Materiały źródłowe

• #1

  https://link.springer.com/article/10.1007/s13668-024-00518-y

  Endometriosis (EM) is a chronic gynecological disease that affects about 10% of women worldwide. […] Because some disease-related processes, such as inflammation, hormonal activity, menstrual cycle, or prostaglandin metabolism, can be modified by diet, nutrition may have a significant impact on development and treatment of EM. […] The attention of researchers has so far concentrated mainly on the role of nutrition in the risk of developing EM, while less attention has been paid to examining the use of diet in the treatment of the disease. […] Current studies focus primarily on various dietary components that have antiproliferative, anti-inflammatory, antioxidant, analgesic, and estrogen-lowering properties. […] Exploring different ways of coping with endometriosis can make a significant contribution to improving the quality of life of women at risk or diagnosed with EM.

• #2 The Role of Nutrition in Endometriosis Prevention and Management: A Comprehensive Review

  https://www.ijfs.ir/article_721837.html

  Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, leading to debilitating symptoms and significant impacts on quality of life. […] This comprehensive review explores the complex interplay between various food substances and endometriosis, summarizing the latest research findings on both exacerbating and protective dietary factors. Key exacerbating factors identified include alcohol, red meat, processed foods high in saturated and trans fats, and excessive caffeine intake, all of which have been associated with increased inflammation and hormonal imbalance implicated in endometriosis progression. Conversely, antioxidants, B-complex vitamins, vitamin D, calcium, polyunsaturated fatty acids (omega-3 and omega-6), and dietary fiber have shown promise in exerting anti-inflammatory and protective effects against endometriosis. The review underscores the importance of promoting a balanced and nutritious diet rich in anti-inflammatory and antioxidant-rich foods while limiting the intake of pro-inflammatory substances for individuals with endometriosis.

• #3 New Understanding of Diagnosis, Treatment and Prevention of Endometriosis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9180566/

  For 100 years, pelvic endometriosis has been considered to originate from the implantation of endometrial cells following retrograde menstruation or metaplasia. […] This G-E concept also suggests prevention by decreasing oxidative stress from retrograde menstruation or the peritoneal microbiome. This suggests the prevention of vaginal infections and changes in the gastrointestinal microbiota through food intake and exercise. […] Although still unproven, it is logical to assume that decreasing oxidative stress by preventing retrograde menstruation or changing the peritoneal and upper genital tract microbiome will decrease the risk of initiating endometriosis. Both can be achieved with continuous oral contraception or progestogens, decreasing menstruation and the risk of ascending infections. Moreover, vaginal infections merit more attention.

• #4

  https://www.who.int/news-room/fact-sheets/detail/endometriosis

  At present, there is no known way to prevent endometriosis. […] Enhanced awareness, followed by early diagnosis and management may slow or halt the natural progression of the disease and reduce the long-term burden of its symptoms, including possibly the risk of central nervous system pain sensitization. […] WHO aims to stimulate and support the adoption of effective policies and interventions to address endometriosis globally, especially in low and middle-income countries. […] WHO is partnering with multiple stakeholders, including academic institutions, non-state actors and other organizations that are actively involved in research to identify effective models of endometriosis prevention, diagnosis, treatment, and care.

• #5 Endometriosis Potential Triggers and Prevention

  https://itsabouttime.me/blog/endometriosis-causes-potential-triggers-and-prevention/

  Currently, it is not possible to prevent endometriosis because the exact causes of the condition are not fully understood. Without knowing the precise mechanisms that lead to its development, effective preventive measures haven’t yet been discovered. […] However, ongoing research offers hope for the future. Especially as our understanding of the causes of endometriosis improves, there’s potential for medical breakthroughs that could enable targeted preventive strategies.

• #6 Explaining endometriosis: What parents should know

  https://answers.childrenshospital.org/endometriosis/

  When talking about potential prevention, Dr. Shim urges parents to encourage an open dialogue about period and pelvic pain. Severe and debilitating pain is never normal for people who get periods, so it is important to listen to these concerns when your child brings them up. […] Unfortunately, endometriosis is a chronic condition, but many patients experience great outcomes with the available treatment plans. Parents and teens should check in with their provider to ask about what treatment options work best for them and to get on the road to leading a healthy and comfortable life.

• #7 Case–control study to develop and validate a questionnaire for the secondary prevention of endometriosis | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230828

  Endometriosis is a debilitating gynecologic disease characterized by the implantation of endometrial tissue in ectopic locations, with signs of severe and chronic inflammation. The new knowledge on endometriosis has highlighted the value of secondary prevention through the early diagnosis and treatment of lesions to reduce serious consequences, first of all, infertility and chronic pelvic pain. […] The purpose of this study is to validate a simple and effective questionnaire to precociously identify women with endometriosis, leading them to the correct diagnostic approach and the most appropriate treatment. […] This study has analyzed the results of a questionnaire which aimed to identify patients at high risk for endometriosis, through the association with risk factors and symptomatology. Its purpose was to shape up a prediction model that could identify women with suspected endometriosis to lead them to correct diagnostic procedures and rapid diagnosis. […] In conclusion, we believe that our questionnaire could provide a powerful tool for the secondary prevention of endometriosis.

• #8 What Is Endometriosis? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/endometriosis/guide/

  Since its not clear what exactly causes endometriosis, theres currently no way to prevent it. High estrogen levels, however, have been consistently associated with endometriosis, and research shows that estrogen stimulates the growth of endometriotic tissue. Lowering the estrogen levels in your body may help reduce the severity of symptoms. To keep circulating estrogen levels lower, the U.S. Department of Health and Human Services Office on Womens Health suggests the following: […] Consider using hormonal birth control such as pills, patches, or rings with lower doses of estrogen. […] Exercise more than four hours a week. Regular exercise and a lower amount of body fat help decrease the amount of estrogen circulating through the body. […] Alcohol raises estrogen levels, so limit yourself to no more than one drink per day […] Limit caffeine, as research suggests that, for some people, there may be an inverse relationship between caffeine intake and estrogen levels, which can become an issue as caffeine intake increases to higher levels.

• #9 Endometriosis

  https://womenshealth.gov/a-z-topics/endometriosis

  You can’t prevent endometriosis. But you can reduce your chances of developing it by lowering the levels of the hormone estrogen in your body. Estrogen helps to thicken the lining of your uterus during your menstrual cycle. […] To keep lower estrogen levels in your body, you can: […] Talk to your doctor about hormonal birth control methods, such as pills, patches or rings with lower doses of estrogen. […] Exercise regularly (more than 4 hours a week). This will also help you keep a low percentage of body fat. Regular exercise and a lower amount of body fat help decrease the amount of estrogen circulating through the body. […] Avoid large amounts of alcohol. Alcohol raises estrogen levels. No more than one drink per day is recommended for women who choose to drink alcohol. […] Avoid large amount of drinks with caffeine. Studies show that drinking more than one caffeinated drink a day, especially sodas and green tea, can raise estrogen levels.

• #10 Endometriosis: Can It Be Prevented?

  https://www.webmd.com/women/endometriosis/can-i-prevent-endometriosis

  Although theres no way to totally prevent endometriosis, you may be able to lower your chances of getting the condition and to manage your symptoms if you do get it. […] Your doctor can prescribe hormones that can lower your estrogen levels. These include birth control pills, patches, or vaginal rings with low doses of estrogen. […] Working out is great for your whole body. And if you make it a habit to do at least 30 minutes of aerobic exercise four to five times a week, it could lower your chances of getting endometriosis. […] Studies have shown that drinking too much alcohol can raise the amount of estrogen your body makes, which could lead to endometriosis. If youre a woman who drinks, stick to no more than one alcoholic drink per day.

• #11 Endometriosis Prevention | Prevention of Endometriosis

  https://www.patientsengage.com/conditions/endometriosis/prevention?page=1

  You can’t prevent endometriosis. But you can work towards reducing your chances of developing it by lowering the levels of the hormone estrogen in your body. Estrogen helps to thicken the lining of your uterus during your menstrual cycle. […] To keep lower estrogen levels in your body, you can: Talk to your doctor about hormonal birth control methods, such as pills, patches or rings with lower doses of estrogen. Exercise regularly (more than 4 hours a week). Avoid large amounts of alcohol. Alcohol raises estrogen levels. Avoid large amount of drinks with caffeine. Drinking more than one caffeinated drink a day can raise estrogen levels. […] You can manage your endometriosis by lowering the levels of the hormone estrogen in your body. Estrogen helps to thicken the lining of your uterus during your menstrual cycle. To keep lower estrogen levels in your body, you can: Exercise regularly (more than 4 hours a week). This will also help you lower body fat which helps decrease the amount of estrogen circulating through the body. Avoid large amounts of alcohol. Alcohol raises estrogen levels.

• #12 Endometriosis – Types, Symptoms, Causes and treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Number for

  https://www.pacehospital.com/endometriosis-types-symptoms-risk-factors-causes-and-complications

  Avoid large amounts of caffeine: Some studies showed that drinking more than one caffeinated drink daily, particularly sodas and green tea, may raise oestrogen levels. […] Additionally, primary amenorrhea (failure of menses to occur by age 16 years), other dietary and lifestyle habits such as increased intake of omega-3 fatty acids, and other factors such as prolonged breastfeeding and tubal ligation are associated with a decreased risk for endometriosis.

• #13 Endometriosis Treatment & Management: Approach Considerations, Hormonal Therapy, Surgical Intervention

  https://emedicine.medscape.com/article/271899-treatment

  No current methods of prevention are known. Some evidence suggests that rapid and aggressive medical or surgical therapy can arrest progression, especially when the disease is caught in the early (minimal to mild) stages. […] Early and prolonged use of oral contraceptive pills, pregnancy, and breastfeeding seem to afford some degree of protection against this disease. […] A prospective cohort study by Farland et al that included 72,394 women who have had a pregnancy in the last 6 months, of which, 3,296 had endometriosis at follow-up, reported a 40% reduced risk of endometriosis for women who breastfed for 36 months or more throughout their reproductive lifetime compared with women who never breastfed (0.60, 0.50 to 0.72). The study also reported an 8% lower risk of endometriosis for every additional three months of total breastfeeding per pregnancy (hazard ratio 0.92, 95% confidence interval 0.90 to 0.94; P 0.001 for trend).

• #14 Endometriosis Medical Treatment – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/endometriosis/medical-treatment-for-endometriosis

  Continuous use is as easy as skipping the inactive pills in your pill pack or replacing your ring/patch as soon as it would normally be time to remove the old one. In doing so, you will decrease the number of bleeding days that you have and prevent pain associated with your period. […] Thus, suppressing (stopping) your period with the following hormonal medications can help relieve endometriosis-related pain and prevent endometriosis from developing or becoming worse over time. […] Continuous progestins are safe, effective and well-tolerated by most women. […] Each of these progestin-only methods can make your periods lighter and less frequent or stop them altogether. […] Continuous combined estrogen and progestin therapy is safe and well-tolerated by most women. […] Talk to your gynecologist to see whether or not continuous combined estrogen/progestin treatment is right for you.

• #15 Best Birth Control for Endometriosis Relief

  https://www.verywellhealth.com/hormonal-contraceptives-and-endometriosis-treatment-906491

  Hormonal contraceptives can reduce pain and other symptoms […] Hormonal birth control methods are an effective treatment for endometriosis symptoms. […] Continuous use of hormonal birth control i.e., without a break between dosing has been found to be most effective for endometriosis. […] These treatments stop the ovaries from producing key hormones, including estrogen, which can slow the growth of the uterine lining (endometrium) and prevent new lesions. […] Eliminating periods is helpful for women with endometriosis because symptoms tend to be worse during menstruation. […] The pill can help with endometriosis pain because it can make periods shorter or lighter or even eliminate them altogether. […] Continuous birth control pills like Seasonique may also offer an additional benefit: the elimination or reduction of periods and associated dysmenorrhea linked to endometriosis.

• #16 Best Birth Control for Endometriosis Relief

  https://www.verywellhealth.com/hormonal-contraceptives-and-endometriosis-treatment-906491

  The Mirena IUD is thought to help reduce the amount of blood flow during a woman’s period, which may help to reduce endometriosis-related pain. […] While they are not FDA-approved to treat endometriosis specifically, these IUDs are now FDA-approved to treat heavy periods for up to five years. […] The NuvaRing is a form of contraception that is worn inside the vagina for up to five weeks before needing to be replaced. […] Birth control patches are small adhesive stickers that deliver hormonal contraception through the skin. […] Depo Provera and Depo-subQ Provera 104 have been shown to reduce pain caused by endometriosis. […] Though it is not known precisely how the progestin (etonogestrel) in Nexplanon helps relieve the symptoms of endometriosis, it is thought to work by suppressing the growth of endometrial tissue, thus causing it to gradually diminish.

• #17 Endometriosis – A Possible Cause and Prevention | Chennai Gynecologist

  https://chennaigynecologist.com/endometriosis-a-possible-cause-and-prevention/

  Endometriosis – A Possible Cause and Prevention […] Treatment for endometriosis is determined based on overall health and medical history, symptoms, severity of the condition, tolerance and preference for pregnancy. There is no cure for endometriosis but can be effectively treated through lifestyle changes, medications, hormonal therapy or surgery. […] Diet – High amount of fat in red meat can make the body produce chemicals called prostaglandins, which may lead to excess oestrogen production that can in turn cause extra endometrial tissue to grow. Adding more fresh fruits and vegetables as the main portion of every meal can be helpful. […] Exercise – Exercise can help reduce oestrogen levels and prevent heavy periods to improve symptoms of endometriosis. Studies have shown that high-intensity exercises like running or biking can help overcome endometriosis.

• #18 New Understanding of Diagnosis, Treatment and Prevention of Endometriosis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9180566/

  Preliminary evidence suggests that food rich in antioxidant as omega3, Vit E, Vit C and citrus decrease the risk of endometriosis. It is too early to fully understand the effect of vitamins on inflammation and immune response in endometriosis and to prevent endometriosis initiation or growth through modifications of the intestinal microbiota with food intake and sports.

• #19 New Understanding of Diagnosis, Treatment and Prevention of Endometriosis

  https://www.mdpi.com/1660-4601/19/11/6725

  All women deserve the prevention of recurrences after surgery. Although still unproven, it is logical to assume that decreasing oxidative stress by preventing retrograde menstruation or changing the peritoneal and upper genital tract microbiome will decrease the risk of initiating endometriosis. Both can be achieved with continuous oral contraception or progestogens, decreasing menstruation and the risk of ascending infections. Moreover, vaginal infections merit more attention. […] Preliminary evidence suggests that food rich in antioxidant as omega3, Vit E, Vit C and citrus decrease the risk of endometriosis. It is too early to fully understand the effect of vitamins on inflammation and immune response in endometriosis and to prevent endometriosis initiation or growth through modifications of the intestinal microbiota with food intake and sports.

• #20 Endometriosis – A Possible Cause and Prevention | Chennai Gynecologist

  https://chennaigynecologist.com/endometriosis-a-possible-cause-and-prevention/

  Selfcare – Stress is known to make endometriosis worse and vice versa. Ways to manage stress through meditation or developing hobbies can help you ease symptoms. […] Hormonal therapy – Hormonal replacements are suggested to lower oestrogen levels in the body to create and stop periods that also helps lesions to bleed less and thus reduce inflammation, scarring, and cyst formation. […] Surgery – Excision of as much of the affected tissue as possible helps ease symptoms and can increase the chances of getting pregnant.

• #21 Nutrition in the prevention and treatment of endometriosis: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9983692/

  Endometriosis is characterized by the presence of endometrial tissues outside the uterine lining, typically on the external surface of the uterus, the ovaries, fallopian tubes, abdominal wall, or intestines. […] Nutritional interventions may be helpful in the prevention and treatment of endometriosis and associated pain. Reducing dietary fat and increasing dietary fiber have been shown to reduce circulating estrogen concentrations, suggesting a potential benefit for individuals with endometriosis, as it is an estrogen-dependent disease. […] Anti-inflammatory properties of plant-based diets may benefit women with endometriosis. […] Furthermore, consumption of vitamin D has been shown to reduce endometrial pain via increased antioxidant capacity and supplementation with vitamins C and E significantly reduced endometriosis symptoms, compared with placebo.

• #22 Nutrition in the prevention and treatment of endometriosis: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9983692/

  Evidence suggests that dietary factors have important effects in both of these domains. Consumption of trans fats, palmitic acid, and red meat is associated with increased risk of endometriosis, while factors in plant-based foods, particularly fiber and antioxidants, and vitamin D may have helpful effects for prevention and treatment.

• #23 Endometriosis: Causes, Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/10857-endometriosis

  Endometriosis isnt a condition you can prevent. But certain factors can reduce your risk of developing the condition. […] Endometriosis seems to occur less likely in people who: […] Have been pregnant more than once. […] Breastfeed.

• #24 Endometriosis Prevention – WelcomeCure

  https://www.welcomecure.com/diseases/endometriosis/prevention

  Vaginal childbirth prevents recurrence of Endometriosis as compared to Caesarean section. […] Do not delay pregnancy for a long time. Endometriosis is more prevalent in women who have never given birth. […] Avoid sedentary life. Routine exercises prevent hormonal imbalances.

• #25 Discoveries in Medicine – Ending Endometriosis Prior to Conception

  https://discoveries.vanderbilthealth.com/2023/05/ending-endometriosis-prior-to-conception/

  Pregnant Woman on bus May 03, 2023 A suite of studies supports a shift from reactivity to pre-pregnancy prevention of painful condition. […] Medical studies in mice at Vanderbilt University Medical Center may soon prompt a major shift in the traditional clinical approach to endometriosis, after their results suggest that prevention of this common disease may be the most viable option. […] Nobody is looking at prevention; thats a new frontier for endometriosis. […] Until recently, reactivity to the condition has been the focus for most physicians, Osteen says. […] Instead, were trying to prevent the disease. […] A major finding is that a fathers toxicant exposure can be transmitted to his daughter at conception. Fortunately, that is among the type of cases that may be preventable.

• #26 The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model | Scientific Reports

  https://www.nature.com/articles/s41598-021-86586-4

  Rutin induces apoptosis and has antioxidant activity that can be profitable in the treatment of the Endo and it is used as a novel agent. […] Rutin (quercetin-3-rhamnosyl-glucoside) is a flavonol that is significantly found in some fruits and vegetables. […] Different agents are used for the prevention, the management and the treatment of Endo. […] The results showed that rutin induces early apoptosis by the expression of Bcl-2, Bax and caspase and TUNEL staining confirmed the results. It also showed antioxidant properties that decreases Endo. It can be stated that rutin (especially 6000 g/kg) improves Endo by apoptosis and antioxidant mechanisms.

• #27 Prevention of Endometriosis: Is It Possible? | SpringerLink

  https://link.springer.com/chapter/10.1007/978-3-030-97236-3_27

  This chapter discusses primary, secondary, and tertiary prevention in general as well as data on existing options for prevention of endometriosis. […] Due to unclear etiology of endometriosis and unclear data on possibly modifiable influencing factors such as nutrition, neither causal therapy nor primary prevention are possible yet. Secondary prevention can be achieved by promoting awareness of the disease in the general population and health care professionals as well as specific diagnostic workup including especially a dedicated ultrasonographic exam. Tertiary prevention is achievable by use of postoperative hormonal treatment and complete surgical excision of lesions.

• #28 Endometriosis Prevention | Prevention of Endometriosis

  https://www.patientsengage.com/conditions/endometriosis/prevention

  You can’t prevent endometriosis. But you can work towards reducing your chances of developing it by lowering the levels of the hormone estrogen in your body. Estrogen helps to thicken the lining of your uterus during your menstrual cycle. […] To keep lower estrogen levels in your body, you can: Talk to your doctor about hormonal birth control methods, such as pills, patches or rings with lower doses of estrogen. Exercise regularly (more than 4 hours a week). Avoid large amounts of alcohol. Alcohol raises estrogen levels. Avoid large amount of drinks with caffeine. Drinking more than one caffeinated drink a day can raise estrogen levels.

• #29 endometriosis: symptoms, treatment, prevention – Institut Pasteur

  https://www.pasteur.fr/en/medical-center/disease-sheets/endometriosis

  There is no effective preventive treatment for endometriosis. Raising awareness of the condition can facilitate diagnosis and avoid symptom normalization. Early diagnosis and regular monitoring can help reduce symptoms over the long term.

• #30 Healio: Q&A | New Stroke Guidance Highlights Risk for Women with Endometriosis, Early Menopause

  https://www.cedars-sinai.org/newsroom/healio-qa–new-stroke-guidance-highlights-risk-for-women-with-endometriosis-early-menopause/

  Newly updated guidelines from the American Heart Association and the American Stroke Association found some groups of women are at greater risk of stroke: those who have endometriosis […] The American Heart Association recommends lowering stroke risk by eating a healthy diet; prioritizing exercise and adequate sleep; maintaining a healthy weight; not smoking; and ensuring appropriate blood pressure, cholesterol and glucose targets are met.

• #31 Prior Endometriosis Diagnoses May Increase Ovarian Cancer Risk

  https://www.cancernetwork.com/view/prior-endometriosis-diagnoses-may-increase-ovarian-cancer-risk

  Patients with prior endometriosis may benefit from ovarian cancer risk and prevention counseling and could be integral for future prevention studies. […] Additionally, patients with prior endometriosis diagnoses may benefit from ovarian cancer risk and prevention counseling and targeted screening; this population could be integral to evaluate in future prevention studies. […] Studies that can better characterize the biology underlying these associations are urgently needed to guide improved ovarian cancer screening and prevention strategies among patients with severe endometriosis, with or without other important ovarian cancer risk factors.

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