Materiały źródłowe

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65831/

  Surgical exploration may be required to determine operability. […] Radiation therapy must be carried to high doses for any significant probability of permanent control. The treatment volume must include all of the maxillary antrum and involved hemiparanasal sinus and contiguous areas. […] Patients with recurrent disease should consider chemotherapy clinical trials. Chemotherapy for recurrent squamous cell cancer of the head and neck has been shown to be efficacious as palliation and may improve a patient’s quality of life and length of survival. Various drug combinations, including cisplatin, fluorouracil, and methotrexate, are effective. […] Treatment of tumors of the paranasal sinuses and of the nasal cavity should be planned on an individual basis because of the complexity involved.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK66003/

  Paranasal sinus and nasal cavity cancer is a type of head and neck cancer. […] There are different types of treatment for patients with paranasal sinus and nasal cavity cancer. […] Patients with paranasal sinus and nasal cavity cancer should have their treatment planned by a team of doctors with expertise in treating head and neck cancer. […] The following types of treatment are used: Surgery, Radiation therapy, Chemotherapy. […] After the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy. […] Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing.

• #1 Nasal Cavity (Nose) and Paranasal Sinus Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/treating.html

  If youve been diagnosed with nasal cavity or paranasal sinus cancer, your cancer care team will discuss your treatment options with you. Its important that you think carefully about each of your choices. You will want to weigh the benefits of each treatment option against the possible risks and side effects. […] Treatment for nasal cavity or paranasal sinus cancer may include: Surgery for Nasal Cavity and Paranasal Sinus Cancers, Radiation Therapy for Nasal Cavity and Paranasal Sinus Cancers, Chemotherapy for Nasal Cavity and Paranasal Sinus Cancers, Targeted Drug Therapy for Nasal Cavity and Paranasal Sinus Cancers, Immunotherapy for Nasal Cavity and Paranasal Sinus Cancers, Supportive Treatment for Nasal Cavity and Paranasal Sinus Cancers. […] In general, surgery is the first treatment for cancers of the nasal cavity and paranasal sinuses. For bigger cancers that cannot be removed with surgery alone, radiation might be added or be the main treatment. Chemotherapy given with radiation might also be used.

• #1 Nasal and sinus cancer

  https://www.nhs.uk/conditions/nasal-and-sinus-cancer/

  The treatment recommended for you will depend on several factors, including the stage at which the cancer was diagnosed, how far it’s spread, and your general level of health. […] Treatment may include: […] surgery to remove a tumour this can be performed through open surgery or as keyhole surgery through the nose (endoscopic microsurgery) […] radiotherapy where high-energy radiation is used to kill the cancerous cells, shrink a tumour before surgery, or destroy small pieces of a tumour that may be left after surgery […] chemotherapy where medicine is used to help shrink or slow down the growth of a tumour, or reduce the risk of the cancer returning after surgery. […] Your treatment will be organised by a head and neck cancer multidisciplinary team (MDT), who’ll discuss the treatment options with you. […] A combination of treatments will often be recommended. […] The Cancer Research UK website has more information about the treatment of nasal and sinus cancer.

• #1 Mayo Clinic Health Library – Nasal and paranasal tumors | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20198269

  Most nasal and paranasal tumors are treated with surgery to remove the tumor. Treatment for nasal and paranasal tumors depends on where your tumor is located and what types of cells are involved. Your healthcare team will work with you to come up with a treatment plan that is best for your tumor. […] The goal of surgery for nasal and paranasal tumors is to remove all of the tumor. The surgeon might also remove some of the tissue around the tumor to make sure all the tumor cells are removed. […] Cancerous nasal and paranasal tumors might need other treatments to control the cancer cells. Options might include: […] Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons or other sources. During radiation therapy, a machine directs beams of energy to specific points on the body to kill the cancer cells there.

• #1 Surgery for Nasal or Paranasal Sinus Cancer | Cancer Council NSW

  https://www.cancercouncil.com.au/head-and-neck-cancer/treatment/surgery/surgery-for-nasal-or-paranasal-sinus-cancer/

  Your doctor may advise you to have surgery for nasal or paranasal sinus cancer if the tumour isn’t too close to your brain or major blood vessels. The type of surgery will depend on where the tumour is and, if you have paranasal sinus cancer, which sinuses are affected. You will often need to have reconstructive surgery as well. […] Different types of surgery for nasal and sinus cancer include: maxillectomy – removes part or all of the upper jaw (maxilla); may include the upper teeth, part of the eye socket and/or the nasal cavity; skull base surgery – also known as a craniofacial resection, this surgery removes part of the nasal cavity or sinuses; often done endoscopically through the nose, but a cut along the side of the nose may be needed; sometimes a neurosurgeon assists with this surgery; orbital exenteration – removes the eye and may also remove tissue around the eye socket; rhinectomy – removes part or all of the nose.

• #1 Treatment for Paranasal Sinus and Nasal Cancer | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/cancer/paranasal-sinus-nasal-cavity-cancer/paranasal-sinus-nasal-cavity-cancer-treatments.html

  The use of high-energy radiation to kill or shrink cancer cells, tumors, and non-cancerous diseases. […] Surgery is commonly used to remove cancers of the paranasal sinus or nasal cavity. Depending on where the cancer is and how far it has spread, a doctor may need to cut out bone or tissue around the cancer. […] If cancer has spread to lymph nodes in the neck, the lymph nodes may be removed (lymph node dissection). […] Because the paranasal sinuses and nasal cavity help in talking and breathing, and are close to the face, patients may need special help adjusting to the side effects of the cancer and its treatment. […] A doctor will consult with several kinds of doctors who can help determine the best treatment. […] Trained medical staff can also help in recovery from treatment. […] Patients may need plastic surgery if a large amount of tissue or bone around the paranasal sinuses or nasal cavity is taken out.

• #1 Nasal & Paranasal Tumors: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24927-nasal-tumors

  Nasal and paranasal tumors begin in your nasal cavity or paranasal sinuses. These tumors may be cancerous or noncancerous. Treatment depends on the situation, but often includes surgery to remove the tumor. Other treatments include radiation therapy and chemotherapy. […] Treatment for a nose tumor depends on several factors, including your medical history, whether the tumor is cancerous and your personal preferences. Healthcare providers typically recommend surgical removal for noncancerous nose tumors. […] For cancerous nasal tumors, the most common approach includes surgery in combination with radiation therapy. […] The main goal of surgery is to remove as much of the nose tumor as possible. If cancer has spread to nearby lymph nodes, a surgeon will remove them as well. […] Your provider may recommend radiation therapy as a stand-alone treatment or in combination with surgery. You might receive radiation therapy before surgery to shrink the tumor. Or you might undergo radiation therapy after surgery to kill any remaining cancer cells. People who cant or dont wish to undergo surgery, can receive radiation therapy without surgery.

• #1 Treatment For Nasal And Paranasal Sinus Cancer

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/treatment

  Your treatment depends on several factors. These include what type of nasal and paranasal sinus cancer you have, how big it is, whether it has spread (the stage) and the grade. It also depends on your general health. […] The main treatments for nasal and paranasal sinus cancer are surgery, radiotherapy, chemotherapy or chemoradiotherapy. You may also have treatment to reduce the symptoms and help you feel better. A team of doctors and other professionals discuss the best treatment and care for you. […] Surgery alone will cure some types of nasal and paranasal sinus cancers, but others will respond better to a combination of treatments. […] The type of surgery you have for nasal and paranasal sinus cancer depends on the position and stage of your cancer. […] Radiotherapy uses high energy x-rays to destroy cancer cells. You usually have a type of external radiotherapy called intensity modulated radiotherapy (IMRT).

• #1 Nasal and paranasal tumors – Care at Mayo Clinic – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nasal-paranasal-tumors/care-at-mayo-clinic/mac-20354139

  Mayo Clinic doctors provide expert, personalized care to those with nasal and paranasal tumors. […] Mayo Clinic doctors use the latest treatments for nasal and paranasal tumors. […] New technology allows Mayo Clinic radiation oncologists to carefully plan and deliver radiation so that cancer cells are killed and healthy tissue nearby is spared. This reduces the risk of side effects during radiation therapy. Radiation oncologists use specialized radiation treatments, such as intensity-modulated radiation therapy and proton therapy, to precisely target tumor cells and reduce the risk of side effects. […] Mayo Clinic surgeons are highly skilled in minimally invasive surgery techniques, including minimally invasive skull base surgery. They also have extensive experience performing complicated reconstructive operations to restore your ability to eat and speak after surgery.

• #1 Nasal & Sinus Cavity Cancer Treatment | Georgia Radiation Therapy

  https://georgiaradiationtherapy.com/nasal-sinus-cavity-cancer/treatment

  External radiation therapy uses a machine outside the body to send radiation toward the cancer. At RCOG, we primarily use intensity modulated radiation therapy (IMRT) to treat nasal and sinus cavity cancer. IMRT is an advanced form of external beam radiation treatment that allows precise targeting of tumor cells with high energy beams of radiation. This precision allows the radiation oncologist to deliver a maximum dose of radiation to the tumor while sparing much of the surrounding tissue. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. Chemo may be given before or after nasal cavity or paranasal sinus surgery and may also be used in combination with radiation therapy. […] Immunotherapy, also called biologic therapy, is treatment with drugs that help a persons own immune system better recognize and kill cancer cells. Currently, there are two FDA-approved immunotherapies for the treatment of nasal cavity or paranasal sinus cancer.

• #1 Chemotherapy for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/treatment/chemotherapy

  Chemotherapy uses anticancer (cytotoxic) drugs to destroy cancer cells. It is sometimes used to treat nasal cavity and paranasal sinus cancer. Your healthcare team will consider your personal needs to plan the drugs, doses and schedules of chemotherapy. You may also receive other treatments. […] Chemotherapy is often combined with radiation therapy to treat nasal cavity and paranasal sinus cancer. This is called chemoradiation. The 2 treatments are given during the same time period. […] Chemotherapy is given for different reasons. You may have chemotherapy or chemoradiation to: destroy cancer cells in the body, shrink a tumour before other treatments such as surgery or radiation therapy (called neoadjuvant chemotherapy), destroy cancer cells left behind after surgery and reduce the risk that the cancer will come back (recur) (called adjuvant chemotherapy), relieve pain or control the symptoms of advanced nasal cavity and paranasal sinus cancer (called palliative chemotherapy), destroy cancer cells in the body if cancer recurs after the first treatment.

• #1

  https://www.americanoncology.com/cancer-we-treat/treatment/paranasal-sinus-and-nasal-cavity-cancer

  Surgery is the treatment of choice in most cases of paranasal sinus and nasal cavity cancer, especially when the cancer is diagnosed at an early stage. […] Radiation therapy involves high-energy particles or rays to kill cancer cells. It is usually combined with surgery or chemotherapy to increase the efficacy of overall treatment. […] Chemotherapy involves drugs to kill cancer cells. Different chemotherapy drugs work during different stages of the cell cycle, and a combination of drugs is usually used to increase treatment efficacy and lower the risk of recurrence. […] Immunotherapy drugs boost the immune system and interfere with these processes, making the cancer cells vulnerable to getting attacked by the immune cells. […] Targeted therapy either blocks the synthesis of these chemicals or prevents the functioning of these chemicals, resulting in the death of cancer cells.

• #1 Chemotherapy for nasal cavity and paranasal sinus cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/treatment/chemotherapy

  Chemotherapy is usually a systemic therapy. This means that the drugs travel through the blood to reach and destroy cancer cells all over the body, including those that may have broken away from the primary tumour in the nasal cavity or paranasal sinus. […] Chemotherapy drugs used to treat nasal cavity and paranasal sinus cancer are: cisplatin (most common drug used), carboplatin, fluorouracil (Adrucil), docetaxel (Taxotere), paclitaxel. […] The most common chemotherapy drug combinations used to treat nasal cavity and paranasal sinus cancer are: cisplatin and fluorouracil, cisplatin and docetaxel, cisplatin and paclitaxel, carboplatin and fluorouracil, carboplatin and paclitaxel. […] Chemotherapy for nasal cavity and paranasal sinus cancers usually takes about 6 months to complete. The drugs are usually given once every 3 or 4 weeks. Each 3- or 4-week period of time is called a cycle. You will likely have 3 or 4 cycles of chemotherapy, and then your healthcare team will do some tests to see if the treatment is working. If it is working, you may have up to 6 cycles of treatment as long as the side effects are not too severe.

• #1 Nasal cavity and paranasal sinus cancers | EBSCO Research Starters

  https://www.ebsco.com/research-starters/health-and-medicine/nasal-cavity-and-paranasal-sinus-cancers

  Radiation therapy may be performed before or after surgery and applied internally or externally. Intensity-modulated radiation therapy (IMRT) is the most commonly used radiation therapy in nasal or paranasal cancers. Induction radiation, which is radiation therapy before surgery, can decrease the size of the tumor and simplify tumor resection. This may save the eye in individuals with advanced-stage cancers. After surgery, it destroys any remaining tumor cells. […] Nasal cavity and paranasal sinus cancers can be treated with chemotherapy either before or after surgery. Chemotherapy before surgery may decrease the size of the tumor to make surgical removal more manageable. Chemotherapy administered after surgery is intended to destroy any remaining cancer cells. Chemotherapy drugs may be given with radiation. Traditional chemotherapy drugs include cisplatin and 5-fluorouracil for paranasal sinus cancers. Vincristine (Oncovin), cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), and cisplatin treat esthesioneuroblastomas. Epidermal growth factor receptor (EGFR) inhibitor drugs are also used to treat nasal cavity and paranasal sinus cancers. These drugs interfere with the growth and division of tumor cells by inhibiting a hormone that encourages their growth. EGFR drugs include cetuximab (Erbitux), gefitinib (Iressa), and erlotinib (Tarceva). Modern research focuses on genetic therapy and drugs that target tumors with TP53 mutations.

• #1 Mayo Clinic Health Library – Nasal and paranasal tumors | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20198269

  Chemotherapy uses strong medicines to kill cancer cells. Chemotherapy may be used after surgery to kill any remaining cells. […] Immunotherapy is a treatment with medicine that helps your body’s immune system kill cancer cells. Your immune system fights off diseases by attacking germs and other cells that shouldn’t be in your body. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65831/

  Treatment options for stage I maxillary sinus tumors include the following: Surgical resection. Postoperative radiation therapy should be considered for close margins (particularly in tumors of the suprastructure). […] Treatment options for stage II maxillary sinus tumors include the following: Surgical resection with high-dose preoperative or postoperative radiation therapy. […] Treatment options for stage III maxillary sinus tumors include the following: Surgical resection with high-dose preoperative or postoperative radiation therapy. Superfractionated preoperative or postoperative radiation therapy (under clinical evaluation). […] Treatment options for stage IV maxillary sinus tumors include the following: High-dose radiation therapy is used because extension to the base of the skull and nasopharynx is a potential, but not absolute, contraindication to surgery.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Patient Information [NCI] | Kaiser Permanente

  https://healthy.kaiserpermanente.org/washington/health-wellness/health-encyclopedia/he.paranasal-sinus-and-nasal-cavity-cancer-treatment-adult-pdq-treatment—patient-information-nci.ncicdr0000258028

  Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] Treatment of stage I paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity: If cancer is in the maxillary sinus, treatment is usually surgery with or without radiation therapy. […] Treatment of stage II paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity: If cancer is in the maxillary sinus, treatment is usually high-dose radiation therapy before or after surgery. […] Treatment of stage III paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of stage IV paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of recurrent paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Health Professional Information [NCI] | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.paranasal-sinus-and-nasal-cavity-cancer-treatment-pdq%C2%AE-treatment-health-professional-information-nci.ncicdr0000062931

  Treatment options for stage II maxillary sinus tumors include the following: Surgical resection with high-dose preoperative or postoperative radiation therapy. […] Treatment options for stage III maxillary sinus tumors include the following: Surgical resection with high-dose preoperative or postoperative radiation therapy. […] Treatment options for stage IV maxillary sinus tumors include the following: High-dose radiation therapy is used because extension to the base of the skull and nasopharynx is a potential, but not absolute, contraindication to surgery. […] Treatment options for recurrent maxillary sinus tumors include the following: After surgery, radiation therapy or craniofacial resection with postoperative radiation therapy.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Patient Information [NCI] – Women’s Health – Associates for Women’s Medicine – Syracuse NY Gynecologist, Gynecology, Obstetrics, OBGYN, OB Physicians, Syracuse New York, Fayetteville, N

  https://www.afwomensmed.com/health-library/hw-view.php?DOCHWID=ncicdr0000258028

  If cancer is in the nasal cavity, treatment may include: Surgery and/or radiation therapy. […] Treatment of recurrent paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] If cancer is in the maxillary sinus, treatment may include: Surgery followed by radiation therapy. […] If cancer is in the nasal cavity, treatment may include: Surgery and/or radiation therapy.

• #1 Nasal Cavity (Nose) and Paranasal Sinus Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/treating.html

  Its important to discuss all treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. […] If the cancer is too advanced to be cured, the goal may be to remove or destroy as much of the cancer as reasonable to help keep the tumor from growing or spreading for as long as possible. Some of the treatments above can also be used as palliative treatment if all the cancer cannot be removed. Palliative treatment is used to relieve symptoms such as pain, but it’s not expected to cure the cancer. […] Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the-art cancer treatment. […] You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors havent mentioned. These methods can include vitamins, herbs, and special diets, or other methods such as acupuncture or massage, to name a few.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65831/

  Treatment options for recurrent maxillary sinus tumors include the following: After surgery, radiation therapy or craniofacial resection with postoperative radiation therapy. After radiation therapy, craniofacial resection if indicated. Chemotherapy should be considered for patients with disease that does not respond to other treatments.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Health Professional Information [NCI] – Sol Wellness and Psychiatry

  https://solwellnessandpsychiatry.com/patient-education/healthwise/?DOCHWID=ncicdr0000062931

  Treatment options for recurrent maxillary sinus tumors include the following: After surgery, radiation therapy or craniofacial resection with postoperative radiation therapy. […] Treatment options for recurrent ethmoid sinus tumors include the following: After limited surgery, craniofacial resection, radiation therapy, or both. […] Treatment options for recurrent nasal cavity tumors include the following: For disease that does not respond to radiation therapy, craniofacial resection.

• #1

  https://fcs.navigatingcare.com/library/paranasalsinus/learn/treatment-of-recurrent-paranasal-sinus-and-nasal-cavity-cancer

  Treatment of recurrent paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] If cancer is in the maxillary sinus, treatment may include: Surgery followed by radiation therapy. Radiation therapy followed by surgery. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy. […] If cancer is in the ethmoid sinus, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy. […] If cancer is in the sphenoid sinus, treatment is the same as for nasopharyngeal cancer and may include radiation therapy with or without chemotherapy. […] If cancer is in the nasal cavity, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy.

• #1

  https://fcs.navigatingcare.com/library/paranasalsinus/learn/treatment-of-recurrent-paranasal-sinus-and-nasal-cavity-cancer

  For inverting papillomas, treatment is usually surgery with or without radiation therapy. […] For melanomas and sarcomas, treatment may include: Surgery. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. […] For midline granulomas, treatment is usually radiation therapy. […] If cancer is in the nasal vestibule, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy.

• #1 Principles and Techniques of Radiotherapy and Chemotherapy for Nasal Cavity and Paranasal Sinus Tumors | Ento Key

  https://entokey.com/principles-and-techniques-of-radiotherapy-and-chemotherapy-for-nasal-cavity-and-paranasal-sinus-tumors/

  Sinonasal malignancies are relatively rare tumors of the head and neck accounting for less than 1% of all malignancies and ~3% of upper respiratory tract tumors. […] A multidisciplinary team approach involving experts in head and neck cancer surgery, radiotherapy, chemotherapy, imaging, and pathology is best suited for managing cases of disease in this region to provide patients with the best chance of cure and optimal quality of life. Primary and adjuvant radiotherapy have essential roles in the overall treatment strategy for tumors in this complex anatomical location. […] The definitive treatment for nasal vestibule tumors is either surgery, primary radiotherapy, or when indicated because of tumor size or positive surgical findings surgery followed by adjuvant radiation therapy. […] For small superficial tumors, standard treatment approaches are surgery or primary radiotherapy, delivered as external beam radiotherapy, brachytherapy, or a combination of the two.

• #1 Nasal and Paranasal Sinus Cancer: Neoadjuvant Chemotherapy and Organ Preservation – The ASCO Post

  https://ascopost.com/news/september-2024/nasal-and-paranasal-sinus-cancer-neoadjuvant-chemotherapy-and-organ-preservation/

  Researchers have found that chemotherapy prior to surgery may reduce the amount of normal tissue that needs to be removed in patients with advanced nasal and paranasal sinus squamous cell carcinoma, according to recent findings presented by Saba et al at the European Society for Medical Oncology (ESMO) Congress 2024 (Abstract 850MO). […] Small single-institution trials investigating receipt of chemotherapy prior to surgery have yielded questionable results on the improvement of organ preservation. […] The researchers discovered that the patients who received chemotherapy prior to surgery had a 50% chance of structure preservation. In contrast, those who had surgery had a 15% chance of preserving both the eye and the base of the skull bone. […] These results support chemotherapy before surgery as an effective intervention to improve the preservation of vital organs, bone, and tissue in patients with nasal and paranasal sinus squamous cell carcinoma, highlighted Dr. Saba. […] We believe future trials will need to test whether modifying the choice of chemotherapy or adding immunotherapy could improve the chance of organ preservation, concluded senior study author Barbara A. Burtness, MD.

• #1 Surgery for Nasal or Paranasal Sinus Cancer | Cancer Council NSW

  https://www.cancercouncil.com.au/head-and-neck-cancer/treatment/surgery/surgery-for-nasal-or-paranasal-sinus-cancer/

  If your nose, or a part of it, is removed, you may need to have an artificial nose (prosthesis) or the nose may be reconstructed using tissue from other parts of your body. The process for completing the prosthetic or reconstructed nose may take several months. Your surgeon will give you more information about the process and how long this is likely to take. A prosthetic eye may also be an option.

• #1 Nasal Cavity and Paranasal Sinus Cancer | Cancer Support Community

  https://www.cancersupportcommunity.org/nasal-cavity-and-paranasal-sinus-cancer

  Endoscopic surgery: uses a narrow instrument called an endoscope, which can often be used to remove tumors from the nose and sinuses without making any cuts to the face. […] Open surgery: For some large tumors and those that cannot be removed with an endoscope, the doctor may need to make a cut in the face to most safely remove your cancer. The doctor will try to keep all surgical cuts in the area of natural shadow lines or skin creases to hide them. […] If you have a tumor that extends to the roof of the mouth, the surgery to remove the tumor may create a hole from the mouth to the nose and/or sinuses. A specialist called a maxillofacial prosthodontist can develop a dental appliance called an obturator, which seals the hole. It acts like an upper denture to replace any missing teeth in the area. […] In cases where the tumor extends through the skull base, or the narrow sheet of bone that separates the nasal cavity from the space containing the brain, your surgeon may work with a neurosurgeon to help most safely remove the tumor.

• #1 Nasal Cavity (Nose) and Paranasal Sinus Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/nasal-cavity-and-paranasal-sinus-cancer/treating.html

  Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision. […] Whether you are thinking about treatment, getting treatment, or not being treated at all, you can still get supportive care to help with pain or other symptoms. […] Some people, especially if the cancer is advanced, might not want to be treated at all. There are many reasons you might decide not to get cancer treatment, but its important to talk to your doctors as you make that decision. Remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms. […] People who have advanced cancer and who are expected to live less than 6 months may want to consider hospice care. Hospice care is designed to provide the best possible quality of life for people who are near the end of life.

• #1 Nasal Cavity (Nose) and Paranasal Sinus Cancer: Staging and Treatment | OncoLink

  https://www.oncolink.org/cancers/head-and-neck/nasal-cavity-nose-and-paranasal-sinus-cancers/nasal-cavity-nose-and-paranasal-sinus-cancer-staging-and-treatment

  Chemotherapy is the use of anti-cancer medications to kill cancer cells. […] Nasal cavity and paranasal sinus cancers may be treated with targeted therapies that focus on specific gene mutations or proteins in the tumor. […] Immunotherapy is the use of a person’s own immune system to kill cancer cells. […] Supportive and palliative treatments are used to lessen symptoms or side effects that you may have. […] You may be offered a clinical trial as part of your treatment plan.

• #1 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/head-and-neck/hp/adult/paranasal-sinus-treatment-pdq

  Except for patients with T1 mucosal carcinomas, the accepted method of treatment is a combination of radiation therapy and surgery. […] For patients with operable tumors, radical surgery is generally performed first to remove the bulk of the tumor and to establish drainage of the affected sinus(es). This is followed by postoperative radiation therapy. […] Radiation therapy must be carried to high doses for any significant probability of permanent control. […] Patients with recurrent disease should consider chemotherapy clinical trials. […] Treatment of tumors of the paranasal sinuses and of the nasal cavity should be planned on an individual basis because of the complexity involved. […] Neoadjuvant chemotherapy as used in clinical trials has been used to shrink tumors and to render them more definitively treatable with either surgery or radiation therapy. […] Chemotherapy for recurrent head and neck squamous cell cancer has shown promise. Chemotherapy may be indicated when there is recurrence in either distant or local disease after primary surgery or radiation therapy, and when there is residual disease after primary treatment.

• #1 Management of Nasal Cavity and Paranasal Sinus Cancers » Radiation Oncology » College of Medicine » University of Florida

  https://radonc.med.ufl.edu/patient-care/information-for-patients/sites-of-treatment/head-neck-cancers/management-of-nasal-cavity-and-paranasal-sinus-cancers/

  The treatment for cancer arising in the nasal cavity and paranasal sinuses is either radiation therapy alone or a combination of surgery combined with adjuvant radiation therapy. The chance of cure is inversely related to the extent of the primary tumor (whether the cancer arises in the nasal cavity or sinuses). […] However, by combining surgery with irradiation, it is possible to use a lower radiation dose, thus lowering the risk of complications such as damage to the optic nerves and brain.

• #1 Nasal and Sinus Cancer Treatments | Northwestern Medicine

  https://www.nm.org/conditions-and-care-areas/cancer-care/head-and-neck-cancers/nasal-and-sinus-cancer/treatments

  Northwestern Medicine offers advanced endoscopic and skull base surgical techniques to remove the tumors of the nose and sinuses in a minimally invasive fashion whenever possible. […] For targeted treatment of the tumors located close to important structures, such as the eye and the brain, Northwestern Medicine offers advanced radiation therapy techniques, including: Stereotactic radiosurgery, Gamma Knife radiosurgery, Proton therapy. […] Our radiation oncologists are specialists in the treatment of tumors located in the sinuses, nasal cavity and the skull base. […] Most importantly, access to highly specialized centers focusing on cancer care such as the Northwestern Medicine Head and Neck Program, has been repeatedly shown to improve survival outcomes for patients with cancer. […] Recognize experts in skull-base surgery, endoscopic surgery, advanced radiation therapy, and medical oncology working together as a team can offer the best prospect of cure. […] Treatments include: Chemotherapy, Gamma Knife Radiosurgery, Intensity Modulated Radiation Therapy, Minimally Invasive Surgery.

• #2 Principles and Techniques of Radiotherapy and Chemotherapy for Nasal Cavity and Paranasal Sinus Tumors | Ento Key

  https://entokey.com/principles-and-techniques-of-radiotherapy-and-chemotherapy-for-nasal-cavity-and-paranasal-sinus-tumors/

  Sinonasal malignancies are relatively rare tumors of the head and neck accounting for less than 1% of all malignancies and ~3% of upper respiratory tract tumors. […] A multidisciplinary team approach involving experts in head and neck cancer surgery, radiotherapy, chemotherapy, imaging, and pathology is best suited for managing cases of disease in this region to provide patients with the best chance of cure and optimal quality of life. Primary and adjuvant radiotherapy have essential roles in the overall treatment strategy for tumors in this complex anatomical location. […] The definitive treatment for nasal vestibule tumors is either surgery, primary radiotherapy, or when indicated because of tumor size or positive surgical findings surgery followed by adjuvant radiation therapy. […] For small superficial tumors, standard treatment approaches are surgery or primary radiotherapy, delivered as external beam radiotherapy, brachytherapy, or a combination of the two.

• #2 About Nasal & Sinus Cancer | University Hospitals

  https://www.uhhospitals.org/services/cancer-services/head-and-neck-cancer/diagnosis-and-treatments/nasal-and-sinus-cancer/about-nasal-and-sinus-cancer

  Paranasal sinus and nasal cavity cancer is a disease in which malignant (cancer) cells form in the tissues of the paranasal sinuses and nasal cavity. […] There are different types of treatment for patients with paranasal sinus and nasal cavity cancer. […] Patients with paranasal sinus and nasal cavity cancer should have their treatment planned by a team of doctors with expertise in treating head and neck cancer. […] The following types of treatment are used: Surgery, Radiation therapy, Chemotherapy. […] After the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

• #2 Treatment Options | Nasal And Paranasal Sinus Cancer

  https://www.cancerresearchuk.org/about-cancer/nasal-sinus-cancer/treatment/options

  A team of health professionals decides what treatment you might need. They also decide what treatment options you have. The most common treatments for nasal and paranasal sinus cancer are: surgery, radiotherapy, chemotherapy. A team of doctors and other professionals discuss the best treatment and care for you. They are called a multidisciplinary team (MDT). Your treatment depends on: the type of nasal and paranasal sinus cancer, where your cancer is, how far it has grown or spread (the stage), your general health and level of fitness. Surgery is a common treatment for nasal cavity and paranasal sinus tumours. The type of operation you have will depend on the position of the cancer and its size. Most surgery is performed under general anaesthetic. During surgery, your surgeon will examine the area around the tumour. They remove a margin of normal tissue. This lowers the risk of the cancer coming back. Radiotherapy on its own can treat some types of nasal cavity and paranasal sinus cancers. This is usually when the cancer hasn’t spread. It will cure most people with small tumours of the nose (nasal cavity). Your doctor may recommend that you have radiotherapy if you have an operation first. This will get rid of any remaining cancer cells and lowers the risk of the cancer coming back. Sometimes radiotherapy is combined with chemotherapy to make the treatment more effective. You might have chemotherapy for any of the following reasons: before or after surgery or radiotherapy, to treat some cancers that have spread to other parts of the body, if your cancer has come back after surgery and radiotherapy, during a course of radiotherapy (chemoradiotherapy) for locally advanced cancer. Targeted cancer drugs work by targeting the differences in cancer cells that help them to grow and survive. Other drugs help the immune system to attack the cancer. They are called immunotherapies. Targeted cancer drugs and immunotherapy are not part of the standard treatment for nasal and paranasal sinus cancer. Surgery won’t cure your cancer if it has already spread to another part of your body. It might help to control the cancer for a time and reduce symptoms. Your doctor may also suggest: surgery and radiotherapy together, radiotherapy alone, chemotherapy alone or with radiotherapy (chemoradiotherapy), newer treatments such as immunotherapy or targeted cancer drugs. Palliative care means: controlling any symptoms you have, such as pain, sickness or breathing problems, giving treatment that can shrink the cancer and control symptoms, supporting you with both physical care and psychological care, ensuring that you have the best possible care in place before going home from hospital.

• #2 Nasal & Paranasal Tumors: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24927-nasal-tumors

  Nasal and paranasal tumors begin in your nasal cavity or paranasal sinuses. These tumors may be cancerous or noncancerous. Treatment depends on the situation, but often includes surgery to remove the tumor. Other treatments include radiation therapy and chemotherapy. […] Treatment for a nose tumor depends on several factors, including your medical history, whether the tumor is cancerous and your personal preferences. Healthcare providers typically recommend surgical removal for noncancerous nose tumors. […] For cancerous nasal tumors, the most common approach includes surgery in combination with radiation therapy. […] The main goal of surgery is to remove as much of the nose tumor as possible. If cancer has spread to nearby lymph nodes, a surgeon will remove them as well. […] Your provider may recommend radiation therapy as a stand-alone treatment or in combination with surgery. You might receive radiation therapy before surgery to shrink the tumor. Or you might undergo radiation therapy after surgery to kill any remaining cancer cells. People who cant or dont wish to undergo surgery, can receive radiation therapy without surgery.

• #2 Surgery for Sinonasal Cancer | NYU Langone Health

  https://nyulangone.org/conditions/sinonasal-cancer/treatments/surgery-for-sinonasal-cancer

  NYU Langone doctors perform surgery to remove most types of sinonasal cancer. The type of surgery used depends on the location of the tumor and whether it has spread. […] Surgery is often followed by radiation therapy, which uses energy beams to destroy any remaining cancer cells. […] Sinonasal lymphoma is best treated with chemotherapy with or without radiation therapy. […] After your doctor performs a physical exam, nasal endoscopy, and imaging tests such as CT and MRI scans, he or she can determine the extent of the tumor and recommend the appropriate surgery for you. Approaches include endoscopic surgery and open surgery. […] Some sinonasal tumors can be removed using an endoscope, a thin, lighted tube with a lens at the tip that transmits images to a monitor. […] The cancer is removed using small surgical tools inserted through the nostrils.

• #2 Treatments for nasal cavity cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/nasal-and-paranasal-sinus/treatment/nasal-cavity

  Radiation therapy may also be given after surgery to lower the chance of the cancer coming back (recurring). It may be offered before surgery if it is likely that cancer cells will be in the tissue around the tumour that will be removed by surgery (called a positive surgical margin). […] If the tumour is on the septum and is smaller than 1.5 cm, it may be treated with brachytherapy. Brachytherapy is a form of radiation therapy that places a radioactive material (called a radioactive isotope) directly into, or very close to, the tumour. […] Chemoradiation is a treatment that gives chemotherapy along with radiation therapy. The chemotherapy drug most often used is cisplatin. It may be given after surgery if there are cancer cells in the tissue around the removed tumour. […] Surgery is the main treatment for stages 3 and 4 nasal cavity cancer. The type of surgery done depends on where the tumour is in the nasal cavity and whether or not it has grown into nearby bone. Reconstructive surgery is also done to help restore the form and function of the nose.

• #2 Mayo Clinic Health Library – Nasal and paranasal tumors | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20198269

  Most nasal and paranasal tumors are treated with surgery to remove the tumor. Treatment for nasal and paranasal tumors depends on where your tumor is located and what types of cells are involved. Your healthcare team will work with you to come up with a treatment plan that is best for your tumor. […] The goal of surgery for nasal and paranasal tumors is to remove all of the tumor. The surgeon might also remove some of the tissue around the tumor to make sure all the tumor cells are removed. […] Cancerous nasal and paranasal tumors might need other treatments to control the cancer cells. Options might include: […] Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons or other sources. During radiation therapy, a machine directs beams of energy to specific points on the body to kill the cancer cells there.

• #2 Nasal and Sinus Cancer Treatments | Northwestern Medicine

  https://www.nm.org/conditions-and-care-areas/cancer-care/head-and-neck-cancers/nasal-and-sinus-cancer/treatments

  Northwestern Medicine offers advanced endoscopic and skull base surgical techniques to remove the tumors of the nose and sinuses in a minimally invasive fashion whenever possible. […] For targeted treatment of the tumors located close to important structures, such as the eye and the brain, Northwestern Medicine offers advanced radiation therapy techniques, including: Stereotactic radiosurgery, Gamma Knife radiosurgery, Proton therapy. […] Our radiation oncologists are specialists in the treatment of tumors located in the sinuses, nasal cavity and the skull base. […] Most importantly, access to highly specialized centers focusing on cancer care such as the Northwestern Medicine Head and Neck Program, has been repeatedly shown to improve survival outcomes for patients with cancer. […] Recognize experts in skull-base surgery, endoscopic surgery, advanced radiation therapy, and medical oncology working together as a team can offer the best prospect of cure. […] Treatments include: Chemotherapy, Gamma Knife Radiosurgery, Intensity Modulated Radiation Therapy, Minimally Invasive Surgery.

• #2 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Health Professional Information [NCI] | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.paranasal-sinus-and-nasal-cavity-cancer-treatment-pdq%C2%AE-treatment-health-professional-information-nci.ncicdr0000062931

  Except for patients with T1 mucosal carcinomas, the accepted method of treatment is a combination of radiation therapy and surgery. […] For patients with operable tumors, radical surgery is generally performed first to remove the bulk of the tumor and to establish drainage of the affected sinus(es). This is followed by postoperative radiation therapy. […] Surgical exploration may be required to determine operability. […] Radiation therapy must be carried to high doses for any significant probability of permanent control. […] Patients with recurrent disease should consider chemotherapy clinical trials. […] Treatment of tumors of the paranasal sinuses and of the nasal cavity should be planned on an individual basis because of the complexity involved. […] Treatment options for stage I maxillary sinus tumors include the following: Surgical resection. Postoperative radiation therapy should be considered for close margins (particularly in tumors of the suprastructure).

• #2 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK66003/

  Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] New types of treatment are being tested in clinical trials. […] Treatment for paranasal sinus and nasal cavity cancer may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Follow-up tests may be needed. […] Treatment of stage I paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of stage II paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of stage III paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of stage IV paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] Treatment of recurrent paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity.

• #2 Nasal Cavity (Nose) and Paranasal Sinus Cancer: Staging and Treatment | OncoLink

  https://www.oncolink.org/cancers/head-and-neck/nasal-cavity-nose-and-paranasal-sinus-cancers/nasal-cavity-nose-and-paranasal-sinus-cancer-staging-and-treatment

  Chemotherapy is the use of anti-cancer medications to kill cancer cells. […] Nasal cavity and paranasal sinus cancers may be treated with targeted therapies that focus on specific gene mutations or proteins in the tumor. […] Immunotherapy is the use of a person’s own immune system to kill cancer cells. […] Supportive and palliative treatments are used to lessen symptoms or side effects that you may have. […] You may be offered a clinical trial as part of your treatment plan.

• #2 Nasal and sinus cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/head-and-neck-cancer/nasal-and-sinus-cancer

  Chemotherapy uses anti-cancer drugs to destroy cancer cells. Chemotherapy may be used if a nasal and sinus cancer has spread or come back after previous treatment. […] Immunotherapies are treatments that use the immune system to find and attack cancer cells. An immunotherapy drug may be used to treat some nasal and sinus cancers in certain situations.

• #2 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Patient Information [NCI] – Women’s Health – Associates for Women’s Medicine – Syracuse NY Gynecologist, Gynecology, Obstetrics, OBGYN, OB Physicians, Syracuse New York, Fayetteville, N

  https://www.afwomensmed.com/health-library/hw-view.php?DOCHWID=ncicdr0000258028

  Patients may want to think about taking part in a clinical trial. […] Treatment of stage I paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity: If cancer is in the maxillary sinus, treatment is usually surgery with or without radiation therapy. […] If cancer is in the ethmoid sinus, treatment is usually radiation therapy and/or surgery. […] If cancer is in the sphenoid sinus, treatment is the same as for nasopharyngeal cancer, usually radiation therapy. […] If cancer is in the nasal cavity, treatment is usually surgery and/or radiation therapy. […] Treatment of stage II paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity: If cancer is in the maxillary sinus, treatment is usually high-dose radiation therapy before or after surgery.

• #2 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®): Treatment – Patient Information [NCI] – Women’s Health – Associates for Women’s Medicine – Syracuse NY Gynecologist, Gynecology, Obstetrics, OBGYN, OB Physicians, Syracuse New York, Fayetteville, N

  https://www.afwomensmed.com/health-library/hw-view.php?DOCHWID=ncicdr0000258028

  If cancer is in the ethmoid sinus, treatment is usually radiation therapy and/or surgery. […] If cancer is in the nasal cavity, treatment is usually surgery and/or radiation therapy. […] Treatment of stage III paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] If cancer is in the maxillary sinus, treatment may include: High-dose radiation therapy before or after surgery. […] If cancer is in the ethmoid sinus, treatment may include: Surgery followed by radiation therapy. […] If cancer is in the nasal cavity, treatment may include: Surgery and/or radiation therapy. […] Treatment of stage IV paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] If cancer is in the maxillary sinus, treatment may include: High-dose radiation therapy with or without surgery.

• #2

  https://fcs.navigatingcare.com/library/paranasalsinus/learn/treatment-of-recurrent-paranasal-sinus-and-nasal-cavity-cancer

  Treatment of recurrent paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity. […] If cancer is in the maxillary sinus, treatment may include: Surgery followed by radiation therapy. Radiation therapy followed by surgery. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy. […] If cancer is in the ethmoid sinus, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy. […] If cancer is in the sphenoid sinus, treatment is the same as for nasopharyngeal cancer and may include radiation therapy with or without chemotherapy. […] If cancer is in the nasal cavity, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy.

• #2

  https://fcs.navigatingcare.com/library/paranasalsinus/learn/treatment-of-recurrent-paranasal-sinus-and-nasal-cavity-cancer

  For inverting papillomas, treatment is usually surgery with or without radiation therapy. […] For melanomas and sarcomas, treatment may include: Surgery. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. […] For midline granulomas, treatment is usually radiation therapy. […] If cancer is in the nasal vestibule, treatment may include: Surgery and/or radiation therapy. Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life. A clinical trial of chemotherapy.

• #2 Nasal and Paranasal Sinus Cancer: Neoadjuvant Chemotherapy and Organ Preservation – The ASCO Post

  https://ascopost.com/news/september-2024/nasal-and-paranasal-sinus-cancer-neoadjuvant-chemotherapy-and-organ-preservation/

  Researchers have found that chemotherapy prior to surgery may reduce the amount of normal tissue that needs to be removed in patients with advanced nasal and paranasal sinus squamous cell carcinoma, according to recent findings presented by Saba et al at the European Society for Medical Oncology (ESMO) Congress 2024 (Abstract 850MO). […] Small single-institution trials investigating receipt of chemotherapy prior to surgery have yielded questionable results on the improvement of organ preservation. […] The researchers discovered that the patients who received chemotherapy prior to surgery had a 50% chance of structure preservation. In contrast, those who had surgery had a 15% chance of preserving both the eye and the base of the skull bone. […] These results support chemotherapy before surgery as an effective intervention to improve the preservation of vital organs, bone, and tissue in patients with nasal and paranasal sinus squamous cell carcinoma, highlighted Dr. Saba. […] We believe future trials will need to test whether modifying the choice of chemotherapy or adding immunotherapy could improve the chance of organ preservation, concluded senior study author Barbara A. Burtness, MD.

• #2 Malignant Tumors of the Nasal Cavity Treatment & Management: Medical Therapy, Surgical Therapy, Follow-up

  https://emedicine.medscape.com/article/846995-treatment

  Wide resection of tumors of the nasal cavity and paranasal sinuses can result in facial disfigurement and speech and swallowing difficulties. The main goals of postsurgical rehabilitation of these massive multilayered defects are primary wound healing, preservation or reconstruction of the facial contour, and restoration of oronasal separation, thus facilitating speech and swallowing and separation of the nasal cavity from the cranial cavity.

• #2 Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65831/

  This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of adult paranasal sinus and nasal cavity cancer. It is intended as a resource to inform and assist clinicians in the care of their patients. It does not provide formal guidelines or recommendations for making health care decisions. […] Except for patients with T1 mucosal carcinomas, the accepted method of treatment is a combination of radiation therapy and surgery. The incidence of lymph node metastases is generally low (approximately 20% of cases). Thus, routine radical neck dissection or elective neck radiation therapy is recommended only for patients presenting with positive nodes. […] For patients with operable tumors, radical surgery is generally performed first to remove the bulk of the tumor and to establish drainage of the affected sinus(es). This is followed by postoperative radiation therapy. Some institutions continue to give a full dose of radiation therapy preoperatively for all patients with stage II and stage III tumors and operate 4 to 6 weeks later.

• #2 Cancer of the nose: Facts about nasal cavity and paranasal sinus cancer | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/what-is-nose-cancer.h00-159619434.html

  Some patients can undergo minimally invasive surgery to speed up recovery time and reduce side effects. […] We have pioneered minimally invasive surgery for these types of cancer, he says. […] The two structures closest to the sinuses that can be damaged during radiation are the eye and the brain. MD Anderson treats sinus cancers with proton therapy, which allows for more efficient targeting of the tumor. […] The goal is to eradicate the cancer and protect the eye and brain, says Hanna. Proton therapy, together with minimally invasive surgery, has revolutionized the ability to protect and preserve these precious structures. […] We just finished a clinical trial that looked at the treatment approach of starting with chemotherapy to shrink the tumor with two goals: organ preservation (eyes and brain) and optimizing subsequent treatment.

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