from fat metabolism and liver function. […] Antioxidants, Anti-inflammatories, and Anticoagulants. A diet high in nutrients often contains many antioxidant compounds capable of inhibiting inflammation, as well as those that thin the blood. This is especially true of teas, herbs, and spices such as garlic, clove, ginger, green tea, and more. Several preclinical studies have also shown that propolis and many phytochemicals (plant-based nutrients) are capable of improving lysosome protein degradation, inhibiting amyloid fibril formation, and possibly even promoting the removal of amyloid deposits in the absence of SAA excess.

• #39 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Fat and Cholesterol Balance. Healthy HDL is vital for keeping systemic SAA levels balanced, even during inflammatory conditions. This involves maintaining the health and functioning of the liver and, by extension, the digestive tract. The diet should include a moderate amount of good-quality fats in order to keep the HDL:LDL ratio in check and lower the burden on the liver with respect to fat metabolism. Post-prandial hyperglycemia and refined carbohydrates ought to also be minimized where possible, as these can substantially detract from fat metabolism and liver function. […] Antioxidants, Anti-inflammatories, and Anticoagulants. A diet high in nutrients often contains many antioxidant compounds capable of inhibiting inflammation, as well as those that thin the blood. This is especially true of teas, herbs, and spices such as garlic, clove, ginger, green tea, and more. Several preclinical studies have also shown that propolis and many phytochemicals (plant-based nutrients) are capable of improving lysosome protein degradation, inhibiting amyloid fibril formation, and possibly even promoting the removal of amyloid deposits in the absence of SAA excess.

• #40 SECONDARY (AA) AMYLOIDOSIS: SYMPTOMS, CAUSES, COMPLICATIONS, AND TREATMENT | Mya Care

  https://myacare.com/blog/secondary-aa-amyloidosis-symptoms-causes-complications-and-treatment

  Fat and Cholesterol Balance. Healthy HDL is vital for keeping systemic SAA levels balanced, even during inflammatory conditions. This involves maintaining the health and functioning of the liver and, by extension, the digestive tract. The diet should include a moderate amount of good-quality fats in order to keep the HDL:LDL ratio in check and lower the burden on the liver with respect to fat metabolism. Post-prandial hyperglycemia and refined carbohydrates ought to also be minimized where possible, as these can substantially detract from fat metabolism and liver function. […] Antioxidants, Anti-inflammatories, and Anticoagulants. A diet high in nutrients often contains many antioxidant compounds capable of inhibiting inflammation, as well as those that thin the blood. This is especially true of teas, herbs, and spices such as garlic, clove, ginger, green tea, and more. Several preclinical studies have also shown that propolis and many phytochemicals (plant-based nutrients) are capable of improving lysosome protein degradation, inhibiting amyloid fibril formation, and possibly even promoting the removal of amyloid deposits in the absence of SAA excess.

• #41 WO/2009/086539 TREATMENT AND PROPHYLAXIS OF AMYLOIDOSIS

  https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009086539

  Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. […] Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

• #42 American Heart Association

  https://www.healio.com/news/cardiology/20241116/crispr-geneediting-therapy-shows-promise-as-cardiac-amyloidosis-treatment-in-early-study

  In an early study, a gene-editing therapy drastically reduced levels of transthyretin, the protein that causes cardiac amyloidosis. […] These results represent the first link of evidence of in vivo CRISPR-designed gene-editing in cardiomyopathy showing that targeted inactivation of the TTR gene may reduce disease progression in ATTR cardiomyopathy. […] Taking into account the markers of disease progression represented by NT-pro BNP, troponin and 6-minute walk distance, nearly 80% patients stabilized or improved in terms of disease progression. […] The effects of nex-z on clinical outcomes are currently being evaluated in MAGNITUDE, an ongoing phase 3 randomized, placebo-controlled trial in patients with ATTR cardiomyopathy. […] Cuddy said amyloidosis was barely recognized as significant 50 years ago and in large part due to work in the past decade has progressed to having multiple effective therapies and possibly a cure in the coming decade. […] The point is to stop the progression.

• #43 WO/2009/086539 TREATMENT AND PROPHYLAXIS OF AMYLOIDOSIS

  https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009086539

  Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. […] Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

• #44 WO/2009/086539 TREATMENT AND PROPHYLAXIS OF AMYLOIDOSIS

  https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009086539

  Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. […] Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

• #45 American Heart Association

  https://www.healio.com/news/cardiology/20241116/crispr-geneediting-therapy-shows-promise-as-cardiac-amyloidosis-treatment-in-early-study

  In an early study, a gene-editing therapy drastically reduced levels of transthyretin, the protein that causes cardiac amyloidosis. […] These results represent the first link of evidence of in vivo CRISPR-designed gene-editing in cardiomyopathy showing that targeted inactivation of the TTR gene may reduce disease progression in ATTR cardiomyopathy. […] Taking into account the markers of disease progression represented by NT-pro BNP, troponin and 6-minute walk distance, nearly 80% patients stabilized or improved in terms of disease progression. […] The effects of nex-z on clinical outcomes are currently being evaluated in MAGNITUDE, an ongoing phase 3 randomized, placebo-controlled trial in patients with ATTR cardiomyopathy. […] Cuddy said amyloidosis was barely recognized as significant 50 years ago and in large part due to work in the past decade has progressed to having multiple effective therapies and possibly a cure in the coming decade. […] The point is to stop the progression.

• #46 Amyloidosis: Causes, Symptoms, Diagnosis & Treatment

  https://www.nanavatimaxhospital.org/blogs/understanding-amyloidosis-what-it-is-and-how-to-treat-it

  There is no known way to prevent amyloidosis, but early detection can help manage the condition. Routine medical check-ups and monitoring underlying health conditions can reduce risks.

• #47 Amyloidosis: Causes, Symptoms, Diagnosis & Treatment

  https://www.clevelandclinicabudhabi.ae/en/health-hub/health-resource/diseases-and-conditions/amyloidosis

  Amyloidosis cant be prevented, but it may be possible to control how much it affects your quality of life by understanding your risk. […] Your doctor can then monitor you and aim to diagnose and treat the condition while it is in the early stages.

• #48 Amyloidosis: Causes, Symptoms, Diagnosis & Treatment

  https://www.nanavatimaxhospital.org/blogs/understanding-amyloidosis-what-it-is-and-how-to-treat-it

  There is no known way to prevent amyloidosis, but early detection can help manage the condition. Routine medical check-ups and monitoring underlying health conditions can reduce risks.

• #49 Amyloidosis: Causes, Symptoms, Diagnosis & Treatment

  https://www.clevelandclinicabudhabi.ae/en/health-hub/health-resource/diseases-and-conditions/amyloidosis

  Amyloidosis cant be prevented, but it may be possible to control how much it affects your quality of life by understanding your risk. […] Your doctor can then monitor you and aim to diagnose and treat the condition while it is in the early stages.

• #50 Transthyretin-Related Amyloidosis Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/335301-treatment

  There are no known primary preventive measures. Once the diagnosis has been made, medical and surgical treatments serve as secondary prevention, and supportive care for complications serve as tertiary prevention. […] Close follow-up of asymptomatic carriers of TTR gene mutations has been recommended to facilitate early recognition of ATTR onset and intervention with disease-modifying therapy. […] Ideally, patients who may be candidates for liver transplantation or possibly multi-organ transplantation, depending on heart and/or kidney involvement should be referred while early in stage I.

• #51 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #52 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #53 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #54 9 Natural Therapies for Amyloidosis

  https://www.healthline.com/health/amyloidosis/natural-therapies-for-amyloidosis

  While theres no clear amyloidosis diet, dietary modifications have helped some people feel better. […] If youre experiencing bowel symptoms, its a good idea to refrain from coffee, alcohol, and spices. These can all aggravate a delicate gastrointestinal tract. […] For cardiac amyloidosis, its recommended to limit fluid intake to no more than 1.5 liters or less per day. […] Diuretics (also called water pills) are available by prescription and can help alleviate amyloidosis-related fluid retention. […] Even if you take medications or undergo other treatments for amyloidosis, complementary therapies can help. When used in conjunction with conventional medication, these therapies can make it easier to help manage your symptoms and medication side effects. […] Consider talking with your doctor about these therapies to help improve your quality of life.

• #55 Amyloidosis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/condition/amyloidosis

  Those who have hereditary amyloidosis should consider going to genetic counseling to learn about the risks of passing the condition to their children. […] Dietary choices, supplements, and herbs that reduce inflammation may help prevent worsening amyloidosis. Amyloidosis should never be treated with complementary and alternative therapies alone. Work with a knowledgeable provider and inform all of your health care providers about any medications, herbs, or supplements you are taking. […] Reducing salt intake can slow disease progression if the heart or kidneys are affected.

• #56 American Heart Association

  https://www.healio.com/news/cardiology/20241116/crispr-geneediting-therapy-shows-promise-as-cardiac-amyloidosis-treatment-in-early-study

  In an early study, a gene-editing therapy drastically reduced levels of transthyretin, the protein that causes cardiac amyloidosis. […] These results represent the first link of evidence of in vivo CRISPR-designed gene-editing in cardiomyopathy showing that targeted inactivation of the TTR gene may reduce disease progression in ATTR cardiomyopathy. […] Taking into account the markers of disease progression represented by NT-pro BNP, troponin and 6-minute walk distance, nearly 80% patients stabilized or improved in terms of disease progression. […] The effects of nex-z on clinical outcomes are currently being evaluated in MAGNITUDE, an ongoing phase 3 randomized, placebo-controlled trial in patients with ATTR cardiomyopathy. […] Cuddy said amyloidosis was barely recognized as significant 50 years ago and in large part due to work in the past decade has progressed to having multiple effective therapies and possibly a cure in the coming decade. […] The point is to stop the progression.

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