Materiały źródłowe

• #1 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10 to 15% of women of reproductive age and 35 to 50% of women with pelvic pain and/or infertility. […] The vast majority of cases of endometriosis occur in women between menarche and menopause. The peak of the disease falls in the period between 25 and 45 years of age. […] Literature data indicate that endometriosis is found in 0.15 to 3% of women operated on laparoscopically or by laparotomy, of which 12 to 32% are women after diagnostic laparoscopy due to pelvic pain delays and 10 to 60% of the patient after diagnostic laparoscopy due to disability.

• #2 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10–15% of women of reproductive age and 35–50% of women with pelvic pain and/or infertility. However, it should be noted that there are also cases of patients with endometriosis after menopause, and it also happens in adolescent women. […] Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a benign, estrogen-dependent, gynecological disease; however, due to the accompanying ailments and chronic nature, it is a very important medical, social and economic problem.

• #3 Time for global health policy and research leaders to prioritize endometriosis | Nature Communications

  https://www.nature.com/articles/s41467-023-43913-9

  Endometriosis is an incurable, under-diagnosed, systemic inflammatory disease affecting millions world-wide. […] Global public health policies are urgently needed to promote awareness, implement multidisciplinary care, and fund research for aetiology, biomarker discovery, and effective therapies for symptoms associated with endometriosis. […] Endometriosis affects ~10% of persons with a uterus, commonly striking teens and persisting across the reproductive life span (and sometimes beyond), greatly impacting personal relationships, educational and employment opportunities, and quality of life. […] There remains no reliable non-invasive biomarker of any endometriosis subtype. […] As delayed or undiagnosed endometriosis leads to compromised health, promoting awareness, improving access to care, and implementing multidisciplinary care paradigms are urgently needed in global public health policies. […] Equally urgent and important are prioritizing and committing resources to support fundamental research and biomarker discovery to shorten the protracted time to diagnosis and provide effective, long-term therapies for this chronic and debilitating disorder to the benefit of millions world-wide.

• #4 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10–15% of women of reproductive age and 35–50% of women with pelvic pain and/or infertility. However, it should be noted that there are also cases of patients with endometriosis after menopause, and it also happens in adolescent women. […] Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a benign, estrogen-dependent, gynecological disease; however, due to the accompanying ailments and chronic nature, it is a very important medical, social and economic problem.

• #5 Evaluation and Treatment of Endometriosis | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0115/p107.html

  Endometriosis is an estrogen-dependent disease predominantly affecting reproductive-aged women, with the highest incidence among women 25 to 29 years of age. The prevalence of endometriosis in the general population is difficult to accurately assess because some women with the disease have limited or no symptoms. Some studies suggest that it affects up to 10 percent of reproductive-aged women. Endometriosis is diagnosed in 21 to 40 percent of women with infertility and in 70 to 90 percent of women with chronic pelvic pain. […] In the United States, endometriosis is the third leading cause of gynecologic hospitalizations. It is estimated that the disease leads to $2,801 in health care costs and $1,023 in lost productivity at work per patient annually. In one nationwide survey, 50 percent of women with endometriosis reported spending entire days in bed over the previous 12 months because of the condition, with an average of 17.8 days spent in bed.

• #6 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  Endometriosis occurs in 6-10% of US women in the general population, and approximately 4 per 1000 women are hospitalized with this condition each year. […] The exact incidence in the general population is unknown, because the definitive diagnosis requires biopsy or visualization of the endometriotic implants at laparoscopy or laparotomy. Most prevalence studies are based on a surgical population in which the likelihood of disease is greater, with the best estimates of incidence in the general female coming from women with proven fertility undergoing tubal sterilization procedures. […] Endometriosis is an estrogen-dependent disease and, thus, usually affects reproductive-aged women. This condition has a prevalence rate of 20-50% in infertile women, but it can be as high as 71-87% in women with chronic pelvic pain.

• #7 Epidemiology of deep endometriosis – gynsurgery.org

  https://www.gynsurgery.org/endometriosis/epidemiology-of-endometriosis/

  Epidemiology of endometriosis is important to learn about the cause of endometriosis. […] Endometriosis epidemiology is important since the prevalence and severity of endometriosis might be linked to pollution and to our modern lifestyle, comprising food intake, chemical disruptors, postponement of the first pregnancy, and stress, as indicated by “a career women’s disease”. Most important is that understanding if and why prevalence and severity are increasing would permit prevention. […] We did know very little since endometriosis epidemiology studies are based upon hospital discharge records. Our review explains why these observations are biased and cannot be trusted. Moreover a distinction between subtle and typical and cystic and deep endometriosis was not made. […] All deep endometriosis surgeons strongly feel that the prevalence and the severity of deep endometriosis is increasing. In South Italy deep endometriosis is actually very frequent although very rare 20 years ago. To the best of our knowledge this are the best data available today.

• #8 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Endometriosis affects 10-15% of all women of reproductive age and 70% of women with chronic pelvic pain. […] Unfortunately, for many of these women there is often a delay in diagnosis of endometriosis resulting in unnecessary suffering and reduced quality of life. […] Despite recent advances in identifying risk factors for endometriosis, the field continues to be limited by requiring surgical diagnosis of the disease, often done laparoscopically to confirm affected cases and appropriate controls. […] Ultimately, the establishment of a defined set of endometriosis risk factors could lead to the identification of a group of women and girls with a high enough risk profile to warrant screening. […] Despite the range of blood tests that have been evaluated, a reliable test has yet to be identified for the diagnosis of endometriosis.

• #9

  https://www.who.int/news-room/fact-sheets/detail/endometriosis

  Endometriosis affects roughly 10% (190 million) of reproductive age women and girls globally. […] Access to early diagnosis and effective treatment of endometriosis is important, but is limited in many settings, including in low- and middle-income countries. […] Endometriosis is a complex disease that affects many women globally from the onset of their first period (menarche) through menopause, regardless of ethnic origin or social status. […] In many countries, the general public and most front-line healthcare providers are not aware that distressing and life-altering pelvic pain is not normal, leading to a normalization and stigmatization of symptoms and significant diagnostic delay. […] Due to diagnostic delays, prompt access to available treatment methods, including non-steroidal analgesics (painkillers), oral contraceptives and progestin-based contraceptives is often not achieved. […] WHO is also collaborating with relevant stakeholders to facilitate and support the collection and analysis of country- and region-specific endometriosis prevalence data for decision making.

• #10 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10 to 15% of women of reproductive age and 35 to 50% of women with pelvic pain and/or infertility. […] The vast majority of cases of endometriosis occur in women between menarche and menopause. The peak of the disease falls in the period between 25 and 45 years of age. […] Literature data indicate that endometriosis is found in 0.15 to 3% of women operated on laparoscopically or by laparotomy, of which 12 to 32% are women after diagnostic laparoscopy due to pelvic pain delays and 10 to 60% of the patient after diagnostic laparoscopy due to disability.

• #11 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  Endometriosis occurs in 6-10% of US women in the general population, and approximately 4 per 1000 women are hospitalized with this condition each year. […] The exact incidence in the general population is unknown, because the definitive diagnosis requires biopsy or visualization of the endometriotic implants at laparoscopy or laparotomy. Most prevalence studies are based on a surgical population in which the likelihood of disease is greater, with the best estimates of incidence in the general female coming from women with proven fertility undergoing tubal sterilization procedures. […] Endometriosis is an estrogen-dependent disease and, thus, usually affects reproductive-aged women. This condition has a prevalence rate of 20-50% in infertile women, but it can be as high as 71-87% in women with chronic pelvic pain.

• #12 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10–15% of women of reproductive age and 35–50% of women with pelvic pain and/or infertility. However, it should be noted that there are also cases of patients with endometriosis after menopause, and it also happens in adolescent women. […] Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a benign, estrogen-dependent, gynecological disease; however, due to the accompanying ailments and chronic nature, it is a very important medical, social and economic problem.

• #13 Endometriosis Epidemiology Forecast Report 2021-2030 – Focus on US, France, Germany, Italy, Spain, UK, and Japan – ResearchAndMarkets.com

  https://www.businesswire.com/news/home/20220215005831/en/Endometriosis-Epidemiology-Forecast-Report-2021-2030—Focus-on-US-France-Germany-Italy-Spain-UK-and-Japan—ResearchAndMarkets.com

  Endometriosis Epidemiology Forecast Report 2021-2030 – Focus on US, France, Germany, Italy, Spain, UK, and Japan – ResearchAndMarkets.com […] The „Endometriosis – Epidemiology Forecast to 2030” report has been added to ResearchAndMarkets.com’s offering. […] This report provides an overview of the risk factors, comorbidities, and the global and historical epidemiological trends for endometriosis in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan). […] The report includes a 10-year epidemiology forecast for the diagnosed prevalent cases of endometriosis. The diagnosed prevalent cases of endometriosis are segmented by age (12-54 years) and laparoscopy confirmation status (whether suspected or confirmed endometriosis). […] The following data describes epidemiology of endometriosis. In the 7MM, The publisher epidemiologists forecast a decrease in the diagnosed prevalent cases of endometriosis from 3,317,609 cases in 2020 to 3,232,223 cases in 2030, at an AGR of -0.26% over the forecast period. Younger adult women are predominantly affected.

• #14 Endometriosis: Epidemiology Forecast to 2030 – Market Research Reports & Consulting | GlobalData UK Ltd.

  https://www.globaldata.com/store/report/endometriosis-epidemiology-analysis/

  The diagnosed prevalent cases of endometriosis in the seven major markets (7MM) are expected to decrease from 3,317,609 cases in 2020 at a negative annual growth rate (AGR) of more than 0.20% by 2030. […] In 2020, out of the diagnosed prevalent cases of endometriosis in the 7MM, confirmed cases (with laparoscopy) contributed the higher proportion with more than 65%, while suspected cases (without laparoscopy) contributed more than 30%. […] In 2020, out of the diagnosed prevalent cases of endometriosis in the 7MM, stage IV (severe) contributed the highest proportion with more than 30% cases, while stage I (minimal) contributed more than 25% cases, stage III (moderate) contributed more than 20% cases, and stage II (mild) contributed more than 15% cases. […] In 2020, the US accounted for more than 40% of the diagnosed prevalent cases of endometriosis in the 7MM. There were 1,809,786 cases in the 5EU in 2020, or more than 50% of the diagnosed prevalent cases, while Japan had more than 3% cases. […] The diagnosed prevalent cases of endometriosis in the seven major markets (7MM) are expected to decrease at a negative annual growth rate (AGR) of more than 0.2%.

• #15 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #16 Endometriosis 101: A Disease Profile

  https://www.managedhealthcareexecutive.com/view/endometriosis-101-a-disease-profile

  Endometriosis, the chronic inflammatory, sex-steroid-based reproductive disease, affects approximately 10% of women worldwide, including 9 million women in the United States, according to a research review paper published in JAMA this week. […] A team of researchers, including corresponding author Sawsan As-Sanie, M.D., M.P.H., from the obstetrics and gynecology department at the University of Michigan, included 99 studies in their review of endometriosis epidemiology, pathophysiology, diagnosis and treatment. […] Endometriosis diagnosis is often delayed anywhere from five to 12 years after symptom onset, usually seen in adolescence or the womans early 20s. On average, women are evaluated by three physicians before receiving their diagnosis. […] In the United States, it accounts for approximately $78 billion in annual health care costs. This includes treatment and wages lost from missing work.

• #17 Epidemiology of Endometriosis in Spain and Its – ProQuest

  https://www.proquest.com/scholarly-journals/epidemiology-endometriosis-spain-autonomous/docview/2558813436/se-2

  Endometriosis is a painful disorder characterized by the presence of endometrial glands and stroma outside of the uterine cavity. Estimates of the incidence of endometriosis suggest that it could affect up to 10% of women of reproductive age worldwide and approximately 30-50% of women with symptoms suggestive of endometriosis, but the limitations of these estimates are that they are usually determined based on data from patients. The true incidence of endometriosis in a global and community setting has not yet been determined, and information from epidemiological studies on endometriosis is limited. […] The objective of this study was to assess the incidence of diagnosed endometriosis in the general population in Spain and in 19 Spanish autonomous communities. […] The overall incidence of endometriosis in Spain was 16.1 cases per 10,000 women, and the rates ranged from 6.8 to 24 per 10,000 women among the autonomous communities, with the incidence of endometriosis being higher in Valencian (24), Navarre (22.6), Catalonia (20), Extremadura (19.5) and Murcia (18.4). […] This study also provides information on the relative proportions of the different types of endometriosis. Further studies are needed to assess the reasons for the increasing incidence of endometriosis and for the significant differences in the regional incidence of this disease.

• #18 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #19 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from €0.8 billion to €12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Literature data indicate that endometriosis is found in 0.1–53% of women operated on laparoscopically or by laparotomy, of which 12–32% are women after diagnostic laparoscopy due to pelvic pain delays and 10–60% of the patient after diagnostic laparoscopy due to disability. […] The presence of lateral parametrial endometriosis (LPE) can be considered a reflection of a more severe disease, ureteral stenosis and dilatation, and voiding dysfunctions, mainly because of the involvement of the inferior hypogastric plexus.

• #20 An Overlooked Condition: Addressing Endometriosis Disparities in Healthcare – American Medical Women’s Association

  https://www.amwa-doc.org/an-overlooked-condition-addressing-endometriosis-disparities-in-healthcare/

  Endometriosis is a chronic and often debilitating condition that affects approximately 10-15% of women of reproductive age in the United States (Parasar et al., 2017). […] Despite its widespread prevalence, endometriosis remains underdiagnosed and undertreated, particularly in underserved and underrepresented communities, such as rural women and Black and Hispanic women, where systemic healthcare disparities contribute to delayed diagnosis and limited treatment options (Bougie et al., 2022; Orlando et al., 2022). […] Racial and ethnic disparities in endometriosis diagnosis and treatment remain a significant concern. […] For example, Black women have been underdiagnosed due to the longstanding misconception that endometriosis is rare in this population (Bougie et al., 2022). […] Additionally, recent research indicates that Asian and Pacific Islander women may experience higher rates of endometriosis than previously recognized (Bougie et al., 2022).

• #21 An Overlooked Condition: Addressing Endometriosis Disparities in Healthcare – American Medical Women’s Association

  https://www.amwa-doc.org/an-overlooked-condition-addressing-endometriosis-disparities-in-healthcare/

  Endometriosis is a chronic and often debilitating condition that affects approximately 10-15% of women of reproductive age in the United States (Parasar et al., 2017). […] Despite its widespread prevalence, endometriosis remains underdiagnosed and undertreated, particularly in underserved and underrepresented communities, such as rural women and Black and Hispanic women, where systemic healthcare disparities contribute to delayed diagnosis and limited treatment options (Bougie et al., 2022; Orlando et al., 2022). […] Racial and ethnic disparities in endometriosis diagnosis and treatment remain a significant concern. […] For example, Black women have been underdiagnosed due to the longstanding misconception that endometriosis is rare in this population (Bougie et al., 2022). […] Additionally, recent research indicates that Asian and Pacific Islander women may experience higher rates of endometriosis than previously recognized (Bougie et al., 2022).

• #22

  https://www.who.int/news-room/fact-sheets/detail/endometriosis

  Endometriosis affects roughly 10% (190 million) of reproductive age women and girls globally. […] Access to early diagnosis and effective treatment of endometriosis is important, but is limited in many settings, including in low- and middle-income countries. […] Endometriosis is a complex disease that affects many women globally from the onset of their first period (menarche) through menopause, regardless of ethnic origin or social status. […] In many countries, the general public and most front-line healthcare providers are not aware that distressing and life-altering pelvic pain is not normal, leading to a normalization and stigmatization of symptoms and significant diagnostic delay. […] Due to diagnostic delays, prompt access to available treatment methods, including non-steroidal analgesics (painkillers), oral contraceptives and progestin-based contraceptives is often not achieved. […] WHO is also collaborating with relevant stakeholders to facilitate and support the collection and analysis of country- and region-specific endometriosis prevalence data for decision making.

• #23 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10 to 15% of women of reproductive age and 35 to 50% of women with pelvic pain and/or infertility. […] The vast majority of cases of endometriosis occur in women between menarche and menopause. The peak of the disease falls in the period between 25 and 45 years of age. […] Literature data indicate that endometriosis is found in 0.15 to 3% of women operated on laparoscopically or by laparotomy, of which 12 to 32% are women after diagnostic laparoscopy due to pelvic pain delays and 10 to 60% of the patient after diagnostic laparoscopy due to disability.

• #24 Evaluation and Treatment of Endometriosis | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0115/p107.html

  Endometriosis is an estrogen-dependent disease predominantly affecting reproductive-aged women, with the highest incidence among women 25 to 29 years of age. The prevalence of endometriosis in the general population is difficult to accurately assess because some women with the disease have limited or no symptoms. Some studies suggest that it affects up to 10 percent of reproductive-aged women. Endometriosis is diagnosed in 21 to 40 percent of women with infertility and in 70 to 90 percent of women with chronic pelvic pain. […] In the United States, endometriosis is the third leading cause of gynecologic hospitalizations. It is estimated that the disease leads to $2,801 in health care costs and $1,023 in lost productivity at work per patient annually. In one nationwide survey, 50 percent of women with endometriosis reported spending entire days in bed over the previous 12 months because of the condition, with an average of 17.8 days spent in bed.

• #25 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  In a large series involving adolescent females with chronic pelvic pain, 45% were found to have endometriosis at laparoscopy. Of note, only 25% had a normal pelvis. In that series, the rate of endometriosis was found to increase with age from 12% in females aged 11-13 years to 45% in females aged 20-21 years. […] A more recent systematic review and meta-analysis revealed a high prevalence of endometriosis among adolescent females with pelvic pain. Of 1011 symptomatic adolescents who underwent laparoscopic investigation, 648 (64%) were found to have endometriosis. […] A familial association exists, with a 10-fold increased incidence in women with an affected first-degree relative. […] Monozygotic twins are markedly concordant for endometriosis.

• #26 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  In a large series involving adolescent females with chronic pelvic pain, 45% were found to have endometriosis at laparoscopy. Of note, only 25% had a normal pelvis. In that series, the rate of endometriosis was found to increase with age from 12% in females aged 11-13 years to 45% in females aged 20-21 years. […] A more recent systematic review and meta-analysis revealed a high prevalence of endometriosis among adolescent females with pelvic pain. Of 1011 symptomatic adolescents who underwent laparoscopic investigation, 648 (64%) were found to have endometriosis. […] A familial association exists, with a 10-fold increased incidence in women with an affected first-degree relative. […] Monozygotic twins are markedly concordant for endometriosis.

• #27 Epidemiology of endometriosis in UK adolescents – Ego Journal

  https://egojournal.eu/journal/2020-04/epidemiology-of-endometriosis-in-uk-adolescents/

  Epidemiology of endometriosis in UK adolescents […] Background and Purpose: To estimate the incidence of clinically diagnosed and surgically confirmed endometriosis in UK adolescents (age 10-17) from 2006-2016. […] Methods: This retrospective cohort study included adolescents enrolled in the Clinical Practice Research Datalink (CPRD GOLD) during the study period. Additionally, hospital episode statistics (HES) data were linked to CPRD GOLD for eligible patients and provided surgical confirmation of endometriosis. READ and International Classification of Disease (ICD-10)/ Office of Population Censuses and Surveys (OPCS) codes were used to identify cases of endometriosis in CPRD GOLD and HES, respectively. Cases of clinically diagnosed endometriosis were considered surgically confirmed if a procedure during which endometriosis could be visualized occurred within 1 year of the date that endometriosis codes were first entered in the patients medical record. […] Results: The most commonly reported symptoms, recorded in adolescents medical records, in the sample of 15 to 17-year-old female adolescents were abdominal pain (3.7%) and dysmenorrhea (2.3%). The incidence per 100,000 women-years of clinically diagnosed endometriosis, in adolescents age 15-17 years was 13.65 (95% CI: 11.42-16.19), with more of the cases occurring (93%) at this range of age. The incidence of surgically confirmed endometriosis in adolescents age 15-17 years was 8.09 (95% CI: 5.86-10.90), with 98% of cases occurring in the older age group 15-17 years of age. […] Conclusions: Endometriosis was infrequently diagnosed in this population-based sample of adolescents age 10-17 years in the UK and diagnosis mostly occurred in those 15-17 years or older. In accordance with clinical guidelines, there was limited surgical confirmation of endometriosis in this adolescent population. Increased diagnosis of suspected endometriosis in adolescents can lead to treatment and potentially better outcomes for young women experiencing this disease.

• #28 Epidemiology of subtle, typical, cystic, and deep endometriosis: a systematic review | Gynecological Surgery | Full Text

  https://gynecolsurg.springeropen.com/articles/10.1007/s10397-016-0970-4

  Endometriosis is known as a cause of pelvic pain and infertility. The epidemiology of endometriosis is important since the prevalence and severity of endometriosis might be linked to pollution and to our modern lifestyle, comprising food intake, chemical disruptors, postponement of the first pregnancy, and stress, as indicated by a career womens disease. […] The only data found were that severe endometriosis carries a greater hereditary risk and that the prevalence of subtle endometriosis decreases with age whereas the prevalences of typical, cystic, and deep endometriosis increase with age. […] In conclusion, there are no solid epidemiologic data of each type of endometriosis separately. […] The investigation of the epidemiology of deep endometriosis is suggested since it is relevant because it is clinically severe pathologic and feasible since it can be done from hospital-based records.

• #29 Epidemiology of subtle, typical, cystic, and deep endometriosis: a systematic review | Gynecological Surgery | Full Text

  https://gynecolsurg.springeropen.com/articles/10.1007/s10397-016-0970-4

  With all restrictions imposed by the inherent selection bias in Leuven in 1991, in a group of 900 women with pain and/or infertility, 49 % had subtle lesions, 29 % had typical lesions, 31 % had cystic ovarian endometriosis, and 18 % had deep endometriosis. […] Although the total incidence remained constant with age at some 71 %, subtle lesions significantly decreased with age whereas typical cystic and deep lesions increased with age. […] Endometriosis is a hereditary disease as evidenced by the seven times higher prevalences in first-degree relatives and the high associations in monozygotic. […] There is no evidence that the prevalence of cystic ovarian endometriosis is increasing. […] The recognition of smaller deep endometriosis lesions only started in the 1990s, and all reports do have a referral bias.

• #30 Epidemiology of subtle, typical, cystic, and deep endometriosis: a systematic review | Gynecological Surgery | Full Text

  https://gynecolsurg.springeropen.com/articles/10.1007/s10397-016-0970-4

  With all restrictions imposed by the inherent selection bias in Leuven in 1991, in a group of 900 women with pain and/or infertility, 49 % had subtle lesions, 29 % had typical lesions, 31 % had cystic ovarian endometriosis, and 18 % had deep endometriosis. […] Although the total incidence remained constant with age at some 71 %, subtle lesions significantly decreased with age whereas typical cystic and deep lesions increased with age. […] Endometriosis is a hereditary disease as evidenced by the seven times higher prevalences in first-degree relatives and the high associations in monozygotic. […] There is no evidence that the prevalence of cystic ovarian endometriosis is increasing. […] The recognition of smaller deep endometriosis lesions only started in the 1990s, and all reports do have a referral bias.

• #31 Endometriosis: Epidemiology Forecast to 2030 – Market Research Reports & Consulting | GlobalData UK Ltd.

  https://www.globaldata.com/store/report/endometriosis-epidemiology-analysis/

  The diagnosed prevalent cases of endometriosis in the seven major markets (7MM) are expected to decrease from 3,317,609 cases in 2020 at a negative annual growth rate (AGR) of more than 0.20% by 2030. […] In 2020, out of the diagnosed prevalent cases of endometriosis in the 7MM, confirmed cases (with laparoscopy) contributed the higher proportion with more than 65%, while suspected cases (without laparoscopy) contributed more than 30%. […] In 2020, out of the diagnosed prevalent cases of endometriosis in the 7MM, stage IV (severe) contributed the highest proportion with more than 30% cases, while stage I (minimal) contributed more than 25% cases, stage III (moderate) contributed more than 20% cases, and stage II (mild) contributed more than 15% cases. […] In 2020, the US accounted for more than 40% of the diagnosed prevalent cases of endometriosis in the 7MM. There were 1,809,786 cases in the 5EU in 2020, or more than 50% of the diagnosed prevalent cases, while Japan had more than 3% cases. […] The diagnosed prevalent cases of endometriosis in the seven major markets (7MM) are expected to decrease at a negative annual growth rate (AGR) of more than 0.2%.

• #32 Endometriosis Epidemiology Forecast Report 2021-2030 – Focus on US, France, Germany, Italy, Spain, UK, and Japan – ResearchAndMarkets.com

  https://www.businesswire.com/news/home/20220215005831/en/Endometriosis-Epidemiology-Forecast-Report-2021-2030—Focus-on-US-France-Germany-Italy-Spain-UK-and-Japan—ResearchAndMarkets.com

  The Endometriosis Epidemiology Report provides an overview of the risk factors and global trends of Endometriosis in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan). […] The report includes a 10-year epidemiology forecast for the diagnosed prevalent cases of endometriosis. The diagnosed prevalent cases of endometriosis are segmented by age (12-54 years) and laparoscopy confirmation status (whether suspected or confirmed endometriosis). The report also includes the diagnosed prevalent cases of endometriosis further segmented by ASRM stage and classified as Stage I (Minimal), Stage II (Mild), Stage III (Moderate), or Stage IV (Severe); phenotype: Superficial Peritoneal Endometriosis (SUP), Ovarian Endometrioma (OMA), and Deep Infiltrating Endometriosis (DIE); cases undergoing laparoscopy; and comorbidities such as chronic pelvic pain (CPP), dysmenorrhea, and dyspareunia.

• #33 Epidemiology of Bowel Endometriosis | SpringerLink

  https://link.springer.com/chapter/10.1007/978-3-030-50446-5_2

  Several methodological issues complicate the assessment of the epidemiology of endometriosis such as the need for surgery in order to establish the diagnosis and the presence of selection bias as the patients with symptomatic disease are more likely to require diagnostic instruments and surgery. […] Retrospective studies including patients undergoing surgery for deep infiltrating endometriosis reported that about a quarter of these patients have bowel endometriosis. […] Rectum and rectosigmoid junction are the most common disease localizations, affecting up to three quarters of the patients with bowel endometriosis followed by the sigmoid colon. […] However, endometriotic nodules can also be found in the appendix, terminal ileum, descending colon, transverse colon, and stomach. […] Epidemiology of endometriosis.

• #34 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from €0.8 billion to €12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Literature data indicate that endometriosis is found in 0.1–53% of women operated on laparoscopically or by laparotomy, of which 12–32% are women after diagnostic laparoscopy due to pelvic pain delays and 10–60% of the patient after diagnostic laparoscopy due to disability. […] The presence of lateral parametrial endometriosis (LPE) can be considered a reflection of a more severe disease, ureteral stenosis and dilatation, and voiding dysfunctions, mainly because of the involvement of the inferior hypogastric plexus.

• #35 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Endometriosis affects 10-15% of all women of reproductive age and 70% of women with chronic pelvic pain. […] Unfortunately, for many of these women there is often a delay in diagnosis of endometriosis resulting in unnecessary suffering and reduced quality of life. […] Despite recent advances in identifying risk factors for endometriosis, the field continues to be limited by requiring surgical diagnosis of the disease, often done laparoscopically to confirm affected cases and appropriate controls. […] Ultimately, the establishment of a defined set of endometriosis risk factors could lead to the identification of a group of women and girls with a high enough risk profile to warrant screening. […] Despite the range of blood tests that have been evaluated, a reliable test has yet to be identified for the diagnosis of endometriosis.

• #36 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #37 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  In a large series involving adolescent females with chronic pelvic pain, 45% were found to have endometriosis at laparoscopy. Of note, only 25% had a normal pelvis. In that series, the rate of endometriosis was found to increase with age from 12% in females aged 11-13 years to 45% in females aged 20-21 years. […] A more recent systematic review and meta-analysis revealed a high prevalence of endometriosis among adolescent females with pelvic pain. Of 1011 symptomatic adolescents who underwent laparoscopic investigation, 648 (64%) were found to have endometriosis. […] A familial association exists, with a 10-fold increased incidence in women with an affected first-degree relative. […] Monozygotic twins are markedly concordant for endometriosis.

• #38 Endometriosis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/271899-overview

  In a large series involving adolescent females with chronic pelvic pain, 45% were found to have endometriosis at laparoscopy. Of note, only 25% had a normal pelvis. In that series, the rate of endometriosis was found to increase with age from 12% in females aged 11-13 years to 45% in females aged 20-21 years. […] A more recent systematic review and meta-analysis revealed a high prevalence of endometriosis among adolescent females with pelvic pain. Of 1011 symptomatic adolescents who underwent laparoscopic investigation, 648 (64%) were found to have endometriosis. […] A familial association exists, with a 10-fold increased incidence in women with an affected first-degree relative. […] Monozygotic twins are markedly concordant for endometriosis.

• #39 Epidemiology of Endometriosis

  https://www.contemporaryobgyn.net/view/epidemiology-endometriosis

  The prevalence of endometriosis is undoubtedly high, certainly in women with pain and or infertility. Estimations of subtle endometriosis range from 5 to 50 and from 50 to 80% in asymptomatic or symptomatic women respectively. For typical lesions, estimations are less than half of these figures, but the data have been collected before 1985. For severe endometriosis either cystic or deep, estimations in the population range between 1 and 10%. […] The prevalence of first degree relatives is some 7 times higher than in control groups. In monozygotic twins the prevalence is even up to 15 times higher. […] The increased awareness of deep endometriosis has increased the apparent prevalence over the years. The recognition that the small lesions tend to go unnoticed even during laparoscopy, because of lack of performing diagnostic methods, leads to the conclusion that the prevalence of deep endometriosis is underreported. This is especially important in studies concerning pelvic pain.

• #40 Endometriosis: new findings shed light on the cause

  https://www.polytechnique-insights.com/en/columns/health-and-biotech/endometriosis-the-origins-of-the-disease-become-clearer/

  Endometriosis is a burden for a substantial number of women and those assigned female at birth (AFAB). This inflammatory disease, which touches about 1 in 10 women of reproductive age globally, can cause debilitating chronic pain and poor fertility and was recently found to be linked to a whole host of comorbidities. […] Endometriosis has historically been overlooked but there’s been a recent surge of interest from research labs and groundbreaking advances are starting to emerge. […] We’ve known for a long time that endometriosis can run in families about 50% of disease risk in the general population is attributable to genetic factors, which is a sizable heritability. […] Endometriosis is a complex disease, which means that genetic factors and environmental factors and other aspects we don’t quite understand yet all contribute to risk.

• #41

  https://journals.lww.com/epidem/fulltext/1998/09000/characteristics_related_to_the_prevalence_of.6.aspx

  The objective of this case-control study is to identify factors associated with the prevalence of minimal or mild endometriosis among infertile women. The prevalence of minimal or mild endometriosis was higher in women age 25 years or older, in those who reported menarche at the age of 13 years or older, menstrual cycles of 27 days or less, or caffeine intake of 300 mg per day or more. The prevalence of minimal or mild endometriosis was inversely related to body mass index. Parous women were less likely to have endometriosis than were nulliparous women. Education, duration of infertility, and smoking status were not related to the presence of endometriosis.

• #42 Developmental origins of endometriosis: a Swedish cohort study | Journal of Epidemiology & Community Health

  https://jech.bmj.com/content/73/4/353

  Endometriosis is a chronic condition affecting women of reproductive age and is associated with multiple health burdens. The reported prevalence of endometriosis varies between 2% and 5% in the general female population, with an estimated 0.1% annual incidence among reproductive-aged women. The true occurrence of endometriosis is unclear, due to variations in clinical presentations, diagnostic criteria and many asymptomatic cases. […] During the follow-up, 111 women have been diagnosed with endometriosis, and most cases are external endometriosis (ie, outside the uterus, n=91). Lower standardised birth weight for gestational age was associated with increased rate of endometriosis (HR 1.35 per standard deviation decrease; 95% CI 1.08 to 1.67). This increased rate was also detected among women with fewer number of live births (HR 2.38; 95% CI 1.40 to 4.07 for one child vs 2 children; HR 6.09; 95% CI 3.88 to 9.57 for no child vs 2 children) and diagnosed infertility problem (HR 2.00; 95% CI 1.10 to 3.61) prior to endometriosis diagnosis. […] This study supports the developmental origins theory and suggests that exposure to growth restriction during the fetal period is associated with increased risk of endometriosis during reproductive years.

• #43 Endometriosis in the Black Women’s Health Study | Slone Epidemiology Center

  https://www.bu.edu/slone/research/studies/endometriosis/

  Little is known about the incidence of endometriosis among Black women. Endometriosis is characterized by the presence of endometrial tissue external to the uterine cavity and is common among reproductive-aged women. […] We have been funded to study novel risk factors for endometriosis in both Black and White women, pooling data from the Black Womens Health Study (BWHS) and Nurses Health Study (NHS), two large prospective cohort studies of U.S. women. Risk factors of interest include autoimmune diseases, hypertension, hypercholesterolemia, type 2 diabetes, myocardial infarction, ischemic stroke, reproductive, and hormonal factors.

• #44 Endometriosis 101: A Disease Profile

  https://www.managedhealthcareexecutive.com/view/endometriosis-101-a-disease-profile

  Endometriosis, the chronic inflammatory, sex-steroid-based reproductive disease, affects approximately 10% of women worldwide, including 9 million women in the United States, according to a research review paper published in JAMA this week. […] A team of researchers, including corresponding author Sawsan As-Sanie, M.D., M.P.H., from the obstetrics and gynecology department at the University of Michigan, included 99 studies in their review of endometriosis epidemiology, pathophysiology, diagnosis and treatment. […] Endometriosis diagnosis is often delayed anywhere from five to 12 years after symptom onset, usually seen in adolescence or the womans early 20s. On average, women are evaluated by three physicians before receiving their diagnosis. […] In the United States, it accounts for approximately $78 billion in annual health care costs. This includes treatment and wages lost from missing work.

• #45 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Current guidelines recommend that the histological examination of specimens collected from the suspicious areas during the visual inspection of the pelvis at laparoscopy is the gold standard for diagnosis of endometriosis. […] A semi/non-invasive diagnostic biomarker would be a useful tool to identify patients early in the disease process and thus improving outcomes, including less pain and better fertility.

• #46 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Endometriosis affects 10-15% of all women of reproductive age and 70% of women with chronic pelvic pain. […] Unfortunately, for many of these women there is often a delay in diagnosis of endometriosis resulting in unnecessary suffering and reduced quality of life. […] Despite recent advances in identifying risk factors for endometriosis, the field continues to be limited by requiring surgical diagnosis of the disease, often done laparoscopically to confirm affected cases and appropriate controls. […] Ultimately, the establishment of a defined set of endometriosis risk factors could lead to the identification of a group of women and girls with a high enough risk profile to warrant screening. […] Despite the range of blood tests that have been evaluated, a reliable test has yet to be identified for the diagnosis of endometriosis.

• #47 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  The time from the appearance of the first symptoms of the disease to the diagnosis is up to 8 to 10 years. […] Despite such frequent occurrence of this disease, the mechanism of its formation remains unexplained, and a good marker of this disease has still not been discovered. […] The only markers that have found partial clinical use in the diagnosis of endometriosis are the glycoproteins Ca-125 and Ca-19-9. The sensitivity of Ca-125 is characteristic of the advanced form of the disease, but its specificity is low because it is often elevated in other gynecological diseases.

• #48 Real world data on symptomology and diagnostic approaches of 27,840 women living with endometriosis | Scientific Reports

  https://www.nature.com/articles/s41598-021-99681-3

  Overall, endometriosis was diagnosed in 87.8% of women based on clinical symptoms. Diagnosis based on clinical symptoms was most frequently reported in Russia (94.1%), followed by Hungary (88.0%). In contrast, surgical-based diagnosis was most common in Germany (38.1%) and Poland (34.5%). Overall, 69.6% of women were reported to have received diagnosis of endometriosis within the first year after the occurrence of their first endometriosis symptoms. […] Women in VIPOS most commonly reported heavy/irregular bleeding, painful periods, and pelvic pain, followed by tiredness/weakness. In addition, most women experienced at least one of three pain symptoms typically associated with endometriosis (pelvic pain, pain after/during sexual intercourse, and painful menstrual bleeding), and more than 50% of women overall reported an impact on mood due to endometriosis.

• #49 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://www.mdpi.com/1422-0067/22/19/10554

  The time from the appearance of the first symptoms of the disease to the diagnosis is up to 8 to 10 years. […] Despite such frequent occurrence of this disease, the mechanism of its formation remains unexplained, and a good marker of this disease has still not been discovered. […] The only markers that have found partial clinical use in the diagnosis of endometriosis are the glycoproteins Ca-125 and Ca-19-9. The sensitivity of Ca-125 is characteristic of the advanced form of the disease, but its specificity is low because it is often elevated in other gynecological diseases.

• #50 Pilot study MOVENDOP protocol – impact on quality of life following postoperative osteopathic abdominal mobilizations in patients operated for endometriosis | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323214

  Endometriosis, characterized by the presence of endometrial-like tissue outside the uterine cavity associated with chronic inflammation, affects approximately 510% of women of reproductive age. This disease was first described in 1690 and primary symptoms outlined in 1769, but remains a complex and poorly understood disease. Endometriosis symptoms are highly heterogeneous, with the most common triad being dysmenorrhea, dyspareunia and chronic pelvic pain. These symptoms can severely impair quality of life (QoL) and contribute to infertility, as previously documented. […] To assess the impact of endometriosis on QoL, several validated scales have been developed. Among these, the generic multidimensional SF-36 questionnaire and the disease-specific EHP-30 scale are the most widely used tools in endometriosis research. Diagnosis and management of endometriosis however, remain challenging, with an average period of 78 years between the onset of symptoms and diagnosis, depending on disease severity.

• #51 Epidemiology, Pathophysiology, and Diagnosis of Endometriosis

  https://www.consultant360.com/podcasts/epidemiology-pathophysiology-and-diagnosis-endometriosis

  In part 2 of this 2-part episode, Dan Martin, MD, speaks about his team’s research titled „The Epidemiology of Endometriosis is Poorly Known as the Pathophysiology and Diagnosis are Unclear,” including the gaps in endometriosis research, why those gaps are so problematic, and the key takeaways from their research. […] According to the Endometriosis Foundation of America, endometriosis is one of the leading causes in infertility, and on average, there is a seven to 10-year delay in diagnosis. […] Well, without knowing which specific phenotypes of endometriosis have different biologic behaviors, we don’t really know how many types of endometriosis we need to study. […] Endometriosis is likely more than one disease, and we need more than one standardized definition and more than one or two standard treatments. Women need early proactive treatment and planning so that they can potentially limit the growth of endometriosis and avoid surgery.

• #52 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Missed-or-Delayed-Diagnosis-of-Endometriosis.aspx

  Although the exact prevalence of endometriosis is unknown, population estimations place it between 2% and 10% of women, and as high as 50% in women with infertility. Globally, endometriosis affects approximately 176 million women and is the second most common gynecological condition after fibroids. […] Despite this, it takes an average of eight years from the onset of symptoms to receive a diagnosis. This is due, in part, to the clinical challenge posed by a lack of non-invasive diagnostic techniques. Owing to the low correlation between symptoms such as tissue scarring and disease burden, techniques such as ultrasound are non-effective, and a reliable test for blood biomarkers for the condition is yet to be evaluated. […] The current gold standard is via laparoscopy, a surgical procedure that is recommended only in the event of failed therapeutic intervention for chronic pelvic pain.

• #53 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #54 Endometriosis 101: A Disease Profile

  https://www.managedhealthcareexecutive.com/view/endometriosis-101-a-disease-profile

  Endometriosis, the chronic inflammatory, sex-steroid-based reproductive disease, affects approximately 10% of women worldwide, including 9 million women in the United States, according to a research review paper published in JAMA this week. […] A team of researchers, including corresponding author Sawsan As-Sanie, M.D., M.P.H., from the obstetrics and gynecology department at the University of Michigan, included 99 studies in their review of endometriosis epidemiology, pathophysiology, diagnosis and treatment. […] Endometriosis diagnosis is often delayed anywhere from five to 12 years after symptom onset, usually seen in adolescence or the womans early 20s. On average, women are evaluated by three physicians before receiving their diagnosis. […] In the United States, it accounts for approximately $78 billion in annual health care costs. This includes treatment and wages lost from missing work.

• #55 Evaluation and Treatment of Endometriosis | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0115/p107.html

  Endometriosis is an estrogen-dependent disease predominantly affecting reproductive-aged women, with the highest incidence among women 25 to 29 years of age. The prevalence of endometriosis in the general population is difficult to accurately assess because some women with the disease have limited or no symptoms. Some studies suggest that it affects up to 10 percent of reproductive-aged women. Endometriosis is diagnosed in 21 to 40 percent of women with infertility and in 70 to 90 percent of women with chronic pelvic pain. […] In the United States, endometriosis is the third leading cause of gynecologic hospitalizations. It is estimated that the disease leads to $2,801 in health care costs and $1,023 in lost productivity at work per patient annually. In one nationwide survey, 50 percent of women with endometriosis reported spending entire days in bed over the previous 12 months because of the condition, with an average of 17.8 days spent in bed.

• #56 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #57 An Overlooked Condition: Addressing Endometriosis Disparities in Healthcare – American Medical Women’s Association

  https://www.amwa-doc.org/an-overlooked-condition-addressing-endometriosis-disparities-in-healthcare/

  Healthcare Inequities: Women from marginalized communities often face barriers in accessing specialized gynecological care, leading to delays in diagnosis and treatment. […] Additionally, research indicates that complication risks are greater in surgical care related to endometriosis for Hispanic, Black or African American, Native Hawaiian or Pacific Islander, and American Indian or Alaska Native women (Orlando et al., 2022). […] Addressing these disparities requires a multifaceted approach that includes improving awareness, ensuring diverse representation in clinical research, and expanding access to care. […] Additionally, healthcare providers should undergo training to recognize and address implicit biases that contribute to disparities in endometriosis diagnosis and treatment (Orlando et al., 2022). […] Through systemic changes in healthcare education, policy, and clinical practice, we can move toward a more inclusive and effective approach to diagnosing and treating endometriosis, ensuring that endometriosis care is no longer a privilege but a fundamental right for all.

• #58 An Overlooked Condition: Addressing Endometriosis Disparities in Healthcare – American Medical Women’s Association

  https://www.amwa-doc.org/an-overlooked-condition-addressing-endometriosis-disparities-in-healthcare/

  Healthcare Inequities: Women from marginalized communities often face barriers in accessing specialized gynecological care, leading to delays in diagnosis and treatment. […] Additionally, research indicates that complication risks are greater in surgical care related to endometriosis for Hispanic, Black or African American, Native Hawaiian or Pacific Islander, and American Indian or Alaska Native women (Orlando et al., 2022). […] Addressing these disparities requires a multifaceted approach that includes improving awareness, ensuring diverse representation in clinical research, and expanding access to care. […] Additionally, healthcare providers should undergo training to recognize and address implicit biases that contribute to disparities in endometriosis diagnosis and treatment (Orlando et al., 2022). […] Through systemic changes in healthcare education, policy, and clinical practice, we can move toward a more inclusive and effective approach to diagnosing and treating endometriosis, ensuring that endometriosis care is no longer a privilege but a fundamental right for all.

• #59

  https://www.who.int/news-room/fact-sheets/detail/endometriosis

  Endometriosis affects roughly 10% (190 million) of reproductive age women and girls globally. […] Access to early diagnosis and effective treatment of endometriosis is important, but is limited in many settings, including in low- and middle-income countries. […] Endometriosis is a complex disease that affects many women globally from the onset of their first period (menarche) through menopause, regardless of ethnic origin or social status. […] In many countries, the general public and most front-line healthcare providers are not aware that distressing and life-altering pelvic pain is not normal, leading to a normalization and stigmatization of symptoms and significant diagnostic delay. […] Due to diagnostic delays, prompt access to available treatment methods, including non-steroidal analgesics (painkillers), oral contraceptives and progestin-based contraceptives is often not achieved. […] WHO is also collaborating with relevant stakeholders to facilitate and support the collection and analysis of country- and region-specific endometriosis prevalence data for decision making.

• #60 Global Burden of Endometriosis in 204 Countries and Territories from 1990 to 2019

  https://www.imrpress.com/journal/CEOG/49/10/10.31083/j.ceog4910235/htm

  Background: To our knowledge, no systematic update on the descriptive epidemiology of endometriosis and its trends has been published based on the Global Burden of Disease (GBD) datasets. To investigate the burden of endometriosis in 204 countries and territories from 1990 to 2019. […] From 1990 to 2019, the global incidence and DALYs of endometriosis increased by 10.37% and 16.36%, respectively. However, both the age-standardized incidence rate (ASIR) and age-standardized DALY rate of endometriosis showed downward trends (EAPC = –0.81 and –0.80, respectively). […] The global incidence and DALYs of endometriosis continued to increase during 1990–2019. However, the ASIR and age-standardized DALY rate have shown decreasing trends worldwide, with increasing trends detected only in Eastern Europe.

• #61 Global Burden of Endometriosis in 204 Countries and Territories from 1990 to 2019

  https://www.imrpress.com/journal/CEOG/49/10/10.31083/j.ceog4910235/htm

  Given the increase in the global population, the incidence and DALYs were found to increase during the study period, but the ASIR and age-standardized DALY rate showed decreasing trends worldwide, with increasing trends observed only in Eastern Europe. […] From 1990 to 2019, the global incidence and DALYs of endometriosis were found to increase, but the ASIR and age-standardized DALY rate showed decreasing trends worldwide. Increasing trends in these ASRs were only observed in Eastern Europe, which emphasizes the need for improving prevention and treatment strategies for endometriosis in these regions. […] To the best of our knowledge, the current study is the first to comprehensively analyze the burden of endometriosis from 1990 to 2019 at global, regional, and national levels and further explore the relationship between endometriosis burden estimates and SES.

• #62 Epidemiology of deep endometriosis – gynsurgery.org

  https://www.gynsurgery.org/endometriosis/epidemiology-of-endometriosis/

  Epidemiology of endometriosis is important to learn about the cause of endometriosis. […] Endometriosis epidemiology is important since the prevalence and severity of endometriosis might be linked to pollution and to our modern lifestyle, comprising food intake, chemical disruptors, postponement of the first pregnancy, and stress, as indicated by “a career women’s disease”. Most important is that understanding if and why prevalence and severity are increasing would permit prevention. […] We did know very little since endometriosis epidemiology studies are based upon hospital discharge records. Our review explains why these observations are biased and cannot be trusted. Moreover a distinction between subtle and typical and cystic and deep endometriosis was not made. […] All deep endometriosis surgeons strongly feel that the prevalence and the severity of deep endometriosis is increasing. In South Italy deep endometriosis is actually very frequent although very rare 20 years ago. To the best of our knowledge this are the best data available today.

• #63 Time for global health policy and research leaders to prioritize endometriosis | Nature Communications

  https://www.nature.com/articles/s41467-023-43913-9

  Endometriosis is an incurable, under-diagnosed, systemic inflammatory disease affecting millions world-wide. […] Global public health policies are urgently needed to promote awareness, implement multidisciplinary care, and fund research for aetiology, biomarker discovery, and effective therapies for symptoms associated with endometriosis. […] Endometriosis affects ~10% of persons with a uterus, commonly striking teens and persisting across the reproductive life span (and sometimes beyond), greatly impacting personal relationships, educational and employment opportunities, and quality of life. […] There remains no reliable non-invasive biomarker of any endometriosis subtype. […] As delayed or undiagnosed endometriosis leads to compromised health, promoting awareness, improving access to care, and implementing multidisciplinary care paradigms are urgently needed in global public health policies. […] Equally urgent and important are prioritizing and committing resources to support fundamental research and biomarker discovery to shorten the protracted time to diagnosis and provide effective, long-term therapies for this chronic and debilitating disorder to the benefit of millions world-wide.

• #64 Epidemiology, Pathophysiology, and Diagnosis of Endometriosis

  https://www.consultant360.com/podcasts/epidemiology-pathophysiology-and-diagnosis-endometriosis

  In part 2 of this 2-part episode, Dan Martin, MD, speaks about his team’s research titled „The Epidemiology of Endometriosis is Poorly Known as the Pathophysiology and Diagnosis are Unclear,” including the gaps in endometriosis research, why those gaps are so problematic, and the key takeaways from their research. […] According to the Endometriosis Foundation of America, endometriosis is one of the leading causes in infertility, and on average, there is a seven to 10-year delay in diagnosis. […] Well, without knowing which specific phenotypes of endometriosis have different biologic behaviors, we don’t really know how many types of endometriosis we need to study. […] Endometriosis is likely more than one disease, and we need more than one standardized definition and more than one or two standard treatments. Women need early proactive treatment and planning so that they can potentially limit the growth of endometriosis and avoid surgery.

• #65

  https://www.who.int/news-room/fact-sheets/detail/endometriosis

  Endometriosis affects roughly 10% (190 million) of reproductive age women and girls globally. […] Access to early diagnosis and effective treatment of endometriosis is important, but is limited in many settings, including in low- and middle-income countries. […] Endometriosis is a complex disease that affects many women globally from the onset of their first period (menarche) through menopause, regardless of ethnic origin or social status. […] In many countries, the general public and most front-line healthcare providers are not aware that distressing and life-altering pelvic pain is not normal, leading to a normalization and stigmatization of symptoms and significant diagnostic delay. […] Due to diagnostic delays, prompt access to available treatment methods, including non-steroidal analgesics (painkillers), oral contraceptives and progestin-based contraceptives is often not achieved. […] WHO is also collaborating with relevant stakeholders to facilitate and support the collection and analysis of country- and region-specific endometriosis prevalence data for decision making.

• #66 Endometriosis Care — Nuffield Department of Women’s & Reproductive Health

  https://www.wrh.ox.ac.uk/research/endometriosis-care

  Endometriosis causes severe pelvic pain and reduces fertility for millions of women worldwide. […] One of our key areas of research is to uncover the causes and subtypes of endometriosis through large-scale genetic and molecular epidemiological studies. Genetic (heritable) factors are known to play a role in endometriosis, and through collaborative studies involving thousands of women we have led global research identifying DNA variants in the genome that are associated with disease risk. […] Our research focuses on improving the understanding of endometriosis, working towards non-surgical methods of diagnosis and identifying better treatments.

• #67 Time for global health policy and research leaders to prioritize endometriosis | Nature Communications

  https://www.nature.com/articles/s41467-023-43913-9

  Endometriosis is an incurable, under-diagnosed, systemic inflammatory disease affecting millions world-wide. […] Global public health policies are urgently needed to promote awareness, implement multidisciplinary care, and fund research for aetiology, biomarker discovery, and effective therapies for symptoms associated with endometriosis. […] Endometriosis affects ~10% of persons with a uterus, commonly striking teens and persisting across the reproductive life span (and sometimes beyond), greatly impacting personal relationships, educational and employment opportunities, and quality of life. […] There remains no reliable non-invasive biomarker of any endometriosis subtype. […] As delayed or undiagnosed endometriosis leads to compromised health, promoting awareness, improving access to care, and implementing multidisciplinary care paradigms are urgently needed in global public health policies. […] Equally urgent and important are prioritizing and committing resources to support fundamental research and biomarker discovery to shorten the protracted time to diagnosis and provide effective, long-term therapies for this chronic and debilitating disorder to the benefit of millions world-wide.

• #68 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis is characterized by the presence of active foci of the endometrium (glandular cells and stroma) or endometrial tissue (endometrioides; Gr. eides-similar) occurring outside its cavity, that is, in the muscular layer of the uterus, other genitals and their surroundings, and even in places distant from the genital organs of the body. […] Endometriosis is a common gynecological disease in Poland and in the world. This disease affects from 10 to 15% of women of reproductive age and 35 to 50% of women with pelvic pain and/or infertility. […] The vast majority of cases of endometriosis occur in women between menarche and menopause. The peak of the disease falls in the period between 25 and 45 years of age. […] Literature data indicate that endometriosis is found in 0.15 to 3% of women operated on laparoscopically or by laparotomy, of which 12 to 32% are women after diagnostic laparoscopy due to pelvic pain delays and 10 to 60% of the patient after diagnostic laparoscopy due to disability.

• #69 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #70 Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8508982/

  Endometriosis in 7% of women is associated with their genetic predisposition in the family. […] The risk of developing endometriosis is the lowest in black women, the highest in Asian women. Caucasian women have a higher risk of getting sick than black women. […] Endometriosis is a problem of enormous importance not only from the medical and social angles but also from an economic point of view. The annual costs of endometriosis treatment in Europe range from 0.8 billion to 12.5 billion depending on the country and are comparable to other chronic diseases such as diabetes. […] Endometriosis has a significant negative impact on aspects of social life, family, and sexual, educational and professional life.

• #71 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Endometriosis affects 10-15% of all women of reproductive age and 70% of women with chronic pelvic pain. […] Unfortunately, for many of these women there is often a delay in diagnosis of endometriosis resulting in unnecessary suffering and reduced quality of life. […] Despite recent advances in identifying risk factors for endometriosis, the field continues to be limited by requiring surgical diagnosis of the disease, often done laparoscopically to confirm affected cases and appropriate controls. […] Ultimately, the establishment of a defined set of endometriosis risk factors could lead to the identification of a group of women and girls with a high enough risk profile to warrant screening. […] Despite the range of blood tests that have been evaluated, a reliable test has yet to be identified for the diagnosis of endometriosis.

• #72 Endometriosis: Epidemiology, Diagnosis and Clinical Management

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5737931/

  Endometriosis affects 10-15% of all women of reproductive age and 70% of women with chronic pelvic pain. […] Unfortunately, for many of these women there is often a delay in diagnosis of endometriosis resulting in unnecessary suffering and reduced quality of life. […] Despite recent advances in identifying risk factors for endometriosis, the field continues to be limited by requiring surgical diagnosis of the disease, often done laparoscopically to confirm affected cases and appropriate controls. […] Ultimately, the establishment of a defined set of endometriosis risk factors could lead to the identification of a group of women and girls with a high enough risk profile to warrant screening. […] Despite the range of blood tests that have been evaluated, a reliable test has yet to be identified for the diagnosis of endometriosis.

• #73 The epidemiology of endometriosis is poorly known as the pathophysiology and diagnosis are unclear

  https://lirias.kuleuven.be/3274100

  The epidemiology of endometriosis is poorly known as the pathophysiology and diagnosis are unclear. […] Endometriosis has been considered to be a single disease defined as 'endometrium like glands and stroma outside the uterus’. […] All large datasets, especially those based on hospital discharge records, consider endometriosis to be a single disease without taking into account severity. […] In particular, the variable prevalence and recognition of subtle lesions is problematic. […] Whether the prevalence is increasing, or whether endometriosis is associated with fat intake or an increased risk of cardiovascular disease is unclear.

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