Wyprysk dyshidrotyczny
Leczenie
Wyprysk dyshidrotyczny (pompholyx) to przewlekła, nawracająca dermatoza zapalna, manifestująca się intensywnie swędzącymi, drobnymi pęcherzykami na dłoniach i/lub stopach, najczęściej u nastolatków i młodych dorosłych. Podstawą terapii jest codzienne stosowanie emolientów bogatych w ceramidy, które zapobiegają wysuszeniu i wspomagają odbudowę bariery skórnej, oraz miejscowe kortykosteroidy o dużej lub bardzo dużej sile działania aplikowane przez 2-4 tygodnie, często po mokrych okładach dla zwiększenia penetracji. W przypadku sączących zmian zaleca się kąpiele w roztworze nadmanganianu potasu (1:10 000) przez 10-15 minut, 1-2 razy dziennie do 5 dni, okłady z roztworu Burowa (1:40) oraz zimne kompresy. Drenaż dużych pęcherzyków powinien być wykonywany aseptycznie przez lekarza. Leki przeciwhistaminowe (difenhydramina, loratadyna) mogą łagodzić świąd i poprawiać sen, choć nie wpływają na zmiany skórne.
- Wprowadzenie do wyprysku dyshidrotycznego
- Leczenie pierwszego rzutu
- Leczenie zaawansowane
- Inhibitory kalcyneuryny
- Kortykosteroidy systemowe
- Fototerapia
- Alitretynoina
- Leki immunosupresyjne
- Leki biologiczne
- Metody dodatkowe
- Postępowanie przy alergiach
- Zapobieganie zaostrzeniom
- Leczenie w medycynie alternatywnej
- Podsumowanie kliniczne
Wprowadzenie do wyprysku dyshidrotycznego
Wyprysk dyshidrotyczny (pompholyx) to przewlekła nawracająca dermatoza zapalna, charakteryzująca się występowaniem intensywnie swędzących, małych pęcherzyków na dłoniach i/lub stopach. Ta specyficzna odmiana wyprysku dotyka najczęściej nastolatków i młodych dorosłych, a jej przebieg może być od łagodnego i samoograniczającego się do przewlekłego i ciężkiego.12 Dolegliwość jest również znana pod nazwami: dyshidrotic eczema, dyshidrosis lub wyprysk rąk i stóp. Mimo że choroba może ustąpić samoistnie, właściwe leczenie pomaga kontrolować objawy i zapobiegać nawrotom.3
Leczenie pierwszego rzutu
Leczenie wyprysku dyshidrotycznego jest ukierunkowane na kontrolę objawów i zapobieganie nawrotom. Terapia pierwszej linii obejmuje kilka podstawowych metod, których dobór zależy od nasilenia objawów.45
Emolienty i nawilżanie
Podstawą leczenia wyprysku dyshidrotycznego jest regularne stosowanie emolientów (medycznych preparatów nawilżających), które są uznawane za terapię pierwszej linii.6 Emolienty należy stosować codziennie w celu zapobiegania wysuszeniu skóry oraz jako substytut mydła podczas mycia. Zapobiega to odtłuszczeniu skóry, które może działać drażniąco.65 Zaleca się:
- Stosowanie emolientów bezpośrednio po każdej kąpieli, prysznicu i myciu rąk7
- Wybieranie preparatów bogatych w ceramidy, aby wspomóc odbudowę bariery skórnej78
- Używanie preparatów hipoalergicznych, bez dodatku alkoholu i substancji zapachowych9
Miejscowe kortykosteroidy
Miejscowe kortykosteroidy są podstawowym elementem leczenia wyprysku dyshidrotycznego i pozwalają na redukcję stanu zapalnego oraz gojenie pęknięć skóry.64 Zwykle stosuje się:
- Preparaty o dużej lub bardzo dużej sile działania, szczególnie w początkowej fazie terapii10
- Maści, które lepiej penetrują skórę niż kremy (choć pacjenci mogą preferować kremy w ciągu dnia)10
- Aplikację po wcześniejszym zastosowaniu mokrych okładów lub kompresów, co zwiększa wchłanianie leku1112
Kortykosteroidy powinny być stosowane przez ograniczony czas (zazwyczaj 2-4 tygodnie), aby zminimalizować ryzyko działań niepożądanych, takich jak ścieńczenie skóry.1314
Kąpiele i okłady
W przypadku sączących się zmian i aktywnych pęcherzyków zaleca się:
- Kąpiele w roztworze nadmanganianu potasu (1:10.000) przez 10-15 minut, 1-2 razy dziennie przez maksymalnie 5 dni156
- Okłady z roztworu octanu glinu (roztwór Burowa) w rozcieńczeniu 1:40, stosowane do czasu wyschnięcia pęcherzyków16
- Zimne kompresy, stosowane 2-4 razy dziennie przez 15 minut, co pomaga osuszyć pęcherzyki i zmniejszyć świąd1117
Drenaż dużych pęcherzyków może być wykonany za pomocą sterylnej strzykawki, przy czym pozostawia się nienaruszony „dach” pęcherzyka.1618 Czynność tę powinien wykonywać lekarz, nie pacjent.19
Leki przeciwhistaminowe
Doustne leki przeciwhistaminowe mogą być pomocne w łagodzeniu świądu i poprawie snu, jeśli świąd zakłóca odpoczynek nocny.1315 Dostępne są preparaty bez recepty, takie jak:
Należy pamiętać, że leki przeciwhistaminowe nie wpływają bezpośrednio na same zmiany skórne, ale mogą zmniejszyć drapanie, co pomaga w gojeniu.20
Leczenie zaawansowane
W przypadku wyprysku dyshidrotycznego opornego na leczenie pierwszego rzutu lub o ciężkim przebiegu, stosuje się bardziej zaawansowane metody terapeutyczne.215
Inhibitory kalcyneuryny
Miejscowe inhibitory kalcyneuryny (takrolimus, pimekrolimus) stanowią alternatywę dla kortykosteroidów, szczególnie w terapii długoterminowej, gdyż nie powodują ścieńczenia skóry.1022 Zalety stosowania tych preparatów obejmują:
- Brak działań niepożądanych typowych dla sterydów14
- Możliwość stosowania na wrażliwe obszary skóry23
- Udowodnioną skuteczność w leczeniu przewlekłego wyprysku rąk10
Preparaty te nie powinny być łączone z terapią światłem UV.24
Kortykosteroidy systemowe
W przypadku bardzo ciężkich zaostrzeń wyprysku dyshidrotycznego może być zalecana krótkotrwała terapia doustnymi preparatami kortykosteroidowymi.2110 Stosuje się:
- Prednizon w dawce 0,5-1,0 mg/kg/dobę, stopniowo zmniejszanej przez 2 tygodnie25
- Domięśniowe podanie zawiesiny triamcynolonu10
Leczenie systemowe kortykosteroidami powinno być stosowane krótkotrwale i pod ścisłą kontrolą lekarską ze względu na ryzyko działań niepożądanych.2026
Fototerapia
Fototerapia jest skuteczną metodą leczenia uporczywego wyprysku dyshidrotycznego.2127 Dostępne opcje obejmują:
- PUVA (psoralen + UVA) – najskuteczniejsza metoda fototerapii w przypadku przewlekłego wyprysku rąk i stóp25
- Bath-PUVA – miejscowe stosowanie 8-metoksypsoralenu połączone z naświetlaniem UVA28
- Wąskopasmowe promieniowanie UVB25
- UVA-129
Fototerapia wymaga specjalistycznego sprzętu i jest zwykle przeprowadzana w warunkach szpitalnych lub ambulatoryjnych.21
Alitretynoina
Alitretynoina (9-cis kwas retinowy) jest doustnym retinoidem, który został zatwierdzony do leczenia ciężkich przypadków przewlekłego wyprysku rąk, w tym wyprysku dyshidrotycznego, które nie odpowiedziały na leczenie miejscowymi silnymi kortykosteroidami.2130 Preparat działa poprzez aktywację receptora retinoidowego X i wszystkich receptorów retinowych.30 Ze względu na potencjalne działanie teratogenne, u kobiet w wieku rozrodczym konieczne jest stosowanie skutecznej antykoncepcji.31
Leki immunosupresyjne
W ciężkich, opornych na leczenie przypadkach wyprysku dyshidrotycznego mogą być stosowane leki immunosupresyjne:2930
- Metotreksat – wykazano skuteczność niskich dawek metotreksatu w leczeniu opornego wyprysku dłoni i stóp32
- Azatiopryna22
- Mykofenolan mofetylu30
- Cyklosporyna33
Leki te stosuje się pod ścisłą kontrolą specjalisty ze względu na potencjalne działania niepożądane.33
Leki biologiczne
Najnowsze badania nad wypryskem dyshidrotycznym doprowadziły do opracowania nowych opcji terapeutycznych, w tym leków biologicznych:34
- Dupilumab (Dupixent) – przeciwciało monoklonalne blokujące szlak IL-4/IL-13, skuteczne w przypadkach opornych na standardowe leczenie3536
- Inhibitory JAK (Janus kinazy) – takie jak upadacytynib (Rinvoq) i baricytynib (Olumiant)2837
Terapie te są szczególnie obiecujące dla pacjentów, u których inne metody leczenia nie przyniosły poprawy.34
Metody dodatkowe
Iniekcje toksyny botulinowej
Śródskórne iniekcje toksyny botulinowej (Botox) mogą być stosowane u pacjentów z wypryskem dyshidrotycznym, szczególnie gdy towarzyszy mu nadmierna potliwość (hyperhidrosis).2927 Metoda ta:
- Zmniejsza nadmierną potliwość, która może być czynnikiem wyzwalającym wyprysk14
- Może przynieść znaczącą poprawę w przypadkach opornych na konwencjonalne terapie38
- Jest szczególnie przydatna jako leczenie wspomagające w formach dyshidrotycznych25
Jonoforeza
Jonoforeza z użyciem wody wodociągowej może być stosowana jako dodatkowa metoda leczenia wyprysku dyshidrotycznego, szczególnie gdy towarzyszy mu nadmierna potliwość.39 Badania wykazały, że:
- 17 na 20 pacjentów w badaniu z zastosowaniem jednostronnej jonoforezy wykazało poprawę objawów wyprysku dyshidrotycznego39
- Czas remisji po zastosowaniu jonoforezy w połączeniu z miejscowymi kortykosteroidami był znacznie dłuższy (24,8 tygodnia) w porównaniu do samych kortykosteroidów (8,35 tygodnia)39
Jonoforeza może być stosowana zarówno jako samodzielna metoda, jak i jako uzupełnienie leczenia kortykosteroidami.39
Leczenie infekcji towarzyszących
Drapanie zmian skórnych w przebiegu wyprysku dyshidrotycznego może prowadzić do wtórnych infekcji.40 W przypadku podejrzenia infekcji stosuje się:
- Antybiotyki ogólnoustrojowe, które pokrywają spektrum działania przeciwko Staphylococcus aureus i paciorkowcom grupy A16
- Miejscowe preparaty antybakteryjne11
- W przypadku towarzyszącej infekcji grzybiczej – leki przeciwgrzybicze27
Objawy sugerujące infekcję to: żółte strupki, nasilenie bólu, obrzęk i zaczerwienienie.41
Postępowanie przy alergiach
Testy alergiczne
Jeśli podejrzewa się, że wyprysk dyshidrotyczny jest związany z alergią, dermatolog może zalecić przeprowadzenie testów płatkowych.4243 Testy te polegają na nałożeniu na skórę (najczęściej na plecach) małych ilości substancji potencjalnie alergizujących i obserwacji reakcji skórnych.42 Szczególną uwagę zwraca się na alergie na nikiel i kobalt, które często są związane z wypryskem dyshidrotycznym.43
Modyfikacje diety
W przypadku potwierdzenia nadwrażliwości na nikiel lub kobalt, lekarz może zalecić zmiany w diecie:4344
- Dieta niskonieklowa – eliminacja lub ograniczenie pokarmów bogatych w nikiel28
- Ograniczenie spożycia produktów zawierających kobalt45
W niektórych przypadkach stosuje się chelatory niklu (np. disulfiram) u pacjentów z nadwrażliwością na nikiel, którzy wykazują pozytywny wynik testu prowokacji doustnej.30
Zapobieganie zaostrzeniom
Odpowiednie postępowanie profilaktyczne może pomóc w zapobieganiu nawrotom wyprysku dyshidrotycznego.7
Unikanie czynników wyzwalających
Identyfikacja i unikanie czynników wyzwalających stanowi podstawę profilaktyki wyprysku dyshidrotycznego:286
- Ograniczenie kontaktu z wodą i drażniącymi substancjami chemicznymi46
- Noszenie rękawiczek ochronnych (najlepiej bawełnianych) podczas prac domowych745
- Zdejmowanie biżuterii podczas mycia rąk, aby zapobiec zaleganiu wody i mydła pod nią7
- Dokładne osuszanie rąk i stóp po kąpieli lub pływaniu7
Właściwa pielęgnacja skóry
Regularna i odpowiednia pielęgnacja skóry może zapobiec zaostrzeniom wyprysku dyshidrotycznego:9
- Mycie rąk i stóp letnią (nie gorącą) wodą z łagodnym, bezzapachowym mydłem4547
- Delikatne osuszanie skóry po umyciu (bez pocierania)9
- Regularne stosowanie emolientów, szczególnie po każdym myciu rąk9
- Utrzymywanie krótkich paznokci, aby uniknąć zadrapań podczas drapania48
Radzenie sobie ze stresem
Stres jest znanym czynnikiem wyzwalającym zaostrzenia wyprysku dyshidrotycznego.44 Metody redukcji stresu obejmują:
- Techniki relaksacyjne, takie jak medytacja i mindfulness49
- Regularna aktywność fizyczna41
- Biofeedback29
- Konsultacje z psychologiem w celu nauki technik radzenia sobie ze stresem28
Leczenie w medycynie alternatywnej
Oprócz konwencjonalnych metod terapeutycznych, niektórzy pacjenci poszukują alternatywnych podejść do leczenia wyprysku dyshidrotycznego.50
Medycyna tradycyjna chińska
Tradycyjna medycyna chińska (TCM) oferuje holistyczne podejście do leczenia wyprysku dyshidrotycznego:5152
- Ziołowe naparki stosowane zarówno wewnętrznie, jak i zewnętrznie51
- Moczenie dłoni i stóp w specjalnych roztworach ziołowych52
- Akupunktura, choć jest rzadziej stosowana niż preparaty ziołowe51
Zwolennicy tej metody podkreślają, że leczenie TCM ma na celu nie tylko złagodzenie objawów, ale także przywrócenie równowagi w organizmie.53
Probiotyki i modyfikacje diety
Niektóre badania i doświadczenia pacjentów sugerują potencjalną skuteczność probiotyków i modyfikacji diety w leczeniu wyprysku dyshidrotycznego:544
- Stosowanie silnych probiotyków dwa razy dziennie55
- Eliminacja z diety pszenicy, rafinowanych cukrów i alkoholu54
- Przejście na dietę niskowęglowodanową opierającą się na nieprzetworzonej żywności54
Należy jednak podkreślić, że skuteczność tych metod nie została w pełni potwierdzona w badaniach klinicznych.55
Podsumowanie kliniczne
Wyprysk dyshidrotyczny (pompholyx) jest przewlekłą dermatozą, która wymaga kompleksowego podejścia terapeutycznego. Leczenie pierwszego rzutu obejmuje emolienty, miejscowe kortykosteroidy, kąpiele w nadmanganianie potasu i leki przeciwhistaminowe. W przypadkach opornych na standardową terapię lub o ciężkim przebiegu, stosuje się leczenie zaawansowane: inhibitory kalcyneuryny, kortykosteroidy systemowe, fototerapię, alitretynoinę, leki immunosupresyjne i biologiczne.38
Kluczowe znaczenie ma również profilaktyka, obejmująca unikanie czynników wyzwalających, właściwą pielęgnację skóry i techniki radzenia sobie ze stresem. W niektórych przypadkach pomocne mogą być dodatkowe metody, jak iniekcje toksyny botulinowej czy jonoforeza.28
Należy pamiętać, że wyprysk dyshidrotyczny jest schorzeniem przewlekłym, z tendencją do nawrotów. Optymalne wyniki terapeutyczne można osiągnąć poprzez kombinację różnych metod leczniczych, dostosowanych do indywidualnych potrzeb pacjenta i pod ścisłą kontrolą dermatologa.3856
Kolejne rozdziały
Zapraszamy do dalszego czytania naszego leksykonu.
Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.
Materiały źródłowe
- #1 Dyshidrosis – Wikipediahttps://en.wikipedia.org/wiki/Dyshidrosis
Avoiding triggers may be useful, as may be the application of a barrier cream or wearing of gloves. Treatment is generally made with steroid cream, although this can be dangerous in the long term due to the side effect of thinning of the skin, which is particularly troublesome in the context of hand dyshidrosis due to the amount of toxins and bacteria the hands typically come in contact with. High strength steroid creams may be required for the first week or two. […] In especially acute and severe cases, systemic steroids can be taken orally; the immunosuppressive drug tacrolimus, or PUVA therapy may also be tried. Dapsone (diamino-diphenyl sulfone), an antibacterial, has been recommended for the treatment of dyshidrosis in some chronic cases. […] Antihistamines such as Fexofenadine may be used to help with the itching. Potassium permanganate dilute solution soaks are popular, used to „dry out” the vesicles and kill off superficial Staphylococcus aureus, but they can be very painful and undiluted may cause significant burning. […] Alitretinoin (9-cis-retinoic acid) has been approved for prescription in the UK. It is specifically used for chronic hand and foot eczema.
- #2 Dyshidrotic dermatitis – Symptoms, diagnosis and treatment | BMJ Best Practicehttps://bestpractice.bmj.com/topics/en-gb/91
Dyshidrotic dermatitis is a chronic, relapsing-remitting vesicular eruption of the palms and soles; classically pruritic; also known as dyshidrotic eczema dermatitis. […] The foremost objective in treatment is identification and avoidance of exacerbating factors. […] First-line therapy is topical corticosteroids or immunomodulators. […] For severe eruptive bullae on the palms and soles, which are consistent with pompholyx, a short-term course of oral corticosteroids may be helpful as a temporising measure. […] Other therapeutic options, if symptoms don’t respond to initial treatment, include phototherapy, oral immunomodulators, and nickel-directed therapy.
- #3 Pompholyx eczemahttps://sales-demo.adam.com/content.aspx?productid=582&pid=1&gid=000832&tab=labordelivery
Pompholyx may go away on its own. Treatment is aimed at controlling the symptoms, such as itching and preventing blisters. Your provider will likely recommend self-care measures. […] Keep your skin moist by lubricating or moisturizing the skin. Use ointments (such as petroleum jelly), creams, or lotions. […] Medicines that help relieve itching can be bought without a prescription. […] Your provider may prescribe topical medicines. These are ointments or creams that are applied to the skin. Types include: […] If symptoms are severe, you may need other treatments, such as: […] Pompholyx eczema usually goes away without problems, but symptoms may come back. Severe scratching may lead to thick, irritated skin. This is called lichenified skin. This makes the problem harder to treat.
- #4 Dyshidrotic Eczema (Pompholyx) Treatment & Management: Approach Considerations, Pharmacologic Therapy, Ultraviolet Light Therapyhttps://emedicine.medscape.com/article/1122527-treatment
Treatment of dyshidrotic eczema (pompholyx) can be quite challenging, both because of the severe inflammatory process that can be involved and because of the frequency of recurrences. The economic burden of this chronic eczema has been stressed. […] In dyshidrotic eczema, typical first-line treatment includes high-strength topical steroids and cold compresses. Corticosteroids are cornerstones of topical therapy. Short courses of oral steroids are the second line of treatment for acute flares, and other immunosuppressants have also been tried. Calcineurin inhibitors may also be effective. […] For recalcitrant cases, corticosteroids are combined with immunosuppressants. […] Intradermal injection of onabotulinumtoxinA has received interest as a treatment for this condition. Probiotics have been suggested as a potential treatment for eczema.
- #5 Pompholyx (dyshidrotic eczema)https://www.nhs.uk/conditions/pompholyx/
Pompholyx (also called dyshidrotic eczema) is a type of eczema that affects the hands or feet. It’s usually a long-term condition, but treatment can help control the symptoms. […] Treatment can help control the symptoms. […] The main treatments for pompholyx are: moisturisers (emollients) used every day to stop the skin becoming dry; steroid creams and ointments (topical steroids) used for a few weeks at a time to reduce irritation and soreness. […] If the blisters leak fluid, a GP may suggest soaking your skin in potassium permanganate solution. This helps dry the blisters and reduces the risk of them getting infected. […] If the blisters become infected, a GP may prescribe antibiotics. […] If your symptoms are severe or treatment is not helping, a GP may refer you to a skin specialist (dermatologist). […] A dermatologist may recommend other treatments, such as: steroid tablets; treatment with ultraviolet (UV) light; other medicines, such as alitretinoin.
- #6 Pompholyx (dyshidrotic) eczema – National Eczema Societyhttps://eczema.org/information-and-advice/types-of-eczema/pompholyx-eczema-2/
Pompholyx eczema needs to be treated with topical steroids to reduce inflammation and heal cracks. […] Any obvious trigger for the pompholyx flare should be avoided as far as possible, especially in the case of a contact allergy. […] Emollients (medical moisturisers) are a first-line treatment and should be used for moisturising and washing. […] If your skin is weeping, oozing and crusting, a potassium permanganate soak may be advised. […] Potassium permanganate soaks can be used once or twice a week. […] A leave-on emollient or an emollient soap substitute should be used for washing, since soap de-greases the skin and can also act as an irritant. […] Pompholyx eczema needs to be treated with topical steroids to reduce inflammation and heal cracks. […] For severe pompholyx eczema, a dermatology referral may be required for treatment and/or diagnosing contact allergy through patch testing.
- #7 Dyshidrotic Eczema: Symptoms, Causes, Treatment | National Eczema Associationhttps://nationaleczema.org/types-of-eczema/dyshidrotic-eczema/
Knowing your triggers and maintaining a regular skincare routine can help prevent and manage dyshidrotic eczema flares. […] Helpful skincare steps can include: Wash the affected skin with a mild cleanser and gently pat dry. Apply a heavy cream with ingredients like ceramides to help repair the skin barrier. Wash then moisturize hands or feet immediately after coming into contact with a potential trigger. Use a layered glove method when showering to prevent contact with irritating shampoos and other products. Use gloves when washing dishes to avoid irritating soaps. Remove rings and other jewelry when you wash your hands so water and soap doesn’t linger on your skin under the jewelry. Thoroughly dry hands and feet after bathing or swimming to reduce the moisture. Apply potassium permanganate to help dry out blisters caused by dyshidrotic eczema.
- #8 Dyshidrotic eczema, causes and treatment | Eucerin UKhttps://www.eucerin.co.uk/skin-concerns/atopic-dermatitis/dyshidrotic-eczema
Pompholyx on the hands is a long-term condition that comes and goes. Getting treatment will help you control the symptoms, and ensure you’re prepared for the next bout of dyshidrosis. Treating dyshrosis depends on how severe it is. Usually, a doctor will prescribe a steroid cream or an ointment to soothe swelling and heal blisters. Our AtoControl Acute Care Cream can soothe dyshidrotic eczema flare ups on hands and body along with your doctor’s medical treatment. The cream relieves itchy skin, reducing the need to scratch while it soothes irritation and redness. The cream for dyshidrotic eczema contains a unique active ingredient complex of soothing Licochalcone A, anti-bacterial Decanediol, and anti-itching and cooling Methoxypropandiol (MPD). This, along with a high concentration of Ceramides, strengthens the skin’s barrier and relieves itchiness.
- #9 Dyshidrotic Eczema: Symptoms, Causes, Treatment, & Morehttps://www.health.com/dyshidrotic-eczema-8553239
Dyshidrotic eczema, also called pompholyx, is a type of dermatitis that causes small blisters on your hands or feet. […] Although dyshidrotic eczema is not curable, several treatment options are available to prevent severe flare-ups or shorten the length of your symptoms. […] There is no cure for dyshidrotic eczema, but there are ways to manage symptoms and prevent the development of blisters. Following a recommended skin care regimen may be effective for people with mild cases, while medications might be necessary to treat severe flare-ups. […] Adding certain steps to your skincare regimen may help you manage flare-ups, such as washing your hands with lukewarm water and mild cleanser, patting the skin dry gently after washing, using a moisturizer immediately after washing, opting for fragrance- and alcohol-free moisturizers, removing rings or other jewelry while washing your hands, and keeping fingernails short to avoid scratching your skin.
- #10 Dyshidrotic Eczema (Pompholyx) Treatment & Management: Approach Considerations, Pharmacologic Therapy, Ultraviolet Light Therapyhttps://emedicine.medscape.com/article/1122527-treatment
Topical corticosteroids are the mainstay of treatment. Typically, class I steroids are administered initially, followed by class II or III steroids. Ointments penetrate the skin better than creams do, though patients may prefer creams during the day. Topical antipruritics with pramoxine are useful. […] Systemic corticosteroids can also be used. Either oral prednisone or intramuscular triamcinolone suspension may be administered for severe episodes. Tapering of prednisone can follow intramuscular treatment. Patients should be followed and their blood pressure checked 1 week after initiation of prednisone. […] Topical calcineurin inhibitors (eg, tacrolimus and pimecrolimus) may be helpful. Some patients may benefit from this therapy. Several studies have demonstrated the efficacy and tolerability of calcineurin inhibitors in the treatment of chronic hand dermatitis.
- #11 Eczema types: Dyshidrotic eczema diagnosis and treatmenthttps://www.aad.org/public/diseases/eczema/types/dyshidrotic-eczema/treatment
Medicated soaks and cool compresses can be very effective for drying blisters. You will apply these two to four times a day for 15 minutes at a time. […] After each soak or cool compress, you’ll likely need to apply a medicated cream or ointment, such as a prescription corticosteroid. This helps to reduce the inflammation and clear the blisters. […] An antihistamine pill or other anti-itch medicine can reduce your discomfort. […] Dyshidrotic eczema can make your skin extremely dry. To reduce dryness and decrease flare-ups, your dermatologist will recommend a moisturizer or barrier repair cream. […] Skin with dyshidrotic eczema can be very itchy. Scratching often causes an infection. To clear the infection, your dermatologist will first determine what type of infection you have and then prescribe medication to treat it.
- #12 Dyshidrotic Eczema: Pictures, Symptoms, Causes & Treatmenthttps://www.webmd.com/skin-problems-and-treatments/eczema/dyshidrotic-eczema
Dyshidrotic eczema treatment cream […] Your doctor can prescribe an ointment or cream containing steroids or ceramides to ease swelling and get rid of the blisters. Your skin will take in the medicine better if you put a wet compress on it after you use the cream. If you have a severe flare-up, you might need to take a steroid drug, such as prednisone, in a pill. […] An antihistamine such as diphenhydramine (Benadryl) or loratadine (Alavert, Claritin) can help with the itch, too. You might also apply a cold, wet compress to the blisters for 15 minutes at a time several times a day. […] If these treatments don’t work well for you, you might try one of these: […] Light therapy. This uses ultraviolet (UV) light to clear up your skin. You might first get a sensitizing medication to help your skin respond better to the light.
- #13 Pompholyx (dyshidrotic eczema) | nidirecthttps://www.nidirect.gov.uk/conditions/pompholyx-dyshidrotic-eczema
Pompholyx (dyshidrotic eczema) is a type of eczema. […] You should see your GP if you have any sort of blistering skin condition. […] The main treatments your GP may recommend to treat the symptoms of pompholyx are similar to those used when treating atopic eczema, including: emollients (moisturisers) use these all the time and instead of soap to stop your skin becoming dry […] steroid cream this reduces the inflammation and irritation and helps the skin to heal. […] If your GP prescribes a steroid cream, it will probably be for a short period of time, to minimise risk of steroid side effects. […] You can also try: soaking your hands in a dilute solution of potassium permanganate (1:10,000) for 10 to 15 minutes once or twice a day for up to five days […] antihistamines to relieve the itching and help you sleep if the itchiness is keeping you awake at night.
- #14 Dyshidrosis – Diagnosis and treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/dyshidrosis/diagnosis-treatment/drc-20352348
Dyshidrosis treatment might involve: […] Your doctor may prescribe a corticosteroid cream or ointment to help clear up the blisters. Covering the treated area in plastic wrap or a moist bandage helps the skin absorb the medicine. Long-term use of steroids can cause side effects, such as spider veins and thinning of skin. […] In severe cases, your doctor may prescribe a brief course of oral steroids, such as prednisone, as a bridge to other treatments. […] If other treatments aren’t effective, your doctor may recommend light therapy. In this treatment, a UV light called narrowband UVB is directed at the affected skin. […] The calcineurin inhibitor tacrolimus (Protopic) may be helpful for people who want to limit their exposure to steroids. Do not combine this treatment with phototherapy. […] Heavy sweating of the palms and soles may contribute to dyshidrosis. Your doctor might suggest anti-perspirants or injection with botulinum toxin A. This treatment may help reduce sweating and improve the skin.
- #15 Pompholyx (dyshidrotic eczema) – EM Doctorshttps://em-doctors.com/conditions/pompholyx/
Pompholyx (dyshidrotic eczema) is a type of eczema that causes tiny blisters to develop across the fingers, palms of the hands and sometimes the soles of the feet. […] The main treatments your GP may recommend to treat the symptoms of pompholyx are similar to those used when treating atopic eczema, including: emollients (moisturisers) use these all the time and instead of soap to stop your skin becoming dry, steroid cream this reduces the inflammation and irritation and helps the skin heal. […] Your GP will probably prescribe a strong steroid cream to use for a short period of time to minimise the risk of steroid side effects. […] You can also try: soaking your hands in a dilute solution of potassium permanganate (1:10,000) for 10 to 15 minutes once or twice a day for up to 5 days, antihistamines to relieve the itching and help you sleep if the itchiness is keeping you awake at night.
- #16 Dyshidrotic Eczema (Pompholyx) Treatment & Management: Approach Considerations, Pharmacologic Therapy, Ultraviolet Light Therapyhttps://emedicine.medscape.com/article/1122527-treatment
Topical khellin and natural sunlight therapy have been suggested for patients with recalcitrant palmoplantar pompholyx. […] Tapwater iontophoresis with pulsed direct current may be helpful as adjuvant treatment. […] Markantoni et al reported excellent results from the use of oxybutynin in two patients with coexistent hyperhidrosis and dyshidrotic eczema. […] If bullae (blisters) are present, the following measures are appropriate: Apply compresses with Burow solution (10% aluminum acetate) in a 1:40 dilution until bullae resolve (usually within a few days); Compresses with a 1:10.000 solution of potassium permanganate are also effective; Drain large bullae with a sterile syringe, and leave the roof intact; Prescribe systemic antibiotics that cover Staphylococcus aureus and group A streptococci.
- #17 What Is the Fastest Way to Get Rid of Dyshidrotic Eczema?https://www.medicinenet.com/fastest_way_to_get_rid_of_dyshidrotic_eczema/article.htm
dyshidrotic eczema Treatment of dyshidrotic eczema includes topical corticosteroid creams and avoiding triggers. […] To get rid of dyshidrotic eczema fast, you may follow these 13 tips: […] Apply topical corticosteroids: Over-the-counter (OTC) corticosteroid creams or ointments help reduce skin inflammation and discomfort. You may apply them after you use cold compresses. […] Apply topical pramoxine: It is a numbing medicine and is available as creams or lotions. Topical pramoxine helps reduce itching, burning, and pain. Thus, it helps reduce the urge to scratch your skin, which may lead to delayed healing and infections. […] Take antihistamine pills: Antihistamines lower the release of chemicals that cause itching. You may take antihistamine medications available OTC as per the label instructions. They will help relieve any underlying allergic conditions that are often seen with dyshidrotic dermatitis.
- #18 Pompholyx: Causes, Symptoms, and Treatment | Doctorhttps://patient.info/doctor/pompholyx-pro
Pompholyx treatment and management […] The condition is self-limiting but, as it can be intensely itchy, symptomatic treatment may be in order. In practice, many patients require a combination of treatments. […] Large blisters can be drained under aseptic conditions. […] Antibiotics are only required if secondary infection occurs. […] Emollients, strong topical steroids to control itching, and cold compresses (eg, a 1:10.000 solution of potassium permanganate), are the usual first-line treatment. From a practical point of view, strong topical steroids work in the 'active’ phase – as the blisters are developing, Once they have dried, skin emollients with occlusion (such as plastic gloves overnight) may be useful to prevent cracking of the skin. […] Second-line treatment may be oral steroids.
- #19 Dyshidrotic Eczema: Pictures, Symptoms, Causes & Treatmenthttps://www.webmd.com/skin-problems-and-treatments/eczema/dyshidrotic-eczema
Botulinum toxin. These shots stop your hands and feet from sweating, which can trigger the blisters. […] Medicines that slow your immune system. Tacrolimus (Protopic) ointment or pimecrolimus (Elidel) cream can calm the swelling and irritation. These drugs can be options if you don’t want to take steroids. […] Draining dyshidrotic eczema blisters […] Your dermatologist can drain fluid from the blisters. Don’t try to do this yourself, as it could make your eczema worse. […] Managing dyshidrotic eczema at home […] To control the blisters at home: […] Wash your hands and feet every day. Use lukewarm water and a mild, scent-free soap. Afterward, gently pat your skin dry. […] Take your rings off before you wash your hands. Moisture can get trapped under your rings and cause more blisters.
- #20 Dyshidrotic Dermatitis Symptoms, Causes, and Treatmenthttps://www.verywellhealth.com/dyshidrotic-dermatitis-pompholyx-1069255
Topical steroids are used as first-line treatments to help control itching and reduce inflammation. Because the skin of the hands and feet is thick and absorbs medication slowly, high-strength steroids are prescribed. Oral steroids may be used for short courses in severe cases and during acute flares. […] Topical calcineurin inhibitors have been shown to be effective in some cases. These are non-steroid medications that help stimulate the release of anti-inflammatory compounds in the skin. […] Immunosuppressants (such as methotrexate) are sometimes prescribed in severe cases that aren’t responding to other treatments. They’re most often used along with other therapies. […] Over-the-counter oral antihistamines don’t improve the rash but may help relieve itching. Ask your healthcare provider if these may be of help in your situation.
- #21 Pompholyx (dyshidrotic) eczema – National Eczema Societyhttps://eczema.org/information-and-advice/types-of-eczema/pompholyx-eczema-2/
Treatment may include a short course of an immunosuppressant drug. […] Alitretinoin (known as Toctino) is an oral treatment licensed for use in adults with severe chronic hand eczema (including pompholyx) that has not responded to treatment with potent topical steroids. […] Phototherapy (UVB or PUVA), using either UVB or UVA rays administered by a special foot/hand light box, may be recommended if this treatment option is available locally to you. […] Occasionally, for very severe outbreaks of pompholyx eczema, a short course of oral steroid tablets is prescribed.
- #22 Pompholyx (dyshidrotic eczema) | NICS Wellhttps://www.nicswell.co.uk/conditions-and-treatments/pompholyx-dyshidrotic-eczema
Pompholyx (dyshidrotic eczema) is a type of eczema that causes tiny blisters to develop across the fingers, palms of the hands and sometimes the soles of the feet. […] The main treatments your GP may recommend to treat the symptoms of pompholyx are similar to those used when treating atopic eczema, including: emollients (moisturisers) use these all the time and instead of soap to stop your skin becoming dry; steroid cream this reduces the inflammation and irritation and helps the skin heal. […] If your pompholyx keeps returning or is severe and does not get better with the above treatments, your GP may refer you to a specialist in treating skin conditions (dermatologist). […] A dermatologist may recommend 1 of the following treatments: phototherapy controlled exposure to ultraviolet (UV) light; steroid tablets or very strong steroid cream; immunosuppressant creams or ointments, such as pimecrolimus or tacrolimus; immunosuppressant tablets or capsules, such as ciclosporin or azathioprine; alitretinoin capsules medicine that helps improve severe eczema affecting the hands when other treatments have not worked.
- #23 Dyshidrosis (dyshidrotic eczema, pompholyx) – Hello Doktorhttps://hellodoktor.com/en/dyshidrosis-dyshidrotic-eczema-pompholyx/
How is dyshidrosis treated? […] Depending on the severity of your signs and symptoms, treatment options may include: […] High-potency corticosteroid creams and ointments may help speed the disappearance of the blisters. […] If other treatments aren’t effective, your doctor may recommend a special kind of light therapy that combines exposure to ultraviolet light with drugs that help make your skin more receptive to the effects of this type of light. […] Immune-suppressing ointments. Medications such as tacrolimus (Protopic) and pimecrolimus (Elidel) may be helpful for people who want to limit their exposure to steroids. […] Botulinum toxin injections. Some doctors may consider recommending botulinum toxin injections to treat severe cases of dyshidrosis.
- #24 Hand and foot eczema (endogenous, dyshidrotic eczema, pompholyx) – Clinical Treehttps://clinicalpub.com/hand-and-foot-eczema-endogenous-dyshidrotic-eczema-pompholyx/
The acute, recurrent, and persistent course of the hand and foot eczema will largely determine the choice of treatment modalities. […] Possible treatment options include topical agents, ultraviolet (UV) phototherapy, and systemic therapy. Dry and fissured skin lesions are best treated with highly lipophilic ointments, possibly combined with occlusive or semi-occlusive dressings to increase penetration. Keratolytic agents such as urea or salicylic acid are helpful in hyperkeratotic eczema, whereas moist and oozing skin may benefit from hydrophilic creams or gels. Desiccative agents have shown value in dyshidrotic forms of eczema. Antiseptics should be considered to avoid superinfection, especially in erosive or fissured lesions. […] Topical corticosteroids of medium to high potency are the mainstay of all topical therapies of hand eczema. The topical calcineurin inhibitor tacrolimus may also be effective, especially for long-term treatment, but should not be combined with UV therapy. Pimecrolimus has shown less efficacy.
- #25 Hand and foot eczema (endogenous, dyshidrotic eczema, pompholyx) – Clinical Treehttps://clinicalpub.com/hand-and-foot-eczema-endogenous-dyshidrotic-eczema-pompholyx/
Calcipotriol ointment may show beneficial effects in chronic hand eczema, especially in the hyperkeratotic subtype, and may reflect a topical steroid-sparing alternative. […] PsoralenUVA (PUVA) therapy is the most effective UV-light treatment option for chronic, recurrent hand and foot eczema. UVA phototherapy or narrowband UVB (NB-UVB) phototherapy may also be useful. […] Systemic treatment is frequently required in severe, refractory, or persistent hand and foot eczema. Systemic corticosteroids are recommended for short-term use only. Prednisone 0.5-1.0 mg/kg/day tapered over 2 weeks is a typical regimen. Systemic retinoids such as alitretinoin or acitretin are helpful if pregnancy prevention programs are followed strictly. […] New emerging therapies include dupilumab, a monoclonal antibody blocking the IL-4/IL-13 pathway. Topical Janus kinase (JAK) inhibitors such as delgocitinib may improve chronic hand eczema despite its subtype, and should be useful in therapy-refractory chronic hand eczema. Oral JAK inhibitors will undoubtedly be useful for hand eczema in the future. […] Intradermal localized botulinum toxin A will reduce sweating and may therefore be helpful as adjuvant therapies in dyshidrotic forms.
- #26 Dyshidrotic Eczema: Symptoms, Causes, and Treatments | MyEczemaTeamhttps://www.myeczemateam.com/resources/dyshidrotic-eczema-symptoms-causes-and-treatments
Until those drugs are approved, there are several treatment options for people diagnosed with dyshidrotic eczema. […] Moisturizing the skin is one of the key treatments Dr. Kim recommends to people diagnosed with eczema. […] Another first line of defense against atopic dermatitis is a corticosteroid cream or ointment. […] Oral steroids are generally discouraged and only used in very unique, severe, refractory cases. […] Your dermatologist may prescribe a cream containing calcineurin inhibitors. […] If your dyshidrotic eczema is persistent and continues even after other treatments, your dermatologist may recommend phototherapy a technique that exposes the affected skin to either natural sunlight, ultraviolet A light, or ultraviolet B light. […] In some cases, people with dyshidrotic eczema may develop swelling, crusting, or pus-filled blisters as the result of a potential bacterial infection. If this occurs, your dermatologist may prescribe oral antibiotics to help treat the infection.
- #27 Dyshidrotic Eczema: Symptoms, Causes, Treatment | National Eczema Associationhttps://nationaleczema.org/types-of-eczema/dyshidrotic-eczema/
Once you are diagnosed with dyshidrotic eczema, many cases can improve quickly with a short course of topical corticosteroids combined with soaking or applying cool compresses to affected areas a few times a day to help dry out blisters. […] Sometimes dyshidrotic eczema also presents with a fungal infection on the hands or feet. In these cases, the dermatologist may prescribe an anti-fungal medication. […] When dyshidrotic eczema is severe or flares happen often, dermatologists may prescribe phototherapy, topical calcineurin inhibitors (TCIs) or oral steroids. […] Occasionally, treatments for sweating such as topical anti-perspirants or botulinum toxin (botox) injections are used to control the sweaty hands and feet that can trigger the condition. […] Everyone experiences eczema differently, so be sure to consult with your healthcare provider to determine the best course of treatment for your individual symptoms.
- #28 Dyshidrotic Eczema (Pompholyx) Treatment & Management: Approach Considerations, Pharmacologic Therapy, Ultraviolet Light Therapyhttps://emedicine.medscape.com/article/1122527-treatment
Recalcitrant dyshidrotic eczema may be treated with dupilumab. […] The Janus kinase (JAK) inhibitor upadacitinib has also been tried in this setting. […] Paradoxically, although UVA is sometimes linked as a possible cause of dyshidrotic eczema, it has also been used to treat this condition, either alone or in combination with oral or topical psoralen. […] Topical application of 8-methoxypsoralen plus UVA (bath-PUVA) has been demonstrated to be the preferred method for the treatment of dyshidrotic eczema, compared with oral PUVA. […] For nickel-sensitive patients, a 3- to 4-week low-nickel diet should be considered. […] Dyshidrotic eczema patients should be advised to avoid known contact irritants or allergens, to reduce stress, to follow a hand care regimen, and to use regular prophylactic emollients. […] Consultation with a psychologist may be helpful for stress reduction with biofeedback therapy and other techniques.
- #29 Dyshidrotic Eczema (Pompholyx): Background, Etiology, Epidemiologyhttps://emedicine.medscape.com/article/1122527-overview
Treatments for dyshidrotic eczema include the following: […] First-line treatment – High-strength topical steroids and cold compresses; systemic steroids are also used […] Ultraviolet A (UVA) or UVA-1 light therapy, alone or with oral or topical psoralen (PUVA); UVB therapy has also shown utility […] Topical calcineurin inhibitors […] OnabotulinumtoxinA injections […] For severe refractory pompholyx – Azathioprine, methotrexate, mycophenolate mofetil, cyclosporine, or etanercept […] Nickel chelators (eg, disulfiram) occasionally used in nickel-sensitive patients […] Dietary avoidance of nickel and cobalt for nickel- and cobalt-sensitive patients […] Individuals with dyshidrotic eczema should be educated about the difficulty of achieving successful treatment. They should be informed that the typical first-line treatments for the blisters of this condition are high-strength topical steroids and cold compresses and that additional treatments that might be helpful include stress reduction (possibly involving consultation with a mental health professional and potentially including biofeedback therapy) and hand care measures (eg, use of moisturizers and emollients).
- #30 Dyshidrotic Eczema (Pompholyx) Treatment & Management: Approach Considerations, Pharmacologic Therapy, Ultraviolet Light Therapyhttps://emedicine.medscape.com/article/1122527-treatment
For severe refractory pompholyx, azathioprine, methotrexate, mycophenolate mofetil, cyclosporine, or etanercept may be helpful. […] Nickel chelators (eg, disulfiram) occasionally are used in nickel-sensitive patients who demonstrate a positive oral provocation test. […] Khellin, a furanochromone similar to methoxypsoralen, may be used in combination with photochemotherapy (sun exposure) for recalcitrant palmoplantar cases. […] Alitretinoin (9-cis retinoic acid) activates the retinoid X receptor and all retinoic receptors. […] Various other potential agents (eg, topical bexarotene, systemic alitretinoin, leukotriene receptor antagonists, leukotriene synthesis inhibitors, phosphodiesterase [PDE]-4 inhibitors, and monoclonal antibodies) have been shown to be effective for the treatment of chronic hand dermatitis and other inflammatory conditions, including atopic dermatitis.
- #31 Hand eczema, hand dermatitishttps://www.pcds.org.uk/clinical-guidance/eczema-hand-dermatitis
Pompholyx (dyshidrotic eczema): a specific type of eczema that usually presents periodically with intensely itchy vesicles that predominate on the palms and sides of fingers. On occasions large blisters may develop. […] The first-line systemic treatment for moderate-severe hyperkeratotic hand / foot eczema are the systemic retinoids acitretin (Neotigason) and alitretinoin (Toctino). Systemic retinoids are teratogenic and so all women of childbearing age need to be on a pregnancy prevention program. […] Other treatments used in Secondary Care include extremity PUVA (phototherapy), methotrexate, and ciclosporin.
- #32 Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx – PubMedhttps://pubmed.ncbi.nlm.nih.gov/10188683/
We describe 5 patients with severe pompholyx who did not respond to conventional therapy or who had debilitating side effects from corticosteroids. Low-dose methotrexate was added to their treatment regimens and led to significant improvement or clearing with a favorable side-effect profile. In all 5 patients the need for oral corticosteroid therapy was substantially decreased or eliminated, thus decreasing potential corticosteroid-induced morbidity. […] In this uncontrolled series of patients with recalcitrant palmoplantar pompholyx, methotrexate was an effective treatment and acted as a steroid-sparing agent.
- #33 Pompholyx: Causes, Symptoms, and Treatmenthttps://patient.info/skin-conditions/atopic-eczema/pompholyx
These medications are only used in patients who do not get better with regular treatments and light therapy. They work by affecting the immune system to reduce inflammation. Examples are methotrexate, azathioprine, ciclosporin and mycophenolate tablets. […] In some cases of pompholyx with excessive sweating (hyperhidrosis) injections of botulinum toxin into the skin might be helpful. […] For patients allergic to nickel, they should avoid touching anything with nickel. A special kit can test everyday items for nickel. […] If symptoms still occur, other steps can be taken to reduce nickel in the body. This might include eating a low-nickel diet. […] If pompholyx does not get better with the above treatments, there are other options available.
- #34 Eczema types: Dyshidrotic eczema overviewhttps://www.aad.org/public/diseases/eczema/types/dyshidrotic-eczema
This type of eczema causes tiny, intensely itchy blisters on the hands or feet. It is also called pompholyx. […] With a dermatologists help, many people discover what triggers their blisters. Avoiding what triggers the blisters helps to reduce flare-ups. […] While a dermatologist can help you reduce flare-ups, there is no cure for dyshidrotic eczema. Sometimes, treatment fails to prevent flare-ups. If you keep getting flare-ups, its important to keep working with your dermatologist to try other options. […] Recent research has led to new treatments for difficult-to-treat dyshidrotic eczema. One newer option is a medication called dupilumab. This medication belongs to a class of medications called biologics. While dupilumab has only been given to relatively few patients, it has helped them when nothing else worked.
- #35 Two Cases of Recalcitrant Dyshidrotic Eczema Treated With Dupilumab – JDDonline – Journal of Drugs in Dermatologyhttps://jddonline.com/articles/two-cases-of-recalcitrant-dyshidrotic-eczema-treated-with-dupilumab-S1545961621P0558X/
Dyshidrotic eczema, also known as dyshidrosis or pompholyx when involving larger bullae, is a chronic, relapsing palmoplantar dermatosis characterized by intensely pruritic and frequently painful deep-seated vesicles and bullae. […] Basic treatment strategies for all patients with dyshidrotic eczema include avoidance of contact irritants, gentle skin care to reduce irritation, and use of emollients to restore barrier function. […] Mild to moderate cases may be treated with topical steroids, calcineurin inhibitors, and ultraviolet light (narrow band UV-B and UVA1). […] Treatment failure with first line topical agents is common, and more potent treatments such ultra-high potency topical corticosteroids under occlusion, systemic corticosteroids, psoralen-ultraviolet A therapy (PUVA), and systemic immunosuppressants such as methotrexate, mycophenolate mofetil, cyclosporine, and azathioprine are often used.
- #36 Two Cases of Recalcitrant Dyshidrotic Eczema Treated With Dupilumab – JDDonline – Journal of Drugs in Dermatologyhttps://jddonline.com/articles/two-cases-of-recalcitrant-dyshidrotic-eczema-treated-with-dupilumab-S1545961621P0558X/
In this series, we discuss two cases of recalcitrant dyshidrotic eczema that had profound improvement after treatment with dupilumab. […] Treatment with 60mg of intramuscular triamcinolone led to complete resolution of symptoms, but recurrence occurred within 1 month. He was started on dupilumab 600mg subcutaneously (SQ) followed by 300mg SQ every other week with clobetasol as needed. At follow up, he noted rapid and profound improvement beginning within 1 week of his first dose. At 6 months, improvement was sustained without application of clobetasol. […] He did experience some improvement with oral prednisone, with symptoms returning to baseline.
- #37 Dyshidrotic eczema: Effective management strategies – Harvard Healthhttps://www.health.harvard.edu/diseases-and-conditions/dyshidrotic-eczema-effective-management-strategies
Dyshidrotic eczema treatment options include both over-the-counter and prescription medications. First-line therapy usually involves topical eczema creams or ointments that are applied to the skin. Your dermatologist may prescribe oral and injectable medications in severe cases. […] Treatment options include topical corticosteroids such as betamethasone and clobetasol, topical calcinurin inhibitors such as pimecrolimus and tacrolimus, short courses of oral corticosteroids, oral Janus kinase (JAK) inhibitors such as upadacitinib and baricitinib, dupilumab, an injectable medication used for the treatment of eczema, oral immunosuppressive medications such as methotrexate, and phototherapy. […] Your doctor may prescribe an antibiotic if he or she suspects a skin infection. […] While treatment options can help manage the episodic flares of dyshidrotic eczema, there is no cure for the skin condition. You can manage your symptoms and prevent flares through certain lifestyle changes and adopting good skin habits. […] Flares of dyshidrotic eczema can recur despite preventive strategies. You can try various home remedies and natural treatments for relief.
- #38 Pompholyx: a review of clinical features, differential diagnosis, and management – PubMedhttps://pubmed.ncbi.nlm.nih.gov/20642293/
Pompholyx is a vesicobullous disorder of the palms and soles. The condition is hard to treat because of the peculiarities of the affected skin, namely the thick horny layer and richness of the sweat glands. In this article, we review the available therapies, and score the treatments according to the level of evidence. The cornerstones of topical therapy are corticosteroids, although calcineurin inhibitors also seem to be effective. Topical photochemotherapy with methoxsalen (8-methoxypsoralen) is as effective as systemic photochemotherapy or high-dose UVA-1 irradiation. Systemic therapy is often necessary in bullous pompholyx. Corticosteroids are commonly used although no controlled study has been published to date. For recalcitrant cases, corticosteroids are combined with immunosuppressants. Alitretinoin has efficacy in chronic hand dermatitis including pompholyx. Another evolving treatment seems to be the intradermal injection of botulinum toxin. Radiotherapy might be an option for selected patients not responding to conventional treatment. In practice, patients benefit most from a combination of treatments.
- #39 Dyshidrotic Eczema and Tap Water Iontophoresis – Daavlinhttps://daavlin.com/blog-post/dyshidrotic-eczema-and-tap-water-iontophoresis/
Although tap water iontophoresis is most commonly used for hyperhidrosis, it has a long and successful history of use in eczema treatment as well. […] In particular, dyshidrotic eczema (also known as pompholyx or dyshidrosis) can be treated with iontophoresis as both an adjunct to topical corticosteriod treatment, and as a stand alone intervention. […] As a stand alone intervention, 17 out of 20 patients in a split-body tap water iontophoresis trial showed improvement in their dyshidrotic excema symptoms, but only on the treated side, compared to a complete lack of improvement in the untreated side. […] When used in conjunction with topical corticosteriods, the time for clearance has been reported to be similar to high potency topical corticosteroids, but with the added benefit of a much increased remission time (average of 24.8 weeks vs 8.35 weeks). […] Overall, tap water iontophoresis should be considered as an effective stand alone or add-on treatment.
- #40https://www.contemporarypediatrics.com/view/pompholyx
This child has pompholyx, a recurrent dermatitis that occurs mainly in teenagers and young adults. It is characterized by a noninflammatory but pruritic vesicular or bullous rash with a predilection for the hands and feet. […] The clinical course of dyshidrotic eczema can range from mild and self-limited to chronic and severe. In some patients, it can be debilitating. Scratching the lesions can deroof the vesicles and bullae, which may lead to bacterial superinfection. […] Patients are advised to avoid exposure to harsh soaps or metals that may worsen the condition. The mainstay of treatment is potent topical corticosteroids and cool compresses. Systemic corticosteroids for severe, widespread cases and corticosteroid-sparing medications for long-term use may be needed. Occlusive therapy with pimecrolimus may be useful in patients with severe hand and foot involvement. However, its potential adverse effects preclude it from being first-line therapy. Psoralen plus UVA therapy has also been shown to be beneficial. In the chronic phase, emollients and lubrication can help prevent painful fissures. Despite these measures, the condition can be very frustrating for the patients and their families. […] This patient was treated with a wet dressing followed by mometasone cream 0.1%, applied topically once daily for 2 weeks. At follow-up, his symptoms and rash had resolved, leaving only mild postinflammatory hyperpigmentation.
- #41https://www.helloyanyee.com/en-us/blogs/eczema/pompholyx-eczema-quick-guide-home-treatment-tips-2022?srsltid=AfmBOor6N_iom9SFVTIIKW0UriQXW9KZg6CzsaaNgGh7oh3ARRPWej8C
Wrap your hands and feet at night with bandages – this can help to protect the blisters and ensure no unwanted popping happens whilst you sleep. […] Footwear should be kept clean and dry and where possible, open to the air. Avoid plastic shoes or tight, enclosed trainers that may cause your feet to sweat more than normal. […] Soaking your hands in a dilute solution of potassium permanganate (1:10000) for 10-15 minutes up to two times a day for 5 days max. This is astringent and antiseptic so can be a great way to treat your skin. […] If your hands and feet begin to show a yellow crusting and become particularly sore and painful, theres a possibility you might have a bacterial infection. This will require antibiotics and you should see a doctor or health professional immediately. […] Topical steroids – this isnt something we advocate, but can be used to control a flare up if youre desperate. […] Phototherapy – this is something that could be recommended if you see a dermatologist and is for more severe, long term cases.
- #41https://www.helloyanyee.com/en-us/blogs/eczema/pompholyx-eczema-quick-guide-home-treatment-tips-2022?srsltid=AfmBOor6N_iom9SFVTIIKW0UriQXW9KZg6CzsaaNgGh7oh3ARRPWej8C
Also referred to as dyshidrotic eczema (dont worry we have no idea how you say that word either) – this is a type of skin disease that affects specifically the hands and feet. […] Theres some simple, straight forward things we can do here to help prevent and treat this form of eczema. […] Try our Mugwort Mist to cut out the intense itch. Not only is it a fantastic way to nourish and replenish dry skin, its also a very effective antidote to itchy skin. […] Avoid anything that might irritate your skin! […] Use an emollient as a soap substitute and wear cotton lined gloves where you can, especially at night. […] Wash with luke warm water – not hot or cold. […] Relax! Mindfulness, meditation, yoga, exercise. […] Try not to pop the blisters! Let them heal naturally and your body will thank you.
- #42 Eczema types: Dyshidrotic eczema diagnosis and treatmenthttps://www.aad.org/public/diseases/eczema/types/dyshidrotic-eczema/treatment
If you frequently get blisters, making an appointment to see a board-certified dermatologist can be helpful. Several different diseases can cause blisters, including dyshidrotic eczema. To get effective treatment, you need an accurate diagnosis. […] The following explains how dermatologists diagnose and treat dyshidrotic eczema, which can cause blisters on your hands, feet, or both. […] If your dermatologist thinks that the dyshidrotic eczema could be due to an allergy, an allergy test called patch testing may be recommended. During patch testing, small amounts of substances that you may be allergic to are placed on your skin often the skin on your back. […] If you do, your dermatologist will create a treatment plan tailored to your needs. […] Your dermatologist will create a treatment plan for you to follow at home. This treatment plan will be tailored to your individual needs and may include the following:
- #43 Dyshidrotic Eczema: Symptoms, Causes, Treatment | National Eczema Associationhttps://nationaleczema.org/types-of-eczema/dyshidrotic-eczema/
Knowing your triggers can help you avoid them. Patch testing with a dermatologist is one way to identify possible triggers, if you suspect certain ingredients or allergens. […] Your doctor might also suggest nutritional changes to reduce the amount of nickel or cobalt in your diet if you have a hypersensitivity.
- #44 Eczema types: Dyshidrotic eczema diagnosis and treatmenthttps://www.aad.org/public/diseases/eczema/types/dyshidrotic-eczema/treatment
If you continue to have flare-ups after following the treatment plan prescribed by your dermatologist, tell your dermatologist. It can take time to find the right treatment for dyshidrotic eczema. […] If you sweat profusely where you have blisters, treatment that helps to control the sweating can be effective. […] Applying corticosteroids to your skin can help lessen this hypersensitivity, but some patients need stronger (or different) medication. […] Studies show these medications can effectively treat dyshidrotic eczema. […] If this is an option, you will need to go to your dermatologist’s office or a hospital for treatment. […] If you have a hypersensitivity to either of these metals, a change in diet may help reduce flares-ups. […] If you have painful blisters on your feet, you may need bed rest. Blisters on the hands may require a break from work. […] Stress leads to flare-ups for many people with dyshidrotic eczema. […] Self-care can help reduce flare-ups.
- #45 Dyshidrotic Eczema: Pictures, Symptoms, Causes & Treatmenthttps://www.webmd.com/skin-problems-and-treatments/eczema/dyshidrotic-eczema
Wear gloves with cotton liners whenever your hands come into contact with water, such as while washing dishes. […] Put a thick moisturizer on your hands and feet every time you shower or wash. Rub it on while your skin is still wet to seal in water. You also might use a cream that has dimethicone to protect your skin. […] Turn on a humidifier in dry weather to keep your skin from cracking. […] If allergies set off your eczema, try to stay away from things that trigger them. […] Don’t scratch the blisters. You’ll make them worse. […] Dermatologists suggest avoiding direct contact with items that contain high levels of nickel or cobalt, such as jewelry, clothing fasteners, or tools, to avoid skin irritation or allergic reactions. […] Takeaways […] Dyshidrotic eczema is a skin condition that causes itchy blisters on the palms, fingers, feet, and toes. It can also lead to red, cracked skin and changes in nail appearance. While there’s no cure, treatments such as creams with steroids, antihistamines, or light therapy can help manage symptoms. Good hygiene, moisturizing, and avoiding triggers can also help control flare-ups.
- #46 Pompholyx: Causes, Symptoms, and Treatmenthttps://patient.info/skin-conditions/atopic-eczema/pompholyx
Pompholyx is a type of eczema where there are itchy blisters on the hands and feet, followed by inflamed and dry skin. The first step in managing pompholyx is to identify and avoid things that make it worse. Treatment includes creams and ointments to reduce inflammation and irritation. If the symptoms are severe and persistent, a short course of steroid tablets might be helpful. […] Pompholyx can often get better on its own, but treatment can help reduce symptom duration, recurrence and discomfort. […] Avoid anything that seems to make the symptoms worse. Try to limit time spent in wet conditions and using strong cleansers. Make sure to wear protective gloves and footwear. […] As with eczema generally, moisturising creams or ointments are helpful for dry, peeling or cracked skin that act as a barrier against water or chemicals.
- #47 Dyshidrotic Eczema (Dyshidrosis): Symptoms, Causes, Treatmentshttps://my.clevelandclinic.org/health/diseases/17728-dyshidrotic-eczema
Dyshidrotic eczema is a common skin condition that causes blisters and itchy skin. Effective treatments include at-home treatments, therapies and prescription medicines. […] For many people, getting rid of dyshidrotic eczema starts with an at-home skin care routine. Home care may include: Using warm water instead of hot water when washing your hands. Soaking your hands and feet in cool water to improve your symptoms. Applying cool compresses as needed to relieve itching and irritation. […] Your healthcare provider may recommend over-the-counter (OTC) medications such as topical corticosteroid creams or ointments that you rub directly on your skin. […] In more severe cases of dyshidrotic eczema, your healthcare provider may prescribe or recommend the following medications or treatments to help relieve your symptoms: System-wide corticosteroids: If corticosteroid creams or ointments dont relieve your symptoms, your healthcare provider may prescribe an oral corticosteroid, like prednisone (Deltasone). System-wide nonsteroidal immunosuppressive drugs: Long-term use of oral steroids may be unhealthy, so your healthcare provider may prescribe medications such as methotrexate tablets (Rheumatrex), mychophenolate tablets (CellCept) or dupilumab injections (Dupixent). Phototherapy: Phototherapy uses ultraviolet light, usually ultraviolet B (UVB), from special lamps.
- #48 Dyshidrotic Eczema (Dyshidrosis): Causes, Pictures, and Morehttps://www.healthline.com/health/dyshidrotic-eczema
Dyshidrotic eczema, also known as pompholyx, dyshidrosis, or palmoplantar eczema, is a skin condition in which blisters develop on your soles, palms, or fingers. […] Keep reading to learn more about dyshidrotic eczema, including its causes, symptoms, and treatment options. […] If your symptoms are mild, a doctor may recommend: using a medicated soak or applying a cool compress for 15 minutes two to four times per day, applying a moisturizer or barrier repair cream to damp skin after a soak or bath, applying a corticosteroid cream to help heal the blisters and reduce inflammation, using anti-itch medication in the form of a pill or cream, practicing meditation and other techniques to manage stress, taking note of any jewelry, soaps, and other products that seem to make symptoms worse and avoiding them, keeping nails short to prevent scratching, which could lead to an infection.
- #49 Dyshidrotic Eczema (Dyshidrosis): Causes, Pictures, and Morehttps://www.healthline.com/health/dyshidrotic-eczema
More severe or frequent symptoms might require other treatments, such as: prescription steroid creams, pimecrolimus cream, tacrolimus ointment, systemic medications to suppress the immune system, light treatment at a doctor’s office (but avoiding unprotected sun exposure and tanning beds), getting plenty of rest, if possible, biofeedback or other techniques to help manage stress. […] You may be able to manage some of the symptoms at home, but it’s best to make an appointment with a doctor for a diagnosis and treatment plan.
- #50 Holistic Treatment of Dyshidrotic (Pompholyx) Eczema | Yin Yang Dermatology â Holistic Healing for Skin, Los Angeleshttps://www.yinyangdermatology.com/eczema/dyshidrotic-pompholyx-eczema/
Dyshidrotic (or Pompholyx) Eczema is a common skin disorder characterized by blistering lesions primarily on the hands (although the feet can also be affected). The typical pattern of dyshidrotic eczema consists of a blistering phase where fluid-filled bumps appear deep in the skin which may be itchy or burning. This is followed by a dry phase with thickening of the skin, cracking or crusting and possible itching. These phases can alternate in a repeating cycle, or may sometimes occur at the same time. […] Holistic treatment for dyshidrotic eczema (or pompholyx) is effective with long-lasting results. When the body is brought into balance, other symptoms (such as digestive complaints, fatigue, insomnia and others) will also be addressed, resulting in overall health and wellness. […] A treatment course for eczema varies depending on the severity and duration of the condition. Mild cases with a recent onset generally clear up within a month of treatment. Serious cases can take up to four months of treatment (or longer) to fully resolve. We treat until the condition is stable. Once this happens, the body naturally remains in a healthy state on its own.
- #51 Holistic Treatment of Dyshidrotic (Pompholyx) Eczema | Yin Yang Dermatology â Holistic Healing for Skin, Los Angeleshttps://www.yinyangdermatology.com/eczema/dyshidrotic-pompholyx-eczema/
Herbal medicine is one of the most effective methods to address underlying imbalances and completely heal dyshidrotic eczema. Topical herb soaks and creams provide immediate relief to the hands (and/or the feet) during the blistering phase. During drier phases, salves and creams are used. Internal herbal teas are key for complete and long-term healing from within. […] Holistic treatment for dyshidrotic eczema mainly relies on herbs and botanicals. Some patients also do a course of acupuncture treatment, but its generally for the underlying stress or for overall health and well-being. We rarely recommend acupuncture for the specific treatment of dyshidrotic eczema as herbal medicine is far more direct and powerful.
- #52 Pompholyx eczema » Alban Acupuncturehttps://albanacupuncture.com/conditions/pompholyx-eczema/
Pompholyx eczema is a specific type of eczema on the hands and feet that causes vesicles, itching, fissures, and crusting. […] Acupuncture and Chinese medicine helps to relieve itching and reduce inflammation in pompholyx eczema. […] Chinese herbs are thought to regulate the immune system which can lead to long-term improvement. […] The treatment will usually combine herbal medicine taken as a strong tea, topical herbal medicine, and acupuncture. […] The herbal formula is customized to address the specific imbalance causing your eczema. […] External herbal soaks, creams, and ointments can be directly applied to the affected areas to which provide relief from itching, redness, and inflammation. […] In Traditional Chinese Medicine (TCM), the approach to treating pompholyx eczema combines herbs drank as strong teas as well as external therapies such as herbal soaks and creams.
- #53 Holistic TCM Dermatology: Pompholyx (Dishydrotic) Eczema – Betsy Gordon Acupuncturehttps://betsygordonacupuncture.com/holistic-tcm-dermatology-pompholyx-dishydrotic-eczema/
Pompholyx eczema, or dyshidrotic eczema, is a chronically recurring inflammatory skin condition which can fully resolve with treatment by holistic, traditional Chinese medicine (TCM) dermatology. […] Standard treatment is a topical steroid cream, which temporarily prevents cells from producing inflammatory chemicals. This can very effectively relieve itching and irritation, and it can help prevent infection as a result of frequent itching and broken skin. It will not prevent the eczema from returning. […] TCM has been treating inflammatory skin conditions for millennia using acupuncture, herbal medicine, and a corresponding holistic approach to diet and lifestyle. […] TCM herbal treatment for pompholyx is potent and focused on the present symptoms. Treatment does not stop as soon as the skin stops itching. […] It is important to understand that the causes of pompholyx eczema are much deeper than the skin. Complete holistic treatment can take up to 6 months and cost between $100 and $400. […] Think of it as immune system rehabilitation. Natural, safe, and sometimes slow medicine.
- #54 Reddit – The heart of the internethttps://www.reddit.com/r/eczema/comments/3m0mg5/my_severe_dyshidrotic_eczema_journey_and_what/
About nine months ago, my dermatologist reluctantly put me on a strong course of Prednisone. […] During this time, I was still on steroid creams and ointments daily. […] I started to taper the prednisone, and once I got down to 30mg a day and 2g of mycophenolate, the blisters roared back to life as though they’d never skipped a beat. […] I was doing steroid creams 2x a day and the ointment at night with gloves and socks. I was doing bleach baths, apple cider vinegar baths and drinks every day, and using essential oils every day. […] I talked with u/benf101 about what had worked for him/her, and followed the links s/he gave me. […] There is evidence that dyshidrotic eczema may be a food allergy and/or indicative of an extreme candida overgrowth in the gut. […] Diet Changes: For three months thus far, I have completely cut out wheat, refined sugars, alcohol and switched to a low-carb, whole food diet (with the majority of my carbs coming from root veggies).
- #55 Reddit – The heart of the internethttps://www.reddit.com/r/eczema/comments/3m0mg5/my_severe_dyshidrotic_eczema_journey_and_what/
I started taking strong probiotics twice a day (once in the morning, once in the evening). I also started using oil of oregano. […] About two weeks after starting this regiment, my blisters started disappearing. […] After a month, I woke up to my first day with NO new blisters in two years. […] This morning, I went to my standing dermatologist appointment. He examined my hands, and was very surprised. […] It’s been close to three months and I feel like a new person. […] I’m not saying that what I did will work for everyone, but if you have as bad a case as I did, try it. You have nothing to lose.
- #56 Dyshidrotic Eczema (Dyshidrosis): Symptoms, Causes, Treatmentshttps://my.clevelandclinic.org/health/diseases/17728-dyshidrotic-eczema
Your body is unique. You may respond well to an at-home skin care routine and OTC medications, or you may require prescription-strength corticosteroid creams or ointments, like clobetasol (Cormax). Dyshidrotic eczema usually goes away with treatment, but it may come back later. […] A good skin care routine and medicines such as antihistamines can help you manage your symptoms. Other therapies, including phototherapy, can help as needed. […] With a proper skin care routine, you can reduce the impact of dyshidrotic eczema.