Selektywna niedobór iga – Charakterystyka, pielęgnacja i opieka

Selektywna niedobór iga
Charakterystyka, pielęgnacja i opieka

Selektywny niedobór IgA to najczęstszy pierwotny niedobór odporności, definiowany jako poziom IgA <7 mg/dl przy prawidłowych stężeniach pozostałych immunoglobulin (IgG, IgM). IgA pełni kluczową rolę w ochronie błon śluzowych układu oddechowego, pokarmowego i jamy ustnej. U 85-90% pacjentów przebiega bezobjawowo, natomiast u pozostałych obserwuje się nawracające infekcje (np. zapalenie płuc, zatok, ucha), choroby autoimmunologiczne i alergie. Diagnostyka opiera się na badaniu poziomu IgA i wykluczeniu innych niedoborów immunoglobulin. Pacjenci z niedoborem IgA mają 10-20-krotnie zwiększone ryzyko rozwoju choroby trzewnej, co wymaga stosowania testów przeciwciał IgG-tTG zamiast IgA-tTG. Leczenie jest objawowe, obejmuje antybiotykoterapię (w tym profilaktyczną) oraz szczepienia zgodne z zaleceniami CDC (m.in. przeciw pneumokokom, Hib, grypie i półpaścowi).

Selektywny niedobór IgA – podstawy opieki medycznej

Selektywny niedobór IgA jest najczęstszym pierwotnym niedoborem odporności, charakteryzującym się niskim lub niewykrywalnym poziomem immunoglobuliny A we krwi przy prawidłowych poziomach pozostałych immunoglobulin (IgG, IgM, IgD, IgE). ¹² Osobę uznaje się za dotkniętą niedoborem IgA, gdy poziom IgA we krwi wynosi poniżej 7 mg/dl przy normalnych poziomach IgG i IgM. ³ IgA odgrywa kluczową rolę w ochronie błon śluzowych jamy ustnej, dróg oddechowych i przewodu pokarmowego przed infekcjami. ⁴

Około 85-90% pacjentów z selektywnym niedoborem IgA nie wykazuje objawów. ⁵ U pozostałych pacjentów występują częste infekcje, choroby autoimmunologiczne lub alergie. ⁶ Najczęstsze objawy to podatność na infekcje, w tym zapalenie płuc, zapalenie zatok, infekcje ucha oraz przewlekła biegunka spowodowana infekcjami przewodu pokarmowego. ⁷

Diagnostyka i znaczenie kliniczne

Diagnostyka selektywnego niedoboru IgA wymaga badania krwi wykazującego niedobór IgA przy prawidłowych poziomach innych immunoglobulin. ⁸ Istotne jest, aby pacjenci z obniżonym poziomem IgA zostali skierowani do alergologa/immunologa, szczególnie w przypadku nawracających infekcji układu oddechowego, zakażeń Giardia, choroby trzewnej, rodzinnego wywiadu niedoboru IgA lub reakcji anafilaktycznej na transfuzję krwi. ⁹

Pacjenci z selektywnym niedoborem IgA mają 10-20 razy wyższe ryzyko rozwoju choroby trzewnej w porównaniu z populacją ogólną. ¹⁰ W przypadku podejrzenia choroby trzewnej u osób z niedoborem IgA, należy zastosować test przeciwciał IgG-tTG zamiast IgA-tTG, ponieważ ten drugi nie będzie wiarygodny. ¹¹

Podejście terapeutyczne w selektywnym niedoborze IgA

Nie istnieje leczenie specyficzne dla selektywnego niedoboru IgA. ¹²¹³ U niektórych pacjentów z czasem może dojść do spontanicznej normalizacji poziomów IgA. ¹⁴ Osoby bez objawów nie wymagają żadnej terapii, jednak istotna jest edukacja i świadomość stanu zdrowia. ¹⁵

Leczenie koncentruje się na łagodzeniu objawów, zapobieganiu i leczeniu infekcji oraz kontrolowaniu chorób współistniejących. ¹⁶ Podstawowe elementy postępowania terapeutycznego obejmują:

Antybiotykoterapia

Antybiotyki stosuje się do leczenia infekcji bakteryjnych. ¹⁷¹⁸ Pacjenci z selektywnym niedoborem IgA często wymagają dłuższego kursu antybiotyków, aby całkowicie wyleczyć infekcję. ¹⁹ W przypadku nawracających lub przewlekłych infekcji, takich jak przewlekłe zapalenie oskrzeli, stosuje się antybiotyki profilaktycznie, co określa się jako profilaktykę antybiotykową. ²⁰²¹

Pacjenci z istotnie nawracającymi infekcjami górnych dróg oddechowych mogą odnieść korzyść z 6-miesięcznego kursu antybiotyków profilaktycznych. Leczenie to można kontynuować, jeśli początkowy kurs okaże się skuteczny. ²² U niektórych pacjentów antybiotyki profilaktyczne mogą być stosowane w sposób ciągły lub przerywany. ²³

Szczepienia ochronne

Wszystkie dzieci z selektywnym niedoborem IgA powinny być szczepione zgodnie z tym samym harmonogramem, co dzieci bez niedoboru, oraz powinny otrzymywać coroczną szczepionkę przeciwko grypie. ²⁴ Według CDC, pacjentom z niedoborem IgA zaleca się szczepionki przeciwko pneumokokom, Hib (dla dzieci w wieku 12-59 miesięcy) oraz szczepionkę przeciwko półpaścowi ze względu na szczególne ryzyko infekcji. ²⁵

Terapia immunoglobulinami

W przeciwieństwie do wielu innych niedoborów immunoglobulin, selektywny niedobór IgA nie jest leczony rutynowo terapią substytucyjną immunoglobulinami. ²⁶ Jednak niewielka grupa pacjentów, u których mimo profilaktyki antybiotykowej nadal występują nawracające infekcje, może kwalifikować się do leczenia substytucyjnego immunoglobulinami, choć zastosowanie tej terapii pozostaje kontrowersyjne. ²⁷

Producenci preparatów IVIG (dożylne immunoglobuliny) zaznaczają na etykietach, że produkty te nie powinny być stosowane u osób z niedoborem IgA, które mają przeciwciała anty-IgA. Jednakże, badania sugerują, że przeciwciała anty-IgA mogą nie być tak istotne w wywoływaniu działań niepożądanych, jak wcześniej sądzono. ²⁸

Podskórne immunoglobuliny (SCIG) lub preparaty IVIG z niską zawartością IgA są uznawane za optymalne dla osób z niedoborem IgA, ponieważ niosą mniejsze ryzyko poważnych działań niepożądanych. ²⁹ Przegląd z 2017 roku wykazał, że stosowanie SCIG lub IVIG w niedoborze IgA jest zazwyczaj bezpieczne. ³⁰

Przy stosowaniu IVIG u pacjentów z niedoborem IgA najlepiej jest:

Stosować produkt z niską zawartością IgA
Przejść na SCIG, jeśli IVIG powoduje znaczące problemy
Stosować premedykację przed IVIG w celu przeciwdziałania możliwym reakcjom
Zachować ostrożność podczas i po leczeniu ³¹

Leczenie chorób współistniejących

Niedobór IgA może zwiększać ryzyko rozwoju innych chorób związanych z układem immunologicznym, takich jak alergie, astma, reumatoidalne zapalenie stawów, choroby zapalne jelit i inne. ³² Pacjenci mają również wyższe ryzyko wystąpienia cukrzycy typu 1, tocznia, młodzieńczego idiopatycznego zapalenia stawów oraz chorób tarczycy. ³³

Leczenie chorób autoimmunologicznych może obejmować systemowe kortykosteroidy i inne leki przeciwzapalne lub leki biologiczne (w tym przeciwciała monoklonalne). W przypadku zajęcia układu endokrynologicznego może być stosowana terapia hormonalna zastępcza. ³⁴

Konieczne mogą być również modyfikacje dietetyczne w celu zarządzania przewlekłą biegunką, zespołami złego wchłaniania lub alergią pokarmową u pacjentów z niedoborem IgA. ³⁵

Bezpieczeństwo transfuzji i preparatów krwiopochodnych

Osoby z selektywnym niedoborem IgA mogą wytworzyć przeciwciała anty-IgA, powodujące reakcje alergiczne podczas transfuzji produktów krwiopochodnych zawierających IgA. ³⁶ Pacjenci ci są znacznie bardziej narażeni na reakcje potransfuzyjne w porównaniu z populacją ogólną, co wymaga starannego doboru produktów krwiopochodnych w celu zapobiegania powikłaniom. ³⁷

Postępowanie przed transfuzją

Zaleca się badanie przesiewowe pacjentów z ciężkim selektywnym niedoborem IgA oraz tych, którzy wcześniej doświadczyli reakcji na produkty krwiopochodne, w kierunku obecności przeciwciał anty-IgA. ³⁸ Klinicyści muszą wdrożyć plan bezpiecznego podawania produktów krwiopochodnych u pacjentów z dodatnim wynikiem testu na przeciwciała. ³⁹

Osoby z selektywnym niedoborem IgA powinny nosić identyfikator medyczny, który informuje personel medyczny o ich stanie, potencjalnym ryzyku reakcji anafilaktycznej na produkty krwiopochodne zawierające osocze oraz o konieczności wykonania testu na przeciwciała anty-IgA przed transfuzją. ⁴⁰ Zaleca się również noszenie bransoletki medycznej informującej, że pacjent ma selektywny niedobór IgA i powinien otrzymywać zmodyfikowaną krew lub produkty krwiopochodne. ⁴¹

Metody zapobiegania reakcjom anafilaktycznym

Metody zapobiegania reakcjom anafilaktycznym u pacjentów z przeciwciałami anty-IgA obejmują:

Wyłączne stosowanie produktów od dawców z niedoborem IgA
Transfuzję przemytych płytek krwi i czerwonych krwinek ⁴²
Stosowanie osocza od dawcy z niedoborem IgA, ponieważ osocza nie można przemyć ⁴³

Jeśli pacjent z selektywnym niedoborem IgA wymaga transfuzji lub podania preparatów immunoglobulinowych, należy koniecznie poinformować o tym lekarza, aby mógł otrzymać zmodyfikowane produkty krwiopochodne. ⁴⁴⁴⁵

Opieka długoterminowa i monitorowanie

Większość pacjentów z selektywnym niedoborem IgA ma niepowikłany przebieg kliniczny. ⁴⁶ Jednakże wymagane jest długoterminowe monitorowanie w celu identyfikacji innych nieprawidłowości immunologicznych, takich jak pospolity zmienny niedobór odporności (CVID), choroby autoimmunologiczne i nowotwory. ⁴⁷

Pacjenci powinni regularnie odbywać wizyty kontrolne kliniczne i immunologiczne po zdiagnozowaniu niedoboru IgA. ⁴⁸ Dzieci z niedoborem IgA mogą z czasem odzyskać prawidłowe poziomy immunoglobuliny. ⁴⁹

Osoby z selektywnym niedoborem IgA powinny skontaktować się z lekarzem, jeśli występują u nich objawy infekcji lub objawy jelitowe. ⁵⁰⁵¹ Poradnictwo genetyczne może być wartościowe dla przyszłych rodziców z rodzinnym wywiadem selektywnego niedoboru IgA. ⁵²⁵³

Edukacja i wsparcie pacjenta

Zwiększanie świadomości i zachęcanie do proaktywnego zarządzania może pomóc w zapobieganiu zagrażającym życiu reakcjom transfuzyjnym i umożliwić pacjentom aktywny udział w opiece zdrowotnej. ⁵⁴ Większość osób z łagodnym niedoborem IgA, które nie wykazują objawów, nie musi podejmować specjalnych środków ostrożności, ale powinna zostać poddana ocenie przez certyfikowanego alergologa/immunologa, aby ustalić, czy konieczne są specjalne środki ostrożności przy transfuzjach krwi. ⁵⁵

Osoby, które doświadczyły reakcji anafilaktycznej na transfuzję krwi lub immunoglobuliny, powinny nosić identyfikator medyczny, aby ostrzec lekarzy o konieczności zachowania środków ostrożności przeciwko takim reakcjom. ⁵⁶

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Materiały źródłowe

#1 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Selective IgA deficiency is the most common primary immunodeficiency disease (PIDD). People with this disorder have absent levels of a blood protein called immunoglobulin A (IgA). IgA protects against infections of the mucous membranes lining the mouth, airways and digestive tract. […] A common problem in IgA deficiency is susceptibility to infections. A second major problem in IgA deficiency is increased occurrence of autoimmune diseases. Also, many people with Selective IgA Deficiency also have allergies or asthma. […] The most common symptom of Selective IgA Deficiency is susceptibility to infections including: Pneumonia, Sinusitis, Ear infections, Chronic diarrhea caused by gastrointestinal infections. […] Diagnosis requires blood screening to show an IgA deficiency but normal levels of other immunoglobulins.
#2 Low IgA & Selective IgA Deficiency: Causes & Symptoms – SelfDecode Labs
https://labs.selfdecode.com/blog/iga-deficiency/
Low IgA can be caused by selective IgA deficiency, when only IgA levels are low but other antibodies (IgG, IgM, IgD, and IgE) are normal. […] Selective IgA deficiency can be inherited or occur spontaneously (due to infections, medication, or unknown causes). […] People are IgA deficient if they have blood IgA levels below 7 mg/dL with normal IgM and IgG levels. […] Eighty-five to 90% of people with IgA deficiency have no symptoms. Those with symptoms usually have respiratory or gut infections. […] IgA-deficient people have a tendency to develop infections and disorders of the gut, such as malabsorption, lactose intolerance, celiac disease, and ulcerative colitis. […] Patients with selective IgA deficiency (undetectable IgA but normal IgG and IgM levels) have a 10 to 20 times higher risk of celiac disease.
#3 Low IgA & Selective IgA Deficiency: Causes & Symptoms – SelfDecode Labs
https://labs.selfdecode.com/blog/iga-deficiency/
Low IgA can be caused by selective IgA deficiency, when only IgA levels are low but other antibodies (IgG, IgM, IgD, and IgE) are normal. […] Selective IgA deficiency can be inherited or occur spontaneously (due to infections, medication, or unknown causes). […] People are IgA deficient if they have blood IgA levels below 7 mg/dL with normal IgM and IgG levels. […] Eighty-five to 90% of people with IgA deficiency have no symptoms. Those with symptoms usually have respiratory or gut infections. […] IgA-deficient people have a tendency to develop infections and disorders of the gut, such as malabsorption, lactose intolerance, celiac disease, and ulcerative colitis. […] Patients with selective IgA deficiency (undetectable IgA but normal IgG and IgM levels) have a 10 to 20 times higher risk of celiac disease.
#4 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Selective IgA deficiency is the most common primary immunodeficiency disease (PIDD). People with this disorder have absent levels of a blood protein called immunoglobulin A (IgA). IgA protects against infections of the mucous membranes lining the mouth, airways and digestive tract. […] A common problem in IgA deficiency is susceptibility to infections. A second major problem in IgA deficiency is increased occurrence of autoimmune diseases. Also, many people with Selective IgA Deficiency also have allergies or asthma. […] The most common symptom of Selective IgA Deficiency is susceptibility to infections including: Pneumonia, Sinusitis, Ear infections, Chronic diarrhea caused by gastrointestinal infections. […] Diagnosis requires blood screening to show an IgA deficiency but normal levels of other immunoglobulins.
#5 Low IgA & Selective IgA Deficiency: Causes & Symptoms – SelfDecode Labs
https://labs.selfdecode.com/blog/iga-deficiency/
Low IgA can be caused by selective IgA deficiency, when only IgA levels are low but other antibodies (IgG, IgM, IgD, and IgE) are normal. […] Selective IgA deficiency can be inherited or occur spontaneously (due to infections, medication, or unknown causes). […] People are IgA deficient if they have blood IgA levels below 7 mg/dL with normal IgM and IgG levels. […] Eighty-five to 90% of people with IgA deficiency have no symptoms. Those with symptoms usually have respiratory or gut infections. […] IgA-deficient people have a tendency to develop infections and disorders of the gut, such as malabsorption, lactose intolerance, celiac disease, and ulcerative colitis. […] Patients with selective IgA deficiency (undetectable IgA but normal IgG and IgM levels) have a 10 to 20 times higher risk of celiac disease.
#6 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Selective IgA deficiency is the most common primary immunodeficiency disease (PIDD). People with this disorder have absent levels of a blood protein called immunoglobulin A (IgA). IgA protects against infections of the mucous membranes lining the mouth, airways and digestive tract. […] A common problem in IgA deficiency is susceptibility to infections. A second major problem in IgA deficiency is increased occurrence of autoimmune diseases. Also, many people with Selective IgA Deficiency also have allergies or asthma. […] The most common symptom of Selective IgA Deficiency is susceptibility to infections including: Pneumonia, Sinusitis, Ear infections, Chronic diarrhea caused by gastrointestinal infections. […] Diagnosis requires blood screening to show an IgA deficiency but normal levels of other immunoglobulins.
#7 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Selective IgA deficiency is the most common primary immunodeficiency disease (PIDD). People with this disorder have absent levels of a blood protein called immunoglobulin A (IgA). IgA protects against infections of the mucous membranes lining the mouth, airways and digestive tract. […] A common problem in IgA deficiency is susceptibility to infections. A second major problem in IgA deficiency is increased occurrence of autoimmune diseases. Also, many people with Selective IgA Deficiency also have allergies or asthma. […] The most common symptom of Selective IgA Deficiency is susceptibility to infections including: Pneumonia, Sinusitis, Ear infections, Chronic diarrhea caused by gastrointestinal infections. […] Diagnosis requires blood screening to show an IgA deficiency but normal levels of other immunoglobulins.
#8 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Selective IgA deficiency is the most common primary immunodeficiency disease (PIDD). People with this disorder have absent levels of a blood protein called immunoglobulin A (IgA). IgA protects against infections of the mucous membranes lining the mouth, airways and digestive tract. […] A common problem in IgA deficiency is susceptibility to infections. A second major problem in IgA deficiency is increased occurrence of autoimmune diseases. Also, many people with Selective IgA Deficiency also have allergies or asthma. […] The most common symptom of Selective IgA Deficiency is susceptibility to infections including: Pneumonia, Sinusitis, Ear infections, Chronic diarrhea caused by gastrointestinal infections. […] Diagnosis requires blood screening to show an IgA deficiency but normal levels of other immunoglobulins.
#9
https://www.nicklauschildrens.org/symptoms/iga-deficiency
Immunoglobulin A, or IgA, is an antibody that is found primarily within the tissues of the body. […] A majority of patients with IgA deficiency are asymptomatic, and do not need to take specific precautions. You should be evaluated by a board certified Allergist/Immunologist to determine if you need to take special precautions with blood transfusions. […] You should see a board certified Allergist/Immunologist if you have been found to have low or absent IgA on blood work, if you have recurrent sinopulmonary infections, giardia infection, celiac disease, family history of IgA deficiency, or an anaphylactic reaction to a blood transfusion.
#10 IgA Deficiency and Celiac Disease | BeyondCeliac.org
https://www.beyondceliac.org/celiac-disease/related-conditions/iga-deficiency/
People with IgA deficiency should be tested for celiac disease because they are 10 to 20 times likely to develop an autoimmune response to gluten than the general population; […] Those with IgA deficiency should be tested for IgG-tTG antibodies instead of IgA-tTG. This is because the IgA-tTG test will not be accurate in those with IgA deficiency.
#11 IgA Deficiency and Celiac Disease | BeyondCeliac.org
https://www.beyondceliac.org/celiac-disease/related-conditions/iga-deficiency/
People with IgA deficiency should be tested for celiac disease because they are 10 to 20 times likely to develop an autoimmune response to gluten than the general population; […] Those with IgA deficiency should be tested for IgG-tTG antibodies instead of IgA-tTG. This is because the IgA-tTG test will not be accurate in those with IgA deficiency.
#12 Selective IgA deficiency | Health Library | Memorial Health System
https://www.mhsystem.org/health-library/con-20256724/
Selective IgA deficiency may increase the risk of other conditions related to the immune system, such as allergies, asthma, rheumatoid arthritis, inflammatory bowel diseases and others. […] There is no treatment specifically for selective IgA deficiency. Treatments focus on addressing the frequent, repeat or long-lasting conditions that develop with this immune system disorder. […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis). […] Healthcare professionals recommend wearing a medical bracelet. A bracelet can show that you have selective IgA deficiency and should receive modified blood or blood products.
#13 Selective deficiency of IgA: MedlinePlus Medical EncyclopediaLock
https://medlineplus.gov/ency/article/001476.htm
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#14 Selective deficiency of IgA: MedlinePlus Medical EncyclopediaLock
https://medlineplus.gov/ency/article/001476.htm
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#15 Selective IgA Deficiency : Symptoms, Causes and Treatment
https://www.apollohospitals.com/diseases-and-conditions/selective-iga-deficiency-symptoms-causes-and-treatment/
Those who are IgA-deficient but do not exhibit any symptoms do not need therapy. […] It is nevertheless essential to provide awareness and education. Medical alert bracelets should be recommended for patients with selective IgA deficiency. […] The backbone of treatment for IgA deficiency is the treatment of associated diseases. Patients who suffer from recurring infections may benefit from prophylactic antibiotics continuously or on an intermittent basis. […] Generally, SIgAD patients do well unless they have significant comorbid diseases. Children with IgA deficiency can recover over time. The patient, however, should go for regular clinical and immunological follow-up after being diagnosed with IgA deficiency.
#16 Selective IgA deficiency | Health Library | Memorial Health System
https://www.mhsystem.org/health-library/con-20256724/
Selective IgA deficiency may increase the risk of other conditions related to the immune system, such as allergies, asthma, rheumatoid arthritis, inflammatory bowel diseases and others. […] There is no treatment specifically for selective IgA deficiency. Treatments focus on addressing the frequent, repeat or long-lasting conditions that develop with this immune system disorder. […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis). […] Healthcare professionals recommend wearing a medical bracelet. A bracelet can show that you have selective IgA deficiency and should receive modified blood or blood products.
#17 Selective IgA deficiency – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/selective-iga-deficiency/diagnosis-treatment/drc-20450490
Our caring team of Mayo Clinic experts can help you with your Selective IgA deficiency-related health concerns […] Selective IgA deficiency care at Mayo Clinic […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis).
#18 Selective Immunoglobulin A (IgA) Deficiency – Immune Disorders – MSD Manual Consumer Version
https://www.msdmanuals.com/home/immune-disorders/immunodeficiency-disorders/selective-immunoglobulin-a-iga-deficiency
Most people with selective IgA deficiency have few or no symptoms, but some have chronic lung infections, sinusitis, and other disorders. […] Antibiotics are used to treat or sometimes to prevent infections. […] Usually, no treatment of selective IgA deficiency is needed. […] Antibiotics are given to people who have an infection. If the disorder is severe, antibiotics are given in advance to prevent infections from developing. […] People who have had an anaphylactic reaction to a blood transfusion or immune globulin should wear medical identification to alert doctors to take precautions against such reactions.
#19 IgA Deficiency and Celiac Disease | BeyondCeliac.org
https://www.beyondceliac.org/celiac-disease/related-conditions/iga-deficiency/
Selective immunoglobulin A (IgA) deficiency is a genetic immunodeficiency condition in which individuals do not make or have very low blood levels of IgA antibodies. IgA antibodies are responsible for fighting infections in mucus membranes throughout the body. These antibodies are important as they play a major role in mucosal surface health. Some with IgA deficiency find themselves with recurrent infections in places such as the ears, sinuses or urinary and intestinal tracts. Additionally, some with selective IgA deficiency may not only suffer from recurrent infections but may take longer to heal from them or need additional rounds of antibiotics to fend off an infection. […] It is currently not possible to replace IgA in a person with an IgA deficiency, so treatment focuses on alleviating specific symptoms (such as using antibiotics for infections) and treating the underlying issue itself.
#20 Selective IgA deficiency – Diagnosis and treatment – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/selective-iga-deficiency/diagnosis-treatment/drc-20450490
Our caring team of Mayo Clinic experts can help you with your Selective IgA deficiency-related health concerns […] Selective IgA deficiency care at Mayo Clinic […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis).
#21 Selective Immunoglobulin A (IgA) Deficiency – Immune Disorders – MSD Manual Consumer Version
https://www.msdmanuals.com/home/immune-disorders/immunodeficiency-disorders/selective-immunoglobulin-a-iga-deficiency
Most people with selective IgA deficiency have few or no symptoms, but some have chronic lung infections, sinusitis, and other disorders. […] Antibiotics are used to treat or sometimes to prevent infections. […] Usually, no treatment of selective IgA deficiency is needed. […] Antibiotics are given to people who have an infection. If the disorder is severe, antibiotics are given in advance to prevent infections from developing. […] People who have had an anaphylactic reaction to a blood transfusion or immune globulin should wear medical identification to alert doctors to take precautions against such reactions.
#22 Selective IgA Deficiency in Children: Clinical Manifestations, Evaluation, and Management
https://www.contemporarypediatrics.com/view/selective-iga-deficiency-children-clinical-manifestations-evaluation-and-management
Selective IgA deficiency (SIGAD) is the most common immunodeficiency disorder; it affects about 1 in 200 to 900 persons. Most affected children are asymptomatic. […] Patients with SIGAD who have significant recurrent upper respiratory tract infections may benefit from a 6-month course of prophylactic antibiotics. These antibiotics may be continued if the initial course is successful. […] A small number of patients with SIGAD continue to have recurrent infections despite antibiotic prophylaxis. These patients may be treated with immunoglobulin replacement therapy; however, use of this treatment remains controversial. […] All children with SIGAD should be immunized according to the same schedule used for children without SIGAD and should receive the annual influenza vaccine. Most patients with SIGAD have an uncomplicated clinical course. However, continued long-term follow-up to identify other immunological abnormalities, such as CVID, autoimmune disease, and malignancy, is required.
#23 Selective IgA Deficiency : Symptoms, Causes and Treatment
https://www.apollohospitals.com/diseases-and-conditions/selective-iga-deficiency-symptoms-causes-and-treatment/
Those who are IgA-deficient but do not exhibit any symptoms do not need therapy. […] It is nevertheless essential to provide awareness and education. Medical alert bracelets should be recommended for patients with selective IgA deficiency. […] The backbone of treatment for IgA deficiency is the treatment of associated diseases. Patients who suffer from recurring infections may benefit from prophylactic antibiotics continuously or on an intermittent basis. […] Generally, SIgAD patients do well unless they have significant comorbid diseases. Children with IgA deficiency can recover over time. The patient, however, should go for regular clinical and immunological follow-up after being diagnosed with IgA deficiency.
#24 Selective IgA Deficiency in Children: Clinical Manifestations, Evaluation, and Management
https://www.contemporarypediatrics.com/view/selective-iga-deficiency-children-clinical-manifestations-evaluation-and-management
Selective IgA deficiency (SIGAD) is the most common immunodeficiency disorder; it affects about 1 in 200 to 900 persons. Most affected children are asymptomatic. […] Patients with SIGAD who have significant recurrent upper respiratory tract infections may benefit from a 6-month course of prophylactic antibiotics. These antibiotics may be continued if the initial course is successful. […] A small number of patients with SIGAD continue to have recurrent infections despite antibiotic prophylaxis. These patients may be treated with immunoglobulin replacement therapy; however, use of this treatment remains controversial. […] All children with SIGAD should be immunized according to the same schedule used for children without SIGAD and should receive the annual influenza vaccine. Most patients with SIGAD have an uncomplicated clinical course. However, continued long-term follow-up to identify other immunological abnormalities, such as CVID, autoimmune disease, and malignancy, is required.
#25 Immunoglobulin A Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations
https://emedicine.medscape.com/article/136580-treatment
The approach to treatment of immunoglobulin A deficiency (IgAD) includes identification of comorbid conditions, preventive measures to reduce the risk of infection, and prompt, rigorous, and effective treatment of infections. […] Dietary modifications may be necessary to manage chronic diarrhea and malabsorption or food allergy in patients with immunoglobulin A deficiency (IgAD). […] A priori restrictions on activity are not necessary in immunoglobulin A deficiency (IgAD), but patients with chronic lung disease may have decreased exercise tolerance. […] Primary prevention for immunoglobulin A deficiency (IgAD) has not been developed. […] Secondary prevention relies primarily on vaccination to increase specific IgG and IgM. […] Tertiary prevention includes (1) prompt antibiotic treatment for respiratory tract infections, (2) microbial identification of diarrheal pathogens and specific treatment, (3) dietary modification for malabsorption syndromes, and (4) use of washed cells and/or IgA-poor blood if whole blood is needed, and screening for anti-IgA antibodies if reactions to blood products occur. […] Per the CDC, patients with IgAD are recommended to receive the pneumococcal Hib (for children aged 12-59 months) and recombinant zoster vaccines given their specific risks for infection.
#26 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Unlike many other immunoglobulin deficiencies, the condition is not treated with immunoglobulin replacement therapy. […] In cases where recurrent infections are a problem, preventative antibiotics may be used to help diminish the frequency of infections. Individuals with IgA deficiency often require a longer course of antibiotics for infections to clear up. Selective IgA deficiency can also predispose individuals to have allergic-like or anaphylactic reactions to blood transfusions or infusions of certain blood products. If you have an IgA deficiency, be certain to notify your healthcare provider so you receive modified blood products if necessary.
#27 Selective IgA Deficiency in Children: Clinical Manifestations, Evaluation, and Management
https://www.contemporarypediatrics.com/view/selective-iga-deficiency-children-clinical-manifestations-evaluation-and-management
Selective IgA deficiency (SIGAD) is the most common immunodeficiency disorder; it affects about 1 in 200 to 900 persons. Most affected children are asymptomatic. […] Patients with SIGAD who have significant recurrent upper respiratory tract infections may benefit from a 6-month course of prophylactic antibiotics. These antibiotics may be continued if the initial course is successful. […] A small number of patients with SIGAD continue to have recurrent infections despite antibiotic prophylaxis. These patients may be treated with immunoglobulin replacement therapy; however, use of this treatment remains controversial. […] All children with SIGAD should be immunized according to the same schedule used for children without SIGAD and should receive the annual influenza vaccine. Most patients with SIGAD have an uncomplicated clinical course. However, continued long-term follow-up to identify other immunological abnormalities, such as CVID, autoimmune disease, and malignancy, is required.
#28 Can You Use IVIG For IgA Deficiency? – AmeriPharmaÂ® Specialty Care
https://ameripharmaspecialty.com/ivig/can-you-use-ivig-for-iga-deficiency/
IVIG therapy is not the primary treatment for IgA deficiency. Nonetheless, it may be an option if vaccines and antibiotics donât work. […] The manufacturers of IVIG products mention on the label that these products shouldnât be used in IgA-deficient people with anti-IgA antibodies. Likewise, they state that because these preparations contain mostly IgG and tiny amounts of IgA, IgA-deficient people are unlikely to benefit from them. […] However, some studies suggest that anti-IgA antibodies may not be as crucial to causing side effects as previously thought. Similarly, IgA-containing products do not always trigger anti-IgA antibodies. Notably, there have been several studies showing the safe use of IVIG for IgA deficiency, even in people with high levels of anti-IgA antibodies. […] Subcutaneous IG (SCIG) or IVIG preparations with low amounts of IgA are ideal for IgA-deficient people, as they carry a lower risk of serious side effects. A 2017 review noted that SCIG or IVIG for IgA deficiency is usually safe.
#29 Can You Use IVIG For IgA Deficiency? – AmeriPharmaÂ® Specialty Care
https://ameripharmaspecialty.com/ivig/can-you-use-ivig-for-iga-deficiency/
IVIG therapy is not the primary treatment for IgA deficiency. Nonetheless, it may be an option if vaccines and antibiotics donât work. […] The manufacturers of IVIG products mention on the label that these products shouldnât be used in IgA-deficient people with anti-IgA antibodies. Likewise, they state that because these preparations contain mostly IgG and tiny amounts of IgA, IgA-deficient people are unlikely to benefit from them. […] However, some studies suggest that anti-IgA antibodies may not be as crucial to causing side effects as previously thought. Similarly, IgA-containing products do not always trigger anti-IgA antibodies. Notably, there have been several studies showing the safe use of IVIG for IgA deficiency, even in people with high levels of anti-IgA antibodies. […] Subcutaneous IG (SCIG) or IVIG preparations with low amounts of IgA are ideal for IgA-deficient people, as they carry a lower risk of serious side effects. A 2017 review noted that SCIG or IVIG for IgA deficiency is usually safe.
#30 Can You Use IVIG For IgA Deficiency? – AmeriPharmaÂ® Specialty Care
https://ameripharmaspecialty.com/ivig/can-you-use-ivig-for-iga-deficiency/
IVIG therapy is not the primary treatment for IgA deficiency. Nonetheless, it may be an option if vaccines and antibiotics donât work. […] The manufacturers of IVIG products mention on the label that these products shouldnât be used in IgA-deficient people with anti-IgA antibodies. Likewise, they state that because these preparations contain mostly IgG and tiny amounts of IgA, IgA-deficient people are unlikely to benefit from them. […] However, some studies suggest that anti-IgA antibodies may not be as crucial to causing side effects as previously thought. Similarly, IgA-containing products do not always trigger anti-IgA antibodies. Notably, there have been several studies showing the safe use of IVIG for IgA deficiency, even in people with high levels of anti-IgA antibodies. […] Subcutaneous IG (SCIG) or IVIG preparations with low amounts of IgA are ideal for IgA-deficient people, as they carry a lower risk of serious side effects. A 2017 review noted that SCIG or IVIG for IgA deficiency is usually safe.
#31 Can You Use IVIG For IgA Deficiency? – AmeriPharmaÂ® Specialty Care
https://ameripharmaspecialty.com/ivig/can-you-use-ivig-for-iga-deficiency/
When using IVIG for IgA deficiency or other immunodeficiencies, it is best to: Use a product with low IgA, Switch to SCIG if IVIG causes significant problems, Use IVIG premedications to counteract possible reactions, Use caution during and after treatment. […] IVIG products generally list IgA deficiency as a contraindication, meaning the product canât be used. However, contraindications for IVIG products are considered to be relative contraindications and not absolute contraindications. This means IVIG for IgA deficiency may be acceptable to use if the benefits of using the medication are greater than the risks. […] All IVIG products mention on their label that they are contraindicated in IgA-deficient people with antibodies against IgA and a history of allergy. However, this is not an absolute contraindication. The ultimate decision to use (or avoid) IVIG for IgA deficiency depends on whether the benefits outweigh the potential risks. This is the decision you and your provider must make together.
#32 Selective IgA deficiency | Health Library | Memorial Health System
https://www.mhsystem.org/health-library/con-20256724/
Selective IgA deficiency may increase the risk of other conditions related to the immune system, such as allergies, asthma, rheumatoid arthritis, inflammatory bowel diseases and others. […] There is no treatment specifically for selective IgA deficiency. Treatments focus on addressing the frequent, repeat or long-lasting conditions that develop with this immune system disorder. […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis). […] Healthcare professionals recommend wearing a medical bracelet. A bracelet can show that you have selective IgA deficiency and should receive modified blood or blood products.
#33 Low IgA & Selective IgA Deficiency: Causes & Symptoms – SelfDecode Labs
https://labs.selfdecode.com/blog/iga-deficiency/
People with IgA deficiency have a higher association of type 1 diabetes, lupus, juvenile idiopathic arthritis, IBD (both Crohns and ulcerative colitis), rheumatoid arthritis, and thyroid disorders. […] Those with IgA deficiency have a moderately increased risk of cancer, especially gut cancer. […] Low IgA levels and IgA deficiency are not the same. Any IgA value below 60 mg/dL is considered low by most labs, but only values below 7 mg/dL imply deficiency. Symptoms depend on the underlying cause.
#34 Selective IgA deficiency
https://dermnetnz.org/topics/selective-iga-deficiency
Patients with selective IgA deficiency may be asymptomatic, mildly ill, or seriously ill (2550%). Their presentations fall into three broad categories: […] Treatment is aimed at specific signs and symptoms such as: […] Antibioticssometimes prophylacticare used for infection control. […] Autoimmune disorders. These may be treated with systemic corticosteroids and other drugs to reduce inflammation or biologics (including monoclonal antibodies). Hormone replacement therapy may also be used in case of endocrine system involvement.
#35 Immunoglobulin A Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations
https://emedicine.medscape.com/article/136580-treatment
The approach to treatment of immunoglobulin A deficiency (IgAD) includes identification of comorbid conditions, preventive measures to reduce the risk of infection, and prompt, rigorous, and effective treatment of infections. […] Dietary modifications may be necessary to manage chronic diarrhea and malabsorption or food allergy in patients with immunoglobulin A deficiency (IgAD). […] A priori restrictions on activity are not necessary in immunoglobulin A deficiency (IgAD), but patients with chronic lung disease may have decreased exercise tolerance. […] Primary prevention for immunoglobulin A deficiency (IgAD) has not been developed. […] Secondary prevention relies primarily on vaccination to increase specific IgG and IgM. […] Tertiary prevention includes (1) prompt antibiotic treatment for respiratory tract infections, (2) microbial identification of diarrheal pathogens and specific treatment, (3) dietary modification for malabsorption syndromes, and (4) use of washed cells and/or IgA-poor blood if whole blood is needed, and screening for anti-IgA antibodies if reactions to blood products occur. […] Per the CDC, patients with IgAD are recommended to receive the pneumococcal Hib (for children aged 12-59 months) and recombinant zoster vaccines given their specific risks for infection.
#36 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Individuals with selective IgA deficiency may develop anti-IgA antibodies causing allergic reactions when transfused with blood products containing IgA. […] Patients with selective IgA deficiency are at a significantly higher risk of transfusion reactions compared to the general population, making careful blood product selection crucial to prevent complications. […] However, clinicians should administer blood products with caution in patients with selective IgA deficiency. […] Experts recommend screening patients with severe selective IgA deficiency and those who have experienced a reaction to blood products in the past for anti-IgA antibodies. […] Clinicians must implement a plan to safely administer blood products in patients who test positive for antibodies. […] To mitigate this risk, healthcare professionals inquire about a patient’s history of previous transfusions and any prior transfusion reactions.
#37 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Individuals with selective IgA deficiency may develop anti-IgA antibodies causing allergic reactions when transfused with blood products containing IgA. […] Patients with selective IgA deficiency are at a significantly higher risk of transfusion reactions compared to the general population, making careful blood product selection crucial to prevent complications. […] However, clinicians should administer blood products with caution in patients with selective IgA deficiency. […] Experts recommend screening patients with severe selective IgA deficiency and those who have experienced a reaction to blood products in the past for anti-IgA antibodies. […] Clinicians must implement a plan to safely administer blood products in patients who test positive for antibodies. […] To mitigate this risk, healthcare professionals inquire about a patient’s history of previous transfusions and any prior transfusion reactions.
#38 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Individuals with selective IgA deficiency may develop anti-IgA antibodies causing allergic reactions when transfused with blood products containing IgA. […] Patients with selective IgA deficiency are at a significantly higher risk of transfusion reactions compared to the general population, making careful blood product selection crucial to prevent complications. […] However, clinicians should administer blood products with caution in patients with selective IgA deficiency. […] Experts recommend screening patients with severe selective IgA deficiency and those who have experienced a reaction to blood products in the past for anti-IgA antibodies. […] Clinicians must implement a plan to safely administer blood products in patients who test positive for antibodies. […] To mitigate this risk, healthcare professionals inquire about a patient’s history of previous transfusions and any prior transfusion reactions.
#39 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Individuals with selective IgA deficiency may develop anti-IgA antibodies causing allergic reactions when transfused with blood products containing IgA. […] Patients with selective IgA deficiency are at a significantly higher risk of transfusion reactions compared to the general population, making careful blood product selection crucial to prevent complications. […] However, clinicians should administer blood products with caution in patients with selective IgA deficiency. […] Experts recommend screening patients with severe selective IgA deficiency and those who have experienced a reaction to blood products in the past for anti-IgA antibodies. […] Clinicians must implement a plan to safely administer blood products in patients who test positive for antibodies. […] To mitigate this risk, healthcare professionals inquire about a patient’s history of previous transfusions and any prior transfusion reactions.
#40 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Patients with severe selective IgA deficiency should wear medical alert identification that notifies healthcare professionals of their condition, the potential risk of anaphylactic reaction to plasma-containing blood products, and the need for anti-IgA testing before receiving transfusions. […] Methods to prevent anaphylactic reactions in patients with anti-IgA antibodies include exclusively using products from IgA-deficient donors and transfusing washed platelets and red blood cells. […] Because clinicians are unable to wash plasma, clinicians must use plasma from an IgA-deficient donor. […] For patients with anti-IgA antibodies who require immunoglobulin replacement, subcutaneous immunoglobulin is a viable alternative. […] Anaphylaxis has a biphasic reaction in approximately 5% of patients.
#41 Selective IgA deficiency | Health Library | Memorial Health System
https://www.mhsystem.org/health-library/con-20256724/
Selective IgA deficiency may increase the risk of other conditions related to the immune system, such as allergies, asthma, rheumatoid arthritis, inflammatory bowel diseases and others. […] There is no treatment specifically for selective IgA deficiency. Treatments focus on addressing the frequent, repeat or long-lasting conditions that develop with this immune system disorder. […] Antibiotic treatments are prescribed as needed to treat bacterial disease. If you have had a long-term illness, such as chronic bronchitis, you may receive antibiotics as a preventive treatment. This therapy is called antibiotic prophylaxis (pro-fuh-LAK-sis). […] Healthcare professionals recommend wearing a medical bracelet. A bracelet can show that you have selective IgA deficiency and should receive modified blood or blood products.
#42 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Patients with severe selective IgA deficiency should wear medical alert identification that notifies healthcare professionals of their condition, the potential risk of anaphylactic reaction to plasma-containing blood products, and the need for anti-IgA testing before receiving transfusions. […] Methods to prevent anaphylactic reactions in patients with anti-IgA antibodies include exclusively using products from IgA-deficient donors and transfusing washed platelets and red blood cells. […] Because clinicians are unable to wash plasma, clinicians must use plasma from an IgA-deficient donor. […] For patients with anti-IgA antibodies who require immunoglobulin replacement, subcutaneous immunoglobulin is a viable alternative. […] Anaphylaxis has a biphasic reaction in approximately 5% of patients.
#43 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Patients with severe selective IgA deficiency should wear medical alert identification that notifies healthcare professionals of their condition, the potential risk of anaphylactic reaction to plasma-containing blood products, and the need for anti-IgA testing before receiving transfusions. […] Methods to prevent anaphylactic reactions in patients with anti-IgA antibodies include exclusively using products from IgA-deficient donors and transfusing washed platelets and red blood cells. […] Because clinicians are unable to wash plasma, clinicians must use plasma from an IgA-deficient donor. […] For patients with anti-IgA antibodies who require immunoglobulin replacement, subcutaneous immunoglobulin is a viable alternative. […] Anaphylaxis has a biphasic reaction in approximately 5% of patients.
#44 Selective IgA Deficiency
https://www.aaaai.org/conditions-treatments/primary-immunodeficiency-disease/selective-iga-deficiency
Unlike many other immunoglobulin deficiencies, the condition is not treated with immunoglobulin replacement therapy. […] In cases where recurrent infections are a problem, preventative antibiotics may be used to help diminish the frequency of infections. Individuals with IgA deficiency often require a longer course of antibiotics for infections to clear up. Selective IgA deficiency can also predispose individuals to have allergic-like or anaphylactic reactions to blood transfusions or infusions of certain blood products. If you have an IgA deficiency, be certain to notify your healthcare provider so you receive modified blood products if necessary.
#45 FloridaHealthFinder | Selective deficiency of IgA | Health Encyclopedia | FloridaHealthFinder
https://quality.healthfinder.fl.gov/health-encyclopedia/HIE/1/001476
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. […] Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] Immunoglobulins are given through a vein or by injection to boost the immune system. […] If you have an IgA deficiency, be sure to mention it to your health care provider if immunoglobulin or other blood-component transfusions are suggested as a treatment for any condition. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#46 Selective IgA Deficiency in Children: Clinical Manifestations, Evaluation, and Management
https://www.contemporarypediatrics.com/view/selective-iga-deficiency-children-clinical-manifestations-evaluation-and-management
Selective IgA deficiency (SIGAD) is the most common immunodeficiency disorder; it affects about 1 in 200 to 900 persons. Most affected children are asymptomatic. […] Patients with SIGAD who have significant recurrent upper respiratory tract infections may benefit from a 6-month course of prophylactic antibiotics. These antibiotics may be continued if the initial course is successful. […] A small number of patients with SIGAD continue to have recurrent infections despite antibiotic prophylaxis. These patients may be treated with immunoglobulin replacement therapy; however, use of this treatment remains controversial. […] All children with SIGAD should be immunized according to the same schedule used for children without SIGAD and should receive the annual influenza vaccine. Most patients with SIGAD have an uncomplicated clinical course. However, continued long-term follow-up to identify other immunological abnormalities, such as CVID, autoimmune disease, and malignancy, is required.
#47 Selective IgA Deficiency in Children: Clinical Manifestations, Evaluation, and Management
https://www.contemporarypediatrics.com/view/selective-iga-deficiency-children-clinical-manifestations-evaluation-and-management
Selective IgA deficiency (SIGAD) is the most common immunodeficiency disorder; it affects about 1 in 200 to 900 persons. Most affected children are asymptomatic. […] Patients with SIGAD who have significant recurrent upper respiratory tract infections may benefit from a 6-month course of prophylactic antibiotics. These antibiotics may be continued if the initial course is successful. […] A small number of patients with SIGAD continue to have recurrent infections despite antibiotic prophylaxis. These patients may be treated with immunoglobulin replacement therapy; however, use of this treatment remains controversial. […] All children with SIGAD should be immunized according to the same schedule used for children without SIGAD and should receive the annual influenza vaccine. Most patients with SIGAD have an uncomplicated clinical course. However, continued long-term follow-up to identify other immunological abnormalities, such as CVID, autoimmune disease, and malignancy, is required.
#48 Selective IgA Deficiency : Symptoms, Causes and Treatment
https://www.apollohospitals.com/diseases-and-conditions/selective-iga-deficiency-symptoms-causes-and-treatment/
Those who are IgA-deficient but do not exhibit any symptoms do not need therapy. […] It is nevertheless essential to provide awareness and education. Medical alert bracelets should be recommended for patients with selective IgA deficiency. […] The backbone of treatment for IgA deficiency is the treatment of associated diseases. Patients who suffer from recurring infections may benefit from prophylactic antibiotics continuously or on an intermittent basis. […] Generally, SIgAD patients do well unless they have significant comorbid diseases. Children with IgA deficiency can recover over time. The patient, however, should go for regular clinical and immunological follow-up after being diagnosed with IgA deficiency.
#49 Selective IgA Deficiency : Symptoms, Causes and Treatment
https://www.apollohospitals.com/diseases-and-conditions/selective-iga-deficiency-symptoms-causes-and-treatment/
Those who are IgA-deficient but do not exhibit any symptoms do not need therapy. […] It is nevertheless essential to provide awareness and education. Medical alert bracelets should be recommended for patients with selective IgA deficiency. […] The backbone of treatment for IgA deficiency is the treatment of associated diseases. Patients who suffer from recurring infections may benefit from prophylactic antibiotics continuously or on an intermittent basis. […] Generally, SIgAD patients do well unless they have significant comorbid diseases. Children with IgA deficiency can recover over time. The patient, however, should go for regular clinical and immunological follow-up after being diagnosed with IgA deficiency.
#50 Selective deficiency of IgA Information | Mount Sinai – New York
https://www.mountsinai.org/health-library/diseases-conditions/selective-deficiency-of-iga
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms.
#51 Selective deficiency of IgA | Lima Memorial Health System
https://www.limamemorial.org/health-library/hie%20multimedia-textonly/1/001476
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#52 Selective deficiency of IgA: MedlinePlus Medical EncyclopediaLock
https://medlineplus.gov/ency/article/001476.htm
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#53 Selective deficiency of IgA | Lima Memorial Health System
https://www.limamemorial.org/health-library/hie%20multimedia-textonly/1/001476
Selective deficiency of IgA is the most common immune deficiency disorder. People with this disorder have a low or absent level of a blood protein called immunoglobulin A. […] Treatment involves taking steps to reduce the number and severity of infections. Antibiotics are often needed to treat bacterial infections. […] People with IgA deficiency should contact their health care provider if they are having symptoms of an infection or intestinal symptoms. […] Genetic counseling may be of value to prospective parents with a family history of selective IgA deficiency.
#54 Transfusion Selective IgA Deficiency | Treatment & Management | Point of Care
https://www.statpearls.com/point-of-care/28851
Therefore, clinicians must determine the appropriate length of time to monitor patients who experience anaphylaxis. […] By fostering awareness and encouraging proactive management, clinicians can help prevent life-threatening transfusion reactions and empower patients to take an active role in their health care.
#55
https://www.nicklauschildrens.org/symptoms/iga-deficiency
Immunoglobulin A, or IgA, is an antibody that is found primarily within the tissues of the body. […] A majority of patients with IgA deficiency are asymptomatic, and do not need to take specific precautions. You should be evaluated by a board certified Allergist/Immunologist to determine if you need to take special precautions with blood transfusions. […] You should see a board certified Allergist/Immunologist if you have been found to have low or absent IgA on blood work, if you have recurrent sinopulmonary infections, giardia infection, celiac disease, family history of IgA deficiency, or an anaphylactic reaction to a blood transfusion.
#56 Selective Immunoglobulin A (IgA) Deficiency – Immune Disorders – MSD Manual Consumer Version
https://www.msdmanuals.com/home/immune-disorders/immunodeficiency-disorders/selective-immunoglobulin-a-iga-deficiency
Most people with selective IgA deficiency have few or no symptoms, but some have chronic lung infections, sinusitis, and other disorders. […] Antibiotics are used to treat or sometimes to prevent infections. […] Usually, no treatment of selective IgA deficiency is needed. […] Antibiotics are given to people who have an infection. If the disorder is severe, antibiotics are given in advance to prevent infections from developing. […] People who have had an anaphylactic reaction to a blood transfusion or immune globulin should wear medical identification to alert doctors to take precautions against such reactions.