Przyklejenie łożyska
Rokowania, prognozy i postęp choroby

Placenta accreta spectrum (PAS) obejmuje patologiczne przytwierdzenie łożyska do ściany macicy, w tym placenta accreta, increta i percreta, z częstością około 1 na 500 porodów. Schorzenie to wiąże się z wysokim ryzykiem masywnych krwotoków okołoporodowych, medianą utraty krwi wynoszącą około 3000 ml oraz koniecznością transfuzji u ponad 90% pacjentek. Wczesne rozpoznanie PAS, oparte na ocenie czynników ryzyka (np. wywiad zrostów wewnątrzmacicznych, tylne położenie łożyska, łożysko przodujące) oraz ultrasonograficznym systemie punktowym o dokładności 83,9-92%, umożliwia planowanie porodu w ośrodkach o wysokim stopniu referencyjności, co znacząco poprawia rokowanie i zmniejsza śmiertelność matek. Diagnostyka przedporodowa pozwala na optymalizację przygotowania zespołu i pacjentki, w tym adekwatne przygotowanie do transfuzji krwi oraz planową histerektomię podczas cięcia cesarskiego, która pozostaje standardem leczenia w ciężkich przypadkach PAS.

Przyklejenie łożyska – wprowadzenie do oceny prognostycznej

Przyklejenie łożyska (placenta accreta spectrum, PAS) to spektrum patologicznego przytwierdzenia łożyska do ściany macicy, obejmujące placenta accreta, placenta increta oraz placenta percreta. Jest to poważne powikłanie ciąży, którego częstość występowania szacuje się obecnie na 1 na 500 porodów. Związane jest z istotnym wzrostem zachorowalności i śmiertelności matek, głównie z powodu ciężkich, zagrażających życiu krwotoków, które często wymagają transfuzji krwi.123

Wczesne rozpoznanie przyklejenia łożyska ma kluczowe znaczenie dla odpowiedniego planowania postępowania i optymalizacji wyników leczenia. Umożliwia przygotowanie zarówno pacjentki, jak i zespołu medycznego do przeprowadzenia najbardziej odpowiedniego postępowania z minimalnymi powikłaniami. Diagnostyka przedporodowa pozwala na poród w ośrodku o III lub IV stopniu referencyjności opieki położniczej przed rozpoczęciem czynności porodowej lub wystąpieniem krwawienia, co znacząco poprawia rokowanie.456

Czynniki ryzyka niewykrycia przyklejenia łożyska

Badania wskazują, że około 35% przypadków przyklejenia łożyska nie jest rozpoznawanych przed porodem, co wiąże się z gorszymi wynikami leczenia w porównaniu do przypadków wcześniej zdiagnozowanych. Czynniki związane z niewykryciem przyklejenia łożyska przed porodem obejmują:7

8

Zwiększenie świadomości tych czynników ryzyka może ułatwić wczesne rozpoznanie PAS i poprawić wyniki leczenia. Należy podkreślić, że w prawie jednej trzeciej cięć cesarskich z histerektomią z powodu przyklejenia łożyska, diagnoza była stawiana śródoperacyjnie, co podkreśla potrzebę czujności podczas operacji, ponieważ konieczność histerektomii może nie być przewidziana przed operacją.9

Metody przewidywania przebiegu przyklejenia łożyska

Ultrasonograficzny system punktowy

Opracowano ultrasonograficzny system punktowy, który może być skutecznym narzędziem diagnostycznym do oceny typów przyklejenia łożyska oraz przewidywania związanego z nim ryzyka krwawienia i konieczności wykonania histerektomii. Dokładność tego systemu w przewidywaniu patologicznych typów przyklejenia łożyska wynosi od 83,9% do 92%, co wskazuje na stosunkowo wysoką precyzję.1011

Ryzyko krwawienia podczas operacji i konieczności histerektomii jest szczególnie wysokie w przypadkach placenta increta/percreta. System punktowy pozwala na uniknięcie niedostatecznego lub nadmiernego przygotowania krwi do transfuzji, zmniejszając potencjalną zachorowalność i śmiertelność matek i dzieci.1213

Inne metody predykcyjne

Przyklejenie łożyska można przewidywać wcześnie za pomocą różnych modalności:14

  • Kliniczne czynniki ryzyka – ocena historii pacjentki i obecnych czynników ryzyka
  • Badania obrazowe we wczesnej ciąży – głównie ultrasonografia
  • Biomarkery – choć są one nadal w fazie badań, a ich pomiary mogą się różnić w zależności od techniki oszacowania i wieku ciążowego

15

Markery ultrasonograficzne są uznawane za bardziej dokładne, łatwe do śledzenia i wykazują dodatnią korelację z wynikami chirurgicznymi PAS, takimi jak utrata krwi i okołoporodowa histerektomia. Należy jednak zachować ostrożność przy stosowaniu systemów punktowych, ponieważ żaden z nich nie wykazuje absolutnej dokładności w predykcji zaburzeń PAS.1617

Rokowanie i wyniki leczenia

Przeżywalność i powikłania

Rokowanie jest ogólnie dobre, gdy przyklejenie łożyska zostanie zdiagnozowane w trakcie ciąży. Niemniej jednak występują powikłania związane z przedwczesnym porodem i możliwą histerektomią. Jeśli położnik usunie macicę, pacjentka traci możliwość zajścia w ciążę w przyszłości. Stan ten może również prowadzić do masywnej utraty krwi, uszkodzenia jelit lub pęcherza moczowego, a nawet śmierci.18

Badanie opublikowane niedawno, oparte na porodach z przyklejeniem łożyska w latach 1998-2011, wykazało, że chociaż przyklejenie łożyska wiązało się z nawet 19-krotnym wzrostem niekorzystnych wyników (w tym histerektomia, transfuzja i przedłużony pobyt w szpitalu), liczba zgonów matek w badanej grupie była bardzo niska.19

Utrata krwi i transfuzje

Mediana utraty krwi podczas porodu u kobiet z rozpoznanym przyklejeniem łożyska jest szacowana na 3000 ml. Ponadto ponad 90% wszystkich kobiet z PAS otrzymuje transfuzję koncentratu krwinek czerwonych podczas porodu.20

Analiza 17 kobiet poddanych dwuetapowemu podejściu do leczenia PAS ujawniła, że zarówno po procedurze pierwotnej (76,5%), jak i wtórnej (93,8%), wskaźnik anemii poporodowej był wysoki. Łącznie 62,7% kobiet otrzymało transfuzję koncentratu krwinek czerwonych podczas procedury wtórnej. Postępowanie w anemii i wdrożenie strategii oszczędzania krwi ma kluczowe znaczenie u kobiet z rozpoznanym PAS poddawanych embolizacji tętnic macicznych (UAE).21

Wpływ miejsca leczenia na rokowanie

Literatura dotycząca przyklejenia łożyska wskazuje, że lepsze wyniki osiąga się w ośrodkach doskonałości specjalizujących się w leczeniu przyklejenia łożyska lub w placówkach posiadających doświadczenie i wiedzę specjalistyczną w leczeniu tego schorzenia. Poród w wysoko wyspecjalizowanych ośrodkach położniczych, które posiadają skoordynowany zespół opieki i możliwość pozyskiwania dodatkowej wiedzy specjalistycznej i zasobów w przypadkach ciężkiego krwotoku, wydaje się poprawiać wyniki.2223

Opcje terapeutyczne a rokowanie

Planowa histerektomia

Planowa histerektomia podczas cięcia cesarskiego jest standardem opieki w przypadku przyklejenia łożyska. Należy zaznaczyć, że kobiety z przyklejeniem łożyska poddawane histerektomii zwykle zachowują jajniki i nie wchodzą w menopauzę w związku z histerektomią z powodu przyklejenia łożyska.2425

Leczenie zachowawcze

Leczenie zachowawcze lub wyczekujące powinno być rozważane tylko w starannie wyselekcjonowanych przypadkach przyklejenia łożyska, po szczegółowym omówieniu ryzyka, niepewnych korzyści i skuteczności, i powinno być traktowane jako postępowanie eksperymentalne.2627

Embolizacja tętnic macicznych

Embolizacja tętnic macicznych (UAE) jest alternatywą dla cesarskiego cięcia z histerektomią, pozwalającą na zachowanie macicy i poprawę krwotoku poporodowego, rekomendowaną przez kilka krajowych i międzynarodowych wytycznych. Analiza pokazuje, że podczas cesarskiego cięcia i późniejszej UAE stosowanie znieczulenia regionalnego (znieczulenie podpajęczynówkowe lub zewnątrzoponowe) jest bezpieczne, choć wskaźnik anemii poporodowej pozostaje wysoki.2829

Wartości predykcyjne we wczesnej diagnostyce

Wczesne przewidywanie przyklejenia łożyska niesie za sobą wiele korzyści, w tym:30

  • Zmniejszenie powikłań okołoporodowych
  • Pomoc w podejmowaniu decyzji i postępowaniu okołoporodowym
  • Przewidywanie stopnia ciężkości schorzenia
  • Przewidywanie utraty krwi podczas operacji
  • Przewidywanie zachorowalności i śmiertelności matek

31

Model systemu punktacji przyklejenia łożyska może być wykorzystany do oceny typu przyklejenia przed operacją, przewidywania ryzyka krwawienia śródoperacyjnego i ma pewne znaczenie w zmniejszeniu odsetka śmiertelnych krwotoków poporodowych, odsetka histerektomii u młodych kobiet oraz śmiertelności matek.3233

Znaczenie badań nad przyczepieniem łożyska

Trwają badania mające na celu wyjaśnienie czynników prognostycznych tej choroby i znalezienie indywidualnych opcji leczenia w celu poprawy rokowania pacjentek z tym typem schorzenia. Przyklejenie łożyska bez uprzedniego cięcia cesarskiego jest szczególnym obszarem zainteresowania badawczego, z próbami określenia czynników ryzyka i rokowania oraz stworzenia modelu predykcyjnego.34

Kluczowe znaczenie ma zwiększenie świadomości czynników ryzyka niewykrycia przyklejenia łożyska, takich jak wywiad zrostów wewnątrzmacicznych, klinicznie potwierdzone PAS w przeszłości, tylne położenie łożyska i łożysko przodujące w wywiadzie. Może to ułatwić wczesne rozpoznanie PAS i poprawić wyniki leczenia matek.35

Podsumowując, diagnoza przedporodowa jest kluczowa, ale równie ważna jest czujność śródoperacyjna, ponieważ konieczność histerektomii może nie być przewidziana przedoperacyjnie. Planowanie porodu w ośrodkach o wysokim stopniu specjalizacji, posiadających doświadczenie i wiedzę specjalistyczną w leczeniu przyklejenia łożyska, może znacząco poprawić wyniki leczenia.3637

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  1. 10.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    Placenta accreta spectrum, formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, placenta percreta, and placenta accreta. Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion. […] Antenatal diagnosis of placenta accreta spectrum is highly desirable because outcomes are optimized when delivery occurs at a level III or IV maternal care facility before the onset of labor or bleeding and with avoidance of placental disruption. […] Delivery in highly experienced maternity centers that have this type of coordinated care team and the ability to garner additional expertise and resources in cases of severe hemorrhage appears to improve outcomes.
  • #2 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The placenta accreta spectrum (PAS) is defined as a morbidly adherent placenta and includes placenta increta, accreta, and percreta. In recent years, the prevalence of PAS has increased and is currently estimated to be 1 out of 500 births. Despite advances in prenatal ultrasound and diagnosis and referral to experienced surgical centers, abnormal placentation remains one of the main causes for postpartum hemorrhage (PPH), increased maternal morbidity and mortality. Median blood loss during delivery in women diagnosed with PAS is estimated to be 3000 mL. In addition, >90.0% of all women with PAS receive red blood cell (RBC) transfusion during childbirth. Planned caesarean hysterectomy (HE) at the time of the delivery is the standard of care. Uterine artery embolization (UAE) is an alternative to caesarean HE, allowing preservation of the uterus and improvement of PPH, recommended by several national and international guidelines.
  • #3 National Accreta Foundation — What Do Accreta Patients Need to Know? | Placenta Accreta Patient FAQ | National Accreta Foundation
    https://www.preventaccreta.org/faq
    Placenta accreta spectrum is becoming increasingly common and is associated with significant morbidity and mortality. […] A recently published study based on accreta deliveries between 1998-2011 found that while accreta was associated with as much as a 19-fold increase in adverse outcomes (including hysterectomy, transfusion and prolonged hospital stay), there were very few maternal deaths in their sample. […] It is important to note that in general, accreta moms keep their ovaries and do not go into menopause from an accreta related hysterectomy. […] The ACOG SMFM Accreta Care Consensus states: Conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational. […] Accreta literature has previously indicated that better outcomes are achieved at a placenta accreta center of excellence, or at facilities with experience and expertise in treating accreta.
  • #4 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #5 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    Placenta accreta spectrum, formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, placenta percreta, and placenta accreta. Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion. […] Antenatal diagnosis of placenta accreta spectrum is highly desirable because outcomes are optimized when delivery occurs at a level III or IV maternal care facility before the onset of labor or bleeding and with avoidance of placental disruption. […] Delivery in highly experienced maternity centers that have this type of coordinated care team and the ability to garner additional expertise and resources in cases of severe hemorrhage appears to improve outcomes.
  • #6 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    The antenatal diagnosis of placenta accreta spectrum is critical because it provides an opportunity to optimize management and outcomes. […] Taking these limited published data together, and the accepted approach of hysterectomy to treat placenta accreta spectrum, conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational.
  • #7 Incidence, risk factors and maternal outcomes of unsuspected placenta accreta spectrum disorders: a retrospective cohort study | BMC Pregnancy and Childbirth | Full Text
    https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-024-06254-z
    Our findings indicate that 35% of patients with PAS were unsuspected prior to delivery. […] Factors associated with PAS being unsuspected prior to delivery include a history of intrauterine adhesions, a history of clinically confirmed PAS, a posterior placenta, and a history of placenta previa. […] In conclusion, our data revealed that approximately one-third of PAS cases were not suspected during antenatal screening, and these unsuspected cases exhibited poorer outcomes compared to the suspected cases. Risk factors for lack of suspicion include a history of intrauterine adhesions, clinically confirmed PAS, posterior placenta, and placenta previa. Increasing awareness of these risk factors could facilitate early diagnosis of PAS and enhance maternal outcomes.
  • #8 Incidence, risk factors and maternal outcomes of unsuspected placenta accreta spectrum disorders: a retrospective cohort study | BMC Pregnancy and Childbirth | Full Text
    https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-024-06254-z
    Our findings indicate that 35% of patients with PAS were unsuspected prior to delivery. […] Factors associated with PAS being unsuspected prior to delivery include a history of intrauterine adhesions, a history of clinically confirmed PAS, a posterior placenta, and a history of placenta previa. […] In conclusion, our data revealed that approximately one-third of PAS cases were not suspected during antenatal screening, and these unsuspected cases exhibited poorer outcomes compared to the suspected cases. Risk factors for lack of suspicion include a history of intrauterine adhesions, clinically confirmed PAS, posterior placenta, and placenta previa. Increasing awareness of these risk factors could facilitate early diagnosis of PAS and enhance maternal outcomes.
  • #9 Clinical Diagnosis of Placenta Accreta and Clinicopathological Outcomes
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7653210/
    Most patients undergoing cesarean hysterectomy for placenta accreta do have this diagnosis confirmed on pathology. […] However, since diagnosis of placenta accreta was made intraoperatively in nearly a third of cesarean hysterectomies, intraoperative vigilance is required as the need for cesarean hysterectomy may not be anticipated preoperatively. […] In conclusion, in our cohort, diagnosis of placenta accreta was first made intraoperatively in nearly a third of cesarean hysterectomies. While most patients undergoing cesarean hysterectomy for clinically diagnosed placenta accreta had the diagnosis confirmed on pathologic examination, there was a 4% false positive rate. […] These findings re-enforce the need for vigilance intraoperatively as the need for cesarean hysterectomy may not be anticipated preoperatively.
  • #10 An ultrasonic scoring system to predict the prognosis of placenta accreta
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6392640/
    To discuss the value of self-made ultrasonic scoring system in predicting the different types of placenta accreta, and for predicting its associated risk of bleeding and hysterectomy. […] These results suggested that self-made ultrasonic scoring system remained an effective diagnostic tool for assessing the types of placenta accreta, and predicted the associated bleeding risk, indicating the possibility of hysterectomy. […] The study indicated that the accuracy of the scoring system for predicting the pathologic types of placenta accreta as 83.9% to 92%, demonstrating a relatively high accuracy. […] The above-mentioned data showed that we can rely on the scoring system for predicting the type of accreta and the degree of risk. […] The model of placenta accreta scoring system can be used to evaluate the type of accreta before operation, predict the risk of intraoperative bleeding, and has a certain significance in the reduction rate of fatal postpartum hemorrhage, hysterectomy rate of young women, and maternal mortality.
  • #11
    https://journals.lww.com/md-journal/fulltext/2018/08310/an_ultrasonic_scoring_system_to_predict_the.71.aspx
    The study indicated that the accuracy of the scoring system for predicting the pathologic types of placenta accreta as 83.9% to 92%, demonstrating a relatively high accuracy. […] The above-mentioned data showed that we can rely on the scoring system for predicting the type of accreta and the degree of risk. […] This in turn avoided insufficient or excessive waste of blood preparation, reducing the potential maternal and children morbidity and mortality. […] The model of placenta accreta scoring system can be used to evaluate the type of accreta before operation, predict the risk of intraoperative bleeding, and has a certain significance in the reduction rate of fatal postpartum hemorrhage, hysterectomy rate of young women, and maternal mortality.
  • #12
    https://journals.lww.com/md-journal/fulltext/2018/08310/an_ultrasonic_scoring_system_to_predict_the.71.aspx
    To discuss the value of self-made ultrasonic scoring system in predicting the different types of placenta accreta, and for predicting its associated risk of bleeding and hysterectomy. […] These results suggested that self-made ultrasonic scoring system remained an effective diagnostic tool for assessing the types of placenta accreta, and predicted the associated bleeding risk, indicating the possibility of hysterectomy. […] The main risks included are fatal postpartum hemorrhage and high hysterectomy rates in women of reproductive age. […] The risk of bleeding during operation and hysterectomy was high for increta/percreta. […] However, the existing ultrasound technology can only diagnose placenta accreta, but due to its low sensitivity it is far from the needs of clinicians. […] Hence, a model that can predict the prognosis of placenta accreta by ultrasound examination, and to solve the above clinical problems is required.
  • #13
    https://journals.lww.com/md-journal/fulltext/2018/08310/an_ultrasonic_scoring_system_to_predict_the.71.aspx
    The study indicated that the accuracy of the scoring system for predicting the pathologic types of placenta accreta as 83.9% to 92%, demonstrating a relatively high accuracy. […] The above-mentioned data showed that we can rely on the scoring system for predicting the type of accreta and the degree of risk. […] This in turn avoided insufficient or excessive waste of blood preparation, reducing the potential maternal and children morbidity and mortality. […] The model of placenta accreta scoring system can be used to evaluate the type of accreta before operation, predict the risk of intraoperative bleeding, and has a certain significance in the reduction rate of fatal postpartum hemorrhage, hysterectomy rate of young women, and maternal mortality.
  • #14 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #15 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #16 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #17 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    We put a caution note on the use of scoring systems, as more than ten scores are herein discussed, and none of them was superior to the others. Furthermore, none of the scores showed absolute accuracy in prediction of PAS disorders. […] Biomarkers measurements vary according to technique of estimation and gestational age. Sometimes, there were no differences and sometimes there was some overlap between cases and controls, and most studies were retrospective. Biomarkers are still investigational, and further assessment of these biomarkers in predicting PAS disorders should be kept for research purposes only.
  • #18 Placenta Accreta: Types, Risks, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/17846-placenta-accreta
    Placenta accreta is a pregnancy complication that occurs when the placenta embeds too deep in the uterine wall. […] The outlook is generally good when pregnancy care providers diagnose placenta accreta during pregnancy. However, there will be complications associated with preterm labor and a possible hysterectomy. If your obstetrician removes your uterus, you’ll lose the ability to become pregnant again. This condition can also lead to massive blood loss, injury to the bowel or bladder and even death. […] The survival rate of placenta accreta is generally good. In most cases, this means you’ll have a hysterectomy to prevent postpartum hemorrhaging or other severe complications.
  • #19 National Accreta Foundation — What Do Accreta Patients Need to Know? | Placenta Accreta Patient FAQ | National Accreta Foundation
    https://www.preventaccreta.org/faq
    Placenta accreta spectrum is becoming increasingly common and is associated with significant morbidity and mortality. […] A recently published study based on accreta deliveries between 1998-2011 found that while accreta was associated with as much as a 19-fold increase in adverse outcomes (including hysterectomy, transfusion and prolonged hospital stay), there were very few maternal deaths in their sample. […] It is important to note that in general, accreta moms keep their ovaries and do not go into menopause from an accreta related hysterectomy. […] The ACOG SMFM Accreta Care Consensus states: Conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational. […] Accreta literature has previously indicated that better outcomes are achieved at a placenta accreta center of excellence, or at facilities with experience and expertise in treating accreta.
  • #20 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The placenta accreta spectrum (PAS) is defined as a morbidly adherent placenta and includes placenta increta, accreta, and percreta. In recent years, the prevalence of PAS has increased and is currently estimated to be 1 out of 500 births. Despite advances in prenatal ultrasound and diagnosis and referral to experienced surgical centers, abnormal placentation remains one of the main causes for postpartum hemorrhage (PPH), increased maternal morbidity and mortality. Median blood loss during delivery in women diagnosed with PAS is estimated to be 3000 mL. In addition, >90.0% of all women with PAS receive red blood cell (RBC) transfusion during childbirth. Planned caesarean hysterectomy (HE) at the time of the delivery is the standard of care. Uterine artery embolization (UAE) is an alternative to caesarean HE, allowing preservation of the uterus and improvement of PPH, recommended by several national and international guidelines.
  • #21 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The analysis of 17 women undergoing a two-step approach for treatment of PAS revealed that for caesarean delivery and subsequent UAE, the use of regional anesthesia (spinal or epidural anesthesia) is safe. After primary (76.5%) and secondary procedure (93.8%), postpartum anemia rate was high. In total, 62.7% of women received RBC transfusion during secondary procedure. Anemia management and the implementation of blood conservation strategies are crucial in women diagnosed with PAS undergoing UAE.
  • #22 National Accreta Foundation — What Do Accreta Patients Need to Know? | Placenta Accreta Patient FAQ | National Accreta Foundation
    https://www.preventaccreta.org/faq
    Placenta accreta spectrum is becoming increasingly common and is associated with significant morbidity and mortality. […] A recently published study based on accreta deliveries between 1998-2011 found that while accreta was associated with as much as a 19-fold increase in adverse outcomes (including hysterectomy, transfusion and prolonged hospital stay), there were very few maternal deaths in their sample. […] It is important to note that in general, accreta moms keep their ovaries and do not go into menopause from an accreta related hysterectomy. […] The ACOG SMFM Accreta Care Consensus states: Conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational. […] Accreta literature has previously indicated that better outcomes are achieved at a placenta accreta center of excellence, or at facilities with experience and expertise in treating accreta.
  • #23 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    Placenta accreta spectrum, formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, placenta percreta, and placenta accreta. Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion. […] Antenatal diagnosis of placenta accreta spectrum is highly desirable because outcomes are optimized when delivery occurs at a level III or IV maternal care facility before the onset of labor or bleeding and with avoidance of placental disruption. […] Delivery in highly experienced maternity centers that have this type of coordinated care team and the ability to garner additional expertise and resources in cases of severe hemorrhage appears to improve outcomes.
  • #24 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The placenta accreta spectrum (PAS) is defined as a morbidly adherent placenta and includes placenta increta, accreta, and percreta. In recent years, the prevalence of PAS has increased and is currently estimated to be 1 out of 500 births. Despite advances in prenatal ultrasound and diagnosis and referral to experienced surgical centers, abnormal placentation remains one of the main causes for postpartum hemorrhage (PPH), increased maternal morbidity and mortality. Median blood loss during delivery in women diagnosed with PAS is estimated to be 3000 mL. In addition, >90.0% of all women with PAS receive red blood cell (RBC) transfusion during childbirth. Planned caesarean hysterectomy (HE) at the time of the delivery is the standard of care. Uterine artery embolization (UAE) is an alternative to caesarean HE, allowing preservation of the uterus and improvement of PPH, recommended by several national and international guidelines.
  • #25 National Accreta Foundation — What Do Accreta Patients Need to Know? | Placenta Accreta Patient FAQ | National Accreta Foundation
    https://www.preventaccreta.org/faq
    Placenta accreta spectrum is becoming increasingly common and is associated with significant morbidity and mortality. […] A recently published study based on accreta deliveries between 1998-2011 found that while accreta was associated with as much as a 19-fold increase in adverse outcomes (including hysterectomy, transfusion and prolonged hospital stay), there were very few maternal deaths in their sample. […] It is important to note that in general, accreta moms keep their ovaries and do not go into menopause from an accreta related hysterectomy. […] The ACOG SMFM Accreta Care Consensus states: Conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational. […] Accreta literature has previously indicated that better outcomes are achieved at a placenta accreta center of excellence, or at facilities with experience and expertise in treating accreta.
  • #26 National Accreta Foundation — What Do Accreta Patients Need to Know? | Placenta Accreta Patient FAQ | National Accreta Foundation
    https://www.preventaccreta.org/faq
    Placenta accreta spectrum is becoming increasingly common and is associated with significant morbidity and mortality. […] A recently published study based on accreta deliveries between 1998-2011 found that while accreta was associated with as much as a 19-fold increase in adverse outcomes (including hysterectomy, transfusion and prolonged hospital stay), there were very few maternal deaths in their sample. […] It is important to note that in general, accreta moms keep their ovaries and do not go into menopause from an accreta related hysterectomy. […] The ACOG SMFM Accreta Care Consensus states: Conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational. […] Accreta literature has previously indicated that better outcomes are achieved at a placenta accreta center of excellence, or at facilities with experience and expertise in treating accreta.
  • #27 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    The antenatal diagnosis of placenta accreta spectrum is critical because it provides an opportunity to optimize management and outcomes. […] Taking these limited published data together, and the accepted approach of hysterectomy to treat placenta accreta spectrum, conservative management or expectant management should be considered only for carefully selected cases of placenta accreta spectrum after detailed counseling about the risks, uncertain benefits, and efficacy and should be considered investigational.
  • #28 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The placenta accreta spectrum (PAS) is defined as a morbidly adherent placenta and includes placenta increta, accreta, and percreta. In recent years, the prevalence of PAS has increased and is currently estimated to be 1 out of 500 births. Despite advances in prenatal ultrasound and diagnosis and referral to experienced surgical centers, abnormal placentation remains one of the main causes for postpartum hemorrhage (PPH), increased maternal morbidity and mortality. Median blood loss during delivery in women diagnosed with PAS is estimated to be 3000 mL. In addition, >90.0% of all women with PAS receive red blood cell (RBC) transfusion during childbirth. Planned caesarean hysterectomy (HE) at the time of the delivery is the standard of care. Uterine artery embolization (UAE) is an alternative to caesarean HE, allowing preservation of the uterus and improvement of PPH, recommended by several national and international guidelines.
  • #29 Management and Outcome of Women with Placenta Accreta Spectrum and Treatment with Uterine Artery Embolization
    https://www.mdpi.com/2077-0383/13/4/1062
    The analysis of 17 women undergoing a two-step approach for treatment of PAS revealed that for caesarean delivery and subsequent UAE, the use of regional anesthesia (spinal or epidural anesthesia) is safe. After primary (76.5%) and secondary procedure (93.8%), postpartum anemia rate was high. In total, 62.7% of women received RBC transfusion during secondary procedure. Anemia management and the implementation of blood conservation strategies are crucial in women diagnosed with PAS undergoing UAE.
  • #30 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #31 Early Prediction of Placenta Accreta Spectrum by Different Modalities: An Evidenced-based Analysis
    https://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101027/htm
    Objective: Early prediction of placenta accreta is crucial for proper decision making, proper preoperative preparation and proper planning for the best management. […] Prediction of PAS has a lot of benefits, including reduction of peripartum complication, help decision-making and peripartum management, predict degree of severity, predict operative blood loss, and predict maternal morbidity and mortality. […] Early prediction of PAS allows good preparation of both patient and obstetrician to conduct the best management with minimal complications. PAS could be predicted early by either clinical risk factor, imaging in early pregnancy or by biomarkers. […] From this evidence-based analysis, we conclude that PAS disorders could be predicted by different modalities. Ultrasound markers are more accurate, easy to trace, and had positive correlation to PAS surgical outcomes, such as blood loss and peripartum hysterectomy.
  • #32 An ultrasonic scoring system to predict the prognosis of placenta accreta
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6392640/
    To discuss the value of self-made ultrasonic scoring system in predicting the different types of placenta accreta, and for predicting its associated risk of bleeding and hysterectomy. […] These results suggested that self-made ultrasonic scoring system remained an effective diagnostic tool for assessing the types of placenta accreta, and predicted the associated bleeding risk, indicating the possibility of hysterectomy. […] The study indicated that the accuracy of the scoring system for predicting the pathologic types of placenta accreta as 83.9% to 92%, demonstrating a relatively high accuracy. […] The above-mentioned data showed that we can rely on the scoring system for predicting the type of accreta and the degree of risk. […] The model of placenta accreta scoring system can be used to evaluate the type of accreta before operation, predict the risk of intraoperative bleeding, and has a certain significance in the reduction rate of fatal postpartum hemorrhage, hysterectomy rate of young women, and maternal mortality.
  • #33
    https://journals.lww.com/md-journal/fulltext/2018/08310/an_ultrasonic_scoring_system_to_predict_the.71.aspx
    The study indicated that the accuracy of the scoring system for predicting the pathologic types of placenta accreta as 83.9% to 92%, demonstrating a relatively high accuracy. […] The above-mentioned data showed that we can rely on the scoring system for predicting the type of accreta and the degree of risk. […] This in turn avoided insufficient or excessive waste of blood preparation, reducing the potential maternal and children morbidity and mortality. […] The model of placenta accreta scoring system can be used to evaluate the type of accreta before operation, predict the risk of intraoperative bleeding, and has a certain significance in the reduction rate of fatal postpartum hemorrhage, hysterectomy rate of young women, and maternal mortality.
  • #34 Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section | Clinical Research Trial Listing
    https://www.centerwatch.com/clinical-trials/listings/NCT06383923/risk-factors-prognosis-and-prediction-models-for-placenta-accreta-without-prior-cesarean-section
    Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease; […] The placenta accreta spectrum (PAS) is defined as abnormal placental trophoblast adherence with a wide range of myometrial invasion. It is a serious pregnancy complication that can lead to severe postpartum hemorrhage, which may necessitate hysterectomy, and could ultimately lead to maternal death. […] This study aims to explore the risk factors and prognosis of PAS without a history of cesarean section and try to establish the prediction model.
  • #35 Incidence, risk factors and maternal outcomes of unsuspected placenta accreta spectrum disorders: a retrospective cohort study | BMC Pregnancy and Childbirth | Full Text
    https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-024-06254-z
    Our findings indicate that 35% of patients with PAS were unsuspected prior to delivery. […] Factors associated with PAS being unsuspected prior to delivery include a history of intrauterine adhesions, a history of clinically confirmed PAS, a posterior placenta, and a history of placenta previa. […] In conclusion, our data revealed that approximately one-third of PAS cases were not suspected during antenatal screening, and these unsuspected cases exhibited poorer outcomes compared to the suspected cases. Risk factors for lack of suspicion include a history of intrauterine adhesions, clinically confirmed PAS, posterior placenta, and placenta previa. Increasing awareness of these risk factors could facilitate early diagnosis of PAS and enhance maternal outcomes.
  • #36 Clinical Diagnosis of Placenta Accreta and Clinicopathological Outcomes
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7653210/
    Most patients undergoing cesarean hysterectomy for placenta accreta do have this diagnosis confirmed on pathology. […] However, since diagnosis of placenta accreta was made intraoperatively in nearly a third of cesarean hysterectomies, intraoperative vigilance is required as the need for cesarean hysterectomy may not be anticipated preoperatively. […] In conclusion, in our cohort, diagnosis of placenta accreta was first made intraoperatively in nearly a third of cesarean hysterectomies. While most patients undergoing cesarean hysterectomy for clinically diagnosed placenta accreta had the diagnosis confirmed on pathologic examination, there was a 4% false positive rate. […] These findings re-enforce the need for vigilance intraoperatively as the need for cesarean hysterectomy may not be anticipated preoperatively.
  • #37 Placenta Accreta Spectrum | ACOG
    https://www.acog.org/clinical/clinical-guidance/obstetric-care-consensus/articles/2018/12/placenta-accreta-spectrum
    Placenta accreta spectrum, formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, placenta percreta, and placenta accreta. Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion. […] Antenatal diagnosis of placenta accreta spectrum is highly desirable because outcomes are optimized when delivery occurs at a level III or IV maternal care facility before the onset of labor or bleeding and with avoidance of placental disruption. […] Delivery in highly experienced maternity centers that have this type of coordinated care team and the ability to garner additional expertise and resources in cases of severe hemorrhage appears to improve outcomes.