Materiały źródłowe

• #1 Paget’s Disease of the Breast: Stages, Symptoms & Prognosis

  https://my.clevelandclinic.org/health/diseases/17913-pagets-disease-of-the-breast

  Breast cancer survival is based on the stage of the cancer when its detected. If you only have Paget’s disease of the nipple or ductal carcinoma in situ (stage 0) that hasnt spread beyond the milk ducts, your prognosis is excellent. Most people who discover and treat these conditions early will make a full recovery. Once breast cancer begins to spread, it becomes progressively harder to beat. […] Paget’s disease of the breast is early-stage breast cancer of the milk ducts that occurs in the nipple. Its sometimes accompanied by more invasive breast cancer. You may notice nipple changes such as crusting, flaking of the skin, discharge or a raw area that doesnt heal. The earlier you identify and treat it, the better your outcome will be. Many people make a full recovery, but it will require surgery to remove it.

• #1

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  Paget disease of the breast is an uncommon malignant tumor with an inferior outcome. Therefore, establishing nomograms to predict the survival outcomes of breast Paget disease patients is urgent. Tumor grade, histological type, American Joint Committee on Cancer (AJCC) stage, surgery, chemotherapy, and marital status were confirmed as independent overall survival (OS)-related factors; tumor grade, histological type, AJCC stage, and age were associated with independent cancer-specific survival (CSS)-related factors. The values of the C-index for OS nomogram acquired were 0.827 and 0.745 for training and validation cohorts, respectively. Meanwhile, the corresponding values of the C-index to CSS nomogram were 0.890 and 0.655, respectively. In conclusion, two valuable nomograms incorporating various clinicopathological indicators were established for breast Paget disease patients. These prognostic nomograms provide accurate prognostic assessment for breast Paget disease patients and help clinicians select appropriate treatment strategies.

• #1 Paget’s Disease of the Breast: Symptoms, Treatment & Prognosis

  https://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/pagets-disease-of-the-breast

  Survival rates differ depending on the severity of Pagets disease. The five-year relative survival rate for women with Pagets disease in the United States between 1988 and 2001 was 82.6 percent, according to the NCI. […] As current treatments change, the overall outlook may improve. […] Since Pagets disease is rare, randomized controlled clinical trials are hard to perform. But patients researching this option have a database available of NCI-supported clinical trials.

• #1 Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6010794/

  The outcomes of these subtypes of breast carcinoma were different. Based on the overall survival, the patients with PDIDC had the worst prognosis (5-year survival rate = 84.1%). The PDDCIS had the best prognosis (5-year survival rate = 97.5%). […] Among three subtypes of Paget disease, patients with PDIDC had the worst prognosis. Besides, patients who were unmarried had worse outcomes. […] Patients with PDDCIS had the best prognosis with a 5-year OS of 83.6%. The one worse than the PDDCIS was IDC. The 5-year OS of patients with IDC was 81.1%. Then, the next one was PD. The 5-year OS of patients with PD was 72.9%. The one with worst outcomes was PDIDC, whose 5-year OS was 71.4%. […] The patients with PDDCIS had the best prognosis with a 5-year survival rate of 98.2%. The worse one was patients with PD. Its 5-year survival rate was 92.4%. The survival rate of patients with IDC was 91%. And patients who were diagnosed with PDIDC had the worst outcomes. Its 5-year survival rate was 84.1%. […] The observation underscores the importance of individualized treatment.

• #1 Paget Disease of the Breast – NCI

  https://www.cancer.gov/types/breast/paget-breast-fact-sheet

  What is the prognosis for people with Paget disease of the breast? […] The prognosis, or outlook, for people with Paget disease of the breast depends on a variety of factors, including the following: […] The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival. […] According to NCIs Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent) (1, 3, 8, 9).

• #1 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  The factor that plays the most significant role in determining the outcome is early diagnosis. By the time there is a large mass or the cancer has spread to lymph nodes, the disease is more advanced and has a worse prognosis. […] The outlook for Pagets disease of the breast will depend on various factors, such as whether there is a tumor, which type of cancer a person has, and social and environmental factors. […] According to data from 2000 to 2013, the overall 5-year survival rate for Pagets disease of the breast with DCIS was 97.5%. […] The overall survival rate after 5 years for those with a different type of underlying cancer, concomitant infiltrating duct carcinoma, was less, at 84.1%. […] However, each case is unique. The type, stage, and location of the cancer can all influence a persons outlook, as well as their age and overall health.

• #1 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast/

  Treatment aims to remove the area of Pagets disease from your breast and reduce the risk of it coming back or spreading to other parts of the body. […] If you have invasive breast cancer in addition to Pagets disease, you may be given some treatments before surgery. This is known as neo-adjuvant or primary treatment. […] Most breast cancers dont come back after treatment. But sometimes it can return, so its important you know what signs and symptoms to look out for.

• #1 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  It is also important to remember that cancer treatment is constantly evolving. Today, over 10 years later, survival rates may be better than these figures suggest. […] Although Pagets disease of the breast is more common in white people, Black people in the United States have more negative outcomes. […] This suggests that structural inequity is influencing the outcomes for Black people with this disease. […] With early diagnosis and treatment, Pagets disease of the breast is typically curable.

• #1

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  Breast Paget disease is a rare subtype of breast cancer. Unfortunately, its prognosis is worse than other types of breast cancers. Many risk factors and prognostic variables have been identified, but there is no thorough research focused on developing the prognostic prediction tools for breast Paget disease, which indicates that the probability of prognosis cannot be well assessed. […] In our research, age was confirmed as an independent prognostic factor for breast PD patients. As a clinical indicator not incorporated into the AJCC stage system, age is strongly associated with patients prognosis, including breast cancer. The poor outcomes of elderly patients are related to the clinical course of the disease and related to comorbidities. In addition, due to poorly characterized functional status or weakened immune response, less active treatment was performed, resulting in a relatively poor prognosis. Marital status was confirmed as another independent prognostic factor for breast PD patients. Married breast PD patients showed a better prognosis. Additionally, previous studies had also found that married cancer patients have a survival advantage and a reduced risk of death. This relationship may be attributed to the vital role of marital status in regulating the function of the endocrine system and immune system.

• #1

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  In summary, we used routine clinical data to construct and validate nomograms of PD patients at one year, three-, and five years. Compared with individual prognostic factors, the nomogram scoring systems had better distinguishing ability and clinical application value. This is very useful for promoting individualized therapy and management of breast PD patients.

• #1 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast/

  Pagets disease of the breast is an uncommon type of breast cancer. […] Most people with Pagets disease will have an early form of breast cancer called ductal carcinoma in situ (DCIS) under the nipple or elsewhere in the breast. DCIS means cancer cells have developed within the milk ducts but have not yet developed the ability to spread outside of the ducts into the surrounding breast tissue or to other parts of the body. As a result, DCIS has a good outlook (prognosis) when treated. […] Although the size and grade of the DCIS may help predict if it will become invasive, theres currently no way of knowing for certain if this will happen. […] Some people with Pagets disease will also have an underlying invasive breast cancer. Invasive breast cancer has the potential to spread from the breast to other parts of the body.

• #2

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  Paget disease of the breast is an uncommon malignant tumor with an inferior outcome. Therefore, establishing nomograms to predict the survival outcomes of breast Paget disease patients is urgent. Tumor grade, histological type, American Joint Committee on Cancer (AJCC) stage, surgery, chemotherapy, and marital status were confirmed as independent overall survival (OS)-related factors; tumor grade, histological type, AJCC stage, and age were associated with independent cancer-specific survival (CSS)-related factors. The values of the C-index for OS nomogram acquired were 0.827 and 0.745 for training and validation cohorts, respectively. Meanwhile, the corresponding values of the C-index to CSS nomogram were 0.890 and 0.655, respectively. In conclusion, two valuable nomograms incorporating various clinicopathological indicators were established for breast Paget disease patients. These prognostic nomograms provide accurate prognostic assessment for breast Paget disease patients and help clinicians select appropriate treatment strategies.

• #2 Paget Disease of the Breast – NCI

  https://www.cancer.gov/types/breast/paget-breast-fact-sheet

  What is the prognosis for people with Paget disease of the breast? […] The prognosis, or outlook, for people with Paget disease of the breast depends on a variety of factors, including the following: […] The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival. […] According to NCIs Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent) (1, 3, 8, 9).

• #2

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  Breast Paget disease is a rare subtype of breast cancer. Unfortunately, its prognosis is worse than other types of breast cancers. Many risk factors and prognostic variables have been identified, but there is no thorough research focused on developing the prognostic prediction tools for breast Paget disease, which indicates that the probability of prognosis cannot be well assessed. […] In our research, age was confirmed as an independent prognostic factor for breast PD patients. As a clinical indicator not incorporated into the AJCC stage system, age is strongly associated with patients prognosis, including breast cancer. The poor outcomes of elderly patients are related to the clinical course of the disease and related to comorbidities. In addition, due to poorly characterized functional status or weakened immune response, less active treatment was performed, resulting in a relatively poor prognosis. Marital status was confirmed as another independent prognostic factor for breast PD patients. Married breast PD patients showed a better prognosis. Additionally, previous studies had also found that married cancer patients have a survival advantage and a reduced risk of death. This relationship may be attributed to the vital role of marital status in regulating the function of the endocrine system and immune system.

• #2 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  The factor that plays the most significant role in determining the outcome is early diagnosis. By the time there is a large mass or the cancer has spread to lymph nodes, the disease is more advanced and has a worse prognosis. […] The outlook for Pagets disease of the breast will depend on various factors, such as whether there is a tumor, which type of cancer a person has, and social and environmental factors. […] According to data from 2000 to 2013, the overall 5-year survival rate for Pagets disease of the breast with DCIS was 97.5%. […] The overall survival rate after 5 years for those with a different type of underlying cancer, concomitant infiltrating duct carcinoma, was less, at 84.1%. […] However, each case is unique. The type, stage, and location of the cancer can all influence a persons outlook, as well as their age and overall health.

• #2 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast/

  Pagets disease of the breast is an uncommon type of breast cancer. […] Most people with Pagets disease will have an early form of breast cancer called ductal carcinoma in situ (DCIS) under the nipple or elsewhere in the breast. DCIS means cancer cells have developed within the milk ducts but have not yet developed the ability to spread outside of the ducts into the surrounding breast tissue or to other parts of the body. As a result, DCIS has a good outlook (prognosis) when treated. […] Although the size and grade of the DCIS may help predict if it will become invasive, theres currently no way of knowing for certain if this will happen. […] Some people with Pagets disease will also have an underlying invasive breast cancer. Invasive breast cancer has the potential to spread from the breast to other parts of the body.

• #2 Paget’s Disease of the Breast: Symptoms, Treatment & Prognosis

  https://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/pagets-disease-of-the-breast

  Survival rates differ depending on the severity of Pagets disease. The five-year relative survival rate for women with Pagets disease in the United States between 1988 and 2001 was 82.6 percent, according to the NCI. […] As current treatments change, the overall outlook may improve. […] Since Pagets disease is rare, randomized controlled clinical trials are hard to perform. But patients researching this option have a database available of NCI-supported clinical trials.

• #2

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8851527/

  In summary, we used routine clinical data to construct and validate nomograms of PD patients at one year, three-, and five years. Compared with individual prognostic factors, the nomogram scoring systems had better distinguishing ability and clinical application value. This is very useful for promoting individualized therapy and management of breast PD patients.

• #2 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast

  Treatment aims to remove the area of Pagets disease from your breast and reduce the risk of it coming back or spreading to other parts of the body. […] Surgery is usually the first treatment for Pagets disease of the breast. Its often the only treatment youll need if you have Pagets disease without DCIS or invasive breast cancer. […] If you have invasive breast cancer in addition to Pagets disease, you may be given some treatments before surgery. This is known as neo-adjuvant or primary treatment. […] Most breast cancers dont come back after treatment. But sometimes it can return, so its important you know what signs and symptoms to look out for.

• #2 Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6010794/

  The outcomes of these subtypes of breast carcinoma were different. Based on the overall survival, the patients with PDIDC had the worst prognosis (5-year survival rate = 84.1%). The PDDCIS had the best prognosis (5-year survival rate = 97.5%). […] Among three subtypes of Paget disease, patients with PDIDC had the worst prognosis. Besides, patients who were unmarried had worse outcomes. […] Patients with PDDCIS had the best prognosis with a 5-year OS of 83.6%. The one worse than the PDDCIS was IDC. The 5-year OS of patients with IDC was 81.1%. Then, the next one was PD. The 5-year OS of patients with PD was 72.9%. The one with worst outcomes was PDIDC, whose 5-year OS was 71.4%. […] The patients with PDDCIS had the best prognosis with a 5-year survival rate of 98.2%. The worse one was patients with PD. Its 5-year survival rate was 92.4%. The survival rate of patients with IDC was 91%. And patients who were diagnosed with PDIDC had the worst outcomes. Its 5-year survival rate was 84.1%. […] The observation underscores the importance of individualized treatment.

• #2 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast

  Pagets disease of the breast is an uncommon type of breast cancer. […] Most people with Pagets disease will have an early form of breast cancer called ductal carcinoma in situ (DCIS) under the nipple or elsewhere in the breast. DCIS means cancer cells have developed within the milk ducts but have not yet developed the ability to spread outside of the ducts into the surrounding breast tissue or to other parts of the body. As a result, DCIS has a good outlook (prognosis) when treated. […] Although the size and grade of the DCIS may help predict if it will become invasive, theres currently no way of knowing for certain if this will happen. […] Some people with Pagets disease will also have an underlying invasive breast cancer. Invasive breast cancer has the potential to spread from the breast to other parts of the body.

• #3 Paget Disease of the Breast – NCI

  https://www.cancer.gov/types/breast/paget-breast-fact-sheet

  What is the prognosis for people with Paget disease of the breast? […] The prognosis, or outlook, for people with Paget disease of the breast depends on a variety of factors, including the following: […] The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival. […] According to NCIs Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent) (1, 3, 8, 9).

• #3 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  The factor that plays the most significant role in determining the outcome is early diagnosis. By the time there is a large mass or the cancer has spread to lymph nodes, the disease is more advanced and has a worse prognosis. […] The outlook for Pagets disease of the breast will depend on various factors, such as whether there is a tumor, which type of cancer a person has, and social and environmental factors. […] According to data from 2000 to 2013, the overall 5-year survival rate for Pagets disease of the breast with DCIS was 97.5%. […] The overall survival rate after 5 years for those with a different type of underlying cancer, concomitant infiltrating duct carcinoma, was less, at 84.1%. […] However, each case is unique. The type, stage, and location of the cancer can all influence a persons outlook, as well as their age and overall health.

• #3 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  It is also important to remember that cancer treatment is constantly evolving. Today, over 10 years later, survival rates may be better than these figures suggest. […] Although Pagets disease of the breast is more common in white people, Black people in the United States have more negative outcomes. […] This suggests that structural inequity is influencing the outcomes for Black people with this disease. […] With early diagnosis and treatment, Pagets disease of the breast is typically curable.

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