Materiały źródłowe

• #1 Nickel allergy – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nickel-allergy/diagnosis-treatment/drc-20351534

  Your doctor may prescribe one of the following medications to reduce irritation and improve the condition of a rash from a nickel allergy reaction: […] The first step in treating nickel allergy is avoiding contact with the metal. There’s no cure for nickel allergy. Once you develop a sensitivity to nickel, you’ll develop a rash (contact dermatitis) whenever you come into contact with the metal. […] This treatment involves exposing your skin to controlled amounts of artificial ultraviolet light. It’s generally reserved for people who haven’t gotten better with topical or oral steroids. It can take months for phototherapy to have an effect on a nickel allergy reaction. […] You may use some of the following treatments at home to treat contact dermatitis due to nickel allergy. If these treatments don’t help or the rash worsens, contact your doctor. Home remedies include the following: […] Avoid certain over-the-counter ointments, such as antibiotic creams, which may contain ingredients particularly neomycin that can worsen an allergic reaction. […] What are the treatments available for nickel allergy, and which do you recommend?

• #2 Nickel Allergy: Rash, Symptoms, Testing, Treatment & Prevention

  https://my.clevelandclinic.org/health/diseases/17842-nickel-allergy

  Nickel allergy can develop at any time. Once you have a nickel allergy, it never goes away. But you can treat it by avoiding nickel or using medications. […] Theres no cure for nickel allergy. The best treatment is to avoid substances containing nickel. But as that cant always happen, your provider may suggest medications, including: […] If medications dont help relieve your symptoms, your provider may recommend light therapy (phototherapy). This therapy uses ultraviolet (UV) light on your skin. It can take months of phototherapy treatment to show improvement. […] You can do many things at home to help relieve nickel allergy symptoms. You can try treatments like: […] Dont use over-the-counter antibiotic treatments at home. These may make your symptoms worse. […] Nickel allergy usually isnt life-threatening. Because theres no cure, avoiding symptoms can be a lifelong challenge. But you can manage the allergy by staying away from items and food containing nickel and/or with proper treatment.

• #3 Nickel Allergies Symptoms, Tests, and Treatment

  https://www.healthline.com/health/allergies/nickel

  Once it has developed, a nickel allergy is unlikely to go away. The only way to treat a nickel allergy is to avoid all items and foods containing nickel. […] Theres no cure for a nickel allergy. As with other allergies, the best treatment is to avoid the allergen. […] However, your doctor may prescribe one of the following medications to help reduce the skin irritation caused by a nickel allergy: corticosteroid cream, nonsteroidal cream, oral corticosteroid, such as prednisone, oral antihistamine, such as fexofenadine (Allegra) or cetirizine (Zyrtec). […] Make sure to follow your doctors instructions carefully when using these medications. […] The following home treatments may also help: calamine lotion, moisturizing body lotion, wet compresses. […] Tell your doctor if treatments arent helping or if theyre making symptoms worse. […] You should also contact your doctor immediately if you experience increased redness, pain, or pus in the affected area. These symptoms may be a sign of infection and need to be treated with antibiotics.

• #4 Nickel allergy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/nickel-allergy

  It may take repeated or prolonged exposure to items containing nickel to develop a nickel allergy. Treatments can reduce the symptoms of nickel allergy. Once you develop a nickel allergy, however, you’ll always be sensitive to the metal and need to avoid contact. […] The first step in treating nickel allergy is avoiding contact with the metal. There’s no cure for nickel allergy. Once you develop a sensitivity to nickel, you’ll develop a rash (contact dermatitis) whenever you come into contact with the metal. […] Your doctor may prescribe one of the following medications to reduce irritation and improve the condition of a rash from a nickel allergy reaction: […] Corticosteroid cream, such as clobetasol (Clobex, Cormax, others) and betamethasone dipropionate (Diprolene). Long-term use of these can lead to skin thinning.

• #5 Two Cents About Nickel Allergy

  https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/nickel

  Nickel AllergyNickel is a leading cause of allergic contact dermatitisan itchy rash that develops when a persons skin touches a normally harmless material. […] While there is no cure for nickel allergy, allergic reactions can be prevented by avoiding products that contain it. […] Your allergist / immunologist can recommend the best treatment for an allergic reaction. If the rash is small, a doctor may prescribe medicated creams (topical corticosteroids) to rub on the irritated skin. For larger or more serious out-breaks, pills may be required. […] Talk to your allergist / immunologist if you think you have a nickel allergy. An allergist / immunologist is the best doctor to diagnose nickel allergy and prescribe treatments.

• #6 Nickel allergy – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nickel-allergy/symptoms-causes/syc-20351529

  Nickel allergy is a common cause of allergic contact dermatitis an itchy rash that appears where your skin touches a usually harmless substance. […] Treatments can reduce the symptoms of nickel allergy. Once you develop a nickel allergy, however, you’ll always be sensitive to the metal and need to avoid contact. […] If you’ve already been diagnosed with nickel allergy and are sure you’re reacting to nickel exposure, use the over-the-counter treatments and home remedies your doctor has previously recommended. […] However, if these treatments don’t help, call your doctor. […] The best strategy to prevent a nickel allergy from developing is to avoid prolonged exposure to items containing nickel. If you already have a nickel allergy, the best way to prevent an allergic reaction is to avoid contact with the metal.

• #7 Nickel allergy – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nickel-allergy/symptoms-causes/syc-20351529

  Home test kits are available to check for nickel in metal items. […] Avoid jewelry that contains nickel. Purchase jewelry that’s made of materials that aren’t likely to cause allergic reactions. […] Be sure that your earring backings also are made of hypoallergenic materials. […] If you have to be exposed to nickel at work, creating a barrier between you and the nickel may help. If your hands have to touch nickel, wearing gloves may help.

• #8 Nickel allergy: How to avoid exposure and reduce symptoms

  https://www.aad.org/public/diseases/eczema/insider/nickel-allergy

  If you have a nickel allergy, the best way to avoid symptoms is to avoid objects containing nickel. To avoid exposure and reduce symptoms, board-certified dermatologists recommend following these tips. […] To avoid exposure and reduce symptoms, dermatologists recommend the following tips: […] Choose jewelry carefully. Its common for a nickel allergy to develop from wearing jewelry containing nickel. […] Check your clothing. It’s also common for belt buckles, bra hooks, and metal buttons, zippers and snaps to contain nickel. […] Cover electronics. Recent reports suggest that some electronic devices, including cell phones, laptops, and tablets, may contain nickel. […] Substitute household objects containing nickel with objects made of other materials. […] Avoid foods containing nickel if you are extremely sensitive to nickel. […] Rashes caused by a nickel allergy are not life-threatening, but they can be uncomfortable. If you think you have an allergy, or if you have a rash that blisters, becomes infected, or comes and goes, see a board-certified dermatologist for the proper diagnosis.

• #9 Nickel allergy – Wikipedia

  https://en.wikipedia.org/wiki/Nickel_allergy

  Nickel allergy is any of several allergic conditions provoked by exposure to the chemical element nickel. The main treatment for it is avoiding contact with nickel-releasing metals, such as inexpensive jewelry. […] Once a nickel allergy is detected, the best treatment is avoidance of nickel-releasing items. The top 13 categories that contain nickel include beauty accessories, eyeglasses, money, cigarettes, clothes, kitchen and household, electronics and office equipment, metal utensils, aliment, jewelry, batteries, orthodontic and dental appliances, and medical equipment. Other than strict avoidance of items that release free nickel, there are other treatment options for reduction of exposure. The first step is to limit friction between skin and metallic items. […] In addition to avoidance, healthcare providers may prescribe additional creams or medications to help relieve the skin reaction.

• #10 Nickel Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK557638/

  Nickel allergy is a type of contact dermatitis caused by direct contact with nickel. […] This activity reviews the evaluation and treatment of nickel allergy and highlights the role of the interprofessional team in managing patients with this condition. […] Summarize the treatment and management options available for patients with a nickel allergy. […] The key element of appropriate treatment and management of allergic contact dermatitis due to nickel allergy is the identification and removal of the source object. […] If the patient is determined to have a nickel allergy, management begins with avoidance of repeat exposure, as this is the most effective treatment option. […] Patients should also avoid foods that are routinely high in nickel content, such as cocoa, chocolate, oatmeal, various nuts, and legumes.

• #10 Nickel Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK557638/

  For cases not improved by the conservative measures listed above, the first-line pharmacologic therapy utilized is topical corticosteroids, beginning with low potency agents and advancing therapies as indicated. […] Topical calcineurin inhibitors (e.g., tacrolimus) are an alternative therapy available. […] In cases of nickel allergies that are resistant to the above therapeutic modalities, referral to dermatology may be beneficial. […] Patient education will center around avoidance of nickel, including identifying potential exposure sources and lifestyle modifications. […] Avoidance is the single best way to deter nickel allergy dermatitis.

• #11 Contact Dermatitis, Nickel (Nickel allergic contact dermatitis, allergic contact dermatitis to nickel, nickel allergy) – Dermatology Advisor

  https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/contact-dermatitis-nickel-nickel-allergic-contact-dermatitis-allergic-contact-dermatitis-to-nickel-nickel-allergy/

  The diagnosis of contact dermatitis to nickel can be made clinically with confirmation by patch testing. […] The first step in confirming the diagnosis is to observe whether the problem resolves with avoidance of the substance. If avoidance or empiric treatment does not resolve the skin rash, patch testing can be done to further evaluate the allergen present. […] Treatment options are summarized in Table IV. […] Most barrier creams are made with silicone (Barrier cream 222, LaRoche Posey Biomedic Barrier cream 33% silicone) or dimethicone, which reduce or in some cases prevent the nickel from reaching the skin in high enough concentrations to cause a reaction. […] Typically, jewelry made of 14K gold or higher, silver, and platinum are safe to use in the nickel-allergic patient. […] Oral hyposensitization may be attempted. It has had variable results.

• #12 Nickel Allergy: How to Spot, Treat & Avoid It

  https://getcurex.com/allergens-and-symptoms/allergy-symptoms-immunotherapy-nickel?srsltid=AfmBOorXJ8_cyCHJtrFtPUbAfSfk622gOVsLuspmiEM6UnfFNhRMRPrF

  Almost any product that is in contact with your skin for extended periods can potentially contain nickel. […] To further minimize skin exposure to nickel, consider using barrier creams. […] It is crucial to maintain a balanced diet as your body needs various nutrients, which you might lose while avoiding nickel-rich foods. […] Avoiding such foods can help manage and reduce allergic responses. […] Nickel allergy often develops from prolonged exposure to nickel-containing items. […] To minimize exposure, consider using products labeled „nickel-free” or protective covers for items frequently handled. […] At-home sublingual immunotherapy is a safe alternative to allergy shots that can be done at the comfort of your home.

• #13 Management of contact dermatitis due to nickel allergy: an update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3047925/

  Nickel contact dermatitis represents an important morbidity that can lead to inability to work, a decrease quality of life and significant healthcare expenses. Therefore its management is of great importance. This article reviews diagnostic, preventive and therapeutic strategies in this field. […] Management of nickel contact dermatitis include early diagnosis and preventive and therapeutic strategies. […] Therapy of nickel contact dermatitis can be very challenging and depends on clinical manifestations. […] The only way to prevent recurrence is avoiding skin contact with metallic items that release nickel. It has been documented that this strategy results in a statistically significant decrease in the frequency of hand eczema in nickel-sensitive individuals. […] Topical steroids are very useful and represent the first-line treatment. Potency should be chosen according to the body sites, as low potency steroids are recommended for face and flexural areas and high potency agents might be used for other sites as palms and soles.

• #14 Management of contact dermatitis due to nickel allergy: an update

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3047925/

  Calcineurin inhibitors are currently approved for the treatment of atopic dermatitis but not ACD. Advantages over topical corticosteroids include that they do not cause cutaneous atrophy or glaucoma or cataracts when applied near the eye. […] It has been shown that disulfiram can chelate nickel, interfere with its absorption and metabolism and then improve nickel contact dermatitis, particularly pompholyx. […] These substances promote chelation of nickel, and thus prevent its antigenic properties; they are usually used in combination with others treatments, such as topical steroids. […] Food is important source of nickel and daily ingestion depends both on the type of food and on the production environment. […] Since nickel sensitization is a hapten-specific immunological process, it is possible to induce immune tolerance to this metal. […] This oral retinoid has been described as a promising new option in treatment of chronic, severe, and refractory hand dermatitis.

• #15 Nickel allergy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/nickel-allergy

  Nonsteroidal creams, such as tacrolimus (Protopic). The most common side effect is temporary stinging at the application site. […] Oral corticosteroid, such as prednisone, if the reaction is severe or a rash covers a large area. These drugs can cause a host of side effects, including weight gain, mood swings and increased blood pressure. […] Oral antihistamines, for relief of itching. However, these may not be very effective for skin itching. […] This treatment involves exposing your skin to controlled amounts of artificial ultraviolet light. It’s generally reserved for people who haven’t gotten better with topical or oral steroids. It can take months for phototherapy to have an effect on a nickel allergy reaction. […] You may use some of the following treatments at home to treat contact dermatitis due to nickel allergy. If these treatments don’t help or the rash worsens, contact your doctor. Home remedies include the following:

• #16 Contact dermatitis: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000869.htm

  Your provider will recommend treatment based on what is causing the problem. In some cases, the best treatment is to do nothing to the area. […] Often, treatment includes washing the area with a lot of water to get rid of any traces of the irritant that are still on the skin. You should avoid further exposure to the substance. […] Emollients or moisturizers help keep the skin moist, and also help skin repair itself. They protect the skin from becoming inflamed again. They are a key part of preventing and treating irritant contact dermatitis. […] Topical corticosteroid medicines are commonly used to treat contact dermatitis. […] Your provider may also prescribe other creams or ointments, such as tacrolimus or pimecrolimus, to use on the skin. […] In severe cases, you may need to take corticosteroid pills. Your provider will start you on a high dose and your dose will be slowly reduced over about 12 days. You may also receive a corticosteroid shot. […] Wet dressings and soothing anti-itch (antipruritic) lotions may be recommended to reduce other symptoms. […] Topical corticosteroids should be used only for short periods. Long-term use increases the risk of developing more irritant contact dermatitis.

• #17 Nickel Allergy Symptoms & Treatment | Baptist Health

  https://www.baptisthealth.com/care-services/conditions-treatments/nickel-allergy

  How Is a Nickel Allergy Treated? There is no cure for a nickel allergy. Treatment focuses instead on suppressing or controlling symptoms. Major forms of treatment are: Topical medications: Corticosteroid and nonsteroidal creams can be applied directly to inflamed patches of skin. Oral medications: Oral corticosteroids are often prescribed for more serious outbreaks. Oral antihistamines can help control itching, though sometimes less effectively for skin than for nasal passages. Phototherapy: Phototherapy is the medical treatment of skin by regular exposure to ultraviolet light. It is typically used only when topical and oral medications have failed to reduce symptoms and often requires repeated treatments over long periods of time to be effective. […] There is no long-term fix for a nickel allergy. It is possible, however, to control nickel allergies, with a combination of symptom treatment and prevention.

• #18 Allergic Contact Dermatitis: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/1049216-overview

  Nickel is the leading cause of allergic contact dermatitis in the world. The incidence of nickel allergic contact dermatitis in North America is increasing; in contrast, new regulations in Europe have resulted in a decreasing prevalence of nickel allergy in young and middle-aged women. […] Allergic contact dermatitis to nickel typically is manifested by dermatitis at the sites where earrings or necklaces containing nickel are worn or where metal objects containing nickel are in contact with the skin. […] Disulfiram: Occasionally, an individual who is highly allergic to nickel and has severe vesicular hand dermatitis will benefit from treatment with disulfiram (Antabuse); the drug has a chelating effect.

• #19 Contact Dermatitis, Nickel (Nickel allergic contact dermatitis, allergic contact dermatitis to nickel, nickel allergy) – Dermatology Advisor

  https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/contact-dermatitis-nickel-nickel-allergic-contact-dermatitis-allergic-contact-dermatitis-to-nickel-nickel-allergy/

  Antihistamines can be used to relieve pruritus. […] Topical PUVA may be used with varying results in patients with chronic allergic contact dermatitis to nickel of the hands. […] Patients should be educated to avoid the nickel allergen. […] Those that are extremely sensitive to nickel and have repeated reactions should be educated in avoiding foods that contain nickel. […] A nickel-reduced diet and strict avoidance of topical nickel is a must.

• #20 Nickel allergy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/nickel-allergy

  Use soothing lotions, such as calamine lotion, which may ease itching. […] Moisturize regularly. Your skin has a natural barrier that’s disrupted when it reacts to nickel and other allergens. Using emollient creams or lotions, such as petroleum jelly or mineral oil, could reduce your need for topical corticosteroids. […] Apply wet compresses, which can help dry blisters and relieve itching. Soak a clean cloth in tap water or Burow’s solution, an over-the-counter medication containing aluminum acetate.

• #21 Nickel Allergy

  https://dermnetnz.org/topics/nickel-allergy

  Treatment is often necessary for nickel dermatitis. […] Compresses Dry up blisters with diluted vinegar compresses. Do not use these if the skin is dry. […] Topical steroids Apply topical steroid to the dermatitis as directed by your doctor. […] Antibiotics may be necessary for secondary infection of nickel dermatitis (impetigo). […] Apply soothing emollient creams frequently to relieve itch and dry skin. […] Unfortunately, desensitization with injections or pills is not possible so the allergy tends to persist long-term. […] A low-nickel diet is only rarely helpful.

• #22 Nickel Allergy – ECARF

  https://www.ecarf.org/en/information-portal/allergies-overview/nickel-allergy/

  The most effective method for relieving symptoms is to avoid the allergy-triggering substance. People who are allergic to nickel should stay away from everyday objects containing nickel and avoid prolonged skin contact. If contact cannot be avoided completely, safety measures such as gloves or protective clothing can help. […] If eczema persists despite strict allergen avoidance, cortisone creams can be used to relieve the symptoms. […] In rare cases, the nickel content in food can exacerbate eczema in patients with a severe nickel allergy. But before putting such patients on a low nickel diet, a doctor should perform an oral provocation test with nickel. The thresholds and trigger foods vary by individual, and patients should therefore seek the help of a nutrition specialist in order to determine which foods are safe and which need to be avoided. […] Research is currently underway to investigate immunotherapy options for nickel allergy.

• #23 Systemic Nickel Allergy Syndrome (SNAS) – Research Article

  https://www.gavinpublishers.com/article/view/systemic-nickel-allergy-syndrome-taking-stock-of-medical-nutrition-therapy-snas-and-nutrition

  Nickel allergy mainly affects adults (approximately 8% to 19% of the general population) and children and adolescents (8% to 10%) […] Until now, knowledge about the treatment of SNAS remains unclear; therefore, this narrative review proposes an overview of the current knowledge of Systemic Nickel Allergy Syndrome (SNAS) associated with symptomatology, diagnosis, and with medical nutrition treatment-related care practices. […] Gold standard for SNAS diagnosis is based on an Oral Provocation Test (OPT), called also Nickel “Oral Challenge” (NOC) that can be performed only after 4-6 weeks of a Nickel-free diet. […] As far as “Nickel Free diet” (N-F diet) concerns, the practical limitation is that there’s no standard dietetic protocol universally accepted and recommended. […] Many authors recommend the BraMaNi diet by Braga and Maccarinelli, developed to minimize additive content and vasoactive amines in foods.

• #24 Systemic Nickel Allergy Syndrome (SNAS) – Research Article

  https://www.gavinpublishers.com/article/view/systemic-nickel-allergy-syndrome-taking-stock-of-medical-nutrition-therapy-snas-and-nutrition

  Results have shown an improvement of gastrointestinal and cutaneous symptoms following this “restriction” period. […] Adherence to a Nickel free diet is essential during the oral provocation test period to avoid false positive results. […] Up until now, a Nickel free diet is the most used treatment for SCD and SNAS, even if it is difficult for patients to adhere to since it is very selective and restrictive, affecting food choices and the long term quality of life of patients. […] Most of the nutritional protocols are very restrictive, and only a few SNAS patients are allowed to reintroduce the forbidden foods after a long period, whereas the majority of them have to maintain a lifelong Nickel free diet. […] Nickel oral hyposensitization is a mechanism of immune tolerance in a Nickel-sensitized patient through the ingestion of low Nickel doses.

• #25 Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet?

  https://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm16027

  Irritable bowel syndrome (IBS) is characterized by chronic abdominal pain or discomfort accompanied by abnormal bowel movements. In sensitized subjects, ingested nickel (Ni) may induce gastrointestinal symptoms similar to IBS, in addition to typical systemic cutaneous lesions (systemic nickel allergy syndrome [SNAS]). A low nickel diet could improve the systemic manifestations. […] This pilot study shows that low Ni diet improves gastrointestinal symptoms in patients with IBS and SNAS. […] Our data demonstrate that: (1) Ni allergy is highly prevalent in patients affected by IBS, with a higher frequency in females; (2) a low Ni diet determines a clear improvement on both gastrointestinal symptoms and state of general physical health in IBS patients with concomitant Ni allergy; and (3) the change of IP after low Ni diet is influenced by skin reactivity to Ni and IBS subtypes.

• #26 Nickel allergy diagnosis and desensitization

  https://www.linkedin.com/pulse/nickel-allergy-diagnosis-desensitization-gianluca-tognon

  Nickel sulfate (5 mg/week for six weeks) significantly reduced the degree of contact allergy when administered to patients allergic to nickel. […] Minelli et al. showed that oral hyposensitization with increasing doses of nickel sulfate combined with an elimination diet could induce either partial or total remission of symptoms after one year and four months. […] The term „nickel vaccination” is often used to identify commercial oral hyposensitizing treatments available in some countries. However, the efficacy of these treatments has yet to be ultimately proven. […] The results of all these studies suggest that hyposensitization with oral nickel sulfate is a promising option for the treatment of nickel-allergic subjects.

• #27

  https://www.aaaai.org/allergist-resources/ask-the-expert/answers/old-ask-the-experts/nickel

  I have seen a few studies that showed some promise in this area, but will probably advise patient that this therapy is still in experimental phase, and will not recommend at this point. […] I am not aware of anyone in the US with specific expertise in performing nickel desensitization. […] If nickel desensitization is to be considered, the available literature suggests a daily dose of 1.5 mcg of nickel is superior to lower doses for cutaneous and gastrointestinal symptoms resulting presumably from nickel in the diet. […] I am not aware of any desensitization to contact reactions to nickel but oral treatment and injections have been tried for contact urushiol sensitivity. […] The studies in the medical literature use nickel sulfate mixed with microcrystalline cellulose in gelatin capsules. […] There are published diets that are nutritionally sound and without sufficient nickel to provoke systemic symptoms.

• #28 Systemic Nickel Allergy Syndrome (SNAS) – Research Article

  https://www.gavinpublishers.com/article/view/systemic-nickel-allergy-syndrome-taking-stock-of-medical-nutrition-therapy-snas-and-nutrition

  Nevertheless, over the years different studies investigating Nickel oral hyposensitization to treat SNAS have not yet provided sufficient results to consider this technique as a definitive solution for treating patients affected by this syndrome. […] At present, it is impossible to draw definite evidence-based recommendations about the nutritional support and management of SNAS.

• #29 Contact Dermatitis, Nickel (Nickel allergic contact dermatitis, allergic contact dermatitis to nickel, nickel allergy) – Dermatology Advisor

  https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/contact-dermatitis-nickel-nickel-allergic-contact-dermatitis-allergic-contact-dermatitis-to-nickel-nickel-allergy/

  The use of oral chelators has shown some efficacy in those with chronic allergic contact dermatitis to nickel. […] The first approach to management of allergic contact dermatitis to nickel is to avoid products containing nickel. […] One can use cool compresses to soothe the symptoms. […] Nickel chelator creams, such as disodium ethylenediamine tetra-acetate or diethylenetriaminepentaacetic, can be applied to help chelate the positive ions released by the nickel. […] Lesions can be treated with mid- to high-potency topical steroids, such as triamcinolone 0.5% or clobetasol 0.05% cream, twice daily for 2-4 weeks. […] If the dermatitis involves greater than 20% body surface area, eyelid swelling, significant hand and foot involvement, or if it is severe, systemic steroid therapy can be required.

• #30 New cream blocks nickel allergy | News | Chemistry World

  https://www.chemistryworld.com/news/new-cream-blocks-nickel-allergy/3002806.article

  Researchers in the US claim to have made a cream to combat nickel allergy. The treatment uses nanoparticles to trap nickel on the skin of mice before it is absorbed- but there is some doubt whether it will work equally well with humans. […] Unfortunately, there is no cure for nickel allergy and although there are creams that relieve itching or act as a barrier against the metal, few of these are effective. […] Now, Jeffrey Karp and colleagues at the Harvard Medical School in Boston, Massachusetts, have developed what they claim is an effective approach to reduce nickel allergic reactions. […] Researchers say their technology could lead to a commercial cream in one or two years. […] Karp is keen to move ahead. We’re looking for industrial partners to work with to further develop and formulate the nanoparticles into creams, says Karp, adding: Creams could be available in one to two years.

• #31 A Novel DC Therapy with Manipulation of MKK6 Gene on Nickel Allergy in Mice | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019017

  DC activation by Ni played an important role in the development of Ni allergy. Manipulating the MKK6 gene in DCs may be a good therapeutic strategy for dermal Ni allergy. […] We next tested a therapeutic strategy for Ni allergy using short interfering (si) RNA targeting the MKK6 gene. […] Ear thickness of MKK6 siRNA-treated allergy model mice was significantly reduced compared with those of control siRNA-treated mice. […] This showed that an effective therapy using siRNA targeting the MKK6 gene could be used for treating Ni allergy.

• #32 Semaphorin 3A: A potential target for prevention and treatment of nickel allergy | Communications Biology

  https://www.nature.com/articles/s42003-022-03641-0

  Sema3A promotes the development of metal allergy and should be explored as a potential target for the prevention and treatment of metal allergy. […] Sema3A, being a secretory protein, might function like cytokines or chemokines and may play a crucial role in both intercellular and intracellular communication, thereby influencing the process of metal allergy development. Furthermore, it might be a potential target for the investigation and treatment of metal allergy. […] Sema3A may play a role in triggering or regulating the process of Ni allergy through p38 kinase activation and TNF- expression in keratinocytes. […] Sema3A in keratinocytes probably promotes the development of Ni allergy by altering ear swelling and the production of inflammatory and anti-inflammatory cytokines. […] It is conceivable that Sema3A has the potential to be further developed to provide new ideas and therapeutic targets for metal allergy.

• #33 Nickel Allergy – Causes, Symptoms and Treatment

  https://www.iafaforallergy.com/allergies-a-to-z/nickel-allergy/

  Dr. Guptas IAFA is Worlds 1st Ayurvedic institute that provide ayurvedic treatment of all types of allergies including Nickel allergy. […] Dr. Guptas IAFA is a one-stop solution for the management of all types of allergies including nickel allergy. Institute of Applied Food Allergy has successfully treated many patients suffering from different health conditions by implementing Ayurvedic concepts and management approaches. […] Ayurvedic medicines can successfully treat the conditions through internal medicines, external applications, detoxification therapies, and diet and lifestyle modifications. […] Nickel allergy rash treatment involves a multifaceted approach that includes internal medication, external applications, detoxification therapies, and diet and lifestyle modification. […] Natural and Ayurvedic treatment of nickel allergy can be done based on doshas predominance. The first line of treatment is Nidanaparivarjanam that means to avoid the exposure to allergens.

• #34 Nickel Allergy – Causes, Symptoms and Treatment

  https://www.iafaforallergy.com/allergies-a-to-z/nickel-allergy/

  Natural remedies for nickel allergy include the following:- Haridrakhandam, Guduchyadi Kasaya, Kaishor Guggulu, Gandhak Rasayan, Chitrakadi Vati. […] Herbal remedies for nickel allergy include the application of following herbal preparations: Eladitaila, Dineshavalyadi Thailam. […] Natural Treatment of nickel allergy includes the following detoxification therapies: Nasya (Nasal medication therapy), Rakta Moksha (Bloodletting). […] Home remedies for nickel allergy can be incorporated using the following single herbs: Brahmi (Bacopa Monnieri), Neem (Azadirachta Indica), Haridra (Curcuma longa), Guduchi (Tinospora Cordifolia). […] IAFA is one of the leading institutes that provide management of all types of allergies including Nickel allergy.

• #35 Metal Hypersensitivity – Causes, Symptoms, Treatment, Diagnosis – MedBroadcast.com

  https://medbroadcast.com/condition/getcondition/metal-hypersensitivity

  Treatment of metal hypersensitivity is highly individualized, as the allergens and reactions can be very different from person to person. […] Skin hypersensitivities can often be resolved by avoiding the item that causes the reaction. If the dermatitis is more significant, the doctor can also prescribe corticosteroid creams and ointments to reduce the local inflammation. The doctor can also prescribe oral antihistamines to further reduce the allergic reaction. Oral corticosteroids can also be used, but they can cause problematic side effects. […] Systemic reactions are more difficult to resolve, as they are often caused by implants. Removal of the implant is sometimes considered when a non-metal replacement is available and may be used. For example, a plastic-based dental filling material may be used to replace a previous metal dental filling. However, if the allergy is caused by an artificial knee or hip, replacement with a non-metal option is rarely done due to the difficulty of replacement. For these situations, treatment usually involves both topical (surface-applied) and oral medications to reduce the allergic reaction. Due to the difficult nature of treating systemic metal allergies, doctors sometimes recommend a hypersensitivity test before an implant is chosen.

• #36 Endovascular Treatment of Cerebrovascular Lesions Using Nickel- or Nitinol-Containing Devices in Patients with Nickel Allergies | American Journal of Neuroradiology

  https://www.ajnr.org/content/44/8/939

  SUMMARY: Nickel is used in many cerebral endovascular treatment devices. However, nickel hypersensitivity is the most common metal allergy, and the relative risk of treatment in these patients is unknown. This retrospective analysis identified patients with nickel or metal allergies who underwent cerebral endovascular treatment with nickel-containing devices. Seven patients with nickel and/or other metal allergies underwent treatment with 9 nickel-containing devices. None experienced periprocedural complications. No patient received treatment with corticosteroids or antihistamines. At a mean clinical follow-up for all patients of 22.8 months (range, 10.5-38.0 months), no patients had symptoms attributable to nickel allergic reactions. The mean radiographic follow-up for all patients at 18.4 months (range, 2.5-37.5 months) showed successful treatment of the targeted vascular pathologies, with no evidence of in-stent stenosis or other allergic or hypersensitivity sequelae. The treatment of cerebrovascular lesions with a nickel-containing device resulted in no adverse outcomes among these patients and was safe and effective.

• #37 Endovascular Treatment of Cerebrovascular Lesions Using Nickel- or Nitinol-Containing Devices in Patients with Nickel Allergies | American Journal of Neuroradiology

  https://www.ajnr.org/content/44/8/939

  In this study, we sought to review the perioperative management and outcomes of patients with documented nickel and other metal allergies who underwent endovascular cerebrovascular pathology treatment with nickel-containing devices. […] Seven patients (mean age, 61.7 years; range, 40s-80s) with documented nickel allergies (4 patients) or other metal allergies (3 patients) who had 9 vascular lesions (7 saccular aneurysms, 1 blister or fusiform aneurysm, and 1 intracranial dissection) underwent treatment with a total of 9 nickel-containing devices (7 flow-diverting stents and 2 self-expanding intracranial stents) during 8 treatment sessions. […] No patient experienced any periprocedural complications, including any apparent allergic reactions, thromboembolic events, or in-stent stenoses.

• #38 Metallic allergy requiring removal of iliac stent: report of a case | Surgical Case Reports | Full Text

  https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-020-00843-8

  The use of metallic stents, which are predominantly composed of nickel, in the treatment of patients with nickel allergy has not been well studied. […] A patient who suffered from contact dermatitis due to implantation of an iliac stent was successfully treated by removing the stent that caused nickel allergy. […] In cases of suspected metallic allergy, it is necessary to consider revascularization without using a metal device. […] We successfully treated a patient with nickel allergy by removing a metallic stent from the patients iliac artery. […] Since the administration of steroids did not improve the symptoms, it was determined that the removal of the allergen was appropriate. […] Postoperatively, her dermatitis significantly improved, and her depression disappeared immediately.

• #39 Nickel allergy: Symptoms, treatment, and what to avoid

  https://www.medicalnewstoday.com/articles/321400

  There is no cure for an allergy to nickel. The best way to prevent a reaction is to avoid the allergen. […] Several medications can help to treat a rash that results from an allergic reaction. These medicines control inflammation and reduce the body’s histamine response. […] Common medications include: corticosteroid creams, nonsteroidal creams, oral corticosteroids, such as prednisone, oral antihistamines, such as fexofenadine. […] Antihistamines are available over the counter and can be bought online. Mild-strength corticosteroid creams are also available online. A doctor may prescribe stronger versions of these medications. […] Some home remedies may help to soothe and calm the skin. These include: calamine lotion, hydrating body lotion, cool, wet compresses. […] Seek advice from a doctor as soon as possible if treatments do not relieve symptoms or make them worse. […] If reactions to nickel are severe, see a doctor as soon as possible. Severe symptoms may include pain or blisters that leak pus, and they can indicate an infection that requires treatment with antibiotics.

• #40 What You Should Know About Nickel Allergies | Banner Health

  https://www.bannerhealth.com/healthcareblog/teach-me/is-a-nickel-allergy-making-your-skin-itchy-and-red

  Most of the time, once you identify a nickel allergy, you can avoid contact with things that contain nickel and eliminate the possibility of an allergic reaction. […] If the allergic reaction is irritating your skin, you can apply a hypoallergenic lotion to calm itching and soothe discomfort. […] If you have a severe rash, intense itching or blistering, or if your rash doesn’t go away after you’ve removed the object that contains nickel, see your primary care provider. Your provider can evaluate whether you have a nickel allergy or something else that’s causing your rash. And they can consider whether you need a steroid cream or other treatment. […] If you’re allergic to nickel, your best option is to avoid wearing things that contain nickel or to put a barrier between your skin and the nickel.

• #41 Nickel (Jewelry) Allergies: Symptoms, Treatments, and Avoid Triggers

  https://www.webmd.com/allergies/nickel-jewelry-allergy

  Your doctor can often diagnose a nickel allergy by looking at your skin and asking if you’ve touched anything metal. […] A dermatologist also can give you a skin patch test. They’ll put tiny amounts of nickel and other allergens on the skin of your upper back and covers them with patches. The patches must stay on for 48 hours. If you’re allergic to nickel, your skin will likely show a reaction after that amount of time. In some cases, you’ll need more tests. […] Once a nickel allergy develops, it often lasts your whole life. But there are ways to ease your symptoms. […] The most important thing you can do is avoid contact with objects that can cause a reaction. For mild symptoms, an over-the-counter hydrocortisone cream and antihistamines may help. […] For more severe symptoms, your doctor may prescribe a steroid cream or a drug that works on your immune system. If your symptoms are very severe, your treatment may also include steroids that you take by mouth and antihistamine pills. […] If your skin is cracked or blistered, you should take off any metal jewelry right away and see your doctor for treatment to avoid getting an infection.

• #42 Nickel Allergy: What To Look For (And Avoid) – Eternal Dermatology & Aesthetic Center

  https://www.eternaldermatology.com/nickel-allergy-what-to-look-for-and-avoid/

  Once the immune system decides that nickel is harmful, you will always have a nickel allergy. That means anytime you come into contact with nickel, either through friction on your skin or ingested, you’ll have a flare-up. Unfortunately, there is no cure. What you can do is take some precautions and treatment to reduce the symptoms of ACD. […] Your first step is to see a dermatologist immediately. At Eternal Dermatology, we are the premier facility for treating a nickel allergy in Columbia, MD, Howard County, and the DC Baltimore area. If you aren’t in the area, search nickel allergy near me or contact dermatitis near me for a list of dermatologists in your area who can help. […] If your nickel allergy or rash is still present at this point, we can prescribe medication to help treat the inflammation and symptoms. If the nickel allergy affects a large part of your body, for example, in cases where it’s ingested, you may need oral steroids. Make sure to take the medication as directed to avoid any unwanted side effects. Your dermatologist may request a follow-up visit to check on your progress or prescribe more medication. While medical treatment helps, there are some steps you should take to avoid or prevent the allergy.

• #43 Nickel Allergy: Symptoms, Treatment & How to Protect Yourself

  https://eczemaless.com/nickel-allergy-symptoms-treatment-how-to-protect-yourself/

  Nickel allergy can be challenging to manage due to the prevalence of nickel in everyday items. However, with some proactive measures, you can significantly reduce your risk of exposure and manage your symptoms effectively. […] Living with a nickel allergy requires vigilance and proactive management. Here are some additional tips to help you navigate daily life: […] Regular Dermatologist Visits: Schedule regular check-ups with your dermatologist to monitor your condition and adjust treatment as needed. […] By understanding the causes, recognizing the symptoms, and implementing effective treatments and preventive measures, you can lead a comfortable and healthy life despite your nickel allergy.

Zobacz więcej