Dystrofia fuchsa
Zapobieganie i profilaktyka

Dystrofia Fuchsa to dziedziczna, wielogenowa choroba rogówki, charakteryzująca się zmniejszoną liczbą komórek śródbłonka i postępującym pogorszeniem widzenia. Najczęstszym czynnikiem genetycznym jest ekspansja powtórzeń trinukleotydowych CTG18.1 w genie TCF4, z ryzykiem dziedziczenia na poziomie co najmniej 50%. Profilaktyka wtórna opiera się na regularnych badaniach okulistycznych, szczególnie po 50. roku życia, oraz zarządzaniu czynnikami ryzyka środowiskowego, takimi jak zaprzestanie palenia, kontrola cukrzycy, ochrona przed promieniowaniem UV i zrównoważona dieta bogata w przeciwutleniacze. Zabiegi refrakcyjne, takie jak LASIK, są przeciwwskazane, a operacje zaćmy wymagają modyfikacji procedury. Pooperacyjna opieka obejmuje unikanie urazów oka, stosowanie ochrony i ścisłą higienę oczu oraz stosowanie przepisanych kropli, unikając niesterylnych produktów i nieprzepisanych leków.

Profilaktyka dystrofii Fuchsa

Dystrofia Fuchsa to dziedziczna choroba rogówki wpływająca na warstwę śródbłonka, która charakteryzuje się zmniejszoną liczbą komórek śródbłonka i stopniowym pogorszeniem widzenia. Obecnie nie istnieje skuteczna metoda zapobiegania rozwojowi tej choroby, ponieważ ma ona podłoże genetyczne.123 Dystrofia Fuchsa jest chorobą wielogenową, a najczęstszym czynnikiem ryzyka genetycznego jest ekspansja powtórzeń trinukleotydowych CTG18.1 w genie TCF4. Osoby dotknięte chorobą mają co najmniej 50% szans na przekazanie genu swoim dzieciom.4

Modyfikacja czynników ryzyka

Chociaż nie można zapobiec dystrofii Fuchsa, możliwe jest zarządzanie pewnymi czynnikami ryzyka środowiskowego, które mogą wpływać na przebieg choroby:56

  • Zaprzestanie palenia tytoniu – badania wykazały, że osoby z 20-letnim wywiadem palenia doświadczają ponad dwukrotnie większego ryzyka wystąpienia rogówki guttata (wczesnej manifestacji dystrofii Fuchsa)7
  • Kontrola cukrzycy – u pacjentów z cukrzycą zalecana jest ścisła współpraca z lekarzem w celu kontroli poziomu cukru we krwi8
  • Ochrona oczu przed promieniowaniem UV – noszenie okularów przeciwsłonecznych może zapewnić ochronę przed szkodliwym promieniowaniem9
  • Zrównoważona dieta – spożywanie produktów bogatych w warzywa liściaste i kolorowe może mieć korzystny wpływ na zdrowie oczu1011

Interesujące jest, że wyższy wskaźnik masy ciała i waga były w niektórych badaniach związane ze zmniejszonym ryzykiem rogówki guttata, choć mechanizm tego zjawiska nie jest w pełni wyjaśniony.12

Regularne badania okulistyczne

Kluczowym elementem profilaktyki wtórnej dystrofii Fuchsa są regularne badania okulistyczne, szczególnie po ukończeniu 50. roku życia. Wczesne wykrycie choroby może umożliwić wdrożenie odpowiedniego leczenia, zanim pojawią się ból i utrata wzroku.131415

W przypadku zdiagnozowania dystrofii Fuchsa we wczesnym stadium, regularne badania kontrolne pozwalają na monitorowanie progresji choroby i dostosowanie leczenia. Takie podejście może znacząco opóźnić konieczność przeprowadzenia przeszczepu rogówki.16

Środki ostrożności dla pacjentów z dystrofią Fuchsa

Szczególne zalecenia dotyczące zabiegów okulistycznych

Pacjenci z dystrofią Fuchsa powinni być świadomi potencjalnego wpływu pewnych procedur okulistycznych na progresję choroby:1718

  • LASIK i inne zabiegi refrakcyjne – należy unikać tych zabiegów, ponieważ mogą pogorszyć stan choroby; dystrofia rogówki jest często uważana za przeciwwskazanie do elektywnej chirurgii refrakcyjnej19
  • Operacja zaćmy – wymaga specjalnych środków ostrożności u pacjentów z dystrofią Fuchsa; unikanie lub modyfikacja procedury operacji zaćmy może opóźnić konieczność przeszczepu rogówki2021

Ważne jest, aby pacjenci informowali swojego okulistę o rozpoznanej dystrofii Fuchsa przed jakimkolwiek planowanym zabiegiem okulistycznym.22

Zalecenia dla pacjentów po zabiegach chirurgicznych

Pacjenci po operacjach związanych z dystrofią Fuchsa powinni przestrzegać następujących zaleceń:23

  • Unikanie pocierania i uderzania oka
  • Stosowanie ochrony – używanie osłony ochronnej w nocy i okularów ochronnych w ciągu dnia przez co najmniej 3 miesiące po zabiegu, a najlepiej dłużej
  • Higiena oczu:
    • Unikanie spryskiwania oka wodą z kranu podczas kąpieli
    • Unikanie czyszczenia oka niesterylnymi produktami
    • Unikanie stosowania kosmetyków na brzegu powiek
  • Środowisko – unikanie dymu i zapylonego otoczenia
  • Stosowanie kropli do oczu:
    • Unikanie stosowania innych kropli niż przepisane przez lekarza
    • Niedotykanie końcówki butelki z kroplami podczas używania
    • Przechowywanie leku w chłodnym miejscu, najlepiej w lodówce

Objawy alarmowe wymagające pilnej konsultacji

Pacjenci powinni być świadomi objawów ostrzegawczych i niezwłocznie zgłosić się do lekarza w przypadku wystąpienia któregokolwiek z poniższych:2425

  • Uczucie ciężkości i bólu oka
  • Zaczerwienienie oka, szczególnie wokół rogówki
  • Pogorszenie ostrości wzroku
  • Nadwrażliwość na światło

Nowe podejścia terapeutyczne o potencjale profilaktycznym

Procedura DSO jako alternatywa dla przeszczepu

W ostatnich latach pojawiła się innowacyjna metoda leczenia dystrofii Fuchsa – zabieg Descemet Stripping Only (DSO), znany również jako descemetorhexis without endothelial keratoplasty (DWEK). Ta mało inwazyjna procedura polega na selektywnym usunięciu uszkodzonej tkanki z centralnej warstwy śródbłonka, co pozwala zdrowym komórkom obwodowym migrować do centrum rogówki.262728

Najważniejsze zalety procedury DSO w porównaniu do standardowego przeszczepu rogówki:293031

  • Brak konieczności użycia tkanki dawcy – eliminuje ryzyko odrzucenia przeszczepu
  • Brak potrzeby długotrwałego stosowania steroidów – ogranicza potencjalne działania niepożądane
  • Procedura mniej inwazyjna niż tradycyjny przeszczep
  • Niższy koszt leczenia w porównaniu do keratoplastyki endotelialnej

Kwalifikacja pacjentów do zabiegu DSO jest kluczowa dla osiągnięcia optymalnych wyników. Pacjentów należy dokładnie poinformować o spodziewanym pogorszeniu widzenia w bezpośrednim okresie pooperacyjnym i przedłużonym czasie rekonwalescencji. Procedura nie jest zalecana u pacjentów, którzy mogą nie tolerować jakiegokolwiek pogorszenia widzenia w operowanym oku.3233

Zastosowanie inhibitorów Rho-kinazy

Badania wykazały, że pacjenci po zabiegu DSO leczeni miejscowym inhibitorem Rho-kinazy (ripasudil 0,4%) cztery razy dziennie przez 2 miesiące odzyskiwali wzrok szybciej niż grupa obserwacyjna, która przeszła DSO bez stosowania ripasudilu.34 Zarówno ripasudil, jak i netarsudil przyśpieszają oczyszczanie rogówki i zwiększają końcową liczbę komórek śródbłonka po zabiegu DSO.35

Aktualnie w fazie rozwoju znajdują się także bio-inżynieryjny czynnik wzrostu fibroblastów oraz małe cząsteczki, które mogą hamować efekt ekspansji powtórzeń stanowiących podłoże większości przypadków dystrofii Fuchsa.3637

Modyfikacja diety jako potencjalny czynnik ochronny

Istnieją wstępne doniesienia sugerujące, że dieta oparta wyłącznie na nieprzetworzonych produktach roślinnych może być korzystna w leczeniu dystrofii Fuchsa. Przewlekły stres oksydacyjny odgrywa kluczową rolę w progresji choroby, a dieta bogata w przeciwutleniacze mogłaby potencjalnie pomóc w jego redukcji.3839

Choć jest to obszar wymagający dalszych badań, pacjentom z dystrofią Fuchsa można zalecać spożywanie diety bogatej w warzywa liściaste i kolorowe, które są dobrym źródłem przeciwutleniaczy.40

Leczenie objawowe jako element profilaktyki wtórnej

We wczesnych stadiach dystrofii Fuchsa możliwe jest zastosowanie leczenia objawowego, które może opóźnić progresję choroby i konieczność przeszczepu rogówki:414243

  • Krople do oczu zawierające 5% chlorek sodu – poprawiają widzenie poprzez usuwanie nadmiaru wody z rogówki
  • Maści do oczu – łagodzą obrzęk rogówki
  • Regularne wizyty kontrolne – pozwalają na monitorowanie stanu choroby i dostosowywanie leczenia

Należy pamiętać, że długotrwały obrzęk rogówki zwiększa ryzyko rozwoju blizn rogówki, co zmniejsza wskaźnik powodzenia przeszczepu rogówki o częściowej grubości, jeśli będzie on konieczny w przyszłości.44

W przypadku zaawansowanej dystrofii Fuchsa, przeszczep rogówki pozostaje najskuteczniejszą opcją terapeutyczną, chociaż nowe metody, takie jak DSO, oferują obiecującą alternatywę dla wybranych pacjentów.4546

Kolejne rozdziały

Zapraszamy do dalszego czytania naszego leksykonu.

Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 13.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Fuchs’ Endothelial Dystrophy – EyeWiki
    https://eyewiki.org/Fuchs%E2%80%99_Endothelial_Dystrophy
    Fuchs dystrophy is an inherited corneal dystrophy affecting the endothelium. There is no primary prevention for this disease entity. […] The most prevalent genetic risk factor for Fuchs dystrophy is the CTG18.1 trinucleotide repeat expansion in TCF4. Affected individuals have at least a 50% chance of passing the gene on to their children. […] Environmental risk factors include smoking and body mass index. In the Reykjavik Eye Study, participants with a 20-pack year history of smoking experienced more than double the risk of cornea guttata. Higher weight and body mass index were associated with decreased risk of cornea guttata.
  • #2 Fuchs’ Corneal Dystrophy: Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/eye-health/fuchs-corneal-dystrophy
    There are no known ways to prevent Fuchs dystrophy. Doctors have more to learn about how the disease develops, the role of genes, and other risks like smoking. […] For now, the best ways to treat the disease are eye drops or ointments to remove fluids and ease cornea swelling in the early stages. If you have advanced Fuchs, the best treatment is a cornea transplant.
  • #3 Fuchs’ Corneal Dystrophy: Causes, Symptoms, Risk & Treatment
    https://www.allaboutvision.com/conditions/fuchs-corneal-dystrophy/
    There is no known prevention for Fuchs’ dystrophy. […] If you have been diagnosed with Fuchs’ corneal dystrophy, be sure to discuss this with your eye doctor if you are considering LASIK or other refractive surgery or if you have cataracts and need cataract surgery. These eye surgeries can worsen the condition, and corneal dystrophy often is considered a contraindication for elective refractive surgery.
  • #4 Fuchs’ Endothelial Dystrophy – EyeWiki
    https://eyewiki.org/Fuchs%E2%80%99_Endothelial_Dystrophy
    Fuchs dystrophy is an inherited corneal dystrophy affecting the endothelium. There is no primary prevention for this disease entity. […] The most prevalent genetic risk factor for Fuchs dystrophy is the CTG18.1 trinucleotide repeat expansion in TCF4. Affected individuals have at least a 50% chance of passing the gene on to their children. […] Environmental risk factors include smoking and body mass index. In the Reykjavik Eye Study, participants with a 20-pack year history of smoking experienced more than double the risk of cornea guttata. Higher weight and body mass index were associated with decreased risk of cornea guttata.
  • #5 Fuchs’ Dystrophy: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/23438-fuchs-dystrophy
    Theres currently no way to prevent Fuchs corneal dystrophy. But you can help yourself by quitting smoking if you do smoke. If you have diabetes, work with your healthcare provider to manage your blood sugar levels.
  • #6 Could your blurry vision be Fuchs’ dystrophy? | Nebraska Medicine Omaha, NE
    https://www.nebraskamed.com/health/conditions-and-services/eye-care/fuchs-dystrophy-symptoms-causes-and-treatment
    While there’s no way to prevent Fuchs’ dystrophy, you can manage certain risk factors by: […] Avoiding smoking. […] Eating a well-balanced diet with lots of leafy greens and colorful vegetables. […] Protecting your eyes from UV light by wearing sunglasses. […] Getting regular eye check-ups.
  • #7 Fuchs’ Endothelial Dystrophy – EyeWiki
    https://eyewiki.org/Fuchs%E2%80%99_Endothelial_Dystrophy
    Fuchs dystrophy is an inherited corneal dystrophy affecting the endothelium. There is no primary prevention for this disease entity. […] The most prevalent genetic risk factor for Fuchs dystrophy is the CTG18.1 trinucleotide repeat expansion in TCF4. Affected individuals have at least a 50% chance of passing the gene on to their children. […] Environmental risk factors include smoking and body mass index. In the Reykjavik Eye Study, participants with a 20-pack year history of smoking experienced more than double the risk of cornea guttata. Higher weight and body mass index were associated with decreased risk of cornea guttata.
  • #8 Fuchs’ Dystrophy: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/23438-fuchs-dystrophy
    Theres currently no way to prevent Fuchs corneal dystrophy. But you can help yourself by quitting smoking if you do smoke. If you have diabetes, work with your healthcare provider to manage your blood sugar levels.
  • #9 Could your blurry vision be Fuchs’ dystrophy? | Nebraska Medicine Omaha, NE
    https://www.nebraskamed.com/health/conditions-and-services/eye-care/fuchs-dystrophy-symptoms-causes-and-treatment
    While there’s no way to prevent Fuchs’ dystrophy, you can manage certain risk factors by: […] Avoiding smoking. […] Eating a well-balanced diet with lots of leafy greens and colorful vegetables. […] Protecting your eyes from UV light by wearing sunglasses. […] Getting regular eye check-ups.
  • #10 Could your blurry vision be Fuchs’ dystrophy? | Nebraska Medicine Omaha, NE
    https://www.nebraskamed.com/health/conditions-and-services/eye-care/fuchs-dystrophy-symptoms-causes-and-treatment
    While there’s no way to prevent Fuchs’ dystrophy, you can manage certain risk factors by: […] Avoiding smoking. […] Eating a well-balanced diet with lots of leafy greens and colorful vegetables. […] Protecting your eyes from UV light by wearing sunglasses. […] Getting regular eye check-ups.
  • #11
    https://ijdrp.org/index.php/ijdrp/article/view/127
    Fuchs endothelial corneal dystrophy (FECD) is a progressive disorder of the corneal endothelium characterized by endothelial cell functional abnormalities and loss of visual acuity. Chronic oxidative stress plays a key role in disease progression. […] This case suggests an exclusively whole-plant-food diet may be beneficial in the treatment of FECD.
  • #12 Fuchs’ Endothelial Dystrophy – EyeWiki
    https://eyewiki.org/Fuchs%E2%80%99_Endothelial_Dystrophy
    Fuchs dystrophy is an inherited corneal dystrophy affecting the endothelium. There is no primary prevention for this disease entity. […] The most prevalent genetic risk factor for Fuchs dystrophy is the CTG18.1 trinucleotide repeat expansion in TCF4. Affected individuals have at least a 50% chance of passing the gene on to their children. […] Environmental risk factors include smoking and body mass index. In the Reykjavik Eye Study, participants with a 20-pack year history of smoking experienced more than double the risk of cornea guttata. Higher weight and body mass index were associated with decreased risk of cornea guttata.
  • #13 Fuchs’ endothelial dystrophy | CERAFuchs’ endothelial dystrophy | CERA
    https://www.cera.org.au/conditions/fuchs-endothelial-dystrophy/
    Fuch’s endothelial dystrophy cannot be prevented. But having regular eye exams after the age of 50 can catch the disease before it starts causing pain and vision loss.
  • #14 Fuchs’ Dystrophy | Symptoms, Causes,Treatment | Wills Eye Hospital
    https://www.willseye.org/fuchs-dystrophy/
    Routine eye examinations are recommended to monitor the condition. […] Longstanding swelling increases the chances of developing corneal scarring which decreases the success rate of partial thickness corneal transplantation.
  • #15 Fuch’s Corneal Dystrophy: Causes, Symptoms, Treatment
    https://eyemantra.in/cornea/fuchs-corneal-dystrophy/
    Fuchs corneal dystrophy is a disorder of the cornea (front surface of the eye). […] The prevention of Fuchs Corneal disease is unknown. […] If detected in its earlier stages, vision problems can be prevented. […] These surgeries can worsen the condition. […] If you are noticing any of these symptoms visit your doctor before the disorder grows any further.
  • #16 Fuchs’ Dystrophy | Symptoms, Causes,Treatment | Wills Eye Hospital
    https://www.willseye.org/fuchs-dystrophy/
    Routine eye examinations are recommended to monitor the condition. […] Longstanding swelling increases the chances of developing corneal scarring which decreases the success rate of partial thickness corneal transplantation.
  • #17 Fuchs’ Corneal Dystrophy: Causes, Symptoms, Risk & Treatment
    https://www.allaboutvision.com/conditions/fuchs-corneal-dystrophy/
    There is no known prevention for Fuchs’ dystrophy. […] If you have been diagnosed with Fuchs’ corneal dystrophy, be sure to discuss this with your eye doctor if you are considering LASIK or other refractive surgery or if you have cataracts and need cataract surgery. These eye surgeries can worsen the condition, and corneal dystrophy often is considered a contraindication for elective refractive surgery.
  • #18 Fuchs dystrophy: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/007295.htm
    There is no known prevention. Avoiding cataract surgery or taking special precautions during cataract surgery may delay the need for a corneal transplant.
  • #19 Fuchs’ Corneal Dystrophy: Causes, Symptoms, Risk & Treatment
    https://www.allaboutvision.com/conditions/fuchs-corneal-dystrophy/
    There is no known prevention for Fuchs’ dystrophy. […] If you have been diagnosed with Fuchs’ corneal dystrophy, be sure to discuss this with your eye doctor if you are considering LASIK or other refractive surgery or if you have cataracts and need cataract surgery. These eye surgeries can worsen the condition, and corneal dystrophy often is considered a contraindication for elective refractive surgery.
  • #20 Fuchs dystrophy: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/007295.htm
    There is no known prevention. Avoiding cataract surgery or taking special precautions during cataract surgery may delay the need for a corneal transplant.
  • #21 Fuch’s Corneal Dystrophy: Causes, Symptoms, Treatment
    https://eyemantra.in/cornea/fuchs-corneal-dystrophy/
    Fuchs corneal dystrophy is a disorder of the cornea (front surface of the eye). […] The prevention of Fuchs Corneal disease is unknown. […] If detected in its earlier stages, vision problems can be prevented. […] These surgeries can worsen the condition. […] If you are noticing any of these symptoms visit your doctor before the disorder grows any further.
  • #22 Fuchs’ Corneal Dystrophy: Causes, Symptoms, Risk & Treatment
    https://www.allaboutvision.com/conditions/fuchs-corneal-dystrophy/
    There is no known prevention for Fuchs’ dystrophy. […] If you have been diagnosed with Fuchs’ corneal dystrophy, be sure to discuss this with your eye doctor if you are considering LASIK or other refractive surgery or if you have cataracts and need cataract surgery. These eye surgeries can worsen the condition, and corneal dystrophy often is considered a contraindication for elective refractive surgery.
  • #23 Fuchs Endothelial Dystrophy Treatment & Management: Medical Care, Surgical Care, Diet
    https://emedicine.medscape.com/article/1193591-treatment
    Patients should avoid rubbing and bumping the eye. […] Patients should use a protective shield at night and protective glasses during the day for at least 3 months, and ideally longer, after surgery. […] Patients should avoid splashing the eye with tap water when taking a bath. […] Avoid cleaning the eye with nonsterile products. […] Avoid applying cosmetics on the lid margin. […] Avoid smoke and dusty environment. […] Avoid putting any drops, other than prescribed drops, in the eye. […] Do not touch the nozzle of the eye drop bottle during use. Store the medicine bottle in a cool place, preferably inside a refrigerator. […] Patients should beware of warning signs; seek urgent consultation if any of the following warning signs occur: Feeling of heaviness and pain, Redness of the eye, especially around the cornea, Diminution of eyesight, Light sensitivity.
  • #24 Fuchs Endothelial Dystrophy Treatment & Management: Medical Care, Surgical Care, Diet
    https://emedicine.medscape.com/article/1193591-treatment
    Patients should avoid rubbing and bumping the eye. […] Patients should use a protective shield at night and protective glasses during the day for at least 3 months, and ideally longer, after surgery. […] Patients should avoid splashing the eye with tap water when taking a bath. […] Avoid cleaning the eye with nonsterile products. […] Avoid applying cosmetics on the lid margin. […] Avoid smoke and dusty environment. […] Avoid putting any drops, other than prescribed drops, in the eye. […] Do not touch the nozzle of the eye drop bottle during use. Store the medicine bottle in a cool place, preferably inside a refrigerator. […] Patients should beware of warning signs; seek urgent consultation if any of the following warning signs occur: Feeling of heaviness and pain, Redness of the eye, especially around the cornea, Diminution of eyesight, Light sensitivity.
  • #25 Fuch’s Corneal Dystrophy: Causes, Symptoms, Treatment
    https://eyemantra.in/cornea/fuchs-corneal-dystrophy/
    Fuchs corneal dystrophy is a disorder of the cornea (front surface of the eye). […] The prevention of Fuchs Corneal disease is unknown. […] If detected in its earlier stages, vision problems can be prevented. […] These surgeries can worsen the condition. […] If you are noticing any of these symptoms visit your doctor before the disorder grows any further.
  • #26 An Alternative Treatment Option for Fuchs Corneal Dystrophy | CollaborativeEYE
    https://collaborativeeye.com/articles/2020-nov-dec/an-alternative-treatment-option-for-fuchs-corneal-dystrophy/
    Fuchs endothelial corneal dystrophy is the most common indication for keratoplasty in the United States. Endothelial keratoplasty (EK) is the current standard of care when the disease causes problematic visual symptoms. Descemet stripping only (DSO) is a technique in which dysfunctional central corneal endothelium and Descemet membrane are removed, allowing healthier peripheral cells to migrate into the area. DSO uses no donor tissue, so there is no rejection risk and no need for long-term steroid use. […] Although both of these EK procedures have a high success rate, the risks associated with donor transplantation are still present. […] DSO has demonstrated encouraging short-term outcomes for appropriate candidates, but long-term results are still being investigated.
  • #27 CRST Global | Evolving Surgical Options for Fuchs Dystrophy
    https://crstodayeurope.com/articles/2019-june/evolving-surgical-options-for-fuchs-dystrophy/
    Evolving Surgical Options for Fuchs Dystrophy […] In recent years, an exciting innovation in the management of Fuchs dystrophy has been the advent of Descemet stripping only (DSO), also known as descemetorhexis without endothelial keratoplasty (DWEK). […] The most notable difference is eliminating the requirement for a donor cornea. […] With DSO, some of these cases can be managed without performing a transplant at all. […] It is important to thoroughly counsel patients to expect poor vision in the immediate postoperative period and a prolonged recovery. […] This procedure should be avoided in patients who may be intolerant of any deterioration of vision in the surgical eye. […] In general, patients receive the same postoperative drops after DSO as they would after cataract surgery.
  • #28 Cornea: Pioneering Fuchs Dystrophy Treatment Combines Surgery & Therapeutic to Regenerate Tissue | NYU Langone News
    https://nyulangone.org/news/cornea-pioneering-fuchs-dystrophy-treatment-combines-surgery-therapeutic-regenerate-tissue
    For patients with Fuchs dystrophy a common corneal condition that progresses to sight loss and is the leading indication for corneal transplant the development of a novel treatment approach holds new promise for enhanced outcomes. […] The selective removal of damaged tissue within the central endothelial layer has been shown over time to effectively restore function while eliminating the risks associated with corneal transplant. […] Equipping the body with its own means to heal is always preferable to foreign transplant, and we now understand that endothelial cells do in fact have that capability once damaged tissue is resected, notes Dr. Colby. This is a revolution in the surgical treatment of Fuchs disease.
  • #29 CRST Global | Evolving Surgical Options for Fuchs Dystrophy
    https://crstodayeurope.com/articles/2019-june/evolving-surgical-options-for-fuchs-dystrophy/
    Evolving Surgical Options for Fuchs Dystrophy […] In recent years, an exciting innovation in the management of Fuchs dystrophy has been the advent of Descemet stripping only (DSO), also known as descemetorhexis without endothelial keratoplasty (DWEK). […] The most notable difference is eliminating the requirement for a donor cornea. […] With DSO, some of these cases can be managed without performing a transplant at all. […] It is important to thoroughly counsel patients to expect poor vision in the immediate postoperative period and a prolonged recovery. […] This procedure should be avoided in patients who may be intolerant of any deterioration of vision in the surgical eye. […] In general, patients receive the same postoperative drops after DSO as they would after cataract surgery.
  • #30 An Alternative Treatment Option for Fuchs Corneal Dystrophy | CollaborativeEYE
    https://collaborativeeye.com/articles/2020-nov-dec/an-alternative-treatment-option-for-fuchs-corneal-dystrophy/
    Fuchs endothelial corneal dystrophy is the most common indication for keratoplasty in the United States. Endothelial keratoplasty (EK) is the current standard of care when the disease causes problematic visual symptoms. Descemet stripping only (DSO) is a technique in which dysfunctional central corneal endothelium and Descemet membrane are removed, allowing healthier peripheral cells to migrate into the area. DSO uses no donor tissue, so there is no rejection risk and no need for long-term steroid use. […] Although both of these EK procedures have a high success rate, the risks associated with donor transplantation are still present. […] DSO has demonstrated encouraging short-term outcomes for appropriate candidates, but long-term results are still being investigated.
  • #31 Simple procedure could improve treatment for common eye disease – UChicago Medicine
    https://www.uchicagomedicine.org/forefront/news/simple-procedure-could-improve-treatment-for-common-eye-disease
    A new, minimally invasive procedure appears to be effective for many patients with Fuchs endothelial dystrophy (FED), a common eye disease, without the potential side effects and cost of the current standard of care, a cornea transplant. […] „Although Descemet stripping is a relatively simple procedure, its potential is revolutionary,” Colby said. […] The next step is to try to understand why some patients, about one out of four, don’t respond to removal of the dysfunctional cells. Fuchs dystrophy is a polygenic disease, but in the last few years researchers have found connections between the extent of a repeating nonsensical genetic abnormality seen in other neurological diseases and the severity of FED. Colby hopes to find genetic clues that predict which patients are most likely to respond to this approach.
  • #32 CRST Global | Evolving Surgical Options for Fuchs Dystrophy
    https://crstodayeurope.com/articles/2019-june/evolving-surgical-options-for-fuchs-dystrophy/
    Evolving Surgical Options for Fuchs Dystrophy […] In recent years, an exciting innovation in the management of Fuchs dystrophy has been the advent of Descemet stripping only (DSO), also known as descemetorhexis without endothelial keratoplasty (DWEK). […] The most notable difference is eliminating the requirement for a donor cornea. […] With DSO, some of these cases can be managed without performing a transplant at all. […] It is important to thoroughly counsel patients to expect poor vision in the immediate postoperative period and a prolonged recovery. […] This procedure should be avoided in patients who may be intolerant of any deterioration of vision in the surgical eye. […] In general, patients receive the same postoperative drops after DSO as they would after cataract surgery.
  • #33 ESCRS – DSO Shows Promise in Treating Fuchs’ Dystrophy
    https://escrs.org/channels/eurotimes-articles/dso-shows-promise-in-treating-fuchs-dystrophy
    We need to bear in mind that immediately [after] surgery, there will be worse vision after DSO. We remove the endothelium and Descemet membrane, so there will be corneal oedema. The duration of the effect is also not known. The remaining endothelial cells that repopulated the central cornea still have the disease. However, my index patient is now 10 years out from treatment and is still doing well. […] Dr Colby offered three tips to maximise outcomes from DSO treatments: patient selection, surgical technique, and ROCK inhibitor supplementation. […] Finally, she advised using a ROCK inhibitor after DSO surgery. Both ripasudil and netarsudil have been shown to speed corneal clearance and increase final endothelial cell count after DSO in investigator-initiated series. […] We know the corneal guttae themselves are visually significant. DSO offers a nice option [for combination] with some new therapies that may improve endothelial cell function or reduce the continued dysfunction of the cells, she said. In development right now are a bio-engineered fibroblastic growth factor and small molecules which can inhibit the downstream effect of repeat expansion underlying the bulk of FECD.
  • #34 CRST Global | Evolving Surgical Options for Fuchs Dystrophy
    https://crstodayeurope.com/articles/2019-june/evolving-surgical-options-for-fuchs-dystrophy/
    A recent study by Macsai and Shiloach showed that DSO patients treated with a topical Rho kinase inhibitor (ripasudil 0.4%, Glanatec, Kowa) four times daily for 2 months recovered vision more quickly than an observation group that underwent DSO without topical ripasudil. […] It is important to counsel patients carefully on a prolonged postoperative recovery period and the possibility of requiring endothelial keratoplasty as a rescue procedure if corneal edema does not clear.
  • #35 ESCRS – DSO Shows Promise in Treating Fuchs’ Dystrophy
    https://escrs.org/channels/eurotimes-articles/dso-shows-promise-in-treating-fuchs-dystrophy
    We need to bear in mind that immediately [after] surgery, there will be worse vision after DSO. We remove the endothelium and Descemet membrane, so there will be corneal oedema. The duration of the effect is also not known. The remaining endothelial cells that repopulated the central cornea still have the disease. However, my index patient is now 10 years out from treatment and is still doing well. […] Dr Colby offered three tips to maximise outcomes from DSO treatments: patient selection, surgical technique, and ROCK inhibitor supplementation. […] Finally, she advised using a ROCK inhibitor after DSO surgery. Both ripasudil and netarsudil have been shown to speed corneal clearance and increase final endothelial cell count after DSO in investigator-initiated series. […] We know the corneal guttae themselves are visually significant. DSO offers a nice option [for combination] with some new therapies that may improve endothelial cell function or reduce the continued dysfunction of the cells, she said. In development right now are a bio-engineered fibroblastic growth factor and small molecules which can inhibit the downstream effect of repeat expansion underlying the bulk of FECD.
  • #36 ESCRS – DSO Shows Promise in Treating Fuchs’ Dystrophy
    https://escrs.org/channels/eurotimes-articles/dso-shows-promise-in-treating-fuchs-dystrophy
    We need to bear in mind that immediately [after] surgery, there will be worse vision after DSO. We remove the endothelium and Descemet membrane, so there will be corneal oedema. The duration of the effect is also not known. The remaining endothelial cells that repopulated the central cornea still have the disease. However, my index patient is now 10 years out from treatment and is still doing well. […] Dr Colby offered three tips to maximise outcomes from DSO treatments: patient selection, surgical technique, and ROCK inhibitor supplementation. […] Finally, she advised using a ROCK inhibitor after DSO surgery. Both ripasudil and netarsudil have been shown to speed corneal clearance and increase final endothelial cell count after DSO in investigator-initiated series. […] We know the corneal guttae themselves are visually significant. DSO offers a nice option [for combination] with some new therapies that may improve endothelial cell function or reduce the continued dysfunction of the cells, she said. In development right now are a bio-engineered fibroblastic growth factor and small molecules which can inhibit the downstream effect of repeat expansion underlying the bulk of FECD.
  • #37 Simple procedure could improve treatment for common eye disease – UChicago Medicine
    https://www.uchicagomedicine.org/forefront/news/simple-procedure-could-improve-treatment-for-common-eye-disease
    A new, minimally invasive procedure appears to be effective for many patients with Fuchs endothelial dystrophy (FED), a common eye disease, without the potential side effects and cost of the current standard of care, a cornea transplant. […] „Although Descemet stripping is a relatively simple procedure, its potential is revolutionary,” Colby said. […] The next step is to try to understand why some patients, about one out of four, don’t respond to removal of the dysfunctional cells. Fuchs dystrophy is a polygenic disease, but in the last few years researchers have found connections between the extent of a repeating nonsensical genetic abnormality seen in other neurological diseases and the severity of FED. Colby hopes to find genetic clues that predict which patients are most likely to respond to this approach.
  • #38
    https://ijdrp.org/index.php/ijdrp/article/view/127
    Fuchs endothelial corneal dystrophy (FECD) is a progressive disorder of the corneal endothelium characterized by endothelial cell functional abnormalities and loss of visual acuity. Chronic oxidative stress plays a key role in disease progression. […] This case suggests an exclusively whole-plant-food diet may be beneficial in the treatment of FECD.
  • #39 Could your blurry vision be Fuchs’ dystrophy? | Nebraska Medicine Omaha, NE
    https://www.nebraskamed.com/health/conditions-and-services/eye-care/fuchs-dystrophy-symptoms-causes-and-treatment
    While there’s no way to prevent Fuchs’ dystrophy, you can manage certain risk factors by: […] Avoiding smoking. […] Eating a well-balanced diet with lots of leafy greens and colorful vegetables. […] Protecting your eyes from UV light by wearing sunglasses. […] Getting regular eye check-ups.
  • #40 Could your blurry vision be Fuchs’ dystrophy? | Nebraska Medicine Omaha, NE
    https://www.nebraskamed.com/health/conditions-and-services/eye-care/fuchs-dystrophy-symptoms-causes-and-treatment
    While there’s no way to prevent Fuchs’ dystrophy, you can manage certain risk factors by: […] Avoiding smoking. […] Eating a well-balanced diet with lots of leafy greens and colorful vegetables. […] Protecting your eyes from UV light by wearing sunglasses. […] Getting regular eye check-ups.
  • #41 What You Should Know About Fuchs’ Endothelial Dystrophy
    https://www.2920eyephysicians.com/2015/01/eye-diseases-fuchs-endothelial-dystrophy/
    Although there is no known prevention for Fuchs endothelial dystrophy, this disease can be treated with eye drops when detected in the early stages. […] Eye drops that contain 5% sodium chloride are used and can improve vision by removing excess water from the cornea.
  • #42 Fuchs’ Corneal Dystrophy: Symptoms, Causes, Diagnosis, Treatment
    https://www.webmd.com/eye-health/fuchs-corneal-dystrophy
    There are no known ways to prevent Fuchs dystrophy. Doctors have more to learn about how the disease develops, the role of genes, and other risks like smoking. […] For now, the best ways to treat the disease are eye drops or ointments to remove fluids and ease cornea swelling in the early stages. If you have advanced Fuchs, the best treatment is a cornea transplant.
  • #43 Corneal Disease Treatment in Dayton | CVP Physicians Dayton
    https://www.cvpdaytoneyedoctors.com/cornea/fuchs-dystrophy/
    Fuchs dystrophy causes swelling of the cornea, often leading to blurred vision, excessive glare, eye pain, and other symptoms. This is a progressive condition for which there is no cure, but your ophthalmologist can help alleviate symptoms and slow the swelling that impacts the cornea. […] Once advanced, Fuchs dystrophy must be treated with corneal transplant surgery.
  • #44 Fuchs’ Dystrophy | Symptoms, Causes,Treatment | Wills Eye Hospital
    https://www.willseye.org/fuchs-dystrophy/
    Routine eye examinations are recommended to monitor the condition. […] Longstanding swelling increases the chances of developing corneal scarring which decreases the success rate of partial thickness corneal transplantation.
  • #45 Corneal Disease Treatment in Dayton | CVP Physicians Dayton
    https://www.cvpdaytoneyedoctors.com/cornea/fuchs-dystrophy/
    Fuchs dystrophy causes swelling of the cornea, often leading to blurred vision, excessive glare, eye pain, and other symptoms. This is a progressive condition for which there is no cure, but your ophthalmologist can help alleviate symptoms and slow the swelling that impacts the cornea. […] Once advanced, Fuchs dystrophy must be treated with corneal transplant surgery.
  • #46 Cornea: Pioneering Fuchs Dystrophy Treatment Combines Surgery & Therapeutic to Regenerate Tissue | NYU Langone News
    https://nyulangone.org/news/cornea-pioneering-fuchs-dystrophy-treatment-combines-surgery-therapeutic-regenerate-tissue
    For patients with Fuchs dystrophy a common corneal condition that progresses to sight loss and is the leading indication for corneal transplant the development of a novel treatment approach holds new promise for enhanced outcomes. […] The selective removal of damaged tissue within the central endothelial layer has been shown over time to effectively restore function while eliminating the risks associated with corneal transplant. […] Equipping the body with its own means to heal is always preferable to foreign transplant, and we now understand that endothelial cells do in fact have that capability once damaged tissue is resected, notes Dr. Colby. This is a revolution in the surgical treatment of Fuchs disease.