Materiały źródłowe

• #1 Dupuytren Contracture: Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/16941-dupuytrens-contracture

  Dupuytren contracture is a genetic disorder that makes the tissue under the skin of your palms and fingers thicken and tighten. […] Experts arent sure what causes Dupuytren contracture. Its considered a genetic disorder because its been proven that youre much more likely to develop Dupuytren contracture if one of your family members has had it. […] Dupuytren contracture is the most common inherited disorder that affects connective tissue.

• #2 Dupuytren Contracture – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526074/

  Dupuytren disease is a genetic disorder often inherited in an autosomal dominant fashion but is most frequently seen with a multifactorial etiology. It is associated with diabetes, seizure disorders, smoking, alcoholism, HIV, and vascular disease. […] Dupuytren contracture is a benign disorder with an etiology similar to those of similar disorders such as Peyronie disease, Ledderhose disease, and Garrod disease.

• #3 Dupuytren contracture – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dupuytrens-contracture/symptoms-causes/syc-20371943

  Dupuytren contracture is a condition that causes one or more fingers to bend toward the palm of the hand. The affected fingers can’t straighten completely. […] The cause of Dupuytren contracture is unknown. The condition tends to run in families. Its more common in men than in women.

• #4 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #5 Dupuytren’s risk factors | The British Dupuytren’s Society

  https://dupuytrens-society.org.uk/information/risk-factors/

  No one really knows what causes Dupuytren’s contracture. However, several factors have been identified that make the condition more likely, including the presence of, or a history of Ledderhose, Peyronie’s or other related conditions. […] The most common factor is genetics. Up to 70% of people who develop Dupuytren’s contracture have a family history of the condition. The gene (a unit of genetic material that determines your body’s characteristics) that causes Dupuytren’s contracture is passed to you from your parents. Dupuytren’s condition is an autosomal dominant disorder. This means that you only need to inherit the gene that causes it from one of your parents, rather than both of them, for you to get the condition. […] Diabetes is one of the biggest risk factors for Dupuytren’s. It has long been noticed by doctors that diabetics are more likely to develop signs of Dupuytren’s Disease (up to 42 %).

• #6 Dupuytren contracture: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/dupuytren-contracture/

  Dupuytren contracture is characterized by a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. […] While the cause of Dupuytren contracture is unknown, changes in one or more genes are thought to affect the risk of developing this disorder. Some of the genes associated with the disorder are involved in a biological process called the Wnt signaling pathway. […] Abnormal proliferation and differentiation of connective tissue cells called fibroblasts are important in the development of Dupuytren contracture. […] Other risk factors for developing Dupuytren contracture may include smoking; extreme alcohol use; liver disease; diabetes; high cholesterol; thyroid problems; certain medications, such as those used to treat epilepsy (anticonvulsants); and previous injury to the hand. […] Dupuytren contracture is usually passed down through generations in families and is the most common inherited disorder of connective tissue.

• #7 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Complex genetic analyses carried out by Ng and others showed no evidence to support the previously postulated theory associating Dupuytrens disease with Nordic or Viking ancestry. […] It is now known that Dupuytrens disease is caused by interactions between multiple genes that are expressed variably and in a delayed manner.

• #8 Dupuytren’s contracture – UpToDate

  https://www.uptodate.com/contents/dupuytrens-contracture

  Dupuytren’s contracture is a relatively common disorder characterized by progressive fibrosis of the palmar fascia. The cause of Dupuytren’s contracture is unknown; important factors include genetics, ethnicity, sex, and age and may include certain environmental factors and other diseases. The disorder, which more commonly affects those of northern European ancestry, appears to have a pronounced genetic predisposition; 68 percent of male relatives of affected patients develop the disease. In a study involving patients from the Netherlands, Germany, and the United Kingdom, six of nine genetic loci found associated with genetic susceptibility to Dupuytren’s disease contained genes encoding proteins in the Wnt-signaling pathway. Overstimulation of this pathway, which can regulate cellular proliferation, could potentially lead to fibroblast proliferation and nodule formation in this disorder through effects upon beta-catenin. However, the number of loci associated with Dupuytren’s has expanded greatly over the past two decades and is approaching 100.

• #9 Dupuytren’s disease

  https://www.bssh.ac.uk/patients/conditions/25/dupuytrens_disease

  Dupuytren’s disease (also referred to as Dupuytren’s contracture) is a common condition that usually arises in middle age or later and is more common in men than women. […] The cause is unknown, but it is more common in Northern Europe than elsewhere and it often runs in families. Dupuytren’s disease may be associated with diabetes, smoking and high alcohol consumption, but many affected people have none of these. […] It occasionally appears after injury to the hand or wrist, or after surgery to these areas.

• #10 Dupuytren contracture Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/dupuytren-contracture

  Dupuytren contracture is a painless thickening and tightening (contracture) of tissue beneath the skin on the palm and fingers. […] The cause is unknown. You are more likely to develop this condition if you have a family history of it. It does not seem to be caused by occupation or from trauma. […] The condition is more common after age 40. Men are affected more often than women. Risk factors are alcohol use, diabetes, and smoking.

• #11 Dupuytren’s contracture | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/dupuytrens-contracture

  Dupuytren’s contracture is a thickening and shortening of tissue in the palm, resulting in clawed fingers as they are pulled towards the hand. […] The cause of Dupuytren’s contracture is unknown, but risk factors include advancing age, Scandinavian and Celtic ancestry, and certain conditions such as epilepsy, alcoholism and diabetes. […] The exact trigger that causes the palmar fascia to thicken and contract is unknown. Potential risk factors include manual labour with vibration exposure, prior hand trauma, smoking, hyperlipidemia, Peyronie disease and complex regional pain syndrome (CRPS). A family history of the condition is often present. Other contributing factors may include: Age the condition is more common in middle to later years of life. Gender males are three times as likely to develop disease and are more likely to have the condition with more severity. Ancestry those with Celtic or Scandinavian ancestry are at increased risk. Certain medical conditions people with diabetes and epilepsy have a higher incidence of the condition, while those with rheumatoid arthritis have lower incidence. Alcoholism the contracture tends to be common, and comparatively more severe, in alcoholics.

• #12 What Are the Causes of Dupuytren’s Contracture? 3 Stages

  https://www.emedicinehealth.com/what_are_the_causes_of_dupuytrens_contracture/article_em.htm

  Dupuytren’s contracture The cause of Dupuytrens contracture is unknown. […] The cause of Dupuytrens contracture is unknown but risk factors for developing the condition include: Gender: Males are three times more likely to develop the condition and it is more severe in males […] Prior hand trauma […] Manual labor with vibration exposure […] Alcoholism […] Smoking […] Diabetes mellitus […] High levels of fats in the blood (hyperlipidemia) […] Peyronies disease (a form of erectile dysfunction) […] Complex regional pain syndrome.

• #13 Dupuytren’s Disease – Dupuytren’s Contracture – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/dupuytrens-disease/

  Dupuytren’s disease is a condition that affects the palmar fascia the fibrous layer of tissue that lies underneath the skin and above the tendons, nerves, blood vessels, and bones in the palm and fingers. […] The cause of Dupuytren’s disease is not completely known, but most evidence points toward genetics as having the most important role. […] There are anecdotal reports (based on personal accounts) of Dupuytren’s developing or worsening after a person experiences an injury or an open wound (including surgery) to their hand; however, there is no good evidence to support this. […] There are many factors that are believed to contribute to the development or worsening of Dupuytren’s disease. These include: Gender. Biologic men are more likely to develop the condition than biologic women. Ancestry. People of northern European (English, Irish, Scottish, French, and Dutch) and Scandinavian (Swedish, Norwegian, and Finnish) ancestry are more likely to develop the condition. Heredity. Dupuytren’s often runs in families. Alcohol use. Drinking alcohol may be associated with Dupuytren’s. Certain medical conditions. People with diabetes and seizure disorders are more likely to have Dupuytren’s. Age. The incidence of the condition increases with age. Trauma. Dupuytren’s disease may appear and/or worsen after trauma including surgery to the hand.

• #14 Dupuytren’s Contracture: Pictures, Symptoms, Causes, Treatments

  https://www.webmd.com/arthritis/ss/slideshow-treatment

  What Causes Dupuytren’s Contracture? […] Although reports of Dupuytren’s contracture first appeared in medical literature in the 1600s, doctors still dont know what causes the scar tissue to form. The condition tends to run in families, so genes may be involved. Dupuytren’s is more common in middle age, especially in men of Northern European descent. Alcohol and tobacco use, diabetes, and epilepsy also increase the risk.

• #15 Dupuytren’s Contracture: What is it? Symptoms, Causes & Treatment | The Hand Society

  https://www.assh.org/handcare/condition/dupuytrens-contracture

  Dupuytrens contracture is a disorder of the palm of the hand and fingers. […] The exact cause of Dupuytrens contracture is unknown and very complex. It is a hereditary disease. This means family history and ancestry play a role. The problem is more common in men, people over age 40, and people of Northern European descent. It is less common in African and Middle Eastern descent. Smoking, diabetes, alcohol, lower body mass index, and aging are also all related to Dupuytrens. […] There is no evidence that hand injuries or specific jobs lead to a higher risk of developing Dupuytrens contracture. There may be a mild relationship to trauma in someone who is at risk.

• #16 Dupuytren’s Disease – Dupuytren’s Contracture – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/dupuytrens-disease/

  Dupuytren’s disease is a condition that affects the palmar fascia the fibrous layer of tissue that lies underneath the skin and above the tendons, nerves, blood vessels, and bones in the palm and fingers. […] The cause of Dupuytren’s disease is not completely known, but most evidence points toward genetics as having the most important role. […] There are anecdotal reports (based on personal accounts) of Dupuytren’s developing or worsening after a person experiences an injury or an open wound (including surgery) to their hand; however, there is no good evidence to support this. […] There are many factors that are believed to contribute to the development or worsening of Dupuytren’s disease. These include: Gender. Biologic men are more likely to develop the condition than biologic women. Ancestry. People of northern European (English, Irish, Scottish, French, and Dutch) and Scandinavian (Swedish, Norwegian, and Finnish) ancestry are more likely to develop the condition. Heredity. Dupuytren’s often runs in families. Alcohol use. Drinking alcohol may be associated with Dupuytren’s. Certain medical conditions. People with diabetes and seizure disorders are more likely to have Dupuytren’s. Age. The incidence of the condition increases with age. Trauma. Dupuytren’s disease may appear and/or worsen after trauma including surgery to the hand.

• #17 Dupuytren Contracture – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526074/

  Dupuytren disease is a genetic disorder often inherited in an autosomal dominant fashion but is most frequently seen with a multifactorial etiology. It is associated with diabetes, seizure disorders, smoking, alcoholism, HIV, and vascular disease. […] Dupuytren contracture is a benign disorder with an etiology similar to those of similar disorders such as Peyronie disease, Ledderhose disease, and Garrod disease.

• #18 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #19 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Others believe that Dupuytren contracture has a multifactorial inheritance, similar to diabetes or hypertension. […] A large, retrospective study by Loos and colleagues on 2919 hands on which surgery had been performed revealed no statistically significant evidence that the occurrence of Dupuytren contracture could be correlated with the presence of diabetes, with alcoholism, or with smoking. […] Diabetes mellitus has been identified as a risk factor. […] Dupuytren disease in patients with diabetes ranges from 1.6-32%, the prevalence of diabetes in patients with Dupuytren disease is 5%. […] A 3-fold increased risk for Dupuytren contracture is seen in individuals who smoke, even when studies control for alcohol use, perhaps due to microvascular impairment. […] Two studies have shown increased sensitivity to androgens in the palmar fascia. […] This may account for the male predominance of the disease.

• #20 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #21 Dupuytren’s Disease: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0701/p86.html

  Dupuytren’s disease is common in men older than 40 years; in persons of Northern European descent; and in persons who smoke, use alcohol, or have diabetes. […] There is a strong association between diabetes and Dupuytren’s disease. Studies have found a 3 to 33 percent prevalence of Dupuytren’s in patients with diabetes; however, these patients tend to have a mild form of Dupuytren’s with slow progression. […] Greater alcohol intake per week is associated with increased risk of Dupuytren’s disease, but most patients with the disease are not alcoholics. […] Smoking also increases the risk of the disease. […] Although trauma has been reported as a cause of Dupuytren’s disease, studies have had mixed results. […] A connection between epilepsy and Dupuytren’s disease has been reported, and some symptoms (e.g., palmar cords, knuckle pad thickening) have been shown to regress when anticonvulsant medications are discontinued. However, more recent, large cohort studies have not found an association between the disease and epilepsy or the use of epilepsy medication.

• #22 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #23 Dupuytren’s risk factors | The British Dupuytren’s Society

  https://dupuytrens-society.org.uk/information/risk-factors/

  The causal relationship is unknown, but one could speculate that poor circulation in the extremities (often seen in diabetic patients) may lead to hypoxia, ischaemia and thus to increased levels of TGF and PDGF, setting the whole Dupuytren’s reaction off. […] It used to be believed that epilepsy was a risk factor for Dupuytren’s. It now seems more likely that the risk was actually from the medication most commonly taken for epilepsy. […] Smoking is a big risk factor for Dupuytren’s Disease. […] Drinking alcohol seems to increase the risk of developing Dupuytren’s, especially for those drinking more than 5 units per week. […] There is more evidence of a link between liver cirrhosis and Dupuytren’s, where the cause of the cirrhosis was not significant. […] A 1990 study suggests a higher incidence in HIV positive patients, whereas another study by does not.

• #24 Dupuytren Contracture – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526074/

  Dupuytren disease is a genetic disorder often inherited in an autosomal dominant fashion but is most frequently seen with a multifactorial etiology. It is associated with diabetes, seizure disorders, smoking, alcoholism, HIV, and vascular disease. […] Dupuytren contracture is a benign disorder with an etiology similar to those of similar disorders such as Peyronie disease, Ledderhose disease, and Garrod disease.

• #25 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #26 Dupuytren’s Contracture: Causes, Symptoms, and Treatment

  https://www.webmd.com/a-to-z-guides/dupuytrens-disease-topic-overview

  The cause of Dupuytren’s disease is unknown, but certain biochemical factors that affect the palm’s connective tissue may be involved. Injuries and overuse of the hand dont cause it. Tendons arent affected. […] However, certain things may make you more likely to develop Dupuytren’s contracture. They include: Drinking a lot of alcohol, although most people with the disease do not have alcoholism, Diabetes, Seizures, such as those seen in people with epilepsy, Smoking, Having a relative with the condition, Being of Northern European (English, Irish, Scottish, French, Dutch) or Scandinavian (Swedish, Norwegian, Finnish) descent, Being a man over 40.

• #27 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Others believe that Dupuytren contracture has a multifactorial inheritance, similar to diabetes or hypertension. […] A large, retrospective study by Loos and colleagues on 2919 hands on which surgery had been performed revealed no statistically significant evidence that the occurrence of Dupuytren contracture could be correlated with the presence of diabetes, with alcoholism, or with smoking. […] Diabetes mellitus has been identified as a risk factor. […] Dupuytren disease in patients with diabetes ranges from 1.6-32%, the prevalence of diabetes in patients with Dupuytren disease is 5%. […] A 3-fold increased risk for Dupuytren contracture is seen in individuals who smoke, even when studies control for alcohol use, perhaps due to microvascular impairment. […] Two studies have shown increased sensitivity to androgens in the palmar fascia. […] This may account for the male predominance of the disease.

• #28 Dupuytren’s risk factors | The British Dupuytren’s Society

  https://dupuytrens-society.org.uk/information/risk-factors/

  The causal relationship is unknown, but one could speculate that poor circulation in the extremities (often seen in diabetic patients) may lead to hypoxia, ischaemia and thus to increased levels of TGF and PDGF, setting the whole Dupuytren’s reaction off. […] It used to be believed that epilepsy was a risk factor for Dupuytren’s. It now seems more likely that the risk was actually from the medication most commonly taken for epilepsy. […] Smoking is a big risk factor for Dupuytren’s Disease. […] Drinking alcohol seems to increase the risk of developing Dupuytren’s, especially for those drinking more than 5 units per week. […] There is more evidence of a link between liver cirrhosis and Dupuytren’s, where the cause of the cirrhosis was not significant. […] A 1990 study suggests a higher incidence in HIV positive patients, whereas another study by does not.

• #29 Dupuytren’s Disease: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0701/p86.html

  Dupuytren’s disease is common in men older than 40 years; in persons of Northern European descent; and in persons who smoke, use alcohol, or have diabetes. […] There is a strong association between diabetes and Dupuytren’s disease. Studies have found a 3 to 33 percent prevalence of Dupuytren’s in patients with diabetes; however, these patients tend to have a mild form of Dupuytren’s with slow progression. […] Greater alcohol intake per week is associated with increased risk of Dupuytren’s disease, but most patients with the disease are not alcoholics. […] Smoking also increases the risk of the disease. […] Although trauma has been reported as a cause of Dupuytren’s disease, studies have had mixed results. […] A connection between epilepsy and Dupuytren’s disease has been reported, and some symptoms (e.g., palmar cords, knuckle pad thickening) have been shown to regress when anticonvulsant medications are discontinued. However, more recent, large cohort studies have not found an association between the disease and epilepsy or the use of epilepsy medication.

• #30 Dupuytren’s contracture

  https://www.nhs.uk/conditions/dupuytrens-contracture/

  Dupuytren’s contracture happens when the tissue under the skin near your fingers becomes thicker and less flexible. […] The exact cause is unknown, but it’s been linked to: having a family history of the condition, smoking, drinking lots of alcohol, having diabetes or epilepsy. […] It’s not known if you can prevent it or stop it coming back.

• #31 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #32 Dupuytren’s Contracture (and its link frozen shoulder)

  https://www.painscience.com/articles/dupuytrens-contracture.php

  Dupuytrens contracture causes a slow and mostly painless thickening of the connective tissue (fascia) and tendons of the palm. […] This disease is mostly genetic, mainly affecting aging white men. But it has a list of other risk factors and triggers like alcoholism, being skinny, hand injuries, diabetes, and smoking of course (it seems to be a risk factor for everything). But the biggest risk factor, and most interesting, is working with vibrating tools. […] Whatever causes Dupuytrens contracture also affects some other tissues. […] If you have one, it does increase the risk of the others. […] The malfunction at the root of Dupuytrens contracture is still unexplained and therefore untreatable. […] Working with vibrating tools is the major non-genetic risk factor for Dupuytrens contracture.

• #33 Dupuytren’s Disease – Dupuytren’s Contracture – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/dupuytrens-disease/

  Dupuytren’s disease is a condition that affects the palmar fascia the fibrous layer of tissue that lies underneath the skin and above the tendons, nerves, blood vessels, and bones in the palm and fingers. […] The cause of Dupuytren’s disease is not completely known, but most evidence points toward genetics as having the most important role. […] There are anecdotal reports (based on personal accounts) of Dupuytren’s developing or worsening after a person experiences an injury or an open wound (including surgery) to their hand; however, there is no good evidence to support this. […] There are many factors that are believed to contribute to the development or worsening of Dupuytren’s disease. These include: Gender. Biologic men are more likely to develop the condition than biologic women. Ancestry. People of northern European (English, Irish, Scottish, French, and Dutch) and Scandinavian (Swedish, Norwegian, and Finnish) ancestry are more likely to develop the condition. Heredity. Dupuytren’s often runs in families. Alcohol use. Drinking alcohol may be associated with Dupuytren’s. Certain medical conditions. People with diabetes and seizure disorders are more likely to have Dupuytren’s. Age. The incidence of the condition increases with age. Trauma. Dupuytren’s disease may appear and/or worsen after trauma including surgery to the hand.

• #34 Dupuytren’s Contracture | Causes & Treatment

  https://patient.info/bones-joints-muscles/dupuytrens-contracture-leaflet

  Dupuytren’s contracture causes thickening of tissues (fascia) in the palm. […] The cause is not known. […] The reason why this tissue becomes thickened is not known. […] There seems to be a genetic factor as it has a tendency to run in families, so there may be a family history. […] It is more common in some countries – mainly Northern European. […] It is more common in people with diabetes, epilepsy, and alcohol dependence. However, most people with Dupuytren’s contracture do not have any of these other conditions. […] Smoking is a risk factor, as is heavy manual work and the use of vibrating tools. […] In some cases it is thought that an injury to the hand may trigger the condition to start in someone who is genetically prone to develop the condition. […] However, in most people with Dupuytren’s contracture, there is no known cause or associated illness or injury.

• #35 Dupuytren’s contracture – UpToDate

  https://www.uptodate.com/contents/dupuytrens-contracture

  Pathologically, Dupuytren’s contracture is characterized by fibroblastic proliferation and disorderly collagen deposition with fascial thickening. Formation of a nodule or nodules occurs in the early proliferative stage of the disease and is the pathognomonic lesion of Dupuytren’s contracture. Nodules form due to proliferation of fibroblasts in the superficial palmar fascia and histologically are composed of fibroblasts and type III collagen. Smooth muscle fibroblasts and myofibroblasts are present in the nodules; increased concentrations of prostaglandins are also found within the nodules and may influence myofibroblast contractility. The presence of CD3-positive lymphocytes and the expression of major histocompatibility complex (MHC) class II proteins also suggest a possible role for a T-cell mediated autoimmune response in this disorder.

• #36 Dupuytren contracture: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/dupuytren-contracture/

  Dupuytren contracture is characterized by a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. […] While the cause of Dupuytren contracture is unknown, changes in one or more genes are thought to affect the risk of developing this disorder. Some of the genes associated with the disorder are involved in a biological process called the Wnt signaling pathway. […] Abnormal proliferation and differentiation of connective tissue cells called fibroblasts are important in the development of Dupuytren contracture. […] Other risk factors for developing Dupuytren contracture may include smoking; extreme alcohol use; liver disease; diabetes; high cholesterol; thyroid problems; certain medications, such as those used to treat epilepsy (anticonvulsants); and previous injury to the hand. […] Dupuytren contracture is usually passed down through generations in families and is the most common inherited disorder of connective tissue.

• #37 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Al-Qattan hypothesizes that an individual with a genetic predisposition to develop Dupuytren disease experiences a second inciting event (ie, smoking, diabetes, trauma, alcoholism), resulting in microvascular ischemia. […] The localized ischemia causes two events to take place in the palmar fascia: (1) the conversion of adenosine triphosphate to hypoxanthine and (2) the conversion of xanthine dehydrogenase to xanthine oxidase. […] Increased levels of nerve growth factor are present, which induce fibroblast transformation to myofibroblasts, especially during stages II-III. […] The ratio of type III collagen to type I collagen increases, the reverse of the normal pattern, in the palmar fascia. […] A genomewide association study of 960 persons with Dupuytren disease and 3117 controls all from the Netherlands and of European descent identified 11 single-nucleotide polymorphisms (SNPs) from nine different loci involved in genetic susceptibility to Dupuytren disease.

• #38

  https://www.orthobullets.com/hand/6058/dupuytrens-disease

  Dupuytren’s Disease is a benign proliferative disorder characterized by decreased hand function that begins as a painless nodule and can progress to form diseased cords and contractures of the palm and fingers. […] Etiology includes cytokine-mediated transformation of normal fibroblasts into abnormal myofibroblasts, turning normal fascial bands into pathological cords. […] Risk factors for increased severity and recurrence after treatment include male gender, onset before age 50, bilateral disease, and sibling/parent involvement. […] Cytokines released by macrophages and lymphocytes have been implicated, including TGFbeta1, TGFbeta2, epidermal growth factor, PDGF, and connective tissue growth factor. […] An increase in the ratio of type III to type I collagen and an increase in free radical formation are also noted in the etiology of Dupuytren’s contracture.

• #39 Dupuytren’s contracture – UpToDate

  https://www.uptodate.com/contents/dupuytrens-contracture

  Pathologically, Dupuytren’s contracture is characterized by fibroblastic proliferation and disorderly collagen deposition with fascial thickening. Formation of a nodule or nodules occurs in the early proliferative stage of the disease and is the pathognomonic lesion of Dupuytren’s contracture. Nodules form due to proliferation of fibroblasts in the superficial palmar fascia and histologically are composed of fibroblasts and type III collagen. Smooth muscle fibroblasts and myofibroblasts are present in the nodules; increased concentrations of prostaglandins are also found within the nodules and may influence myofibroblast contractility. The presence of CD3-positive lymphocytes and the expression of major histocompatibility complex (MHC) class II proteins also suggest a possible role for a T-cell mediated autoimmune response in this disorder.

• #40 Dupuytren’s contracture – UpToDate

  https://www.uptodate.com/contents/dupuytrens-contracture

  Pathologically, Dupuytren’s contracture is characterized by fibroblastic proliferation and disorderly collagen deposition with fascial thickening. Formation of a nodule or nodules occurs in the early proliferative stage of the disease and is the pathognomonic lesion of Dupuytren’s contracture. Nodules form due to proliferation of fibroblasts in the superficial palmar fascia and histologically are composed of fibroblasts and type III collagen. Smooth muscle fibroblasts and myofibroblasts are present in the nodules; increased concentrations of prostaglandins are also found within the nodules and may influence myofibroblast contractility. The presence of CD3-positive lymphocytes and the expression of major histocompatibility complex (MHC) class II proteins also suggest a possible role for a T-cell mediated autoimmune response in this disorder.

• #41 Dupuytren’s contracture – UpToDate

  https://www.uptodate.com/contents/dupuytrens-contracture

  Pathologically, Dupuytren’s contracture is characterized by fibroblastic proliferation and disorderly collagen deposition with fascial thickening. Formation of a nodule or nodules occurs in the early proliferative stage of the disease and is the pathognomonic lesion of Dupuytren’s contracture. Nodules form due to proliferation of fibroblasts in the superficial palmar fascia and histologically are composed of fibroblasts and type III collagen. Smooth muscle fibroblasts and myofibroblasts are present in the nodules; increased concentrations of prostaglandins are also found within the nodules and may influence myofibroblast contractility. The presence of CD3-positive lymphocytes and the expression of major histocompatibility complex (MHC) class II proteins also suggest a possible role for a T-cell mediated autoimmune response in this disorder.

• #42 Understanding Dupuytren’s Contracture: A Deep Dive into Symptoms, Causes, and Treatment Options | Central Health Physiotherapy

  https://www.central-health.com/blog/understanding-dupuytrens-contracture-a-deep-dive-into-symptoms-causes-and-treatment-options/

  Dupuytren contracture is a condition where the fascia, the fibrous layer of tissue that lies beneath the skin in the palm and fingers, becomes thickened and tight. […] While the exact cause of Dupuytrens contracture is unknown, it involves a change in the tissue under the skin of the palm of the hand. Over time, this tissue can thicken and shorten, pulling the affected fingers inward. Research has shown it could be linked to an autoimmune reaction, where the body mistakenly attacks its own tissues. […] Genetics play a significant role in people with Dupuytrens contracture, most often running in families. Research shows that specific genes may influence the likelihood of developing the condition, highlighting the hereditary nature of the condition.

• #43 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Al-Qattan hypothesizes that an individual with a genetic predisposition to develop Dupuytren disease experiences a second inciting event (ie, smoking, diabetes, trauma, alcoholism), resulting in microvascular ischemia. […] The localized ischemia causes two events to take place in the palmar fascia: (1) the conversion of adenosine triphosphate to hypoxanthine and (2) the conversion of xanthine dehydrogenase to xanthine oxidase. […] Increased levels of nerve growth factor are present, which induce fibroblast transformation to myofibroblasts, especially during stages II-III. […] The ratio of type III collagen to type I collagen increases, the reverse of the normal pattern, in the palmar fascia. […] A genomewide association study of 960 persons with Dupuytren disease and 3117 controls all from the Netherlands and of European descent identified 11 single-nucleotide polymorphisms (SNPs) from nine different loci involved in genetic susceptibility to Dupuytren disease.

• #44 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Al-Qattan hypothesizes that an individual with a genetic predisposition to develop Dupuytren disease experiences a second inciting event (ie, smoking, diabetes, trauma, alcoholism), resulting in microvascular ischemia. […] The localized ischemia causes two events to take place in the palmar fascia: (1) the conversion of adenosine triphosphate to hypoxanthine and (2) the conversion of xanthine dehydrogenase to xanthine oxidase. […] Increased levels of nerve growth factor are present, which induce fibroblast transformation to myofibroblasts, especially during stages II-III. […] The ratio of type III collagen to type I collagen increases, the reverse of the normal pattern, in the palmar fascia. […] A genomewide association study of 960 persons with Dupuytren disease and 3117 controls all from the Netherlands and of European descent identified 11 single-nucleotide polymorphisms (SNPs) from nine different loci involved in genetic susceptibility to Dupuytren disease.

• #45

  https://www.orthobullets.com/hand/6058/dupuytrens-disease

  Dupuytren’s Disease is a benign proliferative disorder characterized by decreased hand function that begins as a painless nodule and can progress to form diseased cords and contractures of the palm and fingers. […] Etiology includes cytokine-mediated transformation of normal fibroblasts into abnormal myofibroblasts, turning normal fascial bands into pathological cords. […] Risk factors for increased severity and recurrence after treatment include male gender, onset before age 50, bilateral disease, and sibling/parent involvement. […] Cytokines released by macrophages and lymphocytes have been implicated, including TGFbeta1, TGFbeta2, epidermal growth factor, PDGF, and connective tissue growth factor. […] An increase in the ratio of type III to type I collagen and an increase in free radical formation are also noted in the etiology of Dupuytren’s contracture.

• #46 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Dupuytrens-Contracture-Genetics.aspx

  Yet, many who have Dupuytrens disease do not have these issues. Some research indicates that any correlations between these conditions and Dupuytrens are not significant. […] Some also believe that previous hand trauma may increase the chance for Dupuytrens to occur, but such a link to the condition is not clear. Some investigations have indicated that a connection exists between Dupuytren’s contracture and manual labor. […] Some researchers indicate that modifications occurring in certain genes influence the potential for the onset of Dupuytrens. […] Yet, scientists have not been able to make a connection as to how modifications in genes that affect the Wnt signaling pathway may be related to how the condition comes about. […] However, other research relates to transforming growth factor beta one (TGF beta 1), a multifunctional cytokine that significantly influences connective tissue and how wounds heal. […] Earlier research established a relationship between TGF beta 1 and Dupuytrens. It may involve a gene that makes one susceptible to the disease. […] Yet some observers think that common TGF beta 1 polymorphisms do not have a link to the onset of Dupuytrens.

• #47

  https://www.orthobullets.com/hand/6058/dupuytrens-disease

  Dupuytren’s Disease is a benign proliferative disorder characterized by decreased hand function that begins as a painless nodule and can progress to form diseased cords and contractures of the palm and fingers. […] Etiology includes cytokine-mediated transformation of normal fibroblasts into abnormal myofibroblasts, turning normal fascial bands into pathological cords. […] Risk factors for increased severity and recurrence after treatment include male gender, onset before age 50, bilateral disease, and sibling/parent involvement. […] Cytokines released by macrophages and lymphocytes have been implicated, including TGFbeta1, TGFbeta2, epidermal growth factor, PDGF, and connective tissue growth factor. […] An increase in the ratio of type III to type I collagen and an increase in free radical formation are also noted in the etiology of Dupuytren’s contracture.

• #48 Dupuytren Contracture: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/329414-overview

  Others believe that Dupuytren contracture has a multifactorial inheritance, similar to diabetes or hypertension. […] A large, retrospective study by Loos and colleagues on 2919 hands on which surgery had been performed revealed no statistically significant evidence that the occurrence of Dupuytren contracture could be correlated with the presence of diabetes, with alcoholism, or with smoking. […] Diabetes mellitus has been identified as a risk factor. […] Dupuytren disease in patients with diabetes ranges from 1.6-32%, the prevalence of diabetes in patients with Dupuytren disease is 5%. […] A 3-fold increased risk for Dupuytren contracture is seen in individuals who smoke, even when studies control for alcohol use, perhaps due to microvascular impairment. […] Two studies have shown increased sensitivity to androgens in the palmar fascia. […] This may account for the male predominance of the disease.

• #49 Dupuytren’s Disease—Etiology and Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8864671/

  Genetic factors account for 80% of the factors involved in causing this disease. […] Additional associations exist with particular diseases such as diabetes mellitus (types 1 and 2) (odds ratio [OR] 3.06, 95% confidence interval [2.69; 3.48]), liver disease (OR 2.92 [2.08; 4.12]), and epilepsy (OR 2.80 [2.49; 3.15]); no specific form of epilepsy or anticonvulsant medication has been identified. […] Working with vibrating tools for many years (vibration exposure) is also significantly associated with Dupuytrens disease, with an OR of 2.87 [1.41; 5.84] according to a recent meta-analysis. […] Factors such as a positive family history, bilateral disease, age at onset below 50 years, the presence of concomitant diseases such as Ledderhoses disease (idiopathic fibrosis of the plantar aponeurosis), Peyronies disease (induratio penis plastica), and Garrods pads (knuckle pads or Garrods nodules) are predictors of recurrence.

• #50 Dupuytren’s Contracture Facts and Statistics: What You Need to Know

  https://www.verywellhealth.com/dupuytrens-contracture-7092628

  Dupuytren’s contracture is a disorder that affects the hand. This condition begins with nodules that form in the palm, which can grow into thick cords of tissue. As these cords continue to grow, fingers can be pulled into a bent position, causing a contracture meaning they are stuck in that position and cannot be straightened out. […] The exact cause of Dupuytren’s contracture is not known. However, certain risk factors make it more likely for a person to develop this condition. […] Dupuytren’s contracture often runs in families. Other possible risk factors for this condition include: Smoking, Prior trauma to the hand, Occupations that require manual labor, Blood circulation in the hand, Long-term use of antiretroviral medications (drugs used to treat human immunodeficiency virus (HIV)), Long-term use of anticonvulsant medications (anti-seizure medications), Excessive alcohol consumption.

• #51 Dupuytren’s Contracture Facts and Statistics: What You Need to Know

  https://www.verywellhealth.com/dupuytrens-contracture-7092628

  Dupuytren’s contracture is also more common in people with certain medical conditions, including: High cholesterol, Diabetes, Thyroid conditions, Liver disease, Other metabolic disorders. […] Dupuytren’s contracture (also called Dupuytren’s disease) is caused by abnormally thick fascia in the palm. Nodules develop first, then grow into thick cords of tissue. Over time, this can pull the fingers into a bent position.

• #52 Dupuytren’s Contracture Symptoms & Causes | Spire Healthcare

  https://www.spirehealthcare.com/conditions/dupuytrens-contracture/

  Dupuytren’s contracture is a common condition affecting around one in 20 people in the UK. Its six times more common in men than women and more common in older people. […] The exact cause of Dupuytren’s contracture is still unknown, but it’s been linked to: A family history of the condition, Being of northern European descent, Diabetes or epilepsy, Injury or surgery to the hand or wrist especially in someone who has a family history of the condition, Lifestyle factors drinking a lot of alcohol, smoking and using vibrating hand tools. […] However, most people with Dupuytren’s contracture do not have any of these risk factors. It is not yet known whether this condition can be prevented or stopped from returning. […] Dupuytren’s contracture is not an autoimmune disease. The exact cause of the condition is unknown but is linked to: A family history of the condition, Being of northern European descent, Diabetes or epilepsy, Injury or surgery to the hand or wrist especially in someone who has a family history of the condition, Lifestyle factors drinking a lot of alcohol, smoking and using vibrating hand tools. […] However, most people with Dupuytren’s contracture do not have any of these risk factors.

• #53 Dupuytren’s Contracture | Causes & Treatment

  https://patient.info/bones-joints-muscles/dupuytrens-contracture-leaflet

  Dupuytren’s contracture causes thickening of tissues (fascia) in the palm. […] The cause is not known. […] The reason why this tissue becomes thickened is not known. […] There seems to be a genetic factor as it has a tendency to run in families, so there may be a family history. […] It is more common in some countries – mainly Northern European. […] It is more common in people with diabetes, epilepsy, and alcohol dependence. However, most people with Dupuytren’s contracture do not have any of these other conditions. […] Smoking is a risk factor, as is heavy manual work and the use of vibrating tools. […] In some cases it is thought that an injury to the hand may trigger the condition to start in someone who is genetically prone to develop the condition. […] However, in most people with Dupuytren’s contracture, there is no known cause or associated illness or injury.

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