Materiały źródłowe

• #1 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7594412/

  The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytrens prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally. […] In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. The search keywords were Prevalence, Prevalent, Epidemiology, Dupuytren Contracture, Dupuytren and Incidence. […] By evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.711.7%). The highest prevalence rate is reported in Africa with 17.2% (95% CI 1322.3%).

• #2 Epidemiological Evaluation of Dupuytren’s Disease Incidence and Prevalence Rates in Relation to Etiology

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2724613/

  Dupuytrens Disease (DD) is a common, fibroproliferative disorder affecting the palmar surface of the hands which is often irreversible and progressive. Understanding the epidemiology of DD is important in order to provide clues to its etiopathogenesis. This review aims to evaluate the epidemiological studies carried out in DD since 1951. Studies evaluating the epidemiology of DD were searched using Medline, Pubmed, and Scopus which dated back from 1951 to current date. Inclusion criteria were any studies investigating the prevalence or incidence of DD in any population group. A total of 620 articles were cited. Forty-nine studies were subsequently identified as relevant to evaluating the epidemiology of DD. The prevalence of DD in all studies increased with age with a male to female ratio of approximately 5.9:1. Prevalence rates ranged from 0.2% to 56% in varying age, population groups, and methods of data collection. The highest prevalence rate was reported in a study group of epileptic patients. Although, only one study calculated the incidence (as opposed to prevalence) of DD to be equal to 34.3 per 100,000 men (0.03%). In conclusion, the prevalence of DD in different geographical locations is extremely variable, and it is not clear whether this is genetic, environmental, or a combination of both. The majority of the prevalence studies have been conducted in Scandinavia or the UK, and the vast changes in population structure, the changes in prevalence of associated diseases, and the change in diagnostic criteria of DD makes understanding the epidemiology of this condition difficult.

• #3 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis | Journal of Orthopaedic Surgery and Research | Full Text

  https://josr-online.biomedcentral.com/articles/10.1186/s13018-020-01999-7

  The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytrens prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally. […] In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. […] By evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.711.7%). The highest prevalence rate is reported in Africa with 17.2% (95% CI 1322.3%). […] The results of meta-regression revealed a decreasing trend in the prevalence of Dupuytren disease by increasing the sample size and the research year (P 0.05).

• #4 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7594412/

  The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease. […] Various studies have been conducted on the prevalence of the Dupuytren disease, which have reported a prevalence of between 0.2 and 56%. However, there is a lack of a comprehensive study with generalized statistics on the prevalence. […] According to the present study, the prevalence of Dupuytren disease in the world is 8.2% (95% CI 5.711.7%). […] Therefore, according to the subgroups analysis based on different continents, the highest rate of the prevalence of Dupuytren is related to the African continent with 17.2% (95% CI 1322.3%), and the lowest is related to the American continent with 2.3% (95% CI 1.43.8%).

• #5 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis | Journal of Orthopaedic Surgery and Research | Full Text

  https://josr-online.biomedcentral.com/articles/10.1186/s13018-020-01999-7

  The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease. […] Various studies have been conducted on the prevalence of the Dupuytren disease, which have reported a prevalence of between 0.2 and 56%. However, there is a lack of a comprehensive study with generalized statistics on the prevalence. […] According to the present study, the prevalence of Dupuytren disease in the world is 8.2% (95% CI 5.711.7%). […] Therefore, according to the subgroups analysis based on different continents, the highest rate of the prevalence of Dupuytren is related to the African continent with 17.2% (95% CI 1322.3%), and the lowest is related to the American continent with 2.3% (95% CI 1.43.8%).

• #6 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Dupuytren contracture is most commonly observed in persons of Northern European descent and affects 4-6% of Whites worldwide. […] The incidence increases with age; many patients are over 50 years old. […] Many cases are bilateral (45%); in unilateral cases, the right side is more often affected. […] Males are three times as likely to develop disease and are more likely to have higher disease severity. […] Other potential risk factors include manual labor with vibration exposure, prior hand trauma, alcoholism, smoking, diabetes mellitus, hyperlipidemia, Peyronie disease, and complex regional pain syndrome. […] Dupuytren disease occurs most often in persons of northern European ancestry. […] Dupuytren disease is common in the United States with a prevalence of 4%, reflecting immigration from Northern Europe.

• #7 Dupuytren contracture | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/dupuytren-contracture-3?embed_domain=hackmd.io%2F%40yIPUAFeCSL2JsU8smR5nJQ%2Fbnjhjgjghjghjghfavicon.icoradiopaedia-icon-144.pngfavicon.icofavicon.ico&lang=us

  Dupuytren contracture is considered the most common superficial fibromatoses. Prevalence is estimated at 1-2% of the population, increasing to 20% at the age of 65 years. There is a male predominance (~3.5:1 M:F). […] People of northern European descent are typically affected, with the highest prevalence in northern Scotland, Iceland, Norway, and Australia.

• #8 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  In Northern Europe the prevalence ranges from 4-39%. […] In Norwegian populations, 30% of males over the age of 60 years are affected. […] The incidence of Dupuytren disease for the British population in 2004 was calculated at 34.4 per 100,000 for men aged 40-84 years. […] Australia has a reported prevalence of 28%; Spain’s reported prevalence is 19% prevalence in men older than 60 years. […] Racial variation in Dupuytren disease is as follows: Dupuytren disease is most often found in Whites of Northern European descent. […] The disease prevalence in Asians is 3% and usually involves the palm rather than the digits. […] Dupuytren disease has been reported in East Africa, Zimbabwe, and Tanzania. […] Dupuytren disease is uncommon among Indians (1%), Native Americans, and patients of Hispanic descent.

• #9 Correcting Dupuytren’s Contracture

  https://www.uspharmacist.com/article/correcting-dupuytrens-contracture-1

  Due to a high prevalence (30%) of the disease in white Northern European and Norwegian males aged 60 years and older, Duputyrens disease has often been referred to as Vikings or Nordic disease.4 However, there is no evidence the disease originated in the Scandinavian population. The prevalence increases with age, from 12% in adults aged 55 years and older to 29% in those aged 75 years and older.5 Initially, it was thought Dupuytrens disease only occurred in men; however, that has been disproven with a current estimated male-to-female ratio of approximately 6:1.4 […] Dupuytrens disease is typically diagnosed based on the patients presentation, patient history, and any effect on activities of daily living.1 Huestons tabletop test is used to evaluate disease progression and can indicate the need for corrective measures. The test is considered positive for Dupuytrens when the patient cannot lay the hand flat on a table, indicating greater than 30 of MCP contracture.1

• #10 Dupuytren’s Disease Market Size | Share, Trends – 2034

  https://www.imarcgroup.com/dupuytrens-disease-market

  The Dupuytren’s disease market has been comprehensively analyzed in IMARC’s new report titled „Dupuytren’s Disease Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034”. […] The rising cases of specific genetic variations that affect the genes involved in collagen production, metabolism, and tissue remodeling are primarily driving the Dupuytren’s disease market. […] Dupuytren disease most commonly affects people of northern European heritage. […] Dupuytren’s disease is frequent in the United States, with a 4% frequency due to immigration from northern Europe. […] In Northern Europe, the prevalence ranges between 4 and 39%. […] Dupuytren disease is most commonly observed in Whites of Northern European heritage. […] The disease prevalence among Asians is 3%, and it mainly affects the palm rather than the digits.

• #11 :: JKMS :: Journal of Korean Medical Science

  https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e204

  To date, there have been few reports on the nationwide population-based epidemiology of Dupuytren’s disease (DD). […] We investigated the prevalence and incidence of DD in Korea using the large dataset provided by the Korean Health Insurance Review and Assessment Service. […] A total 16,630 patients were diagnosed with DD during the study period. The mean annual prevalence was 32.2 per 100,000 population (41.8 per 100,000 for men; 22.5 per 100,000 for women). The mean annual incidence was 1.09 per 100,000 population (1.80 per 100,000 for men; 0.38 per 100,000 for women). […] The prevalence and incidence of DD in Korea were 1001,000 times lower than those in western countries; however, it was slightly larger than that in Taiwan. […] The annual prevalence was defined as the proportion of the population with DD in the year and includes people who already have DD at the beginning of the year as well as those who acquired it during the year.

• #12 Epidemiological Evaluation of Dupuytren’s Disease Incidence and Prevalence Rates in Relation to Etiology

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2724613/

  The 49 studies identified and tabulated (Table 1) in this study dates back from 1951 to 2008 covering a range of countries from North America to East Asia and Australasia (Fig. 1). Forty-one studies were cross-sectional studies with three cohort, two longitudinal, one observational study, one questionnaire survey, and one review. The prevalence rate was calculated in 48 studies with only one study presenting an incidence rate, where numbers of new cases of DD were calculated over a period of time. The incidence rate of DD for the British population in 2004 was calculated as 34.4 per 100,000 men between the ages of 40 and 84 years with a gradual increase in incidence with increasing age. […] Two key aspects of DD epidemiology in terms of its incidence and prevalence rates are of interest. Incidence rate is defined as the number of new cases of a disease over a specified time period as a percentage of the population as opposed to the prevalence rate which is the current number of cases of disease at a single point time. This review has shown that most studies that have quoted incidence rates were in fact referring to prevalence rates. Interestingly, only one study to date has calculated an actual incidence rate of DD which identified an increasing incidence with increasing age.

• #13

  https://journals.lww.com/plasreconsurg/fulltext/2023/03000/dupuytren_disease__prevalence,_incidence,_and.24.aspx

  Health care burden attributable to Dupuytren disease (DD) is largely unknown. The authors determined (1) the prevalence and incidence of DD, (2) the incidence of first surgical intervention, and (3) the lifetime risk of surgical intervention in the United Kingdom National Healthcare Service. […] A total of 10,553,454 subjects were included in the analyses, 5,502,879 (52%) of whom were women. Of these, 38,707 DD patients were identified. Point prevalence in 2013 was 0.67% (99% CI, 0.66 to 0.68). The incidence of DD almost doubled from 0.30 (99% CI, 0.28 to 0.33) per 1000 person-years in 2000, to 0.59 (99% CI, 0.56 to 0.62) per 1000 person-years in 2013. The incidence of first surgical intervention similarly increased from 0.29 (99% CI, 0.23 to 0.37) to 0.88 (99% CI, 0.77 to 1.00) in the same period. A man or woman newly diagnosed with DD at age 65 has a lifetime risk of surgical intervention of 23% and 13%, respectively, showing only a very subtle decrease when diagnosed later in life.

• #14

  https://journals.lww.com/plasreconsurg/fulltext/2023/03000/dupuytren_disease__prevalence,_incidence,_and.24.aspx

  DD is an important health condition in the older population, because prevalence and incidence rates have almost doubled in the past decade. Estimated lifetime risk of surgical treatment is relatively low, but almost twice in men compared with women. […] The point prevalence of DD in 2013 was 0.672% (99% CI, 0.663 to 0.682). The prevalence was higher for men (0.884, 99% CI, 0.868 to 0.901) compared with women (0.469; 99% CI, 0.458 to 0.481). The prevalence of DD was highest among those aged between 75 and 85 years, both for men and for women. […] Incidence rates of DD increased during our study period, from 0.303 (99% CI, 0.282 to 0.325) per 1000 person-years in 2000 to 0.587 (99% CI, 0.559 to 0.616) per 1000 person-years in 2013, standardized for age. This increase was present in both men and women, although it was more pronounced in men.

• #15 :: JKMS :: Journal of Korean Medical Science

  https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e204

  The annual incidence was determined by the number of patients who had been assigned the M72.0 code for the first time in that year and visited medical facilities more than once during the year. […] The mean prevalence (values in parentheses indicate the adjusted value) during the study period was 32.2 (35.2)/100,000 population, 41.8 (47.9)/100,000 for men and 22.5 (23.5)/100,000 for women. […] The mean annual incidence was 1.09 (1.11)/100,000 population/year, which was 1.80 (1.89)/100,000/year for men and 0.38 (0.37)/100,000/year for women. […] The most common comorbid disease was hypertension (30.5% of DD patients); however, it was similar to the prevalence of hypertension in adult Koreans (32%). […] In conclusion, the prevalence and incidence of DD in Korea were significantly lower than those in western countries and higher than that in Taiwan.

• #16 Dupuytren contracture | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/dupuytren-contracture-3?lang=us

  Dupuytren contracture is considered the most common superficial fibromatoses. Prevalence is estimated at 1-2% of the population 12, increasing to 20% at the age of 65 years. There is a male predominance (~3.5:1 M:F) 12. […] People of northern European descent are typically affected, with the highest prevalence in northern Scotland, Iceland, Norway, and Australia 2.

• #17 Dupuytren’s Disease | IntechOpen

  https://www.intechopen.com/chapters/58492

  Dupuytrens disease is most prominent in Northern European white males, especially greater than 40 years old. A study in the Netherlands reports a prevalence as high as 22% in the general population. The study also demonstrated a propensity for older populations with ages 50-55 displaying a 4.9% prevalence, while those 76-80 years old having a prevalence of 52.6%. Men were also affected disproportionately more than women (26.4 vs. 18.6%). The prevalence in the US has been shown to approach 7.3% when including self-reported symptoms. Other epidemiological studies show a male to female ratio in the US of 1.7:1 which approaches 1:1 with increasing age. Dupuytrens disease has been linked to both genetic and environmental factors, both of which contribute to the prevalence in patient populations throughout the world.

• #18 Dupuytren’s Disease Market Size | Share, Trends – 2034

  https://www.imarcgroup.com/dupuytrens-disease-market

  Approximately 80% of those affected are male, which is consistent across all countries and races. […] What is the number of prevalent cases (2018-2034) of Dupuytren’s disease across the seven major markets? […] What is the size of the Dupuytren’s disease patient pool (2018-2023) across the seven major markets? […] What would be the forecasted patient pool (2024-2034) across the seven major markets? […] What are the key factors driving the epidemiological trend of Dupuytren’s disease? […] What will be the growth rate of patients across the seven major markets?

• #19 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Approximately 80% of affected individuals are male; this is consistent throughout all countries and races. […] The disease onset in males tends to occur in the fifth to sixth decade. […] The disease course tends to be more rapid and severe in males and increases in incidence with advancing age. […] Dupuytren disease is rare in children younger than 10 years. Only eight histologically proven cases have been reported.

• #20 Dupuytrens contracture – wikidoc

  https://www.wikidoc.org/index.php/Dupuytrens_contracture

  The prevalence of Dupuytren’s contracture among the UK population is 3-5%. […] The incidence of Dupuytren’s contracture increases with age; the median age at diagnosis is 50-70 years. […] Dupuytren’s contracture usually affects individuals of the northern Europeans race (Icelandic and Scandinavian populations). […] Males are more commonly affected by Dupuytren’s contracture than females. The male to female ratio is approximately 3 to 1.

• #21 Dupuytren’s contracture – WikiLectures

  https://www.wikilectures.eu/w/Dupuytren%27s_contracture

  Dupuytren’s contracture most often occurs in men around the age of fifty and in women approximately ten years later. Men are affected more often in a ratio of about 6:1. The disease is known to occur more frequently in the Northern European region („Viking disease”) and the disease mainly affects the white race. Dupuytren’s contracture can be considered a hereditary disease, but this disposition has incomplete penetration in the population. Diabetes mellitus, epilepsy, smoking or alcoholism are mentioned as risk factors, but the correlation is not clearly proven. However, the cause of this disease has not yet been identified. […] Recurrence (recurrence or new occurrence) of Dupuytren’s contracture after surgery varies between 20-70% according to various sources.

• #22 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7594412/

  According to the subgroups analysis of the underlying diseases, the highest prevalence is primarily in patients with type I diabetes with 34.1%. The second highest rate is among patients with type II diabetes with 25.1%. […] The results of this study reveal that the prevalence of Dupuytren disease is high, particularly in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization (WHO) are required to develop measures for the prevention and treatment of this disease.

• #23 The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis | Journal of Orthopaedic Surgery and Research | Full Text

  https://josr-online.biomedcentral.com/articles/10.1186/s13018-020-01999-7

  According to the subgroups analysis of the underlying diseases, the highest prevalence is primarily in patients with type I diabetes with 34.1%. […] Furthermore, according to the subgroups analysis of the underlying diseases, the highest prevalence of the disease, after diabetic patients, is related to alcoholic patients (24%). […] Therefore, diagnosis, prevention and treatment of this complication are essential. It is recommended that musculoskeletal examination is included as part of periodic care in diabetic patients. […] The results of this study reveal that the prevalence of Dupuytren disease is high, particularly in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization (WHO) are required to develop measures for the prevention and treatment of this disease.

• #24 The prevalence of Dupuytren’s disease in patients with diabetes mellitus | Communications Medicine

  https://www.nature.com/articles/s43856-023-00332-7

  Dupuytrens disease (DD) is a fibroproliferative hand disorder associated with various medical conditions, including diabetes mellitus (DM). The reported prevalence of DM among DD patients varies widely, primarily due to small sample sizes in previous studies. […] There is a higher prevalence of DD in patients with T2DM than in patients with T1DM (relative risk [RR]: 1.641; 95% confidence interval [CI]: [1.356, 1.986]). Among patients with diabetes, there is a higher prevalence of DD in those taking insulin compared to those taking metformin (RR: 0.801, 95% CI: [0.774, 0.83]). The prevalence of DD varies depending on HbA1c levels, with a prevalence of 0.463% in patients having levels within the diabetic range, while lower prevalences of 0.392% and 0.416% are found in patients with prediabetes or uncontrolled diabetes, respectively.

• #25 Metabolic factors and the risk of Dupuytren’s disease: data from 30,000 individuals followed for over 20 years | Scientific Reports

  https://www.nature.com/articles/s41598-021-94025-7

  The findings from this longitudinal population-based study with a median follow up of 23 years corroborate that DM and excessive alcohol consumption constitute major risk factors for the development of DD. […] Our results are in line with a previous meta-analysis on the effect of DM on the development of DD. Our study adds important information due to its longitudinal setting and long follow-up, why it contributes to the establishment of DM as a major risk factor for the development of DD. […] DM and excess alcohol consumption constituted major risk factors for the development of DD in middle-aged subjects irrespective of sex.

• #26 Dupuytren contracture – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dupuytrens-contracture/symptoms-causes/syc-20371943

  Dupuytren contracture is a condition that causes one or more fingers to bend toward the palm of the hand. The affected fingers can’t straighten completely. It most often affects the two fingers farthest from the thumb. […] Dupuytren contracture most commonly affects the two fingers farthest from the thumb. The condition often occurs in both hands. […] The cause of Dupuytren contracture is unknown. The condition tends to run in families. Its more common in men than in women. […] Risk factors for Dupuytren contracture include: Age. Dupuytren contracture occurs most commonly after the age of 50. Sex. Men are much more likely to develop Dupuytren than are women. In men, symptoms may be worse and progress more quickly. Ancestry. People of Northern European descent are at higher risk of the disease. Family history. Dupuytren contracture often runs in families. Occupation. Some studies show a connection between Dupuytren contracture and workers who use vibrating tools. Diabetes. People with diabetes have an increased risk of Dupuytren contracture. Tobacco and alcohol use. Smoking tobacco and drinking alcohol both increase the risk of Dupuytren contracture.

• #27 Dupuytren’s disease is a work-related disorder: results of a population-based cohort study | Occupational & Environmental Medicine

  https://oem.bmj.com/content/80/3/137

  Dupuytrens disease is a work-related disorder: results of a population-based cohort study […] We investigated whether current occupational exposure to manual work is associated with DD, and if there is a doseresponse relationship. […] Participants whose current occupation usually/always involved manual work were more often affected with DD than participants whose occupation sometimes/never involved manual work (OR 1.29, 95%CI 1.12 to 1.49, p0.001). […] There was a positive doseresponse relationship between cumulative manual work exposure score and DD. Each increment in cumulative work exposure score increased the odds by 17% (OR 1.17, 95%CI 1.08 to 1.27, p0.001). […] Manual work exposure is a risk factor for DD, with a clear doseresponse relationship. Physicians treating patients should recognise DD as a work-related disorder and inform patients accordingly.

• #28 Should we consider Dupuytren’s contracture as work-related? A review and meta-analysis of an old debate | BMC Musculoskeletal Disorders | Full Text

  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-12-96

  In view of the conflicting opinions published, a meta-analysis was undertaken on epidemiological studies in order to assess any association between Dupuytren’s contracture and work exposure. […] Relevant associations between manual work, vibration exposure (at work) and Dupuytren’s contracture were extracted from the articles and a metarisk calculated using the generic variance approach (meta-odds ratios, meta-OR). […] These results support the hypothesis of an association between high levels of work exposure (manual work and vibration exposure) and Dupuytren’s contracture in certain cases. […] Although there is general consensus concerning certain genetic predisposing factors and other risk factors such as diabetes, smoking and alcohol intake, the apparently conflicting results regarding the possible work-related origin of this disease are still a subject of debate.

• #29 Dupuytren contracture

  https://dermnetnz.org/topics/dupuytren-contracture

  Dupuytren contracture is a relatively common disorder that occurs with advancing age. About 515% of Caucasian men over the age of 50 years are affected. […] The incidence of Dupuytren contracture is 25 times higher in manual labourers than in office workers, possibly due to repetitive movements and vibration. […] Without treatment, Dupuytren contracture slowly progresses in about one-third of patients. No treatment can completely halt progression or cure the condition.

• #30

  https://journals.lww.com/plasreconsurg/fulltext/2023/03000/dupuytren_disease__prevalence,_incidence,_and.24.aspx

  The incidence of first surgical intervention for DD mirrored the overall incidence of disease, with an observed incidence of 0.294 per 1000 person-years (99% CI, 0.234 to 0.370) in 2000 and 0.878 per 1000 person-years (99% CI, 0.773 to 0.995) in 2013. The incidence for men was more than double the incidence for women, although for some years this difference was less pronounced. […] The lifetime risk of first surgical intervention is relatively stable for diagnosis ages 40 to 70. This may be explained by the fact that we included percutaneous needle fasciotomy as a surgical intervention, which is a minimally invasive treatment that is performed under local anaesthesia, and has no age-specific complication risks.

• #31 Dupuytren’s Disease – Dupuytren’s Contracture – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/dupuytrens-disease/

  If the condition does progress, your doctor may first recommend nonsurgical treatment to help slow the disease. […] Currently, there is no cure for Dupuytren’s; however, the condition is not life- or limb-threatening. […] The surgical procedures most commonly performed for Dupuytren’s contracture are: Fasciotomy, Partial palmar fasciectomy. […] The likelihood of complications increases with the following: The severity of the contracture, The number of contractures addressed in a single procedure, The presence of any other medical conditions. […] Most patients have improved movement in their fingers after surgery. However, because the condition is not „cured” with surgery, about 20% of patients will experience a meaningful degree of contracture recurrence (the contracture comes back).

• #32

  https://www.orthobullets.com/hand/6058/dupuytrens-disease

  Dupuytren’s Disease is a benign proliferative disorder characterized by decreased hand function that begins as a painless nodule and can progress to form diseased cords and contractures of the palm and fingers. […] Epidemiology: Incidence: common ~30 per 100,000 annually. […] Demographics: 2:1 male to female ratio, more severe disease in men than women. […] most commonly occurs in 5-7th decade of life, presents earlier in men (mean 55y) than women (mean 65y). […] ethnicity: most commonly in caucasian males of northern European descent, rare in South America, Africa, China. […] Genetics: autosomal dominant with variable penetrance, sporadic cases are more common. […] Risk factors for increased severity and recurrence after treatment: male gender, onset before age 50, bilateral disease, sibling/parent involvement. […] Dupuytren’s Diathesis: age 50, white men, bilateral hands, family history, ectopic disease outside the palm including Ledderhose, Peyronies, Garrod pads.

• #33 Dupuytren’s contracture – Wikipedia

  https://en.wikipedia.org/wiki/Dupuytren%27s_contracture

  Dupuytren’s contracture is a condition in which one or more fingers become permanently bent in a flexed position. […] It was once believed that Dupuytren’s most often occurred in white males over the age of 50 and was thought to be rare among Asians and Africans. […] In Norway, about 30% of men over 60 years old have the condition, while in the United States about 5% of people are affected at some point in time. […] In the United Kingdom, about 20% of people over 65 have some form of the disease. […] More recent and wider studies show the highest prevalence in Africa (17 percent), Asia (15 percent). […] The presence of all new Dupuytren’s diathesis factors increases the risk of recurrent Dupuytren’s disease by 71%, compared with a baseline risk of 23% in people lacking the factors. […] A scoring system was made to evaluate the risk of recurrence and extension, based on the following values: bilateral hand involvement, little-finger surgery, early onset of disease, plantar fibrosis, knuckle pads, and radial side involvement.

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