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• #1 Mayo Clinic Health Library – Nickel allergy | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20157225

  Nickel allergy is a common cause of allergic contact dermatitis an itchy rash that appears where your skin touches a usually harmless substance. […] The exact cause of nickel allergy is unknown. As with other allergies, nickel allergy develops when your immune system views nickel as a harmful, rather than harmless substance. […] Your immune system’s sensitivity to nickel may develop after your first exposure or after repeated or prolonged exposure.

• #2 Nickel Allergy: Rash, Symptoms, Testing, Treatment & Prevention

  https://my.clevelandclinic.org/health/diseases/17842-nickel-allergy

  Nickel allergy is a skin rash or irritation that occurs when you come into contact with nickel. This condition is a form of allergic contact dermatitis. […] Researchers dont know the exact cause of nickel allergy. It happens when your immune system sees nickel as harmful. […] A nickel allergy may develop the first time youre exposed to nickel or after many times. Once your body has a first allergic reaction to nickel, youll likely continue to be allergic every time youre in contact with it.

• #3 Nickel allergy

  https://www.mymlc.com/health-information/diseases-and-conditions/n/nickel-allergy/

  Nickel allergy is a common cause of allergic contact dermatitis — an itchy rash that appears where your skin touches a usually harmless substance. […] The exact cause of nickel allergy is unknown. As with other allergies, nickel allergy develops when your immune system views nickel as a harmful, rather than harmless substance. […] Once your body has developed a reaction to a particular agent (allergen) — in this case, nickel — your immune system will always be sensitive to it. That means anytime you come into contact with nickel, your immune system will respond and produce an allergic response. […] Your immune system’s sensitivity to nickel may develop after your first exposure or after repeated or prolonged exposure.

• #4 Nickel Allergy – ECARF

  https://www.ecarf.org/en/information-portal/allergies-overview/nickel-allergy/

  Nickel allergy is a contact allergy (also referred to as type IV or delayed type hypersensitivity). […] This delay is caused by what are called helper T cells (medical term: T-lymphocytes). […] In a contact allergy, the helper T cells remember a presumably harmless substance like nickel. […] Nickel is the most common contact allergen in the world. […] True symptoms in the form of allergic eczema triggered by nickel or other substances develop in 8.0% of German adults over the course of their lifetime. […] Nickel is virtually everywhere. […] Since the 1970s, jeans buttons, costume jewellery and piercing jewellery have been the main offenders. […] An important step in the diagnostic procedure is the patient history. […] A patch test is used to diagnose a contact allergy. […] The most effective method for relieving symptoms is to avoid the allergy-triggering substance. […] In rare cases, the nickel content in food can exacerbate eczema in patients with a severe nickel allergy.

• #5 Nickel Allergy – Causes, Symptoms and Treatment

  https://www.iafaforallergy.com/allergies-a-to-z/nickel-allergy/

  Nickel allergy is a type of contact dermatitis caused by direct contact with nickel. […] This type of allergy manifests when the immune system views nickel as an allergen or a harmful substance. Under normal circumstances, the immune system safeguards the body against harmful pathogens like bacteria, viruses, and even toxic substances. The immune system can develop sensitivity towards nickel on first exposure and can also develop on subsequent exposures. […] Nickel is a metal that is often responsible for allergic contact dermatitis which appears on the skin. Nickel allergy is linked with different ornaments such as earrings and dental implants that often have this metal in it. The allergic reaction usually appears on repeated and prolonged exposure to things that have nickel in them. If you are allergic to the metal, it is best advised to limit the exposure as you will always be sensitive towards the metal.

• #6 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy results in a skin response after the skin comes in contact with an item that releases a large amount of nickel from its surface. […] The pathophysiology is divided into induction elicitation phases. Induction is the critical phase (immunological event) when skin contact to nickel results in antigen presentation to the T cells, and T cell duplication (cloning) occurs. […] The metal cation Ni++ is a low molecular weight hapten that easily penetrates the stratum corneum (top layer of skin). […] The complex is predominantly expressed on major histocompatibility complex (MHC) II, which activates and clonally expands naive CD4+ T cells. […] The pathophysiology of systemic nickel allergy syndrome (SNAS) is not well understood.

• #7 What causes metal allergies? | Live Science

  https://www.livescience.com/health/allergies/what-causes-metal-allergies

  The nickel ions latch on to specific proteins present in the skin. And because these metal-protein complexes are perceived by the body as „foreign,” they trigger an immune response, according to the medical resource StatPearls. […] Through prolonged and repeated exposure to a metal, immune cells can become sensitized to it in this way but it’s not fully understood why some people experience this sensitization while others don’t. The American Academy of Pediatrics (AAP) notes that genetic factors related to the immune system and to skin’s outer barrier likely play a role. Environmental factors, such as whether you regularly work with potentially allergy-triggering metals, may also raise the risk, Mayo Clinic says. […] People with metal allergies can also develop systemic contact dermatitis, which occurs when metal particles reach the skin from the bloodstream, as can occur when these particles are ingested with food or medication.

• #8 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy results in a skin response after the skin comes in contact with an item that releases a large amount of nickel from its surface. […] The pathophysiology is divided into induction elicitation phases. Induction is the critical phase (immunological event) when skin contact to nickel results in antigen presentation to the T cells, and T cell duplication (cloning) occurs. […] The metal cation Ni++ is a low molecular weight hapten that easily penetrates the stratum corneum (top layer of skin). […] The complex is predominantly expressed on major histocompatibility complex (MHC) II, which activates and clonally expands naive CD4+ T cells. […] The pathophysiology of systemic nickel allergy syndrome (SNAS) is not well understood.

• #9 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy results in a skin response after the skin comes in contact with an item that releases a large amount of nickel from its surface. […] The pathophysiology is divided into induction elicitation phases. Induction is the critical phase (immunological event) when skin contact to nickel results in antigen presentation to the T cells, and T cell duplication (cloning) occurs. […] The metal cation Ni++ is a low molecular weight hapten that easily penetrates the stratum corneum (top layer of skin). […] The complex is predominantly expressed on major histocompatibility complex (MHC) II, which activates and clonally expands naive CD4+ T cells. […] The pathophysiology of systemic nickel allergy syndrome (SNAS) is not well understood.

• #10 Molecular Mechanisms of Nickel Allergy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4783936/

  Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. […] A previous study indicated that nickel (II) sulfate has the highest sensitization rate and affects approximately 15% of the population, followed by cobalt chloride and potassium dichromate, which approximately 5% and 3% of the population, respectively. Nickel allergy is the most common, and clinically important condition that is becoming a threat to public health. […] Nickel ions released from various alloys are potent allergens or haptens that can trigger skin inflammation. They penetrate the skin and activate epithelial cells that produce various cytokines or chemokines. […] Human toll-like receptor (TLR) 4 has been shown to play a crucial role in the development of contact allergy to nickel.

• #11 Why Are So Many People Allergic to Nickel? | Technology Networks

  https://www.technologynetworks.com/immunology/news/why-are-so-many-people-allergic-to-nickel-339206

  The metal nickel is one of the most common triggers of allergic contact dermatitis in humans. This skin inflammation results from a gradual immune reaction in allergic people, e.g. if the skin repeatedly comes into contact with nickel-containing jewelry, piercings or jeans buttons. […] The cause of the allergic reaction are T lymphocytes (T cells). These cells are part of the body’s defenses and normally react to viruses or bacteria in the skin. In the case of a nickel allergy, they also respond to electrically charged nickel atoms (ions) that can be released from nickel containing products. […] The BfR researchers discovered peculiarities in human receptors that react to nickel ions. About 43 percent of the corresponding T cells have the amino acid histidine in the specific identification part of the docking site (i.e. the variable subunit of the receptor). This amino acid can bind to nickel ions. […] These findings are an important indicator of how the human immune system identifies nickel ions and potentially represents an explanation for why people suffer from nickel allergy so often.

• #12 Nickel allergy – Stormont Vail HealthStormont Vail Health

  https://www.stormontvail.org/mc-content/nickel-allergy/

  Your immune system’s sensitivity to nickel may develop after your first exposure or after repeated or prolonged exposure. […] Certain factors may increase your risk of developing nickel allergy, including having ear or body piercings. […] If you work in an occupation that constantly exposes you to nickel, your risk of developing an allergy may be higher than it is for someone who doesn’t work with the metal. […] In addition, people who have regular exposure to nickel while doing “wet work” — as a result of either sweat or frequent contact with water — may be more likely to develop nickel allergy. […] Other people who may have an increased risk of nickel allergy include metalworkers, tailors and hairdressers. […] Females are more likely to have a nickel allergy than are males. […] You may have inherited a tendency to develop a nickel allergy if other people in your family are sensitive to nickel. […] People who have a sensitivity to other metals may also be allergic to nickel.

• #13 Nickel allergy – Knowledge and References – Taylor & Francis

  https://taylorandfrancis.com/knowledge/Engineering_and_technology/Biomedical_engineering/Nickel_allergy/

  Nickel allergy is a condition where prolonged and direct contact with nickel-containing items causes the immune system to become sensitized to nickel ions, leading to allergic contact dermatitis (ACD) characterized by symptoms such as rash, itch, redness, or dry skin. […] Nickel is the most common contact allergen, with 15–20% of women suffering from nickel allergy; a frequency 3–10 times higher than in men. […] Nickel released from decorative electroplated articles can cause ACD, appearing as a rash, itch, redness or dry skin in nickel-sensitised persons. […] Decorative nickel-containing articles may release nickel ions when in direct and prolonged contact with skin, causing the immune system to become nickel-sensitised if sufficient nickel ions are absorbed through the skin repeatedly in the same area. This can cause allergic contact dermatitis (ACD), appearing as a rash, itch, redness or dry skin in nickel-sensitised persons, often referred to as ‘Nickel Allergy’. […] Non-occupational sensitisation sometimes occurs when skin is in contact with nickel-plated haberdashery items such as clothing hooks, clasps and zippers, and may also arise from costume jewellery and body piercing.

• #14 Asthma Doctor | Causes, Symptoms and Treatments of a Nickel Allergy – National Allergy & ENT

  https://nationalallergyandent.com/asthma-doctor-causes-symptoms-and-treatments-of-a-nickel-allergy/

  A nickel allergy is caused when your skin has an allergic reaction to items that contain nickel. […] More than 18 percent of people living in North American have developed an allergic reaction to nickel. […] A nickel allergy can occur in both males and females but is ultimately more common in females. […] Nickel allergies cause some severe skin issues. Many people that suffer from nickel allergies have areas of their skin that become itchy, red and blistered. […] If you develop a nickel allergy you should first contact an allergy doctor. […] Once you figure out that you are allergic to nickel and you begin treatment, it can take two to four weeks for the symptoms to subside. […] They can test and make sure that your allergy is in fact nickel related.

• #15 Two Cents About Nickel Allergy

  https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/nickel

  Nickel is a leading cause of allergic contact dermatitisan itchy rash that develops when a persons skin touches a normally harmless material. […] Studies show that body piercing is the single most common cause of nickel allergy. […] Nickel is the most common metal that people are allergic to. […] Jewelry is a frequent trigger of nickel allergy. The only way to prevent a reaction is to avoid wearing metal with nickel in it.

• #16 RASH FROM NICKEL ALLERGY …Did… – Port St Lucie AllergistFacebookShared with Public

  https://www.facebook.com/PortStLucieAllergy/posts/rash-from-nickel-allergy-did-you-know-nickel-is-the-most-common-metal-allergy-ni/945978550252392/

  Nickel is the most common metal allergy; […] Nickel allergy causes a red itchy, bumpy rash. […] Nickel is a leading cause of allergic contact dermatitis–an itchy rash that develops when a person’s skin touches a normally harmless material. […] More women than men are allergic to nickel. This is probably because women are more likely to have pierced ears. […] Studies show that body piercing is the single most common cause of nickel allergy.

• #17 Nickel Allergy

  https://www.healthhub.sg/a-z/diseases-and-conditions/nickel_allergy_nsc

  Anybody can be allergic to nickel, but it usually begins in teenagers at the time they are beginning to wear cheap metal jewellery. […] Nickel sensitivity is common, especially in women, particularly after they have had their ears pierced. However, more men have piercings today, which is increasing the incidence of nickel allergy among males. It is also possible, but much less common, suddenly and without reason to suffer from nickel allergy later in life. […] It is not known why some people become allergic to nickel when others do not. But, people with jobs that require frequent contact with the metal such as hairdressing, nursing and catering, as well as jobs that require one to handle cash and metal are more likely to be sensitive to it. […] Once you become sensitive to nickel you are likely to remain so for life. But not everything containing nickel will necessarily bring out a rash every time. It is more likely to happen if your skin is raw or broken. Some women may find they are more sensitive to nickel on certain days of their menstrual cycle. In addition, your sensitivity to nickel may in time reduce to become less troublesome.

• #18 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy is any of several allergic conditions provoked by exposure to the chemical element nickel. […] Nickel exposure is common in many industries, and the performance of normal work tasks can result in nickel skin levels sufficient to elicit dermatitis. […] Historically, workplaces where prolonged contact with soluble nickel has been high have shown high risks for allergic contact nickel dermatitis. […] Nickel can also be present in food and drinking water; ingestion of increased nickel is not associated with systemic allergic disease, but is associated with flare-ups of dermatitis or aggravation of vesicular hand eczema. […] The risk of an object eliciting nickel allergy is linked to the amount of nickel released by its surface (and not to its total nickel content). […] The determining factor in sensitization is exposure of significant amounts of „free nickel”.

• #19 Metal Hypersensitivity – Causes, Symptoms, Treatment, Diagnosis – MedBroadcast.com

  https://medbroadcast.com/condition/getcondition/metal-hypersensitivity

  Metal hypersensitivity is a disorder of the immune system. It is estimated that up to 17% of women and 3% of men are allergic to nickel and that 1% to 3% of people are allergic to cobalt and chromium. […] The symptoms of metal hypersensitivity are caused when the body’s immune system starts to view metal ions as foreign threats. […] Nickel is one of the most frequent allergens, causing significant local contact dermatitis (skin reddening and itching). […] Aside from everyday items, medical devices also contain possible allergens such as chromium and titanium. […] In addition, people who already have an autoimmune disorder (a disorder where the immune system is overactive) can have a higher risk of a metal hypersensitivity, as their immune system is in a constant state of activity.

• #20 Walk-in Dermatology – What you Should Know about Silver and Nickel Allergies

  https://walkindermatology.com/what-you-should-know-about-silver-and-nickel-allergies/

  Most of the time, these skin allergies are actually nickel allergies. […] A nickel allergy occurs when the bodys immune system views the nickel ions as foreign threats. […] Metals such as nickel, cobalt, copper, and chromium are usually the culprits of these allergic reactions. […] Patients who have autoimmune disorders are at a higher risk for metal hypersensitivity, because their immune system is in a constant state of activity. You are also more likely to develop a nickel allergy if your family members are allergic as well. […] A nickel allergy often occurs after prolonged exposure and only in the area of the skin the nickel came into contact with. […] If you have a nickel allergy and want to take care of your skin, titanium is a popular choice. […] People with nickel allergies should ask about the jewelry they plan to buy.

• #21 Nickel Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK557638/

  Nickel allergy is a type of allergic contact dermatitis. A nickel allergy is commonly encountered with jewelry, kitchen tools, and silverware. In individuals who are sensitive to nickel, ingestions of certain foods (e.g., chocolate, nuts, oats, green beans, peas) may cause systemic nickel allergy syndrome (SNAS) or lead to chronic dermatitis. […] It is believed certain underlying inflammatory conditions (e.g., ulcerative colitis) can increase the likelihood of developing a nickel allergy. […] Nickel allergy is a type of contact dermatitis caused by direct contact with nickel. It is the most common identifiable cause of metal-related contact dermatitis and may be encountered in a variety of healthcare settings, from primary care clinics to emergency departments.

• #22 Nickel Allergy – MD Searchlight

  https://mdsearchlight.com/allergy/nickel-allergy/

  Allergic contact dermatitis (ACD) is a condition that develops when your skin is exposed repeatedly to something that irritates it or to which it is allergic. Its the most common skin condition people get from their jobs. This skin reaction is known as a delayed-hypersensitivity reaction, and it can be caused by contact with metals, especially nickel. […] A nickel allergy is a kind of skin allergy that happens upon contact with the metal. Its commonly seen with items like jewelry, kitchen utensils, and cutlery. For people who are sensitive to nickel, eating certain foods like chocolate, nuts, oats, green beans, and peas might cause a more severe reaction called systemic nickel allergy syndrome (SNAS) or lead to long-term skin inflammation. […] Theres a belief that having certain existing inflammation conditions, like ulcerative colitis (a type of bowel disease), can make a person more likely to develop a nickel allergy.

• #23 Nickel Allergy | New York Allergy and Sinus Centers

  https://www.nyallergy.com/nickel-allergy/

  A family history of nickel allergy, along with existing sensitivities to other metals, can further predispose individuals to this condition. […] Understanding which foods contain nickel is essential for maintaining overall health and preventing allergic reactions. […] There is evidence suggesting a genetic component to nickel allergy. Individuals with a family history of nickel sensitivity may be more likely to develop the allergy themselves. […] Systemic nickel allergy syndrome (SNAS) is a condition where individuals with allergic to nickel experience systemic symptoms upon exposure to nickel. Symptoms can include headaches, fatigue, gastrointestinal distress, and skin reactions.

• #24 Nickel Allergies Symptoms, Tests, and Treatment

  https://www.healthline.com/health/allergies/nickel

  A nickel allergy is the body’s adverse immune response when someone comes into contact with a product containing nickel. […] The immune system begins to produce chemicals to ward off the substance. The immune system of someone with a nickel allergy is reacting to the object or food containing nickel. That reaction leads to various symptoms, including rashes and itching. […] The exact cause of a nickel allergy isn’t known. However, researchers believe that the sensitivity to nickel may be genetic, that is, inherited from a relative.

• #25 Nickel allergy – how to detect it, how to protect against it

  https://www.allergybestbuys.co.uk/pages/nickel-allergy-how-to-detect-it-how-to-protect-against-it

  Nickel is a metal that’s used in a wide variety of products including jewellery, belt buckles and watch straps and is so widely used that nickel allergy is the most common form of allergic contact dermatitis in the developed world. […] Nickel allergy may occur at any time during a persons life, even when symptoms didnt appear in the past. A person may have become allergic after being exposed to a large amount of nickel or after a nickel-containing material came into contact with broken skin (such as a cut or sunburn). A persons tendency to react to nickel is probably genetic, meaning that nickel allergy probably runs in families.

• #26 Nickel allergy: Symptoms, treatment, and what to avoid

  https://www.medicalnewstoday.com/articles/321400

  A nickel allergy occurs when a person has an adverse reaction to a food or object containing nickel. […] The medical community is unsure why people develop allergies to nickel. […] An increasing number of people in the United States are allergic to nickel. […] The allergy can appear at any age. […] The only way to prevent an allergic reaction is to avoid contact with products containing nickel. […] There is no cure for an allergy to nickel. The best way to prevent a reaction is to avoid the allergen. […] A person with a nickel allergy will continue to be sensitive to the metal for the rest of their life.

• #27 Nickel Allergy

  https://www.healthhub.sg/a-z/diseases-and-conditions/nickel_allergy_nsc

  Anybody can be allergic to nickel, but it usually begins in teenagers at the time they are beginning to wear cheap metal jewellery. […] Nickel sensitivity is common, especially in women, particularly after they have had their ears pierced. However, more men have piercings today, which is increasing the incidence of nickel allergy among males. It is also possible, but much less common, suddenly and without reason to suffer from nickel allergy later in life. […] It is not known why some people become allergic to nickel when others do not. But, people with jobs that require frequent contact with the metal such as hairdressing, nursing and catering, as well as jobs that require one to handle cash and metal are more likely to be sensitive to it. […] Once you become sensitive to nickel you are likely to remain so for life. But not everything containing nickel will necessarily bring out a rash every time. It is more likely to happen if your skin is raw or broken. Some women may find they are more sensitive to nickel on certain days of their menstrual cycle. In addition, your sensitivity to nickel may in time reduce to become less troublesome.

• #28 Mayo Clinic Health Library – Nickel allergy | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20157225

  Nickel allergy is a common cause of allergic contact dermatitis an itchy rash that appears where your skin touches a usually harmless substance. […] The exact cause of nickel allergy is unknown. As with other allergies, nickel allergy develops when your immune system views nickel as a harmful, rather than harmless substance. […] Your immune system’s sensitivity to nickel may develop after your first exposure or after repeated or prolonged exposure.

• #29 Nickel allergy – Stormont Vail HealthStormont Vail Health

  https://www.stormontvail.org/mc-content/nickel-allergy/

  Your immune system’s sensitivity to nickel may develop after your first exposure or after repeated or prolonged exposure. […] Certain factors may increase your risk of developing nickel allergy, including having ear or body piercings. […] If you work in an occupation that constantly exposes you to nickel, your risk of developing an allergy may be higher than it is for someone who doesn’t work with the metal. […] In addition, people who have regular exposure to nickel while doing “wet work” — as a result of either sweat or frequent contact with water — may be more likely to develop nickel allergy. […] Other people who may have an increased risk of nickel allergy include metalworkers, tailors and hairdressers. […] Females are more likely to have a nickel allergy than are males. […] You may have inherited a tendency to develop a nickel allergy if other people in your family are sensitive to nickel. […] People who have a sensitivity to other metals may also be allergic to nickel.

• #30 Nickel Allergy: Rash, Symptoms, Testing, Treatment & Prevention

  https://my.clevelandclinic.org/health/diseases/17842-nickel-allergy

  Nickel allergy is a skin rash or irritation that occurs when you come into contact with nickel. This condition is a form of allergic contact dermatitis. […] Researchers dont know the exact cause of nickel allergy. It happens when your immune system sees nickel as harmful. […] A nickel allergy may develop the first time youre exposed to nickel or after many times. Once your body has a first allergic reaction to nickel, youll likely continue to be allergic every time youre in contact with it.

• #31 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy is any of several allergic conditions provoked by exposure to the chemical element nickel. […] Nickel exposure is common in many industries, and the performance of normal work tasks can result in nickel skin levels sufficient to elicit dermatitis. […] Historically, workplaces where prolonged contact with soluble nickel has been high have shown high risks for allergic contact nickel dermatitis. […] Nickel can also be present in food and drinking water; ingestion of increased nickel is not associated with systemic allergic disease, but is associated with flare-ups of dermatitis or aggravation of vesicular hand eczema. […] The risk of an object eliciting nickel allergy is linked to the amount of nickel released by its surface (and not to its total nickel content). […] The determining factor in sensitization is exposure of significant amounts of „free nickel”.

• #32 Molecular Mechanisms of Nickel Allergy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4783936/

  Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. […] A previous study indicated that nickel (II) sulfate has the highest sensitization rate and affects approximately 15% of the population, followed by cobalt chloride and potassium dichromate, which approximately 5% and 3% of the population, respectively. Nickel allergy is the most common, and clinically important condition that is becoming a threat to public health. […] Nickel ions released from various alloys are potent allergens or haptens that can trigger skin inflammation. They penetrate the skin and activate epithelial cells that produce various cytokines or chemokines. […] Human toll-like receptor (TLR) 4 has been shown to play a crucial role in the development of contact allergy to nickel.

• #33 Nickel Allergy: Genetics, causes, natural solutions

  https://www.geneticlifehacks.com/nickel-allergy-genes/

  Nickel allergy is a common cause of allergic contact dermatitis (rash). It is estimated that 8-20% of people are sensitive to nickel. […] While genetic susceptibility plays a role, nickel allergy is caused by exposure to nickel, often for a long period of time. […] Systemic symptoms of nickel allergy can include respiratory, gastrointestinal, and neurological symptoms from eating foods that contain nickel (or an implanted device that contains nickel). […] If you have a nickel allergy, you may also be sensitive to certain foods that contain nickel or other metals that cross-react with nickel. […] Nickel causes the cell to increase inflammation and oxidative stress. This can lead to cell death at higher levels.

• #34 Nickel (Jewelry) Allergies: Symptoms, Treatments, and Avoid Triggers

  https://www.webmd.com/allergies/nickel-jewelry-allergy

  If earrings make your earlobes itch or your necklace leaves a rash around your neck, you may be allergic to nickel. […] Its one of the most common skin allergies, in part because nickel is used in so many things, including jewelry, cell phones, coins, zippers, eyeglass frames, belt buckles, and keys. […] Your doctor can often diagnose a nickel allergy by looking at your skin and asking if youve touched anything metal. […] Once a nickel allergy develops, it often lasts your whole life. […] The most important thing you can do is avoid contact with objects that can cause a reaction. […] If your skin is cracked or blistered, you should take off any metal jewelry right away and see your doctor for treatment to avoid getting an infection. […] If you’re extremely sensitive to nickel, you may also need to avoid nickel-rich foods such as mixed nuts and chocolate.

• #35 Nickel allergy – Stormont Vail HealthStormont Vail Health

  https://www.stormontvail.org/mc-content/nickel-allergy/

  Nickel allergy is a common cause of allergic contact dermatitis — an itchy rash that appears where your skin touches a usually harmless substance. […] Nickel allergy is often associated with earrings and other jewelry. But nickel can be found in many everyday items, such as coins, zippers, eyeglass frames, cosmetics, detergents, and even some electronics, including cellphones and laptops. […] It may take repeated or prolonged exposure to items containing nickel to develop a nickel allergy. […] The exact cause of nickel allergy is unknown. As with other allergies, nickel allergy develops when your immune system views nickel as a harmful, rather than harmless substance. […] Once your body has developed a reaction to a particular agent (allergen) — in this case, nickel — your immune system will always be sensitive to it.

• #36 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Nickel-Allergy.aspx

  Nickel or nickel sulfate hexahydrate is a common allergen that causes contact dermatitis in sensitized individuals. […] Systemic responses can also result from dietary ingestion of nickel. […] Nickel ingestion through the diet in nickel-sensitive people triggers a series of changes in the immune system that can lead to the development of clinical reactions. […] The mechanism of absorption of ingested nickel in the body is not fully understood yet, though it has been proved that vitamin C and iron are capable of decreasing the absorption of dietary nickel.

• #37 Nickel Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK557638/

  Nickel allergy is a type of allergic contact dermatitis. A nickel allergy is commonly encountered with jewelry, kitchen tools, and silverware. In individuals who are sensitive to nickel, ingestions of certain foods (e.g., chocolate, nuts, oats, green beans, peas) may cause systemic nickel allergy syndrome (SNAS) or lead to chronic dermatitis. […] It is believed certain underlying inflammatory conditions (e.g., ulcerative colitis) can increase the likelihood of developing a nickel allergy. […] Nickel allergy is a type of contact dermatitis caused by direct contact with nickel. It is the most common identifiable cause of metal-related contact dermatitis and may be encountered in a variety of healthcare settings, from primary care clinics to emergency departments.

• #38 Nickel Allergy

  https://dermnetnz.org/topics/nickel-allergy

  Nickel allergy is one of the most common causes of contact allergic dermatitis. In affected individuals, dermatitis (also called eczema) develops in places where nickel-containing metal is touching the skin. […] Nickel allergy may develop at any age and in males and females. Once this nickel allergy has developed, it persists for many years, often life-long. […] It has been suggested that in nickel allergic people pompholyx may be due to nickel in the diet. […] Unfortunately, desensitization with injections or pills is not possible so the allergy tends to persist long-term. […] This diet low in nickel-containing foods has been suggested to patients with severe contact allergy to nickel. Its efficacy is unknown. Nickel cannot be completely avoided from diet.

• #39 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Nickel-Allergy.aspx

  Nickel or nickel sulfate hexahydrate is a common allergen that causes contact dermatitis in sensitized individuals. […] Systemic responses can also result from dietary ingestion of nickel. […] Nickel ingestion through the diet in nickel-sensitive people triggers a series of changes in the immune system that can lead to the development of clinical reactions. […] The mechanism of absorption of ingested nickel in the body is not fully understood yet, though it has been proved that vitamin C and iron are capable of decreasing the absorption of dietary nickel.

• #40 Nickel Allergy and Autoimmune Disease

  https://www.verywellhealth.com/nickel-allergy-and-autoimmune-disease-5198646

  A nickel allergy could make you more susceptible to autoimmune disease, according to research. Nickel allergy is sometimes called nickel allergic contact dermatitis (NACD). […] Nickel is the most common cause of metal allergies. And its being increasingly tied to several types of autoimmune disease. Researchers are looking into common underlying mechanisms to understand how the two may be related. […] Nickel allergy can be acquired anytime during your lifetime, unlike some allergies like food allergies that often occur very early in life. […] Your sweat and other bodily fluids can leach nickel from stainless steel and other alloys. Then your skin absorbs the metal. The allergy is often caused by direct and prolonged exposure to items that release a lot of nickel. Once youre sensitized to it, even small amounts of nickel exposure may be a problem.

• #41

  https://www.wyndly.com/blogs/learn/nickel-allergy-testing?srsltid=AfmBOoohmR0_azIc1ZcMXunkTWOibDdgXt2MUuYTguC5VObGZFsM7VNL

  Nickel allergies are more common among women and girls, primarily due to more frequent exposure from jewelry and other metal items. However, anyone can develop a nickel allergy at any age. […] Yes, a nickel allergy can affect areas of the body not directly in contact with the metal. Despite the common belief that nickel allergy symptoms only appear at the site of contact, systemic nickel allergy syndrome (SNAS) can cause symptoms elsewhere. […] Nickel allergy symptoms typically include redness, itching, rash, blisters, and skin changes like dry patches resembling a burn. These symptoms often begin within hours to days after exposure to nickel. Systemic symptoms can include headache, fatigue, and gastrointestinal problems. […] Allergy to nickel is quite common, affecting approximately 15% of the population. It’s more prevalent among women, likely due to increased exposure through jewelry. Nickel allergy develops over time through prolonged exposure and can cause skin rash, itching, and redness. […] Approximately 15% of the American population is allergic to nickel. Nickel allergies are more common in women and girls, likely due to more frequent exposure from jewelry. Symptoms include skin rash or inflammation in response to contact with items containing nickel.

• #42

  https://www.wyndly.com/blogs/learn/nickel-allergy?srsltid=AfmBOopK6tVjEFzC1L8bf_1WoaqUjDsHRgxhQTXtG6Cjp-YDTNvznoTx

  In rare instances, individuals may experience systemic nickel allergy syndrome (SNAS). This involves not only skin reactions, but also respiratory and gastrointestinal symptoms like those seen in allergy symptoms in children, including nausea, vomiting, and diarrhea. […] Nickel allergy prevention primarily involves avoiding all contact with nickel. Since nickel is common in many everyday items, this can require careful scrutiny of products before use. […] Remember, nickel allergy develops after repeated or prolonged exposure to items containing nickel. Therefore, minimizing contact with nickel-containing items is the most effective prevention strategy. […] If you suspect you may have developed a nickel allergy, seeking advice from a healthcare professional is crucial to manage symptoms effectively and prevent further allergic reactions.

• #43 Nickel Allergy | New York Allergy and Sinus Centers

  https://www.nyallergy.com/nickel-allergy/

  A family history of nickel allergy, along with existing sensitivities to other metals, can further predispose individuals to this condition. […] Understanding which foods contain nickel is essential for maintaining overall health and preventing allergic reactions. […] There is evidence suggesting a genetic component to nickel allergy. Individuals with a family history of nickel sensitivity may be more likely to develop the allergy themselves. […] Systemic nickel allergy syndrome (SNAS) is a condition where individuals with allergic to nickel experience systemic symptoms upon exposure to nickel. Symptoms can include headaches, fatigue, gastrointestinal distress, and skin reactions.

• #44 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy results in a skin response after the skin comes in contact with an item that releases a large amount of nickel from its surface. […] The pathophysiology is divided into induction elicitation phases. Induction is the critical phase (immunological event) when skin contact to nickel results in antigen presentation to the T cells, and T cell duplication (cloning) occurs. […] The metal cation Ni++ is a low molecular weight hapten that easily penetrates the stratum corneum (top layer of skin). […] The complex is predominantly expressed on major histocompatibility complex (MHC) II, which activates and clonally expands naive CD4+ T cells. […] The pathophysiology of systemic nickel allergy syndrome (SNAS) is not well understood.

• #45 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Nickel-Allergy.aspx

  Nickel or nickel sulfate hexahydrate is a common allergen that causes contact dermatitis in sensitized individuals. […] Systemic responses can also result from dietary ingestion of nickel. […] Nickel ingestion through the diet in nickel-sensitive people triggers a series of changes in the immune system that can lead to the development of clinical reactions. […] The mechanism of absorption of ingested nickel in the body is not fully understood yet, though it has been proved that vitamin C and iron are capable of decreasing the absorption of dietary nickel.

• #46 Nickel Allergy and Autoimmune Disease

  https://www.verywellhealth.com/nickel-allergy-and-autoimmune-disease-5198646

  A nickel allergy could make you more susceptible to autoimmune disease, according to research. Nickel allergy is sometimes called nickel allergic contact dermatitis (NACD). […] Nickel is the most common cause of metal allergies. And its being increasingly tied to several types of autoimmune disease. Researchers are looking into common underlying mechanisms to understand how the two may be related. […] Nickel allergy can be acquired anytime during your lifetime, unlike some allergies like food allergies that often occur very early in life. […] Your sweat and other bodily fluids can leach nickel from stainless steel and other alloys. Then your skin absorbs the metal. The allergy is often caused by direct and prolonged exposure to items that release a lot of nickel. Once youre sensitized to it, even small amounts of nickel exposure may be a problem.

• #47 Nickel Allergy and Autoimmune Disease

  https://www.verywellhealth.com/nickel-allergy-and-autoimmune-disease-5198646

  Researchers havent yet uncovered the cause of autoimmune diseases. But its believed to involve a genetic predisposition plus exposure to something that confuses your immune system. […] The precise relationship between these illnesses is unclear, but allergies and autoimmune diseases both involve similar immune-system activity. Several studies have noted a link between nickel allergies and autoimmune disease. […] A 2014 paper suggested that a systemic nickel allergy is a risk factor for developing autoimmune thyroid disease. Another study found that people with nickel allergy from oral exposure were especially likely to have an autoimmune disease. […] The International Academy of Oral Medicine and Toxicology (IOAMT) reported that metal can cause inflammation. And that inflammation can lead to the development of both allergic and autoimmune diseases.

• #48 Nickel Allergy and Autoimmune Disease

  https://www.verywellhealth.com/nickel-allergy-and-autoimmune-disease-5198646

  Researchers havent yet uncovered the cause of autoimmune diseases. But its believed to involve a genetic predisposition plus exposure to something that confuses your immune system. […] The precise relationship between these illnesses is unclear, but allergies and autoimmune diseases both involve similar immune-system activity. Several studies have noted a link between nickel allergies and autoimmune disease. […] A 2014 paper suggested that a systemic nickel allergy is a risk factor for developing autoimmune thyroid disease. Another study found that people with nickel allergy from oral exposure were especially likely to have an autoimmune disease. […] The International Academy of Oral Medicine and Toxicology (IOAMT) reported that metal can cause inflammation. And that inflammation can lead to the development of both allergic and autoimmune diseases.

• #49 Nickel Allergy and Autoimmune Disease

  https://www.verywellhealth.com/nickel-allergy-and-autoimmune-disease-5198646

  A 2020 review of research found that metals may suppress or damage the immune system. That may lead to allergies and/or autoimmunity, depending on your susceptibility. […] Research suggests that metal allergies, in general, may be especially linked to autoimmune conditions that affect connective tissues, such as rheumatoid arthritis, Sjgrens disease, systemic lupus erythematosus, spondyloarthritis, scleroderma, and polymyalgia rheumatica. […] Nickel allergy may lead to autoimmune disease. Nickel is widely used in everyday items plus medical devices and implants. Allergies develop after prolonged exposure causes the immune system to misfire. Autoimmune disease is caused by the immune system mistaking something harmless for something threatening.

• #50 Nickel Allergy – ECARF

  https://www.ecarf.org/en/information-portal/allergies-overview/nickel-allergy/

  Nickel allergy is a contact allergy (also referred to as type IV or delayed type hypersensitivity). […] This delay is caused by what are called helper T cells (medical term: T-lymphocytes). […] In a contact allergy, the helper T cells remember a presumably harmless substance like nickel. […] Nickel is the most common contact allergen in the world. […] True symptoms in the form of allergic eczema triggered by nickel or other substances develop in 8.0% of German adults over the course of their lifetime. […] Nickel is virtually everywhere. […] Since the 1970s, jeans buttons, costume jewellery and piercing jewellery have been the main offenders. […] An important step in the diagnostic procedure is the patient history. […] A patch test is used to diagnose a contact allergy. […] The most effective method for relieving symptoms is to avoid the allergy-triggering substance. […] In rare cases, the nickel content in food can exacerbate eczema in patients with a severe nickel allergy.

• #51 Nickel Allergy: Genetics, causes, natural solutions

  https://www.geneticlifehacks.com/nickel-allergy-genes/

  Nickel allergy is a common cause of allergic contact dermatitis (rash). It is estimated that 8-20% of people are sensitive to nickel. […] While genetic susceptibility plays a role, nickel allergy is caused by exposure to nickel, often for a long period of time. […] Systemic symptoms of nickel allergy can include respiratory, gastrointestinal, and neurological symptoms from eating foods that contain nickel (or an implanted device that contains nickel). […] If you have a nickel allergy, you may also be sensitive to certain foods that contain nickel or other metals that cross-react with nickel. […] Nickel causes the cell to increase inflammation and oxidative stress. This can lead to cell death at higher levels.

• #52

  https://www.wyndly.com/blogs/learn/nickel-allergy-testing?srsltid=AfmBOoohmR0_azIc1ZcMXunkTWOibDdgXt2MUuYTguC5VObGZFsM7VNL

  Nickel allergies are more common among women and girls, primarily due to more frequent exposure from jewelry and other metal items. However, anyone can develop a nickel allergy at any age. […] Yes, a nickel allergy can affect areas of the body not directly in contact with the metal. Despite the common belief that nickel allergy symptoms only appear at the site of contact, systemic nickel allergy syndrome (SNAS) can cause symptoms elsewhere. […] Nickel allergy symptoms typically include redness, itching, rash, blisters, and skin changes like dry patches resembling a burn. These symptoms often begin within hours to days after exposure to nickel. Systemic symptoms can include headache, fatigue, and gastrointestinal problems. […] Allergy to nickel is quite common, affecting approximately 15% of the population. It’s more prevalent among women, likely due to increased exposure through jewelry. Nickel allergy develops over time through prolonged exposure and can cause skin rash, itching, and redness. […] Approximately 15% of the American population is allergic to nickel. Nickel allergies are more common in women and girls, likely due to more frequent exposure from jewelry. Symptoms include skin rash or inflammation in response to contact with items containing nickel.

• #53 Nickel Sensitivity in Children Due to Using Stainless Steel Crowns: A Narrative Review – Journal of Pediatrics Review

  https://jpr.mazums.ac.ir/browse.php?a_id=363&slc_lang=en&sid=1&ftxt=1&html=1

  Nickel causes allergies in almost 10% of the population and was identified as a mutagenic and carcinogenic agent in some studies. […] Studies suggested that the average prevalence of nickel allergy in Eastern Europe and North America is approximately 8.6% (0.7%-27.8%); it is more prevalent in females. […] Investigations also indicated that 1.1 million American children are potentially allergic to nickel. […] It has also been reported that 8% to 10% of children and adolescents in the European general population present nickel allergy; however, this prevalence was about 23.7% in the children of North America between 1994 to 2014. […] Nickel ion is a common cause of contact allergies and hypersensitivity reactions. […] Nickel released from appliances, like orthodontic braces causes allergic reactions and reduces the strength of appliances.

• #54 Nickel allergy: How to avoid exposure and reduce symptoms

  https://www.aad.org/public/diseases/eczema/insider/nickel-allergy

  Nickel is one of the most common causes of allergic contact dermatitis: a skin rash or irritation caused by touching an allergen. In fact, it is estimated that more than 18 percent of people in North America are allergic to nickel, including 11 million children in the U.S. […] If you have a nickel allergy, the best way to avoid symptoms is to avoid objects containing nickel. However, this can be challenging, since nickel is present in many common household items. […] Rashes caused by a nickel allergy are not life-threatening, but they can be uncomfortable. If you think you have an allergy, or if you have a rash that blisters, becomes infected, or comes and goes, see a board-certified dermatologist for the proper diagnosis.

• #55 Nickel Sensitivity in Children Due to Using Stainless Steel Crowns: A Narrative Review – Journal of Pediatrics Review

  https://jpr.mazums.ac.ir/browse.php?a_id=363&slc_lang=en&sid=1&ftxt=1&html=1

  Nickel causes allergies in almost 10% of the population and was identified as a mutagenic and carcinogenic agent in some studies. […] Studies suggested that the average prevalence of nickel allergy in Eastern Europe and North America is approximately 8.6% (0.7%-27.8%); it is more prevalent in females. […] Investigations also indicated that 1.1 million American children are potentially allergic to nickel. […] It has also been reported that 8% to 10% of children and adolescents in the European general population present nickel allergy; however, this prevalence was about 23.7% in the children of North America between 1994 to 2014. […] Nickel ion is a common cause of contact allergies and hypersensitivity reactions. […] Nickel released from appliances, like orthodontic braces causes allergic reactions and reduces the strength of appliances.

• #56 Nickel Sensitivity in Children Due to Using Stainless Steel Crowns: A Narrative Review – Journal of Pediatrics Review

  https://jpr.mazums.ac.ir/browse.php?a_id=363&slc_lang=en&sid=1&ftxt=1&html=1

  Nickel causes allergies in almost 10% of the population and was identified as a mutagenic and carcinogenic agent in some studies. […] Studies suggested that the average prevalence of nickel allergy in Eastern Europe and North America is approximately 8.6% (0.7%-27.8%); it is more prevalent in females. […] Investigations also indicated that 1.1 million American children are potentially allergic to nickel. […] It has also been reported that 8% to 10% of children and adolescents in the European general population present nickel allergy; however, this prevalence was about 23.7% in the children of North America between 1994 to 2014. […] Nickel ion is a common cause of contact allergies and hypersensitivity reactions. […] Nickel released from appliances, like orthodontic braces causes allergic reactions and reduces the strength of appliances.

• #57 Nickel Allergy: Signs, Symptoms, Causes & Treatment

  https://www.parashospitals.com/blogs/nickel-allergy-signs-symptoms-causes-treatment

  Nickel allergy is the most common causes of contact allergic dermatitis. […] The exact cause of nickel allergy is unknown. Doctors believe that it is the adverse immune response that occurs when someone is allergic to nickel comes in contact with it. […] In people with nickel allergy, the immune system mistakes nickel as a dangerous foreign body and secrete chemicals to ward off the threat, triggering an allergic reaction. […] It may take recurrent or extended exposure to nickel to develop the allergy. […] However once the body becomes allergic to nickel, the immune system will always be sensitive to it. […] According to studies, women are more likely to develop nickel allergy than men. […] Nickel allergy can also affect areas that are not in contact with the metal.

• #58 Nickel Allergy

  https://dermnetnz.org/topics/nickel-allergy

  Nickel allergy is one of the most common causes of contact allergic dermatitis. In affected individuals, dermatitis (also called eczema) develops in places where nickel-containing metal is touching the skin. […] Nickel allergy may develop at any age and in males and females. Once this nickel allergy has developed, it persists for many years, often life-long. […] It has been suggested that in nickel allergic people pompholyx may be due to nickel in the diet. […] Unfortunately, desensitization with injections or pills is not possible so the allergy tends to persist long-term. […] This diet low in nickel-containing foods has been suggested to patients with severe contact allergy to nickel. Its efficacy is unknown. Nickel cannot be completely avoided from diet.

• #59 Nickel (Jewelry) Allergies: Symptoms, Treatments, and Avoid Triggers

  https://www.webmd.com/allergies/nickel-jewelry-allergy

  If earrings make your earlobes itch or your necklace leaves a rash around your neck, you may be allergic to nickel. […] Its one of the most common skin allergies, in part because nickel is used in so many things, including jewelry, cell phones, coins, zippers, eyeglass frames, belt buckles, and keys. […] Your doctor can often diagnose a nickel allergy by looking at your skin and asking if youve touched anything metal. […] Once a nickel allergy develops, it often lasts your whole life. […] The most important thing you can do is avoid contact with objects that can cause a reaction. […] If your skin is cracked or blistered, you should take off any metal jewelry right away and see your doctor for treatment to avoid getting an infection. […] If you’re extremely sensitive to nickel, you may also need to avoid nickel-rich foods such as mixed nuts and chocolate.

• #60 Nickel allergy: causes and treatment – Torrinomedica

  https://www.torrinomedica.it/english/dietology/nickel-dietology/nickel-allergy-causes-and-treatment/

  Nickel allergy, a common contact dermatitis, arises from sensitization to nickel exposure. […] Nickel allergy is classified as a type of allergic contact dermatitis, which occurs when the immune system reacts to nickel after direct skin contact. […] The condition arises when nickel ions penetrate the skin, triggering an immune response that leads to inflammation and irritation. […] The prevalence of nickel allergy has increased in recent decades, largely due to the widespread use of nickel in jewelry, clothing fasteners, and various household items. […] Understanding the mechanisms behind nickel allergy is crucial for effective management. The immune systems response involves sensitization, where the initial exposure to nickel leads to the development of specific T-cells. […] Nickel is commonly found in a variety of products, making it challenging for individuals with an allergy to avoid exposure.

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