Materiały źródłowe

• #1 Paget’s disease of the breast | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/pagets-disease-breast

  Paget’s disease of the breast affects your nipple and usually the skin (areola) surrounding it. It’s easy to mistake the signs and symptoms of Paget’s disease of the breast for skin irritation (dermatitis) or another noncancerous (benign) skin condition. […] Possible signs and symptoms of Paget’s disease of the breast include: Flaky or scaly skin on your nipple, Crusty, oozing or hardened skin resembling eczema on the nipple, areola or both, Itching, Redness, A tingling or burning sensation, Straw-colored or bloody nipple discharge, A flattened or turned-in (inverted) nipple, A lump in the breast, Thickening skin on the breast. […] Signs and symptoms usually occur in one breast only. The disease typically starts in the nipple and may spread to the areola and other areas of the breast. […] The skin changes may come and go early on or respond to topical treatment, making it appear as if your skin is healing. On average, signs and symptoms occur for several months before a diagnosis is made.

• #2 Paget’s Disease of the Breast: Stages, Symptoms & Prognosis

  https://my.clevelandclinic.org/health/diseases/17913-pagets-disease-of-the-breast

  Paget’s disease of the breast resembles eczema on your nipple and may be mistaken for an ordinary rash at first. It may cause itching and scaling, red or raised plaques on your skin and discharge from the nipple. Most people who have these symptoms dont have Paget’s disease. However, if you do, these may be the first noticeable signs of underlying breast cancer. […] Symptoms affect your nipple and/or areola. They usually only affect one breast, but rarely, they may affect both. They may appear to come and go at first but eventually worsen. Symptoms can include: Nipple itching that can turn to burning. Dry skin, flaking or scaling of the nipple or areola. Skin rash that might be red, raised, crusting, raw or bleeding. Inflammation and soreness. Crusting and oozing resembling weeping eczema. Bloody or pus-like nipple discharge. Flat or inverted nipple. Palpable breast lump under the skin.

• #3

  https://www.nhs.uk/conditions/pagets-disease-nipple/

  Paget’s disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. […] The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated. […] Around half of all women diagnosed with Paget’s disease of the nipple have a lump behind the nipple. In 9 out of 10 cases this is an invasive breast cancer. […] Some women with Paget’s disease have invasive breast cancer but do not have a lump. […] However, most women with Paget’s disease who do not have a lump have non-invasive cancer. This is where the cancerous cells are contained in 1 or more areas of the breast and have not spread.

• #4 Paget’s disease of the breast | Breast cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/breast-cancer/types/pagets-disease-breast

  Paget’s disease of the breast is a rare condition of the nipple that is associated with some breast cancers. It usually first appears as a red, scaly rash of the skin over the nipple and areola. It can be itchy, painful or cause a burning sensation. You might have some discharge or bleeding from the nipple. Or the nipple can change in appearance, going inwards when it wasn’t inverted before. […] Paget’s disease is a sign that there might be breast cancer in the tissues behind the nipple. About half of the people diagnosed with Paget’s disease of the breast have a lump behind the nipple. Most people with a lump behind the nipple are found to have invasive breast cancer. […] But most people with Paget’s disease of the breast who have no lump behind the nipple, have ductal carcinoma in situ (DCIS). This means that some cells have started to turn into cancer but they are completely contained within the lining of the breast ducts.

• #5 Paget’s Disease of the Breast: Symptoms, Diagnosis, Treatment, and Prevention

  https://www.webmd.com/breast-cancer/pagets-nipple-disease

  Early symptoms include redness, light scaling, and flaking of the skin on your nipple. You might have only mild irritation, not enough to send you to the doctor. Your skin could get better on its own. This doesnt mean the disease has gone away. […] Further symptoms can be a sign of serious damage to your skin. You might notice: Tingling, Itching, More sensitivity, Burning, Pain, Bloody or yellowish discharge from your nipple, Oozing or bleeding areas, A nipple that looks flattened against your breast, Thickened skin in the nipple area, A lump or mass in your breast. […] In most cases, the disease starts in the nipple and then spreads to the areola (the circular area of darker skin that surrounds it) or other areas of your breast. Sometimes, it affects only the areola, where it can look like eczema, an itchy red rash. […] Rarely, this condition can affect both breasts.

• #6 Paget’s Disease of the Breast Explained

  https://resources.healthgrades.com/right-care/womens-health/pagets-disease-of-the-breast

  Early symptoms of Paget’s disease may also improve over time and then flare up again. The first changes you may notice around your nipple or areola are: redness or discoloration, scaling, crusting, thickened patches. […] Other symptoms can include: a yellow discharge from your nipple, an itching or burning feeling, blood from the nipple or the areola, pain, flaky skin, inflammation, a flat or inverted nipple. […] Paget’s disease of the breast is a rare form of cancer that affects the nipple and often the areola. Symptoms include redness, itching, and inflammation. For many females, it produces a lump in the breast. It can occur in males. However, it most commonly occurs in females over the age of 50.

• #7

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/pagets-disease-breast

  Paget’s disease of the breast, often referred to as Pagets disease of the nipple, is a rare type of breast cancer that affects the skin on your nipple. […] Paget’s disease of the breast is a rare form of breast cancer that primarily affects the skin of the nipple and often spreads to the areola, the darker area around the nipple. This condition can easily be mistaken for more benign skin issues like eczema or dermatitis. […] However, Paget’s disease of the breast often indicates an underlying breast cancer, such as ductal carcinoma in situ (DCIS) or invasive breast cancer. […] Early symptoms of Pagets disease of the breast might be subtle and easily ignored. Regular self-exams and monitoring for any changes in the skin of your nipple and areola can aid in early detection, improving the chances of successful treatment.

• #8

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/pagets-disease-breast

  Here are the main signs to look out for: Skin changes in the nipple and areola: You might see redness, flaking or crusting of the skin on your nipple and areola. These symptoms can be mistaken for eczema but dont improve with typical skin treatments. […] The progression of Paget’s disease of the breast can vary widely. It can develop slowly over several months or years. It can also progress more quickly, especially if associated with underlying invasive breast cancer.

• #9 Paget’s Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/breast-cancer/guide/paget-disease/

  Pagets disease of the breast also known as Pagets disease of the nipple, mammary Pagets disease, or sometimes Pagets nipple disease is a rare form of breast cancer that affects the skin of the nipple and usually the surrounding areola (the darker circle of skin around the nipple). Its usually only found in one breast. […] The symptoms of Pagets disease appear on the nipple and usually the areola. Most often, they occur on one breast, but they can also occur on both breasts. These symptoms include: Itching or burning on the nipple, Crusting or oozing skin on the nipple or areola, Flaky or scaly skin on the nipple, Newly flattened or turned-in (inverted) nipple, A rash that can appear discolored, raised, or raw on the nipple area, Yellow or bloody nipple discharge. […] Complicating matters, the symptoms of Pagets disease may appear to improve at first or respond to topical treatment, which can lead some people to think the skin is healing. Eventually though, the symptoms will worsen.

• #10 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  Pagets disease of the breast or nipple involves dry skin, flaking, or changes in the color or shape of the nipple. It may look like eczema or psoriasis, but it can be a sign of breast cancer. […] The symptoms of Pagets disease of the breast can resemble those of a skin condition, such as eczema or psoriasis. This sometimes delays diagnosis, increasing the risk of the condition advancing. […] Pagets disease of the breast causes skin symptoms on the breasts or nipples because of underlying breast cancer. In 80% to 90% of people with Pagets disease of the breast, the underlying cancer is either ductal carcinoma in situ (DCIS) or invasive breast cancer. […] The symptoms of Pagets disease vary depending on the stage of development. […] The most common symptoms include: itching, tingling, or burning around the nipple and areola; skin discoloration; flaking, thickening, or scaling of the skin around the nipple that does not heal over time; nipple discharge, which may be yellow or contain blood; flattened or inverted nipples; a crusted lesion with irregular edges; a mass in the nipple; ulceration, in some cases.

• #11 Mammary Paget’s Disease: An Update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9139704/

  MPD skin changes of the nipple and/or areola may resemble eczema with a fine scaling erythematous rash or a flaky, fissured, bleeding rash in more established cases. […] Advanced cases are often accompanied by skin ulceration and nipple retraction. […] In 98% (217) of the patients, the main presenting symptom was eczema or ulceration of the nipple. […] In the early stages, however, the nipple appears to be normal, but the patient might present with mild symptoms such as nipple pruritus. […] MPD-associated skin surface changes slowly progress, producing a dermatitictous appearance affecting the nipple, areola, and eventually the skin of the breast. […] Commonly, MPD is initially misdiagnosed as eczema, dermatitis, or psoriasis, which accounts for the frequent delay in diagnosis. […] Consequently, to avoid a delayed diagnosis, any suspected signs or symptoms of eczematoid, pigmented, crusted, or scaly lesions or chronic inflammation in the nipple should be confirmed with biopsy.

• #12 Paget disease (breast) | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/paget-disease-breast?lang=us

  Paget disease of the breast, which is also known as Paget disease of the nipple, has traditionally been described as a form of breast malignancy characterized by infiltration of the nipple epidermis by malignant cells. […] Eczematous appearing changes of the nipple include reddening, scaling, hyperkeratosis, and crusting of the nipple surface. […] In most cases of Paget of the breast, there are malignant ductal cells that extend to the nipple surface through the terminal lactiferous ducts. […] Malignant epithelial (Paget) cells infiltrate and proliferate in the epidermis, causing an eczema-like rash of the nipple and the areolar skin. […] Mammary Paget disease can be classified into four clinical stages: stage 0: lesion is confined to the epidermis, without underlying ductal carcinoma in situ (DCIS) of the breast; stage 1: associated with DCIS just beneath the nipple; stage 2: associated with extensive DCIS; stage 3: associated with invasive ductal carcinoma. […] Traditionally, treatment has been a mastectomy with nodal dissection. However, with MRI, breast-conserving therapy is more frequently being used.

• #13 Paget’s Disease of the Breast: Symptoms, Treatment & Prognosis

  https://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/pagets-disease-of-the-breast

  Pagets disease of the breast affects about 1 to 4 percent of breast cancer patients, according to the National Cancer Institute (NCI). It’s a rare type of breast cancer that forms in the nipple and areola (the darker, pigmented skin surrounding the nipple). […] In most cases, Pagets disease affects one breast, and the symptoms may come and go. This means symptoms may cycle through, appearing to improve and then worsen again. The symptoms may look similar to eczema or other such skin conditions. Patients may notice: Patches of thickened skin on the nipple or surrounding skin, Itching or tingling in the nipple or areola, Yellow or bloody discharge in the nipple or areola, A nipple that looks flaky, crusty or red, A nipple that appears to be flattened or inverted, meaning it caves inward. […] Survival rates differ depending on the severity of Pagets disease. The five-year relative survival rate for women with Pagets disease in the United States between 1988 and 2001 was 82.6 percent, according to the NCI. As current treatments change, the overall outlook may improve.

• #14 Paget Disease of the Breast | Details, Diagnosis and Signs | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/paget-disease-of-the-nipple.html

  Paget disease of the breast is a rare type of breast cancer involving the skin of the nipple and the areola (the dark circle around the nipple). […] The skin of the nipple and areola often looks crusted, scaly, and red. There may be blood or yellow fluid coming out of the nipple. Sometimes the nipple looks flat or inverted. It also might burn or itch. […] Paget disease usually affects only one breast. In 80-90% of cases, its usually found along with either ductal carcinoma in situ (DCIS) or infiltrating ductal carcinoma (invasive breast cancer). […] If no lump is felt in the breast tissue, and your biopsy results show the cancer has not spread within the breast tissue, the outlook (prognosis) is excellent. […] If the cancer has spread within the breast tissue (is invasive), the outlook is not as good, and the cancer will be staged and treated like any other invasive ductal carcinoma.

• #15 Mammary Paget’s Disease: An Update

  https://www.mdpi.com/2072-6694/14/10/2422

  Mammary Paget’s Disease is a non-invasive cutaneous malignancy of the breast involving the nipple-areolar complex that is commonly mistaken for benign breast conditions, leading to delay in diagnosis. […] Initially, MPD develops insidiously, gradually evolving over months to years as it extends from the nipple into the areola in a centrifugal growth pattern. Typically, MPD presents clinically as a unilateral rash of the nipple and areola that in more advanced cases may also involve the periareolar skin. […] In 98% (217) of the patients, the main presenting symptom was eczema or ulceration of the nipple. […] MPD-associated skin surface changes slowly progress, producing a dermatitictous appearance affecting the nipple, areola, and eventually the skin of the breast. […] Commonly, MPD is initially misdiagnosed as eczema, dermatitis, or psoriasis, which accounts for the frequent delay in diagnosis. […] Without treatment, the skin lesions and underlying disease will progress to the development of invasive breast cancer, potentially followed by lymph node and visceral metastasis.

• #16 Mammary Paget’s Disease: An Update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9139704/

  Mammary Pagets disease of the breast is an uncommon and often misdiagnosed breast malignancy. […] This review article discusses Pagets disease etiology, clinical presentation, differential diagnosis, diagnostic work-up, natural history and prognosis. […] Mammary Pagets disease is reported in 13% of all primary breast cancers. […] Between 93-100% of MPD cases are associated with underlying breast cancer, commonly central and multifocal tumors, mainly located near the areola. […] More than 90% of cases are associated with underlying DCIS or invasive ductal carcinoma (IDC). […] Initially, MPD develops insidiously, gradually evolving over months to years as it extends from the nipple into the areola in a centrifugal growth pattern. […] Typically, MPD presents clinically as a unilateral rash of the nipple and areola that in more advanced cases may also involve the periareolar skin.

• #17

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/pagets-disease-breast

  How fast Paget’s disease of the breast occurs varies per person. In some cases, it can develop slowly over several months or even years. For others, it may progress more rapidly, particularly if there’s an underlying invasive breast cancer. […] The initial skin changes might seem minor and easily overlooked, which is why many people don’t seek medical advice until the condition has advanced. Regular breast self-exams and being aware of any changes in your breast skin and nipple can help in catching the disease early.

• #18 Paget’s Disease of the Breast: Stages, Symptoms & Prognosis

  https://my.clevelandclinic.org/health/diseases/17913-pagets-disease-of-the-breast

  That depends on whether or not you have underlying ductal carcinoma, and what stage its in. If you only have cancer in your milk ducts and it hasnt spread to the surrounding breast tissues, its called ductal carcinoma in situ (DCIS). This is considered stage 0. This type of cancer is treated with surgical removal of the tumor(s) and nipple, followed by radiation. […] When ductal carcinoma does spread beyond the milk ducts, its called infiltrating or invasive ductal carcinoma. This cancer progresses in stages. In the early stages, you can still treat it by removing the affected breast tissue and axillary lymph nodes. Invasive breast cancer becomes more aggressive and difficult to treat in the later stages when it spreads beyond the breast. […] Breast cancer survival is based on the stage of the cancer when its detected. If you only have Paget’s disease of the nipple or ductal carcinoma in situ (stage 0) that hasnt spread beyond the milk ducts, your prognosis is excellent. Most people who discover and treat these conditions early will make a full recovery. Once breast cancer begins to spread, it becomes progressively harder to beat.

• #19 What Is Paget’s Disease of the Breast | Breast Care Center Miami

  https://www.toplinemd.com/breast-care-center-of-miami/blog/what-is-pagets-disease-of-the-breast/

  A common question regarding this condition is: How quickly does Paget’s disease of the breast progress? The progression can vary greatly from person to person. In some cases, it can develop slowly over months or even years, while in others, it may progress more rapidly. Regular breast exams and consultations with healthcare providers are crucial for monitoring any changes or developments. […] The prognosis for Paget’s disease of the breast largely depends on whether the underlying cancer is in situ or invasive and how early the cancer is detected and treated. Generally, the prognosis is better for cases where no lump is present in the breast and if the cancer has not spread.

• #20 Paget’s disease of the breast: Causes, symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/192362

  According to the American Cancer Society, Pagets disease usually appears in one breast or nipple. […] Cancer Research UK indicates that about half of all people with Pagets disease of the breast also have a breast lump behind the nipple. This usually means that a person has invasive breast cancer. […] When Pagets disease is a result of more advanced or aggressive cancers, especially invasive ductal carcinoma, there is a higher mortality rate. […] The factor that plays the most significant role in determining the outcome is early diagnosis. By the time there is a large mass or the cancer has spread to lymph nodes, the disease is more advanced and has a worse prognosis. […] Pagets disease of the breast is not usually an aggressive breast cancer. However, it can spread if a person does not seek prompt treatment. […] With early diagnosis and treatment, Pagets disease of the breast is typically curable.

• #21 Mammary Paget’s Disease: An Update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9139704/

  Without treatment, the skin lesions and underlying disease will progress to the development of invasive breast cancer, potentially followed by lymph node and visceral metastasis. […] The presence of a palpable breast tumor, lymph node enlargement, high nuclear grade, and age below 60 years are unfavorable prognostic factors that correlate with a high risk of invasive carcinoma and a high rate of lymph node metastasis.

• #22 Paget’s disease of the breast | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/types-of-breast-cancer/pagets-disease-of-the-breast

  Pagets disease of the breast is an uncommon type of breast cancer. […] The most common symptom of Pagets disease is a red, scaly rash on your nipple. Redness may be harder to see if you have black or brown skin. […] The rash can feel itchy, or you may have a burning sensation. The rash may spread to the darker area of skin around the nipple (areola). […] Other symptoms can include: The nipple becoming pulled in (inverted), Liquid (discharge) coming from the nipple, A lump behind the nipple. […] Most people with Pagets disease will have an early form of breast cancer called ductal carcinoma in situ (DCIS) under the nipple or elsewhere in the breast. […] Some people with Pagets disease will also have an underlying invasive breast cancer. […] Invasive breast cancer has the potential to spread from the breast to other parts of the body. […] Even if theres no lump, its still possible to have an invasive cancer.

• #23

  https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/

  Paget’s disease of the nipple, also known as Paget’s disease of the breast, is a rare condition associated with breast cancer. […] It causes eczema-like changes to the skin of the nipple and the area of darker skin surrounding the nipple (areola). It’s usually a sign of breast cancer in the tissue behind the nipple. […] Paget’s disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. […] The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated. […] Around half of all women diagnosed with Paget’s disease of the nipple have a lump behind the nipple. In 9 out of 10 cases this is an invasive breast cancer. […] Invasive cancer is where cancerous cells invade the surrounding breast tissue. Some women with Paget’s disease have invasive breast cancer but do not have a lump.

• #24 What You Should Know About Paget’s Disease of the Breast – Iowa Radiology

  https://www.iowaradiology.com/what-you-should-know-about-pagets-disease-of-the-breast/

  Symptoms can appear and disappear at first but tend to become more severe over time. […] If you notice these symptoms even if they come and go consider being evaluated by a breast specialist. […] Scaly or thickened skin around the nipple and areola […] Pain, burning, itching, tingling, or increased sensitivity in the nipple […] Nipple inversion or flattening […] Bloody or yellowish discharge. […] When no palpable tumor is present at the time of diagnosis, more than 9 out of 10 patients survive at least five years and more than 8 out of 10 survive at least ten years. […] If invasive cancer is found, it will be staged and treated accordingly.

• #25

  https://111.wales.nhs.uk/encyclopaedia/p/article/pagetsdiseaseofthenipple/

  However, most women with Paget’s disease who do not have a lump have non-invasive cancer. […] Paget’s disease of the nipple is usually associated with breast cancer. […] It’s treated by removing the cancerous part of the breast, or sometimes the entire breast using a procedure called a mastectomy. […] If Paget’s disease is detected and treated in its early stages, there’s a good chance of a full recovery.

• #26 What Is Paget’s Disease of the Nipple? – Iowa Radiology

  https://www.iowaradiology.com/what-is-pagets-disease-of-the-nipple/

  Pagets disease may cause the following symptoms: Flaky, crusty, red, or thickened skin around the nipple or areola […] Burning, tingling, or itching […] Pain or heightened sensitivity […] Flattened or inverted nipple […] Yellowish or bloody nipple discharge. Because Pagets disease is relatively rare, some symptoms are often mistaken for symptoms of more common skin ailments like eczema or dermatitis. The prognosis for Pagets disease patients depends largely on whether an additional palpable breast tumor is present. Among patients with no palpable tumor prior to surgery, the survival rate is very highreported at 9294% at 5 years and 8291% at 10 years. The presence identifiable underlying tumors has a significant impact on prognosis, however, with patients surviving five years at a rate of 3840% and 2233% surviving 10 years. As with any type of breast cancer, early detection, prompt treatment, and healthy habits are the keys to having the best possible chance of long-term survival.

• #27 Paget’s Disease of the Breast: Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/breast-cancer/guide/paget-disease/

  Many people with Pagets disease of the breast will go several months before theyre finally diagnosed. […] If Pagets disease hasnt spread to the surrounding breast tissue, the prognosis is excellent. According to the NCIs Surveillance, Epidemiology, and Ends Results (SEER) program, the overall five-year survival rate for women with Pagets was 82.6 percent. The five-year survival rate tends to decrease as the stage of the cancer increases; for women with stage 1 Pagets disease, the survival rate is 95.8 percent; stage 2 is 77.7 percent; stage 3 is 46.3 percent; stage 4 is 14.3 percent.

• #28 What You Should Know About Paget’s Disease Of The Breast

  https://www.healthdigest.com/958231/what-you-should-know-about-pagets-disease-of-the-breast/

  The NCI explains there are a number of factors involved in the prognosis and outcome, including if tumors are present in both breasts, just one, or neither; if the tumors are in situ or invasive; the stage of cancer; and if the cancer has spread to lymph nodes. […] Additionally, the NCI clarifies when Paget’s disease of the breast is combined with invasive breast cancer in the same breast, the five-year survival rate decreases with advanced stages of cancer (stage 1 being the least invasive with the highest survival rate and stage 4 the most invasive with the lowest survival rate).

• #29 Paget’s Disease of the Breast: Symptoms, Treatment, Survival

  https://www.verywellhealth.com/pagets-disease-of-the-breast-430628

  With Paget’s disease of the breast, the relative five-year survival is 87.1%. What this means is that 87 of every 100 people treated for Paget’s disease will live for at least five years. Some go on to live many years more and even have normal life expectancies. […] The five-year survival rate for Paget’s disease also varies by the stage of cancer. This is described by the National Cancer Institute as follows: Stage 1: 98.8%, Stage 2: 77.7%, Stage 3: 46.3%, Stage 4: 14.3%.

• #30 Mammary Paget’s Disease of the Nipple: Relatively Common but Still Unknown to Many

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6669392/

  Mammary Pagets disease is clinically defined as skin inflammation of the nipple area and is an adenocarcinoma of the epidermis of the nipple. […] The skin lesions progress slowly over months as scaly, fissured, or oozing erythema of the nipple and areola. Advanced lesions may appear as well-demarcated, eczema-like plaques with a pink or red hue. […] In the early stages, patients often present with nipple itchiness. […] The disease starts from the nipple area and gradually extends to the areola and to the surrounding skin in more advanced cases. The lesions appear eczematoid, erythematous, thickened, moist, or crusted with irregular borders, with or without fine scaling, induration, infiltration, secretion, bleeding, ulceration, and nipple invagination. […] Due to the wide range of presentation of this disease, it is common for patients presenting with these features to be misdiagnosed and to be treated for eczema, psoriasis, melanoma, infection, or trauma.

• #31 What were your Pagets symptoms? — Community Discussion Forums

  https://community.breastcancer.org/en/discussion/869894/what-were-your-pagets-symptoms

  Just searching for advice- Ive been worrying about Pagets for a few months but primary care doctor and OB does not seem to believe anything is wrong. It started last August when my left nipple was scabbing- it was yellow/whitish tinge and wouldnt actively discharge but when I looked at my nipple it just looked like a little scab. […] There was never any itching, no bleeding, just a continuous cycle of peeling. The only other symptom I noticed was that my left nipple always seemed harder or more erect than the right. […] My Paget’s started with some light crusting at the center of the nip – almost like dry skin cells. I’d scrape them away. Then I noticed a little injury to the side with oozing (I thought I must have scraped it on my watch or something). […] The skin was pink-to-reddish, had a distinctive edge. […] Itchiness, pin-prick sensations, pink/red skin with defined borders, and nip receeding more were my main clues. […] I notice my nipple was red ,rash and scabbing few years back but I did nt take it serious. […] I heard paget cancer is very easy to miss diagnost by the Dr.

• #32 Paget’s disease of the nipple | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/pagets-disease-of-the-nipple/

  Pagets disease usually affects the skin of one nipple and produces eczema-like symptoms, appearing as an itchy, red rash on the nipple that can extend to the darker area of surrounding skin (the areola). […] It can also appear as a small ulcer or dry, red, flaky patches of skin similar to psoriasis. […] Other possible symptoms include: itchiness or a burning sensation alongside visible changes to the nipple, bleeding from the skin of the nipple. […] If you’re experiencing itchiness, burning or bleeding but the nipple looks normal and isn’t red, dry or scaly this is extremely unlikely to be Pagets disease but should still be checked by a doctor. […] Pagets disease is usually a sign of breast cancer in tissue behind the nipple, or breast tissue away from the nipple. […] In about half of all cases of Pagets disease of the nipple, a lump is found in the breast. The majority of people with a lump will have invasive breast cancer, although this does not necessarily mean it has spread.

• #33

  https://www.nhs.uk/conditions/pagets-disease-nipple/diagnosis/

  As Paget’s disease of the nipple is usually a sign of breast cancer, it’s very important you see your GP if you notice changes to the tissue or skin of your breast. […] Paget’s disease is a form of breast cancer and the sooner it’s diagnosed, the better the outcome is likely to be. […] A skin biopsy is often used to confirm a diagnosis of Paget’s disease of the nipple. A small tissue sample will be taken from your nipple or the skin around it. The sample will be examined under a microscope and tested to see if it’s cancerous.

• #34 Difference Between Paget Disease and Eczema: Symptoms, Pictures, More

  https://www.healthline.com/health/womens-health/difference-between-pagets-disease-and-eczema

  Paget disease of the breast starts in the nipple and then spreads to the areola and breast skin. About 1 in 2 people with Paget disease of the breast have a lump behind the nipple. […] Symptoms of Paget disease are described below: Initial symptoms red, scaly rash on the nipple and areola flattened or retracted nipple small bumps on the nipple and sometimes the areola ulcerated nipple sore, inflamed skin bleeding from the nipple itching pain tingling or burning sensation nipple discharge. […] Early symptoms of Paget disease of the breast commonly include a red, scaly rash on the nipple and the circular area around it. This may look like eczema. […] Paget disease of the breast may look like eczema. Its important to see a doctor if you experience a dry, scaly rash on your nipple or a lump in your breast. Early diagnosis and treatment could help reduce the risk of complications.

• #35 Mammary Paget’s Disease of the Nipple: Relatively Common but Still Unknown to Many

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6669392/

  Mammary Pagets disease should be one of the diseases suspected in cases of persistent eczematous involvement of the nipple that remain non-responsive to topical treatment. The prognosis of mammary Pagets disease depends on the presence or absence of an underlying carcinoma and the stage of the disease.

• #36 Mammary Paget disease. Paget disease of the nipple

  https://dermnetnz.org/topics/mammary-paget-disease

  Despite the visible lesion, a delay in presentation or diagnosis is common. On average, diagnosis is made 12 months after onset in women and 89 months in men. Prognosis is therefore not as good as for more common forms of breast cancer. It is particularly poor for males, with a 2030% five-year survival.

• #37 What is Paget Disease of the Breast? | Dana-Farber Cancer Institute

  https://blog.dana-farber.org/insight/2021/04/what-is-paget-disease-of-the-breast/

  Paget disease of the breast occurs when cancer cells within the breast grow along the sides of the milk ducts and exit onto the skin of the nipple and surrounding circle of skin called the areola. It can arise at any age associated with breast cancer and usually involves a single breast. […] The most common symptoms of Paget disease of the breast are: […] Irritation of the skin of the nipple and areola; […] Inflammation and oozing known as an ulceration of the nipple and areola, especially if the ulceration doesn’t heal; […] Itching, tingling, or redness in the area. […] When the cancer underlying Paget disease of the breast is diagnosed at an early stage, as it commonly is, treatment is usually very effective, with about 90% of patients being cured. When the disease has had a chance to progress beyond this stage, success rates of treatment decline, underscoring the importance of having changes in the nipple examined by a physician at an early stage.

• #38 Paget’s Disease of the Breast | Baptist Health

  https://www.baptisthealth.com/care-services/conditions-treatments/pagets-disease-of-the-breast

  Pagets disease of the breast is a rare type of breast cancer found in the skin of the nipple or on the areola (dark circle of skin around the nipple). […] Many women who are diagnosed with Pagets disease of the breast will have a lump behind the nipple and the majority of those cases are invasive breast cancer. […] Symptoms may include: Nipple itching, Nipple burning, Dry, flaking or scaling skin of the nipple or areola, Skin rash that may be raised, red, crusting, oozing (resembles weeping eczema), raw, or bleeding, Bloody or pus-like nipple discharge, Inflammation and soreness, Flat or inverted nipple, Noticeable breast lump under the skin. […] Initially, symptoms may fluctuate but worsen over time. […] If Pagets disease of the breast is caught in its early stages, the prognosis for a full recovery is more likely.

• #39 Paget’s Disease of the Breast, A Rare Form of Cancer

  https://blog.uvahealth.com/2018/11/13/pagets-disease-of-the-breast/

  Pagets disease of the breast is a rare form of breast cancer, with symptoms that may resemble those caused by other medical conditions. […] While this type of cancer is rare, its also a red flag for ductal carcinoma in situ (DCIS) or other forms of invasive breast cancer. […] Its extremely important to recognize the symptoms of this disease so treatment can begin promptly. […] Pagets disease of the nipple causes symptoms that resemble those caused by other medical conditions. […] In many cases, this rare form of cancer initially looks like certain skin diseases, such as eczema and dermatitis. […] You should watch out for skin changes around your nipple and areola, including: Flaking, thickened or crusty skin around the nipple, Redness, itching or tingling around the nipple or areola, Pain or sensitivity around the nipple or areola, Nipple discharge that may be yellow-colored or bloody, One flattened nipple. […] Unfortunately, because mammary Pagets disease resembles other skin conditions, it may be misdiagnosed initially. […] Even though mammary Pagets disease is rare, its still important to be aware of any nipple or areola changes to help prevent complications from occurring.

• #40

  https://www.aurorahealthcare.org/services/cancer/breast-cancer/pagets-disease-breast

  Pagets disease of the breast typically signals that there might be underlying breast cancer, either in the ducts of the breast (ductal carcinoma in situ) or invasive breast cancer. […] Recognizing the symptoms of Paget’s disease of the breast is key to seeking timely treatment. […] The common signs you should be aware of: Nipple and areola changes: You might notice redness, flakiness or crustiness of the skin on your nipple and areola. These changes can look like eczema but don’t improve with typical treatments for skin conditions. Nipple discharge: There can be a yellowish or bloody discharge from your nipple. Itching or tingling: A persistent itching or tingling sensation in your nipple and areola area is another possible sign. Nipple inversion: Your nipple might become flattened or turned inward. Lump or thickening: Sometimes, there can be a palpable lump in your breast, indicating an underlying mass.

• #41 Paget’s disease of the breast – Vejthani Hospital | JCI Accredited International Hospital in Bangkok, Thailand.

  https://www.vejthani.com/diseases-conditions/pagets-disease-of-the-breast/

  Usually, signs and symptoms of this condition are only present in one breast, starting in the nipple and potentially spreading to other parts of the breast. Skin changes may appear and disappear early on or improve with topical treatment, leading to the illusion of healing. Typically, signs and symptoms persist for several months before a diagnosis is confirmed. […] It is important to monitor any changes in your breasts. If you detect a lump or experience persistent itching or skin irritation for over a month, schedule an appointment with your doctor. Additionally, if treatment for a breast injury does not resolve the issue, schedule a follow-up appointment with your doctor.

• #42 Pagets Disease | St Marks – Breast Centre of Excellence

  https://smwh.co.nz/breast-cancer/breast-cancer-types/pagets-disease/

  The symptoms usually affect the nipple and then spread to the areola and then the breast. It is common that the symptoms disappear for a while and this may be tricky as the patient takes it as a sign that the disease has cured, which is not true. […] If you notice skin irritation on the breast that does not seem to heal for over a month, seek the opinion of a specialist as to whether you have Pagets disease.

• #43 Inflammatory Breast Cancer Houston | Paget’s Disease of the Nipple

  https://pinkdoorimaging.com/breast-symptoms-may-result-breast-cancer-skin-changes-nipple-inflammation/

  A diagnostic mammogram and an ultrasound will often find the underlying breast cancer. Skin biopsy will provide a definitive diagnosis by identifying cancer cells in the skin. A diagnostic mammogram and ultrasound may reveal additional tumors. The type of treatment will be dependent on findings of additional tumors and or involvement of the lymph nodes. Occasionally, Pagets disease of the nipple may be confined to the nipple without an underlying tumor in the breast.

• #44 logo–sylvester

  https://umiamihealth.org/en/sylvester-comprehensive-cancer-center/treatments-and-services/breast-cancer/paget%E2%80%99s-disease-of-the-nipple-

  Paget’s disease is a rare cancer of the nipple and areola, the darker skin around the nipple. It affects both men and women. […] The signs and symptoms of Paget’s disease include irritation around the nipple, flaky or crusty skin, itching of the skin, and nipple discharge. Most patients with Paget’s disease also have an underlying breast cancer within the breast. Therefore, if you develop these signs/symptoms, it is important to see your doctor for breast imaging and a possible biopsy of the skin.

• #45 Paget Disease of the Breast – NCI

  https://www.cancer.gov/types/breast/paget-breast-fact-sheet

  The symptoms of Paget disease of the breast are often mistaken for those of some benign skin conditions, such as dermatitis or eczema. These symptoms may include the following: […] Because the early symptoms of Paget disease of the breast may suggest a benign skin condition, and because the disease is rare, it may be misdiagnosed at first. People with Paget disease of the breast have often had symptoms for several months before being correctly diagnosed. […] The prognosis, or outlook, for people with Paget disease of the breast depends on a variety of factors, including the following: […] The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival.

• #46 Difference Between Paget Disease and Eczema: Symptoms, Pictures, More

  https://www.healthline.com/health/womens-health/difference-between-pagets-disease-and-eczema

  Some factors that can affect the outlook for people with Paget disease of the breast are: whether theres a tumor under the nipple or elsewhere in the breast whether the tumor is non-invasive or invasive whether the cancer has reached the lymph nodes tumor grade and stage hormone receptor and HER2 status. […] DCIS is an early form of breast cancer that hasnt spread outside the breast ducts. With treatment, the outlook is good. Without treatment, DCIS can become invasive. The survival rate may be lower for invasive breast cancer that has spread to breast tissue or the lymph nodes.

• #47

  https://myhealth.alberta.ca/Health/aftercareinformation/pages/conditions.aspx?hwid=uh4323

  Paget disease of the breast is a type of cancer. Breast cancer is the abnormal growth of cells in the breast. In Paget disease of the breast, some people notice a change in the skin of their nipple and the area around the nipple (areola). The skin can be reddish and scaly. Other people don’t notice any skin changes but do have pain, burning, or itching on their nipple. […] Watch closely for changes in your health, and be sure to contact your doctor or nurse advice line if you have any symptoms that the cancer has come back or spread. These symptoms include: New lumps. Bone pain. Chest pain. Shortness of breath. Belly pain. Headaches that don’t go away.

• #48 Paget Disease of the Breast: Care Instructions | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.paget-disease-of-the-breast-care-instructions.uh4323

  Paget disease of the breast is a type of cancer. In Paget disease of the breast, some people notice a change in the skin of their nipple and the area around the nipple (areola). The skin can be reddish and scaly. Other people don’t notice any skin changes but do have pain, burning, or itching on their nipple. […] Watch closely for changes in your health, and be sure to contact your doctor if you have any symptoms that the cancer has come back or spread. These symptoms include: New lumps. Bone pain. Chest pain. Shortness of breath. Belly pain. Headaches that don’t go away.

• #49 Paget’s Disease of the Nipple | Magee-Women’s Hospital

  https://www.upmc.com/locations/hospitals/magee/services/magee-womens-cancers/breast-cancer-program/types-of-breast-cancer/pagets-disease

  Your recovery from Paget’s disease of the nipple will depend on the type of treatment you received. It usually takes several months to recover from surgery. It can take months to recover from chemotherapy and radiation, too. These treatments may make you tired and weak and cause side effects like nerve damage and swelling (lymphedema).

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