Atopowe zapalenie skóry (azs)
Diagnostyka i diagnoza
Atopowe zapalenie skóry (AZS) to przewlekła, nawracająca choroba zapalna skóry diagnozowana głównie na podstawie oceny klinicznej i badania fizykalnego, gdyż brak jest specyficznego testu laboratoryjnego. Kluczowymi kryteriami diagnostycznymi według Amerykańskiej Akademii Dermatologii są: obecność świądu, typowe zmiany skórne o charakterystycznym rozmieszczeniu zależnym od wieku (np. zajęcie twarzy i powierzchni wyprostnych u dzieci, zmiany w zgięciach u dorosłych), przewlekły lub nawracający przebieg oraz historia atopii osobistej lub rodzinnej. W diagnostyce pomocne są kryteria Hanifina i Rajki oraz uproszczone kryteria UK Working Party. Badania laboratoryjne, takie jak podwyższony poziom IgE (obecny u około 80% pacjentów) czy eozynofilia, nie są specyficzne, a biopsja skóry stosowana jest jedynie w celu wykluczenia innych dermatoz. Testy alergiczne nie są rutynowo zalecane ze względu na ryzyko fałszywie dodatnich wyników, jednak mogą być użyteczne w wybranych przypadkach, zwłaszcza u dzieci z ciężkim AZS.
Diagnostyka atopowego zapalenia skóry (AZS)
Atopowe zapalenie skóry (AZS) to przewlekła, nawracająca zapalna choroba skóry dotykająca około jednej na dziesięć osób w ciągu życia. Diagnoza AZS opiera się głównie na ocenie klinicznej i badaniu fizykalnym, gdyż nie istnieje żaden pojedynczy, specyficzny test laboratoryjny potwierdzający to schorzenie12. Około 80% pacjentów z atopowym zapaleniem skóry jest diagnozowanych i leczonych w warunkach podstawowej opieki zdrowotnej1.
Kryteria diagnostyczne
Amerykańska Akademia Dermatologii (AAD) opracowała uproszczone kryteria diagnostyczne oparte na objawach i wynikach badania fizykalnego12. Kryteria te rozróżniają:
- Cechy podstawowe, które muszą być obecne do rozpoznania, takie jak świąd (pruritus)13
- Cechy istotne, które potwierdzają rozpoznanie, takie jak wczesny wiek zachorowania1
- Cechy towarzyszące, które sugerują rozpoznanie, ale nie są specyficzne, takie jak pogrubienie skóry (lichenifikacja)1
Najczęściej stosowane kryteria diagnostyczne to kryteria Hanifina i Rajki, które wymagają spełnienia trzech z czterech głównych kryteriów oraz trzech z 23 mniejszych kryteriów45. Ze względu na ich złożoność, opracowano uproszczone wersje, takie jak kryteria UK Working Party, które wymagają obecności jednego obowiązkowego warunku (świąd) oraz trzech z pięciu dodatkowych kryteriów4.
Cechy diagnostyczne AZS
Zgodnie z kryteriami AAD, do podstawowych cech niezbędnych dla diagnozy AZS należą3:
- Świąd – uniwersalny objaw AZS, który może być na tyle silny, że powoduje zaburzenia snu, drażliwość i ogólny stres5
- Wyprysk (ostry, podostry, przewlekły) o typowej morfologii i charakterystycznym rozmieszczeniu zależnym od wieku:
- Zajęcie twarzy/szyi/powierzchni wyprostnych u dzieci
- Zmiany w zgięciach u osób w każdym wieku
- Oszczędzenie okolic pachwinowych i pachowych
- Przewlekły lub nawracający przebieg3
Do istotnych cech wspierających diagnozę zalicza się6:
- Wczesny wiek wystąpienia pierwszych objawów
- Atopia – osobista i/lub rodzinna historia chorób atopowych
- Reaktywność IgE
- Suchość skóry (xerosis)6
Proces diagnostyczny
Proces diagnostyczny atopowego zapalenia skóry obejmuje78:
- Dokładny wywiad medyczny – najważniejsze i najbardziej wiarygodne narzędzie diagnostyczne9:
- Historia osobista i rodzinna chorób atopowych (astma, alergiczny nieżyt nosa)
- Wiek wystąpienia pierwszych objawów
- Charakter i przebieg zmian skórnych
- Badanie fizykalne – ocena skóry pod kątem charakterystycznych zmian810:
- Wzorzec, lokalizacja i wygląd wysypki
- Zmiany typowe dla AZS: suchość, łuszczenie, zaczerwienienie, sączenie, strupy, lichenifikacja
W większości przypadków diagnoza może być postawiona na podstawie wywiadu i badania fizykalnego, bez konieczności wykonywania dodatkowych badań1011.
Badania diagnostyczne w atopowym zapaleniu skóry
Chociaż diagnoza AZS jest głównie kliniczna, w niektórych przypadkach lekarz może zlecić dodatkowe badania, aby wykluczyć inne schorzenia lub potwierdzić trudne przypadki129.
Badania laboratoryjne
Badania laboratoryjne rzadko są konieczne w diagnostyce AZS, ale mogą być pomocne w niektórych przypadkach13:
- Poziom IgE w surowicy – podwyższony u około 80% pacjentów z AZS, ale nie jest specyficzny dla tej choroby514
- Morfologia krwi – może wykazać eozynofilię obwodową, co może być przydatne w potwierdzeniu diagnozy13
- Badania molekularne – w niektórych przypadkach można wykonać badania na obecność mutacji w genie filagryny, jednej z przyczyn AZS15
Warto podkreślić, że nie ma żadnego biomarkera, który dokładnie odzwierciedlałby ciężkość AZS lub jego objawy, czy odróżniał AZS od innych chorób16.
Biopsja skóry
Biopsja skóry nie jest rutynowo wykonywana przy diagnostyce AZS, ale może być pomocna w wykluczeniu innych chorób skóry810:
- Procedura polega na pobraniu małego fragmentu skóry po miejscowym znieczuleniu8
- Próbka jest badana pod mikroskopem przez dermatopatologu, aby określić czy przyczyną zmian jest AZS czy inna choroba skóry8
- Wyniki biopsji są zwykle dostępne w ciągu 3-7 dni8
- Badanie histologiczne może wykazać charakterystyczny obraz ostrego, podostrego lub przewlekłego zapalenia gąbczastego, ale wyniki nie są specyficzne13
Biopsja skóry może również pomóc dermatologowi w wyborze najlepszego leczenia10.
Testy alergiczne
Testy alergiczne nie są rutynowo zalecane w diagnostyce AZS ze względu na wysokie ryzyko wyników fałszywie dodatnich, które mogą prowadzić do niepotrzebnego unikania pokarmów17. Mogą być jednak rozważone w określonych sytuacjach14:
- Testy skórne (prick tests) – wykonywane na alergeny pokarmowe lub wziewne w celu wykrycia uczulenia1518
- Testy płatkowe – pomocne w diagnozowaniu alergicznego kontaktowego zapalenia skóry1519
- Doustne próby prowokacyjne – mogą być stosowane do potwierdzenia alergii pokarmowych20
U dzieci poniżej 5 roku życia z umiarkowanym do ciężkiego AZS, które nie reagują na leczenie, zaleca się ocenę alergii na mleko, jajka, orzeszki ziemne, pszenicę i soję21.
Skale oceny ciężkości AZS
Do oceny nasilenia atopowego zapalenia skóry stosuje się różne skale1722:
- SCORAD (Scoring Atopic Dermatitis) – najczęściej stosowane narzędzie kliniczne do klasyfikacji ciężkości AZS na podstawie zajętego obszaru ciała i intensywności cech zmian1722
- EASI (Eczema Area and Severity Index) – opracowany jako modyfikacja dobrze ugruntowanego wskaźnika PASI22
- POEM (Patient-Oriented Eczema Measure) – zaprojektowany jako narzędzie raportowane przez pacjenta do pomiaru częstotliwości aktywności AZS22
Międzynarodowa grupa konsensusu HOME (Harmonizing Outcome Measures in Eczema) pracuje nad standaryzacją stosowania miar wyników AZS w badaniach klinicznych na całym świecie22.
Różnicowanie AZS z innymi chorobami skóry
Diagnoza AZS wymaga wykluczenia innych chorób skóry, które mogą prezentować podobne objawy2324:
- Łojotokowe zapalenie skóry – zazwyczaj zajmuje skórę owłosioną głowy i okolice bogate w gruczoły łojowe24
- Kontaktowe zapalenie skóry (alergiczne lub z podrażnienia) – reakcja skórna ograniczona do miejsca kontaktu z alergenem lub czynnikiem drażniącym24
- Łuszczyca – charakteryzuje się dobrze odgraniczonymi, grubymi, rumieniowymi, łuszczącymi się zmianami25
- Wyprysk pieniążkowaty (nieatopowy) – okrągłe lub owalne zmiany zapalne24
- Świerzb – zakaźna choroba skóry powodująca intensywny świąd24
- Ichtioza – grupa genetycznych chorób skóry charakteryzujących się suchością i łuszczeniem24
- Chłoniak skórny T-komórkowy – złośliwy rozrost limfocytów T w skórze24
Wskazówki pomocne w różnicowaniu AZS obejmują występowanie zmian w zgięciach oraz osobistą lub rodzinną historię alergicznego zapalenia spojówek i nosa oraz astmy25.
Kiedy szukać pomocy medycznej
Należy skonsultować się z lekarzem, gdy26:
- Występują objawy atopowego zapalenia skóry
- Stosowane leczenie nie przynosi poprawy
Pilna konsultacja lekarska jest wskazana, gdy26:
- AZS jest pęcherzowe, pokryte strupami, wycieka z niego płyn lub ma wypełnione ropą krosty
- Jest bolesne, opuchnięte lub ciepłe
- Nagle się pogarsza lub powiększa
- Występuje wysoka gorączka lub ogólne złe samopoczucie
Rola specjalistów w diagnostyce AZS
W diagnostyce i leczeniu atopowego zapalenia skóry mogą uczestniczyć różni specjaliści27:
- Dermatolodzy – specjaliści od chorób skóry, mogą przeprowadzić biopsję skóry w nietypowych przypadkach lub przy braku odpowiedzi na standardowe leczenie27
- Alergolodzy – mogą pomóc zidentyfikować czynniki wywołujące AZS (np. alergeny pokarmowe i środowiskowe) poprzez historię kliniczną i testy alergiczne27
W trudnych przypadkach AZS korzystne może być konsultowanie się z oboma specjalistami27.
Podejście diagnostyczne do AZS
Atopowe zapalenie skóry jest diagnozowane głównie klinicznie, na podstawie charakterystycznych objawów i badania fizykalnego28. Kluczowe w diagnozie są29:
- Obecność świądu i suchości skóry
- Charakterystyczne zmiany skórne i ich lokalizacja
- Przewlekły, nawracający przebieg
- Historia osobista lub rodzinna chorób atopowych
Badania laboratoryjne i testy alergiczne nie są rutynowo zalecane, ale mogą być przydatne w wykluczeniu innych chorób lub identyfikacji czynników wywołujących28. Właściwa diagnoza jest kluczowa dla wdrożenia odpowiedniego leczenia i poprawy jakości życia pacjentów z AZS30.
Wczesna diagnoza i rozpoczęcie leczenia AZS poprawia wyniki terapii i może zmniejszyć ryzyko rozwoju innych chorób atopowych, takich jak alergia pokarmowa, astma i katar sienny31.
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Materiały źródłowe
- #1 Atopic Dermatitis: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2020/0515/p590.html
Atopic dermatitis (atopic eczema) is a chronic relapsing and remitting inflammatory skin disease affecting one in 10 people in their lifetime. […] The American Academy of Dermatology has created simple diagnostic criteria based on symptoms and physical examination findings. […] Atopic dermatitis is a clinical diagnosis with no definitive laboratory test. Approximately 80% of patients with atopic dermatitis are diagnosed and treated in the primary care setting. […] The American Academy of Dermatology (AAD) has streamlined the diagnosis using previously validated diagnostic criteria. […] The AAD criteria differentiate essential features that must be present for diagnosis, such as pruritus; important features that support the diagnosis, such as early age at onset; and associated features that suggest the diagnosis but are nonspecific, such as lichenification.
- #2 Atopic Dermatitis: Diagnosis and Treatment – PubMedhttps://pubmed.ncbi.nlm.nih.gov/32412211/
Atopic dermatitis (atopic eczema) is a chronic relapsing and remitting inflammatory skin disease affecting one in 10 people in their lifetime. […] The American Academy of Dermatology has created simple diagnostic criteria based on symptoms and physical examination findings. […] The use of topical corticosteroids is the first-line treatment for atopic dermatitis flare-ups. […] Pimecrolimus and tacrolimus are topical calcineurin inhibitors that can be used in conjunction with topical corticosteroids as first-line treatment. […] Ultraviolet phototherapy is a safe and effective treatment for moderate to severe atopic dermatitis when first-line treatments are not adequate. […] Antistaphylococcal antibiotics are effective in treating secondary skin infections. […] Oral antihistamines are not recommended because they do not reduce pruritus.
- #3 Atopic Dermatitis: Practice Essentials, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/1049085-overview
Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that typically affects the face (cheeks), neck, arms, and legs but usually spares the groin and axillary regions. AD usually starts in early infancy, but also affects a substantial number of adults. […] Guidelines on diagnosis and assessment, topical therapy, phototherapy and systemic agents, and disease flares and adjunctive therapy were published by the American Academy of Dermatology (AAD) in 2014. […] The following features should be considered in the diagnosis of AD in accordance with the American Academy of Dermatology (AAD) 2014 Guidelines: Essential features (must be present) are as follows: Pruritus, Eczema (acute, subacute, chronic) – (1) Typical morphology and age-specific patterns (facial/neck/extensor involvement in children, flexural involvement in any age group, sparing of the groin and axillary regions); (2) chronic or relapsing history.
- #4 Atopic Dermatitis Diagnosis & Evaluation | Clinical Guidancehttps://www.healio.com/clinical-guidance/atopic-dermatitis/diagnosis-and-evaluation-diagnosis
The 1980 Hanifin and Rajka criteria are the original and most commonly employed diagnostic criteria for AD. A diagnosis of AD under the Hanifin and Rajka criteria requires that patients meet three of four major criteria and three of 23 minor criteria. Although comprehensive and used commonly in clinical trials, these criteria may not be practical in clinical practice for several reasons: 1) the large number of criteria are cumbersome, 2) some criteria are nonspecific, such as pityriasis alba; and 3) other criteria are uncommon in AD despite being fairly specific, such as upper lip cheilitis. As such, several groups have proposed modifications to address these limitations. […] The UK Working Party simplified the Hanifin and Rajka criteria, requiring patients to meet a single mandatory condition (i.e., itchy skin condition) plus three of five minor criteria. No laboratory testing is required, making these criteria better suited for epidemiologic and population-based studies, in addition to clinical practice. Both the Hanifin and Rajka criteria and UK criteria have been validated in studies and in a range of populations.
- #5 Atopic Dermatitis: A Review of Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/1999/0915/p1191.html
Atopic dermatitis is a common, potentially debilitating condition that can compromise quality of life. […] The diagnosis of atopic dermatitis is based on the findings of the history and physical examination. Exposure to possible exacerbating factors, such as aeroallergens, irritating chemicals, foods and emotional stress, should be investigated. […] Unfortunately, no specific laboratory findings or histologic features define atopic dermatitis. Although elevated IgE levels are found in up to 80 percent of affected patients, IgE levels are also elevated in patients with other atopic diseases. […] The diagnostic features of atopic dermatitis are listed in Table 1. The diagnosis requires the presence of at least three major features and at least three minor features. […] Pruritus is a universal finding in atopic dermatitis. The pruritus can be severe, sometimes causing sleep disruption, irritability and generalized stress for affected patients and family members.
- #6 Atopic Dermatitis: Practice Essentials, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/1049085-overview
Important features (supporting the diagnosis) are as follows: Early age of onset, Atopy – (1) Personal and/or family history; (2) IgE reactivity, Xerosis. […] Additional diagnostic considerations are as follows: No reliable biomarker exists for the diagnosis of AD, Laboratory testing is seldom necessary, but a complete blood count (CBC) can be useful to exclude immune deficiency; an IgE level can be helpful to confirm an atopic pattern; a swab of skin can be helpful to identify S aureus superinfection. […] Biopsy shows an acute, subacute, or chronic spongiotic dermatitis pattern that is nonspecific but can be helpful to rule out other conditions (eg, cutaneous T-cell lymphoma).
- #7 Atopic Dermatitis: Diagnosis, Treatment, and Steps to Takehttps://www.niams.nih.gov/health-topics/atopic-dermatitis/diagnosis-treatment-and-steps-to-take
Diagnosing atopic dermatitis may include the following: […] Examining your skin and the rash. […] Ordering laboratory tests, such as: […] Your doctor may need to see you or your child several times to make an accurate diagnosis and to determine if symptoms are from other diseases and conditions or from atopic dermatitis.
- #8 Diagnosing Eczema & Dermatitis | NYU Langone Healthhttps://nyulangone.org/conditions/eczema-dermatitis/diagnosis
NYU Langone dermatologists, with their extensive experience and expertise, may differentiate between atopic, contact, and nummular dermatitis simply by examining the distribution of the rash on your skin and asking questions about your family and medical history. […] A dermatologist carefully examines your skin during a physical exam. The pattern, location, and appearance of a rash provide our doctors with important information about its causes. […] If dermatologists suspect that allergic dermatitis is causing your rash, a patch test is the most effective diagnostic tool. […] A skin biopsy is a minor procedure performed in a doctors office. The doctor typically injects a local anesthetic to numb the skin and uses a scalpel, a sharp blade, or punch instrument to remove a small section of the rash. The biopsied area is covered by a bandage and heals within a week. […] In a lab, a pathologist who specializes in skin cells, called a dermatopathologist, examines the sample under a microscope to determine whether eczema or dermatitis is present or if a different skin condition accounts for the rash. Biopsy results take three to seven days.
- #9 Eczema Diagnosis | National Jewish Healthhttps://www.nationaljewish.org/conditions/eczema/do-i-have-eczema
People who suspect that they (or their children) have atopic dermatitis should carefully examine skin areas, keeping three questions in mind: […] If the answer to any one of these questions is yes, the next step is to consult a medical specialist–allergist/immunologists or dermatologists know a lot about eczema. They can get an in-depth history and perform additional diagnostic tests, if necessary, including: […] A detailed medical history is the most important and reliable tool for diagnosing eczema. […] While the medical history is of paramount importance, additional tests can help support the diagnosis of atopic dermatitis or identify other conditions that may be causing symptoms instead. Some of these tests are: […] Blood tests: These require a small blood sample, typically drawn through a needle in the arm.
- #10 Eczema types: Atopic dermatitis diagnosis and treatmenthttps://www.aad.org/public/diseases/eczema/types/atopic-dermatitis/treatment
How do dermatologists diagnose atopic dermatitis? To diagnose atopic dermatitis, also called eczema, a board-certified dermatologist carefully examines your (or your child’s) skin and asks questions. […] A skin exam along with information about your health and symptoms may be all your dermatologist needs to give you a diagnosis. Sometimes, a skin biopsy is required to make sure you have atopic dermatitis. […] A skin biopsy can also help your dermatologist select the best treatment.
- #11 Atopic Dermatitis Diagnosis: A Complete Guidehttps://www.everydayhealth.com/eczema/atopic-dermatitis-diagnosis-complete-guide/
Learn about skin exams, patch testing, and other methods for diagnosing atopic dermatitis, the most common type of eczema. Theres no single test that can diagnose atopic dermatitis (the most common type of eczema). Rather, diagnosing this skin condition requires a careful, multifaceted investigation of signs and symptoms by a health professional, such as a dermatologist. […] Most cases of atopic dermatitis can be diagnosed with just a medical history and skin exam, with no special testing required. […] Theres no single test that can diagnose atopic dermatitis, but the majority of cases can be diagnosed by a dermatologist based on your personal medical history, family history, and a skin exam. Occasionally, a dermatologist may need to run additional tests, such as patch testing or a biopsy, to confirm a diagnosis or rule out other health conditions.
- #12 Eczema: What It Is, Symptoms, Causes, Types & Treatmenthttps://my.clevelandclinic.org/health/diseases/9998-eczema
A healthcare provider will diagnose eczema after a physical exam, where they can take a close look at your skin. […] Symptoms of eczema can look similar to other conditions. Your provider might offer tests to rule out other conditions and confirm your diagnosis. Tests could include: […] An allergy test. […] Blood tests to check for causes of the rash that might be unrelated to dermatitis. […] A skin biopsy to distinguish one type of dermatitis from another. […] A primary care provider may recommend you visit a dermatologist to diagnose and treat your eczema. A dermatologist specializes in skin conditions.
- #13 Atopic Dermatitis Workup: Laboratory Studies, Histologic Findingshttps://emedicine.medscape.com/article/1049085-workup
No biomarker for the diagnosis of atopic dermatitis (AD) is known. Laboratory testing is seldom necessary. […] A swab of infected skin may help with the isolation of a specific organism (eg, Staphylococcus or Streptococcus) and antibiotic sensitivity. Allergy and radioallergosorbent testing is of little value. […] A swab for viral polymerase chain reaction (PCR) may help identify superinfection with herpes simplex virus and identify a diagnosis of eczema herpeticum. […] A complete blood count (CBC) for thrombocytopenia helps exclude Wiskott-Aldrich syndrome, and testing to rule out other immunodeficiencies may be helpful. This also helps identify peripheral eosinophilia, which may be useful for supporting the diagnosis. […] A serum immunoglobulin E (IgE) level can be useful for supporting the diagnosis. […] Scraping to exclude tinea corporis is occasionally helpful. […] Biopsy shows characteristic acute, subacute, or chronic spongiotic dermatitis, but findings are not specific.
- #14 Eczema Laboratory Testing | Rady Children’s Hospitalhttps://www.rchsd.org/programs-services/dermatology/eczema-and-inflammatory-skin-disease-center/laboratory-testing/
The diagnosis of atopic dermatitis is primarily clinical; thus routine laboratory testing is not recommended. […] Patients with atopic dermatitis may have elevated serum immunoglobulin E (IgE) levels, but this laboratory finding may also be seen with a variety of other disorders (i.e: asthma, allergies and the hyperimmunoglobulin E syndrome). Thus, elevated serum IgE is not specific to atopic dermatitis. […] Allergy testing is not routinely recommended for patients with atopic dermatitis. Allergy testing may be considered in a small subset of patients with moderate to severe atopic dermatitis, and/or a clinical history of allergic reaction following allergen exposure.
- #15 Eczema Diagnosis | National Jewish Healthhttps://www.nationaljewish.org/conditions/eczema/do-i-have-eczema
Skin biopsy: In this procedure a doctor first numbs the skin and then removes one or more small pieces of skin, which is used to rule out other skin diseases from atopic dermatitis, such as a low-grade skin cancer or psoriasis. […] Allergy skin testing: If there is concern for an associated food allergy or environmental allergy, prick skin tests can be done to common foods or inhalant/animal allergens to show sensitization or lack of sensitization to specific allergens. […] Patch testing: In this test, small patches covered with allergenic chemicals are placed on the skin for 48 hours, then removed and the skin reaction is evaluated at 72-96 hours. […] Buccal swabs: The inside of the cheek can be swabbed with a cotton applicator to get cells as a source of DNA material to look for mutations in the Filaggrin gene, one of the causes of eczema.
- #16 Atopic Dermatitis Diagnosis & Evaluation | Clinical Guidancehttps://www.healio.com/clinical-guidance/atopic-dermatitis/diagnosis-and-evaluation-diagnosis
During diagnosis, AD should be differentiated from a variety of other causes of cutaneous inflammation. […] Biomarkers can be used for a variety of purposes, including confirmation of clinical diagnosis, objective measures of disease severity, and prediction of treatment response. However, there are currently no biomarkers that accurately reflect the severity of AD or its symptoms, or distinguish AD from other diseases. As such, the diagnosis and severity assessment of AD remains clinical. […] Elevated total and/or allergen-specific serum immunoglobulin E (IgE) is the most commonly considered biomarker with AD. Although total IgE does tend to increase with disease severity, many individuals with severe AD have normal IgE levels. […] There is no gold standard for evaluating the severity of AD. Since there are no reliable laboratory tests or biomarkers to assess the severity of AD, clinicians must rely upon clinical assessments of disease parameters that can be subjective and difficult to standardize.
- #17 Atopic Dermatitis: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2020/0515/p590.html
The Scoring Atopic Dermatitis index is the most widely used validated clinical tool to classify atopic dermatitis severity based on the affected body area and intensity of lesion characteristics. […] Testing for food and environmental allergies is not recommended because of the high rate of false positives leading to unnecessary food avoidance.
- #18 Eczema | Causes, Symptoms & Treatment | ACAAI Public Websitehttps://acaai.org/allergies/allergic-conditions/skin-allergy/eczema/
Eczema, also called atopic dermatitis, is a skin disease that causes an itchy rash. […] Eczema, also known as âatopic dermatitis,â is a noncontagious, inflammatory skin condition that is characterized by severe itching, redness, oozing, and scaly rashes. […] Children and adults diagnosed with eczema can manage the condition with the guidance of an allergist. […] Allergists are specially trained to treat skin conditions, such as eczema, which are often related to an allergic response. […] Your allergist may perform a prick test, which involves a diluted allergen being applied with a prick or a puncture on the surface of the skin. […] An allergistâs specialized training helps them to develop a treatment plan for your individual condition. […] From 33 to 63 percent of young children with moderate to severe eczema also have food allergies.
- #19 Dermatitis – Diagnosis and treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/dermatitis-eczema/diagnosis-treatment/drc-20352386
To diagnose dermatitis, your doctor will likely look at your skin and talk with you about your symptoms and medical history. You may need to have a small piece of skin removed for study in a lab, which helps rule out other conditions. This procedure is called a skin biopsy. […] Your doctor may suggest a patch test to identify the cause of your symptoms. In this test, small amounts of potential allergens are put on sticky patches. Then the patches are placed on your skin. They stay on your skin for 2 to 3 days. During this time, you’ll need to keep your back dry. Then your health care provider checks for skin reactions under the patches and determines whether further testing is needed.
- #20 Atopic dermatitis – Symptoms, diagnosis and treatment | BMJ Best Practice UShttps://bestpractice.bmj.com/topics/en-us/87?locale=no
Atopic dermatitis (eczema) commonly presents with dry, itchy skin. […] Diagnosis is primarily clinical. […] Key diagnostic factors include pruritus, xerosis (dry skin), and sites of skin involvement. […] Other diagnostic factors include erythema, scaling, vesicles, papules, keratosis pilaris, excoriations, lichenification, and hypopigmentation. […] 1st tests to order include clinical diagnosis. […] Investigations to avoid include IgG testing and radioallergosorbent test. […] Tests to consider include IgE levels, skin-prick testing, oral food challenge, trial elimination diet, patch testing, and skin biopsy.
- #21 Eczema | Causes, Symptoms & Treatment | ACAAI Public Websitehttps://acaai.org/allergies/allergic-conditions/skin-allergy/eczema/
It is recommended that children under the age of 5 who have moderate to severe eczema be evaluated for milk, egg, peanut, wheat, and soy allergies, if the child continues to have eczema even after treatment. […] Recent guidelines put infants who have severe eczema and/or egg allergy in the highest risk category for peanut allergy. […] Allergists are specially trained to help you take control of your eczema, so you can live the life you want.
- #22 Atopic Dermatitis Diagnosis & Evaluation | Clinical Guidancehttps://www.healio.com/clinical-guidance/atopic-dermatitis/diagnosis-and-evaluation-diagnosis
Given the increasing number of outcome measures developed for AD, the Harmonizing Outcome Measures in Eczema (HOME) international consensus group was assembled to promote the standardization of use of AD outcome measures in clinical trials internationally. […] The SCORAD was inaugurated in 1993 by the European Task Force on AD, and is the most commonly used objective assessment in RCTs for AD. […] The Eczema Area and Severity Index (EASI) was developed as a modification of the well-established Psoriasis Area and Severity Index (PASI). […] The POEM, developed in 2004, was designed as a patient-reported outcome to measure frequency of AD activity. […] The DLQI tool, developed in 1994, is one of the most commonly used assessments in dermatology and clinical trials. […] The DFI, developed in 1998, assesses the extent of how a child with AD affects the QOL of the childâs family.
- #23 Guidelines for the diagnosis and assessment of eczemahttps://dermnetnz.org/topics/guidelines-for-the-diagnosis-and-assessment-of-eczema
Eczema is a chronic inflammatory skin disease that affects about 20% of children and 3% of adults. It is characterized by pruritus, scratching, and eczematous lesions (dry, scaling and crusted areas of skin), and when chronic may be associated with lichenification (thickening) and pigmentary changes. Eczema is also known as atopic eczema, or atopic dermatitis (eczema). […] The diagnosis of eczema is based on patient history and clinical/physical examination. Features to consider when making a diagnosis are summarized in the following tables. […] A diagnosis of eczema depends upon excluding other conditions. […] The diagnosis of eczema depends on excluding other skin conditions that may show similar features. Other diagnoses should be considered particularly when there is an atypical presentation, associated failure to thrive or inadequate response to treatment. […] In some instances investigations may be needed to confirm the diagnosis of eczema and rule out other diagnoses.
- #24 Atopic Dermatitis (Eczema) – Dermatologic Disorders – Merck Manual Professional Editionhttps://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/atopic-dermatitis-eczema
Atopic dermatitis is a chronic relapsing inflammatory skin disorder with a complex pathogenesis involving genetic susceptibility, immunologic and epidermal barrier dysfunction, and environmental factors. […] Diagnosis of atopic dermatitis is clinical. History (eg, personal or family history of asthma or allergic rhinoconjunctivitis) is helpful. […] Atopic dermatitis is sometimes difficult to differentiate from other dermatoses. The diagnosis of atopic dermatitis depends on excluding other conditions, including: Seborrheic dermatitis, Contact dermatitis (irritant or allergic), Psoriasis, Nummular dermatitis (nonatopic), Scabies, Ichthyoses, Cutaneous T-cell lymphoma, Photosensitivity dermatoses, Immune deficiency diseases, Erythroderma of other causes. […] A personal and/or family history of atopy and the distribution of lesions are helpful in making the diagnosis of atopic dermatitis.
- #25 Atopic Dermatitis (Eczema) – Dermatologic Disorders – Merck Manual Professional Editionhttps://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/atopic-dermatitis-eczema
Clues to atopic dermatitis include a flexural distribution of lesions and personal or family history of allergic rhinoconjunctivitis and asthma. […] There is no definitive laboratory test for atopic dermatitis. However, testing for type I allergies (prick, scratch, and intracutaneous testing or measurement of allergen-specific IgE levels and of total IgE levels) can help confirm an atopic diathesis. […] The following distribution patterns can also help with differentiation: Psoriasis is typically easy to recognize by its sharply demarcated, thick, erythematous, and scaly plaques. […] Erythroderma caused by atopic dermatitis can be difficult to differentiate from erythroderma caused by other skin disorders.
- #26 Atopic eczema – NHShttps://www.nhs.uk/conditions/atopic-eczema/
Atopic eczema (atopic dermatitis) is a common skin condition that causes itchy skin. It cannot be cured, but treatment can help manage the symptoms. […] Atopic eczema can make your skin: itchy, dry, cracked, crusty, scaly or thickened, red, white, purple or grey, or lighter or darker than the skin around it (depending on your skin tone), blister or bleed. […] Symptoms can start at any age, but they usually start in babies and young children and tend to get better as they get older. […] There are usually times where your symptoms get worse (called flare-ups) and times where they are better. […] Non-urgent advice: See a GP if: you or your child have symptoms of atopic eczema, treatments are not helping your atopic eczema. […] Urgent advice: Ask for an urgent GP appointment or get help from NHS 111 if: You or your child have atopic eczema and: it’s blistered, crusty, leaking fluid or has spots filled with pus, it’s painful, swollen or feels warm, it suddenly gets worse or gets bigger, you have a high temperature or feel generally unwell.
- #27 Should I See A Dermatologist or Allergist For Eczema? | Asthma and Allergy Foundation of Americahttps://community.aafa.org/db/ask-the-allergist/record/should-i-see-a-dermatologist-or-allergist-for-eczema
Both allergists and dermatologists can evaluate and treat eczema. There are some things to think about when deciding which specialist to see. […] Allergists can help identify triggers for eczema (e.g., food and environmental allergens). This can be done with a clinical history and allergy testing. They can recommend avoidance measures and environmental controls. In some cases, immunotherapy (allergy shots) can be used. This decreases the body’s immune response to allergens. […] A dermatologist can offer a skin biopsy. This is if the eczema is unusual or is not responding to common treatments. […] Both specialists may recommend skin patch testing. This can rule out allergic contact dermatitis. They can also recommend treatments. To manage difficult cases of eczema, it’s useful to see both specialists.
- #28 Atopic Dermatitis: Causes, Symptoms, Diagnosis | National Eczema Associationhttps://nationaleczema.org/eczema/types-of-eczema/atopic-dermatitis/
Atopic dermatitis is typically diagnosed during a doctor visit. This may include a visit with a primary care physician, a dermatologist and/or an allergist. Atopic dermatitis is often diagnosed with a physical examination of the symptoms based on appearance and duration. Other methods of diagnosis include a skin biopsy where a sample of the skin is taken for lab testing to rule out other skin conditions. There are no laboratory tests to confirm a diagnosis of atopic dermatitis. […] For atopic dermatitis daily management, it is important to establish a regular skincare routine that includes bathing and moisturizing to retain moisture and repair the skin barrier. Moisturized skin helps control flares by combating dryness and keeping out irritants and allergens. […] Depending on severity of symptoms and age, atopic dermatitis treatments include lifestyle changes, over-the-counter (OTC) and natural remedies, prescription topical medications, which are applied to the skin; biologics, given by injection; immunosuppressants, usually taken by mouth in the form of a pill; and phototherapy, a form of ultraviolet light treatment. Its important to discuss your treatment options with your doctor to assess what works best for you.
- #29 Diagnostic Criteria for Atopic Dermatitis (Eczema) | Time of Carehttps://www.timeofcare.com/diagnostic-criteria-for-atopic-dermatitis-eczema/
Pruritus (itchy skin) and xerosis (dry skin) are key symptoms of atopic dermatitis. If a patient doesnt have them, the diagnosis of eczema should be questioned. […] A simplified version of the U.K. Working Partys diagnostic criteria for eczema has a sensitivity of 95% and specificity of 97%. […] These criteria include itchy skin PLUS at least 3 of the following: History of generalized dry skin, History of flexural involvement, Visible flexural dermatitis, History of atopy (asthma or allergic rhinitis) personal or family history, The onset of rash before two years of age. […] Major Features (Must Have 3 or more): Pruritus (itchy skin), Typical morphology and distribution, Chronic or chronically relapsing dermatitis, Personal or family history of atopy (asthma, allergic rhinoconjunctivitis, atopic dermatitis).
- #30 Atopic Dermatitis: Symptoms, Causes & Treatmenthttps://my.clevelandclinic.org/health/diseases/24299-atopic-dermatitis
Atopic dermatitis is a chronic condition that causes skin discoloration and itchy rashes. […] Theres no cure, but you can manage it with creams and medications or other available treatment options. […] A healthcare provider will diagnose atopic dermatitis after reviewing your symptoms during a physical examination. […] In some cases, your provider may recommend a skin biopsy. This is a test to look at a sample of your skin more closely in a lab under a microscope. […] Your healthcare provider may recommend different options to treat your atopic dermatitis symptoms. […] Two medications that your provider may prescribe to treat atopic dermatitis include: Topical corticosteroids and Topical calcineurin inhibitors. […] The timeline varies from person to person after you start treatment. […] Contact a provider if you notice changes to your skin that cause pain and discomfort. […] Atopic dermatitis symptoms may come and go throughout your life. But the condition doesnt go away completely.
- #31 Eczema (atopic dermatitis) | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/conditionsandtreatments/eczema-atopic-dermatitis
New treatments recently approved for the treatment of moderate to severe atopic dermatitis include dupilumab, an injectable biologic therapy and upadacitinib a Janus Kinase inhibitor tablet. […] There is growing evidence that allergens introduced into the body through the skin can lead to the later development of food allergy, asthma and hay fever. Aggressively treating eczema in children and taking steps to restore normal skin barrier function may lower the risk of future development of these conditions.