Materiały źródłowe

• #1 Leiomyosarcoma: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/22059-leiomyosarcoma

  Leiomyosarcoma symptoms vary depending on the size and location of the tumor. Some people dont experience symptoms early on, but may notice certain signs as the tumor grows, like: A firm, painless lump, Abdominal bloating, Fever, Nausea and vomiting, Pain, Tiredness, Weight loss. […] Leiomyosarcoma in your digestive system may cause: Abdominal pain, Black stools (from blood in your poop), Loss of appetite, Nausea and vomiting. […] Uterine leiomyosarcoma can cause: Abnormal uterine bleeding, Frequent urination, Vaginal discharge. […] Some people dont develop LMS symptoms until the disease reaches an advanced stage. In these cases, leiomyosarcoma is life-threatening. But when its detected and treated early, recovery is possible. […] The outlook for leiomyosarcoma varies significantly depending on the stage, size and location of the tumor. In some cases, LMS is curable, especially when detected and treated early. […] Treatment is more complicated when its discovered in the later stages. Advanced, Stage 4 leiomyosarcoma can be managed with treatment, but not cured.

• #2 Leiomyosarcoma – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/leiomyosarcoma/symptoms-causes/syc-20577215

  Leiomyosarcoma might not cause signs or symptoms at first. As the cancer grows, symptoms may include: […] Symptoms of leiomyosarcoma depend on where the cancer starts. There may be no symptoms early in the condition. […] Pain. […] Weight loss. […] Nausea and vomiting. […] A lump or swelling under the skin.

• #3 Leiomyosarcoma: Symptoms, Treatment and Prognosis

  https://www.cancercenter.com/cancer-types/soft-tissue-sarcoma/types/leiomyosarcoma

  Symptoms of leiomyosarcoma vary depending on where the cancer forms in the body and how far its progressed. Cancer patients may experience systemic changes that affect their overall health and/or cause symptoms specific to the structures directly affected by tumor growth. […] Symptoms of leiomyosarcoma may include: Pain, Fever, Fatigue, Nausea and vomiting, Unintentional weight loss, A lump under the skin, Swelling near the tumor. […] Possible symptoms of leiomyosarcoma of the digestive system: Abdominal bloating/pain, Loss of appetite, Dark stools (due to the presence of blood), Vomiting of blood. […] Possible symptoms of uterine leiomyosarcoma: Changes in bladder and bowel habits, Unusual vaginal discharge, Unusual vaginal bleeding (unrelated to a period). […] Its not uncommon for patients to have no symptoms in the early stages and only become symptomatic as the tumor begins to grow.

• #4 Leiomyosarcoma Symptoms | Power

  https://www.withpower.com/guides/leiomyosarcoma-symptoms

  Leiomyosarcoma symptoms can be subtle and may not always be tell-tale signs of cancer. Some patients are also asymptomatic. […] Common symptoms of Leiomyosarcoma include: Fever, Pain, Fatigue, Nausea, Vomiting, Sudden weight loss, Swelling near the tumor, A lump under the skin. […] In the beginning, it may appear as a painless lump in the body’s soft tissues. There may be pain or cramping in an internal organ, such as: The uterus, The digestive tract. Symptoms dont involve the bones except in serious cases. Early signs can also include Weight loss, Pain, Fever, Nausea, etc. […] Many women remain asymptomatic. The symptoms they may experience include: Abnormal bleeding from the uterus, Bleeding from the vagina. Postmenopausal bleeding can also indicate uterine Leiomyosarcoma. They may also experience the following: Unusual vaginal discharges, Pain affecting the stomach/pelvis, Change in bowel habits.

• #5 Leiomyosarcoma (Cancer in Muscles): Symptoms, Causes, Treatment

  https://www.webmd.com/cancer/leiomyosarcoma

  The signs of LMS depend on the size and location of the cancer. Some people have no symptoms. […] LMS can cause these general cancer symptoms: Bloating in your abdomen, Fatigue, Fever, Lump or swelling under your skin, Nausea and vomiting, Pain, Weight loss. […] LMS in your stomach or intestines can cause: Stomachache, Black-colored stools, Vomiting blood. […] LMS in your uterus can cause: Bleeding from your vagina that’s not from a menstrual period, Discharge from your vagina, Need to pee more often than usual. […] Because leiomyosarcoma is an aggressive and rare cancer, survival rates are best if it’s diagnosed early and contained to one part of your body. […] If you look up survival rates for leiomyosarcoma cancer, you’ll likely find information on soft tissue sarcomas. That’s not very specific. Plus, survival rates are about big groups of people and can’t predict what you can expect. Your best option is to ask your doctor about this. […] Your doctor can figure out your prognosis based on your specific details. This includes your medical history, age, and current health, as well as the size, grade, and type of your tumor, how deep it is, and where it started.

• #6 Leiomyosarcoma Cancer: Symptoms, Treatment, and More

  https://www.healthline.com/health/cancer/leiomyosarcoma-cancer

  The symptoms of LMS can vary depending on the size and location of the tumor. […] Some people may not have any symptoms in the early stages of LMS. Once symptoms do occur, they often include: fever, unintentional weight loss, pain, fatigue, bloating, nausea and vomiting, a lump you can feel and see under your skin. […] When the tumor is in the stomach, additional symptoms can include: abdominal pain, loss of appetite, bowel movements that look black or bloody. […] When the tumor is in the uterus, other symptoms you may experience can include: frequent urination, unusual vaginal discharge, unusual vaginal bleeding unrelated to menstruation. […] Medical professionals can generally treat and cure LMS when they diagnose it in the early stages. It often becomes more difficult to treat when they do not diagnose it until later stages. […] Experts can treat LMS when they diagnose it early. That’s why it’s so important to call a healthcare professional right away if you have the following symptoms, and especially if they last for more than 2 weeks: pain, fever, vomiting, lump under your skin, unintentional weight loss.

• #7 Leiomyosarcoma – Diagnosis & Disease Information for HCPs

  https://www.cancertherapyadvisor.com/ddi/leiomyosarcoma/

  Leiomyosarcoma symptoms largely depend on the location and size of the tumor. Patients with uterine leiomyosarcoma most commonly present with abnormal vaginal bleeding, pelvic pain, and an enlarging abdominal mass. If the tumor is invasive, patients may experience symptoms such as abdominal distention, dysuria, or changes in bowel habits due to local compression or invasion of adjacent organs. Symptoms of gastrointestinal leiomyosarcoma include gastrointestinal bleeding, abdominal pain, and obstructive symptoms (such as nausea, vomiting, or changes in bowel patterns) caused by tumors affecting intestinal motility. When leiomyosarcoma occurs in the retroperitoneum or soft tissues, it may present as a nontender palpable enlarging mass. In cases of pulmonary metastasis, patients may present with respiratory distress or cough. If leiomyosarcoma has spread to the liver, hepatomegaly or jaundice might be seen.

• #8 Uterine Sarcoma > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/uterine-sarcoma

  Symptoms include abnormal vaginal bleeding, pelvic and/or abdominal pain, bloating, a mass in the vagina or pelvis […] When women have uterine sarcoma, they may experience: […] Abnormal vaginal bleeding between menstrual periods […] Vaginal bleeding after menopause […] Pelvic pain […] Abdominal pain […] Bloating […] A feeling of abdominal fullness […] A palpable mass in the pelvis or vagina […] Frequent urination […] Vaginal discharge that doesnt improve with medication […] Constipation […] About two thirds (66%) of women who are diagnosed with early-stage leiomyosarcoma survive 5 years or longer. The prognosis worsens if the cancer has spread beyond the uterus, declining to a 5-year survival rate of 13 to 34%. When uterine sarcoma spreads, it often metastasizes to the lungs or the abdomen.

• #9 Uterine leiomyosarcoma symptoms, causes, and more

  https://www.medicalnewstoday.com/articles/leiomyosarcoma-uterus

  Symptoms of uterine leiomyosarcoma may vary from person to person. They can include: abnormal bleeding from the vagina and uterus, postmenopausal bleeding, pain or pressure in the pelvis or stomach, change in bladder or bowel habits, abnormal vaginal discharge, unexplained weight loss, fever, fatigue, generally feeling unwell. […] Uterine leiomyosarcoma is a rare and aggressive cancer that grows in the smooth muscle of the uterus. It can cause symptoms such as abnormal bleeding and vaginal discharge.

• #10 Uterine Leiomyosarcoma (ULMS) | LMSDR Foundation

  https://www.lmsdr.org/uterine-leiomyosarcoma-ulms-information

  Uterine leiomyosarcoma is a malignant tumor found in the smooth muscle lining the walls of the uterus. Symptoms of uLMS vary from woman to woman and can include: Heavy periods, A rapidly growing fibroid, Abnormal vaginal bleeding, Abnormal or mucousy vaginal discharge, Pelvic pain or pressure, Pain or discomfort during sexual intercourse, Abdominal pain or pressure, Abdominal bloating and distention, Change in bladder or bowel habits, Blockage of urinary flow. Uterine leiomyosarcoma is often mistaken for uterine fibroids. […] When the symptoms listed above are present, uLMS is found in nearly one in 350 women with an even higher incidence in women above the age of 40. Uterine leiomyosarcoma is an aggressive cancer that is difficult to treat. The only definitive chance of survival comes with adequate and safe surgical removal of the tumor. Uterine leiomyosarcoma cells have been known to remain dormant for even 15-20 years and then start to grow. Because of its aggressive nature, surveillance should be frequent (3-4 times a year) and long term (annually).

• #11 Leiomyosarcoma | Sarcoma UK

  https://sarcoma.org.uk/about-sarcoma/what-is-sarcoma/types-of-sarcoma/leiomyosarcoma/

  Symptoms of leiomyosarcoma can vary depending on the size and location of your tumour. You may experience all, some, or none of these symptoms before you are diagnosed with leiomyosarcoma: […] A lump or swelling in the soft tissue of the body under the skin, often on the arm, leg, or trunk, that is: […] increasing in size […] is larger than 5cm […] usually painful, but not always. […] For uterine leiomyosarcoma, symptoms may also include: […] vaginal bleeding post-menopause […] vaginal bleeding between periods […] vaginal bleeding that feels unusual to you […] pain around the pelvis or stomach. […] Leiomyosarcoma can reappear in the same area after the treatment of a previous tumour; this is called a local recurrence. […] If you experience any new symptoms or changes in your health, contact your clinical team; they may decide to bring forward the date of your follow up appointment to investigate your concerns.

• #12 Leiomyosarcoma – SFA

  https://curesarcoma.org/sarcoma-subtypes/leiomyosarcoma/

  Soft tissue LMS generally presents as a mass lesion that is often associated with nonspecific symptoms caused by the displacement of structures rather than invasion. The symptoms produced by inferior vena cava LMS depend on location. In the upper portion, it obstructs the hepatic veins and can evince Budd–Chiari syndrome with hepatomegaly, jaundice, and ascites. Tumors of the middle portion may block the renal veins. Involvement of the lower portion may cause leg edema. Imaging studies of LMS (MRI and contrast-enhanced CT) are nonspecific but helpful in delineating the relationship to adjacent structures, particularly in the retroperitoneum. […] LMSs are clinically aggressive neoplasms with frequent local recurrences and distant metastases. The most important prognostic factors are histological grade and tumor location and size. Retroperitoneal LMSs are very often fatal; they are typically large (> 10 cm), often difficult or impossible to excise with clear margins, and prone to both local recurrence and metastasis. LMSs of large vessels also tend to have a poor prognosis, although local control rates are higher. Non-retroperitoneal LMSs are generally smaller than those in the retroperitoneum, are more amenable to local control, and have a better prognosis. In some studies, intramuscular rather than subcutaneous location and larger tumor size were related to increased metastasis and poorer survival. Metastases most commonly occur in lung, liver, and soft tissue, and more rarely in bone. LMS is the most common sarcoma to produce skin metastases.

• #13 Final Diagnosis — Case 107

  https://path.upmc.edu/cases/case107/dx.html

  Cutaneous leiomyosarcomas often present as a solitary nodule smaller than 2cm, usually on the extremities, particularly on the hairbearing extensor surfaces and on the lower extremities. The overlying epidermis may exhibit a pink, purple, brown, or red discoloration; crusting; or ulceration. As many as 95% of patients report pain in association with the lesion, although some report itching, burning or bleeding. Some patients are even asymptomatic. […] Generally, cutaneous leiomyosarcomas are associated with a good prognosis. Metastases are rare, but, recurrences occur in up to 50% of cases with the most important prognostic factor being the depth of invasion. If subcutaneous extension does occur, metastasis occurs in up to 40% of cases. When metastasis is present, it most commonly is seen in the lungs. […] Pain and numbness are common symptoms. In contrast to cutaneous leiomyosarcomas, these lesions may appear well-circumscribed. The risk of metastasis is greater than in cases of cutaneous leiomyosarcomas and the risk appears to increase with depth.

• #14 Basic Information

  https://www.leiomyosarcoma.info/basic.htm

  This cancer will start in one place, and be very unpredictable. It can stay in one place, it can spread widely all over the body, it can spread locally or by metastasizing. It can be quiet for a long time, and then erupt after 20 years. It is a resistant cancer…not very responsive to chemotherapy or radiation. The best outcome occurs when it is taken out surgically with wide margins, early, while small and before it spreads. […] A stage is a period or distinct phase in the natural course of a cancer. The disease progresses from Stage I to Stage IV. It starts small [stage I] and then grows bigger [stage II or III]. Whenever metastases occur, it is stage IV, even if the primary tumor is only at stage I or II. Sometimes stage I tumors have already metastasized, although the mets may not show up for months or years. Disease progression is the march toward stage IV [also called systemic disease]. However, local recurrences can also become problematic and inoperable and therefore life-threatening. Stage I, II, and III describe the initial tumor size and depth. A cure is possible at these stages, if the surgical excision has wide clear margins. A local recurrence does not mean that a cure is not possible. Stage I to III have different chances for cure, Stage I has the highest chance of cure, and the chances for cure are less in stage III. The chance of cure varies with primary site as well as size, so this should be looked up carefully. Mitotic index is also an indicator here too. Stage IV means there is metastasis, either to nodes or distant sites. ONE metastasis makes a stage IV. It is important to stage the disease because of the prognosis. Currently there is NO CURE for stage IV. People can live for many years if their stage IV is low grade, or if it is considerate about metastasizing to operable sites. […] Leiomyosarcoma is a resistant cancer…not very responsive to chemotherapy or radiation. The best outcome occurs when it is taken out surgically with wide margins, early, while small and before it spreads.

• #15 Leiomyosarcoma – Diagnosis & Disease Information for HCPs

  https://www.cancertherapyadvisor.com/ddi/leiomyosarcoma/

  Leiomyosarcoma has a high rate of local recurrence and distant metastasis, which translates into a poor prognosis. Leiomyosarcoma is behaviorally defined as an aggressive neoplasm. Tumor-related factors that determine the prognosis of leiomyosarcoma include the following: Tumor grade: High-grade tumors have a poor prognosis; Tumor stage: Advanced leiomyosarcoma has a poor prognosis; and Tumor location: The location of the tumor affects symptoms and choice of treatment plans, and therefore the prognosis.

• #16 Leiomyosarcoma (LMS): Causes, Symptoms and Treatment

  https://www.netmeds.com/health-library/post/leiomyosarcoma-lms-causes-symptoms-and-treatment?srsltid=AfmBOooX-i3859E66TnpGFDshZdn51M5xe6r1QcIWsF7aMzYxXK-4wEz

  Generally, people may exhibit different symptoms based on how big the tumour is and where its located. While some may not notice any symptoms early on but may observe certain signs as the tumour grow like […] Pain […] Tiredness […] Abdominal bloating […] Nausea and vomiting […] Weight loss […] Fever […] A lump under your skin […] If Leiomyosarcoma is found in the digestive system, then symptoms include: […] Abdominal pain […] Poor appetite […] Nausea […] Vomiting […] Blood in the stools […] Uterine leiomyosarcoma can cause: […] Vaginal discharge […] Frequent urination […] Abnormal vaginal. […] As it is aggressive it grows very rapidly and can double in size in less than a month. Hence, prompt treatment is essential.

• #17 Leiomyosarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK551667/

  Leiomyosarcoma is an aggressive tumor of smooth muscle origin and one of the most common subtypes of sarcoma. The clinical presentation, signs, and symptoms vary depending on the site of origin. […] Symptoms are often due to compression of surrounding organs. In locations such as the retroperitoneum, tumors can grow very large before becoming symptomatic. Uterine lesions are often diagnosed through pathological examination after a hysterectomy for a suspected leiomyoma. […] Prognosis is related to the tumor’s location, size, and grade, with the tumor grade significantly impacting overall survival. With higher-grade lesions, the rate of distant metastasis increases. […] Leiomyosarcoma staging is according to the organ of origin. Uterine leiomyosarcoma staging follows the Federation of Gynecology and Obstetrics (FIGO) staging system. According to the American Joint Committee of Cancer (AJCC) staging, an extrauterine leiomyosarcoma gets staged. However, the 8th edition of AJCC has resolved a long-standing variability in STS staging. […] The three most important prognostic factors are histologic grade, tumor size, and tumor depth. Tumor size, bone, or neurovascular involvement, together with the grade of the tumor, are significantly associated with poor outcomes, specifically in leiomyosarcoma.

• #18 Leiomyosarcoma – Wikipedia

  https://en.wikipedia.org/wiki/Leiomyosarcoma

  A leiomyosarcoma (LMS) is a rare malignant (cancerous) smooth muscle tumor. […] Some of the symptoms include nausea and vomiting, palpable lumps, pain, bleeding and unintentional weight loss. […] LMSs are resistant cancers, meaning they are generally not very responsive to chemotherapy or radiation. The best outcomes occur when the tumor tissue can be removed surgically at an early stage, while it is small and has not yet spread from the original site (it remains in situ).

• #19 Leiomyosarcoma – prognosis, symptoms, causes, diagnosis and treatment in the best clinics

  https://medtour.help/disease/leiomyosarcoma/

  Unfortunately, in most cases the tumor is diagnosed in late stages and surgery is no longer possible. However, if an accurate diagnosis is made and the latest treatment methods are applied, even in the later stages there is a chance to effectively combat the disease. […] According to statistical data for leiomyosarcoma, the prognosis for five-year survival is approximately: 50-65% for the first stage; 20-50% for the second and third stages; 10-40% for the fourth stage.

• #20 Leiomyosarcoma: Success of Treatment, Stages, Support

  https://www.verywellhealth.com/leiomyosarcoma-7509839

  Generally, stage 4 tumors are called metastatic leiomyosarcomas. These cancers have spread (metastasized) to other areas of the body. The most common sites for leiomyosarcomas to spread are the lungs or liver. New tumors in these locations can cause potentially life-threatening complications. […] Because it’s aggressive and spreads quickly, leiomyosarcoma has a high risk of returning after initial treatment rounds. Even a successfully treated leiomyosarcoma can come back. This is called recurrent leiomyosarcoma. This cancer can be dormant for years, sometimes returning long after initial treatment. […] Symptoms vary depending on the location and size of the tumor. They may include pain, swelling, menstrual changes, weight loss, digestive issues, fatigue, and feeling sick.

• #21 Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy

  https://www.mdpi.com/2073-4409/13/13/1106

  The diagnosis of uLMS is established at the time of pathologic analysis of the resected tumor. This method remains the gold standard. […] Currently, the diagnosis of uLMS is established at the time of pathologic analysis of the resected tumor. This method remains the gold standard. […] The prognosis of uLMS is the worst of all soft-tissue sarcomas with the lowest survival rate. The average age of patients with this diagnosis ranges from 40 to 50 years old, and approximately 6 out of 1000 patients are diagnosed annually. Common metastatic sites for uLMS include the lungs, liver, brain, kidney, and bones. […] Unfortunately, uLMS shares many common clinical grounds with LM. In addition to originating from the smooth muscle layer of the uterus, both tumors present with clinical symptoms of heavy menses, pelvic mass, and pelvic pressure/pain.

• #22 Leiomyosarcoma – Sarcoma Oncology Center

  https://sarcomaoncology.com/types-of-sarcoma/soft-tissue-sarcomas/smooth-muscle-sarcomas/leiomyosarcoma/

  Symptoms of leiomyosarcoma depend on the tumor size and location. Patients may not experience symptoms right away. As the tumor starts to grow and compress nearby organs or connective tissues, you may experience symptoms such as: […] Leiomyosarcoma in the digestive system may cause: […] Leiomyosarcoma in the uterus can cause: […] Leiomyosarcoma is an aggressive cancer, meaning it can grow rapidly. It has the potential to metastasize or spread to other parts of the body, most commonly the lungs or liver. In cases of uterine leiomyosarcoma, the cancer can spread to nearby reproductive organs, the pelvis, abdomen, bladder, and rectum. Even after proper treatment, there is a chance for leiomyosarcoma to recur.

• #23 Leiomyosarcoma: Symptoms, Treatment and Prognosis

  https://www.cancercenter.com/cancer-types/soft-tissue-sarcoma/types/leiomyosarcoma

  The long-term prognosis for patients with leiomyosarcoma depends on a range of factors, including: The grade of the tumor, Where the cancer is located, How far its progressed, How it responds to treatment, The patients age and health at the time of diagnosis. […] When localized leiomyosarcoma is detected and treated before it has the chance to spread to other parts of the body, treatment typically increases the patients longevity. […] If the tumor is large or cancer has already spread to other parts of the body, treatment may be more challenging. Its important that patients discuss symptoms and concerns with their cancer care team as soon as possible and avoid delays in seeking care.

• #24 Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy

  https://www.mdpi.com/2073-4409/13/13/1106

  Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They have a poor prognosis with high rates of recurrence and metastasis. The five-year survival for uLMS patients is between 25 and 76%, with survival rates approaching 10–15% for patients with metastatic disease at the initial diagnosis. […] Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma. It is an aggressive tumor associated with high recurrence rates, metastasis, and poor prognosis, with a 5-year survival rate of 10 to 15% when the initial diagnosis is with metastatic disease. […] Similar clinical presentations shared by LM and uLMS include heavy and abnormal menstruation, anemia, pelvic pressure, and bulk symptoms (urinary or bowel symptoms). […] The management of each diagnosis is vastly different. LMs are benign and are treated based on the degree and severity of symptomatology, while uLMS have a high malignant potential and require immediate invasive surgical treatment, i.e., hysterectomy and adjuvant chemotherapy.

• #25 Leiomyosarcoma – Symptoms, Types, Causes & Diagnosis

  https://www.ganeshdiagnostic.com/blog/leiomyosarcoma-symptoms-types-causes-and-diagnosis

  The prognosis for leiomyosarcoma relies on a number of variables, including the tumour’s size and location, cancer’s stage, its grade, the patient’s age and general health, and the effectiveness of the treatment. […] Leiomyosarcoma is cancer that is regarded as being comparatively aggressive, and its prognosis is typically worse than that of some other sarcomas. Depending on cancer’s stage, the 5-year survival percentage for those with leiomyosarcoma varies. […] Leiomyosarcoma’s size and location of the tumour, the cancer’s stage, the presence of metastases, and the tumour’s grade are all variables that could suggest a poor prognosis.

• #26 Loss of 13q14-q21 and Gain of 5p14-pter in the Progression of Leiomyosarcoma | Modern Pathology

  https://www.nature.com/articles/3880839

  Leiomyosarcomas of soft tissues are an aggressive group of tumors with a high incidence of recurrence. […] The average survival time was shown to decrease with increase in chromosomal aberrations identified using comparative genomic hybridization. […] The survival time of patients with near-tetraploidy together with gain of 5p14-pter was reduced, and 50% died within the 1st year. […] Loss of 13q material was the most frequently observed change in the 5-year survival group, and this was significantly higher than the rate in the 5-year survival group. […] The average survival time was shorter in the near-tetraploid group compared with the tumors with diploidy or triploidy. […] Overall, in this study we have identified chromosomal changes and ploidy status associated with poor prognosis in leiomyosarcoma. Loss of 13q14-q21 and gain of 5p14-pter was found here to be associated with a shorter survival time.

• #27 Leiomyosarcoma – Symptoms, Causes and Treatment

  https://www.leiomyosarcoma.org/

  Leiomyosarcoma is considered to be rare, and treatable. It is a cancer of the soft tissue and involuntary muscle and when it is caught early it can be effectively removed. […] LMS is considered malignant cancer and is different from leiomyoma which is benign. LMS is considered treatable when caught early. […] LMS is rare, affecting only 6 in 1 million women but is highly aggressive and likely to metastasize to infect other areas of the body, including the lungs. […] Unlike other cancers that affect the uterus, LMS does not usually respond to hormonal treatments and chemotherapeutic agents or radiation treatments are sometimes inadequate. […] If the leiomyosarcoma cancer is caught in the early stages, the most effective treatment is generally surgical removal. […] More than half of all patients treated for LMS require additional treatments within 8 to 16 months after initial diagnosis. […] The five-year survival rate for patients with leiomyosarcoma is dramatically decreased if the cancer has spread and is only 4 to 16 percent.

• #28 Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy

  https://www.mdpi.com/2073-4409/13/13/1106

  The silver lining in the diagnostic dilemma between uLMS and LM is that LMs are non-cancerous tumors and mortality from this condition is extremely rare. However, LMs are the most common neoplasm in women of reproductive age, and despite their non-malignant nature, LMs can significantly impact affected patients’ quality of life, causing severe symptoms in approximately 25% of patients.

• #29 Primary pleural leiomyosarcoma with rapid progression and fatal outcome: a case report | Journal of Medical Case Reports | Full Text

  https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-6-101

  Leiomyosarcomas are neoplasms of smooth muscles that most commonly arise from the uterus, gastrointestinal tract, or soft tissue. Primary pleural leiomyosarcoma is extremely rare. […] A 58-year-old North African man was admitted with complaints of dyspnea and chest pain to our hospital. […] One month after diagnosis, the tumor grew rapidly, with pulmonary invasion, and therefore he was treated only by palliative care. He died from respiratory failure one month later. […] On radiological examination, primary pleural leiomyosarcoma presents as a mass or a pleural effusion. Metastasis is uncommon and typically occurs late in the disease process, underscoring the importance of early detection. […] The lesion in this case report is primary pleural leiomyosarcoma because imaging modalities, including CT, revealed no tumors other than the pleural tumor.

• #30 Primary pleural leiomyosarcoma with rapid progression and fatal outcome: a case report | Journal of Medical Case Reports | Full Text

  https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-6-101

  In our case report, pleural leiomyosarcoma was misdiagnosed as pleural tuberculosis because of the frequency of this infection in Morocco. The diagnosis of pleural leiomyosarcoma was made later, after deterioration of the general condition of our patient and aggressive progression of the tumor, which was unresectable.

• #31 Leiomyosarcoma of the Esophagus – Symptoms, Treatment & Support

  https://withoutaribbon.org/leiomyosarcoma-of-the-esophagus-symptoms-treatment-support/

  Symptoms of leiomyosarcoma of the esophagus may include: […] Difficulty swallowing (dysphagia), initially with solid foods and eventually with liquids. […] Chest pain or discomfort, often mistaken for heartburn or gastroesophageal reflux. […] Unintentional weight loss. […] Vomiting, which may include blood if the tumour causes bleeding. […] A feeling of fullness or pressure in the chest. […] Fatigue and weakness.

• #32 Leiomyosarcoma LMS Cancer | Symptoms and Prognosis

  https://www.wisnerbaum.com/defective-medical-device-injuries/laparoscopic-power-morcellator-lawsuit/leiomyosarcoma-lms-cancer/

  Uterine leiomyosarcoma is most common among women between the ages of 40 and 60 years of age. […] Some of the most frequent presenting symptoms include: Abnormal vaginal bleeding (amount of bleeding can vary from spotting to menorrhagia (abnormal heavy bleeding during menstruation), Pelvic or abdominal pain, Foul-smelling vaginal discharge. […] Less common symptoms can include: Weight loss, Weakness, Lethargy, Fever. […] In a pelvic exam, the uterus is often enlarged and in some cases, part of the tumor can prolapse through the cervical os (the opening of the cervix) into the vaginal canal. Diagnosis of ULMS is generally not made prior to surgery, so many patients see a physician with advanced disease. […] According to a recent study published in the International Journal of Surgical Oncology (Volume 2014), uterine leiomyosarcoma carries an extremely poor prognosis. Selected patients who had greater than a year of first recurrence, resectable disease (surgically removable) at recurrence, and early stage of the disease at initial diagnosis, a secondary cytoreductive surgery can be beneficial and may prolong survival.

• #33 Leiomyosarcoma: Causes and Symptoms

  https://www.webmd.com/cancer/what-is-leiomyosarcoma

  Many leiomyosarcomas dont cause symptoms at first. Clues include lumps or swelling as the tumor grows and pain if the tumor squeezes a nerve or muscle. If you have any of these symptoms, especially if the lump is deep in a muscle or comes back after you had a lump removed, see your doctor. […] For leiomyosarcomas in the abdomen, early signs can include pain, weight loss, nausea, or throwing up. These tumors can grow to over 4 inches across. […] In the uterus, the symptoms are often mistaken for fibroids in imaging tests. A pathologist, which is a scientist trained to identify disease, can examine uterine tissue after a hysterectomy (surgery to remove the uterus) and make the diagnosis.

• #34 Leiomyosarcoma Symptoms | Power

  https://www.withpower.com/guides/leiomyosarcoma-symptoms

  Its important to note that uterine leiomyosarcomas are malignant. This means they may spread locally and to other areas of the body. They may especially affect the liver and lungs. They can also cause life-threatening complications. […] For men, the symptoms may not be apparent at first. Some clues to look out for are: Lumps, Swelling as the tumor grows, Pain if the tumor squeezes a muscle or a nerve.

• #35 Leiomyosarcoma of the prostate | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/leiomyosarcoma-of-the-prostate?lang=us

  Leiomyosarcoma of the prostate is a rare mesenchymal smooth muscle malignancy of the prostate gland. […] Patients may complain of symptoms related to the urinary tract as urinary frequency, urgency, voiding difficulties, poor flow or urinary retention, other symptoms might include perineal or rectal pain, burning on ejaculation or weight loss. Digital rectal examination (DRE) might indicate prostatic hypertrophy or a protruding, exophytic mass. […] If left untreated leiomyosarcoma of the prostate will progress as any malignancy. In addition, it will lead to urinary retention / hydronephrosis and anemia. […] Generally, the overall prognosis of leiomyosarcoma of the prostate has been reported to be poor. Best survival rates have been reported for curative surgery with no tumor residue and no metastatic disease.

• #36 Leiomyosarcoma | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/leiomyosarcoma

  Leiomyosarcoma is a cancer of the muscle, particularly of soft tissue. It is a type of soft tissue sarcoma, and can appear in many places in the body, but in children it usually occurs in the gastrointestinal tract, which includes the stomach, small intestines, colon, appendix, rectum and anus. It can spread (metasize) to other areas of the body if its not removed, but if it is completely removed, it almost never reappear in other parts of the body. Overall, it is not a highly aggressive form of cancer and usually is not considered life threatening if it is treated early. […] Symptoms include abdominal discomfort and weight loss. […] Because soft tissue sarcomas affect tissue that is elastic and easily moved, a tumor may exist for a long time before being discovered, growing large and pushing aside surrounding tissue. Symptoms vary greatly with the size, location and spread of the tumor, but may include: Painless swelling or mass anywhere on the body, Pain or soreness caused by compressed nerves or muscles, Limping or other difficulty using the legs, feet, arms, or hands.

• #37 Leiomyosarcoma | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/leiomyosarcoma

  If a child has leiomyosarcoma, usually the symptoms do not appear until adolescence, since it usually occurs in adults. […] Surgical removal is usually the first and most important treatment option. If the tumors are, completely removed, it won’t re-appear in another part of the body. […] Leiomyosarcoma is extremely rare, and there are no official numbers on how well children manage the disease in the long term. However, doctors have studied soft tissue sarcomas (which is the category of cancer that and find that leiomyosarcoma falls under) and find that if a soft tissue sarcoma is completely resected, or removed, the survival rate is 80 percent or greater.

• #38 Leiomyosarcoma: Success of Treatment, Stages, Support

  https://www.verywellhealth.com/leiomyosarcoma-7509839

  Depending on the tumor’s location, you may feel it as a lump under the skin. There may be some pain or swelling in the area, too. […] Other leiomyosarcoma symptoms depend on the size and location of the cancer and if it has spread to other body parts. As these tumors get bigger, they can interfere with how organs function, causing symptoms related to that. For example: GIST leiomyosarcoma in the digestive tract can cause bleeding and other digestive issues. Uterine leiomyosarcoma can cause menstrual changes, for example such as bleeding or discharge. […] As a leiomyosarcoma gets large and spreads to other organs, it can cause symptoms of metastatic cancer (cancer that has spread to other areas of the body). These include: Pain, Losing weight for no reason, Digestive issues like nausea and vomiting, Unexplained fatigue, Fever, A general feeling of ill health.

• #39 Outcomes of patients with pelvic leiomyosarcoma treated by surgery and relevant auxiliary diagnosis

  https://www.wjgnet.com/2307-8960/full/v8/i10/1887.htm

  Serum tumour biomarkers cannot be used for pelvic leiomyosarcoma diagnosis. FIGO stage is critical to predict the outcome of uterine leiomyosarcoma. Ultrasonography is more reliable for postoperative follow-up than preoperative diagnosis. […] Owing to a lack of long-term leiomyosarcoma-focused studies, the clinical features of pelvic leiomyosarcoma among women remain unclear. Our study showed that serum tumour biomarkers cannot be used for pelvic leiomyosarcoma diagnosis and ultrasonography is more reliable for postoperative follow-up than preoperative diagnosis. […] The treatment methods and prognostic factors related to leiomyosarcoma require extensive research because of the diseases high malignant potential. Previous studies have confirmed that the standard surgical resection of uterine leiomyosarcoma is associated with improved prognoses.

• #40 Leiomyosarcoma – Pre-Diagnosis, Signs & Symptoms – Cancer Chat | Cancer Research UK

  https://cancerchat.cancerresearchuk.org/f/pre-diagnosis-signs-symptoms/121302/leiomyosarcoma

  I have a lump in my calf and its very painful a couple of years ago I had a large liomysarcoma on my left kydney I had surgery to take it away could this come back in my calf ? […] I am not sure myself whether a leiomyosarcoma can come back on your calf or if this lump is totally unrelated but as with any new lump you notice anywhere in your body, it is important to get it checked. […] You can mention to the doctor’s your history and say that you had a large leiomyosarcoma removed a couple of years ago and that you are worried that the two might be connected.

• #41

  http://waocp.com/journal/index.php/apjcc/article/view/1058

  Leiomyosarcoma (LMS) is a rare malignancy which develops from the smooth muscles. […] The prognosis is usually poor as rate of local, regional and distant metastasis is high. […] Leiomyosarcomas have an indolent growth but may grow up to 10 cm with nonspecific symptoms. […] The nature of spread is the same with other sarcomas, metastasizing more commonly to the lungs and rarely through the lymphatic system. […] Local recurrence, regional lymph nodes and distant metastasis to the lungs occur is about 34%, 15% and 35% of cases respectively, hence long term follow-up is necessary. […] Upon reevaluation, Chest CT scan showed multiple subcentimeter non-calcified pulmonary, subpleural, and fissural nodules in both lungs, largest was seen in the left upper lobe, measuring 0.7 cm. […] Repeat Chest CT scan showed further increase in size and number of the pulmonary nodules, the largest in the left upper lobe this time measures 1.7 x 1.5 cm.

• #42

  http://waocp.com/journal/index.php/apjcc/article/view/1058

  However on September 2018, 6 months after increasing Pazopanib dose, patient again progressed on the lung. […] The non-calcified nodule in the lateral basal segment of the left lower lobe shows interval increase in size measuring 1.3 x 1.8 cm and exhibits cavitation. […] There are limited options for Progressive Leiomyosarcoma. […] Patient eventually succumbed to death. […] Leiomyosarcoma is a rare disease and data on treatment beyond progression is scarce. […] Despite subsequent treatments, patient continued to progress.

• #43 Trabectedin Significantly Slows Progression in Uterine Leiomyosarcoma

  https://www.onclive.com/view/trabectedin-significantly-slows-progression-in-uterine-leiomyosarcoma

  Treatment with trabectedin significantly improved progression-free survival compared with dacarbazine in women with advanced uterine leiomyosarcoma, according to a subgroup analysis of the phase III SAR-3007 trial. […] Patients with uterine leiomyosarcoma who received trabectedin had a median PFS of 4.0 months versus 1.5 months with dacarbazine, almost identical to previously reported results in the overall study population of patients with leiomyosarcoma and liposarcoma. […] The subgroup analysis confirmed the significant PFS benefit with trabectedin demonstrated in the overall trial. The 2.5-month PFS benefit with trabectedin translated into a 43% reduction in the risk of progression (HR, 0.57; 95% CI, 0.41-0.81; P = .0012).

• #44 Longer survival in patients with metastatic uterine leiomyosarcoma treated with trabectedin: A case report

  https://www.spandidos-publications.com/10.3892/mco.2019.1797

  Trabectedin (ET743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with a chemical structure characterized by three fused tetrahydroisoquinoline rings. In the present case report, two patients with advanced and metastatic uterine leiomyosarcomas (ULMS) with significant progression-free survival (PFS) and overall survival (OS) administered Trabectedin as second and third line treatment are reported. The first case received third line Trabectedin with a PFS of 24 months and an OS of 35 months. The second case received second line Trabectedin with a PFS of 24 months and an OS of 30 months. In addition, a good safety record was obtained in the long-term administration of Trabectedin (more so in case 1 than case 2), with a good quality of life. […] Uterine leiomyosarcomas (ULMS) are rare malignant tumors. They represent approximately 1% of overall uterine tumors, and have a very poor prognosis. The 5-year overall survival (OS) is between 30 and 42%. Less than 20% of metastatic ULMS showed complete or partial responses with doxorubicin, gemcitabine, or dacarbazine treatment. The median progression-free survival (PFS) was 5 months and OS 12 months.

• #45 Longer survival in patients with metastatic uterine leiomyosarcoma treated with trabectedin: A case report

  https://www.spandidos-publications.com/10.3892/mco.2019.1797

  We report two cases demonstrating a durable partial response of Trabectedin in advanced line treatment of patients with advanced and metastatic uterine leiomyosarcoma. […] It is difficult, especially with only two cases, to determine whether PFS of those patients is linked to natural progression of the disease or effect of the chemotherapy. However, Trabectedin was the most well-tolerated drug over a long period of administration for patient case report 1. After 9 months of therapeutic break, disease progression was reduced and the reintroduction of Trabectedin led to approximately 2 years of non-progression. Despite the relatively fast control of the disease obtained with Trabectedin, it has been suggested that it should be administered at least during the first year of therapy, since retarded positive effect has been shown for some patients. The two cases of the current study clearly indicate the potential of this drug for progressing tumor under first line of chemotherapy. Indeed, findings have shown that despite the fact that Trabectedin has failed to prove its effectiveness in tumor reduction, it seems to have a great stabilization effect, with PFS well above all other types of chemotherapy used for ULMS. […] In case report 2, even after heavy dose reduction of Trabectedin, this drug was positively maintained for almost one year and allowed us to obtain a subtotal response.

• #46 Leiomyosarcoma – NCI

  https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-soft-tissue-tumors/leiomyosarcoma

  Symptoms depend on where the tumor is and how big it is. Some people with LMS do not have symptoms when the cancer first starts. Later, when the tumor gets larger, symptoms can include: […] When LMS is identified early and is removed by surgery, prognosis is good and full recovery is likely. When LMS is already large or has spread to other parts of the body, treatment is more difficult and the prognosis is not as good.

Zobacz więcej