Materiały źródłowe

• #1 Soft Tissue Sarcoma Treatment – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/patient/adult-soft-tissue-treatment-pdq

  Soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. […] Soft tissue sarcoma is diagnosed with a biopsy. […] Certain factors affect treatment options and prognosis (chance of recovery). […] The treatment options and prognosis depend on the following: The type of soft tissue sarcoma. The size, grade, and stage of the tumor. Where the tumor is in the body. Whether all of the tumor is removed by surgery. The patient’s age and general health. Whether the cancer has recurred (come back). […] There are different types of treatment for patients with soft tissue sarcoma. […] The following types of treatment are used: Surgery, Radiation therapy, Chemotherapy, Targeted therapy, Immunotherapy. […] Surgery is the most common treatment for soft tissue sarcoma. It may be the only treatment needed for small, low-grade tumors, especially in the trunk, arms, or legs.

• #1 Soft tissue sarcoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/soft-tissue-sarcoma/diagnosis-treatment/drc-20377730

  Tests and procedures used to diagnose soft tissue sarcoma include imaging tests and procedures to remove a sample of cells for testing. […] Treatment options for soft tissue sarcoma will depend on the size, type and location of the cancer. […] Surgery is a common treatment for soft tissue sarcoma. During surgery, the surgeon usually removes the cancer and some healthy tissue around it. […] Soft tissue sarcoma often affects the arms and legs. In the past, surgery to remove an arm or leg was common. Today, other approaches are used, when possible. For example, radiation and chemotherapy might be used to shrink the cancer. That way the cancer can be removed without needing to remove the entire limb. […] Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons and other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to specific points on your body.

• #1 Management of soft-tissue sarcomas; treatment strategies, staging, and outcomes | SICOT-J

  https://www.sicot-j.org/articles/sicotj/full_html/2017/01/sicotj160134/sicotj160134.html

  The overall treatment goal is to achieve maximal oncologic control and render the least functional impairment. […] Radiation therapy is recommended for all STS where surgery will provide less than a wide negative resection margin. Adjuvant radiation can be given preoperatively or postoperatively and this was the subject of a randomized clinical trial (RCT). […] Surgical margin has an important impact on outcome because it may be the only independent risk factor under the surgeons control in the treatment of an extremity STS. […] The definition of a safe surgical margin continues to evolve during the limb-salvage era. […] The primary goal of oncologic surgery is to achieve negative surgical margins, and this often means that large soft-tissue defects are left following resection which are not amenable to primary wound closure.

• #1 Soft tissue sarcoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/soft-tissue-sarcoma

  Because sarcoma is a rare cancer, you will be treated at a specialist sarcoma unit. A team of specialists will meet to discuss the best possible treatment for you. This is called a multidisciplinary team (MDT). […] Your treatment for soft tissue sarcoma depends on a few things, including: the type of sarcoma, where it started, the stage and grade of the sarcoma, your general health. […] Your cancer doctor or specialist nurse will explain the different treatments and their side effects. They will also talk to you about things to consider when making treatment decisions. […] The following treatments may be used to treat soft tissue sarcoma. Most people need a combination of these treatments. […] Surgery is the most common treatment for soft tissue sarcoma. If you have a bone sarcoma in an arm or leg, it is usually possible to remove the sarcoma with limb-sparing surgery. Very rarely, the best treatment is to remove the whole of the affected limb (amputation). Some people might need reconstructive surgery to repair the area of the surgery.

• #1 Soft tissue sarcoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/soft-tissue-sarcoma/diagnosis-treatment/drc-20377730

  Radiation before surgery can shrink a tumor to make it easier to remove. […] Radiation during surgery allows more radiation to be delivered directly to the target area. This can spare healthy tissues around the target area. […] Radiation may be used after surgery to kill any cancer cells that remain. […] Chemotherapy uses strong medicines to kill cancer cells. The medicines are often given through a vein, though some are available in pill form. Some types of soft tissue sarcoma respond better to chemotherapy than do others. […] Targeted therapy uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Your cancer cells might be tested to see if targeted therapy might be helpful for you. This treatment works well for some types of soft tissue sarcoma, such as gastrointestinal stromal tumors, also called GISTs.

• #1 5 Innovative Soft Tissue Sarcoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/soft-tissue-sarcoma/soft-tissue-sarcoma-treatment.html

  Radiation therapy usually is not used as the main treatment for sarcoma, but it may be used before surgery to shrink the tumor or after surgery to destroy remaining cancer cells. […] Proton therapy delivers high radiation doses directly to the tumor site, sparing nearby healthy tissue and vital organs. For some patients, this therapy results in better cancer control with less impact on the body. […] Your doctor might request specific genomic or molecular profiling to help find therapies to fight the disease. […] MD Anderson is committed to providing you with the most advanced treatments for sarcoma with the least impact on your body. Your sarcoma treatment is customized specifically for you by one of the world’s foremost teams of experts. […] Statistics show that sarcoma patients have better outcomes when they are treated at large comprehensive cancer centers where specialized oncologists have more experience with the disease.

• #1 Guidelines for the Management of Soft Tissue Sarcomas

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2903951/

  Surgery is the standard treatment for all patients with adult-type, localised soft tissue sarcomas, and it should be performed by an appropriately trained surgeon. […] For patients who have undergone surgery and have an unplanned positive margin, re-excision should be undertaken if adequate margins can be achieved. […] Postoperative radiotherapy is considered to be the standard approach for nearly all intermediate or high-grade soft tissue sarcomas. […] The role of adjuvant chemotherapy remains unproven. Although currently not regarded as standard treatment in the UK, there is conflicting evidence, and it may be considered for individual patients with potentially chemosensitive subtypes on the basis that benefit cannot be excluded, even though it has not been proven. […] Systemic treatments for the majority of advanced STS are not curative; median survival time is 12 months from diagnosis of metastases.

• #1 Soft Tissue Sarcoma Treatment – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/patient/adult-soft-tissue-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. […] Immunotherapy is a treatment that uses the patient’s immune system to fight cancer. […] Treatment for soft tissue sarcoma may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment of stage I soft tissue sarcoma may include the following: Surgery to remove the tumor, such as Mohs microsurgery for small sarcomas of the skin, wide local excision, or limb-sparing surgery.

• #1 Medications for Soft Tissue Sarcoma | NYU Langone Health

  https://nyulangone.org/conditions/soft-tissue-sarcoma/treatments/medications-for-soft-tissue-sarcoma

  Chemotherapy given before surgery, also called neoadjuvant chemotherapy, may be used to shrink large tumors, making surgery a more feasible, safe, and successful option. This approach also reduces the need for amputation of a limb and lessens the risk of the cancer coming back. Chemotherapy, on occasion, may be given after surgery to destroy tumor cells that have spread to other parts of the body. […] Based on the subtype of soft tissue sarcoma, your doctor may prescribe targeted medications as part of your treatment. […] For example, gastrointestinal stromal tumor sarcoma may respond to targeted therapy, such as imatinib, commonly known as Gleevec. […] Another targeted medication called pazopanib blocks multiple kinase proteins associated with the formation of blood vessels in tumors and may be useful in treating some advanced soft tissue sarcomas.

• #1 Treatment of Soft Tissue Sarcomas, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/by-stage.html

  For all stage II and III sarcomas, removing the tumor with surgery is the main treatment. Lymph nodes will also be removed if they might contain cancer. Radiation may be given after surgery. […] The goal of treatment is to shrink the tumor, making it easier to remove. Chemo, radiation, or both might also be given after surgery. These treatments lower the chance of the tumor coming back in or near the same place it started. […] For people whose primary tumor and all metastases cannot be removed completely by surgery, radiation therapy and/or chemotherapy are often used. The chemo drugs doxorubicin and ifosfamide are often the first choice either together or along with other drugs. […] For some types of soft tissue sarcomas, treatment with newer targeted drugs or immunotherapy might also be an option.

• #1 Soft Tissue Sarcoma Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq

  Local control of high-grade soft tissue sarcomas of the trunk and the head and neck can be achieved with surgery in combination with radiation therapy. […] Effective treatment of retroperitoneal sarcomas requires removal of all gross disease while sparing adjacent viscera not invaded by tumor. […] In the setting of distant metastasis, surgery may be associated with long-term disease-free survival (DFS) in patients with pulmonary metastasis and optimal underlying disease biology. […] Radiation plays an important role in limb-sparing therapy. Pre- and postoperative radiation therapy has been shown to decrease the risk of local recurrence. […] The role of adjuvant chemotherapy remains controversial. […] The addition of ifosfamide (with mesna) to doxorubicin increases response rates and progression-free survival (PFS), but it has not been shown to improve overall survival (OS).

• #1 Treatment options | Soft tissue sarcoma | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/soft-tissue-sarcoma/treatment/treatment-options-for-soft-tissue-sarcoma

  Some people might have chemotherapy before surgery. This is called neoadjuvant chemotherapy. It aims to shrink the cancer and make it easier to remove with surgery. […] People with a type of sarcoma called a gastrointestinal stromal tumour (GIST) may have targeted cancer drugs such as imatinib (Glivec), sunitinib (Sutent), and regorafenib (Stivarga). […] The main treatment for soft tissue sarcoma is surgery. You may also have radiotherapy treatment to reduce the symptoms and help you feel better. A team of doctors and other professionals discuss the best treatment and care for you.

• #1 Soft Tissue Sarcoma Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq

  Doxorubicin has been the standard systemic therapy in managing metastatic soft tissue sarcoma for several decades. […] The combination of gemcitabine and docetaxel is used as second-line therapy in treating patients with soft tissue sarcoma. […] Single-agent chemotherapy may be used with other single agents for disease recurrence. […] The U.S. Food and Drug Administration (FDA) has approved eribulin, trabectedin, and pazopanib for the treatment of soft tissue sarcomas after failure of a first-line chemotherapy regimen. […] Immune checkpoint inhibitor therapy has shown some activity in selected soft tissue sarcoma subtypes, but their use cannot be routinely recommended.

• #1 FDA Approves First Engineered Cell Therapy for Treating Rare Sarcoma | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/news/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas

  Dr. Sandra D’Angelo is focused on developing immunotherapy treatments for soft tissue sarcoma. […] The U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called synovial sarcoma. […] This treatment offers an important new option for people with this rare cancer, Dr. DAngelo says. […] Sarcoma in general, and synovial sarcoma in particular, is a type of cancer where more treatments are desperately needed, Dr. DAngelo explains. […] Afami-cel is an engineered cell therapy, similar to the CAR T treatments that have been approved for treating certain blood cancers since 2017. […] The cancer-causing protein that afami-cel targets is called MAGE-A4.

• #1 Soft Tissue Sarcoma Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65773/

  Treatment for soft tissue sarcoma may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment of stage I soft tissue sarcoma may include the following: Surgery to remove the tumor, such as Mohs microsurgery for small sarcomas of the skin, wide local excision, or limb-sparing surgery. […] Treatment of stage II soft tissue sarcoma and stage III soft tissue sarcoma that has not spread to lymph nodes may include the following: Surgery to remove the tumor, such as wide local excision or limb-sparing surgery. […] Treatment of stage IV soft tissue sarcoma may include the following: Chemotherapy, Surgery to remove cancer that has spread to the lungs, Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib). […] Treatment of recurrent soft tissue sarcoma may include the following: Surgery (wide local excision) with or without radiation therapy, Surgery (amputation; rarely done), Surgery to remove cancer that has recurred in the lungs, Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib), Chemotherapy, A clinical trial of an immune checkpoint inhibitor (pembrolizumab, nivolumab, or ipilimumab).

• #1 Soft Tissue Sarcoma Treatment – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/patient/adult-soft-tissue-treatment-pdq

  Treatment of stage II soft tissue sarcoma and stage III soft tissue sarcoma that has not spread to lymph nodes may include the following: Surgery to remove the tumor, such as wide local excision or limb-sparing surgery. […] Treatment of stage III soft tissue sarcoma that has spread to lymph nodes (advanced) may include the following: Surgery (wide local excision) with lymphadenectomy. […] Treatment of stage IV soft tissue sarcoma may include the following: Chemotherapy. Surgery to remove cancer that has spread to the lungs. Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib). […] Treatment of recurrent soft tissue sarcoma may include the following: Surgery (wide local excision) with or without radiation therapy.

• #1 Treatments for stages 2 and 3 soft tissue sarcoma | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/soft-tissue-sarcoma/treatment/stage-2-and-3

  The following are treatment options for stages 2 and 3( localized and high-grade) soft tissue sarcoma. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. […] Surgery is the main treatment for stage 2 and stage 3 soft tissue sarcomas. A wide local excision is done to remove the tumour along with some normal tissue around it (surgical margin). If needed, limb-sparing surgery can be used for soft tissue sarcoma in an arm or a leg. […] Radiation therapy is usually offered for stage 2 and stage 3 soft tissue sarcomas. External radiation therapy is most often used. […] You may be offered chemotherapy for stage 2 and stage 3 soft tissue sarcomas. It is used to help lower the risk of the cancer coming back and prevent it from spreading. It is also used to help shrink the tumour before surgery. […] If surgery cant be done, chemotherapy may be added to radiation therapy to control the growth of the tumour. Sometimes this treatment can make surgery possible.

• #1 Sarcoma Treatment Options – Virginia Oncology

  https://www.virginiacancer.com/sarcoma/treatment-options/

  Some of the options that may be offered by your doctor are as follows: […] Stage I Sarcoma: Surgery (wide local excision, limb-sparing surgery, or Mohs microsurgery). Radiation therapy before and/or after surgery. […] Stages II and III adult soft tissue sarcoma treatments include: Surgery (wide local excision). Surgery (wide local excision) with radiation therapy, for large tumors. High-dose radiation therapy for tumors that cannot be removed by surgery. Radiation therapy or chemotherapy before limb-sparing surgery. Radiation therapy may also be given after surgery. A clinical trial of surgery followed by chemotherapy, for large tumors. […] Stage IV adult soft tissue sarcoma: If the disease has spread to the lymph nodes, treatment may include the following treatments: Surgery (wide local excision) with or without lymphadenectomy. Radiation therapy may also be given after surgery. Radiation therapy before and after surgery. A clinical trial of surgery followed by chemotherapy.

• #1 Treating Soft Tissue Sarcomas | Soft Tissue Sarcoma Treatments | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating.html

  Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the-art cancer treatment. […] You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors havent mentioned. […] Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision. […] Whether you are thinking about treatment, getting treatment, or not being treated at all, you can still get supportive care to help with pain or other symptoms. […] For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. […] Remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms.

• #1 Soft Tissue Sarcoma: Symptoms, Causes, Diagnosis, Treatment

  https://www.webmd.com/cancer/soft-tissue-sarcoma

  As with any type of cancer, it could come back. Doctors call that recurrent soft tissue sarcoma. Your treatment for a recurrence would depend on whether it comes back in the same place or if it shows up in other parts of your body. Just like with the first time, the options might include surgery, chemotherapy, radiation therapy, or brachytherapy. […] You can ask your doctor if there is a clinical trial for your type of sarcoma. These test new ways of treating cancer.

• #1 New strategies in soft tissue sarcoma treatment | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01580-3

  Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments. Traditionally anchored by anthracycline-based chemotherapy, the landscape of STS treatment hasn’t shifted dramatically in the past twenty years. However, recent strides in research are starting to paint a more hopeful picture. Leveraging advanced molecular profiling, researchers are now tailoring treatments to the unique genetic makeup of tumors, with targeted therapies showing promise. Innovations such as NTRK inhibitors for NTRK-rearranged sarcomas and gamma-secretase inhibitors for desmoid tumors are changing clinical practices. The rise of immunotherapy, including novel agents like LAG-3 inhibitors and bifunctional proteins that target both TGF- and PD-L1, offers new avenues for treatment, particularly when combined with traditional therapies like chemotherapy. Meanwhile, the approval of epigenetic treatments for specific sarcoma subtypes heralds a new wave of strategy based on histological specificity, which could lead to more personalized and effective care. While challenges remain, the field of STS treatment is evolving, driven by a deeper understanding of the disease’s biological underpinnings and a commitment to innovative research approaches.

• #1 Soft tissue sarcomas | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/soft-tissue-sarcomas/

  But there is a possibility youll have some difficulty using the part of the body that is operated on after surgery and sometimes reconstructive plastic surgery may be needed to repair significant damage. […] Radiotherapy is often used after surgery to destroy any remaining cancer cells. […] Radiotherapy may also sometimes be used before surgery to make a tumour easier to remove, or as part of your treatment to reduce your symptoms if surgery is not possible. […] Like radiotherapy, chemotherapy is sometimes used before surgery to shrink a tumour and make it easier to remove. […] Chemotherapy may also be used alone or alongside radiotherapy for soft tissue sarcomas that cannot be surgically removed. […] A cure is not usually possible if a soft tissue sarcoma is only detected at a late stage when it has already spread to other parts of the body, although treatment can help slow the spread of the cancer and control your symptoms.

• #1 Treatment of Soft Tissue Sarcomas, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/by-stage.html

  The best chance to cure a soft tissue sarcoma is to remove it with surgery, so surgery is part of the treatment for all soft tissue sarcomas whenever possible. It’s important that your surgeon and other doctors are experienced in the treatment of sarcomas. These tumors are hard to treat and require both experience and expertise. Studies have shown that people with sarcomas tend to have better outcomes when they’re treated at specialized cancer centers that have experience in sarcoma treatment. […] Treatment is generally similar for most types of soft tissue sarcoma, especially for earlier stage sarcomas. But in recent years, as doctors have learned more about the differences between the types, newer targeted therapy and immunotherapy drugs have become important treatment options for some types of advanced soft tissue sarcomas.

• #1 Soft Tissue Sarcoma | Symptoms & Cancer Treatment | MedStar Health

  https://www.medstarhealth.org/services/soft-tissue-sarcomas

  We offer the area’s most advanced and comprehensive care. Our team of sub-specialized physicians and advanced practice clinicians have years of experience treating people with these types of cancer. […] Our team of specialists discusses each case in bi-weekly tumor boards, where we can collectively recommend the best treatment recommendation. […] Patients with this type of sarcoma are often referred to a surgeon for evaluation. Because surgery is often the best way to remove these types of cancer, most patients will undergo a „wide resection,” during which the surgeon will remove the tumor and a layer of surrounding healthy tissue to minimize the risk of recurrence. […] When sarcoma impacts the arms or legs, we are experienced in performing limb-sparing surgery, which eliminates the need for amputation in more than 95 percent of patients.

• #1 Soft Tissue Sarcoma | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/soft-tissue-sarcoma

  People with advanced soft tissue sarcoma may benefit from leading-edge therapies, such as immunotherapy or targeted therapy. These are often offered through clinical trials. MSK runs one of the largest soft tissue sarcoma clinical trial programs in the United States. […] Radiation therapy is another important part of care for some people with soft tissue sarcoma. Radiation may be given before surgery to shrink a tumor or after surgery to reduce the chances that a tumor will come back. MSKs radiation oncologists have special training in caring for people with soft tissue tumors.

• #1 Soft Tissue Sarcoma: Treatment Introduction

  https://encyclopedia.nm.org/Conditions/Cancer/34,17569-1

  Researchers are always looking for new ways to treat soft tissue sarcoma. These new methods are tested in clinical trials. […] At first, thinking about treatment choices may seem overwhelming. Talk with your healthcare providers, nurses, and loved ones. Make a list of questions. Consider the benefits and side effects of each choice. Talk about your concerns with your healthcare provider before making a decision.

• #1 Guidelines for the Management of Soft Tissue Sarcomas

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2903951/

  These guidelines were drawn up following a consensus meeting of UK sarcoma specialists convened under the auspices of the British Sarcoma Group and are intended to provide a framework for the multidisciplinary care of patients with soft tissue sarcomas. […] Any patient with a suspected soft tissue sarcoma should be referred to a diagnostic centre and managed by a specialist sarcoma multidisciplinary team. Surgical excision followed by post operative radiotherapy is the standard management of high grade limb sarcomas although occasionally amputation remains the only option. Pre-operative treatment with chemotherapy or radiotherapy should be considered for patients with borderline resectable tumours. Isolated limb perfusion may permit limb salvage in some cases where amputation is the only other option. Adjuvant chemotherapy is not routinely recommended but may be considered in certain specific situations. Regular follow up is recommended to assess local control and the development of metastatic disease. Single agent doxorubicin is the standard first line therapy for metastatic disease. Ifosfamide is an alternative if anthracyclines are contraindicated. Combination therapy may be considered in individual patients. Second line agents include ifosfamide, dacarbazine, trabectedin and the combination of gemcitabine + docetaxel. Surgical resection of local recurrence and pulmonary metastases should be considered in individual patients.

• #1 Management of soft-tissue sarcomas; treatment strategies, staging, and outcomes | SICOT-J

  https://www.sicot-j.org/articles/sicotj/full_html/2017/01/sicotj160134/sicotj160134.html

  Following limb-salvage surgery or amputation, patients may be left with significant physical and emotional disability and reduced overall quality of life (QOL). […] The majority of local recurrences as well as lung metastases will become evident within the first two years following treatment. […] Following a tissue diagnosis and staging, the treatment of patients with STS involves a multidisciplinary team approach and most patients are eligible for limb-salvage surgery, usually combined with radiation. Following treatment the majority of patients can expect a painless and functional extremity.

• #2 Soft tissue sarcoma – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/soft-tissue-sarcoma/diagnosis-treatment/drc-20377730

  Tests and procedures used to diagnose soft tissue sarcoma include imaging tests and procedures to remove a sample of cells for testing. […] Treatment options for soft tissue sarcoma will depend on the size, type and location of the cancer. […] Surgery is a common treatment for soft tissue sarcoma. During surgery, the surgeon usually removes the cancer and some healthy tissue around it. […] Soft tissue sarcoma often affects the arms and legs. In the past, surgery to remove an arm or leg was common. Today, other approaches are used, when possible. For example, radiation and chemotherapy might be used to shrink the cancer. That way the cancer can be removed without needing to remove the entire limb. […] Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons and other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to specific points on your body.

• #2 5 Innovative Soft Tissue Sarcoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/soft-tissue-sarcoma/soft-tissue-sarcoma-treatment.html

  Soft tissue sarcomas usually are treated with a combination of therapies that may include surgery, chemotherapy and radiation. If you are diagnosed with sarcoma, your doctor will discuss the best options to treat it. This depends on several factors, including: […] Your treatment for sarcoma will be customized to your particular needs and may include one or more of the treatment types listed below. […] Surgery is the main treatment for soft-tissue sarcomas. The surgeon removes the tumor, as well as a margin of healthy tissue around it to take out as many cancer cells as possible. You may receive chemotherapy or radiation therapy before or after the surgery. […] MD Anderson offers the most up-to-date and advanced chemotherapy options. Chemotherapy may be used as the main treatment for sarcoma or with surgery or radiation. A combination of two or more chemotherapy drugs may be used.

• #2 Benign and Malignant Soft-Tissue Tumors Treatment & Management: Approach Considerations, Medical Therapy, Surgical Therapy

  https://emedicine.medscape.com/article/1253816-treatment

  Complete local excision is adequate treatment for benign soft-tissue tumors. However, a variety of treatment options, including surgery alone or combined with radiation therapy or chemotherapy, may be considered for treatment of localized primary and recurrent sarcomas. […] Surgery is the most important component of any treatment plan for a clinically localized primary or recurrent soft-tissue sarcoma. […] An intracapsular excision or amputation passes within the tumor itself. […] In marginal excisions and amputation, the excision is performed through the pseudocapsule surrounding the tumor. […] In a wide excision, the tumor is excised with a wide margin of surrounding normal tissue but within the muscular compartment. […] Radical excisions are en-bloc excisions of the tumor along with the entire muscle compartment.

• #2 Surgery for Soft Tissue Sarcoma | NYU Langone Health

  https://nyulangone.org/conditions/soft-tissue-sarcoma/treatments/surgery-for-soft-tissue-sarcoma

  A team of surgical experts and other specialists at NYU Langone aid in managing these tumors. For example, if the tumor wraps around important blood vessels and nerves, vascular surgeons and neurosurgeons may join your cancer care team. […] After limb sparing surgery, doctors at NYU Langones Rusk Rehabilitation often prescribe a program of physical and occupational therapy to help restore function to the arm or leg, so that you can return as soon as possible to your usual activities. […] Our doctors at Rusk Rehabilitation can prescribe physical therapy, occupational therapy, and other rehabilitative techniques, as well as ongoing psychological support, to help you grow comfortable with the prosthetic as you return to your daily routine. […] Although rare, soft tissue sarcomas may occur in the head, the retroperitoneum (the area deep within the abdomen), the pelvic cavity, the uterus, the chest wall, or the gastrointestinal tract. These tumors are often managed with surgery but, as with other sarcomas, may also require radiation therapy or chemotherapy.

• #2 5 Innovative Soft Tissue Sarcoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/soft-tissue-sarcoma/soft-tissue-sarcoma-treatment.html

  Radiation therapy usually is not used as the main treatment for sarcoma, but it may be used before surgery to shrink the tumor or after surgery to destroy remaining cancer cells. […] Proton therapy delivers high radiation doses directly to the tumor site, sparing nearby healthy tissue and vital organs. For some patients, this therapy results in better cancer control with less impact on the body. […] Your doctor might request specific genomic or molecular profiling to help find therapies to fight the disease. […] MD Anderson is committed to providing you with the most advanced treatments for sarcoma with the least impact on your body. Your sarcoma treatment is customized specifically for you by one of the world’s foremost teams of experts. […] Statistics show that sarcoma patients have better outcomes when they are treated at large comprehensive cancer centers where specialized oncologists have more experience with the disease.

• #2 Soft tissue sarcoma

  https://www.cancervic.org.au/cancer-information/types-of-cancer/soft_tissue_cancers/soft-treatment.html

  Amputation is less common but can also occur. The most important thing is that you have your surgery done by an experienced surgeon working in a specialist centre for sarcoma. […] Radiation therapy (also known as radiotherapy) uses high energy rays to destroy cancer cells. […] Sarcoma is known to be very sensitive to radiation therapy. It may be used: before surgery, to destroy the cancer cells and create a rind around the cancer, which helps the surgeon to perform good surgery; if the cancer is too big to remove with surgery; if the cancer has spread to other parts of the body; after surgery, to destroy any remaining cancer cells and stop the cancer coming back; if the cancer is in a place in the body that is too hard to reach using surgery. […] Chemotherapy is the use of drugs to kill or slow the growth of cancer cells.

• #2 Treatment of Soft Tissue Sarcomas, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/by-stage.html

  The best chance to cure a soft tissue sarcoma is to remove it with surgery, so surgery is part of the treatment for all soft tissue sarcomas whenever possible. It’s important that your surgeon and other doctors are experienced in the treatment of sarcomas. These tumors are hard to treat and require both experience and expertise. Studies have shown that people with sarcomas tend to have better outcomes when they’re treated at specialized cancer centers that have experience in sarcoma treatment. […] Treatment is generally similar for most types of soft tissue sarcoma, especially for earlier stage sarcomas. But in recent years, as doctors have learned more about the differences between the types, newer targeted therapy and immunotherapy drugs have become important treatment options for some types of advanced soft tissue sarcomas.

• #2

  https://winshipcancer.emory.edu/cancer-types-and-treatments/sarcoma/treatment.php

  It is sometimes used in conjunction with chemotherapy. […] Proton therapy is often used in the treatment of chordomas and chondrosarcomas, as well as many other types of soft tissue sarcomas. […] Immunotherapies, which involve the use of medications to enhance the body’s natural defenses to target and attack specific types of cancer cells, have been highly effective in treating certain solid cancers and leukemias. […] In addition to these sarcoma treatment guidelines, participating in clinical trials may be an option. […] Winship also offers a supportive oncology team of specialized doctors and nurses who can help with the physical, psychological and emotional aspects of living with cancer, including symptom management and counseling.

• #2 Soft Tissue Sarcoma Treatment Protocols: Treatment Protocols

  https://emedicine.medscape.com/article/2007168-overview

  Negative aspects of this therapy include increased wound-healing complications. […] If margins are close (1 cm) or positive, consider boost with brachytherapy, intraoperative radiation therapy (IORT), or postoperative EBRT/intensity-modulated radiation therapy (IMRT) at doses ranging from 10-26 GY. […] In metastatic disease, it is important to differentiate between limited and disseminated metastases. […] Limited metastasis involves only one organ and should be considered for resection for improved disease-free survival (DFS) and overall survival (OS). […] Disseminated metastases can be managed with palliative therapy (radiation, chemotherapy, surgery, or supportive care alone). […] Adjuvant chemotherapy (in patients without metastasis and after surgical resection of a primary tumor) is not generally considered as first-line therapy.

• #2 Soft Tissue Sarcoma Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq

  Local control of high-grade soft tissue sarcomas of the trunk and the head and neck can be achieved with surgery in combination with radiation therapy. […] Effective treatment of retroperitoneal sarcomas requires removal of all gross disease while sparing adjacent viscera not invaded by tumor. […] In the setting of distant metastasis, surgery may be associated with long-term disease-free survival (DFS) in patients with pulmonary metastasis and optimal underlying disease biology. […] Radiation plays an important role in limb-sparing therapy. Pre- and postoperative radiation therapy has been shown to decrease the risk of local recurrence. […] The role of adjuvant chemotherapy remains controversial. […] The addition of ifosfamide (with mesna) to doxorubicin increases response rates and progression-free survival (PFS), but it has not been shown to improve overall survival (OS).

• #2 Medications for Soft Tissue Sarcoma | NYU Langone Health

  https://nyulangone.org/conditions/soft-tissue-sarcoma/treatments/medications-for-soft-tissue-sarcoma

  Chemotherapy given before surgery, also called neoadjuvant chemotherapy, may be used to shrink large tumors, making surgery a more feasible, safe, and successful option. This approach also reduces the need for amputation of a limb and lessens the risk of the cancer coming back. Chemotherapy, on occasion, may be given after surgery to destroy tumor cells that have spread to other parts of the body. […] Based on the subtype of soft tissue sarcoma, your doctor may prescribe targeted medications as part of your treatment. […] For example, gastrointestinal stromal tumor sarcoma may respond to targeted therapy, such as imatinib, commonly known as Gleevec. […] Another targeted medication called pazopanib blocks multiple kinase proteins associated with the formation of blood vessels in tumors and may be useful in treating some advanced soft tissue sarcomas.

• #2 Soft Tissue Sarcoma Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65773/

  Treatment for soft tissue sarcoma may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment of stage I soft tissue sarcoma may include the following: Surgery to remove the tumor, such as Mohs microsurgery for small sarcomas of the skin, wide local excision, or limb-sparing surgery. […] Treatment of stage II soft tissue sarcoma and stage III soft tissue sarcoma that has not spread to lymph nodes may include the following: Surgery to remove the tumor, such as wide local excision or limb-sparing surgery. […] Treatment of stage IV soft tissue sarcoma may include the following: Chemotherapy, Surgery to remove cancer that has spread to the lungs, Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib). […] Treatment of recurrent soft tissue sarcoma may include the following: Surgery (wide local excision) with or without radiation therapy, Surgery (amputation; rarely done), Surgery to remove cancer that has recurred in the lungs, Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib), Chemotherapy, A clinical trial of an immune checkpoint inhibitor (pembrolizumab, nivolumab, or ipilimumab).

• #2 Soft Tissue Sarcoma Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq

  Doxorubicin has been the standard systemic therapy in managing metastatic soft tissue sarcoma for several decades. […] The combination of gemcitabine and docetaxel is used as second-line therapy in treating patients with soft tissue sarcoma. […] Single-agent chemotherapy may be used with other single agents for disease recurrence. […] The U.S. Food and Drug Administration (FDA) has approved eribulin, trabectedin, and pazopanib for the treatment of soft tissue sarcomas after failure of a first-line chemotherapy regimen. […] Immune checkpoint inhibitor therapy has shown some activity in selected soft tissue sarcoma subtypes, but their use cannot be routinely recommended.

• #2 Current Treatment Landscape of Soft Tissue Sarcoma

  https://www.onclive.com/view/current-treatment-landscape-of-soft-tissue-sarcoma

  We can go on and talk about where we are right now with the treatment or management of soft tissue sarcomas and GISTs [gastrointestinal stromal tumors]. […] In general terms, when I see a patient with metastatic or inoperable soft tissue sarcoma, lets say an unclassified pleomorphic sarcoma, if theyre young and otherwise healthy, with no substantial comorbidities, my general regimen is doxorubicin plus ifosfamide. […] Combination chemotherapy is really what we recommend if the patient is otherwise healthy. […] I think your point about the patients with oligometastasis or patients with locally advanced disease, if we can shrink the tumor enough, they may be eligible for surgery, or they may be eligible for radiation therapy or ablative procedures to render them disease free. […] All the retrospective, even though its retrospective data with surgery, they have shown that patients with limited progression or with patients who are even responding or doing well, but they have residual disease, could derive benefit from being rendered NED [no evidence of disease] by surgery.

• #2 Soft tissue sarcoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/soft-tissue-sarcoma

  Radiotherapy uses high-energy rays to destroy cancer cells. Radiotherapy may be given before surgery to shrink the cancer, or after surgery, to destroy any remaining cancer cells. It can also be used to relieve symptoms and control sarcoma that has spread or come back. Rarely, when surgery is not possible, it is used on its own. […] Chemotherapy uses anti-cancer (cytotoxic) drugs to destroy cancer cells. Not everyone has chemotherapy. It depends on the type of sarcoma and the risk of it coming back. It may be given after or before surgery. Chemotherapy can also be given to relieve symptoms and to control sarcoma that cannot be completely removed or has spread. […] Targeted therapy uses drugs to find and attack cancer cells. There are different types of targeted therapy, including tyrosine kinase inhibitors (TKIs). Imatinib is a TKI that is often used to treat gastrointestinal stromal tumour (GIST). Some other targeted therapy drugs might be used in some situations to help to control soft tissue sarcoma.

• #2 Soft Tissue Sarcoma Symptoms, Facts, Diagnosis, and Treatment | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/soft-tissue-sarcoma.html

  As one of the world’s leading sarcoma research centers, we helped pioneer many advancements used around the world, including: New ways to combine therapies, including surgery, chemotherapy or radiation therapy, to be more successful, Advanced chemotherapy agents and novel delivery methods that have less impact on the body, Limb-sparing surgery that can help preserve arms and legs in many cases, Medicines to fight cancer on a molecular level, Ways to deliver more intense chemotherapy. […] The Sarcoma Center at MD Anderson.

• #2 Sarcoma: What it Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17934-sarcoma

  Chemotherapy uses drugs that kill or slow the growth of rapidly multiplying cancer cells. […] Targeted therapy attacks weaknesses in cancer cells without harming healthy cells in the process. […] Immunotherapy strengthens your immune system so that its better able to identify and fight cancer cells. […] Palliative care is specialized medical care for people with serious illnesses, including cancer. […] Your healthcare provider may also recommend you take part in a clinical trial. A clinical trial is a study that tests the safety and effectiveness of new cancer treatments. New treatments for sarcoma are always in process. A clinical trial may be an option for you, depending on your diagnosis.

• #2 FDA Approves First Engineered Cell Therapy for Treating Rare Sarcoma | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/news/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas

  The phase 2 clinical trial that resulted in the drugs approval was published in The Lancet in April 2024. […] These findings are significant for a group of patients who have largely exhausted other treatment options, Dr. DAngelo says. […] Afami-cel and other TCR therapies are also being studied in pediatric sarcomas.

• #2 Soft Tissue Sarcoma Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq

  Treatment options for soft tissue sarcoma include: […] Complete staging and treatment planning by a multidisciplinary team of cancer specialists is required to determine the optimal treatment for patients with soft tissue sarcoma. In most cases, a combined modality approach of preoperative radiation therapy (preRT) or postoperative radiation therapy (PORT) is used for treatment, rather than a radical surgical procedure such as amputation. Surgery without PORT may be possible in selected cases. The role of chemotherapy is not well defined. […] Surgical resection is the mainstay of therapy for soft tissue sarcomas. […] In some small low-grade tumors of the extremities or trunk, surgery alone can be performed without the use of radiation. […] When feasible, wide-margin function-sparing surgical excision is the cornerstone of effective treatment for extremity tumors.

• #2 Treatments for soft tissue sarcoma | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/soft-tissue-sarcoma/treatment

  If you have soft tissue sarcoma, your healthcare team will create a treatment plan just for you. It will be based on your health and specific information about the cancer. When deciding which treatments to offer for soft tissue sarcoma, your healthcare team will consider: […] The care and treatment of people with soft tissue sarcoma is often done by a healthcare team that is experienced in dealing with soft tissue sarcoma. Most cases of soft tissue sarcoma need to be managed by many specialists, including a radiologist, surgeon, medical oncologist and radiation oncologist. […] Surgery is usually the primary treatment for stage 1 soft tissue sarcoma. […] Surgery is usually the primary treatment for stage 2 and 3 soft tissue sarcomas. […] Stage 4 soft tissue sarcoma can be treated with a combination of therapies, including chemotherapy, radiation and surgery.

• #2 Treatment of Soft Tissue Sarcomas, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/by-stage.html

  For all stage II and III sarcomas, removing the tumor with surgery is the main treatment. Lymph nodes will also be removed if they might contain cancer. Radiation may be given after surgery. […] The goal of treatment is to shrink the tumor, making it easier to remove. Chemo, radiation, or both might also be given after surgery. These treatments lower the chance of the tumor coming back in or near the same place it started. […] For people whose primary tumor and all metastases cannot be removed completely by surgery, radiation therapy and/or chemotherapy are often used. The chemo drugs doxorubicin and ifosfamide are often the first choice either together or along with other drugs. […] For some types of soft tissue sarcomas, treatment with newer targeted drugs or immunotherapy might also be an option.

• #2 Soft Tissue Sarcoma | UCSF Department of Surgery

  https://surgery.ucsf.edu/condition/soft-tissue-sarcoma

  Treatment of stage IV soft tissue sarcoma may include the following: Chemotherapy. Surgery to remove cancer that has spread to the lungs. Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib). […] Treatment of recurrent soft tissue sarcoma may include the following: Surgery (wide local excision) with or without radiation therapy. Surgery (amputation; rarely done). Surgery to remove cancer that has recurred in the lungs. Targeted therapy with a tyrosine kinase inhibitor (pazopanib or imatinib). Chemotherapy. A clinical trial of an immune checkpoint inhibitor (pembrolizumab, nivolumab, or ipilimumab).

• #2 Treatment of Soft Tissue Sarcomas, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/by-stage.html

  If the sarcoma comes back in the same area where it started, it may be treated with surgery. Radiation therapy may be given after surgery, especially if radiation wasn’t part of the treatment of the original tumor. If external beam radiation was used before, brachytherapy may still be an option. […] If the sarcoma returns in a distant part of the body, chemo, targeted therapy, or immunotherapy drugs may be options.

• #2 New strategies in soft tissue sarcoma treatment | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01580-3

  The standard first-line treatment for these cancers involves anthracycline-based regimens, which are used across nearly all subtypes and result in a median progression-free survival (mPFS) of approximately six months. Upon disease progression, second-line treatments such as gemcitabine, dacarbazine, ifosfamide, eribulin, and pazopanib are selected based on tumor histotype, contributing to an average median overall survival (mOS) of 20 months. […] This review aims to provide a comprehensive overview of the latest advancements in systemic therapies for STS, including chemotherapies, targeted agents, and immunotherapies, with the ultimate goal of enhancing patient survival. […] The innovative aspect of ADCs lies in their ability to exploit the natural properties of antibodies to seek out and bind to specific antigens expressed on the surface of cancer cells.

• #2 Soft tissue sarcoma

  https://www.cancervic.org.au/cancer-information/types-of-cancer/soft_tissue_cancers/soft-treatment.html

  Your treatment will depend on your situation and the type of sarcoma you have. It may also be used to help stop a sarcoma coming back after surgery. […] Most often chemotherapy is given through a drip into a vein (intravenously) or as a tablet that is swallowed. […] People with soft tissue sarcomas may be offered targeted therapies such as pazopanib (Votrient) to slow the growth of the tumour. […] Complementary therapies are designed to be used alongside conventional medical treatments and can increase your sense of control, decrease stress and anxiety, and improve your mood. […] If the cancer does come back, treatment will depend on where the cancer has returned in your body and may include a mix of surgery, chemotherapy and radiation therapy. […] In some cases of advanced cancer, treatment will focus on managing any symptoms, such as pain, and improving your quality of life without trying to cure the disease. This is called palliative treatment and it can be provided in the home, in a hospital, in a palliative care unit or hospice.

• #2 Soft Tissue Sarcoma | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/rare-cancers/soft-tissue-sarcoma

  Targeted therapy is a cancer treatment that uses drugs to target specific genes and proteins that are involved in the growth and survival of cancer cells. […] In some cases of soft tissue sarcoma, your medical team may talk to you about palliative care. Palliative care aims to improve your quality of life by alleviating symptoms of cancer without trying to cure the disease. […] Treatment may include radiotherapy, chemotherapy or other drug therapies.

• #2 Soft Tissue Sarcoma Treatment Program | Massachusetts General Hospital

  https://www.massgeneral.org/cancer-center/treatments-and-services/sarcoma/soft-tissue-sarcoma

  Our surgeons are experienced in resecting tumors and reconstructing defects. […] We are active participants in a national clinical trials network that allows us to bring new treatments to our patients as quickly as possible. […] Your care team may include: […] Medical and/or pediatric oncologists design the most appropriate combination of chemotherapy, immunotherapy, and/or targeted therapy for your particular cancer. […] Depending on the stage and other characteristics of your cancer, the treatment may include surgery, chemotherapy, radiation therapy, or a combination of these therapies. […] We offer the full range of chemotherapeutic agents, including angiogenesis inhibitors and molecularly targeted agents to treat patients with the over 50 sub-types of sarcoma. […] Our orthopaedic oncology and spine surgeons are expert in the most advanced techniques, including computer-navigated surgery.

• #2 Treatment for Sarcoma | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/diseases/sarcoma/treatment.html

  Sarcoma is often hard to treat, so its important to receive care at a specialized center with sarcoma expertise. At Fred Hutchinson Cancer Center, our experts offer multidisciplinary, team-based soft tissue sarcoma treatment as well as bone cancer treatment, including advanced therapies and new options that are only available through clinical trials. […] Sarcoma treatment at Fred Hutch is customized for each patients needs. […] Your Fred Hutch physician works together with a group of other sarcoma specialists. They include medical oncologists, radiation oncologists, surgeons and researchers who are looking for better ways to treat this disease. […] Every week, this team goes to a meeting called a tumor board. Together, dozens of team members discuss their patients treatment plans. This approach means each patient benefits from the experience of the whole group.

• #2 Treating Soft Tissue Sarcomas | Soft Tissue Sarcoma Treatments | American Cancer Society

  https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating.html

  Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the-art cancer treatment. […] You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors havent mentioned. […] Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision. […] Whether you are thinking about treatment, getting treatment, or not being treated at all, you can still get supportive care to help with pain or other symptoms. […] For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. […] Remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms.

• #2 Soft Tissue Sarcoma Treatment Program | Massachusetts General Hospital

  https://www.massgeneral.org/cancer-center/treatments-and-services/sarcoma/soft-tissue-sarcoma

  Our radiation oncologists offer a range of therapies designed to shrink and destroy tumors while protecting normal tissue. […] Research conducted at Massachusetts General Hospital Cancer Center and other cancer centers is leading to better understanding of the genetic basis of soft tissue sarcomas. […] Through our clinical trials program, we are able to offer many new, investigational medications for appropriately selected patients.

• #2 Management of soft-tissue sarcomas; treatment strategies, staging, and outcomes | SICOT-J

  https://www.sicot-j.org/articles/sicotj/full_html/2017/01/sicotj160134/sicotj160134.html

  Following limb-salvage surgery or amputation, patients may be left with significant physical and emotional disability and reduced overall quality of life (QOL). […] The majority of local recurrences as well as lung metastases will become evident within the first two years following treatment. […] Following a tissue diagnosis and staging, the treatment of patients with STS involves a multidisciplinary team approach and most patients are eligible for limb-salvage surgery, usually combined with radiation. Following treatment the majority of patients can expect a painless and functional extremity.

• #2 Treatment for Sarcoma | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/diseases/sarcoma/treatment.html

  We update your treatment plan based on the best scientific evidence as well as how your disease responds and what you prefer. […] You may be wondering about possible side effects from treatment, like hair loss or nausea from chemotherapy. […] If the person you are caring for is having surgery or getting treatments like chemotherapy, targeted therapy, immunotherapy, proton therapy or radiation therapy, there are many ways you can help. […] Along with treating your sarcoma, Fred Hutch provides a range of services to support you and your caregiver before, during and after treatment. […] When your disease is in remission and your active treatment ends, it is still important to get follow-up care on a regular basis. […] Our Sarcoma Surveillance Clinic offers monitoring for patients who are done with their sarcoma treatment.

• #3 UK guidelines for the management of soft tissue sarcomas | British Journal of Cancer

  https://www.nature.com/articles/s41416-024-02674-y

  Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues and can occur almost anywhere in the body. […] This makes it more important that STS are managed by expert multidisciplinary teams, to ensure consistent and optimal treatment, recruitment to clinical trials, and the ongoing accumulation of further data and knowledge. […] In the UK, any patient with a suspected soft tissue sarcoma should be referred to a specialist regional soft tissues sarcoma service, to be managed by a specialist sarcoma multidisciplinary team. Once the diagnosis has been confirmed using appropriate imaging and a tissue biopsy, the main modality of management is usually surgical excision performed by a specialist surgeon, combined with pre- or post-operative radiotherapy for tumours at higher risk for local recurrence. Systemic anti-cancer therapy (SACT) may be utilised in cases where the histological subtype is considered more sensitive to systemic treatment. Regular follow-up is recommended to assess local control, development of metastatic disease, and any late effects of treatment.

• #3 5 Innovative Soft Tissue Sarcoma Treatment Options | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/soft-tissue-sarcoma/soft-tissue-sarcoma-treatment.html

  Soft tissue sarcomas usually are treated with a combination of therapies that may include surgery, chemotherapy and radiation. If you are diagnosed with sarcoma, your doctor will discuss the best options to treat it. This depends on several factors, including: […] Your treatment for sarcoma will be customized to your particular needs and may include one or more of the treatment types listed below. […] Surgery is the main treatment for soft-tissue sarcomas. The surgeon removes the tumor, as well as a margin of healthy tissue around it to take out as many cancer cells as possible. You may receive chemotherapy or radiation therapy before or after the surgery. […] MD Anderson offers the most up-to-date and advanced chemotherapy options. Chemotherapy may be used as the main treatment for sarcoma or with surgery or radiation. A combination of two or more chemotherapy drugs may be used.

• #3 Soft Tissue Sarcoma Treatment | Sarcoma Care Team | Parkview Health

  https://www.parkview.com/medical-services/cancer/cancers-we-treat/soft-tissue-sarcoma

  Studies have demonstrated that combining surgical removal with radiation therapy for soft tissue sarcoma produces the best local control rates, minimizing local recurrence of soft tissue sarcomas. […] To maximize accuracy of radiation and minimize associated harm, we utilize Intensity Modulated Radiation Therapy (IMRT), which has been demonstrated in studies to result in optimal local control rates for soft tissue sarcomas. […] In some circumstances chemotherapy is utilized, depending upon sarcoma subtype, grade, anatomic location, feasibility of surgical resection, and the presence of metastatic disease. […] At the Parkview Cancer Institute, we utilize multi-agent chemotherapy and immunotherapy for soft tissue sarcoma treatment depending upon clinical scenarios. […] Surgical treatment requires a wide excision, meaning the tumor is removed covered with a barrier of normal tissue to minimize the risk of leaving microscopic cancer cells in the body. Greater than 90% of sarcoma cases can be treated with limb-sparing surgery, avoiding amputation, and thus optimizing function after tumor removal.

• #3 Soft Tissue Sarcoma Treatment | Sarcoma Care Team | Parkview Health

  https://www.parkview.com/medical-services/cancer/cancers-we-treat/soft-tissue-sarcoma

  Soft tissue sarcomas are a rare group of cancers arising from connective tissue such as muscle, fat, nerves, bone and vascular tissue, that can occur at any age. […] At the Parkview Cancer Institute we have a dedicated Sarcoma Care Team including radiation oncology, medical oncology, interventional radiology, pathology, plastic surgery, nurse navigation, genetics, nutrition, spiritual support, and financial support, led by our orthopedic oncologic surgeon. […] Treatment plans are derived from tumor anatomic location, sarcoma subtype, tumor grade and staging. In general, soft tissue sarcomas are often treated with radiation and surgery for tumor removal and local control. […] At the Parkview Cancer Institute, preoperative radiation therapy is often utilized as it requires lower radiation doses thus minimizing the adverse effects of radiation.

• #3 Soft Tissue Sarcoma Treatment Protocols: Treatment Protocols

  https://emedicine.medscape.com/article/2007168-overview

  Prevention of local recurrence may require additional radiation and/or chemotherapy. […] When possible, patients should be referred to an NCCN-designated center and enrolled in clinical trials. […] Tazemetostat is a first-in-class enhancer of zeste homolog 2 (EZH2) inhibitor indicated for patients aged 16 y or older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. […] A phase II study randomized patients with leiomyosarcomas to gemcitabine alone or gemcitabine and docetaxel and reported higher response rates in the dual chemotherapy arm. […] Several phase II trials have demonstrated the activity of temozolomide in sarcoma, with efficacy particularly notable in leiomyosarcoma. […] Treatment is wide excision and irradiation; however, angiosarcoma is highly aggressive and has a propensity for local recurrence, multifocal spread, and early hematogenous dissemination. […] Systemic treatment of angiosarcomas includes doxorubicin or ifosfamide, with responses in the range of 10-20%; angiosarcomas are also highly sensitive to taxanes. […] Chemosensitive disease with particular sensitivity to ifosfamide.

• #3 Targeted therapy for soft tissue sarcoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/targeted-therapies-for-soft-tissue-sarcoma

  Targeted therapy drugs interfere with the way that cancer cells grow. They are often given as part of research trials and are sometimes used as a treatment for soft tissue sarcomas. […] Targeted therapy uses drugs to find and attack cancer cells. There are many different types of targeted therapy, including tyrosine kinase inhibitors (TKIs). Each type targets something in or around the cancer cell that is helping it grow and survive. They may be used to help to treat gastrointestinal stromal tumours gastrointestinal stromal tumour (GIST) or to control soft tissue sarcoma that has spread. […] Targeted therapy drugs may be given as part of a research trial to treat soft tissue sarcoma. […] Imatinib is a TKI. It may be used to treat GISTs, or a rare type of soft tissue sarcoma called dermatofibrosarcoma protuberans.

• #3 FDA Approves First Engineered Cell Therapy for Treating Rare Sarcoma | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/news/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas

  Dr. Sandra D’Angelo is focused on developing immunotherapy treatments for soft tissue sarcoma. […] The U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called synovial sarcoma. […] This treatment offers an important new option for people with this rare cancer, Dr. DAngelo says. […] Sarcoma in general, and synovial sarcoma in particular, is a type of cancer where more treatments are desperately needed, Dr. DAngelo explains. […] Afami-cel is an engineered cell therapy, similar to the CAR T treatments that have been approved for treating certain blood cancers since 2017. […] The cancer-causing protein that afami-cel targets is called MAGE-A4.

• #3 New strategies in soft tissue sarcoma treatment | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01580-3

  The clinical potential of Mipa was explored in a Phase 1b trial involving patients with advanced sarcomas. […] These promising findings underscore the potential of immunotherapy as a more effective treatment option for certain sarcoma patients when compared to traditional cytotoxic chemotherapy. […] The study represents the first biomarker driven randomized investigation of an immunotherapy regimen in the first line setting for patients with advanced STS, and its results are eagerly anticipated in 2025. […] The compelling data from both therapeutic agents emphasize the necessity of routine genomic screening for NTRK fusions in sarcomas to tailor personalized treatment approaches that can significantly improve patient outcomes.

• #3 Soft Tissue Sarcoma

  https://www.mhs.net/services/cancer-care/conditions-treatments-and-services/sarcoma

  We dont let lingering sarcoma symptoms like pain or treatment side effects slow your recovery. Cancer support services, such as nutrition counseling, spiritual care and help from social workers, are available. Patient navigators (oncology nurses) are with you throughout treatment and help you access the support you need. […] We are one of the few programs in the region capable of treating sarcomas. You benefit from highly skilled specialists, many of whom have advanced training and decades of experience. We use leading care methods, giving you the best chances for healing. Highlights of our program include: […] Our multidisciplinary expertise means youre in caring and capable hands. The team includes surgeons, medical oncologists, radiation oncologists, radiologists and pathologists. We work together to deliver complete care, including an accurate diagnosis and appropriate therapies.

• #3 Benign and Malignant Soft-Tissue Tumors Treatment & Management: Approach Considerations, Medical Therapy, Surgical Therapy

  https://emedicine.medscape.com/article/1253816-treatment

  Management of soft-tissue tumors may evolve as a result of the advent of molecular diagnostics and antitumor therapies. […] Soft-tissue sarcomas are challenging lesions that demand a multidisciplinary and multimodality approach for proper clinical evaluation and treatment. […] Successful management of such lesions requires a multidisciplinary team of surgeons, radiologists, pathologists, medical oncologists, radiation oncologists, oncology nurses, rehabilitation therapists, and social workers. […] Because of the comparative rarity of soft-tissue sarcomas and a general lack of related medical expertise, patients with these tumors should be considered for referral, preferably during the initial evaluation phase, to medical centers experienced in sarcoma management. […] High-grade soft-tissue sarcomas often are treated with ifosfamide- and doxorubicin-based chemotherapy.

• #3 Soft Tissue Sarcoma | Symptoms & Cancer Treatment | MedStar Health

  https://www.medstarhealth.org/services/soft-tissue-sarcomas

  We offer the area’s most advanced and comprehensive care. Our team of sub-specialized physicians and advanced practice clinicians have years of experience treating people with these types of cancer. […] Our team of specialists discusses each case in bi-weekly tumor boards, where we can collectively recommend the best treatment recommendation. […] Patients with this type of sarcoma are often referred to a surgeon for evaluation. Because surgery is often the best way to remove these types of cancer, most patients will undergo a „wide resection,” during which the surgeon will remove the tumor and a layer of surrounding healthy tissue to minimize the risk of recurrence. […] When sarcoma impacts the arms or legs, we are experienced in performing limb-sparing surgery, which eliminates the need for amputation in more than 95 percent of patients.

• #3 Sarcoma: What it Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17934-sarcoma

  Chemotherapy uses drugs that kill or slow the growth of rapidly multiplying cancer cells. […] Targeted therapy attacks weaknesses in cancer cells without harming healthy cells in the process. […] Immunotherapy strengthens your immune system so that its better able to identify and fight cancer cells. […] Palliative care is specialized medical care for people with serious illnesses, including cancer. […] Your healthcare provider may also recommend you take part in a clinical trial. A clinical trial is a study that tests the safety and effectiveness of new cancer treatments. New treatments for sarcoma are always in process. A clinical trial may be an option for you, depending on your diagnosis.

• #4 Sarcoma: What it Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17934-sarcoma

  Chemotherapy uses drugs that kill or slow the growth of rapidly multiplying cancer cells. […] Targeted therapy attacks weaknesses in cancer cells without harming healthy cells in the process. […] Immunotherapy strengthens your immune system so that its better able to identify and fight cancer cells. […] Palliative care is specialized medical care for people with serious illnesses, including cancer. […] Your healthcare provider may also recommend you take part in a clinical trial. A clinical trial is a study that tests the safety and effectiveness of new cancer treatments. New treatments for sarcoma are always in process. A clinical trial may be an option for you, depending on your diagnosis.

• #4 Targeted therapy for soft tissue sarcoma | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/targeted-therapies-for-soft-tissue-sarcoma

  Imatinib may also be given if you have a GIST that cannot be operated on or has spread to other parts of the body. It may help to control it for several years. […] Sunitinib is another TKI. It may be used to treat GISTs that do not respond to imatinib, or if you get a lot of side effects with imatinib. […] Regorafenib is a newer TKI. It may sometimes be used after imatinib and sunitinib to treat an advanced GIST that cannot be removed with surgery. […] Pazopanib is another TKI. It may be used to treat some types of advanced soft tissue sarcoma. […] Crizotinib may be used to treat a rare type of sarcoma called a myofibroblastic tumour. […] Larotrectinib can be used to treat cancers that have a change in a gene called NTRK. But this is not common in sarcoma, so it is rarely used.

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