Rumień nagły
Etiologia i przyczyny

Rumień nagły (exanthem subitum) to wirusowa choroba wieku dziecięcego, wywoływana głównie przez ludzki herpeswirus typu 6B (HHV-6B) oraz rzadziej HHV-7, należące do rodziny Herpesviridae. Charakteryzuje się nagłym początkiem wysokiej gorączki (okres wylęgania 5-15 dni), po której ustąpieniu pojawia się różowa, drobnoplamista wysypka. Zakażenie przenosi się drogą kropelkową i przez kontakt bezpośredni, a dziecko jest najbardziej zakaźne w fazie gorączki, przed wysypką. Choroba dotyczy głównie niemowląt i małych dzieci w wieku 6 miesięcy do 2 lat, z szczytem zachorowań między 7 a 13 miesiącem życia. Po przebyciu zakażenia rozwija się zwykle trwała odporność, a ponowne zachorowania są rzadkie, choć możliwe, zwłaszcza u osób z immunosupresją.

Rumień nagły (Roseola) – Etiologia, przyczyny zachorowania

Rumień nagły (roseola infantum, łac. exanthem subitum, szósta choroba) jest chorobą wirusową, występującą głównie u niemowląt i małych dzieci. Choroba ta charakteryzuje się nagłą wysoką gorączką, po której ustąpieniu pojawia się charakterystyczna różowa wysypka.12

Czynnik zakaźny

Głównym czynnikiem etiologicznym rumienia nagłego jest ludzki herpeswirus typu 6 (HHV-6), a rzadziej ludzki herpeswirus typu 7 (HHV-7).12 Wirusy te należą do rodziny Herpesviridae i rodzaju Roseolovirus w podrodzinie Betaherpesvirinae.3 Chociaż należą one do tej samej rodziny co wirusy opryszczki pospolitej (HSV), nie powodują opryszczki wargowej ani zakażeń narządów płciowych.45

W przypadku HHV-6 wyróżnia się dwa warianty: A i B. To przede wszystkim wariant HHV-6B odpowiada za wywoływanie rumienia nagłego.67 HHV-6 jest blisko spokrewniony z ludzkim cytomegalowirusem (HCMV) oraz HHV-7.8

Rzadziej rumień nagły może być wywoływany przez inne wirusy, takie jak:910

Mechanizm transmisji zakażenia

Rumień nagły jest chorobą zakaźną, która rozprzestrzenia się głównie drogą kropelkową i przez kontakt bezpośredni.1112 Transmisja zakażenia może następować poprzez:

  • Wydzieliny z dróg oddechowych – gdy osoba zakażona kaszle, kicha lub mówi, wydziela kropelki zawierające wirusa do powietrza, które mogą być wdychane przez innych1314
  • Kontakt ze śliną – wirus może być przenoszony przez bezpośredni kontakt ze śliną osoby zakażonej1516
  • Kontakt pośredni – kropelki mogą osiadać na powierzchniach, takich jak blaty czy zabawki, skąd mogą być przenoszone na ręce, a następnie do ust lub nosa, powodując zakażenie17

Co istotne, osoba zakażona może przenosić wirusa, zanim jeszcze wystąpią u niej objawy choroby.1819 Dziecko jest najbardziej zakaźne w fazie wysokiej gorączki, przed pojawieniem się wysypki.20 Okres wylęgania choroby (czas od zakażenia do wystąpienia objawów) wynosi od 5 do 15 dni.2122

Epidemiologia

Rumień nagły jest powszechną chorobą dziecięcą o globalnym zasięgu.23 Większość przypadków dotyczy dzieci w wieku od 6 miesięcy do 2 lat życia, przy czym szczyt zachorowań przypada między 7 a 13 miesiącem życia.2425 Około 90% przypadków rumienia nagłego występuje u dzieci poniżej 2. roku życia.26

Szacuje się, że do 2. roku życia około 95% dzieci przechodzi zakażenie wirusem HHV-6.27 Większość dzieci ma kontakt z tym wirusem przed ukończeniem 4. roku życia.28 Choroba może występować przez cały rok, choć niektóre źródła wskazują na częstsze występowanie wiosną i jesienią.29

Czynniki ryzyka

Główne czynniki ryzyka zachorowania na rumień nagły obejmują:3031

  • Wiek – najwyższe ryzyko dotyczy dzieci w wieku 6 miesięcy – 2 lata
  • Brak wcześniejszej ekspozycji na wirusa (brak odporności)
  • Niedojrzały układ odpornościowy – niemowlęta i małe dzieci mają rozwijający się układ immunologiczny, co czyni je bardziej podatnymi na zakażenia
  • Bliski kontakt z osobą zakażoną (członek rodziny, opiekun)

Patogeneza

Po wniknięciu do organizmu, wirus HHV-6 lub HHV-7 namnaża się w śluzówce dróg oddechowych, po czym rozprzestrzenia się drogą krwionośną (wiremia), co prowadzi do wystąpienia gorączki. Wirus może przyłączać się do gruczołów ślinowych i tkanki mózgowej, pozostając w organizmie nawet po ustąpieniu objawów rumienia nagłego.32

Zarówno HHV-6, jak i HHV-7 mogą pozostawać w organizmie w postaci latentnej po pierwotnym zakażeniu. W niektórych przypadkach zakażenie HHV-7 może reaktywować latentne zakażenie HHV-6.33 U osób z prawidłową odpornością rzadko dochodzi do reaktywacji zakażenia.34

Nawroty choroby

Ponowne zachorowanie na rumień nagły jest rzadkie, ponieważ po przebyciu choroby zazwyczaj rozwija się odporność na wirusa.3536 Istnieją jednak udokumentowane przypadki ponownego zachorowania, jak na przykład przypadek 13-miesięcznego dziecka, u którego wystąpił drugi epizod rumienia nagłego.37

Wyjątek stanowią osoby z obniżoną odpornością (immunosupresja, immunokompromitacja), u których może dojść do ponownego zachorowania lub reaktywacji wirusa z ciężkim przebiegiem klinicznym.3839

Potencjalne powikłania związane z etiologią

Choć rumień nagły jest zazwyczaj łagodną chorobą, zakażenie HHV-6 może w rzadkich przypadkach prowadzić do poważniejszych powikłań, w tym:404142

U osób z obniżoną odpornością reaktywacja wirusa HHV-6 może prowadzić do gorączki, wysypki, zapalenia płuc, zapalenia wątroby, supresji szpiku kostnego i zapalenia mózgu.43

Rzadko rumień nagły może wywoływać zespół podobny do mononukleozy, charakteryzujący się znacznym powiększeniem węzłów chłonnych, wątroby i śledziony, który występował zarówno u niemowląt, jak i dorosłych.44

Diagnostyka etiologiczna

Diagnoza rumienia nagłego zazwyczaj opiera się na obrazie klinicznym – charakterystycznym przebiegu z wysoką gorączką, po której ustąpieniu pojawia się wysypka. W większości przypadków nie ma potrzeby wykonywania badań laboratoryjnych w celu potwierdzenia zakażenia.45

W niektórych sytuacjach, zwłaszcza w przypadkach nietypowych lub powikłanych, zakażenie HHV-6 można potwierdzić za pomocą:4647

Profilaktyka zakażenia

Obecnie nie istnieje szczepionka przeciwko wirusom wywołującym rumień nagły (HHV-6 i HHV-7).4849 Zapobieganie zakażeniu jest trudne, ponieważ wirus jest zakaźny jeszcze przed pojawieniem się objawów.50

Środki zapobiegawcze, które mogą pomóc ograniczyć rozprzestrzenianie się wirusa, obejmują:5152

  • Dokładne i regularne mycie rąk
  • Unikanie bliskiego kontaktu z osobami zakażonymi
  • Przestrzeganie zasad higieny podczas kaszlu i kichania
  • Dezynfekcja powierzchni i przedmiotów, które mogły mieć kontakt z wydzielinami osoby zakażonej

Należy podkreślić, że ze względu na powszechność wirusa i fakt, że jest on zakaźny przed wystąpieniem objawów, całkowite zapobieganie zakażeniom jest praktycznie niemożliwe.53

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Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Roseola Infantum – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK448190/
    Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequently, by human herpesvirus 7 (HHV-7). […] Roseola infantum is most commonly caused by human herpesvirus 6 and less commonly, human herpesvirus 7. Human herpesvirus 6 has two variants: A and B. The primary variant that causes roseola infantum is HHV-6B. […] Human herpesvirus 6, a virus found in the Herpesviridae family, causes roseola infantum. HHV-6 is a betaherpesvirus, closely related to human cytomegalovirus (HCMV) and human herpesvirus 7 (HHV-7).
  • #1 Roseola (Sixth Disease) Symptoms & Causes
    https://my.clevelandclinic.org/health/diseases/15785-roseola-infantumsixth-disease
    Roseola is a viral infection, meaning your child is exposed to a virus that makes them sick. The human herpesvirus 6 causes most cases of roseola. The human herpesvirus 7 causes a few cases. […] Yes, roseola is contagious. It spreads through the saliva and respiratory droplets (from a cough or sneeze) of someone who has a fever or doesn’t yet have symptoms. It takes anywhere from five to 15 days for symptoms to start after exposure to a virus that causes roseola.
  • #2 Roseola (Sixth Disease)
    https://www.healthline.com/health/roseola
    Roseola also known as sixth disease is a contagious illness caused by a virus. […] Roseola is a viral illness that is usually caused by exposure to the human herpesvirus (HHV) type 6 or 7. […] In most cases, roseola causes a high fever for a few days followed by a signature rash.
  • #2 Roseola Infantum – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK448190/
    Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequently, by human herpesvirus 7 (HHV-7). […] Roseola infantum is most commonly caused by human herpesvirus 6 and less commonly, human herpesvirus 7. Human herpesvirus 6 has two variants: A and B. The primary variant that causes roseola infantum is HHV-6B. […] Human herpesvirus 6, a virus found in the Herpesviridae family, causes roseola infantum. HHV-6 is a betaherpesvirus, closely related to human cytomegalovirus (HCMV) and human herpesvirus 7 (HHV-7).
  • #3 Roseola Infantum: Practice Essentials, Background, Pathophysiology
    https://emedicine.medscape.com/article/1133023-overview
    Roseola infantum is a viral illness that occurs secondary to human herpesvirus (HHV)-6 or HHV-7 infection. […] Roseola is a common childhood disease, caused by primary infection with human herpesvirus 6 (HHV-6). […] The causative agent of roseola infantum, HHV-6, was discovered in 1986. The Roseolovirus genus of the Betaherpesvirinae subfamily contains HHV-6 and HHV-7. […] HHV-6B is the cause of roseola in infants. […] HHV-7 has been identified in a few cases of roseola infantum. […] Recurrences of roseola infantum are not common. A well-documented case of a 13-month-old child who had a second episode of roseola exists.
  • #4 Roseola (for Parents) | Nemours KidsHealth
    https://kidshealth.org/en/parents/roseola.html
    Roseola (roe-zee-OH-lah) is a viral illness that most commonly affects kids between 6 months and 2 years old. […] Two common, closely related viruses can cause roseola: human herpesvirus (HHV) type 6 and type 7. These viruses belong to the same family as the better-known herpes simplex viruses (HSV), but do not cause the cold sores and genital herpes infections that HSV can cause.
  • #5 Roseola Rash, Causes, Symptoms, Treatment & Contagious
    https://www.emedicinehealth.com/roseola/article_em.htm
    Roseola is primarily caused by a virus called human herpesvirus 6 (HHV-6) and less commonly by human herpesvirus 7 (HHV-7). […] Roseola is primarily caused by a virus called human herpesvirus 6 (HHV-6) and less commonly by human herpesvirus 7 (HHV-7). […] Roseola is primarily caused by a virus called human herpesvirus 6 (HHV-6) and less commonly by human herpesvirus 7 (HHV-7). These viruses are different from the viruses that cause genital herpes and cold sores, although they belong to the same family of viruses. […] While roseola is spread from person to person, the exact mechanism of transmission is not well defined. […] Experts postulate that respiratory secretions are most likely involved. […] The incubation period between virus exposure and the onset of symptoms (fever, etc.) is nine to 10 days.
  • #6 Roseola Infantum – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK448190/
    Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequently, by human herpesvirus 7 (HHV-7). […] Roseola infantum is most commonly caused by human herpesvirus 6 and less commonly, human herpesvirus 7. Human herpesvirus 6 has two variants: A and B. The primary variant that causes roseola infantum is HHV-6B. […] Human herpesvirus 6, a virus found in the Herpesviridae family, causes roseola infantum. HHV-6 is a betaherpesvirus, closely related to human cytomegalovirus (HCMV) and human herpesvirus 7 (HHV-7).
  • #7 Roseola Infantum: Practice Essentials, Background, Pathophysiology
    https://emedicine.medscape.com/article/1133023-overview
    Roseola infantum is a viral illness that occurs secondary to human herpesvirus (HHV)-6 or HHV-7 infection. […] Roseola is a common childhood disease, caused by primary infection with human herpesvirus 6 (HHV-6). […] The causative agent of roseola infantum, HHV-6, was discovered in 1986. The Roseolovirus genus of the Betaherpesvirinae subfamily contains HHV-6 and HHV-7. […] HHV-6B is the cause of roseola in infants. […] HHV-7 has been identified in a few cases of roseola infantum. […] Recurrences of roseola infantum are not common. A well-documented case of a 13-month-old child who had a second episode of roseola exists.
  • #8 Roseola Infantum – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK448190/
    Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequently, by human herpesvirus 7 (HHV-7). […] Roseola infantum is most commonly caused by human herpesvirus 6 and less commonly, human herpesvirus 7. Human herpesvirus 6 has two variants: A and B. The primary variant that causes roseola infantum is HHV-6B. […] Human herpesvirus 6, a virus found in the Herpesviridae family, causes roseola infantum. HHV-6 is a betaherpesvirus, closely related to human cytomegalovirus (HCMV) and human herpesvirus 7 (HHV-7).
  • #9 Roseola Infantum
    https://mobile.fpnotebook.com/ID/Virus/RslInfntm.htm
    Human Herpes Virus (Herpesviridae) […] Human Herpes Virus (HHV) Type 6 (most common) […] Other viruses may, less commonly, cause a similar presentation […] HHV 7 […] Enterovirus […] Coxsackievirus […] Adenovirus […] Parainfluenza VIrus.
  • #10 Roseola causes – wikidoc
    https://www.wikidoc.org/index.php/Roseola_causes
    Roseola may be caused by either Human herpes virus 6A, 6B and 7 (HHV6A, HHV6B and HHV 7). The most common cause is HHV6B. Other causes include enteroviruses (Coxsackie A and B, echoviruses), adenoviruses and parainfluenza viruses. […] Roseola may be caused by Human herpes virus 6A, 6B and 7 (HHV6A, HHV6B and HHV 7). Other causes include enteroviruses (Coxsackie A and B, echoviruses), adenoviruses and parainfluenza viruses. […] HHV-6B causes exanthema subitum.
  • #11 Roseola (Sixth Disease) Symptoms & Causes
    https://my.clevelandclinic.org/health/diseases/15785-roseola-infantumsixth-disease
    Roseola is a viral infection, meaning your child is exposed to a virus that makes them sick. The human herpesvirus 6 causes most cases of roseola. The human herpesvirus 7 causes a few cases. […] Yes, roseola is contagious. It spreads through the saliva and respiratory droplets (from a cough or sneeze) of someone who has a fever or doesn’t yet have symptoms. It takes anywhere from five to 15 days for symptoms to start after exposure to a virus that causes roseola.
  • #12 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #13 Roseola in Children
    https://encyclopedia.nm.org/Conditions/Neuroscience/90,P02539
    Roseola is caused by a type of herpes virus. […] The virus can enter the body through the nose and mouth. […] It is spread when a child breathes in droplets that contain the virus after an infected person coughs, sneezes, talks, or laughs.
  • #14 When Your Child Has Roseola | Saint Luke’s Health System
    https://www.saintlukeskc.org/health-library/when-your-child-has-roseola
    Roseola is most often caused by a virus in the human herpes virus family. […] It is spread by droplets in the air when an infected person sneezes or coughs.
  • #15
    https://www.anticoagulationeurope.org/conditions/roseola/
    Roseola is caused by the human herpesvirus 6 (HHV-6). […] It is still unknown how the disease is spread but it may be present in saliva. The incubation period is 5 to 15 days.
  • #16 Roseola infantum | Better Health Channel
    https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/roseola-infantum
    Roseola is caused by one of the viruses in the herpes group, but this virus cant cause other herpes infections, such as cold sores. […] It is not known how the virus is spread, although spread via saliva is suspected. […] Most children have been in contact with this virus by the time they are three years old.
  • #17 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #18 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #19 Roseola in Children
    https://metropolitanocr.staywellsolutionsonline.com/coronavirus/90,P02539
    Roseola is a contagious viral illness. It causes a high fever and then a rash that develops as the fever goes away. […] Roseola is caused by a type of herpes virus. The virus can enter the body through the nose and mouth. It is spread when a child breathes in droplets that contain the virus after an infected person coughs, sneezes, talks, or laughs. […] It most commonly affects children younger than age 2. […] A child is most contagious during the high fever, before the rash occurs. […] The goal of treatment is to help reduce symptoms.
  • #20 Roseola in Children
    https://metropolitanocr.staywellsolutionsonline.com/coronavirus/90,P02539
    Roseola is a contagious viral illness. It causes a high fever and then a rash that develops as the fever goes away. […] Roseola is caused by a type of herpes virus. The virus can enter the body through the nose and mouth. It is spread when a child breathes in droplets that contain the virus after an infected person coughs, sneezes, talks, or laughs. […] It most commonly affects children younger than age 2. […] A child is most contagious during the high fever, before the rash occurs. […] The goal of treatment is to help reduce symptoms.
  • #21 Roseola (Sixth Disease) Symptoms & Causes
    https://my.clevelandclinic.org/health/diseases/15785-roseola-infantumsixth-disease
    Roseola is a viral infection, meaning your child is exposed to a virus that makes them sick. The human herpesvirus 6 causes most cases of roseola. The human herpesvirus 7 causes a few cases. […] Yes, roseola is contagious. It spreads through the saliva and respiratory droplets (from a cough or sneeze) of someone who has a fever or doesn’t yet have symptoms. It takes anywhere from five to 15 days for symptoms to start after exposure to a virus that causes roseola.
  • #22 Roseola | Texas Children’s
    https://www.texaschildrens.org/content/conditions/roseola
    Roseola is a contagious viral illness that results in a high fever and a rash that develops as the fever resolves. […] Roseola is a syndrome that can be caused by several common viruses. […] It may take between 5 to 15 days for a child to develop symptoms of roseola after being exposed to the virus.
  • #23 Roseola Infantum – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK448190/
    Roseola infantum is a common disease of childhood that is seen globally and is caused by infection with human herpesvirus 6 (HHV-6), or, less frequently, by human herpesvirus 7 (HHV-7). […] Roseola infantum is most commonly caused by human herpesvirus 6 and less commonly, human herpesvirus 7. Human herpesvirus 6 has two variants: A and B. The primary variant that causes roseola infantum is HHV-6B. […] Human herpesvirus 6, a virus found in the Herpesviridae family, causes roseola infantum. HHV-6 is a betaherpesvirus, closely related to human cytomegalovirus (HCMV) and human herpesvirus 7 (HHV-7).
  • #24 Roseola infantum (exanthem subitum) – UpToDate
    https://www.uptodate.com/contents/roseola-infantum-exanthem-subitum
    Roseola infantum (also known as exanthem subitum, sixth disease, pseudorubella, exanthem criticum, and three-day fever) is caused by the B variant of human herpesvirus 6 (HHV-6). […] Human herpesvirus 6B (HHV-6B) is the most frequent cause of roseola. Other causes include HHV-7, enteroviruses (coxsackieviruses A and B, echoviruses), adenoviruses, and parainfluenza virus type 1. […] Roseola is an illness of young children, with a peak prevalence between 7 and 13 months. Ninety percent of cases occur in children younger than two years.
  • #25 Roseola (for Parents) | Nemours KidsHealth
    https://kidshealth.org/en/parents/roseola.html
    Roseola (roe-zee-OH-lah) is a viral illness that most commonly affects kids between 6 months and 2 years old. […] Two common, closely related viruses can cause roseola: human herpesvirus (HHV) type 6 and type 7. These viruses belong to the same family as the better-known herpes simplex viruses (HSV), but do not cause the cold sores and genital herpes infections that HSV can cause.
  • #26 Roseola infantum (exanthem subitum) – UpToDate
    https://www.uptodate.com/contents/roseola-infantum-exanthem-subitum
    Roseola infantum (also known as exanthem subitum, sixth disease, pseudorubella, exanthem criticum, and three-day fever) is caused by the B variant of human herpesvirus 6 (HHV-6). […] Human herpesvirus 6B (HHV-6B) is the most frequent cause of roseola. Other causes include HHV-7, enteroviruses (coxsackieviruses A and B, echoviruses), adenoviruses, and parainfluenza virus type 1. […] Roseola is an illness of young children, with a peak prevalence between 7 and 13 months. Ninety percent of cases occur in children younger than two years.
  • #27 Roseola infantum
    https://www.rch.org.au/kidsinfo/fact_sheets/roseola_infantum/
    Roseola infantum is a common, mild, viral infection that can cause a temperature and rash in babies and young children. It is caused by a virus from the herpes group, but it does not cause other herpes infections like cold sores. […] Roseola is contagious before the symptoms appear, so it is difficult to prevent its spread to others. […] There is no known way to prevent the spread of roseola and there is no vaccine. […] Roseola is contagious, but only before the symptoms appear. […] By the age of two years, 95 per cent of people have been infected with roseola.
  • #28 Roseola | Symptoms, Causes & Treatment
    https://www.cincinnatichildrens.org/health/r/roseola
    Roseola is caused by a virus (human herpes virus 6, or HHHV-6). […] Most children have usually been affected by this virus by the time they are 4 years of age. […] Infants and children are believed to catch the virus from close contact with a family member or caregiver who passes the virus but has no symptoms.
  • #29 Roseola | Boston Children’s Hospital
    https://www.childrenshospital.org/conditions/roseola
    Roseola is caused by many viruses. The most common cause is the human herpes virus-6 virus. It occurs mostly in children under the age of 3. […] Roseola is contagious, although the way it is spread is unknown. It occurs mostly in the spring and fall.
  • #30 Roseola: Understanding Symptoms, Causes, and Treatment • Yesil Health
    https://yesilhealth.com/your-health/roseola-understanding-symptoms-causes-and-treatment/
    Roseola, also known as roseola infantum, is a common viral infection that primarily affects young children, typically between the ages of 6 months and 2 years. This illness is caused by human herpesvirus 6 (HHV-6) and, less commonly, human herpesvirus 7 (HHV-7). […] The main cause of roseola is a viral infection, most commonly attributed to two types of human herpes viruses: Human Herpesvirus 6 (HHV-6) and Human Herpesvirus 7 (HHV-7). These viruses are part of the herpes virus family and are highly contagious. […] Young children have developing immune systems, making them more susceptible to infections like roseola. […] As children grow older, they typically develop immunity to these viruses through previous infections or vaccinations. However, infants who have not yet been exposed to HHV-6 or HHV-7 are at a higher risk.
  • #31 Roseola: Causes, Symptoms, Diagnosis, and Treatment – DoveMed
    https://prod.cluster.dovemed.com/health-topics/focused-health-topics/roseola-causes-symptoms-diagnosis-and-treatment
    Roseola, also known as sixth disease, is a common viral infection in young children, typically characterized by a sudden high fever followed by a distinctive rash as the fever subsides. Caused by human herpesvirus 6 (HHV-6) and occasionally by human herpesvirus 7 (HHV-7), roseola primarily affects children aged 6 months to 2 years. […] Primarily caused by human herpesvirus 6 (HHV-6) and less commonly by human herpesvirus 7 (HHV-7). […] Young children are more susceptible due to their developing immune systems. […] Spread through respiratory secretions or saliva, often from caregivers to children.
  • #32 Roseola rash: symptoms, pictures, and treatment
    https://www.medicalnewstoday.com/articles/roseola-rash
    Roseola results from infection with one of two main strains of the human herpesvirus (HHV): HHV-6 or HHV-7. […] After infection, HHV-6 or HHV-7 attach to the salivary glands and brain tissue, remaining in the body after the baby or toddler recovers from roseola symptoms. […] Most herpes viruses, including those that cause roseola, transmit person-to-person through direct contact with someone who is infected. […] Unlike roseola, which is caused by the HHV-6 or HHV-7 viruses, measles (or rubeola) results from the measles virus. […] HHV-6 infection has been associated with: inflammation of heart muscle tissue, death of muscle fibers, which may lead to kidney failure, thrombocytopenia, or a low blood platelet count, Guillain-Barr syndrome, hepatitis.
  • #33 Roseola – Wikipedia
    https://en.wikipedia.org/wiki/Roseola
    Roseola, also known as sixth disease, is an infectious disease caused by certain types of human herpes viruses. […] It is caused by human herpesvirus 6 (HHV-6A, HHV-6B) or human herpesvirus 7 (HHV-7). […] There are nine known human herpesviruses. Of these, roseola has been linked to two: human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), which are sometimes referred to collectively as Roseolovirus. […] HHV-6 has been further classified into HHV-6A and HHV-6B, two distinct viruses that share 88% of the same DNA makeup, with HHV-6B the most common cause of roseola. […] Roseola caused by HHV-7 has been linked to the ability of HHV-7 infection to reactivate latent HHV-6. […] HHV-6 is thought to be transmitted from previously exposed or infected adults to young children by shedding the virus through saliva.
  • #34 Roseola | 5-Minute Clinical Consult
    https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688864/all/Roseola
    Omnipresent infection occurring in infancy and childhood; majority of cases are caused by human herpesvirus 6 (HHV-6); may be associated with other diseases including encephalitis […] Majority of cases (60-74%) due to HHV-6 […] Primary infection typically through respiratory droplets or saliva […] Congenital infection/vertical transmission occurs in 1% of cases (1). […] Lifelong latent or persistent asymptomatic infection occurs after primary infection (1). […] 80-90% of population intermittently sheds HHV-6/HHV-7 in saliva (2).
  • #35 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #36 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Roseola-Symptoms-Causes-and-Treatment.aspx
    Roseola is a viral infection affecting young children. […] The virus that causes Roseola is called Human Herpes Virus 6 or HHV-6. It belongs to the Herpes Simplex Virus family. […] Once infected by the virus, the toddler will usually develop an immunity to it. Roseola seldom affects the toddler twice. […] For immunocompetent toddlers who have a normal immune response, Roseola is a once-in-a-lifetime infection. They develop an immunity to the virus after recovering from the infection and never get it again. […] Those who are immunosuppressed, and have a weakened immune system may have complications during the infection.
  • #37 Roseola Infantum: Practice Essentials, Background, Pathophysiology
    https://emedicine.medscape.com/article/1133023-overview
    Roseola infantum is a viral illness that occurs secondary to human herpesvirus (HHV)-6 or HHV-7 infection. […] Roseola is a common childhood disease, caused by primary infection with human herpesvirus 6 (HHV-6). […] The causative agent of roseola infantum, HHV-6, was discovered in 1986. The Roseolovirus genus of the Betaherpesvirinae subfamily contains HHV-6 and HHV-7. […] HHV-6B is the cause of roseola in infants. […] HHV-7 has been identified in a few cases of roseola infantum. […] Recurrences of roseola infantum are not common. A well-documented case of a 13-month-old child who had a second episode of roseola exists.
  • #38 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #39 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Roseola-Symptoms-Causes-and-Treatment.aspx
    Roseola is a viral infection affecting young children. […] The virus that causes Roseola is called Human Herpes Virus 6 or HHV-6. It belongs to the Herpes Simplex Virus family. […] Once infected by the virus, the toddler will usually develop an immunity to it. Roseola seldom affects the toddler twice. […] For immunocompetent toddlers who have a normal immune response, Roseola is a once-in-a-lifetime infection. They develop an immunity to the virus after recovering from the infection and never get it again. […] Those who are immunosuppressed, and have a weakened immune system may have complications during the infection.
  • #40 Roseola rash: symptoms, pictures, and treatment
    https://www.medicalnewstoday.com/articles/roseola-rash
    Roseola results from infection with one of two main strains of the human herpesvirus (HHV): HHV-6 or HHV-7. […] After infection, HHV-6 or HHV-7 attach to the salivary glands and brain tissue, remaining in the body after the baby or toddler recovers from roseola symptoms. […] Most herpes viruses, including those that cause roseola, transmit person-to-person through direct contact with someone who is infected. […] Unlike roseola, which is caused by the HHV-6 or HHV-7 viruses, measles (or rubeola) results from the measles virus. […] HHV-6 infection has been associated with: inflammation of heart muscle tissue, death of muscle fibers, which may lead to kidney failure, thrombocytopenia, or a low blood platelet count, Guillain-Barr syndrome, hepatitis.
  • #41 Roseola (viral rash): Causes, Symptoms, and Treatment — DermNet
    https://dermnetnz.org/topics/roseola
    Roseola is a disease caused by the human herpes virus type 6B (HHV-6B) and possibly type 7 (HHV-7). […] Some laboratories can confirm HHV-6 infection by serology or polymerase chain reaction (PCR). […] Reactivation of HHV-6 in immune suppressed patients or in association with drug hypersensitivity syndrome results in fever, rash, pneumonia, hepatitis, bone marrow suppression and encephalitis.
  • #42 Roseola – symptoms, Definition, Demographics, Causes and symptoms, Diagnosis, Treatment, Prognosis
    http://www.healthofchildren.com/R/Roseola.html
    About 85 percent of the time, roseola is caused by a virus called human herpesvirus 6 (HHV-6). […] HHV-6 is believed to be passed between people via infected saliva. […] Very rarely, roseola causes more serious disease. Patients so afflicted experience significant swelling of the lymph nodes, the liver, and the spleen. […] This syndrome (called a mononucleosis-like syndrome, after the disease mononucleosis that causes many of the same symptoms) has occurred in both infants and adults.
  • #43 Roseola (viral rash): Causes, Symptoms, and Treatment — DermNet
    https://dermnetnz.org/topics/roseola
    Roseola is a disease caused by the human herpes virus type 6B (HHV-6B) and possibly type 7 (HHV-7). […] Some laboratories can confirm HHV-6 infection by serology or polymerase chain reaction (PCR). […] Reactivation of HHV-6 in immune suppressed patients or in association with drug hypersensitivity syndrome results in fever, rash, pneumonia, hepatitis, bone marrow suppression and encephalitis.
  • #44 Roseola – symptoms, Definition, Demographics, Causes and symptoms, Diagnosis, Treatment, Prognosis
    http://www.healthofchildren.com/R/Roseola.html
    About 85 percent of the time, roseola is caused by a virus called human herpesvirus 6 (HHV-6). […] HHV-6 is believed to be passed between people via infected saliva. […] Very rarely, roseola causes more serious disease. Patients so afflicted experience significant swelling of the lymph nodes, the liver, and the spleen. […] This syndrome (called a mononucleosis-like syndrome, after the disease mononucleosis that causes many of the same symptoms) has occurred in both infants and adults.
  • #45 Herpes Virus Type 6 (Roseola) – MD Searchlight
    https://mdsearchlight.com/child-health/herpes-virus-type-6-roseola/
    Roseola infantum is caused by this type of virus. […] HHV-6B is the cause of a common childhood illness called roseola infantum. […] It’s well known that HHV-6 is the primary cause of roseola in young children, a common sickness with high fever and rash. […] HHV-6B primarily affects infants and is often reactivated in adults, regardless of their immune status. […] A type of HHV-6, known as HHV-6B, causes a common childhood illness known as exanthema subitum or roseola infantum. […] Roseola infantum is typically diagnosed based on its symptoms. […] In children, an illness called roseola infantum, which causes a fever and a rash, is usually caused by the HHV-6 virus. […] HHV-6 infections in children with a healthy immune system typically resolve on their own and don’t require treatment. […] The most frequent problem related to this infection is known as roseola infantum, which can cause seizures triggered by high fevers. […] The HHV-6 virus is widespread globally.
  • #46 Roseola (viral rash): Causes, Symptoms, and Treatment — DermNet
    https://dermnetnz.org/topics/roseola
    Roseola is a disease caused by the human herpes virus type 6B (HHV-6B) and possibly type 7 (HHV-7). […] Some laboratories can confirm HHV-6 infection by serology or polymerase chain reaction (PCR). […] Reactivation of HHV-6 in immune suppressed patients or in association with drug hypersensitivity syndrome results in fever, rash, pneumonia, hepatitis, bone marrow suppression and encephalitis.
  • #47 Roseola Infantum: Causes, Symptoms and Treatment
    https://www.medicoverhospitals.in/diseases/roseola-infantum/
    Roseola Infantum, also known as sixth disease, is a viral infection caused by the human herpesvirus 6 (HHV-6) and, less commonly, by human herpesvirus 7 (HHV-7). […] Roseola Infantum spreads through respiratory droplets or direct contact with an infected person. […] In severe or unclear cases, blood tests may be conducted to confirm the presence of human herpesvirus 6 (HHV-6) or 7 (HHV-7), the viruses responsible for Roseola Infantum. […] There is no vaccine specifically for Roseola Infantum, but good hygiene practices, like handwashing, can help reduce the risk of transmission.
  • #48 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #49 Roseola infantum
    https://www.rch.org.au/kidsinfo/fact_sheets/roseola_infantum/
    Roseola infantum is a common, mild, viral infection that can cause a temperature and rash in babies and young children. It is caused by a virus from the herpes group, but it does not cause other herpes infections like cold sores. […] Roseola is contagious before the symptoms appear, so it is difficult to prevent its spread to others. […] There is no known way to prevent the spread of roseola and there is no vaccine. […] Roseola is contagious, but only before the symptoms appear. […] By the age of two years, 95 per cent of people have been infected with roseola.
  • #50 Roseola infantum
    https://www.rch.org.au/kidsinfo/fact_sheets/roseola_infantum/
    Roseola infantum is a common, mild, viral infection that can cause a temperature and rash in babies and young children. It is caused by a virus from the herpes group, but it does not cause other herpes infections like cold sores. […] Roseola is contagious before the symptoms appear, so it is difficult to prevent its spread to others. […] There is no known way to prevent the spread of roseola and there is no vaccine. […] Roseola is contagious, but only before the symptoms appear. […] By the age of two years, 95 per cent of people have been infected with roseola.
  • #51 Roseola (Rash After Fever): Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/skin-problems-and-treatments/what-is-roseola
    Roseola is an infection caused by one of two viruses. Most often, its caused by human herpesvirus 6 (HHV-6). […] Occasionally, its caused by human herpesvirus 7 (HHV-7). […] When someone who has the virus talks, coughs, or sneezes, they spread infected droplets into the air, which your child can breathe in. […] These droplets can also land on surfaces, like a tabletop or a toy, contaminating them. […] If your child touches the contaminated area and then brings their hand to their nose or mouth, they can become infected too. […] Unfortunately, it can take up to 15 days after getting infected to start showing symptoms — and someone can be contagious before they are sick. […] This is probably because once youve had roseola, its unlikely that you will get it again. […] There is an exception to the immunity though. If you have a weakened immune system (are immunosuppressed or immunocompromised), you could get roseola again. […] Unlike some other childhood diseases like measles or chickenpox that have vaccines, there is no roseola vaccine. […] The only way you can try to prevent roseola is by good and regular hand washing and avoiding people who are infected with the virus.
  • #52 Roseola: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/000968.htm
    Roseola is a viral infection that commonly affects infants and young children. It involves a pinkish-red skin rash and high fever. […] It is caused by a virus called human herpesvirus 6 (HHV-6), although similar syndromes are possible with other viruses. […] Careful handwashing can help prevent the spread of the viruses that cause roseola.
  • #53 Roseola – Kidshealth | Akron Children’s
    https://www.akronchildrens.org/kidshealth/en/parents/roseola.html
    Roseola (roe-zee-OH-lah) is a viral illness that most commonly affects kids between 6 months and 2 years old. […] Two common, closely related viruses can cause roseola: human herpesvirus (HHV) type 6 and type 7. […] Roseola is contagious. The infection spreads when a child with roseola talks, sneezes, or coughs, sending tiny droplets into the air that others can breathe in. […] There is no known way to prevent roseola.