Materiały źródłowe

• #1 Paget’s disease of bone – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/symptoms-causes/syc-20350811

  Most people who have Paget’s disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain. […] Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that’s less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures. […] The disease might affect only one or two areas of your body or might be widespread. Your signs and symptoms, if any, will depend on the affected part of your body. […] Paget’s disease of bone in the pelvis can cause hip pain. […] An overgrowth of bone in the skull can cause hearing loss or headaches. […] If your spine is affected, nerve roots can become compressed. This can cause pain, tingling and numbness in an arm or leg. […] As the bones weaken, they may bend causing you to become bowlegged. Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip.

• #1

  https://www.nhs.uk/conditions/pagets-disease-bone/symptoms/

  Symptoms of Paget’s disease of bone include bone or joint pain and problems caused by a nerve being squashed or damaged. […] Paget’s disease may cause pain in the bone itself and in the joints near the affected bone. […] The bone pain is usually dull or aching, deep within the affected part of the body, constant, and worse at night. […] Abnormal bone growth can result in bone squashing (compressing) or damaging a nearby nerve. […] Possible signs of this can include pain travelling from the spine down into your legs (sciatica), numbness or tingling in the affected limbs (peripheral neuropathy), partial loss of movement in your limbs, balance problems, and loss of bowel control (bowel incontinence) or loss of bladder control (urinary incontinence). […] Paget’s disease of bone can also cause a range of other problems, including fragile bones that are more likely to break, osteoarthritis damage to the joints, causing painful and stiff joints, deformities in affected bones, such as curved legs (bow legs) or a curved spine (scoliosis), hearing loss, headaches, vertigo (a spinning sensation) and tinnitus (hearing noises in your ears) these may occur if the skull is affected, and heart problems. […] See a GP if you have persistent bone or joint pain, deformities in any of your bones, or symptoms of a nerve problem, such as numbness, tingling or balance problems.

• #1 Paget’s disease of bone | Causes, symptoms, treatments

  https://versusarthritis.org/about-arthritis/conditions/pagets-disease-of-bone/

  Often there are no symptoms at all. Pagets disease is often diagnosed by chance when an x-ray or blood test is taken for some other reason. […] For those who do have symptoms, pain is the most common problem and is usually felt in the bone itself or in the joints near the affected bones. Pain linked to Pagets disease may be caused by: increased blood flow in the affected areas, which can also result in those areas feeling unusually warm to the touch; nerve fibres surrounding the bone being stretched as a result of bones growing larger or bending; damage in the joints near the affected bones; enlarged bone pressing on the nerves. […] You should see your GP if you have any of the following symptoms: persistent bone or joint pain; visible changes in the shape of your bones; numbness, tingling or loss of movement which might be signs of nerve problems.

• #1 Symptoms and complications | Paget’s Association

  https://paget.org.uk/pagets-disease/what-is-pagets-and-how-is-it-managed/symptoms-and-complications/

  The symptoms of Pagets disease vary widely. […] Many people who have Pagets disease do not have symptoms and never develop complications. In many cases, individuals are unaware that they have the condition. […] Of those who present with symptoms, pain is the most common. Pain may arise from the affected bone itself, or from the altered biomechanics as the result of limb deformity; for example, a bowed leg alters the way you walk and puts stress on the joints and soft tissues. […] The blood flow to active areas of Pagets disease increases and this can lead to a feeling of warmth over the affected bone. […] The affected bone may become enlarged and misshapen. […] The potential for complications will depend on which bones are affected by Pagets disease. […] Complications may require medical or surgical intervention.

• #1 Paget’s disease of bone – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/symptoms-causes/syc-20350811

  In most cases, Paget’s disease of bone progresses slowly. The disease can be managed effectively in nearly all people. Possible complications include: […] Affected bones break more easily, and extra blood vessels in these deformed bones cause them to bleed more during repair surgeries. Leg bones can bow, which can affect your ability to walk. […] Misshapen bones can increase the amount of stress on nearby joints, which can cause osteoarthritis. […] When Paget’s disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss. […] In severe cases, your heart may have to work harder to pump blood to the affected areas of your body. Sometimes, this increased workload can lead to heart failure. […] Bone cancer occurs in up to 1% of people with Paget’s disease of bone.

• #1 Paget Disease: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/334607-overview

  Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. Approximately 70-90% of persons with Paget disease are asymptomatic; however, a minority of affected individuals experience various symptoms, including the following: Bone pain (the most common symptom), Secondary osteoarthritis (when Paget disease occurs around a joint), Bony deformity (most commonly bowing of an extremity), Excessive warmth (due to hypervascularity), Neurologic complications (caused by the compression of neural tissues). Paget disease may involve a single bone but is more frequently multifocal. It has a predilection for the axial skeleton (ie, spine, pelvis, femur, sacrum, and skull, in descending order of frequency), but any bone may be affected. After onset, Paget disease does not spread from bone to bone, but it may become progressively worse at preexisting sites. Sarcomatous degeneration of pagetic bone is an uncommon but often deadly complication. Pagetic sarcoma is malignant, and the course usually is rapid and fatal. The general outlook for patients with Paget disease is good, especially if treatment is administered before major changes have occurred in the bones. Treatment does not cure Paget disease, but it can control it. Patients with severe polyostotic Paget disease have a less favorable prognosis than those with monostotic disease. Patients with polyostotic disease are at higher risk for complications. Morbidity from Paget disease can be extensive. The excessive remodeling of bone that occurs may result in pain, fractures, and bone deformities. Additional complications include osteoarthritis, deafness, hydrocephalus, neurologic disease, and osteosarcoma. Complications associated with fractures, such as articular and neurologic problems, may increase mortality in patients with Paget disease. The prognosis is extremely unfavorable if any type of sarcomatous degeneration develops, especially if it is multicentric. The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur.

• #1 Paget disease (bone) | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/paget-disease-bone?lang=us

  Paget disease of the bone is a common, chronic metabolic bone disorder characterized by excessive abnormal bone remodeling. The classically described radiological appearances are expanded bone with a coarsened trabecular pattern. The pelvis, spine, skull, and proximal long bones are most frequently affected. […] The majority (approximately three-quarters) of patients are asymptomatic at the time of diagnosis, the diagnosis being an incidental finding on imaging. Presenting symptoms include: localized pain and tenderness (most common symptom), increased focal temperature due to bony hypervascularity (not fever), increased bone size: historically, changing hat size was a giveaway, bowing deformities, kyphosis, decreased range of motion, signs and symptoms relating to complications. […] If untreated, active lesions are estimated to progress at a rate of 12 cm per year. […] The prognosis and evolution of pagetic lesions was established by studies from the pre-bisphosphonate era. If left untreated, active lytic lesions were estimated to progress at a rate of 12 cm per year. Associated complications became more likely as the disease progressed.

• #1 Paget’s Disease of Bone – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/pagets-disease-of-bone

  Symptoms can also arise from the effect of the disease on calcium levels in the blood stream. When Paget’s disease is active in several bones, overactive osteoclasts may release enough calcium from the bone as they break it down to cause an elevated calcium level in the blood. This rare complication can lead to a number of symptoms, including: Fatigue, Weakness, Loss of appetite, Abdominal pain, Constipation. […] Very rarely, Pagets disease can progress to a type of bone cancer called Pagets sarcoma. When this occurs, symptoms may include severe and unrelenting pain in the area affected by Pagets disease. Paget’s sarcoma occurs in only about 1 percent of patients with Paget’s disease. These patients are usually over the age of 70. This type of malignant bone tumor is very aggressive and has a poor prognosis. None of the medical treatments for Paget’s disease are known to lower the risk for the development of Paget’s sarcoma.

• #1 Paget’s Disease – Skull and Teeth

  https://www.icliniq.com/articles/orthopedic-health/pagets-disease

  The progression of Paget’s disease of bone can vary widely from person to person. Some people may have the condition for many years without experiencing any symptoms or complications, while others may experience rapid progression and severe symptoms. Factors that can affect the progression of Paget’s disease include the size and location of the affected bone, the person’s age, and overall health. […] The progression of Paget’s disease can vary greatly among individuals. Some people may have very mild symptoms with little bone damage, while others may have more severe and significant bone damage.

• #1 Paget’s Disease of Bone: Symptoms, Diagnosis, Treatment

  https://www.webmd.com/osteoporosis/pagets-disease-bone

  The symptoms appear slowly over time, and the majority of people have no symptoms and don’t know they have Paget’s. […] Bone pain is common. Some people also get arthritis in joints near the affected bones. They are more at risk of breaking the affected (and weakened) bone. […] If your skull is involved, you could have headaches, vision problems, hearing loss, pain in your face, and numbness or tingling. […] Sometimes you can see the bone changes. Your legs and thighs may look larger than usual and may seem bent or bowed. Your forehead can look bigger, too. If Paget’s gets worse, you may waddle when you walk. […] In rare cases, serious pain means the Paget’s has led to bone cancer. Other rare problems include congestive heart failure (where your heart doesn’t pump enough blood to meet your body’s needs) and pressure on the tissue of your brain.

• #1 Paget’s Disease of Bone Causes, Symptoms, Treatment, Medications, Prevention

  https://www.medicinenet.com/pagets_disease/article.htm

  The outlook for living with Paget’s disease is generally good, particularly if treatment is given before major changes in the affected bones have occurred. […] In general, symptoms progress slowly. […] Paget’s disease is not a bone cancer, and the disease does not spread to normal bones. […] Overall health of the patient is usually not affected by Paget’s disease. […] Treatment can control Paget’s disease and lessen symptoms, but treatment does not cure Paget’s disease.

• #1 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone/syndicate

  Pagets disease of bone is a chronic (long-lasting) disorder that causes bones to grow larger and become weaker than normal. Many people with Pagets disease do not experience symptoms specific to the disease. However, the bone changes can cause: Bone pain. Misshapen bones. Broken bones (fractures). Inflammation and arthritis in the joints close to the affected bones. […] You may not know you have Pagets disease because many people with the disease do not have symptoms. However, fractures or misshapen bones can develop and cause pain. Sometimes, this bone pain, which is the most common symptom of the disease, is mistaken for arthritis or other disorders. Generally, symptoms develop slowly, and the disease does not spread to normal bones. […] In addition, some people with advanced disease may have misshapen bones and other bone changes, which may include: Increase in head size. Bow shape of a limb. Curvature of the spine.

• #1 Paget’s disease of bone – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/diagnosis-treatment/drc-20350816

  During the physical exam, your doctor will examine areas of your body that are causing you pain. […] The first indication of Paget’s disease of bone is often abnormalities found on X-rays done for other reasons. X-ray images of your bones can show areas of bone breakdown, enlargement of the bone and deformities that are characteristic of the disease, such as bowing of your long bones. […] People who have Paget’s disease of bone usually have elevated levels of alkaline phosphatase in their blood, which can be revealed by a blood test. […] If the disease is active indicated by an elevated alkaline phosphatase level and is affecting high-risk sites in your body, such as your skull or spine, your doctor might recommend treatment to prevent complications, even if you don’t have symptoms. […] Rarely, bisphosphonate therapy has been linked to severe muscle, joint or bone pain, which might not resolve when the medication is discontinued.

• #1 Paget’s disease | Endocrine Conditions

  https://www.yourhormones.info/endocrine-conditions/pagets-disease/

  Paget’s disease is a common, chronic bone disorder which may have no symptoms or it may cause pain, deformity and bone fracture. […] The majority of patients have no symptoms and many individuals are unaware that they have the disease until it is discovered when the patient is being examined for other reasons. […] Pain arising from the affected bone is the most common symptom. Since Pagets disease can cause a greater risk of fractures in affected bones, patients may initially go to the doctor with a fracture. […] Different signs or symptoms can sometimes be seen depending on which bones are affect. For example, if the Pagets disease affects bones in the skull, this may also cause deafness. If Pagets disease is in the spine, this may lead to pressure on nerves causing pain and leg weakness. If the ends of bones near the joint are affected, it can cause osteoarthritis in the joint. If the affected bones supports body weight, it may deform into a bowed or bent shape. […] When treating Pagets disease, a multidisciplinary approach should be adopted. Although appropriate treatment will minimise complications, deformity and joint damage can restrict mobility in some people causing the need to use walking aids and adaptations at home.

• #1 Paget’s Disease of the Bone Symptoms & Causes | Baptist Health

  https://cd.baptisthealth.com/care-services/conditions-treatments/pagets-disease-of-the-bone

  If Paget’s disease affects your skull, you can experience hearing issues or hearing loss. […] Damaged cartilage and excess pressure on your joints can cause arthritis. […] Paget’s disease usually progresses slowly. Therefore, most individuals living with Paget’s disease find that the condition is manageable with few complications. However, complications are possible. […] Paget’s disease prognosis is generally optimistic. The outcome of treatment depends on many factors, including your age, health, and the severity of the condition. A healthy diet and exercise can further help strengthen your bones and improve your quality of life.

• #2 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone

  Pagets disease of bone is a chronic (long-lasting) disorder that causes bones to grow larger and become weaker than normal. […] Many people with Pagets disease do not experience symptoms specific to the disease. However, the bone changes can cause: Bone pain. Misshapen bones. Broken bones (fractures). Inflammation and arthritis in the joints close to the affected bones. […] You may not know you have Pagets disease because many people with the disease do not have symptoms. However, fractures or misshapen bones can develop and cause pain. Sometimes, this bone pain, which is the most common symptom of the disease, is mistaken for arthritis or other disorders. […] Pagets disease can affect any bone, but usually occurs in: Spine. Pelvis. Femur and Tibia (leg bones). Skull. […] In addition, some people with advanced disease may have misshapen bones and other bone changes, which may include: Increase in head size. Bow shape of a limb. Curvature of the spine.

• #2 Paget’s disease of bone | Causes, symptoms, treatments

  https://versusarthritis.org/about-arthritis/conditions/pagets-disease-of-bone/

  Often there are no symptoms at all. Pagets disease is often diagnosed by chance when an x-ray or blood test is taken for some other reason. […] For those who do have symptoms, pain is the most common problem and is usually felt in the bone itself or in the joints near the affected bones. Pain linked to Pagets disease may be caused by: increased blood flow in the affected areas, which can also result in those areas feeling unusually warm to the touch; nerve fibres surrounding the bone being stretched as a result of bones growing larger or bending; damage in the joints near the affected bones; enlarged bone pressing on the nerves. […] You should see your GP if you have any of the following symptoms: persistent bone or joint pain; visible changes in the shape of your bones; numbness, tingling or loss of movement which might be signs of nerve problems.

• #2 Paget’s Disease of Bone – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/pagets-disease-of-bone

  Paget’s disease of bone is a chronic disease of the skeleton. In healthy bone, a process called remodeling removes old pieces of bone and replaces them with new, fresh bone. Pagets disease causes this process to shift out of balance, resulting in new bone that is abnormally shaped, weak, and brittle. Pagets disease most often affects older people, occurring in approximately 2 to 3% of the population over the age of 55. […] Many patients with Pagets disease have no symptoms at all and are unaware they have the disease until X-rays are taken for some other reason. When bone pain and other symptoms are present, they can be related to the disease itself or to complications that arise from the disease such as arthritis, bone deformity, and fractures. […] In patients who do have symptoms, bone pain is the most common complaint. This pain can be related to active Paget’s disease or to its complications, which include: Fractures due to brittle bone. Deformity of bone, including bowing of the affected bone. Advanced arthritis in joints near the affected bone. Compression on neighboring nerves from enlarged bones, leading to a loss of sensation or movement.

• #2 Paget’s disease of bone – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/symptoms-causes/syc-20350811

  Most people who have Paget’s disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain. […] Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that’s less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures. […] The disease might affect only one or two areas of your body or might be widespread. Your signs and symptoms, if any, will depend on the affected part of your body. […] Paget’s disease of bone in the pelvis can cause hip pain. […] An overgrowth of bone in the skull can cause hearing loss or headaches. […] If your spine is affected, nerve roots can become compressed. This can cause pain, tingling and numbness in an arm or leg. […] As the bones weaken, they may bend causing you to become bowlegged. Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip.

• #2 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone

  Other symptoms can develop, depending on the bone affected and can include: Headaches and hearing loss when Pagets disease affects the skull. Tingling and numbness in arms and legs when enlarged vertebrae put pressure on the nerves in the spine. Hip pain, which may occur when Pagets disease affects the pelvis or thighbone. […] Depending on the bone or bones affected by Pagets disease, other medical problems can develop, such as: Damage to joint cartilage can lead to arthritis. Changes in the bones of the skull and ear can lead to hearing loss. For some people who have heart disease already and severe Pagets disease, the extra workload of pumping blood throughout the body can lead to heart failure. Enlarged bones in the skull and spine can lead to pressure on the brain, spinal cord, or nerves and reduced blood flow to the brain and spinal cord. When Pagets disease affects the facial bones, the teeth may loosen. This may make chewing more difficult. Rarely, people with Pagets disease can develop bone cancer.

• #2 Paget’s disease of bone | Causes, symptoms, treatments

  https://versusarthritis.org/about-arthritis/conditions/pagets-disease-of-bone/

  Osteoarthritis: Abnormal bone growth can put extra strain on the joints and damage the cartilage that covers the ends of the bones. This can lead to osteoarthritis in the joint. Symptoms of osteoarthritis include pain (especially when the joint is moved), stiffness, and sometimes swelling. […] Tumours: Very rarely a cancerous tumour can develop in a bone affected by Pagets disease. Its estimated that this happens in less than 1 in 500 cases. The first signs of this are increased pain and swelling around the tumour.

• #2 Paget’s Disease of Bone Causes, Symptoms, Treatment, Medications, Prevention

  https://www.medicinenet.com/pagets_disease/article.htm

  The outlook for living with Paget’s disease is generally good, particularly if treatment is given before major changes in the affected bones have occurred. […] In general, symptoms progress slowly. […] Paget’s disease is not a bone cancer, and the disease does not spread to normal bones. […] Overall health of the patient is usually not affected by Paget’s disease. […] Treatment can control Paget’s disease and lessen symptoms, but treatment does not cure Paget’s disease.

• #2 Paget’s disease of bone – Wikipedia

  https://en.wikipedia.org/wiki/Paget%27s_disease_of_bone

  Paget’s disease of bone is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. These structural changes cause the bone to weaken, which may result in deformity, pain, fracture or arthritis of associated joints. […] Mild or early cases of Paget’s are asymptomatic, and so most people are diagnosed with Paget’s disease incidentally during medical evaluation for another problem. Approximately 35% of patients with Paget’s have symptoms related to the disease when they are first diagnosed. Overall, the most common symptom is bone pain. When symptoms do occur, they may be confused with those of arthritis or other disorders, and so diagnosis may be delayed. Paget’s may first be noticed as an increasing deformity of a person’s bones.

• #2 Treatment of Paget’s Disease of Bone

  https://www.uspharmacist.com/article/treatment-of-pagets-disease-of-bone

  Pagets disease of bone, also known as osteitis deformans, is a localized disorder of the skeletal system that is characterized by increased bone turnover. The clinical presentation of Pagets disease ranges from no symptoms to bone pain, painful skeletal deformities, or fractures. Many patients have active disease for many years before presentation, since the disorder progresses at a rate of 1 cm per year in long bones. Over time, untreated Pagets disease has the potential to become debilitating. […] Bone pain is characteristically present at rest, at night, and with use of the affected bone. Deformities that occur in the skull, facial bones, and extremities are more easily identifiable. Incomplete fissure fractures and complete fractures, which are typically transverse breaks, can be a major complication of Pagets disease.

• #2 Symptoms and complications | Paget’s Association

  https://paget.org.uk/pagets-disease/what-is-pagets-and-how-is-it-managed/symptoms-and-complications/

  Pagets disease can cause bone to become enlarged and misshapen. For example, if the skull is affected, the enlarged bone is sometimes first noticed when the individual becomes aware that their head is larger and their forehead may be wider than normal. Long-standing disease over many years may cause the weight-bearing bones of the leg to develop a bowing deformity. […] If the skull is involved, hearing loss can occur. […] There is an increased risk of fracture, particularly in the long bones of the arm and leg. Fractures may initially be incomplete, (stress fractures or fissure fractures), which are at high risk of complete fracture. Fissure fractures predominantly, but not exclusively, affect weight-bearing bones, such as the thigh bone (femur). […] Pagets disease can predispose to the development of osteoarthritis at adjacent joints.

• #2 Treatment of Paget’s Disease of Bone

  https://www.uspharmacist.com/article/treatment-of-pagets-disease-of-bone

  Headaches and hearing loss may be associated with Pagets disease occurring in the skull. Hearing loss can be sensorineural, mixed, or conductive. […] Neurologic complications, such as spinal cord compression, occur in up to 76% of patients and can produce considerable morbidity. […] The increased bone remodeling resulting from osteoclast-mediated bone resorption followed by disorganized osteoblast-mediated bone deposition can cause pain, fractures, and skeletal deformities.

• #2 Paget’s Disease — Symptoms, Causes, & Treatments | MHA

  https://muscha.org/pagets-disease/

  Pagets disease of bone causes abnormal enlargement and weakening of bone. […] Many people dont realise they have Pagets disease because they dont have any symptoms, or only mild symptoms. […] Depending on how severe your condition is symptoms may include: pain and aching in your bones, affected bones may become deformed or misshapen, affected bones can feel warm, if your skull is affected you may experience problems with hearing, headaches, vertigo or tinnitus. […] For most people Pagets disease progresses slowly and can be managed effectively. However in some cases complications can arise including: osteoarthritis in joints close to bones affected by Pagets disease, the cushioning cartilage on the ends of the bones can break down, causing pain and stiffness, broken bones the new bone growth is weak and fragile, and is more susceptible to fracture than healthy bone, hearing loss caused by pressure on nerves in the ear, numbness or tingling in the spine caused by pinched nerves in the spinal cord, heart disease due to the increased number of blood vessels in the affected bones, your heart has to work harder. This doesnt usually result in heart failure, except in some people who already have heart disease, too much calcium in the blood when several bones have active Pagets Disease, the increase in bone breakdown can lead to an elevated blood calcium level. This is rare, but it can cause symptoms such as: fatigue, weakness, abdominal pain, constipation, loss of appetite.

• #2 Frequently Asked Questions – Bone Health & Osteoporosis Foundation

  https://www.bonehealthandosteoporosis.org/pagets/pagets-frequently-asked-questions/

  The course of Paget’s disease varies greatly and may from completely stable to rapid progression. In general, symptoms progress slowly in affected bones, and there is usually no spread to normal bones. They outlook is generally good, particularly if treatment is given before major changes have occurred. Treatment can control Paget’s disease and lessen symptoms but is not a cure. When untreated, Paget’s disease can cause serious complications, depending on which bones are affected.

• #2 Paget’s Disease of the Bone Symptoms | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/bones-joints-and-muscles/pagets-disease-of-the-bone/symptoms.html

  Most people with Paget’s disease have no symptoms. When symptoms occur, the most common ones are: […] Other symptoms may occur, depending on which part of the body is affected by Paget’s disease. […] If it affects the skull, you may have symptoms such as headaches, sagging face muscles (facial droop), hearing problems, or loose teeth. […] If it affects the spine, it may damage nerves and cause leg pain, numbness, or weakness. It can also cause an emergency condition called cauda equina syndrome that results in loss of feeling in the pelvic area and legs.

• #2 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone/syndicate

  Other symptoms can develop, depending on the bone affected and can include: Headaches and hearing loss when Pagets disease affects the skull. Tingling and numbness in arms and legs when enlarged vertebrae put pressure on the nerves in the spine. Hip pain, which may occur when Pagets disease affects the pelvis or thighbone. […] Depending on the bone or bones affected by Pagets disease, other medical problems can develop, such as: Damage to joint cartilage can lead to arthritis. Changes in the bones of the skull and ear can lead to hearing loss. For some people who have heart disease already and severe Pagets disease, the extra workload of pumping blood throughout the body can lead to heart failure. Enlarged bones in the skull and spine can lead to pressure on the brain, spinal cord, or nerves and reduced blood flow to the brain and spinal cord. When Pagets disease affects the facial bones, the teeth may loosen. This may make chewing more difficult. Rarely, people with Pagets disease can develop bone cancer.

• #2 Paget Disease of Bone – Bone, Joint, and Muscle Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/bone-joint-and-muscle-disorders/paget-disease-of-bone/paget-disease-of-bone

  Bones the upper arm, thigh, or calf may appear bowed and are more likely to break because the bone is weakened by Paget disease. The vertebrae may enlarge, collapse, or both because bones affected by Paget disease are weak. Weakened vertebrae could result in a loss of height, a hunched posture, or pinching of the nerves of the spinal cord, causing pain, numbness, or weakness. […] The most common complication of Paget disease of bone is osteoarthritis (a joint disorder). Osteoarthritis develops in up to 50% of people and develops in joints next to the involved bone. […] Fractures tend to occur more easily than normal at involved bones because these bones are weakened by Paget disease. Such fractures are called pathologic fractures. […] The prognosis for people with Paget disease is most often very good. However, the few people who develop bone cancer have a poor prognosis. People who develop other rare complications, such as heart failure or compression of the spinal cord, may also have a poor prognosis, unless treatment of these complications is timely and successful.

• #2 Paget Disease: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/334607-overview

  Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. Approximately 70-90% of persons with Paget disease are asymptomatic; however, a minority of affected individuals experience various symptoms, including the following: Bone pain (the most common symptom), Secondary osteoarthritis (when Paget disease occurs around a joint), Bony deformity (most commonly bowing of an extremity), Excessive warmth (due to hypervascularity), Neurologic complications (caused by the compression of neural tissues). Paget disease may involve a single bone but is more frequently multifocal. It has a predilection for the axial skeleton (ie, spine, pelvis, femur, sacrum, and skull, in descending order of frequency), but any bone may be affected. After onset, Paget disease does not spread from bone to bone, but it may become progressively worse at preexisting sites. Sarcomatous degeneration of pagetic bone is an uncommon but often deadly complication. Pagetic sarcoma is malignant, and the course usually is rapid and fatal. The general outlook for patients with Paget disease is good, especially if treatment is administered before major changes have occurred in the bones. Treatment does not cure Paget disease, but it can control it. Patients with severe polyostotic Paget disease have a less favorable prognosis than those with monostotic disease. Patients with polyostotic disease are at higher risk for complications. Morbidity from Paget disease can be extensive. The excessive remodeling of bone that occurs may result in pain, fractures, and bone deformities. Additional complications include osteoarthritis, deafness, hydrocephalus, neurologic disease, and osteosarcoma. Complications associated with fractures, such as articular and neurologic problems, may increase mortality in patients with Paget disease. The prognosis is extremely unfavorable if any type of sarcomatous degeneration develops, especially if it is multicentric. The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur.

• #2 Diagnosis and Treatment of Paget’s Disease of Bone | AAFP

  https://www.aafp.org/pubs/afp/issues/2002/0515/p2069.html

  A variety of deformities may occur, including kyphosis; shortened or bowed limbs; leonine facies; frontal bossing of the forehead; dental abnormalities; and, in severe cases, an enlarged cranium that may be difficult to hold erect. […] Neurologic symptoms arise from the compression of nerves, which is caused by osseous growth. […] The incidence of malignant degeneration of pagetic bone ranges from less than 1 percent to 10 percent, depending on disease severity. […] Patients with Paget’s disease may also develop several types of pseudomalignancy, including pseudosarcoma and pseudo giant cell tumors that are responsive to corticosteroids. […] Diagnosis of Paget’s disease may be suspected based on the symptoms, but radiographs are the most specific diagnostic test. […] Although no established standard for initiating therapy exists, the literature generally supports treating the following patients: all symptomatic patients; asymptomatic patients whose biochemical markers suggest an increase in bone remodeling; and patients with pagetic lesions located at weight-bearing regions or adjacent to joints.

• #2 Treatment for Paget’s Disease of the Bone | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/bones-joints-and-muscles/pagets-disease-of-the-bone/treatments.html

  Many people don’t need treatment for Paget’s disease. But even if you don’t need treatment, you will still need to see your doctor on a regular basis from now on. This will let your doctor watch for other problems you might get from the disease, such as arthritis, fractures, or nerve problems. […] Your doctor may prescribe medicine if you have symptoms or if you have no symptoms but you are at risk for other problems from Paget’s disease. Medicine can help reduce the breakdown of bone tissue, control symptoms such as bone pain, and prevent other problems such as arthritis, fractures, or nerve damage. […] Bisphosphonates are usually the first medicines prescribed for Paget’s disease. They often make the disease inactive, sometimes for years or decades. If it becomes active again, you may need to take this medicine off and on to keep the disease under control. […] Some people may need surgery to replace a damaged hip or knee joint.

• #2 Paget’s Disease Symptoms, Causes & Treatment

  https://www.emedicinehealth.com/paget_disease/article_em.htm

  For most people, medical treatment of Paget’s disease can effectively control symptoms, and patients can remain pain free. A small portion of patients can develop more severe symptoms as stated above, including deafness, congestive heart failure, fractures, arthritis, and development of bone tumors (sarcomas). These complications are rare. Most patients remain symptom free and pain free with treatment of the Paget’s disease.

• #3

  https://www.nhs.uk/conditions/pagets-disease-bone/symptoms/

  Symptoms of Paget’s disease of bone include bone or joint pain and problems caused by a nerve being squashed or damaged. […] Paget’s disease may cause pain in the bone itself and in the joints near the affected bone. […] The bone pain is usually dull or aching, deep within the affected part of the body, constant, and worse at night. […] Abnormal bone growth can result in bone squashing (compressing) or damaging a nearby nerve. […] Possible signs of this can include pain travelling from the spine down into your legs (sciatica), numbness or tingling in the affected limbs (peripheral neuropathy), partial loss of movement in your limbs, balance problems, and loss of bowel control (bowel incontinence) or loss of bladder control (urinary incontinence). […] Paget’s disease of bone can also cause a range of other problems, including fragile bones that are more likely to break, osteoarthritis damage to the joints, causing painful and stiff joints, deformities in affected bones, such as curved legs (bow legs) or a curved spine (scoliosis), hearing loss, headaches, vertigo (a spinning sensation) and tinnitus (hearing noises in your ears) these may occur if the skull is affected, and heart problems. […] See a GP if you have persistent bone or joint pain, deformities in any of your bones, or symptoms of a nerve problem, such as numbness, tingling or balance problems.

• #3 Paget Disease: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/334607-overview

  Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. Approximately 70-90% of persons with Paget disease are asymptomatic; however, a minority of affected individuals experience various symptoms, including the following: Bone pain (the most common symptom), Secondary osteoarthritis (when Paget disease occurs around a joint), Bony deformity (most commonly bowing of an extremity), Excessive warmth (due to hypervascularity), Neurologic complications (caused by the compression of neural tissues). Paget disease may involve a single bone but is more frequently multifocal. It has a predilection for the axial skeleton (ie, spine, pelvis, femur, sacrum, and skull, in descending order of frequency), but any bone may be affected. After onset, Paget disease does not spread from bone to bone, but it may become progressively worse at preexisting sites. Sarcomatous degeneration of pagetic bone is an uncommon but often deadly complication. Pagetic sarcoma is malignant, and the course usually is rapid and fatal. The general outlook for patients with Paget disease is good, especially if treatment is administered before major changes have occurred in the bones. Treatment does not cure Paget disease, but it can control it. Patients with severe polyostotic Paget disease have a less favorable prognosis than those with monostotic disease. Patients with polyostotic disease are at higher risk for complications. Morbidity from Paget disease can be extensive. The excessive remodeling of bone that occurs may result in pain, fractures, and bone deformities. Additional complications include osteoarthritis, deafness, hydrocephalus, neurologic disease, and osteosarcoma. Complications associated with fractures, such as articular and neurologic problems, may increase mortality in patients with Paget disease. The prognosis is extremely unfavorable if any type of sarcomatous degeneration develops, especially if it is multicentric. The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur.

• #3 Paget’s Disease of the Bone: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/21929-pagets-disease-of-the-bone

  Many people who have Pagets disease of the bone dont realize that they have it. They may experience no symptoms, or the symptoms may be mild. […] Symptoms of Pagets disease of the bone depend on which bones are affected, and Pagets disease usually gets worse slowly over time if it isnt treated. Symptoms and signs of Pagets disease of the bone can include: […] Bone or joint pain: This could be caused by Pagets disease or by arthritis, which is a complication of Pages disease of the bone. […] Larger head size, bowing of the arm or leg or curvature of the spine: Bone deformations like these can happen in advanced cases of Pagets disease of the bone. […] Bone fractures: Pagets disease can weaken your bones, which makes it more likely that you will experience bone fractures (breaks). […] Headaches and hearing loss: These symptoms can happen if Pagets disease is affecting your skull. […] Pagets disease of the bone is a chronic (lifelong) condition but its treatable. It often gets worse slowly over time if it isnt treated.

• #3 Paget Disease of Bone for Primary Care | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0815/p224.html

  Pain is the major presenting symptom, usually occurring late in the disease process. It is thought to emanate from the osteolytic front of the pagetic lesion, osteoarthritis in joints adjacent to lesions, or from bone deformity and related complications. The pain is typically mild to moderate, relieved by activity, and often worse at night. […] Skeletal deformities result from abnormal bone formation and may manifest as bone enlargement and specific bone deformities. Typical deformities in the long bones may include anterior bowing of the tibia and anterolateral bowing of the femur. Changes in the long bones or spine can alter gait and cause joint and back pain. […] Bone fragility predisposes patients to fractures, and minimal trauma fractures may be the presenting feature. Pain from fractures may be sharp and may be worse on movement or with application of pressure at the site.

• #3 Paget’s disease of bone | Causes, symptoms, treatments

  https://versusarthritis.org/about-arthritis/conditions/pagets-disease-of-bone/

  The parts of the body most likely to be affected are: pelvis, spine, legs, skull, shoulders. […] In time, Pagets disease can lead to a number of other symptoms or complications that can be more serious: Bone expansion: Bone thats affected by Pagets disease expands and may become deformed. Long bones may curve so, for example, one leg may end up shorter than the other. […] Fractures: Bone affected by Pagets disease is weaker than usual, so is more likely to break than healthy bone. It may also take longer than normal for a bone to heal after a fracture. […] Nerve compression: When the bones expand they can sometimes squeeze nearby nerves. This is most likely in the spine, which can lead to weakness and tingling in the legs. […] Deafness: If bones in the head are affected by Pagets disease, it can result in a loss of hearing for example if the bones around the ear become thicker.

• #3 Paget’s Disease of Bone | Orthopedics & Sports Medicine

  https://health.uconn.edu/orthopedics-sports-medicine/conditions-and-treatments/a-z-index/pagets-disease-of-bone/

  Paget’s disease of bone is a chronic disease of the skeleton. It can affect the entire bone or just part of it. In Paget’s disease, osteoclasts are more active than osteoblasts, so there is more bone absorption than normal. The end result is bones that are large and dense, but weak and brittle. The bone is prone to fractures, bowing and deformities. People with Paget’s disease often experience no symptoms at all. For patients who do have symptoms, bone pain is the most common complaint. This pain can be related to active Paget’s disease or its complications which include: fractures of brittle bone, deformity of bone, advanced arthritis of joints near affected bone, loss of sensation or movement caused by compression of nerves near enlarged bones. Fatigue, weakness, loss of appetite, abdominal pain, and constipation are symptoms of a rare complication where elevated calcium levels are found in the blood stream. When pain is severe and unrelenting in an area affected by Paget’s disease, the disease may have degenerated into bone cancer. Paget’s sarcoma occurs in only about 1 percent of patients with Paget’s disease.

• #3 Paget’s Disease: Causes, Symptoms, and Treatments | Arthritis Foundation

  https://www.arthritis.org/diseases/pagets-disease

  This painful condition can cause bones to weaken, become misshapen and fracture more easily. […] The symptoms of Pagets disease depend on which bones are affected. They can include: Pain. Enlarged bones. Broken bones. Damaged cartilage in joints (osteoarthritis). Pinched nerves leading to tingling or numbness (if the disease affects the spine). Hearing loss and headaches (if the disease affects the skull). […] Bones weakened by Pagets may break more easily. The disease may cause fractures, bowed legs, a curved spine or pinched nerves in the spine. Over time, enlarged or misshapen bones can stress nearby joints leading to osteoarthritis in those joints. In very rare cases, Paget’s can turn into a life-threatening cancerous bone disease. Severe Pagets disease may cause damage to the heart.

• #3 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone/syndicate

  Pagets disease of bone is a chronic (long-lasting) disorder that causes bones to grow larger and become weaker than normal. Many people with Pagets disease do not experience symptoms specific to the disease. However, the bone changes can cause: Bone pain. Misshapen bones. Broken bones (fractures). Inflammation and arthritis in the joints close to the affected bones. […] You may not know you have Pagets disease because many people with the disease do not have symptoms. However, fractures or misshapen bones can develop and cause pain. Sometimes, this bone pain, which is the most common symptom of the disease, is mistaken for arthritis or other disorders. Generally, symptoms develop slowly, and the disease does not spread to normal bones. […] In addition, some people with advanced disease may have misshapen bones and other bone changes, which may include: Increase in head size. Bow shape of a limb. Curvature of the spine.

• #3 Paget’s Disease of Bone

  https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/rheumatology/pagets-disease-of-bone/

  PDB is associated with high cardiac output, hypercalcemia, and hyperparathyroidism. High-output heart failure is rare and is a result of increased vascularization of metabolically active pagetic bone. Hypercalcemia is also rare and is normally seen in patients with severe disease who are immobile. Some studies have found an association between PDB and hyperparathyroidism, which could also account for the increase in calcium.

• #3 Paget’s disease of bone | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/pagets-disease-of-bone

  For most people, Paget’s disease of bone progresses slowly and can be managed effectively. However, in some cases, complications can arise including: osteoarthritis in joints close to bones affected by Paget’s disease of bone, the cushioning cartilage on the ends of the bones can break down, causing pain and stiffness, broken bones the new bone growth is weak and fragile, and is more susceptible to fracture than healthy bone, hearing loss caused by pressure on nerves in the ear, numbness or tingling in the spine caused by pinched nerves in the spinal cord, heart disease due to the increased number of blood vessels in the affected bones, the heart has to work harder. This usually does not result in heart failure, except in some people who already have heart disease, too much calcium in the blood when several bones have active Paget’s disease of bone, the increase in bone breakdown can lead to an elevated blood calcium level. This is rare, but it can cause symptoms such as fatigue, weakness, abdominal pain, constipation, loss of appetite.

• #3 Symptoms and complications | Paget’s Association

  https://paget.org.uk/pagets-disease/what-is-pagets-and-how-is-it-managed/symptoms-and-complications/

  Neurological complications can occur, often because of bony overgrowth leading to compression. For example, enlargement of vertebrae in the spine can produce pressure on nerves causing pain, leg weakness or sciatica. […] Should the bone fracture or surgery be undertaken, active Pagets disease has the potential to result in excessive blood loss. This is because blood flow increases to areas where Pagets disease is active. […] Pagets disease does not directly affect the heart but if it is in many bones, is highly active and uncontrolled, the heart may have to work harder to pump extra blood to the affected bones. Whilst heart failure due to this increased blood flow has been reported, it is extremely rare. […] An unusual and very rare complication of Pagets disease is a type of bone cancer called osteosarcoma. This occurs in less than 1:1,000 people with the disease.

• #3 Paget’s disease of bone – myDr.com.au

  https://mydr.com.au/arthritis/paget-s-disease-of-bone/

  If Pagets disease affects the bones of the head, it may cause symptoms such as: Headaches; Loss of hearing, ringing in the ears (tinnitus), or dizziness (vertigo) if the abnormal bone growth presses on the nerves that control hearing; Changes in vision or sense of smell as a result of increased pressure on other nerves in the head; and An enlarged head in the days when most men wore hats, suddenly finding that your hat no longer fits was often the first clue to Pagets disease. […] If Pagets disease affects the bones of the spine, symptoms can include: Pain, numbness, weakness or paralysis in different parts of the body, due to the abnormal bone pressing on or pinching nerves in the spinal cord. […] Less commonly, Pagets disease can affect the heart, because the abnormal new bone needs its own blood supply. The extra demand for blood can put strain on the heart which can lead to heart failure in people who already have heart disease. […] A very rare complication in less than 1% of people with Pagets disease is the development of bone cancer in the abnormal bone. This complication usually only affects people who have had the condition for a long time.

• #3 Paget’s Disease of Bone Information & Treatment

  https://www.columbiadoctors.org/health-library/condition/paget-s-disease-bone/

  Most people with Paget’s disease have no symptoms. When symptoms occur, the most common ones are: […] Bone pain. It may be worse at night and get better with exercise. People often mistake the pain for normal aging or arthritis. […] Deformed bones, such as bowed legs, an enlarged skull or hips, or a curved backbone. […] Broken bones, or fractures. […] Other symptoms may occur, depending on which part of the body is affected by Paget’s disease. […] If it affects the skull, you may have symptoms such as headaches, sagging face muscles (facial droop), hearing problems, or loose teeth. […] If it affects the spine, it may damage nerves and cause leg pain, numbness, or weakness. It can also cause an emergency condition called cauda equina syndrome that results in loss of feeling in the pelvic area and legs.

• #3 Paget’s Disease: What Causes This Chronic Bone Disorder?

  https://www.healthline.com/health/pagets-disease-of-bone

  Pagets disease of the bone is a chronic, progressive condition that involves the bones. It makes the bones break down and regrow quickly, causing weak and misshapen bones. […] In the early stages, Pagets disease of the bone might cause mild or no symptoms. If symptoms do appear, they may include: bone pain, joint pain (especially in the back, hips, and knees), headache, increased size of bones in thighs and lower legs, bowing of bones in thighs and lower legs, increased size of skull in the forehead area. […] The following symptoms might develop in later stages: increased bowing of affected limbs, waddling gait, joint pain, or possibly joint inflammation (arthritis), fractures in affected bones, sensory changes, muscular difficulties, hearing loss (if the skull is affected), misshapen bones, curved spine.

• #3 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone/syndicate

  Other symptoms can develop, depending on the bone affected and can include: Headaches and hearing loss when Pagets disease affects the skull. Tingling and numbness in arms and legs when enlarged vertebrae put pressure on the nerves in the spine. Hip pain, which may occur when Pagets disease affects the pelvis or thighbone. […] Depending on the bone or bones affected by Pagets disease, other medical problems can develop, such as: Damage to joint cartilage can lead to arthritis. Changes in the bones of the skull and ear can lead to hearing loss. For some people who have heart disease already and severe Pagets disease, the extra workload of pumping blood throughout the body can lead to heart failure. Enlarged bones in the skull and spine can lead to pressure on the brain, spinal cord, or nerves and reduced blood flow to the brain and spinal cord. When Pagets disease affects the facial bones, the teeth may loosen. This may make chewing more difficult. Rarely, people with Pagets disease can develop bone cancer.

• #3 Frequently Asked Questions – Bone Health & Osteoporosis Foundation

  https://www.bonehealthandosteoporosis.org/pagets/pagets-frequently-asked-questions/

  The course of Paget’s disease varies greatly and may from completely stable to rapid progression. In general, symptoms progress slowly in affected bones, and there is usually no spread to normal bones. They outlook is generally good, particularly if treatment is given before major changes have occurred. Treatment can control Paget’s disease and lessen symptoms but is not a cure. When untreated, Paget’s disease can cause serious complications, depending on which bones are affected.

• #3 Treatment for Paget’s Disease of the Bone | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/bones-joints-and-muscles/pagets-disease-of-the-bone/treatments.html

  Many people don’t need treatment for Paget’s disease. But even if you don’t need treatment, you will still need to see your doctor on a regular basis from now on. This will let your doctor watch for other problems you might get from the disease, such as arthritis, fractures, or nerve problems. […] Your doctor may prescribe medicine if you have symptoms or if you have no symptoms but you are at risk for other problems from Paget’s disease. Medicine can help reduce the breakdown of bone tissue, control symptoms such as bone pain, and prevent other problems such as arthritis, fractures, or nerve damage. […] Bisphosphonates are usually the first medicines prescribed for Paget’s disease. They often make the disease inactive, sometimes for years or decades. If it becomes active again, you may need to take this medicine off and on to keep the disease under control. […] Some people may need surgery to replace a damaged hip or knee joint.

• #3 Paget’s disease of bone: when and why to refer to specialist care | British Journal of General Practice

  https://bjgp.org/content/70/700/561

  Pagets disease of bone (PDB) is characterised by increased but disorganised bone remodelling, leading to various complications including pain, deformity, and fracture. […] The most common presentation is with bone pain but PDB can also present with bone deformity, deafness, or pathological fractures. […] Referral to secondary care is advisable in a patient thought to have pain or deformity due to PDB so that further assessment can be performed and treatment offered if appropriate. […] Bisphosphonates are the treatment of first choice and are indicated in patients with pain localised to an affected site with evidence of increased metabolic activity. Usually this is manifest by an elevation in ALP but when a single bone is affected the ALP may be normal; here a radionuclide bone scan can be useful in assessing if there is local disease activity. […] Research is now in progress to determine if intervention with bisphosphonates in asymptomatic patients with early disease can halt progression and prevent complications.

• #3 Paget’s Disease of Bone – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/pagets-disease-of-bone

  Paget’s disease of bone is a chronic disease of the skeleton. In healthy bone, a process called remodeling removes old pieces of bone and replaces them with new, fresh bone. Pagets disease causes this process to shift out of balance, resulting in new bone that is abnormally shaped, weak, and brittle. Pagets disease most often affects older people, occurring in approximately 2 to 3% of the population over the age of 55. […] Many patients with Pagets disease have no symptoms at all and are unaware they have the disease until X-rays are taken for some other reason. When bone pain and other symptoms are present, they can be related to the disease itself or to complications that arise from the disease such as arthritis, bone deformity, and fractures. […] In patients who do have symptoms, bone pain is the most common complaint. This pain can be related to active Paget’s disease or to its complications, which include: Fractures due to brittle bone. Deformity of bone, including bowing of the affected bone. Advanced arthritis in joints near the affected bone. Compression on neighboring nerves from enlarged bones, leading to a loss of sensation or movement.

• #3 Paget’s Disease of the Bone Symptoms & Causes | Baptist Health

  https://cd.baptisthealth.com/care-services/conditions-treatments/pagets-disease-of-the-bone

  If Paget’s disease affects your skull, you can experience hearing issues or hearing loss. […] Damaged cartilage and excess pressure on your joints can cause arthritis. […] Paget’s disease usually progresses slowly. Therefore, most individuals living with Paget’s disease find that the condition is manageable with few complications. However, complications are possible. […] Paget’s disease prognosis is generally optimistic. The outcome of treatment depends on many factors, including your age, health, and the severity of the condition. A healthy diet and exercise can further help strengthen your bones and improve your quality of life.

• #4 Paget’s disease of bone: Symptoms, causes, and treatment

  https://www.medicalnewstoday.com/articles/177668

  Pagets disease is the second most common type of bone disease after osteoporosis. It is a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone. […] This process can lead to weakness in the bones, bone pain, arthritis, deformities, and fractures. Many people with Pagets disease do not realize that they have it, as symptoms are often either mild or undetectable. […] The most common symptoms that occur relate to bone or joint pain. Other symptoms include swelling of joints, tenderness, or redness of the skin that covers the areas affected by Pagets disease. […] Some people only become aware of their presentation of Pagets disease after experiencing a fracture in a weakened bone. […] Pagets disease most commonly occurs in the following bones: the pelvis, the spine, the skull, the femur, or thighbone, the tibia, or shin bone.

• #4 Paget’s disease of bone – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pagets-disease-of-bone/diagnosis-treatment/drc-20350816

  Paget’s disease of bone often causes the body to produce too many blood vessels in the affected bones, increasing the risk of serious blood loss during an operation. […] Most people with Paget’s disease of bone don’t have any symptoms and are diagnosed when an X-ray or blood test taken for another reason reveals signs of Paget’s disease of bone.

• #4 Paget’s disease | Healthify

  https://healthify.nz/health-a-z/p/pagets-disease/

  Paget’s disease is a chronic (long-term) condition causing bones to be enlarged and weakened. This can cause pain and aching. […] For people who do get symptoms, bone pain is most common. This type of pain is usually described as a dull, continuous pain deep within the affected part of the body. It is often worse with rest and at night. The area may also feel warm. […] Pain in the joints may occur when abnormal bone growth causes arthritis in the joint. Some people also get numbness and tingling, shooting pains and balance problems because of bone growth squashing a nerve. […] Other symptoms include enlarged or misshapen bones, bowed legs, problems with hearing, headaches, and bones that break easily. […] There’s no cure for Pagets disease, but treatment can help manage the symptoms.

• #4 Paget’s Disease: What Causes This Chronic Bone Disorder?

  https://www.healthline.com/health/pagets-disease-of-bone

  Pagets disease of the bone is a chronic, progressive condition that involves the bones. It makes the bones break down and regrow quickly, causing weak and misshapen bones. […] In the early stages, Pagets disease of the bone might cause mild or no symptoms. If symptoms do appear, they may include: bone pain, joint pain (especially in the back, hips, and knees), headache, increased size of bones in thighs and lower legs, bowing of bones in thighs and lower legs, increased size of skull in the forehead area. […] The following symptoms might develop in later stages: increased bowing of affected limbs, waddling gait, joint pain, or possibly joint inflammation (arthritis), fractures in affected bones, sensory changes, muscular difficulties, hearing loss (if the skull is affected), misshapen bones, curved spine.

• #4 Paget’s Disease of Bone – Symptoms & Causes| NIAMS

  https://www.niams.nih.gov/health-topics/pagets-disease-bone/syndicate

  Other symptoms can develop, depending on the bone affected and can include: Headaches and hearing loss when Pagets disease affects the skull. Tingling and numbness in arms and legs when enlarged vertebrae put pressure on the nerves in the spine. Hip pain, which may occur when Pagets disease affects the pelvis or thighbone. […] Depending on the bone or bones affected by Pagets disease, other medical problems can develop, such as: Damage to joint cartilage can lead to arthritis. Changes in the bones of the skull and ear can lead to hearing loss. For some people who have heart disease already and severe Pagets disease, the extra workload of pumping blood throughout the body can lead to heart failure. Enlarged bones in the skull and spine can lead to pressure on the brain, spinal cord, or nerves and reduced blood flow to the brain and spinal cord. When Pagets disease affects the facial bones, the teeth may loosen. This may make chewing more difficult. Rarely, people with Pagets disease can develop bone cancer.

• #4 Paget Disease: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/334607-overview

  Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation. This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. Approximately 70-90% of persons with Paget disease are asymptomatic; however, a minority of affected individuals experience various symptoms, including the following: Bone pain (the most common symptom), Secondary osteoarthritis (when Paget disease occurs around a joint), Bony deformity (most commonly bowing of an extremity), Excessive warmth (due to hypervascularity), Neurologic complications (caused by the compression of neural tissues). Paget disease may involve a single bone but is more frequently multifocal. It has a predilection for the axial skeleton (ie, spine, pelvis, femur, sacrum, and skull, in descending order of frequency), but any bone may be affected. After onset, Paget disease does not spread from bone to bone, but it may become progressively worse at preexisting sites. Sarcomatous degeneration of pagetic bone is an uncommon but often deadly complication. Pagetic sarcoma is malignant, and the course usually is rapid and fatal. The general outlook for patients with Paget disease is good, especially if treatment is administered before major changes have occurred in the bones. Treatment does not cure Paget disease, but it can control it. Patients with severe polyostotic Paget disease have a less favorable prognosis than those with monostotic disease. Patients with polyostotic disease are at higher risk for complications. Morbidity from Paget disease can be extensive. The excessive remodeling of bone that occurs may result in pain, fractures, and bone deformities. Additional complications include osteoarthritis, deafness, hydrocephalus, neurologic disease, and osteosarcoma. Complications associated with fractures, such as articular and neurologic problems, may increase mortality in patients with Paget disease. The prognosis is extremely unfavorable if any type of sarcomatous degeneration develops, especially if it is multicentric. The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur.

• #4 Paget Disease of Bone – Bone, Joint, and Muscle Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/bone-joint-and-muscle-disorders/paget-disease-of-bone/paget-disease-of-bone

  Paget disease of bone is a chronic disorder of the skeleton in which areas of bone undergo abnormal turnover, resulting in areas of enlarged and softened bone. […] Symptoms may be absent or may include bone pain, bone deformity, arthritis, and painful nerve compression. […] Paget disease usually causes no symptoms. However, bone pain, bone enlargement, or bone deformity may occur. Bone pain may be deep, aching, and occasionally severe and may worsen at night. The enlarging bones may compress nerves, causing more pain. If osteoarthritis occurs, joints become painful and stiff. […] The skull may enlarge, and the brow and forehead may look more prominent (called frontal bossing). A person may notice this enlargement when a larger hat is needed. Enlarged skull bones may damage the inner ear (cochlea), which can cause hearing loss, and dizziness. The enlarged skull bones can compress nerves, which causes headaches.

• #4 Paget’s Disease of the Spine | We treat patients with this condition

  https://scoliosisinstitute.com/pagets-disease-of-the-spine/

  Pagets disease of the spine, also known as osteitis deformans, refers to a chronic bone disorder characterized by abnormal bone remodeling in the spine. This results in excessive breakdown and regrowth of bone, leading to enlarged, misshapen, and weakened vertebrae. […] Symptoms of Pagets disease of the spine can vary but often include bone pain, stiffness, and an increased risk of fractures. Nerve compression due to bone deformities may result in symptoms such as tingling, numbness, or weakness in the affected areas. Changes in posture and spinal curvature are also common manifestations of advanced Pagets disease. […] Complications of Pagets disease of the spine include chronic pain, fractures due to weakened bones, nerve compression leading to neurological symptoms, and deformities that can impact posture and mobility. In severe cases, complications may extend to the development of osteoarthritis, hearing loss if the skull is affected, and, rarely, the transformation of affected bones into bone cancer.

• #4 Paget’s Disease Cypress TX | Hip Pain Cypress | Osteoporosis Houston TX

  https://www.advancedosm.com/pagets-disease/

  Paget’s disease of bone is a chronic condition characterized by abnormal bone remodeling, leading to enlarged and weakened bones. This disorder can cause pain, deformities, and an increased risk of fractures. […] Pagets disease is a condition that interferes with the bodys normal bone recycling process, causing new bone tissue to be produced much faster than needed to replace old bone tissue. This accelerated bone remodeling produces bone tissue that is softer and weaker than normal, which can lead to bone pain, an increased risk of fractures and other complications. Over time, Pagets disease can also cause arthritis if an enlarged bone presses on a nearby joint. […] Pagets Disease does not always produce symptoms, and when it does, the symptoms can vary depending on which bones are affected: Pelvis Hip pain, Skull Headaches and hearing loss, increasing hat size, Spine Pain, numbness and tingling sensations that travel down an arm or leg, Legs Bowed legs and osteoarthritis in the hips and knees.

Zobacz więcej