Gorączka doliny
Objawy

Gorączka doliny (kokcydioidomikoza) jest infekcją wywołaną przez grzyby Coccidioides immitis lub C. posadasii, przenoszoną drogą inhalacyjną zarodników z gleby południowo-zachodnich USA. Okres inkubacji wynosi 5-21 dni, a u około 60% zakażonych przebiega bezobjawowo lub z łagodnymi objawami grypopodobnymi. U pozostałych pacjentów pojawiają się objawy takie jak gorączka, kaszel, duszność, bóle stawów i charakterystyczny rumień guzowaty, tworzący triadę „pustynnego reumatyzmu”. Przebieg choroby jest zróżnicowany – u większości ustępuje samoistnie w ciągu kilku tygodni do miesięcy, jednak u 5-10% rozwijają się przewlekłe zmiany płucne, takie jak guzki (2,5-3,8 cm), jamy (kawerny) oraz włóknienie, a u około 1% dochodzi do rozsianej postaci z zajęciem skóry, kości, opon mózgowo-rdzeniowych i innych narządów. Najcięższym powikłaniem jest kokcydioidalne zapalenie opon mózgowo-rdzeniowych, które może być śmiertelne bez leczenia.

Gorączka doliny – definicja i wprowadzenie

Gorączka doliny (ang. Valley fever), znana również jako kokcydioidomikoza, jest chorobą zakaźną wywoływaną przez grzyby z rodzaju Coccidioides (Coccidioides immitis lub Coccidioides posadasii), które bytują w glebie, głównie w południowo-zachodnich regionach Stanów Zjednoczonych. Do zakażenia dochodzi poprzez wdychanie zarodników grzyba, które przedostają się do płuc.12 Jest to pierwotna forma kokcydioidomikozy, która może rozwinąć się w postać przewlekłą lub rozsianą.3

Objawy początkowe gorączki doliny

Szacuje się, że około 60% osób zakażonych grzybem Coccidioides nie rozwija żadnych objawów lub ma jedynie łagodne objawy grypopodobne i nie zgłasza się do lekarza.45 U osób, które doświadczają objawów, pojawiają się one zwykle po 1-3 tygodniach od ekspozycji na zarodniki grzyba.67 Okres inkubacji (czas od kontaktu z grzybem do wystąpienia objawów) wynosi zazwyczaj 5-21 dni.8

Najczęstsze początkowe objawy gorączki doliny to:91011

  • Zmęczenie (osłabienie)
  • Kaszel (suchy lub z odkrztuszaniem plwociny, czasem z krwią)
  • Gorączka
  • Duszność
  • Ból w klatce piersiowej (o różnym nasileniu)
  • Bóle głowy
  • Dreszcze
  • Nocne poty
  • Bóle mięśni i stawów (szczególnie kostek i kolan)
  • Czerwona, plamista wysypka, głównie na dolnych częściach nóg, ale czasem również na klatce piersiowej, ramionach i plecach
  • Utrata apetytu
  • Obrzęk kostek, stóp i nóg

121314

Charakterystyczna triada objawów, nazywana „pustynnym reumatyzmem” (ang. desert rheumatism), obejmuje gorączkę, bolesne czerwone guzki podskórne (rumień guzowaty, łac. erythema nodosum) oraz ból i sztywność stawów, szczególnie stawów skokowych i kolanowych.1516 Guzki rumienia guzowatego są bolesne, lekko uniesione i czerwone, zazwyczaj pojawiają się na goleniach lub przedramionach.17

Przebieg początkowej fazy choroby

Przebieg gorączki doliny jest bardzo zróżnicowany i zależy od kilku czynników, w tym ogólnego stanu zdrowia pacjenta oraz ilości wdychanych zarodników grzyba.18 U większości osób choroba przechodzi samoistnie po kilku tygodniach lub miesiącach, bez konieczności specjalistycznego leczenia.1920

Czas trwania objawów zależy od nasilenia infekcji. Niektóre przypadki mogą trwać kilka miesięcy, a nawet ponad rok do całkowitego ustąpienia.21 Pacjenci często skarżą się na utrzymujące się miesiącami zmęczenie i bóle stawów.2223

Przewlekła kokcydioidomikoza płucna

Jeśli początkowa infekcja nie zostanie całkowicie wyleczona, może rozwinąć się w przewlekłą formę zapalenia płuc, zwaną przewlekłą kokcydioidomikozą płucną. To powikłanie występuje najczęściej u osób z osłabionym układem odpornościowym.2425

Objawy przewlekłej kokcydioidomikozy płucnej obejmują:262728

  • Przewlekły kaszel
  • Odkrztuszanie krwi (krwioplucie)
  • Utrata masy ciała
  • Ból w klatce piersiowej
  • Duszność
  • Gorączka o niskim stopniu

Powikłania płucne

U około 5-10% pacjentów z gorączką doliny rozwijają się poważne lub długotrwałe problemy w płucach.2930 Mogą one obejmować:

  • Guzki płucne – są wynikiem zapalenia płuc spowodowanego gorączką doliny. Guzki to małe, resztkowe ogniska infekcji, które zwykle pojawiają się jako pojedyncze zmiany o średnicy od 2,5 do 3,8 cm. Mogą wystąpić zarówno u pacjentów bezobjawowych, jak i objawowych. Około 5-7% pacjentów z zapaleniem płuc wywoływanym przez grzyb Coccidioides rozwija wyraźnie odgraniczone, pojedyncze guzki.3132
  • Jamy (kawerny) – występują u około 5% pacjentów z kokcydioidomikozą płucną. Typowa jama kokcydioidalna ma cienkie ściany i jest pojedyncza. Jamy kokcydioidalne są zwykle bezobjawowe i około 50% z nich znika w ciągu 2 lat od wystąpienia. Jama może utrzymywać się przez lata z niewielkimi zmianami. Około jedna trzecia pacjentów z jamami może doświadczać krwioplucia, które jest często nawracające, ale zazwyczaj nie zagraża życiu.33
  • Włóknienie płuc (zwłóknienie) – w przewlekłej postaci prowadzi do utraty objętości płuc, zwłóknienia (bliznowacenia) i stanu zapalnego, co jest uważane za poważne powikłanie choroby.34
  • Wysięk opłucnowy lub ropniak opłucnej – nagromadzenie płynu lub ropy w przestrzeni opłucnowej.35
  • Zespół ostrej niewydolności oddechowej (ARDS).36
  • Pęknięte pęcherze z płynem lub powietrzem w płucach (hydropneumothorax).37

Rozsiana kokcydioidomikoza

Najpoważniejszą formą choroby jest rozsiana kokcydioidomikoza (disseminated coccidioidomycosis), która występuje rzadko – u około 1% zakażonych osób.3839 Pojawia się, gdy infekcja rozprzestrzenia się poza płuca do innych części ciała poprzez krwiobieg.4041

Najczęściej zajmowane obszary w rozsianej kokcydioidomikozie to:4243

  • Skóra
  • Kości
  • Stawy
  • Wątroba
  • Mózg
  • Serce
  • Opony mózgowo-rdzeniowe (otoczki chroniące mózg i rdzeń kręgowy)

Objawy rozsianej choroby

Objawy rozsianej kokcydioidomikozy zależą od zajętych części ciała i mogą obejmować:444546

  • Zmiany skórne – guzki, owrzodzenia i zmiany skórne, poważniejsze niż wysypka występująca czasem przy początkowej infekcji. Zmiany skórne w gorączce doliny są często oznaką rozsianej choroby. W przypadku bardziej rozpowszechnionej infekcji, rany lub zmiany skórne najczęściej występują na twarzy.47
  • Zmiany kostne – bolesne zmiany w czaszce, kręgosłupie lub innych kościach.48
  • Bolesne, opuchnięte stawy, szczególnie kolana lub kostki.49
  • Zapalenie opon mózgowo-rdzeniowych – infekcja błon i płynu otaczającego mózg i rdzeń kręgowy, objawiająca się silnymi bólami głowy, niewyraźnym widzeniem, nadwrażliwością na światło, sztywnością karku, zmianami słuchu i dezorientacją.5051
  • Zmiany w stanie psychicznym.52
  • Powiększone lub drenujące węzły chłonne.53
  • Bardziej nasilone objawy płucne.54
  • Utrata masy ciała.55

Czynniki ryzyka ciężkiego przebiegu choroby

Choroba z większym prawdopodobieństwem rozprzestrzenia się do innych obszarów ciała u osób o osłabionym układzie odpornościowym. Do grupy podwyższonego ryzyka należą:565758

  • Kobiety w ciąży
  • Osoby zakażone HIV
  • Osoby przyjmujące leki osłabiające układ odpornościowy
  • Osoby z cukrzycą
  • Osoby starsze, zwłaszcza powyżej 60 roku życia59
  • Osoby po przeszczepach narządów60
  • Osoby rasy czarnej lub pochodzenia filipińskiego61

Powikłania i rokowanie

W większości przypadków osoby z infekcją gorączki doliny wracają do zdrowia bez żadnych długoterminowych skutków.62 Małej liczbie osób rozwijają się trwające kilka lat infekcje płuc.63

Powikłania gorączki doliny są rzadkie, zaledwie około 1% osób objawowych rozwija ciężką postać choroby.64 Mniej niż 1% osób zdiagnozowanych z gorączką doliny umiera z jej powodu.65

Najpoważniejszym powikłaniem jest kokcydioidalne zapalenie opon mózgowo-rdzeniowych, które występuje u 30-50% rozsianej infekcji i może być śmiertelne, jeśli nie jest leczone.6667

Przewlekłe konsekwencje

Długoterminowe konsekwencje mogą obejmować:68

  • Tworzenie jam lub guzków w klatce piersiowej
  • Ropnie grzybicze
  • Przewlekłe zmęczenie i bóle stawów trwające miesiącami69
  • Bliznowacenie płuc, które może utrzymywać się przez całe życie70

U niektórych osób choroba może nawracać lub stać się przewlekła. Pierwsza infekcja gorączki doliny często daje dożywotnią odporność, jednak choroba może zostać reaktywowana lub możliwe jest ponowne zakażenie, jeśli układ odpornościowy jest znacznie osłabiony.7172

Przebieg czasowy choroby

Podsumowując przebieg czasowy gorączki doliny:737475

  1. Okres inkubacji: 1-3 tygodnie (zazwyczaj 7-21 dni) od ekspozycji na zarodniki grzyba.
  2. Ostra faza: Objawy początkowe (grypopodobne) trwają zwykle od kilku tygodni do kilku miesięcy.
  3. Faza przewlekła: U 5-10% pacjentów rozwijają się przewlekłe problemy płucne.
  4. Faza rozsiana: U około 1% pacjentów infekcja rozprzestrzenia się poza płuca do innych części ciała.
Faza choroby Czas wystąpienia Najczęstsze objawy Częstość występowania
Bezobjawowa Brak objawów 60% zakażonych
Ostra (pierwotna) 1-3 tygodnie po ekspozycji Zmęczenie, kaszel, gorączka, ból w klatce piersiowej, bóle stawów, wysypka 40% zakażonych
Przewlekła płucna Tygodnie do miesięcy po pierwotnej infekcji Przewlekły kaszel, krwioplucie, utrata masy ciała, ból w klatce piersiowej 5-10% zakażonych
Rozsiana Tygodnie do lat po pierwotnej infekcji Zmiany skórne, bóle kostne i stawowe, objawy neurologiczne Około 1% zakażonych

Czas trwania gorączki doliny jest bardzo zróżnicowany – od kilku tygodni do kilku miesięcy w przypadkach niepowikłanych, a w przypadkach przewlekłych lub rozsianych może trwać wiele lat.76 Przewlekłe formy gorączki doliny mogą trwać latami, z naprzemiennymi okresami zaostrzeń i remisji.77

Kolejne rozdziały

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  1. 12.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #2 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    Valley fever is an infection that occurs when the spores of the fungus Coccidioides immitis or Coccidioides posadasii enter your body through the lungs. […] Most people with an infection by this fungus never have symptoms. Others may have cold- or flu-like symptoms or symptoms of pneumonia. If symptoms occur, they typically start 5 to 21 days after exposure to the fungus. […] Common symptoms include: Ankle, feet, and leg swelling, Chest pain (can vary from mild to severe), Cough, possibly producing blood-tinged phlegm (sputum), Fever and night sweats, Headache, Joint stiffness and pain or muscle aches, Loss of appetite, Painful, red lumps on lower legs (erythema nodosum). […] Rarely, the infection spreads from the lungs through the bloodstream to involve the skin, bones, joints, lymph nodes, and central nervous system or other organs. This spread is called disseminated coccidioidomycosis.
  • #3 Valley fever // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/valley-fever
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #4 Valley Fever In People | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms.
  • #5 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. […] When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley fever may last years, with a waxing and waning course. […] Symptoms usually develop within 7-28 days after exposure.
  • #6 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #7 Symptoms of Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/signs-symptoms/index.html
    Valley fever is a fungal lung infection and causes symptoms of pneumonia. […] Symptoms usually last for a few weeks to a few months. […] Rarely, Valley fever can cause severe lung infections or infections throughout the body. […] Symptoms include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Symptoms of Valley fever may appear between 1 and 3 weeks after a person breathes in the fungal spores. […] Symptoms usually last for a few weeks to a few months. However, some patients have symptoms that last longer than this, especially if the infection becomes severe. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body.
  • #8 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    Valley fever is an infection that occurs when the spores of the fungus Coccidioides immitis or Coccidioides posadasii enter your body through the lungs. […] Most people with an infection by this fungus never have symptoms. Others may have cold- or flu-like symptoms or symptoms of pneumonia. If symptoms occur, they typically start 5 to 21 days after exposure to the fungus. […] Common symptoms include: Ankle, feet, and leg swelling, Chest pain (can vary from mild to severe), Cough, possibly producing blood-tinged phlegm (sputum), Fever and night sweats, Headache, Joint stiffness and pain or muscle aches, Loss of appetite, Painful, red lumps on lower legs (erythema nodosum). […] Rarely, the infection spreads from the lungs through the bloodstream to involve the skin, bones, joints, lymph nodes, and central nervous system or other organs. This spread is called disseminated coccidioidomycosis.
  • #9 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    Symptoms of Valley fever include fatigue, fever, cough, shortness of breath, headache, muscle or joint pain and rash. […] Symptoms of Valley fever are usually mild or flu-like, though most people with Valley fever have no symptoms. Chronic pulmonary coccidioidomycosis causes additional symptoms like coughing up blood, weight loss and chest pain. […] Valley fever is the earliest stage of a Coccidioides infection. People with this condition often have no symptoms or flu-like symptoms, but it can sometimes progress to more serious stages of coccidioidomycosis. […] In many cases, Valley fever doesn’t cause any symptoms. If you do have symptoms of Valley fever, they might include: Fatigue, Fever, Night sweats, Cough, Shortness of breath (dyspnea), Headache, Muscle aches and joint pain, Erythema nodosum rash.
  • #10 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #11 About Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/about/index.html
    Valley fever causes typical lung infection symptoms like cough and fever. […] Some people who are exposed to the fungus never have symptoms. Other people may have symptoms that include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body. This includes skin, bones, joints, or brain (meningitis).
  • #12 Valley Fever In People | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms.
  • #13 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    Valley fever is an infection that occurs when the spores of the fungus Coccidioides immitis or Coccidioides posadasii enter your body through the lungs. […] Most people with an infection by this fungus never have symptoms. Others may have cold- or flu-like symptoms or symptoms of pneumonia. If symptoms occur, they typically start 5 to 21 days after exposure to the fungus. […] Common symptoms include: Ankle, feet, and leg swelling, Chest pain (can vary from mild to severe), Cough, possibly producing blood-tinged phlegm (sputum), Fever and night sweats, Headache, Joint stiffness and pain or muscle aches, Loss of appetite, Painful, red lumps on lower legs (erythema nodosum). […] Rarely, the infection spreads from the lungs through the bloodstream to involve the skin, bones, joints, lymph nodes, and central nervous system or other organs. This spread is called disseminated coccidioidomycosis.
  • #14 Valley Fever: Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/a-to-z-guides/valley-fever
    Valley fever is the first stage of this fungal infection. Most people dont get sick, but you may experience flu-like symptoms including fever and chills. […] When symptoms appear, they usually go away on their own; however valley fever can bring on flu-like symptoms including fever and chills. […] Six out of every 10 people who get infected with valley fever will have no symptoms. Their bodies will fight off the infection. But for others, signs of valley fever usually show up 1 to 3 weeks after the fungus gets into your lungs. You might have: Fever, Chest pains, Cough, Chills, Night sweats, Headaches, Fatigue, Joint aches, A red, spotty rash, usually on the lower legs, Trouble breathing, Weight loss, Muscle pain. […] If symptoms dont improve on their own or you dont get treatment, valley fever may develop into a long-term type of pneumonia. This mainly happens in people whose immune systems are weak. The symptoms include fever, unexplained weight loss, chest pains, and coughing up mucus with blood in it.
  • #15 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #16 Coccidioidomycosis – Wikipedia
    https://en.wikipedia.org/wiki/Coccidioidomycosis
    Coccidioidomycosis is a common cause of community-acquired pneumonia in the endemic areas of the United States. Infections usually occur due to inhalation of the arthroconidial spores after soil disruption. The disease is not contagious. In some cases, the infection may recur or become chronic. […] After Coccidioides infection, coccidioidomycosis begins with Valley fever, which is its initial acute form. Valley fever may progress to the chronic form and then to disseminated coccidioidomycosis. […] An estimated 60% of people infected with the fungi responsible for coccidioidomycosis have minimal to no symptoms, while 40% will have a range of possible clinical symptoms. Of those who do develop symptoms, the primary infection is most often respiratory, with symptoms resembling bronchitis or pneumonia that resolve over a matter of a few weeks. Notable coccidioidomycosis signs and symptoms include a profound feeling of tiredness, loss of smell and taste, fever, cough, headaches, rash, muscle pain, and joint pain. Fatigue can persist for many months after initial infection. The classic triad of coccidioidomycosis known as „desert rheumatism” includes the combination of fever, joint pains, and erythema nodosum.
  • #17 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. […] When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley fever may last years, with a waxing and waning course. […] Symptoms usually develop within 7-28 days after exposure.
  • #18 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #19 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    In most cases, people with Valley fever infections recover without any long-term effects. A small number of people develop ongoing lung infections that may take several years to resolve. Less than 1% of people diagnosed with Valley fever die from it. […] Symptoms of Valley fever usually go away on their own after a few weeks or months. […] A small number of people can have ongoing disease in their lungs. If it goes on for a long time, it’s usually called chronic pulmonary coccidioidomycosis instead of Valley fever. This may be symptomless or cause symptoms like: Chronic cough, Coughing up blood (hemoptysis), Weight loss, Chest pain, Shortness of breath (dyspnea).
  • #20 Valley Fever Symptoms | Valley Children’s Healthcare
    https://www.valleychildrens.org/services/infectious-disease/conditions-we-treat/valley-fever-symptoms
    Valley fever can start with common symptoms such as fever, cough, chest pain and headaches, and can include other symptoms such as muscle aches, tiredness, joint pain, appetite loss or unusual rashes on the torso, arms and legs. […] The symptoms may look like influenza or pneumonia (lung infection). Most people do well and recover from Valley fever without any specific treatment. […] In more severe cases, Valley fever can develop into chronic pneumonia or meningitis (brain infection). It can also infect bones, joints, skin or other organs. These cases in general will need specific treatments as well as long-term follow-ups.
  • #21 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. […] When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley fever may last years, with a waxing and waning course. […] Symptoms usually develop within 7-28 days after exposure.
  • #22 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    Valley fever is the initial form of coccidioidomycosis infection. This initial, acute illness can develop into a more serious disease, including chronic and disseminated coccidioidomycosis. […] The initial, or acute, form of coccidioidomycosis is often mild, with few or no symptoms. Signs and symptoms occur one to three weeks after exposure. They tend to be similar to flu symptoms. Symptoms can range from minor to severe, including: Fever, Cough, Tiredness, Shortness of breath, Headache, Chills, Night sweats, Joint aches and muscle soreness, Red, spotty rash, mainly on lower legs but sometimes on the chest, arms and back. […] If you develop symptoms, especially severe ones, the course of the disease is highly variable. It can take months to fully recover. Fatigue and joint aches can last even longer. The disease’s severity depends on several factors, including your overall health and the number of fungus spores you inhale.
  • #23 Valley Fever Testing You Can Trust – MiraVista Diagnostics
    https://miravistalabs.com/clinical-resources/valley-fever-testing/
    Valley Fever is the common name for a fungal infection known as coccidioidomycosis. […] Most cases have no symptoms (which is why diagnosis can be difficult) while others may take months and even sometimes over a year to manifest. Those diagnosed with Valley Fever frequently complain of fatigue and joint aches that can last for months. The chronic forms of Valley Fever may last years. […] Patients are commonly misdiagnosed as pneumonia, as there are several similar symptoms. Most patients report flu-like symptoms that usually go away after a few weeks. Other symptoms include: Fatigue, Fever, Headache, Cough, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs.
  • #24 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #25 Valley fever // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/valley-fever
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] Signs and symptoms include: Low-grade fever, Weight loss, Cough, Chest pain, Blood-tinged sputum (matter discharged during coughing), Nodules in the lungs. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #26 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    In most cases, people with Valley fever infections recover without any long-term effects. A small number of people develop ongoing lung infections that may take several years to resolve. Less than 1% of people diagnosed with Valley fever die from it. […] Symptoms of Valley fever usually go away on their own after a few weeks or months. […] A small number of people can have ongoing disease in their lungs. If it goes on for a long time, it’s usually called chronic pulmonary coccidioidomycosis instead of Valley fever. This may be symptomless or cause symptoms like: Chronic cough, Coughing up blood (hemoptysis), Weight loss, Chest pain, Shortness of breath (dyspnea).
  • #27 Valley Fever: Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/a-to-z-guides/valley-fever
    Valley fever can be serious or fatal. In California, there have been over 1,000 hospitalizations each year with the infection. About 1 in 10 of these people have died in the hospital. […] The symptoms of this this infection will usually go away on their own after a few weeks or months. A small group of people will have ongoing symptoms in their lungs. If this continues, it’s called chronic pulmonary coccidioidomycosis and not valley fever anymore. With this, you may have no symptoms or have chest pains, shortness of breath, weight loss, cough up blood, of have a chronic cough.
  • #28 Valley fever // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/valley-fever
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] Signs and symptoms include: Low-grade fever, Weight loss, Cough, Chest pain, Blood-tinged sputum (matter discharged during coughing), Nodules in the lungs. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #29 Symptoms of Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/signs-symptoms/index.html
    Valley fever is a fungal lung infection and causes symptoms of pneumonia. […] Symptoms usually last for a few weeks to a few months. […] Rarely, Valley fever can cause severe lung infections or infections throughout the body. […] Symptoms include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Symptoms of Valley fever may appear between 1 and 3 weeks after a person breathes in the fungal spores. […] Symptoms usually last for a few weeks to a few months. However, some patients have symptoms that last longer than this, especially if the infection becomes severe. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body.
  • #30 Valley Fever – National Collaborating Centre for Infectious Diseases
    https://nccid.ca/debrief/valley-fever/
    The time between exposure to the fungus and when symptoms develop ranges from 1 to 3 weeks and symptoms of Valley fever can last weeks to months. 60% of people infected with Valley fever are asymptomatic, while most others will experience mild symptoms. If an infected person has a normal immune response, and apart from complications, Valley fever will generally resolve without treatment. Symptoms of Valley fever can include: […] Between 5-10% of people who contract Valley fever will develop a severe, chronic form called pulmonary coccidioidomycosis. This can occur months to years after first being exposed to the fungus. It is characterized by pneumonia, pleural effusion, and hilar lymphadenopathy; cavities can also develop in the infected lungs. Less than 1% of Valley fever infections spread to other parts of the body. When they do, infections can include the skin, bones, joints, and nervous system (brain and spinal cord). The latter can lead to meningitis, a serious complication, which occurs in 30-50% of disseminated infections. People who have a weakened immune system, are pregnant, or are diabetic are at highest risk of developing pulmonary coccidioidomycosis.
  • #31 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Lung nodules are the result of pneumonia caused by Valley fever. Nodules are small residual patches of infection that generally appear as single lesions, typically one to one and one-half inches in diameter. Patients who have no symptoms as well as patients who do have symptoms may develop nodules. Approximately 5-7% of patients with cocci pneumonia will form sharply circumscribed singular nodules. If it is documented that the nodule is caused by Valley fever, no other treatment is required. However, because the nodule may appear to be cancer, a biopsy or removal may be necessary. Nodules caused by cocci may remain a life-time.
  • #32 FAQs | Valley Fever Task Force
    http://valleyfevertaskforce-schweikert.house.gov/helpful-resources/faqs
    Lung nodules are the result of pneumonia caused by Valley Fever. Nodules are small residual patches of infection that generally appear as single lesions, typically one to one and one-half inches in diameter. Patients who have no symptoms as well as patients who do have symptoms may develop nodules. Approximately 5-7% of patients with cocci pneumonia will form sharply circumscribed singular nodules. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley Fever may last years, with a waxing and waning course. […] Patients with this manifestation present with chronic systemic symptoms such as low grade Fever, weight loss, cough, chest pain and coughing blood. These symptoms are often slowly progressive and resemble tuberculosis when coupled with x-ray findings. […] Scarring is frequently found and correlates to the severity of illness. Many persons have such a mild case they have no symptoms and no scarring.
  • #33 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Patients with this manifestation present with chronic systemic symptoms such as low grade fever, weight loss, cough, chest pain and coughing blood. These symptoms are often slowly progressive and resemble tuberculosis when coupled with x-ray findings. […] Scarring is frequently found and correlates to the severity of illness. Many persons have such a mild case they have no symptoms and no scarring. […] Cavities occur in about 5% of patients with pulmonary cocci. The typical cocci cavity is thin-walled and solitary. Coccidioidal cavities are commonly asymptomatic (do not cause symptoms) and about 50% will disappear within 2 years of their occurrence. A cavity may persist for years with minor changes. About one-third of the patients with cavities may experience hemoptysis (coughing blood). The hemoptysis is often recurrent but generally not life-threatening. If rupture of the cavity is a large possibility, surgical removal may be necessary.
  • #34 Valley Fever Causes, Symptoms, Diagnosis, Treatment
    https://www.medicinenet.com/valley_fever/article.htm
    Chronic coccidioidomycosis occurs in about 8% of patients and may spread from the lungs to other parts of the body. People develop lung cavities that may disappear in about two years or become calcified. […] Progressive pulmonary coccidioidomycosis includes the above symptoms but progresses to lung volume loss, fibrosis (scarring), and inflammation, considered serious complications of the disease. […] Disseminated coccidioidomycosis (about 1% of cases) can be characterized by the above symptoms, but they may occur over weeks to years and can be life threatening. The fungi live in any organ system but are most frequently seen in the skin, meninges, spinal cord, and bones. In a few individuals, the disease is rapidly fatal. Disseminated disease occurs most often in immunosuppressed individuals, males, and pregnant females.
  • #35 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #36 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #37 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #38 Symptoms of Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/signs-symptoms/index.html
    Valley fever is a fungal lung infection and causes symptoms of pneumonia. […] Symptoms usually last for a few weeks to a few months. […] Rarely, Valley fever can cause severe lung infections or infections throughout the body. […] Symptoms include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Symptoms of Valley fever may appear between 1 and 3 weeks after a person breathes in the fungal spores. […] Symptoms usually last for a few weeks to a few months. However, some patients have symptoms that last longer than this, especially if the infection becomes severe. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body.
  • #39 About Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/about/index.html
    Valley fever causes typical lung infection symptoms like cough and fever. […] Some people who are exposed to the fungus never have symptoms. Other people may have symptoms that include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body. This includes skin, bones, joints, or brain (meningitis).
  • #40 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #41 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    Valley fever is an infection that occurs when the spores of the fungus Coccidioides immitis or Coccidioides posadasii enter your body through the lungs. […] Most people with an infection by this fungus never have symptoms. Others may have cold- or flu-like symptoms or symptoms of pneumonia. If symptoms occur, they typically start 5 to 21 days after exposure to the fungus. […] Common symptoms include: Ankle, feet, and leg swelling, Chest pain (can vary from mild to severe), Cough, possibly producing blood-tinged phlegm (sputum), Fever and night sweats, Headache, Joint stiffness and pain or muscle aches, Loss of appetite, Painful, red lumps on lower legs (erythema nodosum). […] Rarely, the infection spreads from the lungs through the bloodstream to involve the skin, bones, joints, lymph nodes, and central nervous system or other organs. This spread is called disseminated coccidioidomycosis.
  • #42 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #43 Valley fever // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/valley-fever
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] Signs and symptoms include: Low-grade fever, Weight loss, Cough, Chest pain, Blood-tinged sputum (matter discharged during coughing), Nodules in the lungs. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #44 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #45 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #46 What’s New
    https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/ValleyFeverSymptoms.aspx
    Most common symptoms of Valley fever: fatigue, cough, difficulty breathing, and fever. […] Valley fever can affect people in different ways. Some people with Valley fever may only have mild symptoms that get better on their own in a few weeks. In others, symptoms like fatigue can take longer to go away and can last for several months. […] In rare cases, Valley fever can cause severe infections in the lungs or in other parts of the body (called disseminated disease). People with severe Valley fever may need to be hospitalized, and they will likely need follow-up medical care for several months or even years. If Valley fever infects the brain (called meningitis), a person will probably need lifelong treatment. In very rare cases, severe Valley fever can be fatal. […] Disseminated Valley fever usually causes infections in the skin, bones, joints, or brain, and severe symptoms can include: Skin lesions, Bone or joint pain, Severe headaches.
  • #47 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #48 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #49 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #50 Valley fever – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/symptoms-causes/syc-20378761
    If the initial coccidioidomycosis infection doesn’t completely resolve, it may progress to a chronic form of pneumonia. This complication is most common in people with weakened immune systems. […] The most serious form of the disease, disseminated coccidioidomycosis, is uncommon. It occurs when the infection spreads (disseminates) beyond the lungs to other parts of the body. Most often these parts include the skin, bones, liver, brain, heart, and the membranes that protect the brain and spinal cord (meninges). […] Signs and symptoms of disseminated disease depend on the body parts affected and may include: Nodules, ulcers and skin lesions that are more serious than the rash that sometimes occurs with initial infection, Painful lesions in the skull, spine or other bones, Painful, swollen joints, especially in the knees or ankles, Meningitis an infection of the membranes and fluid surrounding the brain and spinal cord.
  • #51 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #52 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #53 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #54 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #55 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    People with this more widespread form may become very sick. Symptoms may also include: Change in mental status, Enlarged or draining lymph nodes, Joint swelling, More severe lung symptoms, Neck stiffness, Sensitivity to light, Weight loss. […] Skin lesions of valley fever are often a sign of widespread (disseminated) disease. With more widespread infection, skin sores or lesions are most often seen on the face.
  • #56
    https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=za1349
    Most people don’t have any symptoms, or they have only very mild symptoms. If you do have symptoms, you may feel like you have a cold or influenza (flu). You may have a fever, chills, chest pain, a dry cough, and a rash. […] The time from contact with the fungus until symptoms start is usually 1 to 3 weeks. This is called the incubation period. […] In rare cases, valley fever can spread to the skin, bones, lymph nodes, and organs. It can lead to meningitis, a very serious infection of the coverings around the brain and spinal cord. […] The disease is more likely to spread to other areas of the body in people who have weak immune systems. This includes pregnant women, people who have HIV, people who take medicines that weaken the immune system, and people who have diabetes. […] Talk with your doctor if your symptoms are severe or last more than a few weeks, or if you have a weak immune system and have valley fever.
  • #57 Valley Fever Information & Treatment
    https://www.columbiadoctors.org/health-library/condition/valley-fever/
    The disease is more likely to spread to other areas of the body in people who have weak immune systems. This includes pregnant women, people who have HIV, people who take medicines that weaken the immune system, and people who have diabetes. […] Talk with your doctor if your symptoms are severe or last more than a few weeks, or if you have a weak immune system and have valley fever.
  • #58 Valley Fever – Skin Center
    https://www.skincenter.com/patient-education/healthwise?DOCHWID=za1349
    Valley fever is a disease caused by a fungus that gets into your body through your lungs. It can make you feel like you have a cold or the flu and may cause a rash. Most people get better without treatment. […] If you do have symptoms, you may feel like you have a cold or the flu. You may have a fever, chills, chest pain, a dry cough, and a rash. […] The time from contact with the fungus until symptoms start is usually 1 to 3 weeks. This is called the incubation period. […] In rare cases, valley fever can spread to the skin, bones, lymph nodes, and organs. It can lead to meningitis, a very serious infection of the coverings around the brain and spinal cord. […] The disease is more likely to spread to other areas of the body in people who have weak immune systems. This includes pregnant women, people who have HIV, people who take medicines that weaken the immune system, and people who have diabetes. […] Talk with your doctor if your symptoms are severe or last more than a few weeks, or if you have a weak immune system and have valley fever.
  • #59
    https://www.cbsnews.com/news/valley-fever-symptoms-fungus-disease/
    While some people recover on their own, dangerous complications can develop in as many as 10% of cases, the CDC says. […] Certain factors can also increase a person’s risk of getting a severe case, including being 60 years of age or older, having diabetes or a condition that weakens the immune system, or being pregnant, according to California’s Department of Public Health.
  • #60 Soil to Lungs: The Expanding Threat of Valley Fever
    https://www.contagionlive.com/view/soil-to-lungs-climate-change-and-the-expanding-threat-of-valley-fever
    The group that is most at risk of complications is immunosuppressed people. Because organ transplants and cases of HIV infection, says Galgiani for example. Older individuals have more of a problem managing this disease than younger individuals. diabetics have more complications than non-diabetics, women in their second and third trimester, especially during pregnancy.
  • #61 Coccidioidomycosis (Valley Fever) (U.S. National Park Service)
    http://home.nps.gov/articles/coccidioidomycosis.htm
    Valley fever, also called coccidioidomycosis, is an infection caused by the fungus Coccidioides, which is found in soil throughout the southwestern United States. Symptoms of Valley fever include fatigue, cough, fever, shortness of breath, headache, night sweats, muscle aches or joint pain, and a rash on the upper body or legs. If someone does become ill, symptoms usually appear between 1 and 3 weeks after a person breathes in the fungal spores. Approximately 5 to 10% of people who get Valley fever will develop serious or long-term lung problems. People who become ill with Valley fever usually recover on their own in weeks to months, but some people need antifungal medication to recover fully. […] In rare cases, the infection can spread from the lungs to other parts of the body. Certain groups of people (including those people who have weakened immune systems or diabetes, people who are pregnant, and people who are Black or Filipino) are at higher risk for becoming severely ill. […] If you develop symptoms of Valley fever and live or have traveled to an area where the fungus is present, contact your healthcare provider and let them know your concerns. They can prescribe anti-fungal medications if necessary.
  • #62 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    In most cases, people with Valley fever infections recover without any long-term effects. A small number of people develop ongoing lung infections that may take several years to resolve. Less than 1% of people diagnosed with Valley fever die from it. […] Symptoms of Valley fever usually go away on their own after a few weeks or months. […] A small number of people can have ongoing disease in their lungs. If it goes on for a long time, it’s usually called chronic pulmonary coccidioidomycosis instead of Valley fever. This may be symptomless or cause symptoms like: Chronic cough, Coughing up blood (hemoptysis), Weight loss, Chest pain, Shortness of breath (dyspnea).
  • #63 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    In most cases, people with Valley fever infections recover without any long-term effects. A small number of people develop ongoing lung infections that may take several years to resolve. Less than 1% of people diagnosed with Valley fever die from it. […] Symptoms of Valley fever usually go away on their own after a few weeks or months. […] A small number of people can have ongoing disease in their lungs. If it goes on for a long time, it’s usually called chronic pulmonary coccidioidomycosis instead of Valley fever. This may be symptomless or cause symptoms like: Chronic cough, Coughing up blood (hemoptysis), Weight loss, Chest pain, Shortness of breath (dyspnea).
  • #64 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    When seen together, fever, nodules under the skin and joint stiffness are sometimes called „desert rheumatism.” […] Complications of Valley fever are uncommon, with only about 1% of those who are symptomatic going on to develop severe disease. Serious complications include: Pneumonia, Fluid or pus in your lungs (pleural effusion or empyema), Acute respiratory distress syndrome (ARDS), Ruptured pockets of fluid or air in your lungs (hydropneumothorax), Disease spread outside of your lungs (disseminated coccidioidomycosis). […] One of the most serious complications of Valley fever is when the fungus spreads outside of your lungs. It can spread to your skin, bones, joints, liver, pancreas, kidneys and brain. When coccidioidomycosis spreads to your brain, you can develop coccidioidal meningitis, a life-threatening condition. Symptoms of coccidioidal meningitis include: Headaches, Blurred vision, Sensitivity to light, Neck stiffness, Hearing changes, Confusion.
  • #65 Valley Fever: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17754-valley-fever
    In most cases, people with Valley fever infections recover without any long-term effects. A small number of people develop ongoing lung infections that may take several years to resolve. Less than 1% of people diagnosed with Valley fever die from it. […] Symptoms of Valley fever usually go away on their own after a few weeks or months. […] A small number of people can have ongoing disease in their lungs. If it goes on for a long time, it’s usually called chronic pulmonary coccidioidomycosis instead of Valley fever. This may be symptomless or cause symptoms like: Chronic cough, Coughing up blood (hemoptysis), Weight loss, Chest pain, Shortness of breath (dyspnea).
  • #66 Valley Fever – National Collaborating Centre for Infectious Diseases
    https://nccid.ca/debrief/valley-fever/
    The time between exposure to the fungus and when symptoms develop ranges from 1 to 3 weeks and symptoms of Valley fever can last weeks to months. 60% of people infected with Valley fever are asymptomatic, while most others will experience mild symptoms. If an infected person has a normal immune response, and apart from complications, Valley fever will generally resolve without treatment. Symptoms of Valley fever can include: […] Between 5-10% of people who contract Valley fever will develop a severe, chronic form called pulmonary coccidioidomycosis. This can occur months to years after first being exposed to the fungus. It is characterized by pneumonia, pleural effusion, and hilar lymphadenopathy; cavities can also develop in the infected lungs. Less than 1% of Valley fever infections spread to other parts of the body. When they do, infections can include the skin, bones, joints, and nervous system (brain and spinal cord). The latter can lead to meningitis, a serious complication, which occurs in 30-50% of disseminated infections. People who have a weakened immune system, are pregnant, or are diabetic are at highest risk of developing pulmonary coccidioidomycosis.
  • #67 Coccidioidomycosis – Infections – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/infections/fungal-infections/coccidioidomycosis
    Coccidioidomycosis may also spread from the lungs to the skin and other tissues. If infection spreads to the skin, people may have one sore or many. Joints may become swollen and painful. Deep infections sometimes break through the skin, causing an opening that infected material drains through. […] With either form of coccidioidomycosis, some people have an allergic reaction to the fungus, which can cause joint pain, conjunctivitis, tender red or violet bumps (nodules) under the skin (called erythema nodosum), or patches of red, raised skin that often look like targets (erythema multiforme). […] Coccidioidomycosis that spreads from the lungs to the skin may cause only a single sore. […] Coccidioidomycosis is usually fatal unless it is treated, particularly if the immune system is weakened. About 70% of people with severe HIV infection or AIDS die within 1 month after being diagnosed. For mild to moderate progressive coccidioidomycosis, fluconazole or itraconazole is given by mouth. Alternatively, the doctor may treat the infection with voriconazole, given by mouth or by vein (intravenously), or posaconazole, given by mouth. For severe progressive coccidioidomycosis, amphotericin B is given intravenously.
  • #68 Valley Fever Facts – What is Valley Fever? – Nielsen Biosciences
    https://nielsenbio.com/spherusol-hcp/valley-fever-facts/
    Many people, about 60%, who are infected do not have any substantial clinical symptoms. […] About 40% of people infected will have symptoms of disease, typically lung disease. Symptoms may include (but not limited to) fatigue, cough, chest pain, fever, night sweats, rash, weight loss, headache, and joint aches. […] In about 1-2% of all infections, the disease spreads (disseminates). The most common site of spread is in the skin, but Coccidioides may spread to bone, joints, or most other soft tissues. […] Symptoms of spread to the nervous system includes headaches, neck pain, nausea, back pain or stiffness, and anyone with those symptoms should seek medical care immediately. […] Long-term consequences may include the formation of cavities or nodules in the chest or fungal abscesses. […] Early diagnosis and proper management of Valley Fever is important.
  • #69 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. […] When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley fever may last years, with a waxing and waning course. […] Symptoms usually develop within 7-28 days after exposure.
  • #70 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Patients with this manifestation present with chronic systemic symptoms such as low grade fever, weight loss, cough, chest pain and coughing blood. These symptoms are often slowly progressive and resemble tuberculosis when coupled with x-ray findings. […] Scarring is frequently found and correlates to the severity of illness. Many persons have such a mild case they have no symptoms and no scarring. […] Cavities occur in about 5% of patients with pulmonary cocci. The typical cocci cavity is thin-walled and solitary. Coccidioidal cavities are commonly asymptomatic (do not cause symptoms) and about 50% will disappear within 2 years of their occurrence. A cavity may persist for years with minor changes. About one-third of the patients with cavities may experience hemoptysis (coughing blood). The hemoptysis is often recurrent but generally not life-threatening. If rupture of the cavity is a large possibility, surgical removal may be necessary.
  • #71 Valley fever – Diagnosis & treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/diagnosis-treatment/drc-20378765
    To diagnose valley fever, your doctor may evaluate your medical history and review your signs and symptoms. Valley fever is difficult to diagnose based on the signs and symptoms, because symptoms are usually vague and similar to those that occur in other illnesses. […] If symptoms don’t improve, last a long time or become worse, or you’re at increased risk of complications, your doctor may prescribe an antifungal medication, such as fluconazole. Antifungal medications are also used for people with chronic or disseminated disease. […] For many people, a single bout of valley fever results in lifelong immunity. But the disease can be reactivated, or you can be reinfected if your immune system is significantly weakened.
  • #72 Understanding and Managing Valley Fever | Banner Health
    https://www.bannerhealth.com/services/infectious-disease/treatment/valley-fever
    Valley fever, or coccidioidomycosis (cocci), is a fungal infection you can get if you breathe in spores of the fungus Coccidioides. Its also called desert rheumatism and San Joaquin Valley fever. […] Some people dont have any symptoms or even know they were infected. Others have mild symptoms like the flu, while some have more serious complications that need medical care. […] If symptoms develop, they usually appear one to three weeks after youve inhaled spores and include: Fever, Cough, Chest pain, Fatigue, Shortness of breath, Headache, Muscle aches or joint pain, Night sweats, Chills, Skin rash. […] Valley fever is not contagious from person to person. Most of the time, if youve had Valley fever once, you wont get it again. If you have a compromised immune system, though, you may have your original infection recur or could be reinfected.
  • #73 Symptoms of Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/signs-symptoms/index.html
    Valley fever is a fungal lung infection and causes symptoms of pneumonia. […] Symptoms usually last for a few weeks to a few months. […] Rarely, Valley fever can cause severe lung infections or infections throughout the body. […] Symptoms include: Fatigue (tiredness), Cough, Fever and headache, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Symptoms of Valley fever may appear between 1 and 3 weeks after a person breathes in the fungal spores. […] Symptoms usually last for a few weeks to a few months. However, some patients have symptoms that last longer than this, especially if the infection becomes severe. […] Approximately 5 to 10% of people who get Valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body.
  • #74 Coccidioidomycosis (Valley Fever) | County of Monterey, CA
    https://www.countyofmonterey.gov/government/departments-a-h/health/diseases/coccidioidomycosis-valley-fever
    Coccidioidomycosis, also called “Valley Fever”, is an infection caused by the fungus Coccidioides. The term “Valley Fever” usually refers to Coccidioides infection in the lungs, but the infection can spread to other parts of the body in severe cases (this is called “disseminated coccidioidomycosis”). […] Most people (60%) who are exposed to the fungus Coccidioides never have symptoms. Other people may have flu-like symptoms that go usually away on their own after weeks to months. Symptoms of valley fever include: Fatigue (tiredness), Cough lasting for more than four weeks, Fever, Shortness of breath, Headache, Night sweats, Muscle aches or joint pain, Rash on upper body or legs. […] Symptoms of valley fever may appear between 1 and 3 weeks after a person breathes in the fungal spores and usually last for a few weeks to a few months.
  • #75 What’s New
    https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/ValleyFeverSymptoms.aspx
    The symptoms of Valley fever are similar to other respiratory diseases, including COVID-19 and flu. Laboratory tests are needed to know whether symptoms are caused by Valley fever (which is caused by a fungus) or COVID-19 or flu (caused by viruses). Talk to a healthcare provider about testing to learn if symptoms could be Valley fever or another illness. […] Most people (about 6 in 10) who are infected with Valley fever have no symptoms, and their bodies will fight off the infection naturally. People who do get sick with Valley fever can have respiratory symptoms or pneumonia because the Valley fever fungus usually infects the lungs. Common symptoms that may develop 1 to 3 weeks after breathing in the fungus include: fatigue, cough, difficulty breathing, fever, night sweats, muscle or joint pain, chest pain, weight loss, headache, and rash.
  • #76 FAQs | Valley Fever Center For Excellence
    https://vfce.arizona.edu/valley-fever-people/faqs
    Most people (60%) have no symptoms or only very mild flu-like symptoms and do not see a doctor. […] When symptoms are present, the most common are fatigue, cough, fever, profuse sweating at night, loss of appetite, chest pain, generalized muscle and joint aches particularly of the ankles and knees. There may also be a rash that resembles measles or hives but develops more often as tender red bumps on the shins or forearms. […] The length of illness depends on the severity of the infection. Most cases have no symptoms, others may take months to even more than a year to resolve. Persons frequently complain of fatigue and joint aches lasting months. The chronic forms of Valley fever may last years, with a waxing and waning course. […] Symptoms usually develop within 7-28 days after exposure.
  • #77 Valley Fever Testing You Can Trust – MiraVista Diagnostics
    https://miravistalabs.com/clinical-resources/valley-fever-testing/
    Valley Fever is the common name for a fungal infection known as coccidioidomycosis. […] Most cases have no symptoms (which is why diagnosis can be difficult) while others may take months and even sometimes over a year to manifest. Those diagnosed with Valley Fever frequently complain of fatigue and joint aches that can last for months. The chronic forms of Valley Fever may last years. […] Patients are commonly misdiagnosed as pneumonia, as there are several similar symptoms. Most patients report flu-like symptoms that usually go away after a few weeks. Other symptoms include: Fatigue, Fever, Headache, Cough, Shortness of breath, Night sweats, Muscle aches or joint pain, Rash on upper body or legs.