Gorączka doliny
Charakterystyka, pielęgnacja i opieka

Gorączka Doliny (kokcydioidomikoza) jest grzybiczą infekcją wywołaną przez wdychanie zarodników Coccidioides immitis lub Coccidioides posadasii, endemicznych dla południowo-zachodnich rejonów USA. Objawy pojawiają się zwykle po 1-3 tygodniach i obejmują gorączkę, kaszel, ból w klatce piersiowej, zmęczenie, duszność, bóle mięśniowo-stawowe oraz wysypkę. Około 60% zakażonych pozostaje bezobjawowych, natomiast 5-10% rozwija powikłania płucne, a około 1% doświadcza rozsianej infekcji obejmującej OUN, skórę lub kości. W Kalifornii liczba przypadków wzrosła do 7000-9000 rocznie w latach 2018-2022. Diagnostyka opiera się na testach serologicznych (miana testów fiksacji dopełniacza) oraz obrazowaniu radiologicznym, które powinny być monitorowane do ustabilizowania stanu pacjenta.

Wprowadzenie do Gorączki Doliny (Valley Fever)

Gorączka Doliny (Valley Fever), znana również jako kokcydioidomykoza (coccidioidomycosis) lub „cocci”, jest chorobą wywołaną przez wdychanie zarodników grzybów Coccidioides immitis lub Coccidioides posadasii, które żyją w glebie w niektórych regionach Stanów Zjednoczonych, szczególnie w południowo-zachodniej części kraju.12 Choroba ta atakuje przede wszystkim płuca i może powodować objawy oddechowe, w tym kaszel, gorączkę, ból w klatce piersiowej i zmęczenie.3 Liczba przypadków Gorączki Doliny w Kalifornii znacznie wzrosła w ostatnich latach – przypadki potroiły się w latach 2014-2018, a w okresie 2018-2022 rocznie zgłaszano między 7000 a 9000 przypadków.4

Objawy Gorączki Doliny

Objawy Gorączki Doliny zwykle pojawiają się od jednego do trzech tygodni po wdychaniu zarodników i mogą obejmować:5

  • Gorączkę
  • Kaszel
  • Ból w klatce piersiowej
  • Zmęczenie
  • Duszność
  • Ból głowy
  • Bóle mięśni lub stawów
  • Poty nocne
  • Dreszcze
  • Wysypkę skórną

56

Około 60% osób zakażonych grzybem Coccidioides nigdy nie ma objawów. Inni mogą mieć objawy grypopodobne, które zazwyczaj ustępują samoistnie po kilku tygodniach lub miesiącach.7 Około 5-10% chorych może rozwinąć poważne lub długotrwałe problemy w płucach. U jeszcze mniejszego odsetka osób (około 1%) infekcja rozprzestrzenia się z płuc do innych części ciała, takich jak ośrodkowy układ nerwowy (mózg i rdzeń kręgowy), skóra lub kości i stawy.78

Leczenie i opieka nad pacjentem z Gorączką Doliny

Leczenie Gorączki Doliny zwykle obejmuje leczenie wspomagające, a czasami leki przeciwgrzybicze.9 Większość osób z ostrą Gorączką Doliny nie wymaga leczenia, jednak lekarze uważnie monitorują pacjentów z tą chorobą.910

Leczenie farmakologiczne

Jeśli objawy nie ustępują, utrzymują się przez długi czas, pogarszają się lub pacjent jest narażony na zwiększone ryzyko powikłań, lekarz może przepisać leki przeciwgrzybicze.9 Leki przeciwgrzybicze są również stosowane u osób z przewlekłą lub rozsianą postacią choroby.11

Najczęściej stosowane leki przeciwgrzybicze w leczeniu Gorączki Doliny to:1213

  • Flukonazol (Diflucan) – najczęściej stosowany lek doustny w przypadkach umiarkowanych do ciężkich
  • Itrakonazol (Sporanox, Tolsura) – alternatywny lek doustny, szczególnie zalecany u pacjentów z bólem stawów lub mięśni
  • Amfoterycyna B (Abelcet, Ambisome) – lek dożylny stosowany w bardzo ciężkich zakażeniach
  • Nowsze leki przeciwgrzybicze: worykonazol (Vfend), posakonazol (Noxafil) i izawukonazonium (Cresemba) – mogą być stosowane w poważniejszych zakażeniach

1413

U kobiet w ciąży zazwyczaj stosuje się dożylną amfoterycynę B, chociaż flukonazol można rozważyć w drugim i trzecim trymestrze.12 Pacjenci z grupy wysokiego ryzyka, którzy powinni otrzymać leczenie przeciwgrzybiczne, to osoby z:15

  • HIV/AIDS
  • Po przeszczepach narządów
  • Przyjmujący leki immunosupresyjne (np. wysokie dawki kortykosteroidów)
  • Stosujący inhibitory czynnika martwicy nowotworu
  • Cukrzycą
  • Chorobami sercowo-płucnymi
  • Kobiety w ciąży, szczególnie w okresie okołoporodowym

15

Czas trwania leczenia

Czas trwania leczenia przeciwgrzybiczego zależy od przebiegu klinicznego choroby.15 Zwykle leczenie trwa co najmniej 6 miesięcy u wszystkich pacjentów, a często rok lub dłużej u innych.1612 Terapia przeciwgrzybicza jest często przerywana po trzech do dwunastu miesiącach, jeśli miana testów fiksacji dopełniacza się stabilizują, radiografia klatki piersiowej wykazuje stabilizację, a objawy ustępują.12

W przypadku ciężkich zakażeń płuc lub zakażeń, które rozprzestrzeniły się na inne części ciała, kurs leczenia jest zwykle dłuższy niż 6 miesięcy.16 Gorączka Doliny, która rozwija się w zapalenie opon mózgowych, jest śmiertelna, jeśli nie jest leczona, dlatego w takich przypadkach konieczne jest dożywotnie leczenie przeciwgrzybicze.1612

Monitorowanie pacjenta

Zaleca się monitorowanie mian testów fiksacji dopełniacza i radiografii klatki piersiowej, dopóki pacjenci nie ustabilizują się i objawy nie ustąpią.17 U pacjentów leczonych lekami przeciwgrzybiczymi miana testów fiksacji dopełniacza powinny być śledzone przez co najmniej dwa lata, ponieważ leczenie przeciwgrzybicze wiązało się z opóźnionym rozsiewem.1217

Kobiety w ciąży z historią kokcydioidomikozy powinny mieć sprawdzane miana testów fiksacji dopełniacza co sześć do dwunastu tygodni, aby monitorować ich ewentualny wzrost, co sugerowałoby nawrót choroby.12

Aby upewnić się, że pacjent wraca do zdrowia, ważne jest odbywanie wizyt kontrolnych u lekarza. Pacjent może mieć wykonane zdjęcie rentgenowskie klatki piersiowej lub inny test krwi po kilku miesiącach w celu potwierdzenia.1018

Działania niepożądane leków

Wszystkie leki przeciwgrzybicze mogą mieć poważne działania niepożądane. Jednak te działania niepożądane zwykle ustępują po zaprzestaniu stosowania leku. Możliwe działania niepożądane flukonazolu i itrakonazolu to nudności, wymioty, ból brzucha i biegunka.9

Opieka wspomagająca

Wraz z lekami, pracownik służby zdrowia może zalecić zabiegi, które pomogą złagodzić objawy:19

  • Leki przeciwbólowe dostępne bez recepty, takie jak acetaminofen (Tylenol) lub ibuprofen (Advil), mogą pomóc w bólach mięśni, bólach stawów i gorączce
  • Odpoczynek i odpowiednia ilość płynów
  • Powolne zwiększanie aktywności w miarę poprawy samopoczucia

1920

Większość pacjentów z Gorączką Doliny w pełni wraca do zdrowia.16 Mały odsetek osób rozwija długotrwałe zakażenia płuc, które mogą wymagać kilku lat leczenia.16 W bardzo ciężkich przypadkach Gorączki Doliny, rzadko układ nerwowy może być dotknięty i mogą wystąpić długotrwałe uszkodzenia.16

Specjalne grupy pacjentów

Pacjenci z zaburzeniami odporności

Osoby z osłabionym układem odpornościowym mogą wymagać leczenia przeciwgrzybiczego amfoterycyną B, flukonazolem lub itrakonazolem.2 Itrakonazol jest lekiem z wyboru u osób z bólem stawów lub mięśni.2 Pacjenci z problemami immunologicznymi (np. z HIV/AIDS i osoby przyjmujące leki hamujące układ odpornościowy) nie powinni udawać się do obszarów, gdzie występuje ten grzyb.2

Osoby z obniżoną odpornością, u których rozwijają się poważne infekcje, mają trudności z odpowiedzią na leczenie przeciwgrzybicze.21 Wyzwanie to jest szczególnie widoczne u pacjentów z ciężkimi objawami choroby, takimi jak zakażenia kości, mózgu lub skóry, gdzie układ odpornościowy organizmu nie skutecznie kontroluje infekcję.21

Pacjenci z postaciami rozsianymi

W przypadku przewlekłych lub rozsianych zakażeń wymagane jest długotrwałe leczenie przeciwgrzybicze, czasami dożywotnie.22 Jest to szczególnie ważne dla pacjentów z obniżoną odpornością lub z zapaleniem opon mózgowych, ponieważ zakażenie może być śmiertelne bez leczenia.22

Bez leczenia, Gorączka Doliny, która rozprzestrzeniła się poza płuca, jest zwykle śmiertelna. U pacjentów z niskim ryzykiem, postać ograniczona do płuc zwykle nie wymaga leczenia.23 Leczenie może obejmować:23

  • Leki przeciwgrzybicze, takie jak flukonazol lub amfoterycyna B
  • Zabieg chirurgiczny usunięcia zajętej kości, jeśli występuje zapalenie szpiku kostnego

23

Hospitalizacja

Potrzeba hospitalizacji u pacjentów z kokcydioidomykozą jest dyktowana przez objawy i ciężkość choroby i nie różni się od pacjentów z jakimkolwiek innym schorzeniem oddechowym.15 Osoby, które mają ciężkie zakażenia płuc lub zakażenia, które rozprzestrzeniły się na inne części ciała, mogą potrzebować hospitalizacji.16

Zapobieganie i edukacja

Najlepszym sposobem zmniejszenia ryzyka zachorowania na kokcydioidomykozę jest unikanie wdychania kurzu lub pyłu.24 Istnieje kilka zaleceń opartych na zdrowym rozsądku, które mogą pomóc:2

  • Zamykanie okien podczas burz pyłowych
  • Unikanie czynności związanych z obsługą gleby, takich jak ogrodnictwo
  • Przyjmowanie leków zapobiegawczych zgodnie z zaleceniami lekarza

2

Osoby pracujące na zewnątrz w obszarach, gdzie występuje Gorączka Doliny, powinny porozmawiać ze swoim pracodawcą lub właścicielem nieruchomości o tym, jak zapobiegać zakażeniu.25 Kroki te są szczególnie ważne dla osób, które są w grupie wysokiego ryzyka.25

Pracownicy, którzy uważają, że byli narażeni na kontakt z Coccidioides w pracy, powinni zgłosić się do działu zdrowia zawodowego lub zarządzania ryzykiem.26 Jeśli u pracownika rozwiną się objawy Gorączki Doliny, powinien on zobaczyć się z pracownikiem służby zdrowia w celu wykonania badań i ewentualnego leczenia przeciwgrzybiczego.26

Edukacja pacjenta

Edukacja pacjentów i zwiększanie świadomości są kluczowe dla poprawy wczesnej diagnozy.27 Pacjenci zdiagnozowani we wczesnym stadium choroby mają tendencję do lepszych wyników leczenia.27 Infekcja naprawdę nie zdążyła się jeszcze w pełni rozwinąć i pacjenci generalnie radzą sobie lepiej, im wcześniej zostają zdiagnozowani.27

Pacjenci powinni być poinformowani o konieczności kontaktu z lekarzem w przypadku wystąpienia objawów Gorączki Doliny, szczególnie jeśli trwają dłużej niż tydzień.28 Ważne jest, aby osoby z Gorączką Doliny były diagnozowane, ponieważ jeśli potrzebują leków, powinny je przyjmować i być monitorowane przez pracownika służby zdrowia.29

Wnioski i przyszłe kierunki

Większość osób z Gorączką Doliny w pełni wraca do zdrowia.16 Jednakże, choroba ta pozostaje poważnym problemem, szczególnie w regionach takich jak Kalifornia i Arizona.21 Naukowcy pracują nad lepszym zrozumieniem odpowiedzi gospodarza na Gorączkę Doliny oraz nad rozwojem nowych leków przeciwgrzybiczych i potencjalnych szczepionek.2130

W przypadku większości pacjentów z Gorączką Doliny, pojedynczy epizod choroby daje dożywotnią odporność. Jednak choroba może zostać reaktywowana lub może dojść do ponownego zakażenia, jeśli układ odpornościowy jest znacznie osłabiony.9

Badania kliniczne i programy edukacyjne są prowadzone w celu lepszego zrozumienia i leczenia Gorączki Doliny.31 Instytucje takie jak Valley Fever Institute prowadzą badania nad metodami leczenia i diagnostyką, aby zapewnić lepsze wyniki dla pacjentów.32

W świetle zmieniającego się klimatu i rosnącej liczby przypadków Gorączki Doliny, niezbędne jest dalsze badanie tej choroby i opracowanie skutecznych strategii zapobiegania i leczenia.33

Kolejne rozdziały

Zapraszamy do dalszego czytania naszego leksykonu.

Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 11.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Coccidioidomycosis (Valley Fever) in Primary Care | AAFP
    https://www.aafp.org/pubs/afp/issues/2020/0215/p221.html
    Primary pulmonary coccidioidomycosis (valley fever) is caused by inhaling airborne spores of the fungus Coccidioides immitis or Coccidioides posadasii. […] Antifungal agents are not recommended for treatment unless the patient is at risk of or shows signs of complicated or disseminated infection. […] When antifungals are used, fluconazole and itraconazole are most commonly recommended, except during pregnancy. […] Monitoring of complement fixation titers and chest radiography is recommended until patients stabilize and symptoms resolve. […] In patients who are treated with antifungals, complement fixation titers should be followed for at least two years. […] Antifungals are recommended for symptomatic patients who have clinically significant disease or an elevated risk of dissemination.
  • #2 Valley fever: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/001322.htm
    Valley fever is an infection that occurs when the spores of the fungus Coccidioides immitis or Coccidioides posadasii enter your body through the lungs. […] If you have a healthy immune system, the disease almost always goes away without treatment. Your provider may suggest bed rest and treatment for flu-like symptoms until your fever disappears. […] If you have a weak immune system, you may need antifungal treatment with amphotericin B, fluconazole, or itraconazole. Itraconazole is the medicine of choice in people with joint or muscle pain. […] Contact your provider for an appointment if you have symptoms of valley fever or if your condition does not improve with treatment. […] People with immune problems (such as with HIV/AIDS and those who are on medicines that suppress the immune system) shouldn’t go to areas where this fungus is found. If you already live in these areas, other measures that can be taken include: Closing windows during dust storms, Avoiding activities that involve handling soil, such as gardening. Take preventive medicines as prescribed by your provider.
  • #3 What’s New
    https://www.cdph.ca.gov/Programs/CID/DCDC/pages/Coccidioidomycosis.aspx
    Valley fever is on the rise in California. Learn what it is. Learn the symptoms. Learn how to help prevent it. […] In California, the number of reported Valley fever cases has greatly increased in recent years. Valley fever cases tripled from 2014-2018, and from 2018-2022, between 7,000 and 9,000 cases were reported each year. […] The Valley fever fungus can infect people who work or dig outdoors in certain areas in California, including wildland firefighters digging and moving soil to control fires. Fire safety crews working in California should learn about Valley fever and know the symptoms, which sometimes appear weeks after exposure to dust outdoors. […] Valley fever (also called coccidioidomycosis or cocci) is a disease caused by a fungus that grows in the soil and dirt in some areas of California and the southwestern United States. People and animals can get sick when they breathe in dust that contains the Valley fever fungus. This fungus usually infects the lungs and can cause respiratory symptoms including cough, fever, chest pain, and tiredness.
  • #4 What’s New
    https://www.cdph.ca.gov/Programs/CID/DCDC/pages/Coccidioidomycosis.aspx
    Valley fever is on the rise in California. Learn what it is. Learn the symptoms. Learn how to help prevent it. […] In California, the number of reported Valley fever cases has greatly increased in recent years. Valley fever cases tripled from 2014-2018, and from 2018-2022, between 7,000 and 9,000 cases were reported each year. […] The Valley fever fungus can infect people who work or dig outdoors in certain areas in California, including wildland firefighters digging and moving soil to control fires. Fire safety crews working in California should learn about Valley fever and know the symptoms, which sometimes appear weeks after exposure to dust outdoors. […] Valley fever (also called coccidioidomycosis or cocci) is a disease caused by a fungus that grows in the soil and dirt in some areas of California and the southwestern United States. People and animals can get sick when they breathe in dust that contains the Valley fever fungus. This fungus usually infects the lungs and can cause respiratory symptoms including cough, fever, chest pain, and tiredness.
  • #5 Understanding and Managing Valley Fever | Banner Health
    https://www.bannerhealth.com/services/infectious-disease/treatment/valley-fever
    Valley fever, or coccidioidomycosis (cocci), is a fungal infection you can get if you breathe in spores of the fungus Coccidioides. Its also called desert rheumatism and San Joaquin Valley fever. […] If symptoms develop, they usually appear one to three weeks after youve inhaled spores and include: Fever, Cough, Chest pain, Fatigue, Shortness of breath, Headache, Muscle aches or joint pain, Night sweats, Chills, Skin rash. […] If you live in or have recently traveled to an area where Valley fever is common and you have any of the symptoms above, you should seek medical care. […] To diagnose Valley fever, your health care provider will probably use a combination of medical history, a physical exam and lab tests. […] Most of the time, you dont need treatment for Valley fever. Your immune system will help you heal, although it may take a few weeks to a few months.
  • #6
    https://abcnews.go.com/Health/valley-fever-after-19-infected-california-music-festival/story?id=113452381
    Valley fever is contracted by breathing in spores of a certain fungus. […] Coccidioidomycosis, more commonly known as Valley fever, is a lung infection caused by breathing in spores from a fungus called Coccidioides, according to the Centers for Disease Control and Prevention (CDC). […] Those most at risk of severe disease include those with weakened immune systems, people with diabetes, older people and women who are pregnant, according to the CDC. […] Symptoms include cough, fever, headache, fatigue, shortness of breath, night sweats, muscle aches, joint pain and a rash. […] Patients usually experience symptoms from a few weeks to a few months. If an infection becomes severe, symptoms may last longer. […] Between 5% and 10% of Valley fever patients may develop serious or long-term lung problems and about 1% see the infection spread outside their lungs to other parts of the body, the CDC said.
  • #7 Coccidioidomycosis (Valley Fever) | County of Monterey, CA
    https://www.countyofmonterey.gov/government/departments-a-h/health/diseases/coccidioidomycosis-valley-fever
    Coccidioidomycosis, also called “Valley Fever”, is an infection caused by the fungus Coccidioides. The disease is also sometimes called “San Joaquin Valley fever” or “desert rheumatism.” The term “Valley Fever” usually refers to Coccidioides infection in the lungs, but the infection can spread to other parts of the body in severe cases (this is called “disseminated coccidioidomycosis”). […] Most people (60%) who are exposed to the fungus Coccidioides never have symptoms. Other people may have flu-like symptoms that go usually away on their own after weeks to months. Symptoms of valley fever include: […] Most people will have mild illness that resolves without special treatment. Approximately 5 to 10% of people who get valley fever will develop serious or long-term problems in their lungs. In an even smaller percent of people (about 1%), the infection spreads from the lungs to other parts of the body, such as the central nervous system (brain and spinal cord), skin, or bones and joints. This type of infection can be very serious and is sometimes fatal. Talk with your medical provider if you are concerned about coccidioidomycosis.
  • #8
    https://abcnews.go.com/Health/valley-fever-after-19-infected-california-music-festival/story?id=113452381
    Valley fever is contracted by breathing in spores of a certain fungus. […] Coccidioidomycosis, more commonly known as Valley fever, is a lung infection caused by breathing in spores from a fungus called Coccidioides, according to the Centers for Disease Control and Prevention (CDC). […] Those most at risk of severe disease include those with weakened immune systems, people with diabetes, older people and women who are pregnant, according to the CDC. […] Symptoms include cough, fever, headache, fatigue, shortness of breath, night sweats, muscle aches, joint pain and a rash. […] Patients usually experience symptoms from a few weeks to a few months. If an infection becomes severe, symptoms may last longer. […] Between 5% and 10% of Valley fever patients may develop serious or long-term lung problems and about 1% see the infection spread outside their lungs to other parts of the body, the CDC said.
  • #9 Valley fever – Diagnosis & treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/valley-fever/diagnosis-treatment/drc-20378765
    Valley fever usually involves supportive care and sometimes medications. […] Most people with acute valley fever don’t require treatment. Still, doctors carefully monitor people with valley fever. […] If symptoms don’t improve, last a long time or become worse, or you’re at increased risk of complications, your doctor may prescribe an antifungal medication, such as fluconazole. Antifungal medications are also used for people with chronic or disseminated disease. […] All antifungals can have serious side effects. But these side effects usually go away once the medication is stopped. Possible side effects of fluconazole and itraconazole are nausea, vomiting, stomach pain and diarrhea. […] For many people, a single bout of valley fever results in lifelong immunity. But the disease can be reactivated, or you can be reinfected if your immune system is significantly weakened.
  • #10 Valley Fever | The Children’s Hospital at Montefiore
    https://www.cham.org/health-library/article?id=za1349
    Most people with valley fever get better without treatment. […] For severe cases, doctors may prescribe antifungal medicines. […] People who are more likely to have the disease spread to other areas of the body often get antifungal medicines even if they have no symptoms. […] To make sure you are getting better, it’s important to have follow-up visits with your doctor. You may have a chest X-ray or another blood test after several months to make sure.
  • #11 Coccidioidomycosis (Valley Fever) in Primary Care | AAFP
    https://www.aafp.org/pubs/afp/issues/2020/0215/p221.html
    Primary pulmonary coccidioidomycosis (valley fever) is caused by inhaling airborne spores of the fungus Coccidioides immitis or Coccidioides posadasii. […] Antifungal agents are not recommended for treatment unless the patient is at risk of or shows signs of complicated or disseminated infection. […] When antifungals are used, fluconazole and itraconazole are most commonly recommended, except during pregnancy. […] Monitoring of complement fixation titers and chest radiography is recommended until patients stabilize and symptoms resolve. […] In patients who are treated with antifungals, complement fixation titers should be followed for at least two years. […] Antifungals are recommended for symptomatic patients who have clinically significant disease or an elevated risk of dissemination.
  • #12 Coccidioidomycosis (Valley Fever) in Primary Care | AAFP
    https://www.aafp.org/pubs/afp/issues/2020/0215/p221.html
    Nonpregnant, nonbreastfeeding adults are typically treated with oral fluconazole (Diflucan) or itraconazole (Sporanox). […] Pregnant women are normally treated with intravenous amphotericin B, although fluconazole can be considered during the second and third trimesters. […] If antifungals are given, serial complement fixation titers should be monitored for at least two years because antifungal treatment has been associated with delayed dissemination. […] Antifungal therapy is often discontinued after three to 12 months if complement fixation titers stabilize, chest radiography shows stabilization, and symptoms resolve. […] Pregnant women with a history of coccidioidomycosis should have complement fixation titers checked every six to 12 weeks to monitor for any elevation, which would suggest recrudescence. […] Coccidioidal meningitis is a serious complication that presents insidiously. […] If coccidioidal meningitis is confirmed, lifelong antifungal therapy is indicated.
  • #13 Valley fever | Beacon Health System
    https://www.beaconhealthsystem.org/library/diseases-and-conditions/valley-fever?content_id=CON-20378744
    Valley fever usually involves supportive care and sometimes medications. […] Most people with acute valley fever don’t require treatment. Still, doctors carefully monitor people with valley fever. […] If symptoms don’t improve, last a long time or become worse, or you’re at increased risk of complications, your doctor may prescribe an antifungal medication, such as fluconazole. Antifungal medications are also used for people with chronic or disseminated disease. […] The antifungal drugs fluconazole (Diflucan) or itraconazole (Sporanox, Tolsura) are generally used for all but the most serious forms of coccidioidomycosis disease. […] More serious infection may first be treated with an intravenous antifungal medication such as amphotericin B (Abelcet, Ambisome, others). […] Three newer medications voriconazole (Vfend), posaconazole (Noxafil) isavuconazonium sulfate (Cresemba) may also be used to treat more-serious infections.
  • #14 What is Valley Fever and who is at risk? | Heavens Urgent Care Apache Junction
    https://heavensurgentcare.com/what-is-valley-fever-and-who-is-at-risk/
    Valley fever is typically treated based on the severity of the infection. Here are the main treatment approaches: […] For mild cases: Most mild valley fever infections resolve on their own without treatment, only requiring rest and fluids. Doctors closely monitor patients with mild cases, but no medication is prescribed unless symptoms persist or worsen. […] For moderate to severe cases: Antifungal medications are prescribed, usually for 3-6 months. The most common antifungal drug used is fluconazole (Diflucan). Other azole antifungals like itraconazole (Sporanox) may also be used. For very severe infections that have spread beyond the lungs, intravenous amphotericin B may be used initially, followed by an oral azole. Newer antifungals like voriconazole (Vfend), posaconazole (Noxafil), or isavuconazonium (Cresemba) can treat serious infections.
  • #15 Coccidioidomycosis and Valley Fever Treatment & Management: Approach Considerations, Antifungal Medications, Investigational Agents
    https://emedicine.medscape.com/article/215978-treatment
    Treatment should definitely be offered to patients with the following risk factors: HIV/AIDS, Organ transplants, Immunosuppressive therapy (eg, high-dose corticosteroids), Tumor necrosis factor inhibitor therapy, Diabetes mellitus, Cardiopulmonary disease, Pregnancy, especially peripartum. […] Typical antifungal therapy of acute primary pulmonary coccidioidomycosis in these high-risk groups consists mainly of oral azoles at the recommended adult doses. […] The duration of therapy is dictated by the clinical course of the illness, but it should be at least 6 months in all patients and often a year or longer in others. […] The need for hospitalization in patients with coccidioidomycosis is dictated by symptoms and the severity of disease and does not differ from patients with any other respiratory condition.
  • #16 Treatment of Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/treatment/index.html
    Many people who get sick with Valley fever have mild symptoms. […] Healthcare providers may prescribe 3-6 months of oral antifungal medication like fluconazole. […] People who have severe lung infections or infections that have spread to other parts of the body need antifungal treatment. […] These people may need to be hospitalized and for these types of infections, the course of treatment is usually longer than 6 months. […] Valley fever that develops into meningitis is fatal if its not treated, so lifelong antifungal treatment is necessary for those cases. […] Most people who have Valley fever fully recover. […] A small percentage of people develop long-term lung infections that can take several years to get better. […] In very severe cases of Valley fever, rarely the nervous system can be affected and there may be long-term damage.
  • #17 Coccidioidomycosis (Valley Fever) in Primary Care | AAFP
    https://www.aafp.org/pubs/afp/issues/2020/0215/p221.html
    Primary pulmonary coccidioidomycosis (valley fever) is caused by inhaling airborne spores of the fungus Coccidioides immitis or Coccidioides posadasii. […] Antifungal agents are not recommended for treatment unless the patient is at risk of or shows signs of complicated or disseminated infection. […] When antifungals are used, fluconazole and itraconazole are most commonly recommended, except during pregnancy. […] Monitoring of complement fixation titers and chest radiography is recommended until patients stabilize and symptoms resolve. […] In patients who are treated with antifungals, complement fixation titers should be followed for at least two years. […] Antifungals are recommended for symptomatic patients who have clinically significant disease or an elevated risk of dissemination.
  • #18 Valley Fever Information & Treatment
    https://www.columbiadoctors.org/health-library/condition/valley-fever/
    Most people with valley fever get better without treatment. […] For severe cases, doctors may prescribe antifungal medicines. […] People who are more likely to have the disease spread to other areas of the body often get antifungal medicines even if they have no symptoms. […] To make sure you are getting better, it’s important to have follow-up visits with your doctor. […] You may have a chest X-ray or another blood test after several months to make sure.
  • #19 Understanding and Managing Valley Fever | Banner Health
    https://www.bannerhealth.com/services/infectious-disease/treatment/valley-fever
    If you need treatment, your health care provider may prescribe antifungal medications that fight the infection. […] Along with medication, your health care provider may recommend treatments to help reduce your symptoms: OTC pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil) may help with muscle aches, joint pain and fever. […] If you have Valley fever and your symptoms are getting worse or you have new health concerns, contact your health care provider. […] You can reduce your risk of Valley fever by minimizing your exposure to the fungus that causes it: Avoid breathing outdoors in dusty conditions. Stay indoors on windy days or during dust storms if you can. […] Most of the time, Valley fever doesnt cause symptoms or causes only mild symptoms and you can recover on your own. But sometimes it can cause a more severe infection. In those cases, you may need anti-fungal medications for treatment.
  • #20 Valley Fever | CommonSpirit Health
    https://www.commonspirit.org/conditions-treatments/valley-fever
    Most people with valley fever get better without treatment. […] For severe cases, doctors may prescribe antifungal medicines. […] People who are more likely to have the disease spread to other areas of the body often get antifungal medicines even if they have no symptoms. […] To make sure you are getting better, it’s important to have follow-up visits with your doctor. […] There are things you can do to feel better. For example, get plenty of rest. Slowly increase your activity as you start to feel better. Take over-the-counter medicines for pain or fever if needed. Go to any follow-up appointments. Contact your doctor if you don’t get better as expected.
  • #21 Immune Deficits in Some Valley Fever Patients Hinder Response to Antifungal Treatment
    https://www.contagionlive.com/view/immune-deficits-in-some-valley-fever-patients-hinder-response-to-antifungal-treatment
    Valley fever, caused by Coccidioides fungi, remains a serious concern, particularly in regions like California and Arizona. […] Thompson explains that despite the availability of antifungal drugs, some patients, even when treated with the correct medication, simply do not respond. […] This challenge is particularly pronounced in patients with severe disease manifestations, such as bone, brain, or skin infections, where the body’s immune system has failed to effectively control the infection. […] In response to these treatment challenges, Thompson and a group of researchers from UC San Diego, UCLA, Texas, and Northern Arizona University (NAU) have spent the past years focusing on the host response to valley fever. […] If we really understand how we control the infection, perhaps we can create a vaccine that will prevent it completely.
  • #22 What is Valley Fever and who is at risk? | Heavens Urgent Care Apache Junction
    https://heavensurgentcare.com/what-is-valley-fever-and-who-is-at-risk/
    For chronic or disseminated infections: Long-term antifungal treatment, sometimes lifelong, is required. This is especially important for immunocompromised patients or those with meningitis, as the infection can be fatal without treatment. […] Supportive care like rest, fluids, and management of symptoms is recommended for all cases of valley fever. Early diagnosis and appropriate antifungal therapy is crucial for preventing complications in moderate to severe infections. Most people with valley fever, recover on their own, but if you have any concerns seek immediate medical help. If you suspect you may have valley fever, it is important to see a healthcare provider for a proper diagnosis and treatment. Early detection and treatment can help prevent complications and promote a faster recovery.
  • #23 Valley Fever or San Joaquin Fever (Coccidiodomycosis) | Cedars-Sinai
    https://www.cedars-sinai.org/health-library/diseases-and-conditions/v/valley-fever-or-san-joaquin-fever-coccidiodomycosis.html
    Valley fever is an airborne fungal infection. It starts in the lungs, and if not treated, it spreads to the bones and destroys them. […] Without treatment, valley fever that has spread beyond the lungs is usually fatal. In low-risk patients, the form that is limited to the lungs usually does not require treatment. […] Treatment may include: Antifungal drugs, such as fluconazole or amphotericin B. […] Surgery to remove involved bone if osteomyelitis occurs.
  • #24 Coccidioidomycosis (Valley Fever) | County of Monterey, CA
    https://www.countyofmonterey.gov/government/departments-a-h/health/diseases/coccidioidomycosis-valley-fever
    The best way to reduce your risk of getting coccidioidomycosis is to avoid breathing in dirt or dust. Coccidioidomycosis can be difficult to prevent, but some common sense recommendations that may help are below. […] If you work in a job where dirt or soil is disturbed in a place where coccidioidomycosis is common, you and your employer may want to review the CDPH website for preventing work-related Valley Fever.
  • #25 Valley Fever: Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/a-to-z-guides/valley-fever
    Valley fever usually doesn’t need medical treatment. For people who are otherwise healthy, bed rest and drinking plenty of fluids are enough. Your doctor will keep a close watch on how you’re doing. […] If the symptoms hang on, get worse, or the infection spreads, your doctor might prescribe a drug that attacks illnesses caused by fungus. You may have to take the drug for three to six months. There are several options depending on how severe the symptoms are. […] Make the call if you have symptoms of valley fever and they last more than a week. Checking with a professional is especially important if you’re in a high-risk group. […] If you work or live in an area where valley fever is common, you should speak with your employer or landlord about how to prevent infection. […] These steps are particularly important for people who are at high risk.
  • #26 Reducing Risk for Valley Fever | Valley Fever | CDC
    https://www.cdc.gov/valley-fever/prevention/index.html
    Valley fever is a lung infection caused by breathing in spores from Coccidioides. […] Healthcare providers may prescribe antifungal medications to prevent infections in people at increased risk due to health conditions. […] Workers who think they were exposed to Coccidioides at work should report to their occupational health or risk management department. […] If a worker develops symptoms of Valley fever, should see a healthcare provider for testing and possible antifungal treatment.
  • #27 Immune Deficits in Some Valley Fever Patients Hinder Response to Antifungal Treatment
    https://www.contagionlive.com/view/immune-deficits-in-some-valley-fever-patients-hinder-response-to-antifungal-treatment
    Thompson notes that patients diagnosed early in the course of their illness tend to have better outcomes, The infection really hasn’t fully established itself, so to speak, and they generally do better the earlier they’re diagnosed. […] Educational initiatives and heightened awareness have been key to improving early diagnosis. […] While much of the focus has been on diagnosis and immune response, there is also news in the development of new antifungal treatments. […] These drugs are really needed, and we’re hopeful they’ll be available soon, said Thompson. […] Until then, the medical community continues to rely on existing therapies, though these new options could offer hope for patients whose infections do not respond to current treatments. […] Thompson also emphasizes the importance of a comprehensive patient history, especially when dealing with respiratory illnesses.
  • #28 Coccidioidomycosis (Valley Fever)
    https://www.sandiegocounty.gov/content/sdc/hhsa/programs/phs/community_epidemiology/dc/Coccidioidomycosis.html
    Coccidioidomycosis, also known as Valley Fever or Cocci, is a lung infection. […] Valley Fever is caused by Coccidioides, a fungus found in the soil. […] There is no vaccine to prevent Valley Fever. […] However, there are still ways to reduce exposure and infection, including: […] Certain jobs and work activities put workers at risk for Valley Fever. […] People can get Valley Fever by breathing in dust from outdoor air that contains spores of Coccidioides fungus that grows in the soil. […] Valley Fever is not contagious, meaning it cannot spread from one person, or animal, to another. […] If symptoms last for more than a week, contact your healthcare provider. […] Many people who get sick with Valley Fever have mild symptoms. […] For people with more serious infections, or risk factors for getting very sick, a healthcare provider may prescribe 3-6 months of oral antifungal medication. […] These people may need to be hospitalized and the course of treatment is usually longer than 6 months.
  • #29 What to know about Valley fever, a common lung infection in CA – CalMatters
    https://calmatters.org/health/2024/08/valley-fever/
    About 80 Californians die every year after contracting Valley fever, a fungal disease that typically affects the lungs. […] Many cases are mild and resolve on their own, but the infections, which are not contagious, can become serious enough to require hospitalization. About 80 Californians die every year from it. Moderate cases may last months and require antifungal medication. […] Health officials are encouraging people who attended the Lightning in a Bottle festival to contact their medical provider if they have been feeling sick and not improving. […] We want people with Valley fever to get diagnosed, because if they need medication, we want them to be on that medication and to be monitored by their healthcare provider. […] Some people may never develop symptoms, but those who do may experience a cough, fever, chest pain, headaches and fatigue. A rash and night sweats also may develop.
  • #30
    https://abcnews.go.com/Health/valley-fever-after-19-infected-california-music-festival/story?id=113452381
    Because Valley fever symptoms can resemble other infections, patients may consider getting tested if their symptoms do not improve, according to CDPH. […] However, for those who get more severely sick or are at risk for severe illness, they may be prescribed an oral anti-fungal medication, such as fluconazole, for three to six months. […] In rare cases, Valley fever can develop into meningitis, which is fatal if untreated, and could lead to lifelong anti-fungal treatment, according to the CDC. […] There are currently no vaccines that protect against Valley fever, although scientists are continuing to work on a vaccine, the CDC said. […] If you are not immunocompromised, do your best to not get exposed to large amounts of dust, in general, especially if you’re in those areas of California and Arizona.
  • #31 Tackling a deadly regional disease: Valley fever – Kaiser Permanente Department of Research & Evaluation
    https://www.kp-scalresearch.org/tackling-a-deadly-regional-disease-valley-fever/
    Recently, the clinical trials team and epidemiologists targeted a deadly regional disease: Valley fever. Also known as coccidioidomycosis, Valley fever is a respiratory disease caused by inhaling microscopic fungal spores that live in dry desert soil in the southwestern United States. […] To create a clinical trial program focused on Valley Fever, researchers had to go where the disease was affecting the most people, places where there had never been clinical trials beforethe Antelope Valley and Bakersfield in Kern County, California. […] She is working on a second study, which examines the sequence of events that Valley fever patients encounter as they make their way through the health care system. […] Now as patients come in with pneumonia-like symptoms, physicians ask them if they will be in the study. If they agree, physicians follow them for 2 years. […] The trial, he said, will help researchers and physicians to create a new protocol for best treating patients with Valley fever, helping to keep patients, and the community, healthier.
  • #32 The Institute – Valley Fever Institute
    https://valleyfeverinstitute.com/institute/
    Kern Medicals long history of caring for those suffering from Valley Fever began with Hans E. Einstein, MD. Dr. Einstein was the foremost authority on the disease and led our treatment of Valley Fever for decades. […] Our internationally recognized infectious disease experts have provided training on how to diagnose and treat Valley Fever to primary care physicians, specialists, and other healthcare providers throughout the state, with the goal of reducing the prevalence of misdiagnosis and delayed care. […] The Valley Fever Institute is ideally located in the heart of the Central Valley, where Coccidioides immitis, the fungus more commonly known as Valley Fever, lives in the soil around our neighborhoods, schools, farms, and businesses. […] In 2020, the Valley Fever Institute opened its new state-of-the-art research and treatment facility. Designed as a patient-centered specialty care clinic, the Valley Fever Institute incorporates patient care, treatment, support services, education, and research at a single location. […] Our research at the Valley Fever Institute is centered on treatments and diagnostics to provide improved outcomes for patients.
  • #33 Increased risk of Valley fever linked to fine mineral dust exposure | UC Berkeley Public Health
    https://publichealth.berkeley.edu/news-media/research-highlights/increased-risk-of-valley-fever-linked-to-fine-mineral-dust-exposure
    By understanding the link between dust exposure and Valley fever, public health officials can better target interventions, such as dust control measures and campaigns to increase public awareness of the risks associated with dust exposure, particularly among outdoor workers and those new to areas where Valley fever is prevalent, said Justin Remais, professor and chair of Environmental Health Sciences at UC Berkeley School of Public Health and principal investigator of the research project. […] We should take extra precautions to educate the public, employers, and health care providers about the unique risks of exposure to mineral dust during the summer and fall, he added. […] We need to be prepared for the possibility of continued increases in Valley fever incidence in the future, and we need information on where and when those increases are most likely, said Remais.